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Aliases for EIF3J Gene

Aliases for EIF3J Gene

  • Eukaryotic Translation Initiation Factor 3 Subunit J 2 3 5
  • EIF3S1 3 4
  • Eukaryotic Translation Initiation Factor 3, Subunit 1 (Alpha, 35kD) 3
  • Eukaryotic Translation Initiation Factor 3, Subunit 1 Alpha, 35kDa 2
  • Eukaryotic Translation Initiation Factor 3, Subunit J 2
  • Eukaryotic Translation Initiation Factor 3 Subunit 1 4
  • EIF-3-Alpha 4
  • EIF3-Alpha 3
  • EIF3-P35 3
  • EIF3 P35 4
  • EIF3j 4

External Ids for EIF3J Gene

Previous HGNC Symbols for EIF3J Gene

  • EIF3S1

Previous GeneCards Identifiers for EIF3J Gene

  • GC15P042617
  • GC15P044829
  • GC15P021653

Summaries for EIF3J Gene

Entrez Gene Summary for EIF3J Gene

  • This gene encodes a core subunit of the eukaryotic initiation factor 3 complex, which participates in the initiation of translation by aiding in the recruitment of protein and mRNA components to the 40S ribosome. There are pseudogenes for this gene on chromosomes 1, 3, and 9. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Sep 2013]

GeneCards Summary for EIF3J Gene

EIF3J (Eukaryotic Translation Initiation Factor 3 Subunit J) is a Protein Coding gene. Among its related pathways are Viral mRNA Translation and Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S. GO annotations related to this gene include translation initiation factor activity.

UniProtKB/Swiss-Prot for EIF3J Gene

  • Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis (PubMed:25849773, PubMed:27462815). The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, including cell cycling, differentiation and apoptosis, and uses different modes of RNA stem-loop binding to exert either translational activation or repression (PubMed:25849773).

Gene Wiki entry for EIF3J Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for EIF3J Gene

Genomics for EIF3J Gene

Regulatory Elements for EIF3J Gene

Enhancers for EIF3J Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH15G044491 1.1 ENCODE 11.6 -44.3 -44294 2.2 PKNOX1 CREB3L1 ARNT ARID4B SIN3A DMAP1 FEZF1 ZNF2 YY1 ZNF766 EIF3J EIF3J-AS1 STRCP1 ENSG00000259563 HNRNPMP1
GH15G044535 1.1 ENCODE 0.7 +0.1 129 3.5 HDGF FOXA2 CREB3L1 MLX ARNT AGO1 SIN3A ARID4B DMAP1 ZNF2 ENSG00000259659 EIF3J
GH15G044540 1 Ensembl ENCODE 0.7 +4.7 4669 2.3 CTCF SOX13 CEBPG THRB YY1 ZNF121 FOXK2 GATAD2A FOXA3 HMG20A ENSG00000259659 EIF3J
GH15G044546 0.7 ENCODE 0.4 +9.2 9156 1.8 CTCF PKNOX1 ZNF362 ASH2L JUNB REST DPF2 ARID3A IKZF1 ETV6 ENSG00000259659 TRIM69 EIF3J
GH15G044545 0.5 FANTOM5 0.4 +8.1 8056 0.2 NR2F1 CEBPA ZNF600 PATL2 CTDSPL2 EIF3J ENSG00000259659
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around EIF3J on UCSC Golden Path with GeneCards custom track

Promoters for EIF3J Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000075940 43 2601 HDGF MLX CREB3L1 ARNT AGO1 ARID4B SIN3A DMAP1 ZNF2 YY1

Genomic Location for EIF3J Gene

Chromosome:
15
Start:
44,537,057 bp from pter
End:
44,563,029 bp from pter
Size:
25,973 bases
Orientation:
Plus strand

Genomic View for EIF3J Gene

Genes around EIF3J on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
EIF3J Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for EIF3J Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for EIF3J Gene

Proteins for EIF3J Gene

  • Protein details for EIF3J Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O75822-EIF3J_HUMAN
    Recommended name:
    Eukaryotic translation initiation factor 3 subunit J
    Protein Accession:
    O75822
    Secondary Accessions:
    • B4DUI3
    • F5H425
    • Q9BUD2
    • Q9H8Q2
    • Q9UI65

    Protein attributes for EIF3J Gene

    Size:
    258 amino acids
    Molecular mass:
    29062 Da
    Quaternary structure:
    • Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is composed of 13 subunits: EIF3A, EIF3B, EIF3C, EIF3D, EIF3E, EIF3F, EIF3G, EIF3H, EIF3I, EIF3J, EIF3K, EIF3L and EIF3M. The eIF-3 complex appears to include 3 stable modules: module A is composed of EIF3A, EIF3B, EIF3G and EIF3I; module B is composed of EIF3F, EIF3H, and EIF3M; and module C is composed of EIF3C, EIF3D, EIF3E, EIF3K and EIF3L. EIF3C of module C binds EIF3B of module A and EIF3H of module B, thereby linking the three modules. EIF3J is a labile subunit that binds to the eIF-3 complex via EIF3B. The eIF-3 complex interacts with RPS6KB1 under conditions of nutrient depletion. Mitogenic stimulation leads to binding and activation of a complex composed of MTOR and RPTOR, leading to phosphorylation and release of RPS6KB1 and binding of EIF4B to eIF-3.

    Three dimensional structures from OCA and Proteopedia for EIF3J Gene

    Alternative splice isoforms for EIF3J Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for EIF3J Gene

Post-translational modifications for EIF3J Gene

  • Phosphorylated. Phosphorylation is enhanced upon serum stimulation.
  • Ubiquitination at Lys161
  • Modification sites at PhosphoSitePlus

Other Protein References for EIF3J Gene

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for EIF3J (eIF3-alpha)
  • Santa Cruz Biotechnology (SCBT) Antibodies for EIF3J

No data available for DME Specific Peptides for EIF3J Gene

Domains & Families for EIF3J Gene

Gene Families for EIF3J Gene

Protein Domains for EIF3J Gene

Suggested Antigen Peptide Sequences for EIF3J Gene

Graphical View of Domain Structure for InterPro Entry

O75822

UniProtKB/Swiss-Prot:

EIF3J_HUMAN :
  • Belongs to the eIF-3 subunit J family.
Family:
  • Belongs to the eIF-3 subunit J family.
genes like me logo Genes that share domains with EIF3J: view

Function for EIF3J Gene

Molecular function for EIF3J Gene

UniProtKB/Swiss-Prot Function:
Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis (PubMed:25849773, PubMed:27462815). The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, including cell cycling, differentiation and apoptosis, and uses different modes of RNA stem-loop binding to exert either translational activation or repression (PubMed:25849773).

Gene Ontology (GO) - Molecular Function for EIF3J Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003743 contributes_to translation initiation factor activity IEA,IC 17322308
GO:0005515 protein binding IPI 14688252
genes like me logo Genes that share ontologies with EIF3J: view
genes like me logo Genes that share phenotypes with EIF3J: view

Animal Model Products

CRISPR Products

miRNA for EIF3J Gene

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for EIF3J Gene

Localization for EIF3J Gene

Subcellular locations from UniProtKB/Swiss-Prot for EIF3J Gene

Cytoplasm.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for EIF3J gene
Compartment Confidence
cytosol 5
nucleus 2

Gene Ontology (GO) - Cellular Components for EIF3J Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
GO:0005829 cytosol TAS --
GO:0005852 eukaryotic translation initiation factor 3 complex IDA,IEA 17322308
GO:0016282 eukaryotic 43S preinitiation complex IEA --
GO:0033290 eukaryotic 48S preinitiation complex IEA --
genes like me logo Genes that share ontologies with EIF3J: view

Pathways & Interactions for EIF3J Gene

genes like me logo Genes that share pathways with EIF3J: view

Gene Ontology (GO) - Biological Process for EIF3J Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006412 translation IEA --
GO:0006413 translational initiation TAS,IEA --
GO:0006446 regulation of translational initiation IEA --
genes like me logo Genes that share ontologies with EIF3J: view

No data available for SIGNOR curated interactions for EIF3J Gene

Transcripts for EIF3J Gene

Unigene Clusters for EIF3J Gene

Eukaryotic translation initiation factor 3, subunit J:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for EIF3J Gene

No ASD Table

Relevant External Links for EIF3J Gene

GeneLoc Exon Structure for
EIF3J
ECgene alternative splicing isoforms for
EIF3J

Expression for EIF3J Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for EIF3J Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for EIF3J Gene

This gene is overexpressed in Muscle - Skeletal (x4.5).

Protein differential expression in normal tissues from HIPED for EIF3J Gene

This gene is overexpressed in Peripheral blood mononuclear cells (8.3) and Serum (7.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for EIF3J Gene



Protein tissue co-expression partners for EIF3J Gene

NURSA nuclear receptor signaling pathways regulating expression of EIF3J Gene:

EIF3J

SOURCE GeneReport for Unigene cluster for EIF3J Gene:

Hs.404056

Evidence on tissue expression from TISSUES for EIF3J Gene

  • Nervous system(4.8)
  • Liver(4.4)
  • Muscle(4.3)
genes like me logo Genes that share expression patterns with EIF3J: view

Primer Products

No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for EIF3J Gene

Orthologs for EIF3J Gene

This gene was present in the common ancestor of animals.

Orthologs for EIF3J Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia EIF3J 34
  • 99.73 (n)
oppossum
(Monodelphis domestica)
Mammalia -- 35
  • 97 (a)
OneToMany
-- 35
  • 94 (a)
OneToMany
dog
(Canis familiaris)
Mammalia EIF3J 34 35
  • 95.85 (n)
mouse
(Mus musculus)
Mammalia Eif3j2 16 35
  • 95 (a)
Eif3j1 34 35
  • 93.87 (n)
rat
(Rattus norvegicus)
Mammalia Eif3j 34
  • 94.27 (n)
cow
(Bos Taurus)
Mammalia EIF3J 34 35
  • 93.59 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia EIF3J 35
  • 84 (a)
OneToOne
chicken
(Gallus gallus)
Aves EIF3J 34 35
  • 78.31 (n)
lizard
(Anolis carolinensis)
Reptilia EIF3J 35
  • 79 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia eif3j 34
  • 68.94 (n)
African clawed frog
(Xenopus laevis)
Amphibia Xl.21408 34
zebrafish
(Danio rerio)
Actinopterygii eif3ja 34 35
  • 70.61 (n)
eif3jb 35
  • 60 (a)
OneToMany
EIF3J (3 of 3) 35
  • 56 (a)
OneToMany
-- 34
fruit fly
(Drosophila melanogaster)
Insecta Adam 34 35
  • 50.16 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta EIF3J_ANOGA 34
  • 48.06 (n)
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 38 (a)
OneToOne
Species where no ortholog for EIF3J was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for EIF3J Gene

ENSEMBL:
Gene Tree for EIF3J (if available)
TreeFam:
Gene Tree for EIF3J (if available)

Paralogs for EIF3J Gene

genes like me logo Genes that share paralogs with EIF3J: view

No data available for Paralogs for EIF3J Gene

Variants for EIF3J Gene

Sequence variations from dbSNP and Humsavar for EIF3J Gene

SNP ID Clin Chr 15 pos Sequence Context AA Info Type
rs200079802 Pathogenic 44,563,302(+) TATAT(C/G)TAGAT downstream-variant-500B, splice-acceptor-variant
rs312262792 Pathogenic 44,563,296(-) ATATA(-/AAAC)AACAA downstream-variant-500B, reference, frameshift-variant
rs116069609 Uncertain significance 44,562,878(+) AGCTT(C/T)TGATC downstream-variant-500B, utr-variant-3-prime
rs527843501 Uncertain significance 44,562,880(+) CTTTT(C/G)ATCTT downstream-variant-500B, utr-variant-3-prime
rs774245742 Uncertain significance 44,562,822(+) GTATT(A/C)TTTAA downstream-variant-500B, utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for EIF3J Gene

Variant ID Type Subtype PubMed ID
nsv977706 CNV duplication 23825009

Variation tolerance for EIF3J Gene

Residual Variation Intolerance Score: 55.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.36; 76.90% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for EIF3J Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
EIF3J

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for EIF3J Gene

Disorders for EIF3J Gene

Relevant External Links for EIF3J

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
EIF3J

No disorders were found for EIF3J Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for EIF3J Gene

Publications for EIF3J Gene

  1. Characterization of cDNAs encoding the p44 and p35 subunits of human translation initiation factor eIF3. (PMID: 9822659) Block K.L. … Hershey J.W.B. (J. Biol. Chem. 1998) 2 3 4 22 64
  2. Mass spectrometry reveals modularity and a complete subunit interaction map of the eukaryotic translation factor eIF3. (PMID: 18599441) Zhou M. … Robinson C.V. (Proc. Natl. Acad. Sci. U.S.A. 2008) 3 4 64
  3. Structural characterization of the human eukaryotic initiation factor 3 protein complex by mass spectrometry. (PMID: 17322308) Damoc E. … Leary J.A. (Mol. Cell. Proteomics 2007) 3 4 64
  4. Structure of eIF3b RNA recognition motif and its interaction with eIF3j: structural insights into the recruitment of eIF3b to the 40 S ribosomal subunit. (PMID: 17190833) ElAntak L. … Lukavsky P.J. (J. Biol. Chem. 2007) 3 4 64
  5. eIF3j is located in the decoding center of the human 40S ribosomal subunit. (PMID: 17588516) Fraser C.S. … Doudna J.A. (Mol. Cell 2007) 3 4 64

Products for EIF3J Gene

Sources for EIF3J Gene

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