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EIF3J Gene

protein-coding   GIFtS: 54
GCID: GC15P044829

Eukaryotic Translation Initiation Factor 3, Subunit J

(Previous names: eukaryotic translation initiation factor 3, subunit 1 alpha,...)
(Previous symbol: EIF3S1)
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Eukaryotic Translation Initiation Factor 3, Subunit J1 2     Eukaryotic Translation Initiation Factor 3, Subunit 1 (Alpha, 35kD)2
EIF3S11 2 3 5     eIF-3-alpha3
Eukaryotic Translation Initiation Factor 3, Subunit 1 Alpha, 35kDa1     eIF3j3
eIF3-alpha2     EIF3 P353
eIF3-p352     Eukaryotic Translation Initiation Factor 3 Subunit 13
Eukaryotic Translation Initiation Factor 3 Subunit J2     

External Ids:    HGNC: 32701   Entrez Gene: 86692   Ensembl: ENSG000001041317   OMIM: 6039105   UniProtKB: O758223   

Export aliases for EIF3J gene to outside databases

Previous GC identifers: GC15P042617 GC15P021653


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for EIF3J Gene:
This gene encodes a core subunit of the eukaryotic initiation factor 3 complex, which participates in the
initiation of translation by aiding in the recruitment of protein and mRNA components to the 40S ribosome. There
are pseudogenes for this gene on chromosomes 1, 3, and 9. Alternative splicing results in multiple transcript
variants encoding different isoforms. (provided by RefSeq, Sep 2013)

GeneCards Summary for EIF3J Gene:
EIF3J (eukaryotic translation initiation factor 3, subunit J) is a protein-coding gene. GO annotations related to this gene include translation initiation factor activity.

UniProtKB/Swiss-Prot: EIF3J_HUMAN, O75822
Function: Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for
several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and
facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S preinitiation
complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG
recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal
complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation.
This subunit binds directly within the mRNA entry channel of the 40S ribosome to the aminoacyl (A) site. It may
regulate the interaction between the 43S PIC and mRNA

Gene Wiki entry for EIF3J Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000015.9  NC_018926.2  NT_010194.18  
Regulatory elements:
   Regulatory transcription factor binding sites in the EIF3J gene promoter:
         HOXA9B   HOXA9   Sox5   POU3F2 (N-Oct-5b)   CREB   MEF-2A   deltaCREB   Meis-1a   aMEF-2   Meis-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidEIF3J promoter sequence
   Search Chromatin IP Primers for EIF3J

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat EIF3J


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 15q21.1   Ensembl cytogenetic band:  15q21.1   HGNC cytogenetic band: 15q21.1

EIF3J Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
EIF3J gene location

GeneLoc information about chromosome 15         GeneLoc Exon Structure

GeneLoc location for GC15P044829:  view genomic region     (about GC identifiers)

Start:
44,829,255 bp from pter      End:
44,855,227 bp from pter
Size:
25,973 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: EIF3J_HUMAN, O75822 (See protein sequence)
Recommended Name: Eukaryotic translation initiation factor 3 subunit J  
Size: 258 amino acids; 29062 Da
Subunit: Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is composed of 13
subunits: EIF3A, EIF3B, EIF3C, EIF3D, EIF3E, EIF3F, EIF3G, EIF3H, EIF3I, EIF3J, EIF3K, EIF3L and EIF3M. The eIF-3
complex appears to include 3 stable modules: module A is composed of EIF3A, EIF3B, EIF3G and EIF3I; module B is
composed of EIF3F, EIF3H, and EIF3M; and module C is composed of EIF3C, EIF3D, EIF3E, EIF3K and EIF3L. EIF3C of
module C binds EIF3B of module A and EIF3H of module B, thereby linking the three modules. EIF3J is a labile
subunit that binds to the eIF-3 complex via EIF3B. The eIF-3 complex interacts with RPS6KB1 under conditions of
nutrient depletion. Mitogenic stimulation leads to binding and activation of a complex composed of MTOR and
RPTOR, leading to phosphorylation and release of RPS6KB1 and binding of EIF4B to eIF-3
Mass spectrometry: Mass=29293.2; Method=Unknown; Range=1-258; Source=PubMed:17322308;
Mass spectrometry: Mass=28974.2; Mass_error=0.3; Method=MALDI; Range=1-258; Source=PubMed:18599441;
2 PDB 3D structures from and Proteopedia for EIF3J:
2KRB (3D)        3BPJ (3D)    
Secondary accessions: Q9BUD2 Q9H8Q2 Q9UI65

Explore the universe of human proteins at neXtProt for EIF3J: NX_O75822

Explore proteomics data for EIF3J at MOPED

Post-translational modifications: 

  • Phosphorylated. Phosphorylation is enhanced upon serum stimulation1
  • Ubiquitination2 at Lys161
  • Modification sites at PhosphoSitePlus

  • See EIF3J Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (3 alternative transcripts): 
    NP_001271264.1  NP_001271265.1  NP_003749.2  

    ENSEMBL proteins: 
     ENSP00000261868   ENSP00000414548   ENSP00000440221   ENSP00000443563   ENSP00000453282  
    Reactome Protein details: O75822

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    2 InterPro protein domains:
     IPR013906 eIF3j
     IPR023194 eIF3-like_dom

    Graphical View of Domain Structure for InterPro Entry O75822

    ProtoNet protein and cluster: O75822

    1 Blocks protein domain: IPB013906 Translation initiation factor eIF3 subunit

    UniProtKB/Swiss-Prot: EIF3J_HUMAN, O75822
    Similarity: Belongs to the eIF-3 subunit J family


    Find genes that share domains with EIF3J           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: EIF3J_HUMAN, O75822
    Function: Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for
    several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and
    facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S preinitiation
    complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG
    recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal
    complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation.
    This subunit binds directly within the mRNA entry channel of the 40S ribosome to the aminoacyl (A) site. It may
    regulate the interaction between the 43S PIC and mRNA

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003743contributes to translation initiation factor activity IC17322308
    GO:0005515protein binding IPI14688252
         
    Find genes that share ontologies with EIF3J           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for EIF3J:
     Increased G1 DNA content 

    Animal Models:
       genOway: Develop your customized and physiologically relevant rodent model for EIF3J

    miRNA
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    miRTarBase miRNAs that target EIF3J:
    hsa-let-7e-5p (MIRT003932), hsa-mir-98-5p (MIRT027570), hsa-mir-155-5p (MIRT020659), hsa-mir-320a (MIRT044772)

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    hsa-miR-582-3p hsa-miR-4265 hsa-miR-218-2* hsa-miR-1271 hsa-miR-340 hsa-miR-221 hsa-miR-20b* hsa-miR-508-3p
    SwitchGear 3'UTR luciferase reporter plasmidEIF3J 3' UTR sequence
    Inhib. RNA
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    EIF3J_HUMAN, O75822: Cytoplasm (By similarity)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol4
    nucleus2

    Gene Ontology (GO): 5 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm ----
    GO:0005829cytosol TAS--
    GO:0005852eukaryotic translation initiation factor 3 complex IDA17322308
    GO:0016282eukaryotic 43S preinitiation complex IEA--
    GO:0033290eukaryotic 48S preinitiation complex IEA--

    Find genes that share ontologies with EIF3J           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for EIF3J About   (see all 7)  
    See pathways by source

    SuperPathContained pathways About
    1Influenza Viral RNA Transcription and Replication
    L13a-mediated translational silencing of Ceruloplasmin expression0.94
    Cap-dependent Translation Initiation0.89
    Formation of a pool of free 40S subunits0.94
    Eukaryotic Translation Initiation0.89
    GTP hydrolysis and joining of the 60S ribosomal subunit0.93
    Translation0.82
    2Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S
    Translation initiation complex formation0.91
    Formation of the ternary complex, and subsequently, the 43S complex0.91
    Ribosomal scanning and start codon recognition0.91
    Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S0.90
    3Gene Expression
    Gene Expression0.40
    4Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein
    Metabolism of proteins0.30
    5Translational Control
    Translational Control


    Find genes that share SuperPaths with EIF3J           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    2 Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for EIF3J
        eIF2 Pathway
    mTOR Pathway

    1 Cell Signaling Technology (CST) Pathway for EIF3J
        Translational Control

    1 BioSystems Pathway for EIF3J
        Translation Factors

    Selected Reactome Pathways for EIF3J (see all 6)
        Formation of the ternary complex, and subsequently, the 43S complex
    L13a-mediated translational silencing of Ceruloplasmin expression
    GTP hydrolysis and joining of the 60S ribosomal subunit
    Ribosomal scanning and start codon recognition
    Formation of a pool of free 40S subunits


    1 Kegg Pathway  (Kegg details for EIF3J):
        RNA transport

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for EIF3J
    Interactions:

        GeneGlobe Interaction Network for EIF3J

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for EIF3J (O758221, 2, 3 ENSP000002618684) via UniProtKB, MINT, STRING, and/or I2D (see all 167)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    EIF4G1Q046371, 2, 3, ENSP000003168794EBI-366647,EBI-73711 MINT-2984145 MINT-2984124 I2D: score=1 STRING: ENSP00000316879
    EIF3BP558841, 3, ENSP000003541254EBI-366647,EBI-366696 I2D: score=4 STRING: ENSP00000354125
    GOLM1Q8NBJ42, 3MINT-64959 I2D: score=5 
    TPD52L1Q168902, 3MINT-63144 I2D: score=5 
    EIF4G2P783442, 3, ENSP000003402814MINT-2984013 I2D: score=1 STRING: ENSP00000340281
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001731formation of translation preinitiation complex IEA--
    GO:0006412translation TAS--
    GO:0006413translational initiation TAS--
    GO:0006446regulation of translational initiation IEA--
    GO:0010467gene expression TAS--

    Find genes that share ontologies with EIF3J           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Tocris compounds for EIF3J



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for EIF3J gene (3 alternative transcripts): 
    NM_001284335.1  NM_001284336.1  NM_003758.3  

    Unigene Cluster for EIF3J:

    Eukaryotic translation initiation factor 3, subunit J
    Hs.404056  [show with all ESTs]
    Unigene Representative Sequence: NM_003758
    7 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000261868(uc001ztv.3 uc010ueg.2) ENST00000424492 ENST00000535391
    ENST00000558227 ENST00000558053 ENST00000536248 ENST00000558353
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    hsa-miR-582-3p hsa-miR-4265 hsa-miR-218-2* hsa-miR-1271 hsa-miR-340 hsa-miR-221 hsa-miR-20b* hsa-miR-508-3p
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    Additional mRNA sequence: 

    AF090923.1 AK002006.1 AK023388.1 AK300659.1 BC002719.2 U97670.1 

    21 DOTS entries:

    DT.100059258  DT.100673143  DT.95283891  DT.100668177  DT.86859349  DT.97793497  DT.99982148  DT.100047222 
    DT.120882278  DT.121608633  DT.40107487  DT.87007466  DT.95276013  DT.95336757  DT.100722794  DT.100839875 
    DT.121066324  DT.121066345  DT.95253739  DT.99976809  DT.99994859 

    Selected AceView cDNA sequences (see all 330):

    CK905834 BQ188958 BX461055 BF062997 BU182108 CR620283 AL120728 BM772587 
    CR607662 CA312787 BC002719 BU903025 BE887692 BU783904 CA444378 BM700067 
    BQ431102 AK002006 BM479530 BP374131 BF448225 AI202412 BP342562 AI142648 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    EIF3J expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CTCAGCAAAC
    EIF3J Expression
    About this image

    EIF3J Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    EIF3J Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.404056
        Custom PCR Arrays for EIF3J
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    In Situ
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for EIF3J

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for EIF3J gene from Selected species (see all 16)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Eif3j11 , 5 eukaryotic translation initiation factor 3, subunit more1, 5 93.87(n)1
    96.8(a)1
      2 (60.49 cM)5
    786551  NM_144545.41  NP_653128.21 
     1220285465 
    chicken
    (Gallus gallus)
    Aves EIF3J1 eukaryotic translation initiation factor 3, subunit more 78.31(n)
    80.72(a)
      415573  NM_001012771.2  NP_001012789.1 
    lizard
    (Anolis carolinensis)
    Reptilia EIF3J6
    eukaryotic translation initiation factor 3, subuni...
    79(a)
    1 ↔ 1
    GL343642.1(331417-337602)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.214082 Xenopus laevis transcribed sequence with weak similarity more 78.8(n)    48016522 
    zebrafish
    (Danio rerio)
    Actinopterygii BC055247.12   -- 78.47(n)   394189  BC055247.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Adam1 Adam 50.16(n)
    42.86(a)
      36037  NM_136697.2  NP_610541.1 


    ENSEMBL Gene Tree for EIF3J (if available)
    TreeFam Gene Tree for EIF3J (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for EIF3J gene

    Find genes that share paralogs with EIF3J           About GenesLikeMe


    Selected Pseudogenes.org Pseudogenes for EIF3J (see all 6)
    PGOHUM00000259503 PGOHUM00000240060 PGOHUM00000238229 PGOHUM00000260526 PGOHUM00000236677


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for EIF3J (see all 459)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 15 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1487727621,2
    C--24893933(+) CAATT-/GTGA  
            
    GTAAG
    1 -- us2k10--------
    rs603996721,2
    C,F--24893980(+) TCCTGA/CCTTCT 1 -- us2k13Minor allele frequency- C:0.13WA NA EA 358
    rs1908492661,2
    --44831274(+) GGCTGC/GAGTGC 1 -- int10--------
    rs1472464951,2
    --44831294(+) ATCTTC/GGCTCA 1 -- int10--------
    rs1396911091,2
    --44831381(+) CACCAC/TGCCTG 1 -- int10--------
    rs1819527161,2
    --44831389(+) CTGGCC/TAATTT 1 -- int10--------
    rs1869545851,2
    --44831461(+) TCAGGA/TGATTC 1 -- int10--------
    rs1917021471,2
    --44831485(+) TCCCAA/CAGTGC 1 -- int10--------
    rs1458582641,2
    C--44831637(+) GTCTCA/GCTCTG 1 -- int10--------
    rs1489889961,2
    C--44831760(+) CGCCCA/GGCTAA 1 -- int10--------

    HapMap Linkage Disequilibrium report for EIF3J (44829255 - 44855227 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for EIF3J: --
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing EIF3J
    DNA2.0 Custom Variant and Variant Library Synthesis for EIF3J

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 603910    OMIM disorders: --


    Find genes that share disorders with EIF3J           About GenesLikeMe


    Export disorders for EIF3J gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for EIF3J gene, integrated from 10 sources (see all 48):
    (articles sorted by number of sources associating them with EIF3J)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Characterization of cDNAs encoding the p44 and p35 subunits of human translation initiation factor eIF3. (PubMed id 9822659)1, 2, 3, 9 Block K.L.... Hershey J.W.B. (J. Biol. Chem. 1998)
    2. Mass spectrometry reveals modularity and a complete subunit interaction map of the eukaryotic translation factor eIF3. (PubMed id 18599441)1, 2 Zhou M.... Robinson C.V. (Proc. Natl. Acad. Sci. U.S.A. 2008)
    3. Structure of eIF3b RNA recognition motif and its interaction with eIF3j: structural insights into the recruitment of eIF3b to the 40 S ribosomal subunit. (PubMed id 17190833)1, 2 ElAntak L.... Lukavsky P.J. (J. Biol. Chem. 2007)
    4. eIF3j is located in the decoding center of the human 40S ribosomal subunit. (PubMed id 17588516)1, 2 Fraser C.S.... Doudna J.A. (Mol. Cell 2007)
    5. Structural characterization of the human eukaryotic initiation factor 3 protein complex by mass spectrometry. (PubMed id 17322308)1, 2 Damoc E.... Leary J.A. (Mol. Cell. Proteomics 2007)
    6. A probability-based approach for high-throughput protein phosphorylation analysis and site localization. (PubMed id 16964243)1, 2 Beausoleil S.A.... Gygi S.P. (Nat. Biotechnol. 2006)
    7. Translation initiation factor eIF4G-1 binds to eIF3 through the eIF3e subunit. (PubMed id 16766523)1, 2 LeFebvre A.K.... Rhoads R.E. (J. Biol. Chem. 2006)
    8. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)1, 2 Olsen J.V....Mann M. (Cell 2006)
    9. Binding of eukaryotic initiation factor 3 to ribosomal 40S subunits and its role in ribosomal dissociation and anti-association. (PubMed id 15703437)1, 2 Kolupaeva V.G....Pestova T.V. (RNA 2005)
    10. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 8669 HGNC: 3270 AceView: EIF3S1 Ensembl:ENSG00000104131 euGenes: HUgn8669
    ECgene: EIF3J Kegg: 8669 H-InvDB: EIF3J

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for EIF3J Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for EIF3J gene:
    Search GeneIP for patents involving EIF3J

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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