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Aliases for EIF3I Gene

Aliases for EIF3I Gene

  • Eukaryotic Translation Initiation Factor 3 Subunit I 2 3 5
  • Eukaryotic Translation Initiation Factor 3, Subunit 2 Beta, 36kDa 2 3
  • Eukaryotic Translation Initiation Factor 3 Subunit 2 3 4
  • TGF-Beta Receptor-Interacting Protein 1 3 4
  • EIF3S2 3 4
  • TRIP-1 3 4
  • TRIP1 3 4
  • Eukaryotic Translation Initiation Factor 3, Subunit 2 (Beta, 36kD) 3
  • Eukaryotic Translation Initiation Factor 3, Subunit I 2
  • TGFbeta Receptor-Interacting Protein 1 3
  • Predicted Protein Of HQ2242 3
  • EIF-3-Beta 4
  • EIF3-Beta 3
  • EIF3-P36 3
  • EIF3 P36 4
  • PRO2242 3
  • EIF3i 4

External Ids for EIF3I Gene

Previous HGNC Symbols for EIF3I Gene

  • EIF3S2

Previous GeneCards Identifiers for EIF3I Gene

  • GC01P032462
  • GC01P032687
  • GC01P030804

Summaries for EIF3I Gene

GeneCards Summary for EIF3I Gene

EIF3I (Eukaryotic Translation Initiation Factor 3 Subunit I) is a Protein Coding gene. Among its related pathways are Viral mRNA Translation and Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S. GO annotations related to this gene include translation initiation factor activity. An important paralog of this gene is STRAP.

UniProtKB/Swiss-Prot for EIF3I Gene

  • Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis (PubMed:17581632, PubMed:25849773, PubMed:27462815). The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation (PubMed:17581632). The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, including cell cycling, differentiation and apoptosis, and uses different modes of RNA stem-loop binding to exert either translational activation or repression (PubMed:25849773).

Gene Wiki entry for EIF3I Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for EIF3I Gene

Genomics for EIF3I Gene

Regulatory Elements for EIF3I Gene

Enhancers for EIF3I Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH01G031795 1.5 FANTOM5 ENCODE dbSUPER 30.6 -423.9 -423945 4.5 ATF1 ZNF493 ZFP64 TCF12 GTF3C2 GLIS2 FOS ZNF263 REST ZNF623 SNRNP40 ENSG00000229447 EIF3I TSSK3 COL16A1 ZBTB8B KPNA6 MTMR9LP PEF1 KHDRBS1
GH01G032988 2.1 FANTOM5 Ensembl ENCODE dbSUPER 21.7 +769.4 769412 6.6 HDGF PKNOX1 ARNT ZFP64 SIN3A YBX1 ZNF766 FOS KLF13 DEK RNF19B ZBTB8B EIF3I DCDC2B ENSG00000239670 KPNA6 TSSK3 AK2 AZIN2 MTMR9LP
GH01G031924 2.1 FANTOM5 Ensembl ENCODE dbSUPER 21.7 -286.0 -286035 22.1 MLX CREB3L1 AGO1 ZFP64 FEZF1 DMAP1 YBX1 YY1 SLC30A9 ZNF416 SNRNP40 ENSG00000229447 TSSK3 LOC105378626 EIF3I MTMR9LP KHDRBS1 HDAC1 ENSG00000224066 ENSG00000203325
GH01G032132 1.3 Ensembl ENCODE 30.7 -88.5 -88457 2.3 HDGF PKNOX1 CREB3L1 ARNT SIN3A ZNF766 CBX5 FOS ZNF548 KLF13 SNRNP40 KPNA6 EIF3I ENSG00000229447 IQCC TSSK3 CCDC28B ENSG00000224066 DCDC2B TMEM234
GH01G032262 1.8 FANTOM5 Ensembl ENCODE dbSUPER 21.9 +43.5 43521 4.8 HDGF ZNF493 ZFP64 ZNF121 GATA2 FOS REST ZNF623 ZNF518A MEF2D SNRNP40 EIF3I MTMR9LP ZBTB8B KPNA6 TSSK3 DCDC2B ENSG00000270115 LCK TXLNA
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around EIF3I on UCSC Golden Path with GeneCards custom track

Promoters for EIF3I Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000004333 533 1601 PKNOX1 CREB3L1 ARNT ARID4B SIN3A DMAP1 YY1 ZNF143 ZNF207 FOS

Genomic Location for EIF3I Gene

Chromosome:
1
Start:
32,221,867 bp from pter
End:
32,231,604 bp from pter
Size:
9,738 bases
Orientation:
Plus strand

Genomic View for EIF3I Gene

Genes around EIF3I on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
EIF3I Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for EIF3I Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for EIF3I Gene

Proteins for EIF3I Gene

  • Protein details for EIF3I Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q13347-EIF3I_HUMAN
    Recommended name:
    Eukaryotic translation initiation factor 3 subunit I
    Protein Accession:
    Q13347

    Protein attributes for EIF3I Gene

    Size:
    325 amino acids
    Molecular mass:
    36502 Da
    Quaternary structure:
    • Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is composed of 13 subunits: EIF3A, EIF3B, EIF3C, EIF3D, EIF3E, EIF3F, EIF3G, EIF3H, EIF3I, EIF3J, EIF3K, EIF3L and EIF3M. The eIF-3 complex appears to include 3 stable modules: module A is composed of EIF3A, EIF3B, EIF3G and EIF3I; module B is composed of EIF3F, EIF3H, and EIF3M; and module C is composed of EIF3C, EIF3D, EIF3E, EIF3K and EIF3L. EIF3C of module C binds EIF3B of module A and EIF3H of module B, thereby linking the three modules. EIF3J is a labile subunit that binds to the eIF-3 complex via EIF3B. The eIF-3 complex interacts with RPS6KB1 under conditions of nutrient depletion. Mitogenic stimulation leads to binding and activation of a complex composed of MTOR and RPTOR, leading to phosphorylation and release of RPS6KB1 and binding of EIF4B to eIF-3.

neXtProt entry for EIF3I Gene

Post-translational modifications for EIF3I Gene

  • Phosphorylated by TGF-beta type II receptor.
  • Ubiquitination at isoforms=2, isoforms=30, Lys65, Lys85, Lys91, isoforms=148, isoforms=176, Lys185, Lys208, Lys213, Lys224, isoforms=264, Lys282, and isoforms=298
  • Modification sites at PhosphoSitePlus

Other Protein References for EIF3I Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for EIF3I Gene

Domains & Families for EIF3I Gene

Graphical View of Domain Structure for InterPro Entry

Q13347

UniProtKB/Swiss-Prot:

EIF3I_HUMAN :
  • Belongs to the eIF-3 subunit I family.
Family:
  • Belongs to the eIF-3 subunit I family.
genes like me logo Genes that share domains with EIF3I: view

Function for EIF3I Gene

Molecular function for EIF3I Gene

UniProtKB/Swiss-Prot Function:
Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis (PubMed:17581632, PubMed:25849773, PubMed:27462815). The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation (PubMed:17581632). The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, including cell cycling, differentiation and apoptosis, and uses different modes of RNA stem-loop binding to exert either translational activation or repression (PubMed:25849773).

Gene Ontology (GO) - Molecular Function for EIF3I Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003743 contributes_to translation initiation factor activity IDA 25849773
GO:0005515 protein binding IPI 14688252
genes like me logo Genes that share ontologies with EIF3I: view
genes like me logo Genes that share phenotypes with EIF3I: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for EIF3I Gene

Localization for EIF3I Gene

Subcellular locations from UniProtKB/Swiss-Prot for EIF3I Gene

Cytoplasm.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for EIF3I gene
Compartment Confidence
extracellular 5
cytosol 5
nucleus 3

Gene Ontology (GO) - Cellular Components for EIF3I Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
GO:0005829 cytosol TAS --
GO:0005852 eukaryotic translation initiation factor 3 complex IDA 17322308
GO:0016282 eukaryotic 43S preinitiation complex IEA --
GO:0033290 eukaryotic 48S preinitiation complex IEA --
genes like me logo Genes that share ontologies with EIF3I: view

Pathways & Interactions for EIF3I Gene

genes like me logo Genes that share pathways with EIF3I: view

SIGNOR curated interactions for EIF3I Gene

Activates:

Gene Ontology (GO) - Biological Process for EIF3I Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006412 translation IEA --
GO:0006413 translational initiation TAS --
GO:0006446 regulation of translational initiation IEA --
genes like me logo Genes that share ontologies with EIF3I: view

Drugs & Compounds for EIF3I Gene

No Compound Related Data Available

Transcripts for EIF3I Gene

Unigene Clusters for EIF3I Gene

Eukaryotic translation initiation factor 3, subunit I:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for EIF3I Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3 ^ 4a · 4b ^ 5a · 5b · 5c ^ 6a · 6b ^ 7 ^ 8 ^ 9 ^ 10 ^ 11
SP1: - - - -
SP2: - - -
SP3: - -
SP4: - -
SP5: - - -
SP6: -

Relevant External Links for EIF3I Gene

GeneLoc Exon Structure for
EIF3I
ECgene alternative splicing isoforms for
EIF3I

Expression for EIF3I Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for EIF3I Gene

Protein differential expression in normal tissues from HIPED for EIF3I Gene

This gene is overexpressed in Peripheral blood mononuclear cells (8.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for EIF3I Gene



Protein tissue co-expression partners for EIF3I Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of EIF3I Gene:

EIF3I

SOURCE GeneReport for Unigene cluster for EIF3I Gene:

Hs.530096

Evidence on tissue expression from TISSUES for EIF3I Gene

  • Nervous system(4.9)
  • Lung(4.7)
  • Muscle(4.5)
  • Skin(4.1)
  • Liver(3.6)
  • Blood(2.9)
  • Kidney(2.9)
  • Intestine(2.8)
  • Eye(2.5)
  • Stomach(2.3)
genes like me logo Genes that share expression patterns with EIF3I: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for EIF3I Gene

Orthologs for EIF3I Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for EIF3I Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia EIF3I 35
  • 100 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia EIF3I 35
  • 97 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia EIF3I 35
  • 96 (a)
OneToOne
cow
(Bos Taurus)
Mammalia EIF3I 34 35
  • 93.44 (n)
dog
(Canis familiaris)
Mammalia EIF3I 34 35
  • 92.72 (n)
rat
(Rattus norvegicus)
Mammalia Eif3i 34
  • 91.49 (n)
mouse
(Mus musculus)
Mammalia Eif3i 34 16 35
  • 91.28 (n)
chicken
(Gallus gallus)
Aves EIF3I 34 35
  • 83.59 (n)
lizard
(Anolis carolinensis)
Reptilia EIF3I 35
  • 92 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia eif3i 34
  • 78.46 (n)
Str.5958 34
zebrafish
(Danio rerio)
Actinopterygii eif3i 34 35
  • 75.49 (n)
Dr.895 34
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.10798 34
fruit fly
(Drosophila melanogaster)
Insecta Trip1 34 35
  • 61.52 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta EIF3I_ANOGA 34
  • 59.67 (n)
worm
(Caenorhabditis elegans)
Secernentea eif-3.I 34 35
  • 50.62 (n)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_ADR264C 34
  • 53.03 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes TIF34 34 35 37
  • 52.62 (n)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0F07403g 34
  • 52.1 (n)
thale cress
(Arabidopsis thaliana)
eudicotyledons AT2G46290 34
  • 53.15 (n)
soybean
(Glycine max)
eudicotyledons Gma.3948 34
Alicante grape
(Vitis vinifera)
eudicotyledons Vvi.282 34
rice
(Oryza sativa)
Liliopsida Os05g0256000 34
  • 54.49 (n)
Os.7231 34
barley
(Hordeum vulgare)
Liliopsida Hv.2368 34
wheat
(Triticum aestivum)
Liliopsida Ta.2846 34
bread mold
(Neurospora crassa)
Ascomycetes NCU03876 34
  • 57.03 (n)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes sum1 34
  • 52.94 (n)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.4745 34
Species where no ortholog for EIF3I was found in the sources mined by GeneCards:
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)

Evolution for EIF3I Gene

ENSEMBL:
Gene Tree for EIF3I (if available)
TreeFam:
Gene Tree for EIF3I (if available)

Paralogs for EIF3I Gene

Paralogs for EIF3I Gene

(4) SIMAP similar genes for EIF3I Gene using alignment to 2 proteins:

Pseudogenes.org Pseudogenes for EIF3I Gene

genes like me logo Genes that share paralogs with EIF3I: view

Variants for EIF3I Gene

Sequence variations from dbSNP and Humsavar for EIF3I Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs1000097457 -- 32,226,247(+) ATCAT(A/G)TTCTC intron-variant, reference, missense
rs1000559671 -- 32,222,834(+) GCTCA(C/G)GCCTG intron-variant, upstream-variant-2KB
rs1000571877 -- 32,229,450(+) TCACC(G/T)TGTTA intron-variant
rs1000621551 -- 32,221,435(+) CTTGA(A/T)GCCAA intron-variant, upstream-variant-2KB
rs1000940977 -- 32,220,165(+) ATAAG(G/T)GCATA intron-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for EIF3I Gene

Variant ID Type Subtype PubMed ID
nsv300 CNV insertion 18451855

Variation tolerance for EIF3I Gene

Residual Variation Intolerance Score: 20.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.39; 8.55% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for EIF3I Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
EIF3I

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for EIF3I Gene

Disorders for EIF3I Gene

Relevant External Links for EIF3I

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
EIF3I

No disorders were found for EIF3I Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for EIF3I Gene

Publications for EIF3I Gene

  1. Conservation and diversity of eukaryotic translation initiation factor eIF3. (PMID: 8995409) Asano K. … Hershey J.W.B. (J. Biol. Chem. 1997) 2 3 4 22 64
  2. A WD-domain protein that is associated with and phosphorylated by the type II TGF-beta receptor. (PMID: 7566156) Chen R.H. … Derynck R. (Nature 1995) 2 3 4 64
  3. eIF3 targets cell-proliferation messenger RNAs for translational activation or repression. (PMID: 25849773) Lee A.S. … Cate J.H. (Nature 2015) 3 4 64
  4. Higher TRIP-1 level explains diminished collagen contraction ability of fetal versus adult fibroblasts. (PMID: 19329541) Navarro A. … Ekekezie I.I. (Am. J. Physiol. Lung Cell Mol. Physiol. 2009) 3 22 64
  5. Mass spectrometry reveals modularity and a complete subunit interaction map of the eukaryotic translation factor eIF3. (PMID: 18599441) Zhou M. … Robinson C.V. (Proc. Natl. Acad. Sci. U.S.A. 2008) 3 4 64

Products for EIF3I Gene

Sources for EIF3I Gene

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