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Aliases for EIF3I Gene

Aliases for EIF3I Gene

  • Eukaryotic Translation Initiation Factor 3, Subunit I 2 3
  • EIF3S2 3 4 6
  • TRIP1 3 4 6
  • Eukaryotic Translation Initiation Factor 3, Subunit 2 Beta, 36kDa 2 3
  • Eukaryotic Translation Initiation Factor 3 Subunit 2 3 4
  • TGF-Beta Receptor-Interacting Protein 1 3 4
  • EIF-3-Beta 3 4
  • EIF3 P36 3 4
  • TRIP-1 3 4
  • Eukaryotic Translation Initiation Factor 3, Subunit 2 (Beta, 36kD) 3
  • Eukaryotic Translation Initiation Factor 3 Subunit I 3
  • TGFbeta Receptor-Interacting Protein 1 3
  • Predicted Protein Of HQ2242 3
  • EIF3-Beta 3
  • EIF3-P36 3
  • PRO2242 3
  • EIF3i 4

External Ids for EIF3I Gene

Previous HGNC Symbols for EIF3I Gene

  • EIF3S2

Previous GeneCards Identifiers for EIF3I Gene

  • GC01P032462
  • GC01P032687
  • GC01P030804

Summaries for EIF3I Gene

GeneCards Summary for EIF3I Gene

EIF3I (Eukaryotic Translation Initiation Factor 3, Subunit I) is a Protein Coding gene. Diseases associated with EIF3I include clonorchiasis. Among its related pathways are p70S6K Signaling and Apoptotic Pathways in Synovial Fibroblasts. GO annotations related to this gene include translation initiation factor activity. An important paralog of this gene is STRAP.

UniProtKB/Swiss-Prot for EIF3I Gene

  • Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S preinitiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation

Gene Wiki entry for EIF3I Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for EIF3I Gene

Genomics for EIF3I Gene

Regulatory Elements for EIF3I Gene

Genomic Location for EIF3I Gene

Start:
32,221,928 bp from pter
End:
32,231,604 bp from pter
Size:
9,677 bases
Orientation:
Plus strand

Genomic View for EIF3I Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for EIF3I Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for EIF3I Gene

Proteins for EIF3I Gene

  • Protein details for EIF3I Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q13347-EIF3I_HUMAN
    Recommended name:
    Eukaryotic translation initiation factor 3 subunit I
    Protein Accession:
    Q13347
    Secondary Accessions:

    Protein attributes for EIF3I Gene

    Size:
    325 amino acids
    Molecular mass:
    36502 Da
    Quaternary structure:
    • Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is composed of 13 subunits: EIF3A, EIF3B, EIF3C, EIF3D, EIF3E, EIF3F, EIF3G, EIF3H, EIF3I, EIF3J, EIF3K, EIF3L and EIF3M. The eIF-3 complex appears to include 3 stable modules: module A is composed of EIF3A, EIF3B, EIF3G and EIF3I; module B is composed of EIF3F, EIF3H, and EIF3M; and module C is composed of EIF3C, EIF3D, EIF3E, EIF3K and EIF3L. EIF3C of module C binds EIF3B of module A and EIF3H of module B, thereby linking the three modules. EIF3J is a labile subunit that binds to the eIF-3 complex via EIF3B. The eIF-3 complex interacts with RPS6KB1 under conditions of nutrient depletion. Mitogenic stimulation leads to binding and activation of a complex composed of MTOR and RPTOR, leading to phosphorylation and release of RPS6KB1 and binding of EIF4B to eIF-3.

neXtProt entry for EIF3I Gene

Proteomics data for EIF3I Gene at MOPED

Post-translational modifications for EIF3I Gene

  • Phosphorylated by TGF-beta type II receptor.
  • Ubiquitination at Lys30, Lys65, Lys85, Lys91, Lys148, Lys176, Lys185, Lys208, Lys213, Lys224, Lys264, Lys282, and Lys298
  • Modification sites at PhosphoSitePlus

Other Protein References for EIF3I Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for EIF3I Gene

Domains for EIF3I Gene

Gene Families for EIF3I Gene

HGNC:
  • WDR :WD repeat domain containing

Suggested Antigen Peptide Sequences for EIF3I Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q13347

UniProtKB/Swiss-Prot:

EIF3I_HUMAN :
  • Q13347
Family:
  • Belongs to the eIF-3 subunit I family.
Similarity:
  • Contains 7 WD repeats.
genes like me logo Genes that share domains with EIF3I: view

Function for EIF3I Gene

Molecular function for EIF3I Gene

UniProtKB/Swiss-Prot Function: Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S preinitiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation

Gene Ontology (GO) - Molecular Function for EIF3I Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003743 translation initiation factor activity IDA 17581632
GO:0005515 protein binding IPI 14688252
genes like me logo Genes that share ontologies with EIF3I: view
genes like me logo Genes that share phenotypes with EIF3I: view

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for EIF3I Gene

Localization for EIF3I Gene

Subcellular locations from UniProtKB/Swiss-Prot for EIF3I Gene

Cytoplasm.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for EIF3I Gene COMPARTMENTS Subcellular localization image for EIF3I gene
Compartment Confidence
cytosol 4
nucleus 2

Gene Ontology (GO) - Cellular Components for EIF3I Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005829 cytosol TAS --
GO:0005852 eukaryotic translation initiation factor 3 complex IDA 17322308
GO:0016282 eukaryotic 43S preinitiation complex IEA --
GO:0033290 eukaryotic 48S preinitiation complex IEA --
GO:0070062 extracellular exosome IDA 20458337
genes like me logo Genes that share ontologies with EIF3I: view

Pathways for EIF3I Gene

genes like me logo Genes that share pathways with EIF3I: view

Pathways by source for EIF3I Gene

Gene Ontology (GO) - Biological Process for EIF3I Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001731 formation of translation preinitiation complex IEA --
GO:0006412 translation TAS --
GO:0006413 translational initiation TAS --
GO:0006446 regulation of translational initiation IEA --
GO:0010467 gene expression TAS --
genes like me logo Genes that share ontologies with EIF3I: view

Transcripts for EIF3I Gene

Unigene Clusters for EIF3I Gene

Eukaryotic translation initiation factor 3, subunit I:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for EIF3I Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3 ^ 4a · 4b ^ 5a · 5b · 5c ^ 6a · 6b ^ 7 ^ 8 ^ 9 ^ 10 ^ 11
SP1: - - - -
SP2: - - -
SP3: - -
SP4: - -
SP5: - - -
SP6: -

Relevant External Links for EIF3I Gene

GeneLoc Exon Structure for
EIF3I
ECgene alternative splicing isoforms for
EIF3I

Expression for EIF3I Gene

mRNA expression in normal human tissues for EIF3I Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for EIF3I Gene

SOURCE GeneReport for Unigene cluster for EIF3I Gene Hs.530096

genes like me logo Genes that share expressions with EIF3I: view

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for EIF3I Gene

Orthologs for EIF3I Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for EIF3I Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia EIF3I 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia EIF3I 35
  • 93.44 (n)
  • 99.08 (a)
EIF3I 36
  • 99 (a)
OneToOne
dog
(Canis familiaris)
Mammalia EIF3I 35
  • 92.72 (n)
  • 99.38 (a)
EIF3I 36
  • 99 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Eif3i 35
  • 91.28 (n)
  • 99.38 (a)
Eif3i 16
Eif3i 36
  • 99 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia EIF3I 36
  • 97 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia EIF3I 36
  • 96 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Eif3i 35
  • 91.49 (n)
  • 99.38 (a)
chicken
(Gallus gallus)
Aves EIF3I 35
  • 83.59 (n)
  • 94.15 (a)
EIF3I 36
  • 94 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia EIF3I 36
  • 92 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia eif3i 35
  • 78.46 (n)
  • 90.15 (a)
Str.5958 35
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.10798 35
zebrafish
(Danio rerio)
Actinopterygii Dr.895 35
eif3i 35
  • 75.49 (n)
  • 83.69 (a)
eif3i 36
  • 84 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta EIF3I_ANOGA 35
  • 59.67 (n)
  • 57.72 (a)
fruit fly
(Drosophila melanogaster)
Insecta Trip1 35
  • 61.52 (n)
  • 61.11 (a)
Trip1 36
  • 60 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea eif-3.I 35
  • 50.62 (n)
  • 43.52 (a)
eif-3.I 36
  • 43 (a)
OneToOne
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_ADR264C 35
  • 53.03 (n)
  • 45.85 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes TIF34 35
  • 52.62 (n)
  • 46.15 (a)
TIF34 36
  • 44 (a)
OneToMany
TIF34 38
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0F07403g 35
  • 52.1 (n)
  • 45.54 (a)
Alicante grape
(Vitis vinifera)
eudicotyledons Vvi.282 35
soybean
(Glycine max)
eudicotyledons Gma.3948 35
thale cress
(Arabidopsis thaliana)
eudicotyledons AT2G46290 35
  • 53.15 (n)
  • 47.37 (a)
barley
(Hordeum vulgare)
Liliopsida Hv.2368 35
rice
(Oryza sativa)
Liliopsida Os.7231 35
Os05g0256000 35
  • 54.49 (n)
  • 46.44 (a)
wheat
(Triticum aestivum)
Liliopsida Ta.2846 35
bread mold
(Neurospora crassa)
Ascomycetes NCU03876 35
  • 57.03 (n)
  • 52 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes sum1 35
  • 52.94 (n)
  • 49.54 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.4745 35
Species with no ortholog for EIF3I:
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)

Evolution for EIF3I Gene

ENSEMBL:
Gene Tree for EIF3I (if available)
TreeFam:
Gene Tree for EIF3I (if available)

Paralogs for EIF3I Gene

Paralogs for EIF3I Gene

Selected SIMAP similar genes for EIF3I Gene using alignment to 2 proteins:

Pseudogenes.org Pseudogenes for EIF3I Gene

genes like me logo Genes that share paralogs with EIF3I: view

Variants for EIF3I Gene

Sequence variations from dbSNP and Humsavar for EIF3I Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
rs1298303 -- 32,224,784(-) ctgag(A/G)cagga intron-variant
rs1298304 -- 32,225,045(-) accag(C/T)ctggc intron-variant
rs1299547 -- 32,224,690(-) gtctc(A/C)aaaat intron-variant
rs7546344 -- 32,230,051(+) TATAA(C/T)AAAAA intron-variant
rs11554217 -- 32,226,278(+) ACCAG(C/T)GCTTT missense, reference

Structural Variations from Database of Genomic Variants (DGV) for EIF3I Gene

Variant ID Type Subtype PubMed ID
nsv300 CNV Insertion 18451855

Relevant External Links for EIF3I Gene

HapMap Linkage Disequilibrium report
EIF3I

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for EIF3I Gene

Disorders for EIF3I Gene

MalaCards: The human disease database

MalaCards: The human disease database. (1) Diseases for EIF3I Gene including...

Search for EIF3I Gene in MalaCards »

(1) University of Copenhagen DISEASES for EIF3I Gene

genes like me logo Genes that share disorders with EIF3I: view

No data available for UniProtKB/Swiss-Prot for EIF3I Gene

Publications for EIF3I Gene

  1. Conservation and diversity of eukaryotic translation initiation factor eIF3. (PMID: 8995409) Asano K. … Hershey J.W.B. (J. Biol. Chem. 1997) 2 3 4 23
  2. A WD-domain protein that is associated with and phosphorylated by the type II TGF-beta receptor. (PMID: 7566156) Chen R.H. … Derynck R. (Nature 1995) 2 3 4
  3. Higher TRIP-1 level explains diminished collagen contraction ability of fetal versus adult fibroblasts. (PMID: 19329541) Navarro A. … Ekekezie I.I. (Am. J. Physiol. Lung Cell Mol. Physiol. 2009) 3 23
  4. Structural characterization of the human eukaryotic initiation factor 3 protein complex by mass spectrometry. (PMID: 17322308) Damoc E. … Leary J.A. (Mol. Cell. Proteomics 2007) 3 4
  5. Reconstitution reveals the functional core of mammalian eIF3. (PMID: 17581632) Masutani M. … Imataka H. (EMBO J. 2007) 3 4

Products for EIF3I Gene

Sources for EIF3I Gene

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