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Aliases for EIF3I Gene

Aliases for EIF3I Gene

  • Eukaryotic Translation Initiation Factor 3 Subunit I 2 3 5
  • Eukaryotic Translation Initiation Factor 3, Subunit 2 Beta, 36kDa 2 3
  • Eukaryotic Translation Initiation Factor 3, Subunit I 2 3
  • Eukaryotic Translation Initiation Factor 3 Subunit 2 3 4
  • TGF-Beta Receptor-Interacting Protein 1 3 4
  • EIF3S2 3 4
  • TRIP-1 3 4
  • TRIP1 3 4
  • Eukaryotic Translation Initiation Factor 3, Subunit 2 (Beta, 36kD) 3
  • TGFbeta Receptor-Interacting Protein 1 3
  • Predicted Protein Of HQ2242 3
  • EIF-3-Beta 4
  • EIF3-Beta 3
  • EIF3-P36 3
  • EIF3 P36 4
  • PRO2242 3
  • EIF3i 4

External Ids for EIF3I Gene

Previous HGNC Symbols for EIF3I Gene

  • EIF3S2

Previous GeneCards Identifiers for EIF3I Gene

  • GC01P032462
  • GC01P032687
  • GC01P030804

Summaries for EIF3I Gene

GeneCards Summary for EIF3I Gene

EIF3I (Eukaryotic Translation Initiation Factor 3 Subunit I) is a Protein Coding gene. Among its related pathways are Gene Expression and Transport to the Golgi and subsequent modification. GO annotations related to this gene include translation initiation factor activity. An important paralog of this gene is STRAP.

UniProtKB/Swiss-Prot for EIF3I Gene

  • Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S preinitiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation.

Gene Wiki entry for EIF3I Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for EIF3I Gene

Genomics for EIF3I Gene

Regulatory Elements for EIF3I Gene

Promoters for EIF3I Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around EIF3I on UCSC Golden Path with GeneCards custom track

Genomic Location for EIF3I Gene

Chromosome:
1
Start:
32,221,867 bp from pter
End:
32,231,604 bp from pter
Size:
9,738 bases
Orientation:
Plus strand

Genomic View for EIF3I Gene

Genes around EIF3I on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
EIF3I Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for EIF3I Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for EIF3I Gene

Proteins for EIF3I Gene

  • Protein details for EIF3I Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q13347-EIF3I_HUMAN
    Recommended name:
    Eukaryotic translation initiation factor 3 subunit I
    Protein Accession:
    Q13347

    Protein attributes for EIF3I Gene

    Size:
    325 amino acids
    Molecular mass:
    36502 Da
    Quaternary structure:
    • Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is composed of 13 subunits: EIF3A, EIF3B, EIF3C, EIF3D, EIF3E, EIF3F, EIF3G, EIF3H, EIF3I, EIF3J, EIF3K, EIF3L and EIF3M. The eIF-3 complex appears to include 3 stable modules: module A is composed of EIF3A, EIF3B, EIF3G and EIF3I; module B is composed of EIF3F, EIF3H, and EIF3M; and module C is composed of EIF3C, EIF3D, EIF3E, EIF3K and EIF3L. EIF3C of module C binds EIF3B of module A and EIF3H of module B, thereby linking the three modules. EIF3J is a labile subunit that binds to the eIF-3 complex via EIF3B. The eIF-3 complex interacts with RPS6KB1 under conditions of nutrient depletion. Mitogenic stimulation leads to binding and activation of a complex composed of MTOR and RPTOR, leading to phosphorylation and release of RPS6KB1 and binding of EIF4B to eIF-3.

neXtProt entry for EIF3I Gene

Proteomics data for EIF3I Gene at MOPED

Post-translational modifications for EIF3I Gene

  • Phosphorylated by TGF-beta type II receptor.
  • Ubiquitination at Lys 2, Lys 30, Lys 65, Lys 85, Lys 91, Lys 148, Lys 176, Lys 185, Lys 208, Lys 213, Lys 224, Lys 264, Lys 282, and Lys 298
  • Modification sites at PhosphoSitePlus

Other Protein References for EIF3I Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for EIF3I Gene

Domains & Families for EIF3I Gene

Graphical View of Domain Structure for InterPro Entry

Q13347

UniProtKB/Swiss-Prot:

EIF3I_HUMAN :
  • Belongs to the eIF-3 subunit I family.
  • Contains 7 WD repeats.
Family:
  • Belongs to the eIF-3 subunit I family.
Similarity:
  • Contains 7 WD repeats.
genes like me logo Genes that share domains with EIF3I: view

Function for EIF3I Gene

Molecular function for EIF3I Gene

UniProtKB/Swiss-Prot Function:
Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S preinitiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation.
genes like me logo Genes that share phenotypes with EIF3I: view

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for EIF3I Gene

Localization for EIF3I Gene

Subcellular locations from UniProtKB/Swiss-Prot for EIF3I Gene

Cytoplasm.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for EIF3I Gene COMPARTMENTS Subcellular localization image for EIF3I gene
Compartment Confidence
cytosol 5
extracellular 5
nucleus 3

Gene Ontology (GO) - Cellular Components for EIF3I Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005852 eukaryotic translation initiation factor 3 complex IEA,IDA 17322308
GO:0033290 eukaryotic 48S preinitiation complex IEA --
genes like me logo Genes that share ontologies with EIF3I: view

Pathways & Interactions for EIF3I Gene

genes like me logo Genes that share pathways with EIF3I: view

Pathways by source for EIF3I Gene

SIGNOR curated interactions for EIF3I Gene

Activates:

Gene Ontology (GO) - Biological Process for EIF3I Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006413 translational initiation IEA,TAS --
GO:0006446 regulation of translational initiation IEA --
genes like me logo Genes that share ontologies with EIF3I: view

Drugs & Compounds for EIF3I Gene

No Compound Related Data Available

Transcripts for EIF3I Gene

Unigene Clusters for EIF3I Gene

Eukaryotic translation initiation factor 3, subunit I:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for EIF3I Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3 ^ 4a · 4b ^ 5a · 5b · 5c ^ 6a · 6b ^ 7 ^ 8 ^ 9 ^ 10 ^ 11
SP1: - - - -
SP2: - - -
SP3: - -
SP4: - -
SP5: - - -
SP6: -

Relevant External Links for EIF3I Gene

GeneLoc Exon Structure for
EIF3I
ECgene alternative splicing isoforms for
EIF3I

Expression for EIF3I Gene

mRNA expression in normal human tissues for EIF3I Gene

Protein differential expression in normal tissues from HIPED for EIF3I Gene

This gene is overexpressed in Peripheral blood mononuclear cells (8.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for EIF3I Gene



SOURCE GeneReport for Unigene cluster for EIF3I Gene Hs.530096

genes like me logo Genes that share expression patterns with EIF3I: view

Protein tissue co-expression partners for EIF3I Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for EIF3I Gene

Orthologs for EIF3I Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for EIF3I Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia EIF3I 35
  • 93.44 (n)
  • 99.08 (a)
EIF3I 36
  • 99 (a)
OneToOne
dog
(Canis familiaris)
Mammalia EIF3I 35
  • 92.72 (n)
  • 99.38 (a)
EIF3I 36
  • 99 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Eif3i 35
  • 91.28 (n)
  • 99.38 (a)
Eif3i 16
Eif3i 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Eif3i 35
  • 91.49 (n)
  • 99.38 (a)
oppossum
(Monodelphis domestica)
Mammalia EIF3I 36
  • 97 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia EIF3I 36
  • 96 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia EIF3I 36
  • 100 (a)
OneToOne
chicken
(Gallus gallus)
Aves EIF3I 35
  • 83.59 (n)
  • 94.15 (a)
EIF3I 36
  • 94 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia EIF3I 36
  • 92 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia eif3i 35
  • 78.46 (n)
  • 90.15 (a)
Str.5958 35
zebrafish
(Danio rerio)
Actinopterygii Dr.895 35
eif3i 35
  • 75.49 (n)
  • 83.69 (a)
eif3i 36
  • 84 (a)
OneToOne
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.10798 35
African malaria mosquito
(Anopheles gambiae)
Insecta EIF3I_ANOGA 35
  • 59.67 (n)
  • 57.72 (a)
fruit fly
(Drosophila melanogaster)
Insecta Trip1 35
  • 61.52 (n)
  • 61.11 (a)
Trip1 36
  • 60 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea eif-3.I 35
  • 50.62 (n)
  • 43.52 (a)
eif-3.I 36
  • 43 (a)
OneToOne
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_ADR264C 35
  • 53.03 (n)
  • 45.85 (a)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0F07403g 35
  • 52.1 (n)
  • 45.54 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes TIF34 35
  • 52.62 (n)
  • 46.15 (a)
TIF34 36
  • 44 (a)
OneToMany
TIF34 38
thale cress
(Arabidopsis thaliana)
eudicotyledons AT2G46290 35
  • 53.15 (n)
  • 47.37 (a)
soybean
(Glycine max)
eudicotyledons Gma.3948 35
Alicante grape
(Vitis vinifera)
eudicotyledons Vvi.282 35
barley
(Hordeum vulgare)
Liliopsida Hv.2368 35
rice
(Oryza sativa)
Liliopsida Os.7231 35
Os05g0256000 35
  • 54.49 (n)
  • 46.44 (a)
wheat
(Triticum aestivum)
Liliopsida Ta.2846 35
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.4745 35
bread mold
(Neurospora crassa)
Ascomycetes NCU03876 35
  • 57.03 (n)
  • 52 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes sum1 35
  • 52.94 (n)
  • 49.54 (a)
Species with no ortholog for EIF3I:
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)

Evolution for EIF3I Gene

ENSEMBL:
Gene Tree for EIF3I (if available)
TreeFam:
Gene Tree for EIF3I (if available)

Paralogs for EIF3I Gene

Paralogs for EIF3I Gene

(4) SIMAP similar genes for EIF3I Gene using alignment to 2 proteins:

Pseudogenes.org Pseudogenes for EIF3I Gene

genes like me logo Genes that share paralogs with EIF3I: view

Variants for EIF3I Gene

Sequence variations from dbSNP and Humsavar for EIF3I Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs1298303 -- 32,224,784(-) ctgag(A/G)cagga intron-variant
rs1298304 -- 32,225,045(-) accag(C/T)ctggc intron-variant
rs1299547 -- 32,224,690(-) gtctc(A/C)aaaat intron-variant
rs7546344 -- 32,230,051(+) TATAA(C/T)AAAAA intron-variant
rs12024003 -- 32,225,787(+) ggagg(C/T)tgagg intron-variant

Structural Variations from Database of Genomic Variants (DGV) for EIF3I Gene

Variant ID Type Subtype PubMed ID
nsv300 CNV Insertion 18451855

Variation tolerance for EIF3I Gene

Residual Variation Intolerance Score: 20.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.39; 8.55% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for EIF3I Gene

HapMap Linkage Disequilibrium report
EIF3I

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for EIF3I Gene

Disorders for EIF3I Gene

Relevant External Links for EIF3I

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
EIF3I

No disorders were found for EIF3I Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for EIF3I Gene

Publications for EIF3I Gene

  1. Conservation and diversity of eukaryotic translation initiation factor eIF3. (PMID: 8995409) Asano K. … Hershey J.W.B. (J. Biol. Chem. 1997) 2 3 4 23 67
  2. Higher TRIP-1 level explains diminished collagen contraction ability of fetal versus adult fibroblasts. (PMID: 19329541) Navarro A. … Ekekezie I.I. (Am. J. Physiol. Lung Cell Mol. Physiol. 2009) 3 23
  3. Genomic structure and chromosomal location of the human TGFbeta-receptor interacting protein-1 (TRIP-1) gene to 1p34.1. (PMID: 9599024) Galli-Stauber C. … Sorrentino V. (FEBS Lett. 1998) 3 23
  4. The type II transforming growth factor (TGF)-beta receptor-interacting protein TRIP-1 acts as a modulator of the TGF-beta response. (PMID: 9813058) Choy L. … Derynck R. (J. Biol. Chem. 1998) 3 23
  5. A WD-domain protein that is associated with and phosphorylated by the type II TGF-beta receptor. (PMID: 7566156) Chen R.H. … Derynck R. (Nature 1995) 2 3

Products for EIF3I Gene

Sources for EIF3I Gene

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