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EIF3I Gene

protein-coding   GIFtS: 60
GCID: GC01P032687

Eukaryotic Translation Initiation Factor 3, Subunit I

(Previous names: eukaryotic translation initiation factor 3, subunit 2 beta,...)
(Previous symbol: EIF3S2)
  See EIF3I-related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Eukaryotic Translation Initiation Factor 3, Subunit I1 2     PRO22422
EIF3S21 2 3 5     eIF3-beta2
TRIP12 3 5     eIF3-p362
Eukaryotic Translation Initiation Factor 3, Subunit 2 Beta, 36kDa1 2     Eukaryotic Translation Initiation Factor 3 Subunit I2
Eukaryotic Translation Initiation Factor 3 Subunit 22 3     Eukaryotic Translation Initiation Factor 3, Subunit 2 (Beta, 36kD)2
TRIP-12 3     Predicted Protein Of HQ22422
eIF-3-beta2 3     TGFbeta Receptor-Interacting Protein 12
EIF3 P362 3     eIF3i3
TGF-Beta Receptor-Interacting Protein 12 3     

External Ids:    HGNC: 32721   Entrez Gene: 86682   Ensembl: ENSG000000846237   OMIM: 6039115   UniProtKB: Q133473   

Export aliases for EIF3I gene to outside databases

Previous GC identifers: GC01P032462 GC01P030804


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for EIF3I Gene:
EIF3I (eukaryotic translation initiation factor 3, subunit I) is a protein-coding gene. Diseases associated with EIF3I include clonorchiasis. GO annotations related to this gene include translation initiation factor activity. An important paralog of this gene is STRAP.

UniProtKB/Swiss-Prot: EIF3I_HUMAN, Q13347
Function: Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for
several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and
facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S preinitiation
complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG
recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal
complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation

Gene Wiki entry for EIF3I Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000001.10  NC_018912.2  NT_032977.10  
Regulatory elements:
   Regulatory transcription factor binding sites in the EIF3I gene promoter:
         Sox5   AML1a   ATF-2   HSF1 (long)   FOXD1   YY1   E47   HSF1short   c-Jun   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidEIF3I promoter sequence
   Search Chromatin IP Primers for EIF3I

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat EIF3I


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1p34.1   Ensembl cytogenetic band:  1p35.1   HGNC cytogenetic band: 1p34.1

EIF3I Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
EIF3I gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01P032687:  view genomic region     (about GC identifiers)

Start:
32,687,529 bp from pter      End:
32,697,205 bp from pter
Size:
9,677 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: EIF3I_HUMAN, Q13347 (See protein sequence)
Recommended Name: Eukaryotic translation initiation factor 3 subunit I  
Size: 325 amino acids; 36502 Da
Subunit: Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is composed of 13
subunits: EIF3A, EIF3B, EIF3C, EIF3D, EIF3E, EIF3F, EIF3G, EIF3H, EIF3I, EIF3J, EIF3K, EIF3L and EIF3M. The eIF-3
complex appears to include 3 stable modules: module A is composed of EIF3A, EIF3B, EIF3G and EIF3I; module B is
composed of EIF3F, EIF3H, and EIF3M; and module C is composed of EIF3C, EIF3D, EIF3E, EIF3K and EIF3L. EIF3C of
module C binds EIF3B of module A and EIF3H of module B, thereby linking the three modules. EIF3J is a labile
subunit that binds to the eIF-3 complex via EIF3B. The eIF-3 complex interacts with RPS6KB1 under conditions of
nutrient depletion. Mitogenic stimulation leads to binding and activation of a complex composed of MTOR and
RPTOR, leading to phosphorylation and release of RPS6KB1 and binding of EIF4B to eIF-3
Mass spectrometry: Mass=36501.9; Method=Unknown; Range=1-325; Source=PubMed:17322308;
Mass spectrometry: Mass=36503.2; Mass_error=0.4; Method=MALDI; Range=1-325; Source=PubMed:18599441;

Explore the universe of human proteins at neXtProt for EIF3I: NX_Q13347

Explore proteomics data for EIF3I at MOPED

Post-translational modifications: 

  • Phosphorylated by TGF-beta type II receptor1
  • Ubiquitination2 at Lys30, Lys65, Lys85, Lys91, Lys148, Lys176, Lys185, Lys208, Lys213, Lys224,
                                 Lys264, Lys282, Lys298
  • Modification sites at PhosphoSitePlus

  • See EIF3I Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_003748.1  
    ENSEMBL proteins: 
     ENSP00000347194   ENSP00000362688  
    Reactome Protein details: Q13347

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    WDR: WD repeat domain containing

    5 InterPro protein domains:
     IPR027525 eIF3i
     IPR019775 WD40_repeat_CS
     IPR001680 WD40_repeat
     IPR017986 WD40_repeat_dom
     IPR015943 WD40/YVTN_repeat-like_dom

    Graphical View of Domain Structure for InterPro Entry Q13347

    ProtoNet protein and cluster: Q13347

    1 Blocks protein domain: IPB001680 G-protein beta WD-40 repeat signature

    UniProtKB/Swiss-Prot: EIF3I_HUMAN, Q13347
    Similarity: Belongs to the eIF-3 subunit I family
    Similarity: Contains 5 WD repeats


    Find genes that share domains with EIF3I           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: EIF3I_HUMAN, Q13347
    Function: Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for
    several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and
    facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S preinitiation
    complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG
    recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal
    complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003743translation initiation factor activity IDA17581632
    GO:0005515protein binding IPI14688252
         
    Find genes that share ontologies with EIF3I           About GenesLikeMe


    Phenotypes:
         6 GenomeRNAi human phenotypes for EIF3I:
     Decreased G3BP1 protein expres  Decreased viability of wild-ty  Increased S DNA content  Nuclear 60S biogenesis defects 
     Nucleolar pre-40S maturation d  S arrest 

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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    EIF3I_HUMAN, Q13347: Cytoplasm (By similarity)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol4
    nucleus2

    Gene Ontology (GO): 5 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005829cytosol TAS--
    GO:0005852eukaryotic translation initiation factor 3 complex IDA17322308
    GO:0016282eukaryotic 43S preinitiation complex IEA--
    GO:0033290eukaryotic 48S preinitiation complex IEA--
    GO:0070062extracellular vesicular exosome IDA--

    Find genes that share ontologies with EIF3I           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for EIF3I About   (see all 7)  
    See pathways by source

    SuperPathContained pathways About
    1Influenza Viral RNA Transcription and Replication
    L13a-mediated translational silencing of Ceruloplasmin expression0.94
    Cap-dependent Translation Initiation0.89
    Formation of a pool of free 40S subunits0.94
    Eukaryotic Translation Initiation0.89
    GTP hydrolysis and joining of the 60S ribosomal subunit0.93
    Translation0.82
    2Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S
    Translation initiation complex formation0.91
    Formation of the ternary complex, and subsequently, the 43S complex0.91
    Ribosomal scanning and start codon recognition0.91
    Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S0.90
    3Gene Expression
    Gene Expression0.40
    4Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein
    Metabolism of proteins0.30
    5Translation Factors
    Translation Factors


    Find genes that share SuperPaths with EIF3I           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    2 Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for EIF3I
        eIF2 Pathway
    mTOR Pathway

    2 BioSystems Pathways for EIF3I
        Translation Factors
    TGF-beta Receptor Signaling Pathway


    Selected Reactome Pathways for EIF3I (see all 6)
        Formation of the ternary complex, and subsequently, the 43S complex
    L13a-mediated translational silencing of Ceruloplasmin expression
    GTP hydrolysis and joining of the 60S ribosomal subunit
    Ribosomal scanning and start codon recognition
    Formation of a pool of free 40S subunits


    1 Kegg Pathway  (Kegg details for EIF3I):
        RNA transport

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for EIF3I
    Interactions:

        GeneGlobe Interaction Network for EIF3I

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for EIF3I (Q133471, 2, 3 ENSP000003626884) via UniProtKB, MINT, STRING, and/or I2D (see all 1003)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    EIF3BP558841, 2, 3, ENSP000003541254EBI-354047,EBI-366696 MINT-7947479 I2D: score=13 STRING: ENSP00000354125
    ENSG00000096150P622692, 3MINT-7945693 I2D: score=1 
    ENSG00000223367P622692, 3MINT-7945693 I2D: score=1 
    ENSG00000226225P622692, 3MINT-7945693 I2D: score=1 
    ENSG00000235650P622692, 3MINT-7945693 I2D: score=1 
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001731formation of translation preinitiation complex IEA--
    GO:0006412translation TAS--
    GO:0006413translational initiation TAS--
    GO:0006446regulation of translational initiation IEA--
    GO:0010467gene expression TAS--

    Find genes that share ontologies with EIF3I           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for EIF3I



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for EIF3I gene: 
    NM_003757.2  

    Unigene Cluster for EIF3I:

    Eukaryotic translation initiation factor 3, subunit I
    Hs.530096  [show with all ESTs]
    Unigene Representative Sequence: AK289882
    6 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000355082 ENST00000373586(uc001bur.4 uc009vuc.3) ENST00000489353
    ENST00000471486 ENST00000483517 ENST00000474371
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    Additional mRNA sequence: 

    AF116697.1 AK130633.1 AK222483.1 AK225024.1 AK289356.1 AK289882.1 BC000413.2 BC003140.1 
    BC018815.2 BT019597.1 U36764.1 U39067.1 

    Selected DOTS entries (see all 35):

    DT.95364979  DT.91772437  DT.92376315  DT.91709186  DT.100036258  DT.100881069  DT.100881082  DT.121372550 
    DT.100881093  DT.100881097  DT.91772427  DT.100881086  DT.92363422  DT.95367904  DT.100881089  DT.87008676 
    DT.91680266  DT.100881087  DT.121372526  DT.121372532  DT.100800134  DT.100881079  DT.101985645  DT.121372541 

    23 AceView cDNA sequences:

    CR607032 BC018815 BC000413 CR600827 CR616788 CR622680 CR603111 CR619600 
    CR612231 CR618012 CR617123 CR614021 CR593343 CR620781 CR592343 CR605302 
    CR606359 CR608953 BC003140 AF116697 U39067 AK130633 NM_003757 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for EIF3I (see all 6)    About this scheme

    ExUns: 1a · 1b ^ 2a · 2b ^ 3 ^ 4a · 4b ^ 5a · 5b · 5c ^ 6a · 6b ^ 7 ^ 8 ^ 9 ^ 10 ^ 11
    SP1:              -                       -     -     -                                                   
    SP2:                                      -     -     -                                                   
    SP3:                                      -     -                                                         
    SP4:              -                       -                                                               
    SP5:              -                       -     -                                                         


    ECgene alternative splicing isoforms for EIF3I

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    EIF3I expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GAGAAACCTC
    EIF3I Expression
    About this image


    EIF3I expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 20) fully expand
     
     Brain (Nervous System)    fully expand to see all 3 entries
             Cerebral Cortex
     
     Testis (Reproductive System)
             Leydig Cells Testis Interstitium
     
     Liver (Hepatobiliary System)
             Hepatocytes Liver Lobule
     
     Ovary (Reproductive System)
             Oviduct
     
     Pancreas (Endocrine System)
             Islets of Langerhans
    EIF3I Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    EIF3I Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.530096
        Custom PCR Arrays for EIF3I
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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of eukaryotes.

    Orthologs for EIF3I gene from Selected species (see all 28)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Eif3i1 , 5 eukaryotic translation initiation factor 3, subunit more1, 5 91.28(n)1
    99.38(a)1
      4 (63.26 cM)5
    547091  NM_018799.21  NP_061269.11 
     1295919605 
    chicken
    (Gallus gallus)
    Aves EIF3I1 eukaryotic translation initiation factor 3, subunit more 83.59(n)
    94.15(a)
      419653  NM_001164395.1  NP_001157867.1 
    lizard
    (Anolis carolinensis)
    Reptilia EIF3I6
    eukaryotic translation initiation factor 3, subuni...
    92(a)
    1 ↔ 1
    GL343706.1(102871-109693)
    African clawed frog
    (Xenopus laevis)
    Amphibia BQ732410.12   -- 77.53(n)    BQ732410.1 
    zebrafish
    (Danio rerio)
    Actinopterygii Dr.8952 Danio rerio mRNA similar to eukaryotic translation more 76.56(n)    BC045995.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Trip11 Trip1 61.52(n)
    61.11(a)
      33710  NM_078754.4  NP_523478.1 
    worm
    (Caenorhabditis elegans)
    Secernentea eif-3.I1 eif-3.I 50.62(n)
    43.52(a)
      171809  NM_058587.4  NP_490988.2 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes TIF34(YMR146C)4
    TIF341
    eIF3i subunit of the core complex of translation initiation more4
    TIF341
    52.62(n)1
    46.15(a)1
      13(558524-557481)4
    8551771, 4  NP_013866.11, 4 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons AT2G462901 AT2G46290 53.15(n)
    47.37(a)
      819237  NM_130192.4  NP_182152.2 
    rice
    (Oryza sativa)
    Liliopsida Os.72312 Oryza sativa (japonica cultivar-group) cDNA cloneJ more 71.5(n)    AK122060.1 


    ENSEMBL Gene Tree for EIF3I (if available)
    TreeFam Gene Tree for EIF3I (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for EIF3I gene
    STRAP2  
    4 SIMAP similar genes for EIF3I using alignment to 2 protein entries:     EIF3I_HUMAN (see all proteins):
    EIF3S2    DAW1    FBXW7    SNRNP40

    Find genes that share paralogs with EIF3I           About GenesLikeMe


    2 Pseudogenes.org Pseudogenes for EIF3I
    PGOHUM00000232960 PGOHUM00000232974


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for EIF3I (see all 152)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1473431161,2
    C--32689986(+) ACTTCA/GTCATA 1 -- int10--------
    rs1129917821,2
    C--32690010(+) CTTCAG/TGGGAC 1 -- spa10--------
    rs1123074261,2
    C--32690078(+) ACAGGA/TAAGCT 1 -- spd11Minor allele frequency- T:0.00CSA 1
    rs1880485801,2
    --32690144(+) AAACAG/TGTCCT 1 -- int10--------
    rs12995471,2
    C,H--32690291(-) gtctcA/Caaaat 1 -- int19Minor allele frequency- C:0.00NA WA CSA EA 252
    rs1819137401,2
    --32690551(+) TGCCTC/TAGCCT 1 -- int10--------
    rs1863978491,2
    --32690578(+) TACAGA/GCATGC 1 -- int10--------
    rs1907971111,2
    --32690583(+) ACATGC/TGCCAT 1 -- int10--------
    rs609514281,2
    C,F--32690593(+) TCACAG/CCTGGC 1 -- int11Minor allele frequency- C:0.50WA 2
    rs1394318221,2
    --32690686(+) CACCTC/TGGCCT 1 -- int10--------

    HapMap Linkage Disequilibrium report for EIF3I (32687529 - 32697205 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for EIF3I:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv300CNV Insertion18451855

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing EIF3I
    DNA2.0 Custom Variant and Variant Library Synthesis for EIF3I

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 603911    OMIM disorders: --

    1 disease for EIF3I:    
    About MalaCards
    clonorchiasis

    1 disease from the University of Copenhagen DISEASES database for EIF3I:
    Clonorchiasis

    Find genes that share disorders with EIF3I           About GenesLikeMe


    Export disorders for EIF3I gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for EIF3I gene, integrated from 10 sources (see all 84):
    (articles sorted by number of sources associating them with EIF3I)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Conservation and diversity of eukaryotic translation initiation factor eIF3. (PubMed id 8995409)1, 2, 3, 9 Asano K.... Hershey J.W.B. (J. Biol. Chem. 1997)
    2. A WD-domain protein that is associated with and phosphorylated by the type II TGF-beta receptor. (PubMed id 7566156)1, 2, 3 Chen R.H.... Derynck R. (Nature 1995)
    3. Mass spectrometry reveals modularity and a complete subunit interaction map of the eukaryotic translation factor eIF3. (PubMed id 18599441)1, 2 Zhou M.... Robinson C.V. (Proc. Natl. Acad. Sci. U.S.A. 2008)
    4. Reconstitution reveals the functional core of mammalian eIF3. (PubMed id 17581632)1, 2 Masutani M.... Imataka H. (EMBO J. 2007)
    5. Structural characterization of the human eukaryotic initiation factor 3 protein complex by mass spectrometry. (PubMed id 17322308)1, 2 Damoc E.... Leary J.A. (Mol. Cell. Proteomics 2007)
    6. Immunoaffinity profiling of tyrosine phosphorylation in cancer cells. (PubMed id 15592455)1, 2 Rush J.... Comb M.J. (Nat. Biotechnol. 2005)
    7. The j-subunit of human translation initiation factor eIF3 is required for the stable binding of eIF3 and its subcomplexes to 40 S ribosomal subunits in vitro. (PubMed id 14688252)1, 2 Fraser C.S....Hershey J.W.B. (J. Biol. Chem. 2004)
    8. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    9. Characterization of eIF3k: a newly discovered subunit of mammalian translation initiation factor eIF3. (PubMed id 14519125)1, 2 Mayeur G.L.... Hershey J.W.B. (Eur. J. Biochem. 2003)
    10. Genomic structure and chromosomal location of the human TGFbeta-receptor interacting protein-1 (TRIP-1) gene to 1p34.1. (PubMed id 9599024)1, 9 Galli-Stauber C....Sorrentino V. (FEBS Lett. 1998)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 8668 HGNC: 3272 AceView: EIF3S2 Ensembl:ENSG00000084623 euGenes: HUgn8668
    ECgene: EIF3I Kegg: 8668 H-InvDB: EIF3I

    (According to HUGE)
    About This Section

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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for EIF3I Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for EIF3I gene:
    Search GeneIP for patents involving EIF3I

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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