Aliases for EIF3I Gene
External Ids for EIF3I Gene
Previous HGNC Symbols for EIF3I Gene
Previous GeneCards Identifiers for EIF3I Gene
GeneCards Summary for EIF3I Gene
EIF3I (Eukaryotic Translation Initiation Factor 3, Subunit I) is a Protein Coding gene. Diseases associated with EIF3I include clonorchiasis. Among its related pathways are p70S6K Signaling and Apoptotic Pathways in Synovial Fibroblasts. GO annotations related to this gene include translation initiation factor activity. An important paralog of this gene is STRAP.
UniProtKB/Swiss-Prot for EIF3I Gene
Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S preinitiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation