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Aliases for EIF3I Gene

Aliases for EIF3I Gene

  • Eukaryotic Translation Initiation Factor 3 Subunit I 2 3 5
  • Eukaryotic Translation Initiation Factor 3, Subunit 2 Beta, 36kDa 2 3
  • Eukaryotic Translation Initiation Factor 3 Subunit 2 3 4
  • TGF-Beta Receptor-Interacting Protein 1 3 4
  • EIF3S2 3 4
  • TRIP-1 3 4
  • TRIP1 3 4
  • Eukaryotic Translation Initiation Factor 3, Subunit 2 (Beta, 36kD) 3
  • Eukaryotic Translation Initiation Factor 3, Subunit I 2
  • TGFbeta Receptor-Interacting Protein 1 3
  • Predicted Protein Of HQ2242 3
  • EIF-3-Beta 4
  • EIF3-Beta 3
  • EIF3-P36 3
  • EIF3 P36 4
  • PRO2242 3
  • EIF3i 4

External Ids for EIF3I Gene

Previous HGNC Symbols for EIF3I Gene

  • EIF3S2

Previous GeneCards Identifiers for EIF3I Gene

  • GC01P032462
  • GC01P032687
  • GC01P030804

Summaries for EIF3I Gene

GeneCards Summary for EIF3I Gene

EIF3I (Eukaryotic Translation Initiation Factor 3 Subunit I) is a Protein Coding gene. Among its related pathways are Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S and Apoptotic Pathways in Synovial Fibroblasts. GO annotations related to this gene include translation initiation factor activity. An important paralog of this gene is STRAP.

UniProtKB/Swiss-Prot for EIF3I Gene

  • Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis (PubMed:17581632, PubMed:25849773, PubMed:27462815). The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation (PubMed:17581632). The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, including cell cycling, differentiation and apoptosis, and uses different modes of RNA stem-loop binding to exert either translational activation or repression (PubMed:25849773).

Gene Wiki entry for EIF3I Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for EIF3I Gene

Genomics for EIF3I Gene

Regulatory Elements for EIF3I Gene

Enhancers for EIF3I Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH01F031924 1.3 FANTOM5 ENCODE 51.9 -286.0 -286035 22.1 MLX CREB3L1 ZFP64 FEZF1 DMAP1 YBX1 YY1 SLC30A9 ZNF416 ZNF143 SNRNP40 ENSG00000229447 EIF3I TSSK3 MTMR9LP LOC105378626 KPNA6 ENSG00000224066 FAM167B KHDRBS1
GH01F032350 0.8 ENCODE 39.5 +130.9 130864 4.4 MLX CREB3L1 ZFP64 DMAP1 FEZF1 YY1 SLC30A9 ZNF143 ZNF548 ZNF263 EIF3I ENSG00000224066 LOC105378626 TSSK3 MTMR9LP KPNA6 DCDC2B IQCC FAM167B LOC105378629
GH01F032813 0.8 FANTOM5 ENCODE 39.4 +595.4 595375 7.3 CREB3L1 MLX ZFP64 FEZF1 DMAP1 YY1 SLC30A9 ZNF143 ZNF263 SP3 EIF3I MTMR9LP KPNA6 FNDC5 S100PBP TSSK3 FAM167B ENSG00000224066 YARS
GH01F033003 1.3 Ensembl ENCODE 33.8 +785.0 784990 7.0 HDGF PKNOX1 ARNT CREB3L1 ZFP64 SIN3A ARID4B ZNF2 YY1 ZNF143 EIF3I ENSG00000239670 MTMR9LP KPNA6 AZIN2 AK2 TSSK3 FAM167B FNDC5 ENSG00000224066
GH01F032141 1.1 Ensembl ENCODE 32.1 -79.1 -79147 2.2 TBP HDAC1 ZNF493 ZFP64 ZNF133 ARID4B SIN3A KLF7 ZNF362 ZNF680 SNRNP40 ENSG00000229447 TSSK3 EIF3I ENSG00000224066 DCDC2B KPNA6 IQCC LOC105378626 CCDC28B
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around EIF3I on UCSC Golden Path with GeneCards custom track

Promoters for EIF3I Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001518947 533 1601 PKNOX1 ATF1 CREB3L1 ARID4B SIN3A DMAP1 ETS1 YY1 GLIS2 ELK1

Genomic Location for EIF3I Gene

Chromosome:
1
Start:
32,221,867 bp from pter
End:
32,231,604 bp from pter
Size:
9,738 bases
Orientation:
Plus strand

Genomic View for EIF3I Gene

Genes around EIF3I on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
EIF3I Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for EIF3I Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for EIF3I Gene

Proteins for EIF3I Gene

  • Protein details for EIF3I Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q13347-EIF3I_HUMAN
    Recommended name:
    Eukaryotic translation initiation factor 3 subunit I
    Protein Accession:
    Q13347

    Protein attributes for EIF3I Gene

    Size:
    325 amino acids
    Molecular mass:
    36502 Da
    Quaternary structure:
    • Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is composed of 13 subunits: EIF3A, EIF3B, EIF3C, EIF3D, EIF3E, EIF3F, EIF3G, EIF3H, EIF3I, EIF3J, EIF3K, EIF3L and EIF3M. The eIF-3 complex appears to include 3 stable modules: module A is composed of EIF3A, EIF3B, EIF3G and EIF3I; module B is composed of EIF3F, EIF3H, and EIF3M; and module C is composed of EIF3C, EIF3D, EIF3E, EIF3K and EIF3L. EIF3C of module C binds EIF3B of module A and EIF3H of module B, thereby linking the three modules. EIF3J is a labile subunit that binds to the eIF-3 complex via EIF3B. The eIF-3 complex interacts with RPS6KB1 under conditions of nutrient depletion. Mitogenic stimulation leads to binding and activation of a complex composed of MTOR and RPTOR, leading to phosphorylation and release of RPS6KB1 and binding of EIF4B to eIF-3.

neXtProt entry for EIF3I Gene

Post-translational modifications for EIF3I Gene

  • Phosphorylated by TGF-beta type II receptor.
  • Ubiquitination at Lys 2, Lys 30, Lys 65, Lys 85, Lys 91, Lys 148, Lys 176, Lys 185, Lys 208, Lys 213, Lys 224, Lys 264, Lys 282, and Lys 298
  • Modification sites at PhosphoSitePlus

Other Protein References for EIF3I Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for EIF3I Gene

Domains & Families for EIF3I Gene

Graphical View of Domain Structure for InterPro Entry

Q13347

UniProtKB/Swiss-Prot:

EIF3I_HUMAN :
  • Belongs to the eIF-3 subunit I family.
  • Contains 7 WD repeats.
Family:
  • Belongs to the eIF-3 subunit I family.
Similarity:
  • Contains 7 WD repeats.
genes like me logo Genes that share domains with EIF3I: view

Function for EIF3I Gene

Molecular function for EIF3I Gene

UniProtKB/Swiss-Prot Function:
Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis (PubMed:17581632, PubMed:25849773, PubMed:27462815). The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation (PubMed:17581632). The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, including cell cycling, differentiation and apoptosis, and uses different modes of RNA stem-loop binding to exert either translational activation or repression (PubMed:25849773).

Gene Ontology (GO) - Molecular Function for EIF3I Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003743 contributes_to translation initiation factor activity IDA 25849773
GO:0005515 protein binding IPI 14688252
genes like me logo Genes that share ontologies with EIF3I: view
genes like me logo Genes that share phenotypes with EIF3I: view

Animal Model Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for EIF3I Gene

Localization for EIF3I Gene

Subcellular locations from UniProtKB/Swiss-Prot for EIF3I Gene

Cytoplasm.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for EIF3I Gene COMPARTMENTS Subcellular localization image for EIF3I gene
Compartment Confidence
cytosol 5
extracellular 5
nucleus 3

Gene Ontology (GO) - Cellular Components for EIF3I Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
GO:0005829 cytosol TAS --
GO:0005852 eukaryotic translation initiation factor 3 complex IDA 17322308
GO:0016282 eukaryotic 43S preinitiation complex IEA --
GO:0033290 eukaryotic 48S preinitiation complex IEA --
genes like me logo Genes that share ontologies with EIF3I: view

Pathways & Interactions for EIF3I Gene

genes like me logo Genes that share pathways with EIF3I: view

SIGNOR curated interactions for EIF3I Gene

Activates:

Gene Ontology (GO) - Biological Process for EIF3I Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006412 translation IEA --
GO:0006413 translational initiation TAS --
GO:0006446 regulation of translational initiation IEA --
genes like me logo Genes that share ontologies with EIF3I: view

Transcripts for EIF3I Gene

Unigene Clusters for EIF3I Gene

Eukaryotic translation initiation factor 3, subunit I:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for EIF3I Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3 ^ 4a · 4b ^ 5a · 5b · 5c ^ 6a · 6b ^ 7 ^ 8 ^ 9 ^ 10 ^ 11
SP1: - - - -
SP2: - - -
SP3: - -
SP4: - -
SP5: - - -
SP6: -

Relevant External Links for EIF3I Gene

GeneLoc Exon Structure for
EIF3I
ECgene alternative splicing isoforms for
EIF3I

Expression for EIF3I Gene

mRNA expression in normal human tissues for EIF3I Gene

Protein differential expression in normal tissues from HIPED for EIF3I Gene

This gene is overexpressed in Peripheral blood mononuclear cells (8.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for EIF3I Gene



Protein tissue co-expression partners for EIF3I Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of EIF3I Gene:

EIF3I

SOURCE GeneReport for Unigene cluster for EIF3I Gene:

Hs.530096
genes like me logo Genes that share expression patterns with EIF3I: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for EIF3I Gene

Orthologs for EIF3I Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for EIF3I Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia EIF3I 35
  • 100 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia EIF3I 35
  • 97 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia EIF3I 35
  • 96 (a)
OneToOne
cow
(Bos Taurus)
Mammalia EIF3I 34 35
  • 93.44 (n)
dog
(Canis familiaris)
Mammalia EIF3I 34 35
  • 92.72 (n)
rat
(Rattus norvegicus)
Mammalia Eif3i 34
  • 91.49 (n)
mouse
(Mus musculus)
Mammalia Eif3i 34 16 35
  • 91.28 (n)
chicken
(Gallus gallus)
Aves EIF3I 34 35
  • 83.59 (n)
lizard
(Anolis carolinensis)
Reptilia EIF3I 35
  • 92 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia eif3i 34
  • 78.46 (n)
Str.5958 34
zebrafish
(Danio rerio)
Actinopterygii eif3i 34 35
  • 75.49 (n)
Dr.895 34
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.10798 34
fruit fly
(Drosophila melanogaster)
Insecta Trip1 34 35
  • 61.52 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta EIF3I_ANOGA 34
  • 59.67 (n)
worm
(Caenorhabditis elegans)
Secernentea eif-3.I 34 35
  • 50.62 (n)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_ADR264C 34
  • 53.03 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes TIF34 34 35 37
  • 52.62 (n)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0F07403g 34
  • 52.1 (n)
thale cress
(Arabidopsis thaliana)
eudicotyledons AT2G46290 34
  • 53.15 (n)
soybean
(Glycine max)
eudicotyledons Gma.3948 34
Alicante grape
(Vitis vinifera)
eudicotyledons Vvi.282 34
rice
(Oryza sativa)
Liliopsida Os05g0256000 34
  • 54.49 (n)
Os.7231 34
barley
(Hordeum vulgare)
Liliopsida Hv.2368 34
wheat
(Triticum aestivum)
Liliopsida Ta.2846 34
bread mold
(Neurospora crassa)
Ascomycetes NCU03876 34
  • 57.03 (n)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes sum1 34
  • 52.94 (n)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.4745 34
Species where no ortholog for EIF3I was found in the sources mined by GeneCards:
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)

Evolution for EIF3I Gene

ENSEMBL:
Gene Tree for EIF3I (if available)
TreeFam:
Gene Tree for EIF3I (if available)

Paralogs for EIF3I Gene

Paralogs for EIF3I Gene

(4) SIMAP similar genes for EIF3I Gene using alignment to 2 proteins:

Pseudogenes.org Pseudogenes for EIF3I Gene

genes like me logo Genes that share paralogs with EIF3I: view

Variants for EIF3I Gene

Sequence variations from dbSNP and Humsavar for EIF3I Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs111386679 -- 32,220,461(+) CGTGA(A/G)TCACC intron-variant, upstream-variant-2KB
rs111388061 -- 32,225,614(+) TGGGC(A/G)CCTGT intron-variant
rs111825471 -- 32,231,976(+) TGAGG(A/G)GGAGG intron-variant, downstream-variant-500B
rs111871172 -- 32,228,662(+) CACAG(A/C)TCACC intron-variant
rs111982592 -- 32,226,322(+) ATTGG(A/C/T)GAGGG intron-variant, splice-donor-variant

Structural Variations from Database of Genomic Variants (DGV) for EIF3I Gene

Variant ID Type Subtype PubMed ID
nsv300 CNV insertion 18451855

Variation tolerance for EIF3I Gene

Residual Variation Intolerance Score: 20.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.39; 8.55% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for EIF3I Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
EIF3I

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for EIF3I Gene

Disorders for EIF3I Gene

Relevant External Links for EIF3I

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
EIF3I

No disorders were found for EIF3I Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for EIF3I Gene

Publications for EIF3I Gene

  1. Conservation and diversity of eukaryotic translation initiation factor eIF3. (PMID: 8995409) Asano K. … Hershey J.W.B. (J. Biol. Chem. 1997) 2 3 4 22 64
  2. A WD-domain protein that is associated with and phosphorylated by the type II TGF-beta receptor. (PMID: 7566156) Chen R.H. … Derynck R. (Nature 1995) 2 3 4 64
  3. eIF3 targets cell-proliferation messenger RNAs for translational activation or repression. (PMID: 25849773) Lee A.S. … Cate J.H. (Nature 2015) 3 4 64
  4. Higher TRIP-1 level explains diminished collagen contraction ability of fetal versus adult fibroblasts. (PMID: 19329541) Navarro A. … Ekekezie I.I. (Am. J. Physiol. Lung Cell Mol. Physiol. 2009) 3 22 64
  5. Mass spectrometry reveals modularity and a complete subunit interaction map of the eukaryotic translation factor eIF3. (PMID: 18599441) Zhou M. … Robinson C.V. (Proc. Natl. Acad. Sci. U.S.A. 2008) 3 4 64

Products for EIF3I Gene

Sources for EIF3I Gene

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