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Aliases for EIF3H Gene

Aliases for EIF3H Gene

  • Eukaryotic Translation Initiation Factor 3, Subunit H 2 3
  • EIF3S3 3 4 6
  • Eukaryotic Translation Initiation Factor 3, Subunit 3 Gamma, 40kDa 2 3
  • Eukaryotic Translation Initiation Factor 3 Subunit 3 3 4
  • EIF3 P40 Subunit 3 4
  • EIF-3-Gamma 3 4
  • Eukaryotic Translation Initiation Factor 3, Subunit 3 (Gamma, 40kD) 3
  • Eukaryotic Translation Initiation Factor 3, Subunit 2 (Beta, 36kD) 3
  • Eukaryotic Translation Initiation Factor 3 Subunit H 3
  • EIF3-Gamma 3
  • EIF3-P40 3
  • EIF3h 4

External Ids for EIF3H Gene

Previous Symbols for EIF3H Gene

  • EIF3S3

Summaries for EIF3H Gene

GeneCards Summary for EIF3H Gene

EIF3H (Eukaryotic Translation Initiation Factor 3, Subunit H) is a Protein Coding gene. Diseases associated with EIF3H include trichorhinophalangeal syndrome, type i. Among its related pathways are p70S6K Signaling and Apoptotic Pathways in Synovial Fibroblasts. GO annotations related to this gene include translation initiation factor activity.

UniProtKB/Swiss-Prot for EIF3H Gene

  • Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S preinitiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation

Gene Wiki entry for EIF3H Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for EIF3H Gene

Genomics for EIF3H Gene

Genomic Location for EIF3H Gene

Start:
116,642,130 bp from pter
End:
116,766,925 bp from pter
Size:
124,796 bases
Orientation:
Minus strand

Genomic View for EIF3H Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for EIF3H Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for EIF3H Gene

Regulatory Elements for EIF3H Gene

Proteins for EIF3H Gene

  • Protein details for EIF3H Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O15372-EIF3H_HUMAN
    Recommended name:
    Eukaryotic translation initiation factor 3 subunit H
    Protein Accession:
    O15372
    Secondary Accessions:

    Protein attributes for EIF3H Gene

    Size:
    352 amino acids
    Molecular mass:
    39930 Da
    Quaternary structure:
    • Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is composed of 13 subunits: EIF3A, EIF3B, EIF3C, EIF3D, EIF3E, EIF3F, EIF3G, EIF3H, EIF3I, EIF3J, EIF3K, EIF3L and EIF3M. The eIF-3 complex appears to include 3 stable modules: module A is composed of EIF3A, EIF3B, EIF3G and EIF3I; module B is composed of EIF3F, EIF3H, and EIF3M; and module C is composed of EIF3C, EIF3D, EIF3E, EIF3K and EIF3L. EIF3C of module C binds EIF3B of module A and EIF3H of module B, thereby linking the three modules. EIF3J is a labile subunit that binds to the eIF-3 complex via EIF3B. The eIF-3 complex interacts with RPS6KB1 under conditions of nutrient depletion. Mitogenic stimulation leads to binding and activation of a complex composed of MTOR and RPTOR, leading to phosphorylation and release of RPS6KB1 and binding of EIF4B to eIF-3. Interacts with RNF139; the interaction leads to protein translation inhibitions in a ubiquitination-dependent manner.

    Three dimensional structures from OCA and Proteopedia for EIF3H Gene

neXtProt entry for EIF3H Gene

Proteomics data for EIF3H Gene at MOPED

Post-translational modifications for EIF3H Gene

  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys5, Lys24, Lys227, Lys259, Lys303, Lys306, Lys331, and Lys340

Other Protein References for EIF3H Gene

No data available for DME Specific Peptides for EIF3H Gene

Domains for EIF3H Gene

Protein Domains for EIF3H Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for EIF3H Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

O15372

UniProtKB/Swiss-Prot:

EIF3H_HUMAN
Domain:
  • Contains 1 MPN (JAB/Mov34) domain.:
    • O15372
Family:
  • Belongs to the eIF-3 subunit H family.:
    • O15372
genes like me logo Genes that share domains with EIF3H: view

No data available for Gene Families for EIF3H Gene

Function for EIF3H Gene

Molecular function for EIF3H Gene

UniProtKB/Swiss-Prot Function: Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S preinitiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation

Gene Ontology (GO) - Molecular Function for EIF3H Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003743 contributes_to translation initiation factor activity IDA 17581632
GO:0005515 protein binding IPI 12812986
GO:0044822 poly(A) RNA binding IDA 22658674
genes like me logo Genes that share ontologies with EIF3H: view
genes like me logo Genes that share phenotypes with EIF3H: view

miRNA for EIF3H Gene

miRTarBase miRNAs that target EIF3H

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for EIF3H Gene

Localization for EIF3H Gene

Subcellular locations from UniProtKB/Swiss-Prot for EIF3H Gene

Cytoplasm.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for EIF3H Gene COMPARTMENTS Subcellular localization image for EIF3H gene
Compartment Confidence
cytosol 4
nucleus 2
endoplasmic reticulum 1
extracellular 1
mitochondrion 1

Gene Ontology (GO) - Cellular Components for EIF3H Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005829 cytosol TAS --
GO:0005852 eukaryotic translation initiation factor 3 complex IDA 17322308
GO:0016020 membrane IDA 19946888
GO:0016282 eukaryotic 43S preinitiation complex IEA --
GO:0033290 eukaryotic 48S preinitiation complex IEA --
genes like me logo Genes that share ontologies with EIF3H: view

Pathways for EIF3H Gene

genes like me logo Genes that share pathways with EIF3H: view

Pathways by source for EIF3H Gene

2 Qiagen pathways for EIF3H Gene
1 Cell Signaling Technology pathway for EIF3H Gene
1 BioSystems pathway for EIF3H Gene

Gene Ontology (GO) - Biological Process for EIF3H Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001731 formation of translation preinitiation complex IEA --
GO:0006412 translation TAS --
GO:0006413 translational initiation TAS --
GO:0006446 regulation of translational initiation TAS 9341143
GO:0010467 gene expression TAS --
genes like me logo Genes that share ontologies with EIF3H: view

Transcripts for EIF3H Gene

Unigene Clusters for EIF3H Gene

Eukaryotic translation initiation factor 3, subunit H:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for EIF3H Gene

ExUns: 1 ^ 2 ^ 3a · 3b ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8 ^ 9 ^ 10
SP1: - -
SP2: -

Relevant External Links for EIF3H Gene

GeneLoc Exon Structure for
EIF3H
ECgene alternative splicing isoforms for
EIF3H

Expression for EIF3H Gene

mRNA expression in normal human tissues for EIF3H Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for EIF3H Gene

SOURCE GeneReport for Unigene cluster for EIF3H Gene Hs.492599

genes like me logo Genes that share expressions with EIF3H: view

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for EIF3H Gene

Orthologs for EIF3H Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for EIF3H Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia EIF3H 35
  • 99.91 (n)
  • 100 (a)
EIF3H 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia EIF3H 35
  • 92.71 (n)
  • 98.01 (a)
EIF3H 36
  • 98 (a)
OneToOne
dog
(Canis familiaris)
Mammalia EIF3H 35
  • 93.18 (n)
  • 98.3 (a)
EIF3H 36
  • 93 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Eif3h 35
  • 89.49 (n)
  • 97.16 (a)
Eif3h 16
Eif3h 36
  • 97 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia EIF3H 36
  • 96 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia EIF3H 36
  • 86 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Eif3h 35
  • 89.77 (n)
  • 97.73 (a)
chicken
(Gallus gallus)
Aves EIF3H 35
  • 82.61 (n)
  • 93.79 (a)
EIF3H 36
  • 91 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia EIF3H 36
  • 92 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.7704 35
tropical clawed frog
(Silurana tropicalis)
Amphibia eif3h 35
  • 74.53 (n)
  • 86.16 (a)
MGC75580 35
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.8437 35
zebrafish
(Danio rerio)
Actinopterygii eif3hb 35
  • 75.84 (n)
  • 86.71 (a)
eif3hb 36
  • 82 (a)
OneToOne
wufj02c04 35
African malaria mosquito
(Anopheles gambiae)
Insecta EIF3H_ANOGA 35
  • 56.98 (n)
  • 50.16 (a)
fruit fly
(Drosophila melanogaster)
Insecta eIF-3p40 35
  • 53.97 (n)
  • 46.67 (a)
eIF-3p40 36
  • 44 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea eif-3.H 35
  • 51.38 (n)
  • 42.36 (a)
eif-3.H 36
  • 36 (a)
OneToOne
thale cress
(Arabidopsis thaliana)
eudicotyledons TIF3H1 35
  • 52.26 (n)
  • 42.9 (a)
rice
(Oryza sativa)
Liliopsida Os04g0376500 35
  • 51.91 (n)
  • 43.31 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.2326 36
  • 54 (a)
OneToOne
Species with no ortholog for EIF3H:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for EIF3H Gene

ENSEMBL:
Gene Tree for EIF3H (if available)
TreeFam:
Gene Tree for EIF3H (if available)

Paralogs for EIF3H Gene

Selected SIMAP similar genes for EIF3H Gene using alignment to 8 proteins:

genes like me logo Genes that share paralogs with EIF3H: view

No data available for Paralogs for EIF3H Gene

Variants for EIF3H Gene

Sequence variations from dbSNP and Humsavar for EIF3H Gene

SNP ID Clin Chr 08 pos Sequence Context AA Info Type MAF
rs2366 -- 116,687,639(+) TAGGA(G/T)TTTAA intron-variant
rs10054 -- 116,644,942(-) CTCTT(C/G)GAAGA utr-variant-3-prime
rs1317271 -- 116,670,429(-) TGGAG(A/T)TTTCT intron-variant
rs1343663 -- 116,698,905(+) CACTT(C/T)GGGAG intron-variant
rs1347626 -- 116,644,542(+) GTACA(C/T)GAAGC downstream-variant-500B

Structural Variations from Database of Genomic Variants (DGV) for EIF3H Gene

Variant ID Type Subtype PubMed ID
esv1006976 CNV Insertion 20482838
nsv821264 CNV Duplication 20802225
nsv824723 CNV Loss 20364138

Relevant External Links for EIF3H Gene

HapMap Linkage Disequilibrium report
EIF3H
Human Gene Mutation Database (HGMD)
EIF3H

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for EIF3H Gene

Disorders for EIF3H Gene

(1) University of Copenhagen DISEASES for EIF3H Gene

(5) Novoseek inferred disease relationships for EIF3H Gene

Disease -log(P) Hits PubMed IDs
prostate carcinoma 57.6 4
prostate cancer 51.5 8
breast cancer 33.4 2
cancer 1.82 1
tumors 0 3

Relevant External Links for EIF3H

Genetic Association Database (GAD)
EIF3H
Human Genome Epidemiology (HuGE) Navigator
EIF3H
genes like me logo Genes that share disorders with EIF3H: view

No data available for UniProtKB/Swiss-Prot for EIF3H Gene

Publications for EIF3H Gene

  1. Structure of cDNAs encoding human eukaryotic initiation factor 3 subunits. Possible roles in RNA binding and macromolecular assembly. (PMID: 9341143) Asano K. … Hershey J.W.B. (J. Biol. Chem. 1997) 2 3 4
  2. Amplification of EIF3S3 gene is associated with advanced stage in prostate cancer. (PMID: 11733359) SaramAoki O. … Visakorpi T. (Am. J. Pathol. 2001) 3 23
  3. Expression and copy number analysis of TRPS1, EIF3S3 and MYC genes in breast and prostate cancer. (PMID: 14997205) Savinainen K.J. … Visakorpi T. (Br. J. Cancer 2004) 3 23
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  5. mTOR and S6K1 mediate assembly of the translation preinitiation complex through dynamic protein interchange and ordered phosphorylation events. (PMID: 16286006) Holz M.K. … Blenis J. (Cell 2005) 3 4

Products for EIF3H Gene

  • Addgene plasmids for EIF3H

Sources for EIF3H Gene

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