Free for academic non-profit institutions. Other users need a Commercial license

Aliases for EIF3H Gene

Aliases for EIF3H Gene

  • Eukaryotic Translation Initiation Factor 3 Subunit H 2 3 5
  • Eukaryotic Translation Initiation Factor 3, Subunit 3 Gamma, 40kDa 2 3
  • Eukaryotic Translation Initiation Factor 3 Subunit 3 3 4
  • EIF3 P40 Subunit 3 4
  • EIF-3-Gamma 3 4
  • EIF3S3 3 4
  • Eukaryotic Translation Initiation Factor 3, Subunit 3 (Gamma, 40kD) 3
  • Eukaryotic Translation Initiation Factor 3, Subunit 2 (Beta, 36kD) 3
  • Eukaryotic Translation Initiation Factor 3, Subunit H 2
  • EIF3-Gamma 3
  • EIF3-P40 3
  • EIF3h 4

External Ids for EIF3H Gene

Previous HGNC Symbols for EIF3H Gene

  • EIF3S3

Previous GeneCards Identifiers for EIF3H Gene

  • GC08M117727
  • GC08M112983
  • GC08M117654

Summaries for EIF3H Gene

GeneCards Summary for EIF3H Gene

EIF3H (Eukaryotic Translation Initiation Factor 3 Subunit H) is a Protein Coding gene. Diseases associated with EIF3H include Trichorhinophalangeal Syndrome, Type I and Trichorhinophalangeal Syndrome, Type Ii. Among its related pathways are Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S and Apoptotic Pathways in Synovial Fibroblasts. GO annotations related to this gene include poly(A) RNA binding and translation initiation factor activity.

UniProtKB/Swiss-Prot for EIF3H Gene

  • Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis (PubMed:17581632, PubMed:25849773, PubMed:27462815). The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation (PubMed:17581632). The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, including cell cycling, differentiation and apoptosis, and uses different modes of RNA stem-loop binding to exert either translational activation or repression (PubMed:25849773).

Gene Wiki entry for EIF3H Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for EIF3H Gene

Genomics for EIF3H Gene

Regulatory Elements for EIF3H Gene

Enhancers for EIF3H Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH08F116656 2.2 Ensembl ENCODE 6.4 +108.6 108610 2.8 PKNOX1 ATF1 MLX ARID4B DMAP1 YY1 FOS SP5 PPARG KAT8 EIF3H LOC105375713 UTP23
GH08F117519 1.1 ENCODE 12 -754.1 -754055 2.4 PKNOX1 WRNIP1 ARID4B SIN3A DMAP1 ZNF2 FOS DEK CEBPZ SP3 UTP23 EIF3H EXT1 MED30 RPS10P16
GH08F116693 0.6 Ensembl 6.5 +73.1 73125 0.4 CTCF NR2F1 IKZF1 ZNF501 RAD21 EIF3H LOC105375713 UTP23
GH08F116631 0.4 ENCODE 5 +135.2 135157 1.1 FOXP2 EIF3H LOC105375713 LOC105375712
GH08F116765 1.1 ENCODE 0.8 +0.1 84 2.9 PKNOX1 CREB3L1 MLX WRNIP1 ARID4B SIN3A DMAP1 YY1 ZNF143 ZNF207 UTP23 RAD21 EIF3H
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around EIF3H on UCSC Golden Path with GeneCards custom track

Promoters for EIF3H Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001399547 324 2400 PKNOX1 CREB3L1 MLX WRNIP1 ARID4B SIN3A DMAP1 YY1 ZNF143 ZNF207

Genomic Location for EIF3H Gene

Chromosome:
8
Start:
116,642,130 bp from pter
End:
116,766,925 bp from pter
Size:
124,796 bases
Orientation:
Minus strand

Genomic View for EIF3H Gene

Genes around EIF3H on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
EIF3H Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for EIF3H Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for EIF3H Gene

Proteins for EIF3H Gene

  • Protein details for EIF3H Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O15372-EIF3H_HUMAN
    Recommended name:
    Eukaryotic translation initiation factor 3 subunit H
    Protein Accession:
    O15372

    Protein attributes for EIF3H Gene

    Size:
    352 amino acids
    Molecular mass:
    39930 Da
    Quaternary structure:
    • Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is composed of 13 subunits: EIF3A, EIF3B, EIF3C, EIF3D, EIF3E, EIF3F, EIF3G, EIF3H, EIF3I, EIF3J, EIF3K, EIF3L and EIF3M. The eIF-3 complex appears to include 3 stable modules: module A is composed of EIF3A, EIF3B, EIF3G and EIF3I; module B is composed of EIF3F, EIF3H, and EIF3M; and module C is composed of EIF3C, EIF3D, EIF3E, EIF3K and EIF3L. EIF3C of module C binds EIF3B of module A and EIF3H of module B, thereby linking the three modules. EIF3J is a labile subunit that binds to the eIF-3 complex via EIF3B. The eIF-3 complex interacts with RPS6KB1 under conditions of nutrient depletion. Mitogenic stimulation leads to binding and activation of a complex composed of MTOR and RPTOR, leading to phosphorylation and release of RPS6KB1 and binding of EIF4B to eIF-3. Interacts with RNF139; the interaction leads to protein translation inhibitions in a ubiquitination-dependent manner.

    Three dimensional structures from OCA and Proteopedia for EIF3H Gene

neXtProt entry for EIF3H Gene

Post-translational modifications for EIF3H Gene

  • Ubiquitination at Lys 5, Lys 24, Lys 227, Lys 259, Lys 303, Lys 306, Lys 331, and Lys 340
  • Modification sites at PhosphoSitePlus

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for EIF3H (eIF3S3)

No data available for DME Specific Peptides for EIF3H Gene

Domains & Families for EIF3H Gene

Gene Families for EIF3H Gene

Protein Domains for EIF3H Gene

InterPro:
Blocks:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

O15372

UniProtKB/Swiss-Prot:

EIF3H_HUMAN :
  • Contains 1 MPN (JAB/Mov34) domain.
  • Belongs to the eIF-3 subunit H family.
Domain:
  • Contains 1 MPN (JAB/Mov34) domain.
Family:
  • Belongs to the eIF-3 subunit H family.
genes like me logo Genes that share domains with EIF3H: view

Function for EIF3H Gene

Molecular function for EIF3H Gene

UniProtKB/Swiss-Prot Function:
Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis (PubMed:17581632, PubMed:25849773, PubMed:27462815). The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation (PubMed:17581632). The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, including cell cycling, differentiation and apoptosis, and uses different modes of RNA stem-loop binding to exert either translational activation or repression (PubMed:25849773).

Gene Ontology (GO) - Molecular Function for EIF3H Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003743 contributes_to translation initiation factor activity IEA,IDA 17581632
GO:0005515 protein binding IPI 12812986
GO:0044822 poly(A) RNA binding IDA 22658674
genes like me logo Genes that share ontologies with EIF3H: view
genes like me logo Genes that share phenotypes with EIF3H: view

Animal Models for EIF3H Gene

MGI Knock Outs for EIF3H:

Animal Model Products

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for EIF3H

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for EIF3H Gene

Localization for EIF3H Gene

Subcellular locations from UniProtKB/Swiss-Prot for EIF3H Gene

Cytoplasm.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for EIF3H gene
Compartment Confidence
extracellular 5
cytosol 5
nucleus 2
mitochondrion 1
endoplasmic reticulum 1

Gene Ontology (GO) - Cellular Components for EIF3H Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
GO:0005829 cytosol TAS --
GO:0005852 eukaryotic translation initiation factor 3 complex IEA,IDA 17322308
GO:0016020 membrane IDA 19946888
GO:0016282 eukaryotic 43S preinitiation complex IEA --
genes like me logo Genes that share ontologies with EIF3H: view

Pathways & Interactions for EIF3H Gene

genes like me logo Genes that share pathways with EIF3H: view

Gene Ontology (GO) - Biological Process for EIF3H Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006412 translation IEA --
GO:0006413 translational initiation IEA,TAS --
GO:0006446 regulation of translational initiation TAS 9341143
genes like me logo Genes that share ontologies with EIF3H: view

No data available for SIGNOR curated interactions for EIF3H Gene

Transcripts for EIF3H Gene

Unigene Clusters for EIF3H Gene

Eukaryotic translation initiation factor 3, subunit H:
Representative Sequences:

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for EIF3H

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for EIF3H Gene

ExUns: 1 ^ 2 ^ 3a · 3b ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8 ^ 9 ^ 10
SP1: - -
SP2: -

Relevant External Links for EIF3H Gene

GeneLoc Exon Structure for
EIF3H
ECgene alternative splicing isoforms for
EIF3H

Expression for EIF3H Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for EIF3H Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for EIF3H Gene

This gene is overexpressed in Peripheral blood mononuclear cells (10.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for EIF3H Gene



Protein tissue co-expression partners for EIF3H Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of EIF3H Gene:

EIF3H

SOURCE GeneReport for Unigene cluster for EIF3H Gene:

Hs.492599
genes like me logo Genes that share expression patterns with EIF3H: view

Primer Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for EIF3H Gene

Orthologs for EIF3H Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for EIF3H Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia EIF3H 34 35
  • 99.91 (n)
oppossum
(Monodelphis domestica)
Mammalia EIF3H 35
  • 96 (a)
OneToOne
dog
(Canis familiaris)
Mammalia EIF3H 34 35
  • 93.18 (n)
cow
(Bos Taurus)
Mammalia EIF3H 34 35
  • 92.71 (n)
rat
(Rattus norvegicus)
Mammalia Eif3h 34
  • 89.77 (n)
mouse
(Mus musculus)
Mammalia Eif3h 34 16 35
  • 89.49 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia EIF3H 35
  • 86 (a)
OneToOne
chicken
(Gallus gallus)
Aves EIF3H 34 35
  • 82.61 (n)
lizard
(Anolis carolinensis)
Reptilia EIF3H 35
  • 92 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia eif3h 34
  • 74.53 (n)
MGC75580 34
African clawed frog
(Xenopus laevis)
Amphibia Xl.7704 34
zebrafish
(Danio rerio)
Actinopterygii eif3hb 34 35
  • 75.84 (n)
wufj02c04 34
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.8437 34
African malaria mosquito
(Anopheles gambiae)
Insecta EIF3H_ANOGA 34
  • 56.98 (n)
fruit fly
(Drosophila melanogaster)
Insecta eIF-3p40 34 35
  • 53.97 (n)
worm
(Caenorhabditis elegans)
Secernentea eif-3.H 34 35
  • 51.38 (n)
thale cress
(Arabidopsis thaliana)
eudicotyledons TIF3H1 34
  • 52.26 (n)
rice
(Oryza sativa)
Liliopsida Os04g0376500 34
  • 51.91 (n)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.2326 35
  • 54 (a)
OneToOne
Species where no ortholog for EIF3H was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for EIF3H Gene

ENSEMBL:
Gene Tree for EIF3H (if available)
TreeFam:
Gene Tree for EIF3H (if available)

Paralogs for EIF3H Gene

(1) SIMAP similar genes for EIF3H Gene using alignment to 8 proteins:

genes like me logo Genes that share paralogs with EIF3H: view

No data available for Paralogs for EIF3H Gene

Variants for EIF3H Gene

Sequence variations from dbSNP and Humsavar for EIF3H Gene

SNP ID Clin Chr 08 pos Sequence Context AA Info Type
rs10054 -- 116,644,942(-) CTCTT(C/G)GAAGA utr-variant-3-prime
rs10085939 -- 116,671,914(+) CTGAA(C/T)TGCAA intron-variant
rs10085941 -- 116,739,478(+) acccc(A/G)tctct intron-variant
rs10086419 -- 116,732,532(+) GCTTT(C/T)TGATG intron-variant
rs10088177 -- 116,744,718(+) GTACC(A/G)TAAAT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for EIF3H Gene

Variant ID Type Subtype PubMed ID
nsv981975 CNV duplication 23825009
nsv824723 CNV loss 20364138
nsv821264 CNV duplication 20802225
nsv480443 CNV novel sequence insertion 20440878
esv3443500 CNV duplication 20981092
esv1006976 CNV insertion 20482838

Variation tolerance for EIF3H Gene

Residual Variation Intolerance Score: 23% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.68; 14.53% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for EIF3H Gene

Human Gene Mutation Database (HGMD)
EIF3H
SNPedia medical, phenotypic, and genealogical associations of SNPs for
EIF3H

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for EIF3H Gene

Disorders for EIF3H Gene

MalaCards: The human disease database

(3) MalaCards diseases for EIF3H Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
trichorhinophalangeal syndrome, type i
  • trichorhinophalangeal syndrome, type iii
trichorhinophalangeal syndrome, type ii
  • trichorhinophalangeal syndrome type ii
prostate cancer
  • prostate cancer, hereditary, 5
- elite association - COSMIC cancer census association via MalaCards
Search EIF3H in MalaCards View complete list of genes associated with diseases

Relevant External Links for EIF3H

Genetic Association Database (GAD)
EIF3H
Human Genome Epidemiology (HuGE) Navigator
EIF3H
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
EIF3H
genes like me logo Genes that share disorders with EIF3H: view

No data available for UniProtKB/Swiss-Prot and Genatlas for EIF3H Gene

Publications for EIF3H Gene

  1. Structure of cDNAs encoding human eukaryotic initiation factor 3 subunits. Possible roles in RNA binding and macromolecular assembly. (PMID: 9341143) Asano K. … Hershey J.W.B. (J. Biol. Chem. 1997) 2 3 4 64
  2. eIF3 targets cell-proliferation messenger RNAs for translational activation or repression. (PMID: 25849773) Lee A.S. … Cate J.H. (Nature 2015) 3 4 64
  3. The utility and predictive value of combinations of low penetrance genes for screening and risk prediction of colorectal cancer. (PMID: 20437058) Hawken S.J. … Little J. (Hum. Genet. 2010) 3 46 64
  4. Genetic heterogeneity in colorectal cancer associations between African and European americans. (PMID: 20659471) Kupfer S.S. … Ellis N.A. (Gastroenterology 2010) 3 46 64
  5. MYC and EIF3H Coamplification significantly improve response and survival of non-small cell lung cancer patients (NSCLC) treated with gefitinib. (PMID: 19204574) Cappuzzo F. … Gemmill R. (J Thorac Oncol 2009) 3 46 64

Products for EIF3H Gene

Sources for EIF3H Gene

Content
Loading form....