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Aliases for EIF3H Gene

Aliases for EIF3H Gene

  • Eukaryotic Translation Initiation Factor 3 Subunit H 2 3 5
  • Eukaryotic Translation Initiation Factor 3, Subunit 3 Gamma, 40kDa 2 3
  • Eukaryotic Translation Initiation Factor 3 Subunit 3 3 4
  • EIF3 P40 Subunit 3 4
  • EIF-3-Gamma 3 4
  • EIF3S3 3 4
  • Eukaryotic Translation Initiation Factor 3, Subunit 3 (Gamma, 40kD) 3
  • Eukaryotic Translation Initiation Factor 3, Subunit 2 (Beta, 36kD) 3
  • Eukaryotic Translation Initiation Factor 3, Subunit H 2
  • EIF3-Gamma 3
  • EIF3-P40 3
  • EIF3h 4

External Ids for EIF3H Gene

Previous HGNC Symbols for EIF3H Gene

  • EIF3S3

Previous GeneCards Identifiers for EIF3H Gene

  • GC08M117727
  • GC08M112983
  • GC08M117654

Summaries for EIF3H Gene

GeneCards Summary for EIF3H Gene

EIF3H (Eukaryotic Translation Initiation Factor 3 Subunit H) is a Protein Coding gene. Diseases associated with EIF3H include Trichorhinophalangeal Syndrome, Type I and Trichorhinophalangeal Syndrome, Type Ii. Among its related pathways are Viral mRNA Translation and Translational Control. GO annotations related to this gene include poly(A) RNA binding and translation initiation factor activity.

UniProtKB/Swiss-Prot for EIF3H Gene

  • Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis (PubMed:17581632, PubMed:25849773, PubMed:27462815). The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation (PubMed:17581632). The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, including cell cycling, differentiation and apoptosis, and uses different modes of RNA stem-loop binding to exert either translational activation or repression (PubMed:25849773).

Gene Wiki entry for EIF3H Gene

Additional gene information for EIF3H Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for EIF3H Gene

Genomics for EIF3H Gene

Regulatory Elements for EIF3H Gene

Enhancers for EIF3H Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH08H116765 1.1 ENCODE 12.7 +0.1 84 2 PKNOX1 MLX ARNT ARID4B SIN3A DMAP1 YY1 ZNF766 ZNF207 ZNF143 UTP23 EIF3H RAD21
GH08H117519 1.1 ENCODE 12 -754.1 -754055 2 PKNOX1 FOXA2 ARID4B SIN3A DMAP1 ZNF2 ZBTB7B ZNF143 FOS DEK UTP23 EIF3H EXT1 MED30 RPS10P16
GH08H116656 2 Ensembl ENCODE 6.4 +108.6 108610 2 CTCF PKNOX1 CEBPG RAD21 IRF9 GATA3 RCOR1 PRDM10 ZNF362 MAZ EIF3H LOC105375713 UTP23
GH08H115987 0.7 ENCODE 11.7 +779.2 779153 1 CTBP1 GATA3 FOS TCF7L2 SMARCE1 ZNF687 DPF2 ELF1 FOXA1 ZNF217 EIF3H UTP23 RNA5SP276 TRPS1
GH08H116631 0.4 ENCODE 5 +135.2 135157 1 ZBTB40 EIF3H LOC105375713 LOC105375712
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around EIF3H on UCSC Golden Path with GeneCards custom track

Promoters for EIF3H Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000229070 325 2001 PKNOX1 MLX ARNT ARID4B SIN3A DMAP1 YY1 ZNF766 ZNF207 ZNF143

Genomic Location for EIF3H Gene

Chromosome:
8
Start:
116,642,130 bp from pter
End:
116,766,925 bp from pter
Size:
124,796 bases
Orientation:
Minus strand

Genomic View for EIF3H Gene

Genes around EIF3H on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
EIF3H Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for EIF3H Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for EIF3H Gene

Proteins for EIF3H Gene

  • Protein details for EIF3H Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O15372-EIF3H_HUMAN
    Recommended name:
    Eukaryotic translation initiation factor 3 subunit H
    Protein Accession:
    O15372

    Protein attributes for EIF3H Gene

    Size:
    352 amino acids
    Molecular mass:
    39930 Da
    Quaternary structure:
    • Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is composed of 13 subunits: EIF3A, EIF3B, EIF3C, EIF3D, EIF3E, EIF3F, EIF3G, EIF3H, EIF3I, EIF3J, EIF3K, EIF3L and EIF3M. The eIF-3 complex appears to include 3 stable modules: module A is composed of EIF3A, EIF3B, EIF3G and EIF3I; module B is composed of EIF3F, EIF3H, and EIF3M; and module C is composed of EIF3C, EIF3D, EIF3E, EIF3K and EIF3L. EIF3C of module C binds EIF3B of module A and EIF3H of module B, thereby linking the three modules. EIF3J is a labile subunit that binds to the eIF-3 complex via EIF3B. The eIF-3 complex interacts with RPS6KB1 under conditions of nutrient depletion. Mitogenic stimulation leads to binding and activation of a complex composed of MTOR and RPTOR, leading to phosphorylation and release of RPS6KB1 and binding of EIF4B to eIF-3. Interacts with RNF139; the interaction leads to protein translation inhibitions in a ubiquitination-dependent manner.

    Three dimensional structures from OCA and Proteopedia for EIF3H Gene

neXtProt entry for EIF3H Gene

Post-translational modifications for EIF3H Gene

  • Ubiquitination at isoforms=5, isoforms=24, posLast=227227, posLast=259259, isoforms=303, isoforms=306, posLast=331331, and isoforms=340
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for EIF3H Gene

Domains & Families for EIF3H Gene

Gene Families for EIF3H Gene

HGNC:
Human Protein Atlas (HPA):
  • Cancer-related genes
  • Predicted intracellular proteins

Protein Domains for EIF3H Gene

InterPro:
Blocks:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

O15372

UniProtKB/Swiss-Prot:

EIF3H_HUMAN :
  • Belongs to the eIF-3 subunit H family.
Family:
  • Belongs to the eIF-3 subunit H family.
genes like me logo Genes that share domains with EIF3H: view

Function for EIF3H Gene

Molecular function for EIF3H Gene

UniProtKB/Swiss-Prot Function:
Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis (PubMed:17581632, PubMed:25849773, PubMed:27462815). The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation (PubMed:17581632). The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, including cell cycling, differentiation and apoptosis, and uses different modes of RNA stem-loop binding to exert either translational activation or repression (PubMed:25849773).

Phenotypes From GWAS Catalog for EIF3H Gene

Gene Ontology (GO) - Molecular Function for EIF3H Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003723 RNA binding IDA 22658674
GO:0003743 contributes_to translation initiation factor activity IEA,IDA 17581632
GO:0005515 protein binding IPI 12812986
genes like me logo Genes that share ontologies with EIF3H: view
genes like me logo Genes that share phenotypes with EIF3H: view

Animal Models for EIF3H Gene

MGI Knock Outs for EIF3H:

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for EIF3H
  • Applied Biological Materials Clones for EIF3H
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for EIF3H Gene

Localization for EIF3H Gene

Subcellular locations from UniProtKB/Swiss-Prot for EIF3H Gene

Cytoplasm.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for EIF3H gene
Compartment Confidence
extracellular 5
cytosol 5
nucleus 2
mitochondrion 1
endoplasmic reticulum 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for EIF3H Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
GO:0005829 cytosol TAS --
GO:0005852 eukaryotic translation initiation factor 3 complex IEA,IDA 17322308
GO:0016020 membrane IDA 19946888
GO:0016282 eukaryotic 43S preinitiation complex IEA --
genes like me logo Genes that share ontologies with EIF3H: view

Pathways & Interactions for EIF3H Gene

genes like me logo Genes that share pathways with EIF3H: view

Gene Ontology (GO) - Biological Process for EIF3H Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006412 translation IEA --
GO:0006413 translational initiation IEA,TAS --
GO:0006446 regulation of translational initiation TAS 9341143
genes like me logo Genes that share ontologies with EIF3H: view

No data available for SIGNOR curated interactions for EIF3H Gene

Drugs & Compounds for EIF3H Gene

No Compound Related Data Available

Transcripts for EIF3H Gene

Unigene Clusters for EIF3H Gene

Eukaryotic translation initiation factor 3, subunit H:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for EIF3H
  • Applied Biological Materials Clones for EIF3H
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for EIF3H Gene

ExUns: 1 ^ 2 ^ 3a · 3b ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8 ^ 9 ^ 10
SP1: - -
SP2: -

Relevant External Links for EIF3H Gene

GeneLoc Exon Structure for
EIF3H
ECgene alternative splicing isoforms for
EIF3H

Expression for EIF3H Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for EIF3H Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for EIF3H Gene

This gene is overexpressed in Peripheral blood mononuclear cells (10.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for EIF3H Gene



Protein tissue co-expression partners for EIF3H Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of EIF3H Gene:

EIF3H

SOURCE GeneReport for Unigene cluster for EIF3H Gene:

Hs.492599

Evidence on tissue expression from TISSUES for EIF3H Gene

  • Lung(4.7)
  • Liver(4.6)
  • Intestine(4.4)
  • Nervous system(4.4)
  • Skin(3.6)
  • Eye(3.5)
  • Pancreas(3)
  • Lymph node(2.4)
  • Thyroid gland(2.4)
  • Gall bladder(2.3)
  • Muscle(2.3)
  • Bone marrow(2.2)
  • Heart(2.2)
  • Spleen(2.2)
  • Kidney(2.1)
genes like me logo Genes that share expression patterns with EIF3H: view

Primer Products

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for EIF3H Gene

Orthologs for EIF3H Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for EIF3H Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia EIF3H 33 34
  • 99.91 (n)
oppossum
(Monodelphis domestica)
Mammalia EIF3H 34
  • 96 (a)
OneToOne
dog
(Canis familiaris)
Mammalia EIF3H 33 34
  • 93.18 (n)
cow
(Bos Taurus)
Mammalia EIF3H 33 34
  • 92.71 (n)
rat
(Rattus norvegicus)
Mammalia Eif3h 33
  • 89.77 (n)
mouse
(Mus musculus)
Mammalia Eif3h 16 34 33
  • 89.49 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia EIF3H 34
  • 86 (a)
OneToOne
chicken
(Gallus gallus)
Aves EIF3H 34 33
  • 82.61 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia EIF3H 34
  • 92 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia eif3h 33
  • 74.53 (n)
MGC75580 33
African clawed frog
(Xenopus laevis)
Amphibia Xl.7704 33
zebrafish
(Danio rerio)
Actinopterygii eif3hb 33 34
  • 75.84 (n)
wufj02c04 33
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.8437 33
African malaria mosquito
(Anopheles gambiae)
Insecta EIF3H_ANOGA 33
  • 56.98 (n)
fruit fly
(Drosophila melanogaster)
Insecta eIF-3p40 33 34
  • 53.97 (n)
worm
(Caenorhabditis elegans)
Secernentea eif-3.H 33 34
  • 51.38 (n)
thale cress
(Arabidopsis thaliana)
eudicotyledons TIF3H1 33
  • 52.26 (n)
rice
(Oryza sativa)
Liliopsida Os04g0376500 33
  • 51.91 (n)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.2326 34
  • 54 (a)
OneToOne
Species where no ortholog for EIF3H was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for EIF3H Gene

ENSEMBL:
Gene Tree for EIF3H (if available)
TreeFam:
Gene Tree for EIF3H (if available)

Paralogs for EIF3H Gene

(1) SIMAP similar genes for EIF3H Gene using alignment to 8 proteins:

genes like me logo Genes that share paralogs with EIF3H: view

No data available for Paralogs for EIF3H Gene

Variants for EIF3H Gene

Sequence variations from dbSNP and Humsavar for EIF3H Gene

SNP ID Clin Chr 08 pos Sequence Context AA Info Type
rs1000024936 -- 116,712,258(+) TCTCC(A/G)TAAGG intron-variant
rs1000040446 -- 116,653,068(+) TGACA(C/G)TAGGG intron-variant
rs1000049573 -- 116,659,050(+) CAAGC(C/T)GTTTT intron-variant
rs1000088817 -- 116,730,431(+) GAAAC(C/T)ATCCT intron-variant
rs1000119913 -- 116,730,643(+) GATTC(A/G)AAGTA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for EIF3H Gene

Variant ID Type Subtype PubMed ID
esv1006976 CNV insertion 20482838
esv3443500 CNV duplication 20981092
nsv480443 CNV novel sequence insertion 20440878
nsv821264 CNV duplication 20802225
nsv824723 CNV loss 20364138
nsv981975 CNV duplication 23825009

Variation tolerance for EIF3H Gene

Residual Variation Intolerance Score: 23% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.68; 14.53% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for EIF3H Gene

Human Gene Mutation Database (HGMD)
EIF3H
SNPedia medical, phenotypic, and genealogical associations of SNPs for
EIF3H

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for EIF3H Gene

Disorders for EIF3H Gene

MalaCards: The human disease database

(3) MalaCards diseases for EIF3H Gene - From: HGMD, DISEASES, and Novoseek

Disorder Aliases PubMed IDs
trichorhinophalangeal syndrome, type i
  • trichorhinophalangeal syndrome type i
trichorhinophalangeal syndrome, type ii
  • trichorhinophalangeal syndrome type ii
prostate cancer
  • prostate cancer, hereditary, 5
- elite association - COSMIC cancer census association via MalaCards
Search EIF3H in MalaCards View complete list of genes associated with diseases

Relevant External Links for EIF3H

Genetic Association Database (GAD)
EIF3H
Human Genome Epidemiology (HuGE) Navigator
EIF3H
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
EIF3H
genes like me logo Genes that share disorders with EIF3H: view

No data available for UniProtKB/Swiss-Prot and Genatlas for EIF3H Gene

Publications for EIF3H Gene

  1. Structure of cDNAs encoding human eukaryotic initiation factor 3 subunits. Possible roles in RNA binding and macromolecular assembly. (PMID: 9341143) Asano K … Hershey JW (The Journal of biological chemistry 1997) 2 3 4 60
  2. eIF3 targets cell-proliferation messenger RNAs for translational activation or repression. (PMID: 25849773) Lee AS … Cate JH (Nature 2015) 3 4 60
  3. Genetic heterogeneity in colorectal cancer associations between African and European americans. (PMID: 20659471) Kupfer SS … Ellis NA (Gastroenterology 2010) 3 45 60
  4. The utility and predictive value of combinations of low penetrance genes for screening and risk prediction of colorectal cancer. (PMID: 20437058) Hawken SJ … Little J (Human genetics 2010) 3 45 60
  5. MYC and EIF3H Coamplification significantly improve response and survival of non-small cell lung cancer patients (NSCLC) treated with gefitinib. (PMID: 19204574) Cappuzzo F … Gemmill R (Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer 2009) 3 45 60

Products for EIF3H Gene

  • Addgene plasmids for EIF3H

Sources for EIF3H Gene

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