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Aliases for EIF3G Gene

Aliases for EIF3G Gene

  • Eukaryotic Translation Initiation Factor 3 Subunit G 2 3 5
  • Eukaryotic Translation Initiation Factor 3, Subunit 4 Delta, 44kDa 2 3
  • Eukaryotic Translation Initiation Factor 3 RNA-Binding Subunit 3 4
  • EIF3S4 3 4
  • Eukaryotic Translation Initiation Factor 3 Subunit P42 3
  • Eukaryotic Translation Initiation Factor 3, Subunit G 2
  • Eukaryotic Translation Initiation Factor 3 Subunit 4 4
  • EIF-3 RNA-Binding Subunit 4
  • EIF-3-Delta 4
  • EIF3-Delta 3
  • EIF3-P42 3
  • EIF3-P44 3
  • EIF3 P42 4
  • EIF3 P44 4
  • EIF3g 4

External Ids for EIF3G Gene

Previous HGNC Symbols for EIF3G Gene

  • EIF3S4

Previous GeneCards Identifiers for EIF3G Gene

  • GC19M010091
  • GC19M010225
  • GC19M009806

Summaries for EIF3G Gene

Entrez Gene Summary for EIF3G Gene

  • This gene encodes a core subunit of the eukaryotic translation initiation factor 3 (eIF3) complex, which is required for initiation of protein translation. An N-terminal caspase cleavage product of the encoded protein may stimulate degradation of DNA. A mutation in this gene is associated with narcolepsy. [provided by RefSeq, Jul 2016]

GeneCards Summary for EIF3G Gene

EIF3G (Eukaryotic Translation Initiation Factor 3 Subunit G) is a Protein Coding gene. Diseases associated with EIF3G include Narcolepsy and Lymphocytic Choriomeningitis. Among its related pathways are Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S and Apoptotic Pathways in Synovial Fibroblasts. GO annotations related to this gene include nucleic acid binding and nucleotide binding.

UniProtKB/Swiss-Prot for EIF3G Gene

  • RNA-binding component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis (PubMed:17581632, PubMed:25849773, PubMed:27462815). The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation (PubMed:17581632). The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, including cell cycling, differentiation and apoptosis, and uses different modes of RNA stem-loop binding to exert either translational activation or repression (PubMed:25849773). This subunit can bind 18S rRNA.

  • (Microbial infection) In case of FCV infection, plays a role in the ribosomal termination-reinitiation event leading to the translation of VP2 (PubMed:18056426).

Gene Wiki entry for EIF3G Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for EIF3G Gene

Genomics for EIF3G Gene

Regulatory Elements for EIF3G Gene

Enhancers for EIF3G Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH19F010100 1.2 FANTOM5 ENCODE 39.3 +15.5 15536 8.3 HDGF PKNOX1 CREB3L1 MLX WRNIP1 ZFP64 ARID4B SIN3A YBX1 DMAP1 FBXL12 ZNF699 ZNF561 LOC100419831 ZNF559 TIMM29 YIPF2 ZNF562 EIF3G ZNF121
GH19F010717 0.8 FANTOM5 ENCODE 34.5 -599.2 -599233 3.7 HDGF PKNOX1 ARNT CREB3L1 WRNIP1 ARID4B SIN3A FEZF1 ZNF2 YY1 FBXL12 EIF3G DOCK6 ZNF627 LOC100419831 RAVER1 S1PR2 HNRNPA1P10 KANK2 SLC44A2
GH19F010501 0.2 ENCODE 28.4 -382.6 -382594 3.0 HDGF PKNOX1 CREB3L1 ARID4B SIN3A DMAP1 ZNF2 YY1 ZNF207 ZNF143 FBXL12 EIF3G ZNF561 RAVER1 MIR1181 ZNF426 SWSAP1 S1PR2 YIPF2 TIMM29
GH19F009620 1 FANTOM5 ENCODE 27.4 +498.0 498033 3.1 PKNOX1 ARNT CREB3L1 ARID4B SIN3A DMAP1 ZNF2 YY1 SLC30A9 ZNF143 ZNF561 ZNF558 FBXL12 EIF3G ENSG00000269300 ZNF699 ZNF846 LOC100128428 MIR1181 LOC100419831
GH19F009834 0.9 ENCODE 27 +284.6 284604 2.1 HDGF PKNOX1 ARID4B SIN3A YBX1 DMAP1 YY1 ZNF143 ZNF207 FOS FBXL12 ZNF699 EIF3G ZNF559 ZNF426 MIR1181 RAVER1 ZNF561 LOC100996288 PIR54152
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around EIF3G on UCSC Golden Path with GeneCards custom track

Promoters for EIF3G Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000343224 123 1201 HDGF PKNOX1 CREB3L1 ARID4B SIN3A DMAP1 ZNF2 SLC30A9 ZNF207 ZNF143

Genomic Location for EIF3G Gene

Chromosome:
19
Start:
10,115,014 bp from pter
End:
10,119,923 bp from pter
Size:
4,910 bases
Orientation:
Minus strand

Genomic View for EIF3G Gene

Genes around EIF3G on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
EIF3G Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for EIF3G Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for EIF3G Gene

Proteins for EIF3G Gene

  • Protein details for EIF3G Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O75821-EIF3G_HUMAN
    Recommended name:
    Eukaryotic translation initiation factor 3 subunit G
    Protein Accession:
    O75821
    Secondary Accessions:
    • O14801
    • Q969U5

    Protein attributes for EIF3G Gene

    Size:
    320 amino acids
    Molecular mass:
    35611 Da
    Quaternary structure:
    • Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is composed of 13 subunits: EIF3A, EIF3B, EIF3C, EIF3D, EIF3E, EIF3F, EIF3G, EIF3H, EIF3I, EIF3J, EIF3K, EIF3L and EIF3M. The eIF-3 complex appears to include 3 stable modules: module A is composed of EIF3A, EIF3B, EIF3G and EIF3I; module B is composed of EIF3F, EIF3H, and EIF3M; and module C is composed of EIF3C, EIF3D, EIF3E, EIF3K and EIF3L. EIF3C of module C binds EIF3B of module A and EIF3H of module B, thereby linking the three modules. EIF3J is a labile subunit that binds to the eIF-3 complex via EIF3B. The eIF-3 complex interacts with RPS6KB1 under conditions of nutrient depletion. Mitogenic stimulation leads to binding and activation of a complex composed of MTOR and RPTOR, leading to phosphorylation and release of RPS6KB1 and binding of EIF4B to eIF-3. Interacts (via C-terminus) with AIFM1 (via N-terminus).

    Three dimensional structures from OCA and Proteopedia for EIF3G Gene

neXtProt entry for EIF3G Gene

Post-translational modifications for EIF3G Gene

  • Phosphorylated. Phosphorylation is enhanced upon serum stimulation.
  • Ubiquitination at Lys 65 and Lys 180
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for EIF3G Gene

Domains & Families for EIF3G Gene

Suggested Antigen Peptide Sequences for EIF3G Gene

Graphical View of Domain Structure for InterPro Entry

O75821

UniProtKB/Swiss-Prot:

EIF3G_HUMAN :
  • Contains 1 RRM (RNA recognition motif) domain.
  • Belongs to the eIF-3 subunit G family.
Domain:
  • Contains 1 RRM (RNA recognition motif) domain.
Family:
  • Belongs to the eIF-3 subunit G family.
genes like me logo Genes that share domains with EIF3G: view

Function for EIF3G Gene

Molecular function for EIF3G Gene

UniProtKB/Swiss-Prot Function:
RNA-binding component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis (PubMed:17581632, PubMed:25849773, PubMed:27462815). The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation (PubMed:17581632). The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, including cell cycling, differentiation and apoptosis, and uses different modes of RNA stem-loop binding to exert either translational activation or repression (PubMed:25849773). This subunit can bind 18S rRNA.
UniProtKB/Swiss-Prot Function:
(Microbial infection) In case of FCV infection, plays a role in the ribosomal termination-reinitiation event leading to the translation of VP2 (PubMed:18056426).

Gene Ontology (GO) - Molecular Function for EIF3G Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000166 nucleotide binding IEA --
GO:0003676 nucleic acid binding IEA --
GO:0003723 RNA binding IEA,IDA 25849773
GO:0003743 contributes_to translation initiation factor activity IEA,IDA 17581632
GO:0005515 protein binding IPI 14688252
genes like me logo Genes that share ontologies with EIF3G: view
genes like me logo Genes that share phenotypes with EIF3G: view

Animal Model Products

miRNA for EIF3G Gene

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for EIF3G Gene

Localization for EIF3G Gene

Subcellular locations from UniProtKB/Swiss-Prot for EIF3G Gene

Cytoplasm. Nucleus. Cytoplasm, perinuclear region. Note=Colocalizes with AIFM1 in the nucleus and perinuclear region.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for EIF3G Gene COMPARTMENTS Subcellular localization image for EIF3G gene
Compartment Confidence
cytosol 5
nucleus 3

Gene Ontology (GO) - Cellular Components for EIF3G Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 NOT nucleus IDA 12426392
GO:0005737 cytoplasm IEA,IDA 12426392
GO:0005829 cytosol TAS --
GO:0005852 eukaryotic translation initiation factor 3 complex IEA,IDA 17322308
GO:0016282 eukaryotic 43S preinitiation complex IEA --
genes like me logo Genes that share ontologies with EIF3G: view

Pathways & Interactions for EIF3G Gene

genes like me logo Genes that share pathways with EIF3G: view

Gene Ontology (GO) - Biological Process for EIF3G Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001731 formation of translation preinitiation complex IEA --
GO:0006412 translation IEA --
GO:0006413 translational initiation IEA,TAS --
GO:0006446 regulation of translational initiation IEA --
GO:0075525 viral translational termination-reinitiation IDA 21347434
genes like me logo Genes that share ontologies with EIF3G: view

No data available for SIGNOR curated interactions for EIF3G Gene

Transcripts for EIF3G Gene

Unigene Clusters for EIF3G Gene

Eukaryotic translation initiation factor 3, subunit G:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for EIF3G Gene

ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3a · 3b · 3c · 3d ^ 4a · 4b ^ 5a · 5b ^ 6 ^ 7a · 7b ^ 8a · 8b · 8c · 8d ^ 9a · 9b · 9c ^ 10a · 10b ^ 11a ·
SP1: - - - - - -
SP2: - - - - - -
SP3: - - - - - - -
SP4: - - -
SP5: - - - - - -
SP6: - - - -
SP7: - - - -
SP8: - - -
SP9: - - - -
SP10: -
SP11: - - -
SP12: - -
SP13: - -
SP14:

ExUns: 11b ^ 12
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:
SP13:
SP14:

Relevant External Links for EIF3G Gene

GeneLoc Exon Structure for
EIF3G
ECgene alternative splicing isoforms for
EIF3G

Expression for EIF3G Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for EIF3G Gene

Protein differential expression in normal tissues from HIPED for EIF3G Gene

This gene is overexpressed in Bone marrow stromal cell (7.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for EIF3G Gene



Protein tissue co-expression partners for EIF3G Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of EIF3G Gene:

EIF3G

SOURCE GeneReport for Unigene cluster for EIF3G Gene:

Hs.529059
genes like me logo Genes that share expression patterns with EIF3G: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for EIF3G Gene

Orthologs for EIF3G Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for EIF3G Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia EIF3G 34 35
  • 99.48 (n)
cow
(Bos Taurus)
Mammalia EIF3G 34 35
  • 92.6 (n)
dog
(Canis familiaris)
Mammalia EIF3G 34 35
  • 91.67 (n)
mouse
(Mus musculus)
Mammalia Eif3g 34 16 35
  • 89.17 (n)
rat
(Rattus norvegicus)
Mammalia Eif3g 34
  • 88.75 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia EIF3G 35
  • 88 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia -- 35
  • 87 (a)
OneToMany
-- 35
  • 60 (a)
OneToMany
chicken
(Gallus gallus)
Aves EIF3G 34
  • 85.93 (n)
lizard
(Anolis carolinensis)
Reptilia EIF3G 35
  • 82 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia eif3s4 34
  • 74.87 (n)
zebrafish
(Danio rerio)
Actinopterygii eif3g 34 35
  • 78.01 (n)
-- 34
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.9507 34
fruit fly
(Drosophila melanogaster)
Insecta CG10881 34 35
  • 57.28 (n)
CG8636 35
  • 48 (a)
OneToMany
African malaria mosquito
(Anopheles gambiae)
Insecta EIF3G_ANOGA 34
  • 56.77 (n)
worm
(Caenorhabditis elegans)
Secernentea eif-3.G 34 35
  • 49.92 (n)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_ADR189W 34
  • 47.6 (n)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0B00847g 34
  • 47.16 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes TIF35 34 35 37
  • 43.9 (n)
rice
(Oryza sativa)
Liliopsida Os02g0788400 34
  • 53.77 (n)
bread mold
(Neurospora crassa)
Ascomycetes NCU08046 34
  • 54.39 (n)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes tif35 34
  • 50.5 (n)
Species where no ortholog for EIF3G was found in the sources mined by GeneCards:
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for EIF3G Gene

ENSEMBL:
Gene Tree for EIF3G (if available)
TreeFam:
Gene Tree for EIF3G (if available)

Paralogs for EIF3G Gene

No data available for Paralogs for EIF3G Gene

Variants for EIF3G Gene

Sequence variations from dbSNP and Humsavar for EIF3G Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
rs2305795 other 10,115,376(+) CAGCC(A/G)GGGGA intron-variant, utr-variant-3-prime
rs3826784 other 10,116,334(+) GGGGC(A/G)GCAGC intron-variant
rs10401388 -- 10,120,736(+) aaggc(A/G)tgggg upstream-variant-2KB
rs10402441 -- 10,121,249(+) CCTAA(A/G)AAGGG upstream-variant-2KB
rs111350427 -- 10,119,174(+) TGTCT(G/T)CAAAA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for EIF3G Gene

Variant ID Type Subtype PubMed ID
nsv833743 CNV loss 17160897

Variation tolerance for EIF3G Gene

Residual Variation Intolerance Score: 27.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.55; 11.90% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for EIF3G Gene

Human Gene Mutation Database (HGMD)
EIF3G
SNPedia medical, phenotypic, and genealogical associations of SNPs for
EIF3G

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for EIF3G Gene

Disorders for EIF3G Gene

MalaCards: The human disease database

(2) MalaCards diseases for EIF3G Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
narcolepsy
  • narcolepsy, without cataplexy
lymphocytic choriomeningitis
  • lcm
- elite association - COSMIC cancer census association via MalaCards
Search EIF3G in MalaCards View complete list of genes associated with diseases

Relevant External Links for EIF3G

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
EIF3G
genes like me logo Genes that share disorders with EIF3G: view

No data available for UniProtKB/Swiss-Prot and Genatlas for EIF3G Gene

Publications for EIF3G Gene

  1. Characterization of cDNAs encoding the p44 and p35 subunits of human translation initiation factor eIF3. (PMID: 9822659) Block K.L. … Hershey J.W.B. (J. Biol. Chem. 1998) 2 3 4 22 64
  2. eIF3d is an mRNA cap-binding protein that is required for specialized translation initiation. (PMID: 27462815) Lee A.S. … Cate J.H. (Nature 2016) 3 4 64
  3. eIF3 targets cell-proliferation messenger RNAs for translational activation or repression. (PMID: 25849773) Lee A.S. … Cate J.H. (Nature 2015) 3 4 64
  4. Mass spectrometry reveals modularity and a complete subunit interaction map of the eukaryotic translation factor eIF3. (PMID: 18599441) Zhou M. … Robinson C.V. (Proc. Natl. Acad. Sci. U.S.A. 2008) 3 4 64
  5. Structural characterization of the human eukaryotic initiation factor 3 protein complex by mass spectrometry. (PMID: 17322308) Damoc E. … Leary J.A. (Mol. Cell. Proteomics 2007) 3 4 64

Products for EIF3G Gene

Sources for EIF3G Gene

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