Aliases for EIF3G Gene
- Eukaryotic Translation Initiation Factor 3 Subunit G 2 3 5
- Eukaryotic Translation Initiation Factor 3, Subunit 4 Delta, 44kDa 2 3
- Eukaryotic Translation Initiation Factor 3 RNA-Binding Subunit 3 4
- EIF3S4 3 4
- Eukaryotic Translation Initiation Factor 3 Subunit P42 3
- Eukaryotic Translation Initiation Factor 3, Subunit G 2
- Eukaryotic Translation Initiation Factor 3 Subunit 4 4
- EIF-3 RNA-Binding Subunit 4
External Ids for EIF3G Gene
Previous HGNC Symbols for EIF3G Gene
Previous GeneCards Identifiers for EIF3G Gene
This gene encodes a core subunit of the eukaryotic translation initiation factor 3 (eIF3) complex, which is required for initiation of protein translation. An N-terminal caspase cleavage product of the encoded protein may stimulate degradation of DNA. A mutation in this gene is associated with narcolepsy. [provided by RefSeq, Jul 2016]
GeneCards Summary for EIF3G Gene
EIF3G (Eukaryotic Translation Initiation Factor 3 Subunit G) is a Protein Coding gene. Diseases associated with EIF3G include Narcolepsy and Parainfluenza Virus Type 3. Among its related pathways are Viral mRNA Translation and Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S. GO annotations related to this gene include nucleic acid binding and nucleotide binding.
UniProtKB/Swiss-Prot for EIF3G Gene
RNA-binding component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis (PubMed:17581632, PubMed:25849773, PubMed:27462815). The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation (PubMed:17581632). The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, including cell cycling, differentiation and apoptosis, and uses different modes of RNA stem-loop binding to exert either translational activation or repression (PubMed:25849773). This subunit can bind 18S rRNA.
(Microbial infection) In case of FCV infection, plays a role in the ribosomal termination-reinitiation event leading to the translation of VP2 (PubMed:18056426).