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EIF3G Gene

protein-coding   GIFtS: 58
GCID: GC19M010225

Eukaryotic Translation Initiation Factor 3, Subunit G

(Previous names: eukaryotic translation initiation factor 3, subunit 4 delta,...)
(Previous symbol: EIF3S4)
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Eukaryotic Translation Initiation Factor 3, Subunit G1 2     EIF3 P442 3
EIF3S41 2 3 5     EIF3-P422
Eukaryotic Translation Initiation Factor 3, Subunit 4 Delta, 44kDa1 2     eIF3-delta2
Eukaryotic Translation Initiation Factor 3 RNA-Binding Subunit2 3     eIF3-p442
Eukaryotic Translation Initiation Factor 3 Subunit 42 3     Eukaryotic Translation Initiation Factor 3 Subunit G2
eIF-3-delta2 3     Eukaryotic Translation Initiation Factor 3 Subunit P422
EIF-3 RNA-Binding Subunit2 3     Eukaryotic Translation Initiation Factor 3, Subunit 4 (Delta, 44kD)2
EIF3 P422 3     eIF3g3

External Ids:    HGNC: 32741   Entrez Gene: 86662   Ensembl: ENSG000001308117   OMIM: 6039135   UniProtKB: O758213   

Export aliases for EIF3G gene to outside databases

Previous GC identifers: GC19M010091 GC19M009806


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for EIF3G Gene:
EIF3G (eukaryotic translation initiation factor 3, subunit G) is a protein-coding gene. GO annotations related to this gene include nucleotide binding and translation initiation factor activity.

UniProtKB/Swiss-Prot: EIF3G_HUMAN, O75821
Function: Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for
several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and
facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S preinitiation
complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG
recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal
complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation.
This subunit can bind 18S rRNA

Gene Wiki entry for EIF3G Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000019.9  NC_018930.2  NT_011295.12  
Regulatory elements:
   Regulatory transcription factor binding sites in the EIF3G gene promoter:
         AP-4   GATA-2   AREB6   Ik-2   FOXO1a   ZIC2/Zic2   LyF-1   FOXO1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidEIF3G promoter sequence
   Search Chromatin IP Primers for EIF3G

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat EIF3G


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19p13.2   Ensembl cytogenetic band:  19p13.2   HGNC cytogenetic band: 19p13.2

EIF3G Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
EIF3G gene location

GeneLoc information about chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19M010225:  view genomic region     (about GC identifiers)

Start:
10,225,690 bp from pter      End:
10,230,599 bp from pter
Size:
4,910 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: EIF3G_HUMAN, O75821 (See protein sequence)
Recommended Name: Eukaryotic translation initiation factor 3 subunit G  
Size: 320 amino acids; 35611 Da
Subunit: Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is composed of 13
subunits: EIF3A, EIF3B, EIF3C, EIF3D, EIF3E, EIF3F, EIF3G, EIF3H, EIF3I, EIF3J, EIF3K, EIF3L and EIF3M. The eIF-3
complex appears to include 3 stable modules: module A is composed of EIF3A, EIF3B, EIF3G and EIF3I; module B is
composed of EIF3F, EIF3H, and EIF3M; and module C is composed of EIF3C, EIF3D, EIF3E, EIF3K and EIF3L. EIF3C of
module C binds EIF3B of module A and EIF3H of module B, thereby linking the three modules. EIF3J is a labile
subunit that binds to the eIF-3 complex via EIF3B. The eIF-3 complex interacts with RPS6KB1 under conditions of
nutrient depletion. Mitogenic stimulation leads to binding and activation of a complex composed of MTOR and
RPTOR, leading to phosphorylation and release of RPS6KB1 and binding of EIF4B to eIF-3. Interacts (via
C-terminus) with AIFM1 (via N-terminus)
Mass spectrometry: Mass=35639.8; Method=Unknown; Range=1-320; Source=PubMed:17322308;
Mass spectrometry: Mass=35481.1; Mass_error=0.4; Method=MALDI; Range=1-320; Source=PubMed:18599441;
1 PDB 3D structure from and Proteopedia for EIF3G:
2CQ0 (3D)    
Secondary accessions: O14801 Q969U5

Explore the universe of human proteins at neXtProt for EIF3G: NX_O75821

Explore proteomics data for EIF3G at MOPED

Post-translational modifications: 

  • Phosphorylated. Phosphorylation is enhanced upon serum stimulation1
  • Ubiquitination2 at Lys65, Lys180
  • Modification sites at PhosphoSitePlus

  • See EIF3G Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_003746.2  
    ENSEMBL proteins: 
     ENSP00000253108   ENSP00000467187   ENSP00000466860   ENSP00000468159   ENSP00000465882  
     ENSP00000466943   ENSP00000465933   ENSP00000468313   ENSP00000465925  
    Reactome Protein details: O75821

    EIF3G Human Recombinant Protein Products:

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    Novus Biologicals EIF3G Proteins
    Novus Biologicals EIF3G Lysates
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    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for EIF3G

     
    Search eBioscience for Proteins for EIF3G 

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    Search eBioscience for ELISAs for EIF3G 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    RBM: RNA binding motif (RRM) containing

    4 InterPro protein domains:
     IPR024675 eIF3g_N
     IPR017334 eIF3_g
     IPR000504 RRM_dom
     IPR012677 Nucleotide-bd_a/b_plait

    Graphical View of Domain Structure for InterPro Entry O75821

    ProtoNet protein and cluster: O75821

    1 Blocks protein domain: IPB000504 RNA-binding region RNP-1 (RNA recognition motif)

    UniProtKB/Swiss-Prot: EIF3G_HUMAN, O75821
    Similarity: Belongs to the eIF-3 subunit G family
    Similarity: Contains 1 RRM (RNA recognition motif) domain


    Find genes that share domains with EIF3G           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: EIF3G_HUMAN, O75821
    Function: Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for
    several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and
    facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S preinitiation
    complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG
    recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal
    complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation.
    This subunit can bind 18S rRNA

         Gene Ontology (GO): 5 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000166nucleotide binding IEA--
    GO:0003676nucleic acid binding ----
    GO:0003743contributes to translation initiation factor activity IDA17581632
    GO:0005515protein binding IPI14688252
    GO:0044822poly(A) RNA binding IDA--
         
    Find genes that share ontologies with EIF3G           About GenesLikeMe


    Phenotypes:
         8 GenomeRNAi human phenotypes for EIF3G:
     Decreased G3BP1 protein expres  Decreased influenza A H1N1 (A/  Decreased influenza A/WSN/33 r  Decreased viability 
     Increased S DNA content  Increased cell death in HCT116  S arrest  Synthetic lethal with Ras 

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for EIF3G
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       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for EIF3G

    miRNA
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    miRTarBase miRNAs that target EIF3G:
    hsa-mir-186-5p (MIRT045194), hsa-mir-425-5p (MIRT039322), hsa-mir-92a-3p (MIRT049415), hsa-mir-155-5p (MIRT020496)

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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for EIF3G


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    EIF3G_HUMAN, O75821: Cytoplasm (By similarity). Nucleus. Cytoplasm, perinuclear region. Note=Colocalizes with
    AIFM1 in the nucleus and perinuclear region
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    cytosol4

    Gene Ontology (GO): Selected cellular component terms (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IEA--
    GO:0005737cytoplasm ----
    GO:0005829cytosol TAS--
    GO:0005852eukaryotic translation initiation factor 3 complex IDA17322308
    GO:0016282eukaryotic 43S preinitiation complex IEA--

    Find genes that share ontologies with EIF3G           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for EIF3G About   (see all 6)  
    See pathways by source

    SuperPathContained pathways About
    1Influenza Viral RNA Transcription and Replication
    L13a-mediated translational silencing of Ceruloplasmin expression0.94
    Cap-dependent Translation Initiation0.89
    Formation of a pool of free 40S subunits0.94
    Eukaryotic Translation Initiation0.89
    GTP hydrolysis and joining of the 60S ribosomal subunit0.93
    Translation0.82
    2Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S
    Translation initiation complex formation0.91
    Formation of the ternary complex, and subsequently, the 43S complex0.91
    Ribosomal scanning and start codon recognition0.91
    Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S0.90
    3Gene Expression
    Gene Expression0.40
    4Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein
    Metabolism of proteins0.30
    5Translation Factors
    Translation Factors


    Find genes that share SuperPaths with EIF3G           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    2 Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for EIF3G
        eIF2 Pathway
    mTOR Pathway

    1 BioSystems Pathway for EIF3G
        Translation Factors


    Selected Reactome Pathways for EIF3G (see all 6)
        Formation of the ternary complex, and subsequently, the 43S complex
    L13a-mediated translational silencing of Ceruloplasmin expression
    GTP hydrolysis and joining of the 60S ribosomal subunit
    Ribosomal scanning and start codon recognition
    Formation of a pool of free 40S subunits


    1 Kegg Pathway  (Kegg details for EIF3G):
        RNA transport

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for EIF3G
    Interactions:

        Search GeneGlobe Interaction Network for EIF3G

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for EIF3G (O758211, 2, 3 ENSP000002531084) via UniProtKB, MINT, STRING, and/or I2D (see all 963)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    AIFM1O958311, 2, 3, ENSP000002872954EBI-366632,EBI-356440 MINT-3388512 MINT-3388489 MINT-3388414 MINT-3388563 MINT-3388584 MINT-3388603 MINT-3388464 MINT-3388536 MINT-3388652 I2D: score=2 STRING: ENSP00000287295
    EIF3BP558841, 2, 3, ENSP000003541254EBI-366632,EBI-366696 MINT-7947479 I2D: score=11 STRING: ENSP00000354125
    DDX39BQ138382, 3MINT-7945693 MINT-7947479 I2D: score=1 
    ENSG00000215425Q138382, 3MINT-7945693 MINT-7947479 I2D: score=1 
    ENSG00000225073Q138382, 3MINT-7945693 MINT-7947479 I2D: score=1 
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001731formation of translation preinitiation complex IEA--
    GO:0006412translation TAS--
    GO:0006413translational initiation TAS--
    GO:0006446regulation of translational initiation IEA--
    GO:0010467gene expression TAS--

    Find genes that share ontologies with EIF3G           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for EIF3G



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for EIF3G gene: 
    NM_003755.3  

    Unigene Cluster for EIF3G:

    Eukaryotic translation initiation factor 3, subunit G
    Hs.529059  [show with all ESTs]
    Unigene Representative Sequence: AK316335
    Selected Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 19):
    ENST00000253108(uc002mnd.3 uc010dxa.3 uc010xlb.2) ENST00000593054
    ENST00000590158 ENST00000589454 ENST00000587146 ENST00000588709 ENST00000589009
    ENST00000587590 ENST00000593066 ENST00000589674 ENST00000593095 ENST00000587993
    ENST00000586151 ENST00000590940 ENST00000589458 ENST00000587681 ENST00000587168
    ENST00000592485
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    Primer
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    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat EIF3G
      QuantiTect SYBR Green Assays in human, mouse, rat EIF3G
      QuantiFast Probe-based Assays in human, mouse, rat EIF3G

    Additional mRNA sequence: 

    AF020833.1 AF094850.1 AK291320.1 AK293374.1 AK296377.1 AK309944.1 AK311624.1 AK315896.1 
    AK316040.1 AK316335.1 BC000733.2 BC008469.1 BT006889.1 CR457134.1 U96074.1 

    20 DOTS entries:

    DT.416893  DT.100708615  DT.95275809  DT.100884257  DT.211499  DT.97774289  DT.432149  DT.86835841 
    DT.95275817  DT.100038996  DT.91932893  DT.100884259  DT.92459155  DT.95256602  DT.100884267  DT.121500271 
    DT.121500277  DT.75119977  DT.121500315  DT.91862120 

    Selected AceView cDNA sequences (see all 631):

    BX358131 CR598702 BG769924 AA405285 BU528407 BU155038 BU194713 BI457308 
    CB160342 BM771540 BE514642 BM015768 BG536860 BQ931878 BG777445 BG390126 
    CR611551 CD519037 BQ674076 BQ436979 BQ668618 BE741309 CR613864 CB140784 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for EIF3G (see all 14)    About this scheme

    ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3a · 3b · 3c · 3d ^ 4a · 4b ^ 5a · 5b ^ 6 ^ 7a · 7b ^ 8a · 8b · 8c · 8d ^ 9a · 9b · 9c ^ 10a · 10b ^ 11a ·
    SP1:                                -     -                 -                 -     -                                         -                                 
    SP2:                                -     -                 -                 -     -                                         -                                 
    SP3:                                -     -                 -                 -     -                                   -     -                                 
    SP4:                                                                          -     -                                         -                                 
    SP5:                                                        -                 -     -     -     -                             -                                 

    ExUns: 11b ^ 12
    SP1:            
    SP2:            
    SP3:            
    SP4:            
    SP5:            


    ECgene alternative splicing isoforms for EIF3G

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    EIF3G expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CAGCCCAACC
    EIF3G Expression
    About this image


    EIF3G expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 20) fully expand
     
     Brain (Nervous System)    fully expand to see all 2 entries
             Cerebral Cortex
     
     Testis (Reproductive System)
             Leydig Cells Testis Interstitium
     
     Ovary (Reproductive System)
             Oviduct
     
     Pancreas (Endocrine System)
             Islets of Langerhans
     
     Trophoblast (Extraembryonic Tissues)
             Trophoblast Cells Trophoblast
    EIF3G Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    EIF3G Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.529059
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of eukaryotes.

    Orthologs for EIF3G gene from Selected species (see all 23)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Eif3g1 , 5 eukaryotic translation initiation factor 3, subunit more1, 5 89.17(n)1
    98.44(a)1
      9 (7.66 cM)5
    533561  NM_016876.31  NP_058572.21 
     208943495 
    chicken
    (Gallus gallus)
    Aves EIF3G1 eukaryotic translation initiation factor 3, subunit more 85.93(n)
    94.44(a)
      101747413  XM_004950477.1  XP_004950534.1 
    lizard
    (Anolis carolinensis)
    Reptilia EIF3G6
    eukaryotic translation initiation factor 3, subuni...
    82(a)
    1 ↔ 1
    GL343414.1(684168-708235)
    African clawed frog
    (Xenopus laevis)
    Amphibia BX850074.12   -- 78.51(n)    BX850074.1 
    zebrafish
    (Danio rerio)
    Actinopterygii BC049046.12   -- 80.88(n)   393974  BC049046.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG108811 CG10881 57.28(n)
    48.57(a)
      42422  NM_142630.2  NP_650887.1 
    worm
    (Caenorhabditis elegans)
    Secernentea eif-3.G1 eif-3.G 49.92(n)
    40.93(a)
      174346  NM_063377.3  NP_495778.1 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes TIF35(YDR429C)4
    TIF351
    eIF3g subunit of the core complex of translation initiation more4
    TIF351
    43.9(n)1
    36.63(a)1
      4(1325301-1324477)4
    8520391, 4  NP_010717.11, 4 
    rice
    (Oryza sativa)
    Liliopsida Os02g07884001 Os02g0788400 53.77(n)
    49.57(a)
      4330963  NM_001054882.1  NP_001048347.1 


    ENSEMBL Gene Tree for EIF3G (if available)
    TreeFam Gene Tree for EIF3G (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for EIF3G gene
    Selected SIMAP similar genes for EIF3G using alignment to 9 protein entries:     EIF3G_HUMAN (see all proteins) (see all similar genes):
    ARL6IP5    C1orf143    TGM4    TNNT1    VPS33A    EIF3S4
    RRM2B    ADCK1    FLJ00047    KIAA1651    LSM12    NEK4
    SMYD4    SPG7    CDK10    AARSD1    IK    RPS13

    Find genes that share paralogs with EIF3G           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for EIF3G (see all 205)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 19 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1175164371,2
    C,F--10226579(+) CGCTTC/TGGGGA 1 -- int11Minor allele frequency- T:0.03NA 120
    rs1461135471,2
    C--10226613(+) CCCACC/TCACCA 1 -- int10--------
    rs2019994771,2
    C--10226615(+) CACCCA/GCCAGC 1 -- int10--------
    rs1489289111,2
    C--10226625(+) CCTGG-/CGTCGGGG 1 -- int10--------
    rs1923667291,2
    --10226661(+) CTGCAC/TGGACT 2 M V mis10--------
    rs2004904411,2
    C--10226686(+) GCCCCA/GTCGCG 2 D syn10--------
    rs285107921,2
    C,F,H--10226701(+) CTCGGC/TGGCAC 2 P syn1 ese310Minor allele frequency- T:0.05NS NA WA 5304
    rs1123179531,2
    C--10226753(+) GCTCTC/GGGGAC 1 -- int10--------
    rs1488048791,2
    C--10226791(+) GTGGCA/GCAGGC 1 -- int10--------
    rs1415687411,2
    --10226887(+) GCCACA/GAGGAC 1 -- int10--------

    HapMap Linkage Disequilibrium report for EIF3G (10225690 - 10230599 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for EIF3G:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv911028CNV Loss21882294
    nsv833743CNV Loss17160897

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing EIF3G
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 603913    OMIM disorders: --


    Find genes that share disorders with EIF3G           About GenesLikeMe


    Export disorders for EIF3G gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for EIF3G gene, integrated from 10 sources (see all 52):
    (articles sorted by number of sources associating them with EIF3G)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Characterization of cDNAs encoding the p44 and p35 subunits of human translation initiation factor eIF3. (PubMed id 9822659)1, 2, 3, 9 Block K.L.... Hershey J.W.B. (J. Biol. Chem. 1998)
    2. Mass spectrometry reveals modularity and a complete subunit interaction map of the eukaryotic translation factor eIF3. (PubMed id 18599441)1, 2 Zhou M.... Robinson C.V. (Proc. Natl. Acad. Sci. U.S.A. 2008)
    3. Reconstitution reveals the functional core of mammalian eIF3. (PubMed id 17581632)1, 2 Masutani M.... Imataka H. (EMBO J. 2007)
    4. Structural characterization of the human eukaryotic initiation factor 3 protein complex by mass spectrometry. (PubMed id 17322308)1, 2 Damoc E.... Leary J.A. (Mol. Cell. Proteomics 2007)
    5. Apoptosis-inducing factor (AIF) inhibits protein synthesis by interacting with the eukaryotic translation initiation factor 3 subunit p44 (eIF3g). (PubMed id 17094969)1, 2 Kim J.T.... Lim J.S. (FEBS Lett. 2006)
    6. The j-subunit of human translation initiation factor eIF3 is required for the stable binding of eIF3 and its subcomplexes to 40 S ribosomal subunits in vitro. (PubMed id 14688252)1, 2 Fraser C.S....Hershey J.W.B. (J. Biol. Chem. 2004)
    7. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    8. Characterization of eIF3k: a newly discovered subunit of mammalian translation initiation factor eIF3. (PubMed id 14519125)1, 2 Mayeur G.L.... Hershey J.W.B. (Eur. J. Biochem. 2003)
    9. Cloning and characterization of the p42 subunit of mammalian translation initiation factor 3 (eIF3): demonstration that eIF3 interacts with eIF5 in mammalian cells. (PubMed id 9973622)1, 2 Bandyopadhyay A. and Maitra U. (Nucleic Acids Res. 1999)
    10. The intracellular interactome of tetraspanin-enriched microdomains reveals their function as sorting machineries toward exosomes. (PubMed id 23463506)1 Perez-Hernandez D....YA!A+ez-MA^ M. (J. Biol. Chem. 2013)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 8666 HGNC: 3274 AceView: EIF3S4 Ensembl:ENSG00000130811 euGenes: HUgn8666
    ECgene: EIF3G Kegg: 8666 H-InvDB: EIF3G

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for EIF3G Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for EIF3G gene:
    Search GeneIP for patents involving EIF3G

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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