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Aliases for EIF3F Gene

Aliases for EIF3F Gene

  • Eukaryotic Translation Initiation Factor 3, Subunit F 2 3
  • EIF3S5 3 4 6
  • Eukaryotic Translation Initiation Factor 3, Subunit 5 Epsilon, 47kDa 2 3
  • Deubiquitinating Enzyme EIF3f 3 4
  • EIF-3-Epsilon 3 4
  • Eukaryotic Translation Initiation Factor 3, Subunit 5 (Epsilon, 47kD) 3
  • Eukaryotic Translation Initiation Factor 3 Subunit F 3
  • Eukaryotic Translation Initiation Factor 3 Subunit 5 4
  • EIF3-Epsilon 3
  • EC 3.4.19.12 4
  • EIF3-P47 3
  • EIF3 P47 4
  • EIF3f 4

External Ids for EIF3F Gene

Previous Symbols for EIF3F Gene

  • EIF3S5

Summaries for EIF3F Gene

GeneCards Summary for EIF3F Gene

EIF3F (Eukaryotic Translation Initiation Factor 3, Subunit F) is a Protein Coding gene. Among its related pathways are p70S6K Signaling and Apoptotic Pathways in Synovial Fibroblasts. GO annotations related to this gene include cysteine-type peptidase activity and translation initiation factor activity. An important paralog of this gene is PSMD7.

UniProtKB/Swiss-Prot for EIF3F Gene

  • Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S preinitiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation.

  • Deubiquitinates activated NOTCH1, promoting its nuclear import, thereby acting as a positive regulator of Notch signaling.

Gene Wiki entry for EIF3F Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for EIF3F Gene

Genomics for EIF3F Gene

Genomic Location for EIF3F Gene

Start:
7,970,251 bp from pter
End:
8,001,862 bp from pter
Size:
31,612 bases
Orientation:
Plus strand

Genomic View for EIF3F Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for EIF3F Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for EIF3F Gene

Regulatory Elements for EIF3F Gene

Proteins for EIF3F Gene

  • Protein details for EIF3F Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O00303-EIF3F_HUMAN
    Recommended name:
    Eukaryotic translation initiation factor 3 subunit F
    Protein Accession:
    O00303
    Secondary Accessions:
    • A8K0S2
    • Q6IB45
    • Q8N978

    Protein attributes for EIF3F Gene

    Size:
    357 amino acids
    Molecular mass:
    37564 Da
    Quaternary structure:
    • Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is composed of 13 subunits: EIF3A, EIF3B, EIF3C, EIF3D, EIF3E, EIF3F, EIF3G, EIF3H, EIF3I, EIF3J, EIF3K, EIF3L and EIF3M. The eIF-3 complex appears to include 3 stable modules: module A is composed of EIF3A, EIF3B, EIF3G and EIF3I; module B is composed of EIF3F, EIF3H, and EIF3M; and module C is composed of EIF3C, EIF3D, EIF3E, EIF3K and EIF3L. EIF3C of module C binds EIF3B of module A and EIF3H of module B, thereby linking the three modules. EIF3J is a labile subunit that binds to the eIF-3 complex via EIF3B. The eIF-3 complex interacts with RPS6KB1 under conditions of nutrient depletion. Mitogenic stimulation leads to binding and activation of a complex composed of MTOR and RPTOR, leading to phosphorylation and release of RPS6KB1 and binding of EIF4B to eIF-3. Interacts with RNF139; the interaction leads to protein translation inhibitions in a ubiquitination-dependent manner. Interacts with DTX1, the interaction is required for deubiquitinating activity towards NOTCH1.

    Three dimensional structures from OCA and Proteopedia for EIF3F Gene

neXtProt entry for EIF3F Gene

Proteomics data for EIF3F Gene at MOPED

Post-translational modifications for EIF3F Gene

  • Phosphorylation is enhanced upon serum stimulation. Phosphorylated during apoptosis by caspase-processed CDK11.
  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys162, Lys214, and Lys238

Other Protein References for EIF3F Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for EIF3F Gene

Domains for EIF3F Gene

Protein Domains for EIF3F Gene

InterPro:
Blocks:
ProtoNet:

UniProtKB/Swiss-Prot:

EIF3F_HUMAN
Domain:
  • The MPN domain mediates deubiquitinating activity:
    • O00303
  • Contains 1 MPN (JAB/Mov34) domain.:
    • O00303
Family:
  • Belongs to the eIF-3 subunit F family.:
    • O00303
genes like me logo Genes that share domains with EIF3F: view

No data available for Gene Families for EIF3F Gene

Function for EIF3F Gene

Molecular function for EIF3F Gene

UniProtKB/Swiss-Prot CatalyticActivity: Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).
UniProtKB/Swiss-Prot Function: Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S preinitiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation.
UniProtKB/Swiss-Prot Function: Deubiquitinates activated NOTCH1, promoting its nuclear import, thereby acting as a positive regulator of Notch signaling.

Enzyme Numbers (IUBMB) for EIF3F Gene

Gene Ontology (GO) - Molecular Function for EIF3F Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003743 translation initiation factor activity TAS 9341143
GO:0004843 ubiquitin-specific protease activity IDA 21124883
GO:0005515 protein binding IPI 16169070
GO:0031369 translation initiation factor binding --
genes like me logo Genes that share ontologies with EIF3F: view
genes like me logo Genes that share phenotypes with EIF3F: view

miRNA for EIF3F Gene

No data available for Animal Models , Transcription Factor Targeting and HOMER Transcription for EIF3F Gene

Localization for EIF3F Gene

Subcellular locations from UniProtKB/Swiss-Prot for EIF3F Gene

Cytoplasm.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for EIF3F Gene COMPARTMENTS Subcellular localization image for EIF3F gene
Compartment Confidence
cytosol 4
mitochondrion 2
extracellular 1
nucleus 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for EIF3F Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005829 cytosol TAS --
GO:0005852 eukaryotic translation initiation factor 3 complex TAS 9341143
GO:0016020 membrane IDA 19946888
GO:0016282 eukaryotic 43S preinitiation complex IEA --
GO:0033290 eukaryotic 48S preinitiation complex IEA --
genes like me logo Genes that share ontologies with EIF3F: view

Pathways for EIF3F Gene

genes like me logo Genes that share pathways with EIF3F: view

Pathways by source for EIF3F Gene

2 Qiagen pathways for EIF3F Gene
1 BioSystems pathway for EIF3F Gene

Gene Ontology (GO) - Biological Process for EIF3F Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001731 formation of translation preinitiation complex IEA --
GO:0006412 translation TAS --
GO:0006413 translational initiation TAS --
GO:0006446 regulation of translational initiation IEA --
GO:0006508 proteolysis --
genes like me logo Genes that share ontologies with EIF3F: view

Transcripts for EIF3F Gene

Unigene Clusters for EIF3F Gene

Eukaryotic translation initiation factor 3, subunit F:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for EIF3F Gene

No ASD Table

Relevant External Links for EIF3F Gene

GeneLoc Exon Structure for
EIF3F
ECgene alternative splicing isoforms for
EIF3F

Expression for EIF3F Gene

mRNA expression in normal human tissues for EIF3F Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for EIF3F Gene

SOURCE GeneReport for Unigene cluster for EIF3F Gene Hs.516023

genes like me logo Genes that share expressions with EIF3F: view

Orthologs for EIF3F Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for EIF3F Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia EIF3F 36
  • 98.99 (n)
  • 100 (a)
EIF3F 37
  • 98 (a)
OneToOne
cow
(Bos Taurus)
Mammalia EIF3F 36
  • 90.38 (n)
  • 97.99 (a)
EIF3F 37
  • 88 (a)
OneToOne
dog
(Canis familiaris)
Mammalia EIF3F 36
  • 87.33 (n)
  • 92.81 (a)
EIF3F 37
  • 96 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Eif3f 36
  • 88.7 (n)
  • 98.32 (a)
Eif3f 16
Eif3f 37
  • 91 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia EIF3F 37
  • 85 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia EIF3F 37
  • 94 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Eif3f 36
  • 87.36 (n)
  • 97.65 (a)
chicken
(Gallus gallus)
Aves EIF3F 36
  • 77.25 (n)
  • 89.19 (a)
EIF3F 37
  • 85 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia EIF3F 37
  • 85 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia eif3f 36
  • 75.59 (n)
  • 84.76 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.11217 36
zebrafish
(Danio rerio)
Actinopterygii Dr.5392 36
eif3f 36
  • 71.25 (n)
  • 80.3 (a)
eif3f 37
  • 77 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta EIF3F_ANOGA 36
  • 55.39 (n)
  • 51.84 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG8335 37
  • 35 (a)
OneToMany
CG9769 36
  • 55.76 (n)
  • 50 (a)
CG9769 37
  • 49 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea eif-3.F 36
  • 48.81 (n)
  • 38.11 (a)
eif-3.F 37
  • 35 (a)
OneToOne
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes RPN8 37
  • 22 (a)
OneToMany
thale cress
(Arabidopsis thaliana)
eudicotyledons EIF2 36
  • 49.94 (n)
  • 40.08 (a)
rice
(Oryza sativa)
Liliopsida Os05g0104800 36
  • 49.39 (n)
  • 39.78 (a)
bread mold
(Neurospora crassa)
Ascomycetes NCU01021 36
  • 46.26 (n)
  • 33.84 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes SPBC4C3.07 36
  • 46.61 (n)
  • 39.06 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.4777 36
sea squirt
(Ciona savignyi)
Ascidiacea CSA.5333 37
  • 51 (a)
OneToOne
Species with no ortholog for EIF3F:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for EIF3F Gene

ENSEMBL:
Gene Tree for EIF3F (if available)
TreeFam:
Gene Tree for EIF3F (if available)

Paralogs for EIF3F Gene

Paralogs for EIF3F Gene

Selected SIMAP similar genes for EIF3F Gene using alignment to 6 proteins:

Pseudogenes.org Pseudogenes for EIF3F Gene

genes like me logo Genes that share paralogs with EIF3F: view

Variants for EIF3F Gene

Sequence variations from dbSNP and Humsavar for EIF3F Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type MAF
rs1043738 - 7,987,468(-) CAGCG(A/G)GAACC reference, missense
rs1044058 - 7,992,163(-) CGTAC(A/C)AGCCC reference, missense
rs1105984 -- 7,995,183(-) AGCAC(A/G/T)TGCCT intron-variant
rs3892448 -- 7,992,591(+) AAAGG(A/G)AAGTG intron-variant
rs3903047 -- 7,992,565(+) GAGTG(A/C)GACCC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for EIF3F Gene

Variant ID Type Subtype PubMed ID
nsv7215 OTHER Inversion 18451855
nsv499766 OTHER Inversion 21111241

Relevant External Links for EIF3F Gene

HapMap Linkage Disequilibrium report
EIF3F

Disorders for EIF3F Gene

Relevant External Links for EIF3F

Genetic Association Database (GAD)
EIF3F
genes like me logo Genes that share disorders with EIF3F: view

No data available for UniProtKB/Swiss-Prot for EIF3F Gene

Publications for EIF3F Gene

  1. Structure of cDNAs encoding human eukaryotic initiation factor 3 subunits. Possible roles in RNA binding and macromolecular assembly. (PMID: 9341143) Asano K. … Hershey J.W.B. (J. Biol. Chem. 1997) 2 3 4
  2. Loss of the eukaryotic initiation factor 3f in pancreatic cancer. (PMID: 17918192) Doldan A. … Shi J. (Mol. Carcinog. 2008) 3 23
  3. Loss of the eukaryotic initiation factor 3f in melanoma. (PMID: 18381585) Doldan A. … Shi J. (Mol. Carcinog. 2008) 3 23
  4. The p34cdc2-related cyclin-dependent kinase 11 interacts with the p47 subunit of eukaryotic initiation factor 3 during apoptosis. (PMID: 12446680) Shi J. … Nelson M.A. (J. Biol. Chem. 2003) 3 4
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4

Products for EIF3F Gene

  • Addgene plasmids for EIF3F

Sources for EIF3F Gene

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