Aliases for EIF3F Gene
- Eukaryotic Translation Initiation Factor 3, Subunit F 2 3
- Eukaryotic Translation Initiation Factor 3, Subunit 5 Epsilon, 47kDa 2 3
- Deubiquitinating Enzyme EIF3f 3 4
- EIF-3-Epsilon 3 4
- EIF3S5 3 4
- Eukaryotic Translation Initiation Factor 3, Subunit 5 (Epsilon, 47kD) 3
- Eukaryotic Translation Initiation Factor 3 Subunit 5 4
External Ids for EIF3F Gene
Previous HGNC Symbols for EIF3F Gene
Previous GeneCards Identifiers for EIF3F Gene
GeneCards Summary for EIF3F Gene
EIF3F (Eukaryotic Translation Initiation Factor 3, Subunit F) is a Protein Coding gene. Among its related pathways are Apoptotic Pathways in Synovial Fibroblasts and p70S6K Signaling. GO annotations related to this gene include ubiquitin-specific protease activity and translation initiation factor binding. An important paralog of this gene is PSMD7.
UniProtKB/Swiss-Prot for EIF3F Gene
Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S preinitiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation.
Deubiquitinates activated NOTCH1, promoting its nuclear import, thereby acting as a positive regulator of Notch signaling.