Free for academic non-profit institutions. Other users need a Commercial license

Aliases for EIF3F Gene

Aliases for EIF3F Gene

  • Eukaryotic Translation Initiation Factor 3 Subunit F 2 3 5
  • Eukaryotic Translation Initiation Factor 3, Subunit 5 Epsilon, 47kDa 2 3
  • Deubiquitinating Enzyme EIF3f 3 4
  • EIF-3-Epsilon 3 4
  • EIF3S5 3 4
  • Eukaryotic Translation Initiation Factor 3, Subunit 5 (Epsilon, 47kD) 3
  • Eukaryotic Translation Initiation Factor 3, Subunit F 2
  • Eukaryotic Translation Initiation Factor 3 Subunit 5 4
  • EIF3-Epsilon 3
  • EC 3.4.19.12 4
  • EIF3-P47 3
  • EIF3 P47 4
  • EIF3f 4

External Ids for EIF3F Gene

Previous HGNC Symbols for EIF3F Gene

  • EIF3S5

Previous GeneCards Identifiers for EIF3F Gene

  • GC11P007675

Summaries for EIF3F Gene

GeneCards Summary for EIF3F Gene

EIF3F (Eukaryotic Translation Initiation Factor 3 Subunit F) is a Protein Coding gene. Among its related pathways are Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S and Apoptotic Pathways in Synovial Fibroblasts. GO annotations related to this gene include thiol-dependent ubiquitin-specific protease activity and translation initiation factor binding. An important paralog of this gene is EIF3FP2.

UniProtKB/Swiss-Prot for EIF3F Gene

  • Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis (PubMed:17581632, PubMed:25849773, PubMed:27462815). The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation (PubMed:17581632). The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, including cell cycling, differentiation and apoptosis, and uses different modes of RNA stem-loop binding to exert either translational activation or repression (PubMed:25849773).

  • Deubiquitinates activated NOTCH1, promoting its nuclear import, thereby acting as a positive regulator of Notch signaling.

Gene Wiki entry for EIF3F Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for EIF3F Gene

Genomics for EIF3F Gene

Regulatory Elements for EIF3F Gene

Enhancers for EIF3F Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH11F007985 0.2 ENCODE 43.9 +16.9 16938 2.7 PKNOX1 ARNT CREB3L1 WRNIP1 ARID4B SIN3A DMAP1 ZNF2 YY1 SLC30A9 EIF3F OLFML1 TMEM9B-AS1 ZNF214 SNORA3B CASC23 TUB COX6CP5 PIR63023
GH11F008681 0.2 ENCODE 30.2 +715.6 715605 8.7 HDGF PKNOX1 ARNT CREB3L1 MLX WRNIP1 ARID4B SIN3A DMAP1 ZNF2 TRIM66 EIF3F ENSG00000254397 TMEM9B-AS1 SNORA3B STK33 ZNF143 RPL27A WEE1 RPL21P97
GH11F007962 0.6 Ensembl ENCODE 29.1 -3.5 -3519 8.2 HDGF PKNOX1 ARNT CREB3L1 ZFP64 ARID4B SIN3A DMAP1 ZNF2 YY1 TMEM9B-AS1 EIF3F OLFML1 TUB ZNF214 NLRP10 OR10A3 AKIP1 CASC23 GC11M007966
GH11F008905 1.3 Ensembl ENCODE 15.8 +936.4 936422 3.3 TBP PKNOX1 INSM2 SIN3A BRCA1 RFX5 ZNF121 ZNF366 RCOR1 FOS TMEM9B-AS1 AKIP1 EIF3F SNORA3B WEE1 RPL21P97 ZNF143 ENSG00000223080 ASCL3 RPL27A
GH11F007676 0.8 ENCODE 12.3 -292.9 -292921 1.7 PKNOX1 FEZF1 ZIC2 ZNF843 ZNF518A ZFHX2 CTBP1 ZNF701 GLIS1 WT1 CYB5R2 EIF3F LOC100506258 LOC105376533 OVCH2 OLFML1 OR10AB1P ENSG00000275612
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around EIF3F on UCSC Golden Path with GeneCards custom track

Genomic Location for EIF3F Gene

Chromosome:
11
Start:
7,970,251 bp from pter
End:
8,001,862 bp from pter
Size:
31,612 bases
Orientation:
Plus strand

Genomic View for EIF3F Gene

Genes around EIF3F on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
EIF3F Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for EIF3F Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for EIF3F Gene

Proteins for EIF3F Gene

  • Protein details for EIF3F Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O00303-EIF3F_HUMAN
    Recommended name:
    Eukaryotic translation initiation factor 3 subunit F
    Protein Accession:
    O00303
    Secondary Accessions:
    • A8K0S2
    • Q6IB45
    • Q8N978

    Protein attributes for EIF3F Gene

    Size:
    357 amino acids
    Molecular mass:
    37564 Da
    Quaternary structure:
    • Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is composed of 13 subunits: EIF3A, EIF3B, EIF3C, EIF3D, EIF3E, EIF3F, EIF3G, EIF3H, EIF3I, EIF3J, EIF3K, EIF3L and EIF3M. The eIF-3 complex appears to include 3 stable modules: module A is composed of EIF3A, EIF3B, EIF3G and EIF3I; module B is composed of EIF3F, EIF3H, and EIF3M; and module C is composed of EIF3C, EIF3D, EIF3E, EIF3K and EIF3L. EIF3C of module C binds EIF3B of module A and EIF3H of module B, thereby linking the three modules. EIF3J is a labile subunit that binds to the eIF-3 complex via EIF3B. The eIF-3 complex interacts with RPS6KB1 under conditions of nutrient depletion. Mitogenic stimulation leads to binding and activation of a complex composed of MTOR and RPTOR, leading to phosphorylation and release of RPS6KB1 and binding of EIF4B to eIF-3. Interacts with RNF139; the interaction leads to protein translation inhibitions in a ubiquitination-dependent manner. Interacts with DTX1, the interaction is required for deubiquitinating activity towards NOTCH1.

    Three dimensional structures from OCA and Proteopedia for EIF3F Gene

neXtProt entry for EIF3F Gene

Post-translational modifications for EIF3F Gene

  • Phosphorylation is enhanced upon serum stimulation. Phosphorylated during apoptosis by caspase-processed CDK11.
  • Ubiquitination at Lys 162 and Lys 214
  • Modification sites at PhosphoSitePlus

Other Protein References for EIF3F Gene

No data available for DME Specific Peptides for EIF3F Gene

Domains & Families for EIF3F Gene

Gene Families for EIF3F Gene

Protein Domains for EIF3F Gene

Graphical View of Domain Structure for InterPro Entry

O00303

UniProtKB/Swiss-Prot:

EIF3F_HUMAN :
  • The MPN domain mediates deubiquitinating activity.
  • Belongs to the eIF-3 subunit F family.
Domain:
  • The MPN domain mediates deubiquitinating activity.
  • Contains 1 MPN (JAB/Mov34) domain.
Family:
  • Belongs to the eIF-3 subunit F family.
genes like me logo Genes that share domains with EIF3F: view

Function for EIF3F Gene

Molecular function for EIF3F Gene

UniProtKB/Swiss-Prot CatalyticActivity:
Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).
UniProtKB/Swiss-Prot Function:
Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis (PubMed:17581632, PubMed:25849773, PubMed:27462815). The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation (PubMed:17581632). The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, including cell cycling, differentiation and apoptosis, and uses different modes of RNA stem-loop binding to exert either translational activation or repression (PubMed:25849773).
UniProtKB/Swiss-Prot Function:
Deubiquitinates activated NOTCH1, promoting its nuclear import, thereby acting as a positive regulator of Notch signaling.

Enzyme Numbers (IUBMB) for EIF3F Gene

Gene Ontology (GO) - Molecular Function for EIF3F Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003743 translation initiation factor activity TAS 9341143
GO:0004843 thiol-dependent ubiquitin-specific protease activity IDA 21124883
GO:0005515 protein binding IPI 16169070
GO:0008233 peptidase activity IEA --
GO:0008234 cysteine-type peptidase activity IEA --
genes like me logo Genes that share ontologies with EIF3F: view
genes like me logo Genes that share phenotypes with EIF3F: view

Animal Model Products

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for EIF3F

Flow Cytometry Products

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for EIF3F Gene

Localization for EIF3F Gene

Subcellular locations from UniProtKB/Swiss-Prot for EIF3F Gene

Cytoplasm.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for EIF3F Gene COMPARTMENTS Subcellular localization image for EIF3F gene
Compartment Confidence
cytosol 5
mitochondrion 2
extracellular 1
nucleus 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for EIF3F Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
GO:0005829 cytosol TAS --
GO:0005852 eukaryotic translation initiation factor 3 complex TAS 9341143
GO:0016020 membrane IDA 19946888
GO:0016282 eukaryotic 43S preinitiation complex IEA --
genes like me logo Genes that share ontologies with EIF3F: view

Pathways & Interactions for EIF3F Gene

genes like me logo Genes that share pathways with EIF3F: view

SIGNOR curated interactions for EIF3F Gene

Activates:
Is inactivated by:
Other effect:

Gene Ontology (GO) - Biological Process for EIF3F Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006412 translation IEA --
GO:0006413 translational initiation IEA,TAS --
GO:0006446 regulation of translational initiation IEA --
GO:0006508 proteolysis IEA --
GO:0016579 protein deubiquitination IDA 21124883
genes like me logo Genes that share ontologies with EIF3F: view

Transcripts for EIF3F Gene

Unigene Clusters for EIF3F Gene

Eukaryotic translation initiation factor 3, subunit F:
Representative Sequences:

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for EIF3F

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for EIF3F Gene

No ASD Table

Relevant External Links for EIF3F Gene

GeneLoc Exon Structure for
EIF3F
ECgene alternative splicing isoforms for
EIF3F

Expression for EIF3F Gene

mRNA expression in normal human tissues for EIF3F Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for EIF3F Gene



Protein tissue co-expression partners for EIF3F Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of EIF3F Gene:

EIF3F

SOURCE GeneReport for Unigene cluster for EIF3F Gene:

Hs.516023
genes like me logo Genes that share expression patterns with EIF3F: view

Primer Products

No data available for mRNA differential expression in normal tissues , Protein differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for EIF3F Gene

Orthologs for EIF3F Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for EIF3F Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia EIF3F 34 35
  • 98.99 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia EIF3F 35
  • 94 (a)
OneToOne
cow
(Bos Taurus)
Mammalia EIF3F 34 35
  • 90.38 (n)
mouse
(Mus musculus)
Mammalia Eif3f 34 16 35
  • 88.7 (n)
rat
(Rattus norvegicus)
Mammalia Eif3f 34
  • 87.36 (n)
dog
(Canis familiaris)
Mammalia EIF3F 34 35
  • 87.33 (n)
oppossum
(Monodelphis domestica)
Mammalia EIF3F 35
  • 85 (a)
OneToOne
chicken
(Gallus gallus)
Aves EIF3F 34 35
  • 77.25 (n)
lizard
(Anolis carolinensis)
Reptilia EIF3F 35
  • 85 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia eif3f 34
  • 75.59 (n)
zebrafish
(Danio rerio)
Actinopterygii eif3f 34 35
  • 71.25 (n)
Dr.5392 34
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.11217 34
fruit fly
(Drosophila melanogaster)
Insecta CG9769 34 35
  • 55.76 (n)
CG8335 35
  • 35 (a)
OneToMany
African malaria mosquito
(Anopheles gambiae)
Insecta EIF3F_ANOGA 34
  • 55.39 (n)
worm
(Caenorhabditis elegans)
Secernentea eif-3.F 34 35
  • 48.81 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes RPN8 35
  • 22 (a)
OneToMany
thale cress
(Arabidopsis thaliana)
eudicotyledons EIF2 34
  • 49.94 (n)
rice
(Oryza sativa)
Liliopsida Os05g0104800 34
  • 49.39 (n)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.5333 35
  • 51 (a)
OneToOne
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes SPBC4C3.07 34
  • 46.61 (n)
bread mold
(Neurospora crassa)
Ascomycetes NCU01021 34
  • 46.26 (n)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.4777 34
Species where no ortholog for EIF3F was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for EIF3F Gene

ENSEMBL:
Gene Tree for EIF3F (if available)
TreeFam:
Gene Tree for EIF3F (if available)

Paralogs for EIF3F Gene

Paralogs for EIF3F Gene

(1) SIMAP similar genes for EIF3F Gene using alignment to 6 proteins:

Pseudogenes.org Pseudogenes for EIF3F Gene

genes like me logo Genes that share paralogs with EIF3F: view

Variants for EIF3F Gene

Sequence variations from dbSNP and Humsavar for EIF3F Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type
rs1043738 -- 7,987,468(-) CAGCG(A/G)GAACC reference, missense
rs1044058 -- 7,992,163(-) CGTAC(A/C)AGCCC reference, missense
rs10545177 -- 7,993,833(+) TCCAG(-/TA)TATAT intron-variant
rs10769861 -- 7,985,968(+) TTTTC(A/G)ATCTT upstream-variant-2KB
rs10839958 -- 7,990,737(+) GGTAG(A/T)TATAG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for EIF3F Gene

Variant ID Type Subtype PubMed ID
nsv499766 OTHER inversion 21111241
nsv7215 OTHER inversion 18451855

Variation tolerance for EIF3F Gene

Residual Variation Intolerance Score: 73.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.43; 63.98% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for EIF3F Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
EIF3F

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for EIF3F Gene

Disorders for EIF3F Gene

Relevant External Links for EIF3F

Genetic Association Database (GAD)
EIF3F
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
EIF3F

No disorders were found for EIF3F Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for EIF3F Gene

Publications for EIF3F Gene

  1. Structure of cDNAs encoding human eukaryotic initiation factor 3 subunits. Possible roles in RNA binding and macromolecular assembly. (PMID: 9341143) Asano K. … Hershey J.W.B. (J. Biol. Chem. 1997) 2 3 4 64
  2. eIF3 targets cell-proliferation messenger RNAs for translational activation or repression. (PMID: 25849773) Lee A.S. … Cate J.H. (Nature 2015) 3 4 64
  3. Genome-wide association scan of trait depression. (PMID: 20800221) Terracciano A. … Costa P.T. (Biol. Psychiatry 2010) 3 46 64
  4. The translation initiation factor 3f (eIF3f) exhibits a deubiquitinase activity regulating Notch activation. (PMID: 21124883) Moretti J. … Brou C. (PLoS Biol. 2010) 3 4 64
  5. Loss of the eukaryotic initiation factor 3f in melanoma. (PMID: 18381585) Doldan A. … Shi J. (Mol. Carcinog. 2008) 3 22 64

Products for EIF3F Gene

Sources for EIF3F Gene

Content
Loading form....