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EIF3F Gene

protein-coding   GIFtS: 58
GCID: GC11P007966

Eukaryotic Translation Initiation Factor 3, Subunit F

(Previous names: eukaryotic translation initiation factor 3, subunit 5 epsilon,...)
(Previous symbol: EIF3S5)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Eukaryotic Translation Initiation Factor 3, Subunit F1 2     Eukaryotic Translation Initiation Factor 3 Subunit F2
EIF3S51 2 3 5     Eukaryotic Translation Initiation Factor 3, Subunit 5 (Epsilon, 47kD)2
Eukaryotic Translation Initiation Factor 3, Subunit 5 Epsilon, 47kDa1 2     EC 3.4.19.123
Deubiquitinating Enzyme EIF3f2 3     eIF3f3
eIF-3-epsilon2 3     EIF3 P473
eIF3-epsilon2     Eukaryotic Translation Initiation Factor 3 Subunit 53
eIF3-p472     

External Ids:    HGNC: 32751   Entrez Gene: 86652   Ensembl: ENSG000001753907   OMIM: 6039145   UniProtKB: O003033   

Export aliases for EIF3F gene to outside databases

Previous GC identifer: GC11P007675


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for EIF3F Gene:
EIF3F (eukaryotic translation initiation factor 3, subunit F) is a protein-coding gene. Diseases associated with EIF3F include intrahepatic cholangiocarcinoma, and cholangiocarcinoma. GO annotations related to this gene include cysteine-type peptidase activity and translation initiation factor activity. An important paralog of this gene is PSMD7.

UniProtKB/Swiss-Prot: EIF3F_HUMAN, O00303
Function: Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for
several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and
facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S preinitiation
complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG
recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal
complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation
Function: Deubiquitinates activated NOTCH1, promoting its nuclear import, thereby acting as a positive regulator
of Notch signaling

Gene Wiki entry for EIF3F Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000011.10  NC_018922.2  NT_009237.19  
Regulatory elements:
   Regulatory transcription factor binding sites in the EIF3F gene promoter:
         GR   AML1a   Bach2   NRSF form 1   NRSF form 2   Arnt   Max   GR-alpha   ATF   c-Myc   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidEIF3F promoter sequence
   Search Chromatin IP Primers for EIF3F

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat EIF3F


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11p15.4   Ensembl cytogenetic band:  11p15.4   HGNC cytogenetic band: 11p15.4

EIF3F Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
EIF3F gene location

GeneLoc information about chromosome 11         GeneLoc Exon Structure

GeneLoc location for GC11P007966:  view genomic region     (about GC identifiers)

Start:
7,991,798 bp from pter      End:
8,023,409 bp from pter
Size:
31,612 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: EIF3F_HUMAN, O00303 (See protein sequence)
Recommended Name: Eukaryotic translation initiation factor 3 subunit F  
Size: 357 amino acids; 37564 Da
Subunit: Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is composed of 13
subunits: EIF3A, EIF3B, EIF3C, EIF3D, EIF3E, EIF3F, EIF3G, EIF3H, EIF3I, EIF3J, EIF3K, EIF3L and EIF3M. The eIF-3
complex appears to include 3 stable modules: module A is composed of EIF3A, EIF3B, EIF3G and EIF3I; module B is
composed of EIF3F, EIF3H, and EIF3M; and module C is composed of EIF3C, EIF3D, EIF3E, EIF3K and EIF3L. EIF3C of
module C binds EIF3B of module A and EIF3H of module B, thereby linking the three modules. EIF3J is a labile
subunit that binds to the eIF-3 complex via EIF3B. The eIF-3 complex interacts with RPS6KB1 under conditions of
nutrient depletion. Mitogenic stimulation leads to binding and activation of a complex composed of MTOR and
RPTOR, leading to phosphorylation and release of RPS6KB1 and binding of EIF4B to eIF-3. Interacts with RNF139;
the interaction leads to protein translation inhibitions in a ubiquitination-dependent manner. Interacts with
DTX1, the interaction is required for deubiquitinating activity towards NOTCH1
Mass spectrometry: Mass=37554.8; Method=Unknown; Range=1-357; Source=PubMed:17322308;
Mass spectrometry: Mass=37475.6; Mass_error=0.2; Method=MALDI; Range=1-357; Source=PubMed:18599441;
Secondary accessions: A8K0S2 Q6IB45 Q8N978

Explore the universe of human proteins at neXtProt for EIF3F: NX_O00303

Explore proteomics data for EIF3F at MOPED

Post-translational modifications: 

  • Phosphorylation is enhanced upon serum stimulation. Phosphorylated during apoptosis by caspase-processed CDK111
  • Ubiquitination2 at Lys162, Lys214, Lys238
  • Modification sites at PhosphoSitePlus

  • See EIF3F Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_003745.1  
    ENSEMBL proteins: 
     ENSP00000431800   ENSP00000432489   ENSP00000434286   ENSP00000442283   ENSP00000310040  
     ENSP00000396929  
    Reactome Protein details: O00303

    EIF3F Human Recombinant Protein Products:

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    3 InterPro protein domains:
     IPR000555 JAB_MPN_dom
     IPR027531 eIF3f
     IPR024969 Rpn11/EIF3F_C

    Graphical View of Domain Structure for InterPro Entry O00303

    ProtoNet protein and cluster: O00303

    1 Blocks protein domain: IPB000555 Mov34 family

    UniProtKB/Swiss-Prot: EIF3F_HUMAN, O00303
    Domain: The MPN domain mediates deubiquitinating activity
    Similarity: Belongs to the eIF-3 subunit F family
    Similarity: Contains 1 MPN (JAB/Mov34) domain


    EIF3F for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: EIF3F_HUMAN, O00303
    Function: Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for
    several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and
    facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S preinitiation
    complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG
    recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal
    complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation
    Function: Deubiquitinates activated NOTCH1, promoting its nuclear import, thereby acting as a positive regulator
    of Notch signaling
    Catalytic activity: Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by
    the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal)

         Enzyme Number (IUBMB): EC 3.4.19.121

         Gene Ontology (GO): 4 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003743translation initiation factor activity TAS9341143
    GO:0004843ubiquitin-specific protease activity IDA--
    GO:0005515protein binding IPI18354498
    GO:0008234cysteine-type peptidase activity ----
         
    EIF3F for ontologies           About GeneDecksing


    Phenotypes:
         5 GenomeRNAi human phenotypes for EIF3F:
     Decreased influenza A/WSN/33 r  Decreased viability of wild-ty  Increased S DNA content, incre  Increased cell death in HCC-19 
     Synthetic lethal with Ras 

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for EIF3F
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    miRNA
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    miRTarBase miRNAs that target EIF3F:
    hsa-mir-106b-5p (MIRT044355), hsa-mir-320a (MIRT044466), hsa-mir-16-5p (MIRT032018), hsa-mir-155-5p (MIRT021009)

    Block miRNA regulation of human, mouse, rat EIF3F using miScript Target Protectors
    1 qRT-PCR Assays for microRNA that regulate EIF3F:
    hsa-miR-4302
    SwitchGear 3'UTR luciferase reporter plasmidEIF3F 3' UTR sequence
    Inhib. RNA
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    Browse Sino Biological Human cDNA Clones
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for EIF3F


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    EIF3F_HUMAN, O00303: Cytoplasm (By similarity)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol4
    mitochondrion2
    extracellular1
    nucleus1
    peroxisome1

    Gene Ontology (GO): 4 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005829cytosol TAS--
    GO:0005852eukaryotic translation initiation factor 3 complex TAS9341143
    GO:0016282eukaryotic 43S preinitiation complex IEA--
    GO:0033290eukaryotic 48S preinitiation complex IEA--

    EIF3F for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for EIF3F About   (see all 6)                                                                                              See pathways by source

    SuperPathContained pathways About
    1Influenza Viral RNA Transcription and Replication
    L13a-mediated translational silencing of Ceruloplasmin expression0.94
    Cap-dependent Translation Initiation0.89
    Formation of a pool of free 40S subunits0.94
    Eukaryotic Translation Initiation0.89
    GTP hydrolysis and joining of the 60S ribosomal subunit0.93
    Translation0.82
    2Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S
    Translation initiation complex formation0.91
    Formation of the ternary complex, and subsequently, the 43S complex0.91
    Ribosomal scanning and start codon recognition0.91
    Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S0.90
    3Gene Expression
    Gene Expression0.40
    4Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein
    Metabolism of proteins0.30
    5Translation Factors
    Translation Factors

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    2 Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for EIF3F
        eIF2 Pathway
    mTOR Pathway

    1 BioSystems Pathway for EIF3F
        Translation Factors

    Selected Reactome Pathways for EIF3F (see all 6)
        Formation of the ternary complex, and subsequently, the 43S complex
    L13a-mediated translational silencing of Ceruloplasmin expression
    GTP hydrolysis and joining of the 60S ribosomal subunit
    Ribosomal scanning and start codon recognition
    Formation of a pool of free 40S subunits


    1 Kegg Pathway  (Kegg details for EIF3F):
        RNA transport


    EIF3F for pathways           About GeneDecksing

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for EIF3F
    Interactions:

        Search GeneGlobe Interaction Network for EIF3F

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for EIF3F (O003031, 2, 3 ENSP000003100404) via UniProtKB, MINT, STRING, and/or I2D (see all 191)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    FBXO32Q969P51, 2, 3EBI-711990,EBI-2932534 MINT-6613268 MINT-6613284 MINT-6613316 MINT-6613441 MINT-6613301 MINT-6613335 MINT-6613420 I2D: score=3 
    EIF3BP558841, 2, 3, ENSP000003541254EBI-711990,EBI-366696 MINT-6948891 MINT-6948874 I2D: score=2 STRING: ENSP00000354125
    CDK11BP211271, 2, 3EBI-711990,EBI-1298 MINT-6948862 MINT-6948836 MINT-6948849 I2D: score=1 
    HAX1O001652, 3, ENSP000003290024MINT-67833 I2D: score=5 STRING: ENSP00000329002
    EIF3CQ996132, 3, ENSP000003326044MINT-6948891 I2D: score=1 STRING: ENSP00000332604
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    Gene Ontology (GO): Selected biological process terms (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001731formation of translation preinitiation complex IEA--
    GO:0006412translation TAS--
    GO:0006413translational initiation TAS--
    GO:0006446regulation of translational initiation IEA--
    GO:0006508proteolysis ----

    EIF3F for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for EIF3F



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for EIF3F gene: 
    NM_003754.2  

    Unigene Cluster for EIF3F:

    Eukaryotic translation initiation factor 3, subunit F
    Hs.516023  [show with all ESTs]
    Unigene Representative Sequence: AK095574
    10 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000533626(uc001mfw.3 uc010rbj.2) ENST00000531329 ENST00000528653
    ENST00000532882 ENST00000530219 ENST00000528763 ENST00000531572 ENST00000537635
    ENST00000309828 ENST00000449102
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    SwitchGear 3'UTR luciferase reporter plasmidEIF3F 3' UTR sequence
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      QuantiTect SYBR Green Assays in human, mouse, rat EIF3F
      QuantiFast Probe-based Assays in human, mouse, rat EIF3F

    Additional mRNA sequence: 

    AK057956.1 AK093511.1 AK095574.1 AK289637.1 AK291354.1 AK293826.1 AK297621.1 BC000490.2 
    BC073753.1 BT006894.1 CR456959.1 U94855.1 

    Selected DOTS entries (see all 26):

    DT.100888003  DT.100887999  DT.91820308  DT.87014914  DT.92412921  DT.97860781  DT.120717802  DT.100045056 
    DT.100887996  DT.120479  DT.120717817  DT.100888001  DT.91754000  DT.100888000  DT.100888005  DT.95107299 
    DT.97860782  DT.100888002  DT.100888009  DT.111212  DT.120717793  DT.120717799  DT.120717805  DT.40107300 

    Selected AceView cDNA sequences (see all 1095):

    CB141283 BP340680 AA723181 BG755589 AA541580 T35840 AA485502 AI833269 
    AA628666 AI754444 CA418811 CA306790 BQ064113 BU789648 BU729593 T35826 
    CB321719 AA622395 N44124 BQ271782 AW246593 BQ189588 AK095574 BE274579 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    EIF3F expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CTCAACAGCA
    EIF3F Expression
    About this image

    EIF3F Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    EIF3F Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.516023
        Custom PCR Arrays for EIF3F
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for EIF3F

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of eukaryotes.

    Orthologs for EIF3F gene from Selected species (see all 22)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Eif3f1 , 5 eukaryotic translation initiation factor 3, subunit more1, 5 88.7(n)1
    98.32(a)1
      7 (57.21 cM)5
    660851  NM_025344.21  NP_079620.21 
     1089344175 
    chicken
    (Gallus gallus)
    Aves EIF3F1 eukaryotic translation initiation factor 3, subunit more 77.25(n)
    89.19(a)
      423748  XM_421624.4  XP_421624.1 
    lizard
    (Anolis carolinensis)
    Reptilia EIF3F6
    eukaryotic translation initiation factor 3, subuni...
    85(a)
    1 ↔ 1
    GL343196.1(811784-822734)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia eif3f1 eukaryotic translation initiation factor 3, subunit more 75.59(n)
    84.76(a)
      548944  NM_001016190.2  NP_001016190.1 
    zebrafish
    (Danio rerio)
    Actinopterygii Dr.53922 Transcribed sequence with moderate similarity to protein more 78.92(n)    CK238649.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG97691 CG9769 55.76(n)
    50(a)
      40587  NM_141232.3  NP_649489.1 
    worm
    (Caenorhabditis elegans)
    Secernentea eif-3.F1 eif-3.F 48.81(n)
    38.11(a)
      174478  NM_063587.6  NP_495988.1 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes RPN86
    Essential, non-ATPase regulatory subunit of the 26...
    22(a)
    1 → many
    XV(815915-816931) YOR261C
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons EIF21 EIF2 49.94(n)
    40.08(a)
      818587  NM_129557.3  NP_181528.1 
    rice
    (Oryza sativa)
    Liliopsida Os05g01048001 Os05g0104800 49.39(n)
    39.78(a)
      4337552  NM_001060940.1  NP_001054405.1 


    ENSEMBL Gene Tree for EIF3F (if available)
    TreeFam Gene Tree for EIF3F (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for EIF3F gene
    PSMD72  COPS62  
    1 SIMAP similar gene for EIF3F using alignment to 6 protein entries:     EIF3F_HUMAN (see all proteins):
    IFP38

    EIF3F for paralogs           About GeneDecksing


    3 Pseudogenes.org Pseudogenes for EIF3F
    PGOHUM00000250981 PGOHUM00000259651 PGOHUM00000259652


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for EIF3F (see all 331)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 11 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1924915131,2
    --8007044(+) ATGATC/GTCAAT 1 -- us2k10--------
    rs1380088761,2
    C--8007101(+) GGCCA-/GGGGGCC 1 -- us2k10--------
    rs783377581,2
    F--8007195(+) TTAGAT/CATTTT 1 -- us2k11Minor allele frequency- C:0.07WA 118
    rs1396208271,2
    --8007491(+) CAGGTA/CATCAA 1 -- us2k10--------
    rs107698611,2
    C,F,A,H--8007515(+) TTTTCG/AATCTT 1 -- us2k1 tfbs325Minor allele frequency- A:0.20NS EA NA WA CSA 2356
    rs792275001,2
    C,F--8007593(+) GGGGAG/ACAGCG 1 -- us2k12Minor allele frequency- A:0.12NA EA 240
    rs1119741731,2
    C,F--8007637(+) AGGAGT/AAATCA 1 -- us2k11Minor allele frequency- A:0.50NA 2
    rs1889956691,2
    --8007721(+) ACCTAA/GTTAAG 1 -- us2k10--------
    rs760201261,2
    F--8007748(+) TTGGTG/ATTTTG 1 -- us2k11Minor allele frequency- A:0.07WA 118
    rs1434093901,2
    --8007781(+) TATCAC/TCCCAT 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for EIF3F (7991798 - 8023409 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for EIF3F:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv499766OTHER Inversion21111241
    nsv7215OTHER Inversion18451855

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing EIF3F
    DNA2.0 Custom Variant and Variant Library Synthesis for EIF3F

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 603914    OMIM disorders: --

    8 diseases for EIF3F:    About MalaCards
    intrahepatic cholangiocarcinoma    cholangiocarcinoma    hiv-1    pancreatic cancer
    pancreatitis    melanoma    malaria    prostatitis


    EIF3F for disorders           About GeneDecksing

    Genetic Association Database (GAD): EIF3F

    Export disorders for EIF3F gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for EIF3F gene, integrated from 10 sources (see all 68):
    (articles sorted by number of sources associating them with EIF3F)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Structure of cDNAs encoding human eukaryotic initiation factor 3 subunits. Possible roles in RNA binding and macromolecular assembly. (PubMed id 9341143)1, 2, 3 Asano K.... Hershey J.W.B. (J. Biol. Chem. 1997)
    2. The translation initiation factor 3f (eIF3f) exhibits a deubiquitinase activity regulating Notch activation. (PubMed id 21124883)1, 2 Moretti J.... Brou C. (PLoS Biol. 2010)
    3. Genome-wide association scan of trait depression. (PubMed id 20800221)1, 4 Terracciano A....Costa P.T. (Biol. Psychiatry 2010)
    4. Mass spectrometry reveals modularity and a complete subunit interaction map of the eukaryotic translation factor eIF3. (PubMed id 18599441)1, 2 Zhou M.... Robinson C.V. (Proc. Natl. Acad. Sci. U.S.A. 2008)
    5. Reconstitution reveals the functional core of mammalian eIF3. (PubMed id 17581632)1, 2 Masutani M.... Imataka H. (EMBO J. 2007)
    6. Structural characterization of the human eukaryotic initiation factor 3 protein complex by mass spectrometry. (PubMed id 17322308)1, 2 Damoc E.... Leary J.A. (Mol. Cell. Proteomics 2007)
    7. mTOR and S6K1 mediate assembly of the translation preinitiation complex through dynamic protein interchange and ordered phosphorylation events. (PubMed id 16286006)1, 2 Holz M.K.... Blenis J. (Cell 2005)
    8. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    9. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    10. The p34cdc2-related cyclin-dependent kinase 11 interacts with the p47 subunit of eukaryotic initiation factor 3 during apoptosis. (PubMed id 12446680)1, 2 Shi J.... Nelson M.A. (J. Biol. Chem. 2003)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 8665 HGNC: 3275 AceView: EIF3S5 Ensembl:ENSG00000175390 euGenes: HUgn8665
    ECgene: EIF3F Kegg: 8665 H-InvDB: EIF3F

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for EIF3F Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for EIF3F Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for EIF3F gene:
    Search GeneIP for patents involving EIF3F

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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