Aliases for EIF3E Gene
- Eukaryotic Translation Initiation Factor 3 Subunit E 2 3 5
- Eukaryotic Translation Initiation Factor 3, Subunit 6 48kDa 2 3
- Eukaryotic Translation Initiation Factor 3 Subunit 6 3 4
- Viral Integration Site Protein INT-6 Homolog 3 4
- EIF-3 P48 3 4
- EIF3S6 3 4
- INT6 3 4
- Eukaryotic Translation Initiation Factor 3 Subunit E Isoform 2 Transcript 3
External Ids for EIF3E Gene
Previous HGNC Symbols for EIF3E Gene
Previous GeneCards Identifiers for EIF3E Gene
GeneCards Summary for EIF3E Gene
EIF3E (Eukaryotic Translation Initiation Factor 3 Subunit E) is a Protein Coding gene. Among its related pathways are Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S and Apoptotic Pathways in Synovial Fibroblasts. GO annotations related to this gene include poly(A) RNA binding and translation initiation factor activity.
UniProtKB/Swiss-Prot for EIF3E Gene
Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis (PubMed:17581632, PubMed:25849773, PubMed:27462815). The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation (PubMed:17581632). The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, including cell cycling, differentiation and apoptosis, and uses different modes of RNA stem-loop binding to exert either translational activation or repression (PubMed:25849773). Required for nonsense-mediated mRNA decay (NMD); may act in conjunction with UPF2 to divert mRNAs from translation to the NMD pathway (PubMed:17468741). May interact with MCM7 and EPAS1 and regulate the proteasome-mediated degradation of these proteins (PubMed:17310990, PubMed:17324924).