Free for academic non-profit institutions. Other users need a Commercial license

Aliases for EIF3E Gene

Aliases for EIF3E Gene

  • Eukaryotic Translation Initiation Factor 3 Subunit E 2 3 5
  • Eukaryotic Translation Initiation Factor 3, Subunit 6 48kDa 2 3
  • Eukaryotic Translation Initiation Factor 3, Subunit E 2 3
  • Eukaryotic Translation Initiation Factor 3 Subunit 6 3 4
  • Viral Integration Site Protein INT-6 Homolog 3 4
  • EIF-3 P48 3 4
  • EIF3S6 3 4
  • INT6 3 4
  • Eukaryotic Translation Initiation Factor 3, Subunit 6 (48kD) 3
  • Murine Mammary Tumor Integration Site 6 (Oncogene Homolog) 3
  • Mammary Tumor-Associated Protein INT6 3
  • EIF3-P48 3
  • EIF3-P46 3
  • EIF3e 4

External Ids for EIF3E Gene

Previous HGNC Symbols for EIF3E Gene

  • INT6
  • EIF3S6

Previous GeneCards Identifiers for EIF3E Gene

  • GC08M109284
  • GC08M104535
  • GC08M109215

Summaries for EIF3E Gene

GeneCards Summary for EIF3E Gene

EIF3E (Eukaryotic Translation Initiation Factor 3 Subunit E) is a Protein Coding gene. Among its related pathways are Gene Expression and Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S. GO annotations related to this gene include poly(A) RNA binding and translation initiation factor activity.

UniProtKB/Swiss-Prot for EIF3E Gene

  • Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S preinitiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation. Required for nonsense-mediated mRNA decay (NMD); may act in conjunction with UPF2 to divert mRNAs from translation to the NMD pathway. May interact with MCM7 and EPAS1 and regulate the proteasome-mediated degradation of these proteins.

Gene Wiki entry for EIF3E Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for EIF3E Gene

Genomics for EIF3E Gene

Regulatory Elements for EIF3E Gene

Enhancers for EIF3E Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around EIF3E on UCSC Golden Path with GeneCards custom track

Genomic Location for EIF3E Gene

Chromosome:
8
Start:
108,201,216 bp from pter
End:
108,435,333 bp from pter
Size:
234,118 bases
Orientation:
Minus strand

Genomic View for EIF3E Gene

Genes around EIF3E on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
EIF3E Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for EIF3E Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for EIF3E Gene

Proteins for EIF3E Gene

  • Protein details for EIF3E Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P60228-EIF3E_HUMAN
    Recommended name:
    Eukaryotic translation initiation factor 3 subunit E
    Protein Accession:
    P60228
    Secondary Accessions:
    • O43902
    • Q64058
    • Q64059
    • Q64252
    • Q6FG33
    • Q8WVK4

    Protein attributes for EIF3E Gene

    Size:
    445 amino acids
    Molecular mass:
    52221 Da
    Quaternary structure:
    • Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is composed of 13 subunits: EIF3A, EIF3B, EIF3C, EIF3D, EIF3E, EIF3F, EIF3G, EIF3H, EIF3I, EIF3J, EIF3K, EIF3L and EIF3M. The eIF-3 complex appears to include 3 stable modules: module A is composed of EIF3A, EIF3B, EIF3G and EIF3I; module B is composed of EIF3F, EIF3H, and EIF3M; and module C is composed of EIF3C, EIF3D, EIF3E, EIF3K and EIF3L. EIF3C of module C binds EIF3B of module A and EIF3H of module B, thereby linking the three modules. EIF3J is a labile subunit that binds to the eIF-3 complex via EIF3B. The eIF-3 complex interacts with RPS6KB1 under conditions of nutrient depletion. Mitogenic stimulation leads to binding and activation of a complex composed of MTOR and RPTOR, leading to phosphorylation and release of RPS6KB1 and binding of EIF4B to eIF-3. Interacts with COPS3, COPS6, COPS7 (COPS7A or COPS7B), EIF4G1, EPAS1, MCM7, NCBP1, PSMC6, TRIM27 and UPF2. Interacts with the HTLV-1 protein Tax-1. Interacts with IFIT1 and IFIT2.

    Three dimensional structures from OCA and Proteopedia for EIF3E Gene

neXtProt entry for EIF3E Gene

Proteomics data for EIF3E Gene at MOPED

Post-translational modifications for EIF3E Gene

  • Ubiquitination at Lys 82, Lys 93, Lys 265, Lys 387, Lys 407, Lys 424, and Lys 425
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for EIF3E Gene

Domains & Families for EIF3E Gene

Gene Families for EIF3E Gene

Protein Domains for EIF3E Gene

Graphical View of Domain Structure for InterPro Entry

P60228

UniProtKB/Swiss-Prot:

EIF3E_HUMAN :
  • Contains 1 PCI domain.
  • Belongs to the eIF-3 subunit E family.
Domain:
  • Contains 1 PCI domain.
Family:
  • Belongs to the eIF-3 subunit E family.
genes like me logo Genes that share domains with EIF3E: view

Function for EIF3E Gene

Molecular function for EIF3E Gene

UniProtKB/Swiss-Prot Function:
Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S preinitiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation. Required for nonsense-mediated mRNA decay (NMD); may act in conjunction with UPF2 to divert mRNAs from translation to the NMD pathway. May interact with MCM7 and EPAS1 and regulate the proteasome-mediated degradation of these proteins.

Gene Ontology (GO) - Molecular Function for EIF3E Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IEA,IPI 10504338
genes like me logo Genes that share ontologies with EIF3E: view
genes like me logo Genes that share phenotypes with EIF3E: view

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for EIF3E Gene

Localization for EIF3E Gene

Subcellular locations from UniProtKB/Swiss-Prot for EIF3E Gene

Cytoplasm. Nucleus, PML body.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for EIF3E Gene COMPARTMENTS Subcellular localization image for EIF3E gene
Compartment Confidence
cytosol 5
extracellular 5
nucleus 5
mitochondrion 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for EIF3E Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000785 colocalizes_with chromatin NAS 17468741
GO:0005829 cytosol TAS --
GO:0016020 membrane IDA 19946888
GO:0016605 colocalizes_with PML body IEA,IDA 10504338
GO:0033290 eukaryotic 48S preinitiation complex IEA --
genes like me logo Genes that share ontologies with EIF3E: view

Pathways & Interactions for EIF3E Gene

genes like me logo Genes that share pathways with EIF3E: view

Gene Ontology (GO) - Biological Process for EIF3E Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000184 nuclear-transcribed mRNA catabolic process, nonsense-mediated decay IMP 17468741
GO:0006413 translational initiation IEA,TAS --
GO:0006446 regulation of translational initiation IEA,NAS 9295280
GO:0044267 cellular protein metabolic process TAS --
genes like me logo Genes that share ontologies with EIF3E: view

No data available for SIGNOR curated interactions for EIF3E Gene

Drugs & Compounds for EIF3E Gene

No Compound Related Data Available

Transcripts for EIF3E Gene

Unigene Clusters for EIF3E Gene

Eukaryotic translation initiation factor 3, subunit E:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for EIF3E Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6
SP1: -
SP2:
SP3:

Relevant External Links for EIF3E Gene

GeneLoc Exon Structure for
EIF3E
ECgene alternative splicing isoforms for
EIF3E

Expression for EIF3E Gene

mRNA expression in normal human tissues for EIF3E Gene

Protein differential expression in normal tissues from HIPED for EIF3E Gene

This gene is overexpressed in Bone (7.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for EIF3E Gene



SOURCE GeneReport for Unigene cluster for EIF3E Gene Hs.405590

mRNA Expression by UniProt/SwissProt for EIF3E Gene

P60228-EIF3E_HUMAN
Tissue specificity: Ubiquitously expressed. Expressed at highest levels in appendix, lymph, pancreas, skeletal muscle, spleen and thymus.
genes like me logo Genes that share expression patterns with EIF3E: view

Protein tissue co-expression partners for EIF3E Gene

- Elite partner

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for EIF3E Gene

Orthologs for EIF3E Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for EIF3E Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia EIF3E 35
  • 94.38 (n)
  • 99.78 (a)
EIF3E 36
  • 100 (a)
OneToOne
dog
(Canis familiaris)
Mammalia EIF3E 35
  • 94.61 (n)
  • 100 (a)
EIF3E 36
  • 100 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Eif3e 35
  • 90.79 (n)
  • 100 (a)
Eif3e 16
Eif3e 36
  • 100 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia EIF3E 35
  • 98.13 (n)
  • 97.97 (a)
EIF3E 36
  • 98 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Eif3e 35
  • 91.24 (n)
  • 100 (a)
oppossum
(Monodelphis domestica)
Mammalia EIF3E 36
  • 96 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia EIF3E 36
  • 100 (a)
OneToOne
chicken
(Gallus gallus)
Aves EIF3E 35
  • 84.27 (n)
  • 97.53 (a)
EIF3E 36
  • 98 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia EIF3E 36
  • 97 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia eif3e 35
  • 81.65 (n)
  • 96.63 (a)
MGC76151 35
African clawed frog
(Xenopus laevis)
Amphibia LOC398503 35
zebrafish
(Danio rerio)
Actinopterygii Dr.5119 35
eif3ea 35
  • 76.78 (n)
  • 93.48 (a)
eif3ea 36
  • 93 (a)
OneToOne
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.10728 35
African malaria mosquito
(Anopheles gambiae)
Insecta EIF3E_ANOGA 35
  • 58.41 (n)
  • 60.1 (a)
fruit fly
(Drosophila melanogaster)
Insecta Int6 35
  • 59.15 (n)
  • 60.93 (a)
Int6 36
  • 60 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea eif-3.E 35
  • 55.13 (n)
  • 51.31 (a)
eif-3.E 36
  • 50 (a)
OneToOne
thale cress
(Arabidopsis thaliana)
eudicotyledons EIF3E 35
  • 57.38 (n)
  • 55.99 (a)
Alicante grape
(Vitis vinifera)
eudicotyledons Vvi.5027 35
rice
(Oryza sativa)
Liliopsida Os.6714 35
Os07g0167000 35
  • 60.68 (n)
  • 59.52 (a)
wheat
(Triticum aestivum)
Liliopsida Ta.2821 35
corn
(Zea mays)
Liliopsida Zm.15445 35
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.2199 35
bread mold
(Neurospora crassa)
Ascomycetes NCU05889 35
  • 50 (n)
  • 44.5 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes int6 35
  • 52.22 (n)
  • 45.71 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.11027 36
  • 65 (a)
OneToOne
Species with no ortholog for EIF3E:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)

Evolution for EIF3E Gene

ENSEMBL:
Gene Tree for EIF3E (if available)
TreeFam:
Gene Tree for EIF3E (if available)

Paralogs for EIF3E Gene

genes like me logo Genes that share paralogs with EIF3E: view

No data available for Paralogs for EIF3E Gene

Variants for EIF3E Gene

Sequence variations from dbSNP and Humsavar for EIF3E Gene

SNP ID Clin Chr 08 pos Sequence Context AA Info Type
rs17856554 - 108,229,113(+) CCATG(A/G)CTGCA reference, missense
rs2045401 -- 108,247,950(-) TTGGT(C/T)GTTAA intron-variant
rs2276142 -- 108,214,843(+) TTCTA(C/G)AACAC intron-variant
rs2348753 -- 108,223,992(+) gtggg(C/T)gggtc intron-variant
rs7838657 -- 108,239,756(+) TTTTT(A/T)AGGAA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for EIF3E Gene

Variant ID Type Subtype PubMed ID
esv24969 CNV Loss 19812545
esv2677243 CNV Deletion 23128226
esv2667842 CNV Deletion 23128226

Variation tolerance for EIF3E Gene

Residual Variation Intolerance Score: 21.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.49; 10.57% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for EIF3E Gene

Human Gene Mutation Database (HGMD)
EIF3E

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for EIF3E Gene

Disorders for EIF3E Gene

Relevant External Links for EIF3E

Genetic Association Database (GAD)
EIF3E
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
EIF3E

No disorders were found for EIF3E Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for EIF3E Gene

Publications for EIF3E Gene

  1. The translation initiation factor eIF3-p48 subunit is encoded by int- 6, a site of frequent integration by the mouse mammary tumor virus genome. (PMID: 9295280) Asano K. … Hershey J.W.B. (J. Biol. Chem. 1997) 2 3 4 23 67
  2. Human INT6/eIF3e is required for nonsense-mediated mRNA decay. (PMID: 17468741) Morris C. … Jalinot P. (EMBO Rep. 2007) 3 23
  3. Translation initiation factor eIF4G-1 binds to eIF3 through the eIF3e subunit. (PMID: 16766523) LeFebvre A.K. … Rhoads R.E. (J. Biol. Chem. 2006) 3 23
  4. Int6 expression can predict survival in early-stage non-small cell lung cancer patients. (PMID: 15867213) Buttitta F. … Marchetti A. (Clin. Cancer Res. 2005) 3 23
  5. Cell cycle-related variation in subcellular localization of eIF3e/INT6 in human fibroblasts. (PMID: 15030549) Watkins S.J. … Norbury C.J. (Cell Prolif. 2004) 3 23

Products for EIF3E Gene

Sources for EIF3E Gene

Content