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Aliases for EIF3E Gene

Aliases for EIF3E Gene

  • Eukaryotic Translation Initiation Factor 3, Subunit E 2 3
  • EIF3S6 3 4 6
  • INT6 3 4 6
  • Eukaryotic Translation Initiation Factor 3, Subunit 6 48kDa 2 3
  • Eukaryotic Translation Initiation Factor 3 Subunit 6 3 4
  • Viral Integration Site Protein INT-6 Homolog 3 4
  • EIF-3 P48 3 4
  • Eukaryotic Translation Initiation Factor 3, Subunit 6 (48kD) 3
  • Murine Mammary Tumor Integration Site 6 (Oncogene Homolog) 3
  • Eukaryotic Translation Initiation Factor 3 Subunit E 3
  • Mammary Tumor-Associated Protein INT6 3
  • EIF3-P48 3
  • EIF3-P46 3
  • EIF3e 4

External Ids for EIF3E Gene

Previous Symbols for EIF3E Gene

  • INT6
  • EIF3S6

Summaries for EIF3E Gene

GeneCards Summary for EIF3E Gene

EIF3E (Eukaryotic Translation Initiation Factor 3, Subunit E) is a Protein Coding gene. Among its related pathways are p70S6K Signaling and Apoptotic Pathways in Synovial Fibroblasts. GO annotations related to this gene include protein N-terminus binding and translation initiation factor activity.

UniProtKB/Swiss-Prot for EIF3E Gene

  • Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S preinitiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation. Required for nonsense-mediated mRNA decay (NMD); may act in conjunction with UPF2 to divert mRNAs from translation to the NMD pathway. May interact with MCM7 and EPAS1 and regulate the proteasome-mediated degradation of these proteins.

Gene Wiki entry for EIF3E Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for EIF3E Gene

Genomics for EIF3E Gene

Genomic Location for EIF3E Gene

Start:
108,201,216 bp from pter
End:
108,435,333 bp from pter
Size:
234,118 bases
Orientation:
Minus strand

Genomic View for EIF3E Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for EIF3E Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for EIF3E Gene

Regulatory Elements for EIF3E Gene

Proteins for EIF3E Gene

  • Protein details for EIF3E Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P60228-EIF3E_HUMAN
    Recommended name:
    Eukaryotic translation initiation factor 3 subunit E
    Protein Accession:
    P60228
    Secondary Accessions:
    • O43902
    • Q64058
    • Q64059
    • Q64252
    • Q6FG33
    • Q8WVK4

    Protein attributes for EIF3E Gene

    Size:
    445 amino acids
    Molecular mass:
    52221 Da
    Quaternary structure:
    • Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is composed of 13 subunits: EIF3A, EIF3B, EIF3C, EIF3D, EIF3E, EIF3F, EIF3G, EIF3H, EIF3I, EIF3J, EIF3K, EIF3L and EIF3M. The eIF-3 complex appears to include 3 stable modules: module A is composed of EIF3A, EIF3B, EIF3G and EIF3I; module B is composed of EIF3F, EIF3H, and EIF3M; and module C is composed of EIF3C, EIF3D, EIF3E, EIF3K and EIF3L. EIF3C of module C binds EIF3B of module A and EIF3H of module B, thereby linking the three modules. EIF3J is a labile subunit that binds to the eIF-3 complex via EIF3B. The eIF-3 complex interacts with RPS6KB1 under conditions of nutrient depletion. Mitogenic stimulation leads to binding and activation of a complex composed of MTOR and RPTOR, leading to phosphorylation and release of RPS6KB1 and binding of EIF4B to eIF-3. Interacts with COPS3, COPS6, COPS7 (COPS7A or COPS7B), EIF4G1, EPAS1, MCM7, NCBP1, PSMC6, TRIM27 and UPF2. Interacts with the HTLV-1 protein Tax-1. Interacts with IFIT1 and IFIT2.

    Three dimensional structures from OCA and Proteopedia for EIF3E Gene

neXtProt entry for EIF3E Gene

Proteomics data for EIF3E Gene at MOPED

Post-translational modifications for EIF3E Gene

  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys82, Lys93, Lys265, Lys387, Lys407, Lys409, Lys424, and Lys425

Other Protein References for EIF3E Gene

No data available for DME Specific Peptides for EIF3E Gene

Domains for EIF3E Gene

Protein Domains for EIF3E Gene

Suggested Antigen Peptide Sequences for EIF3E Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P60228

UniProtKB/Swiss-Prot:

EIF3E_HUMAN
Domain:
  • Contains 1 PCI domain.:
    • P60228
Family:
  • Belongs to the eIF-3 subunit E family.:
    • P60228
genes like me logo Genes that share domains with EIF3E: view

No data available for Gene Families for EIF3E Gene

Function for EIF3E Gene

Molecular function for EIF3E Gene

UniProtKB/Swiss-Prot Function: Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S preinitiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation. Required for nonsense-mediated mRNA decay (NMD); may act in conjunction with UPF2 to divert mRNAs from translation to the NMD pathway. May interact with MCM7 and EPAS1 and regulate the proteasome-mediated degradation of these proteins.

Gene Ontology (GO) - Molecular Function for EIF3E Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003743 contributes_to translation initiation factor activity IDA 17581632
GO:0005515 protein binding IPI 10504338
GO:0044822 poly(A) RNA binding IDA 22681889
GO:0047485 protein N-terminus binding IPI 10504338
genes like me logo Genes that share ontologies with EIF3E: view
genes like me logo Genes that share phenotypes with EIF3E: view

miRNA for EIF3E Gene

miRTarBase miRNAs that target EIF3E

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for EIF3E Gene

Localization for EIF3E Gene

Subcellular locations from UniProtKB/Swiss-Prot for EIF3E Gene

Cytoplasm. Nucleus, PML body.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for EIF3E Gene COMPARTMENTS Subcellular localization image for EIF3E gene
Compartment Confidence
nucleus 5
cytosol 4
mitochondrion 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for EIF3E Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000785 colocalizes_with chromatin NAS 17468741
GO:0005634 nucleus IDA --
GO:0005654 nucleoplasm NAS 17468741
GO:0005737 cytoplasm IDA --
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with EIF3E: view

Pathways for EIF3E Gene

genes like me logo Genes that share pathways with EIF3E: view

Pathways by source for EIF3E Gene

Gene Ontology (GO) - Biological Process for EIF3E Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000184 nuclear-transcribed mRNA catabolic process, nonsense-mediated decay IMP 17468741
GO:0001731 formation of translation preinitiation complex IEA --
GO:0006412 translation TAS --
GO:0006413 translational initiation TAS --
GO:0006446 regulation of translational initiation NAS 17468741
genes like me logo Genes that share ontologies with EIF3E: view

Transcripts for EIF3E Gene

Unigene Clusters for EIF3E Gene

Eukaryotic translation initiation factor 3, subunit E:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for EIF3E Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6
SP1: -
SP2:
SP3:

Relevant External Links for EIF3E Gene

GeneLoc Exon Structure for
EIF3E
ECgene alternative splicing isoforms for
EIF3E

Expression for EIF3E Gene

mRNA expression in normal human tissues for EIF3E Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for EIF3E Gene

SOURCE GeneReport for Unigene cluster for EIF3E Gene Hs.405590

mRNA Expression by UniProt/SwissProt for EIF3E Gene

P60228-EIF3E_HUMAN
Tissue specificity: Ubiquitously expressed. Expressed at highest levels in appendix, lymph, pancreas, skeletal muscle, spleen and thymus.
genes like me logo Genes that share expressions with EIF3E: view

No data available for mRNA differential expression in normal tissues for EIF3E Gene

Orthologs for EIF3E Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for EIF3E Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia EIF3E 35
  • 98.13 (n)
  • 97.97 (a)
EIF3E 36
  • 98 (a)
OneToOne
cow
(Bos Taurus)
Mammalia EIF3E 35
  • 94.38 (n)
  • 99.78 (a)
EIF3E 36
  • 100 (a)
OneToOne
dog
(Canis familiaris)
Mammalia EIF3E 35
  • 94.61 (n)
  • 100 (a)
EIF3E 36
  • 100 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Eif3e 35
  • 90.79 (n)
  • 100 (a)
Eif3e 16
Eif3e 36
  • 100 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia EIF3E 36
  • 96 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia EIF3E 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Eif3e 35
  • 91.24 (n)
  • 100 (a)
chicken
(Gallus gallus)
Aves EIF3E 35
  • 84.27 (n)
  • 97.53 (a)
EIF3E 36
  • 98 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia EIF3E 36
  • 97 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia LOC398503 35
tropical clawed frog
(Silurana tropicalis)
Amphibia eif3e 35
  • 81.65 (n)
  • 96.63 (a)
MGC76151 35
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.10728 35
zebrafish
(Danio rerio)
Actinopterygii Dr.5119 35
eif3ea 35
  • 76.78 (n)
  • 93.48 (a)
eif3ea 36
  • 93 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta EIF3E_ANOGA 35
  • 58.41 (n)
  • 60.1 (a)
fruit fly
(Drosophila melanogaster)
Insecta Int6 35
  • 59.15 (n)
  • 60.93 (a)
Int6 36
  • 60 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea eif-3.E 35
  • 55.13 (n)
  • 51.31 (a)
eif-3.E 36
  • 50 (a)
OneToOne
Alicante grape
(Vitis vinifera)
eudicotyledons Vvi.5027 35
thale cress
(Arabidopsis thaliana)
eudicotyledons EIF3E 35
  • 57.38 (n)
  • 55.99 (a)
corn
(Zea mays)
Liliopsida Zm.15445 35
rice
(Oryza sativa)
Liliopsida Os.6714 35
Os07g0167000 35
  • 60.68 (n)
  • 59.52 (a)
wheat
(Triticum aestivum)
Liliopsida Ta.2821 35
bread mold
(Neurospora crassa)
Ascomycetes NCU05889 35
  • 50 (n)
  • 44.5 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes int6 35
  • 52.22 (n)
  • 45.71 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.2199 35
sea squirt
(Ciona savignyi)
Ascidiacea CSA.11027 36
  • 65 (a)
OneToOne
Species with no ortholog for EIF3E:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)

Evolution for EIF3E Gene

ENSEMBL:
Gene Tree for EIF3E (if available)
TreeFam:
Gene Tree for EIF3E (if available)

Paralogs for EIF3E Gene

genes like me logo Genes that share paralogs with EIF3E: view

No data available for Paralogs for EIF3E Gene

Variants for EIF3E Gene

Sequence variations from dbSNP and Humsavar for EIF3E Gene

SNP ID Clin Chr 08 pos Sequence Context AA Info Type MAF
rs371263 -- 108,211,777(+) GCACA(C/G)GAGCC intron-variant
rs377909 -- 108,201,597(-) TTTGT(C/G)TTACT downstream-variant-500B
rs414410 -- 108,204,807(+) gaCTG(A/T)ATTTC intron-variant
rs427145 -- 108,212,271(-) AAATG(C/T)AATAT intron-variant
rs475865 -- 108,223,629(-) TAATA(C/G)AATGC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for EIF3E Gene

Variant ID Type Subtype PubMed ID
esv24969 CNV Loss 19812545
esv2677243 CNV Deletion 23128226
esv2667842 CNV Deletion 23128226

Relevant External Links for EIF3E Gene

HapMap Linkage Disequilibrium report
EIF3E
Human Gene Mutation Database (HGMD)
EIF3E

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for EIF3E Gene

Disorders for EIF3E Gene

(4) Novoseek inferred disease relationships for EIF3E Gene

Disease -log(P) Hits PubMed IDs
mammary tumor 79.2 7
leukemia t-cell 48.2 1
nsclc 24.9 3
tumors 0 6

Relevant External Links for EIF3E

Genetic Association Database (GAD)
EIF3E
genes like me logo Genes that share disorders with EIF3E: view

No data available for UniProtKB/Swiss-Prot for EIF3E Gene

Publications for EIF3E Gene

  1. The translation initiation factor eIF3-p48 subunit is encoded by int- 6, a site of frequent integration by the mouse mammary tumor virus genome. (PMID: 9295280) Asano K. … Hershey J.W.B. (J. Biol. Chem. 1997) 2 3 4 23
  2. Interaction between the Ret finger protein and the Int-6 gene product and co-localisation into nuclear bodies. (PMID: 10504338) Morris-Desbois C. … Jalinot P. (J. Cell Sci. 1999) 3 4 23
  3. The human protein HSPC021 interacts with Int-6 and is associated with eukaryotic translation initiation factor 3. (PMID: 11590142) Morris-Desbois C. … Jalinot P. (J. Biol. Chem. 2001) 3 4 23
  4. Association of the mammalian proto-oncoprotein Int-6 with the three protein complexes eIF3, COP9 signalosome and 26S proteasome. (PMID: 12220626) Hoareau Alves K. … Jalinot P. (FEBS Lett. 2002) 3 4 23
  5. Human INT6/eIF3e is required for nonsense-mediated mRNA decay. (PMID: 17468741) Morris C. … Jalinot P. (EMBO Rep. 2007) 3 4 23

Products for EIF3E Gene

Sources for EIF3E Gene

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