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EIF3E Gene

protein-coding   GIFtS: 60
GCID: GC08M109215

Eukaryotic Translation Initiation Factor 3, Subunit E

(Previous names: eukaryotic translation initiation factor 3, subunit 6 48kDa)
(Previous symbols: INT6, EIF3S6)
  Search for EIF3E
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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This gene clusters with an RNA gene
Subcategory (RNA class): lncRNA

Quality score for the ORGUL clustered with this gene is 3

Aliases
Eukaryotic Translation Initiation Factor 3, Subunit E1 2     EIF3-P482
EIF3S61 2 3 5     eIF3-p462
INT61 2 3 5     Eukaryotic Translation Initiation Factor 3 Subunit E2
Eukaryotic Translation Initiation Factor 3, Subunit 6 48kDa1 2     Eukaryotic Translation Initiation Factor 3, Subunit 6 (48kD)2
Eukaryotic Translation Initiation Factor 3 Subunit 62 3     Mammary Tumor-Associated Protein INT62
Viral Integration Site Protein INT-6 Homolog2 3     Murine Mammary Tumor Integration Site 6 (Oncogene Homolog)2
EIF-3 P482 3     eIF3e3

External Ids:    HGNC: 32771   Entrez Gene: 36462   Ensembl: ENSG000001044087   OMIM: 6022105   UniProtKB: P602283   
ORGUL members:         

Export aliases for EIF3E gene to outside databases

Previous GC identifers: GC08M109284 GC08M104535


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for EIF3E Gene:
EIF3E (eukaryotic translation initiation factor 3, subunit E) is a protein-coding gene. GO annotations related to this gene include protein N-terminus binding and translation initiation factor activity.

UniProtKB/Swiss-Prot: EIF3E_HUMAN, P60228
Function: Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for
several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and
facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S preinitiation
complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG
recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal
complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation.
Required for nonsense-mediated mRNA decay (NMD); may act in conjunction with UPF2 to divert mRNAs from
translation to the NMD pathway. May interact with MCM7 and EPAS1 and regulate the proteasome-mediated degradation
of these proteins

Gene Wiki entry for EIF3E (EIF3S6) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000008.10  NC_018919.2  NT_008046.17  
Regulatory elements:
   Regulatory transcription factor binding sites in the EIF3E gene promoter:
         USF1   AML1a   AP-1   ATF-2   STAT5A   FOXO4   USF-1   c-Jun   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidEIF3E promoter sequence
   Search Chromatin IP Primers for EIF3E

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat EIF3E


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 8q22-q23   Ensembl cytogenetic band:  8q23.1   HGNC cytogenetic band: 8q22-q23

EIF3E Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
EIF3E gene location

GeneLoc information about chromosome 8         GeneLoc Exon Structure

GeneLoc location for GC08M109215:  view genomic region     (about GC identifiers)

Start:
109,213,445 bp from pter      End:
109,447,562 bp from pter
Size:
234,118 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: EIF3E_HUMAN, P60228 (See protein sequence)
Recommended Name: Eukaryotic translation initiation factor 3 subunit E  
Size: 445 amino acids; 52221 Da
Subunit: Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is composed of 13
subunits: EIF3A, EIF3B, EIF3C, EIF3D, EIF3E, EIF3F, EIF3G, EIF3H, EIF3I, EIF3J, EIF3K, EIF3L and EIF3M. The eIF-3
complex appears to include 3 stable modules: module A is composed of EIF3A, EIF3B, EIF3G and EIF3I; module B is
composed of EIF3F, EIF3H, and EIF3M; and module C is composed of EIF3C, EIF3D, EIF3E, EIF3K and EIF3L. EIF3C of
module C binds EIF3B of module A and EIF3H of module B, thereby linking the three modules. EIF3J is a labile
subunit that binds to the eIF-3 complex via EIF3B. The eIF-3 complex interacts with RPS6KB1 under conditions of
nutrient depletion. Mitogenic stimulation leads to binding and activation of a complex composed of MTOR and
RPTOR, leading to phosphorylation and release of RPS6KB1 and binding of EIF4B to eIF-3. Interacts with COPS3,
COPS6, COPS7 (COPS7A or COPS7B), EIF4G1, EPAS1, MCM7, NCBP1, PSMC6, TRIM27 and UPF2. Interacts with the HTLV-1
protein Tax-1. Interacts with IFIT1 and IFIT2
Mass spectrometry: Mass=52131.8; Method=Unknown; Range=1-445; Source=PubMed:17322308;
Mass spectrometry: Mass=52133.4; Mass_error=0.2; Method=MALDI; Range=1-445; Source=PubMed:18599441;
Secondary accessions: O43902 Q64058 Q64059 Q64252 Q6FG33 Q8WVK4

Explore the universe of human proteins at neXtProt for EIF3E: NX_P60228

Explore proteomics data for EIF3E at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys82, Lys93, Lys265, Lys387, Lys407, Lys409, Lys424, Lys425
  • Modification sites at PhosphoSitePlus

  • See EIF3E Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_001559.1  
    ENSEMBL proteins: 
     ENSP00000428170   ENSP00000220849   ENSP00000428796   ENSP00000430839   ENSP00000430709  
     ENSP00000430152   ENSP00000429327   ENSP00000430649   ENSP00000429968   ENSP00000430678  
    Reactome Protein details: P60228

    EIF3E Human Recombinant Protein Products:

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    4 InterPro protein domains:
     IPR016650 eIF3e
     IPR000717 PCI_dom
     IPR011991 WHTH_DNA-bd_dom
     IPR019010 eIF3e_N

    Graphical View of Domain Structure for InterPro Entry P60228

    ProtoNet protein and cluster: P60228

    UniProtKB/Swiss-Prot: EIF3E_HUMAN, P60228
    Similarity: Belongs to the eIF-3 subunit E family
    Similarity: Contains 1 PCI domain


    Find genes that share domains with EIF3E           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: EIF3E_HUMAN, P60228
    Function: Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for
    several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and
    facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S preinitiation
    complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG
    recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal
    complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation.
    Required for nonsense-mediated mRNA decay (NMD); may act in conjunction with UPF2 to divert mRNAs from
    translation to the NMD pathway. May interact with MCM7 and EPAS1 and regulate the proteasome-mediated degradation
    of these proteins

         Gene Ontology (GO): 4 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003743contributes to translation initiation factor activity IDA17581632
    GO:0005515protein binding IPI10504338
    GO:0044822poly(A) RNA binding IDA--
    GO:0047485protein N-terminus binding IPI10504338
         
    Find genes that share ontologies with EIF3E           About GenesLikeMe


    Phenotypes:
         7 GenomeRNAi human phenotypes for EIF3E:
     Decreased G3BP1 protein expres  Decreased cell number, increas  Decreased viability  Elongated cells 
     G2 arrest  Increased cell death in HCC-19  Synthetic lethal with Ras 

    Animal Models:
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    EIF3E_HUMAN, P60228: Cytoplasm. Nucleus, PML body
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    cytosol4
    mitochondrion1
    peroxisome1

    Gene Ontology (GO): Selected cellular component terms (see all 11):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000785colocalizes with chromatin NAS17468741
    GO:0005634nucleus IDA--
    GO:0005654nucleoplasm NAS17468741
    GO:0005730NOT nucleolus IDA--
    GO:0005737cytoplasm IDA--

    Find genes that share ontologies with EIF3E           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for EIF3E About   (see all 8)  
    See pathways by source

    SuperPathContained pathways About
    1Influenza Viral RNA Transcription and Replication
    L13a-mediated translational silencing of Ceruloplasmin expression0.94
    Cap-dependent Translation Initiation0.89
    Formation of a pool of free 40S subunits0.94
    Eukaryotic Translation Initiation0.89
    GTP hydrolysis and joining of the 60S ribosomal subunit0.93
    Translation0.82
    2Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S
    Translation initiation complex formation0.91
    Formation of the ternary complex, and subsequently, the 43S complex0.91
    Ribosomal scanning and start codon recognition0.91
    Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S0.90
    3Gene Expression
    Gene Expression0.40
    4Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein
    Metabolism of proteins0.30
    5Translation Factors
    Translation Factors


    Find genes that share SuperPaths with EIF3E           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    2 Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for EIF3E
        eIF2 Pathway
    mTOR Pathway

    2 BioSystems Pathways for EIF3E
        Translation Factors
    HIF-2-alpha transcription factor network


    Selected Reactome Pathways for EIF3E (see all 6)
        Formation of the ternary complex, and subsequently, the 43S complex
    L13a-mediated translational silencing of Ceruloplasmin expression
    GTP hydrolysis and joining of the 60S ribosomal subunit
    Ribosomal scanning and start codon recognition
    Formation of a pool of free 40S subunits


    2 Kegg Pathways  (Kegg details for EIF3E):
        RNA transport
    Hepatitis C

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for EIF3E
    Interactions:

        GeneGlobe Interaction Network for EIF3E

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for EIF3E (P602281, 2, 3 ENSP000002208494) via UniProtKB, MINT, STRING, and/or I2D (see all 754)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ENSG00000225748P486342, 3, ENSP000003874774MINT-62621 MINT-62719 MINT-62795 I2D: score=5 STRING: ENSP00000387477
    ENSG00000231825P486342, 3, ENSP000004153634MINT-62621 MINT-62719 MINT-62795 I2D: score=5 STRING: ENSP00000415363
    ENSG00000206427P486342, 3MINT-62621 MINT-62719 MINT-62795 I2D: score=5 
    ENSG00000225164P486342, 3MINT-62621 MINT-62719 MINT-62795 I2D: score=5 
    ENSG00000226618P486342, 3MINT-62621 MINT-62719 MINT-62795 I2D: score=5 
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000184nuclear-transcribed mRNA catabolic process, nonsense-mediated decay IMP17468741
    GO:0001731formation of translation preinitiation complex IEA--
    GO:0006412translation TAS--
    GO:0006413translational initiation TAS--
    GO:0006446regulation of translational initiation NAS17468741

    Find genes that share ontologies with EIF3E           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
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      Browse compounds at ApexBio 

    Browse Tocris compounds for EIF3E



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for EIF3E gene: 
    NM_001568.2  

    Unigene Cluster for EIF3E:

    Eukaryotic translation initiation factor 3, subunit E
    Hs.405590  [show with all ESTs]
    Unigene Representative Sequence: AK124178
    18 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000523674 ENST00000522352 ENST00000220849(uc003ymu.3) ENST00000519030
    ENST00000521614(uc003ymt.3) ENST00000519517 ENST00000519627 ENST00000519413
    ENST00000522445 ENST00000523646 ENST00000521440 ENST00000518442(uc010mcj.1)
    ENST00000518100 ENST00000522887 ENST00000521297 ENST00000518345 ENST00000518634
    ENST00000522088
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    Additional mRNA sequence: 

    AK124178.1 AK310902.1 AK313186.1 BC000734.2 BC005944.1 BC008419.1 BC016706.1 BC017887.1 
    BC021679.1 CR457029.1 CR542275.1 U54562.1 U62962.1 U85947.1 U94175.1 

    Selected DOTS entries (see all 41):

    DT.91873781  DT.91786530  DT.95109944  DT.40195311  DT.100040612  DT.91898358  DT.100887390  DT.100887394 
    DT.120632323  DT.120632268  DT.97860893  DT.99992062  DT.100887404  DT.121383379  DT.91970237  DT.100887382 
    DT.92331786  DT.100816985  DT.100887385  DT.120632257  DT.92470692  DT.100799277  DT.100887388  DT.120632266 

    Selected AceView cDNA sequences (see all 1388):

    AJ714889 BM478618 BU145151 BM454234 CA433315 BU172971 BM454003 AA315867 
    BU164182 N39500 BQ436528 BU155088 CD106073 CF130026 T31145 AI567374 
    F31255 CR617854 CR621914 BQ009094 CR625706 U62962 AI911187 CA396839 

    GeneLoc Exon Structure

    3 Alternative Splicing Database (ASD) splice patterns (SP) for EIF3E    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6
    SP1:              -                                 
    SP2:                                                
    SP3:                                                


    ECgene alternative splicing isoforms for EIF3E

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    EIF3E expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AATATTGAGA
    EIF3E Expression
    About this image


    EIF3E expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 21) fully expand
     
     Brain (Nervous System)    fully expand to see all 4 entries
             Cerebral Cortex
     
     Testis (Reproductive System)
             Leydig Cells Testis Interstitium
     
     Ovary (Reproductive System)
             Oviduct
     
     Pancreas (Endocrine System)
             Islets of Langerhans
     
     Trophoblast (Extraembryonic Tissues)
             Trophoblast Cells Trophoblast
    EIF3E Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    EIF3E Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.405590

    UniProtKB/Swiss-Prot: EIF3E_HUMAN, P60228
    Tissue specificity: Ubiquitously expressed. Expressed at highest levels in appendix, lymph, pancreas, skeletal
    muscle, spleen and thymus

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of eukaryotes.

    Orthologs for EIF3E gene from Selected species (see all 26)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Eif3e1 , 5 eukaryotic translation initiation factor 3, subunit more1, 5 90.79(n)1
    100(a)1
      15 (16.73 cM)5
    163411  NM_008388.21  NP_032414.11 
     432500405 
    chicken
    (Gallus gallus)
    Aves EIF3E1 eukaryotic translation initiation factor 3, subunit more 84.27(n)
    97.53(a)
      420272  NM_001006349.1  NP_001006349.1 
    lizard
    (Anolis carolinensis)
    Reptilia EIF3E6
    eukaryotic translation initiation factor 3, subuni...
    97(a)
    1 ↔ 1
    4(11247364-11338716)
    African clawed frog
    (Xenopus laevis)
    Amphibia LOC3985032 similar to eukaryotic translation initiation factor 81.35(n)    AF162775.1 
    zebrafish
    (Danio rerio)
    Actinopterygii Dr.51192 Danio rerio cDNA clone IMAGE5602796, partial cds 79.82(n)    BC057516.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Int61 Int6 homologue 59.15(n)
    60.93(a)
      39877  NM_058037.5  NP_477385.1 
    worm
    (Caenorhabditis elegans)
    Secernentea eif-3.E1 eif-3.E 55.13(n)
    51.31(a)
      172959  NM_060384.6  NP_492785.1 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons EIF3E1 EIF3E 57.38(n)
    55.99(a)
      824896  NM_115589.4  NP_567047.1 
    rice
    (Oryza sativa)
    Liliopsida Os.67142 Oryza sativa (japonica cultivar-group) cDNA cloneJ more 71.97(n)    AK065461.1 


    ENSEMBL Gene Tree for EIF3E (if available)
    TreeFam Gene Tree for EIF3E (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for EIF3E gene
    1 SIMAP similar gene for EIF3E using alignment to 11 protein entries:     EIF3E_HUMAN (see all proteins):
    EIF3S6

    Find genes that share paralogs with EIF3E           About GenesLikeMe


    Selected Pseudogenes.org Pseudogenes for EIF3E (see all 6)
    PGOHUM00000257039 PGOHUM00000257049 PGOHUM00000257050 PGOHUM00000241007 PGOHUM00000237888


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for EIF3E (see all 1065)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 8 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1131369341,2
    C--109213491(+) ATATA-/TATA  
      TCTATC
    TCTCA
    1 -- ds50011Minor allele frequency- TATATCTATC:0.00CSA 2
    rs558917511,2
    C--109213496(+) TATATA/CTATCT 1 -- ds50011Minor allele frequency- C:0.00NA 2
    rs16681801,2
    C,F--109213500(-) TGAGAT/GATAGA 1 -- ds50013Minor allele frequency- G:0.33NA WA 6
    rs1865329691,2
    --109213649(+) TAGAGC/TTGGTT 1 -- ds50010--------
    rs1882343041,2
    --109213653(+) GTTGGC/TTGGGA 1 -- ds50010--------
    rs1809400891,2
    C--109213697(+) GATCAC/TGATGA 1 -- ds50010--------
    rs733191571,2
    C,F--109213779(+) ACACAC/TATTGT 1 -- ds50015Minor allele frequency- T:0.12WA CSA 126
    rs3779091,2
    C,F,A,H--109213826(-) TTTGTG/CTTACT 1 -- ds500116Minor allele frequency- C:0.34EA NS NA WA CSA 647
    rs6035711,2
    C,F,A,H--109213893(-) AGGAAG/TTTGCA 1 -- ds500112Minor allele frequency- T:0.47NA WA CSA EA 378
    rs1861525231,2
    --109213979(+) AAATGA/CATCAA 1 -- ut310--------

    HapMap Linkage Disequilibrium report for EIF3E (109213445 - 109447562 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 3 variations for EIF3E:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2667842CNV Deletion23128226
    esv2677243CNV Deletion23128226
    esv24969CNV Loss19812545

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing EIF3E
    DNA2.0 Custom Variant and Variant Library Synthesis for EIF3E

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 602210    OMIM disorders: --


    Find genes that share disorders with EIF3E           About GenesLikeMe

    4 Novoseek inferred disease relationships for EIF3E gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    mammary tumor 79.2 13 9295280 (2), 8738604 (1), 11115556 (1), 11457827 (1) (see all 6)
    leukemia t-cell 48.2 1 9295280 (1)
    nsclc 24.9 4 15867213 (3)
    tumors 0 10 15867213 (2), 17385060 (2), 17895999 (1), 11536042 (1)

    Genetic Association Database (GAD): EIF3E

    Export disorders for EIF3E gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for EIF3E gene, integrated from 10 sources (see all 112):
    (articles sorted by number of sources associating them with EIF3E)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The translation initiation factor eIF3-p48 subunit is encoded by int- 6, a site of frequent integration by the mouse mammary tumor virus genome. (PubMed id 9295280)1, 2, 3, 9 Asano K.... Hershey J.W.B. (J. Biol. Chem. 1997)
    2. The chromosome location of the human homolog of the mouse mammary tumor-associated gene INT6 and its status in human breast carcinomas. (PubMed id 9403073)1, 2, 3 Miyazaki S.... Callahan R. (Genomics 1997)
    3. Interaction between the Ret finger protein and the Int-6 gene product and co-localisation into nuclear bodies. (PubMed id 10504338)1, 2, 9 Morris-Desbois C.... Jalinot P. (J. Cell Sci. 1999)
    4. The human protein HSPC021 interacts with Int-6 and is associated with eukaryotic translation initiation factor 3. (PubMed id 11590142)1, 2, 9 Morris-Desbois C.... Jalinot P. (J. Biol. Chem. 2001)
    5. Human INT6/eIF3e is required for nonsense-mediated mRNA decay. (PubMed id 17468741)1, 2, 9 Morris C.... Jalinot P. (EMBO Rep. 2007)
    6. Association of the mammalian proto-oncoprotein Int-6 with the three protein complexes eIF3, COP9 signalosome and 26S proteasome. (PubMed id 12220626)1, 2, 9 Hoareau Alves K.... Jalinot P. (FEBS Lett. 2002)
    7. Translation initiation factor eIF4G-1 binds to eIF3 through the eIF3e subunit. (PubMed id 16766523)1, 2, 9 LeFebvre A.K.... Rhoads R.E. (J. Biol. Chem. 2006)
    8. Wnt signaling and Dupuytren's disease. (PubMed id 21732829)1, 4 Dolmans G.H.... . (N. Engl. J. Med. 2011)
    9. Mass spectrometry reveals modularity and a complete subunit interaction map of the eukaryotic translation factor eIF3. (PubMed id 18599441)1, 2 Zhou M.... Robinson C.V. (Proc. Natl. Acad. Sci. U.S.A. 2008)
    10. Reconstitution reveals the functional core of mammalian eIF3. (PubMed id 17581632)1, 2 Masutani M.... Imataka H. (EMBO J. 2007)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 3646 HGNC: 3277 AceView: EIF3S6 Ensembl:ENSG00000104408 euGenes: HUgn3646
    ECgene: EIF3E Kegg: 3646 H-InvDB: EIF3E

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for EIF3E Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for EIF3E gene:
    Search GeneIP for patents involving EIF3E

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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