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Aliases for EIF3D Gene

Aliases for EIF3D Gene

  • Eukaryotic Translation Initiation Factor 3 Subunit D 2 3 5
  • Eukaryotic Translation Initiation Factor 3, Subunit 7 Zeta, 66/67kDa 2 3
  • EIF3 P66 3 4
  • EIF3S7 3 4
  • Eukaryotic Translation Initiation Factor 3, Subunit D 2
  • Eukaryotic Translation Initiation Factor 3 Subunit 7 4
  • Translation Initiation Factor EIF3 P66 Subunit 3
  • EIF-3-Zeta 4
  • EIF3-Zeta 3
  • EIF3-P66 3
  • EIF3d 4

External Ids for EIF3D Gene

Previous HGNC Symbols for EIF3D Gene

  • EIF3S7

Previous GeneCards Identifiers for EIF3D Gene

  • GC22M035221
  • GC22M036891
  • GC22M019874

Summaries for EIF3D Gene

Entrez Gene Summary for EIF3D Gene

  • Eukaryotic translation initiation factor-3 (eIF3), the largest of the eIFs, is a multiprotein complex composed of at least ten nonidentical subunits. The complex binds to the 40S ribosome and helps maintain the 40S and 60S ribosomal subunits in a dissociated state. It is also thought to play a role in the formation of the 40S initiation complex by interacting with the ternary complex of eIF2/GTP/methionyl-tRNA, and by promoting mRNA binding. The protein encoded by this gene is the major RNA binding subunit of the eIF3 complex. [provided by RefSeq, Jul 2008]

GeneCards Summary for EIF3D Gene

EIF3D (Eukaryotic Translation Initiation Factor 3 Subunit D) is a Protein Coding gene. Among its related pathways are Viral mRNA Translation and Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S. GO annotations related to this gene include poly(A) RNA binding and translation initiation factor activity.

UniProtKB/Swiss-Prot for EIF3D Gene

  • mRNA cap-binding component of the eukaryotic translation initiation factor 3 (eIF-3) complex, a complex required for several steps in the initiation of protein synthesis of a specialized repertoire of mRNAs (PubMed:27462815). The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation (PubMed:18599441, PubMed:25849773). The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, including cell cycling, differentiation and apoptosis, and uses different modes of RNA stem-loop binding to exert either translational activation or repression (PubMed:25849773). In the eIF-3 complex, EIF3D specifically recognizes and binds the 7-methylguanosine cap of a subset of mRNAs (PubMed:27462815).

  • (Microbial infection) In case of FCV infection, plays a role in the ribosomal termination-reinitiation event leading to the translation of VP2 (PubMed:18056426).

Gene Wiki entry for EIF3D Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for EIF3D Gene

Genomics for EIF3D Gene

Regulatory Elements for EIF3D Gene

Enhancers for EIF3D Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH22G036321 2.1 FANTOM5 Ensembl ENCODE dbSUPER 11 +195.9 195853 24.5 MLX CREB3L1 DMAP1 YY1 ZNF143 ZNF548 ZNF263 NFYC TBX21 MEF2D TXN2 ENSG00000252225 EIF3D RPS15AP38 IFT27 APOL3 GC22M036334 GC22P036326
GH22G036457 2 FANTOM5 Ensembl ENCODE dbSUPER 5.7 +64.1 64135 15.7 HDGF PKNOX1 ARNT AGO1 ARID4B SIN3A ZNF2 YY1 ZNF143 ZNF207 FOXRED2 ENSG00000252225 RPS15AP38 TXN2 ENSG00000228719 EIF3D MYH9 LOC105373018
GH22G036348 2.1 FANTOM5 Ensembl ENCODE dbSUPER 4.8 +160.6 160616 40.9 MLX CREB3L1 DMAP1 YBX1 FEZF1 YY1 SLC30A9 ZNF143 ZNF263 SP3 TXN2 ENSG00000252225 FOXRED2 MYH9 LOC105377199 APOL3 EIF3D ENSG00000228719 APOL2 NCF4
GH22G036394 1.5 Ensembl ENCODE dbSUPER 5.3 +132.3 132269 5.7 ATF1 FEZF1 DMAP1 GATA2 FOS SP5 JUNB PPARG KAT8 ATF4 ENSG00000252225 FOXRED2 ENSG00000228719 TXN2 MYH9 EIF3D GC22M036384 GC22P036390
GH22G036527 1.1 ENCODE 6.8 +0.5 524 3.6 HDGF PKNOX1 FOXA2 CREB3L1 ARNT ZFP64 WRNIP1 ARID4B SIN3A DMAP1 EIF3D FOXRED2
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around EIF3D on UCSC Golden Path with GeneCards custom track

Promoters for EIF3D Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000145872 436 2001 HDGF PKNOX1 FOXA2 CREB3L1 ARNT ZFP64 WRNIP1 ARID4B SIN3A DMAP1

Genomic Location for EIF3D Gene

Chromosome:
22
Start:
36,510,850 bp from pter
End:
36,529,436 bp from pter
Size:
18,587 bases
Orientation:
Minus strand

Genomic View for EIF3D Gene

Genes around EIF3D on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
EIF3D Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for EIF3D Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for EIF3D Gene

Proteins for EIF3D Gene

  • Protein details for EIF3D Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O15371-EIF3D_HUMAN
    Recommended name:
    Eukaryotic translation initiation factor 3 subunit D
    Protein Accession:
    O15371
    Secondary Accessions:
    • A8MWD3
    • B2R7D4
    • B4DTF8
    • B4DVY1
    • Q3MJD9
    • Q5M9Q6

    Protein attributes for EIF3D Gene

    Size:
    548 amino acids
    Molecular mass:
    63973 Da
    Quaternary structure:
    • Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is composed of 13 subunits: EIF3A, EIF3B, EIF3C, EIF3D, EIF3E, EIF3F, EIF3G, EIF3H, EIF3I, EIF3J, EIF3K, EIF3L and EIF3M. The eIF-3 complex appears to include 3 stable modules: module A is composed of EIF3A, EIF3B, EIF3G and EIF3I; module B is composed of EIF3F, EIF3H, and EIF3M; and module C is composed of EIF3C, EIF3D, EIF3E, EIF3K and EIF3L. EIF3C of module C binds EIF3B of module A and EIF3H of module B, thereby linking the three modules. EIF3J is a labile subunit that binds to the eIF-3 complex via EIF3B. The eIF-3 complex interacts with RPS6KB1 under conditions of nutrient depletion. Mitogenic stimulation leads to binding and activation of a complex composed of MTOR and RPTOR, leading to phosphorylation and release of RPS6KB1 and binding of EIF4B to eIF-3.
    • (Microbial infection) Interacts with Norwalk virus VPg protein (PubMed:12773399).

    Alternative splice isoforms for EIF3D Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for EIF3D Gene

Post-translational modifications for EIF3D Gene

  • Ubiquitination at Lys35, Lys41, isoforms=2, 353, isoforms=2142, and isoforms=2, 3204
  • Modification sites at PhosphoSitePlus

Other Protein References for EIF3D Gene

No data available for DME Specific Peptides for EIF3D Gene

Domains & Families for EIF3D Gene

Gene Families for EIF3D Gene

Protein Domains for EIF3D Gene

Graphical View of Domain Structure for InterPro Entry

O15371

UniProtKB/Swiss-Prot:

EIF3D_HUMAN :
  • The RNA gate region regulates mRNA cap recognition to prevent promiscuous mRNA-binding before assembly of EIF3D into the full eukaryotic translation initiation factor 3 (eIF-3) complex.
  • Belongs to the eIF-3 subunit D family.
Domain:
  • The RNA gate region regulates mRNA cap recognition to prevent promiscuous mRNA-binding before assembly of EIF3D into the full eukaryotic translation initiation factor 3 (eIF-3) complex.
Family:
  • Belongs to the eIF-3 subunit D family.
genes like me logo Genes that share domains with EIF3D: view

Function for EIF3D Gene

Molecular function for EIF3D Gene

UniProtKB/Swiss-Prot Function:
mRNA cap-binding component of the eukaryotic translation initiation factor 3 (eIF-3) complex, a complex required for several steps in the initiation of protein synthesis of a specialized repertoire of mRNAs (PubMed:27462815). The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation (PubMed:18599441, PubMed:25849773). The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, including cell cycling, differentiation and apoptosis, and uses different modes of RNA stem-loop binding to exert either translational activation or repression (PubMed:25849773). In the eIF-3 complex, EIF3D specifically recognizes and binds the 7-methylguanosine cap of a subset of mRNAs (PubMed:27462815).
UniProtKB/Swiss-Prot Function:
(Microbial infection) In case of FCV infection, plays a role in the ribosomal termination-reinitiation event leading to the translation of VP2 (PubMed:18056426).

Gene Ontology (GO) - Molecular Function for EIF3D Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003723 RNA binding IEA,IDA 22658674
GO:0003743 contributes_to translation initiation factor activity IDA,IEA 17581632
GO:0005515 protein binding IPI 11369516
GO:0098808 mRNA cap binding IDA 27462815
genes like me logo Genes that share ontologies with EIF3D: view
genes like me logo Genes that share phenotypes with EIF3D: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for EIF3D Gene

Localization for EIF3D Gene

Subcellular locations from UniProtKB/Swiss-Prot for EIF3D Gene

Cytoplasm.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for EIF3D gene
Compartment Confidence
cytosol 5
nucleus 1

Gene Ontology (GO) - Cellular Components for EIF3D Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
GO:0005829 cytosol TAS --
GO:0005852 eukaryotic translation initiation factor 3 complex IEA,IDA 17322308
GO:0016020 membrane IDA 19946888
GO:0071541 eukaryotic translation initiation factor 3 complex, eIF3m IEA --
genes like me logo Genes that share ontologies with EIF3D: view

Pathways & Interactions for EIF3D Gene

genes like me logo Genes that share pathways with EIF3D: view

Gene Ontology (GO) - Biological Process for EIF3D Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001732 formation of cytoplasmic translation initiation complex IEA --
GO:0002191 cap-dependent translational initiation IDA 27462815
GO:0006412 translation IEA --
GO:0006413 translational initiation TAS,IEA --
GO:0045727 positive regulation of translation IPI 24092755
genes like me logo Genes that share ontologies with EIF3D: view

No data available for SIGNOR curated interactions for EIF3D Gene

Drugs & Compounds for EIF3D Gene

(1) Drugs for EIF3D Gene - From: ApexBio

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
eukaryotic translation initiation factor 3 Pharma Eukaryotic translation initiator 0

(1) ApexBio Compounds for EIF3D Gene

Compound Action Cas Number
eukaryotic translation initiation factor 3 Eukaryotic translation initiator
genes like me logo Genes that share compounds with EIF3D: view

Drug Products

Transcripts for EIF3D Gene

Unigene Clusters for EIF3D Gene

Eukaryotic translation initiation factor 3, subunit D:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for EIF3D Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3 ^ 4 ^ 5a · 5b ^ 6a · 6b ^ 7 ^ 8a · 8b ^ 9a · 9b ^ 10 ^ 11a · 11b ^ 12a · 12b · 12c ^ 13a · 13b ^ 14 ^ 15a ·
SP1: - - - - - -
SP2: - - -
SP3: -
SP4:
SP5: -
SP6: - -
SP7:

ExUns: 15b · 15c
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:

Relevant External Links for EIF3D Gene

GeneLoc Exon Structure for
EIF3D
ECgene alternative splicing isoforms for
EIF3D

Expression for EIF3D Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for EIF3D Gene

Protein differential expression in normal tissues from HIPED for EIF3D Gene

This gene is overexpressed in Peripheral blood mononuclear cells (13.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for EIF3D Gene



Protein tissue co-expression partners for EIF3D Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of EIF3D Gene:

EIF3D

SOURCE GeneReport for Unigene cluster for EIF3D Gene:

Hs.55682

Evidence on tissue expression from TISSUES for EIF3D Gene

  • Nervous system(5)
  • Lung(4.8)
  • Skin(4.8)
  • Blood(4.6)
  • Liver(4.6)
  • Stomach(4.6)
  • Muscle(4.5)
  • Intestine(4.1)
  • Kidney(3.4)
  • Eye(2.9)
  • Heart(2.7)
  • Spleen(2.4)
  • Lymph node(2.1)
  • Pancreas(2.1)
  • Thyroid gland(2)
genes like me logo Genes that share expression patterns with EIF3D: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for EIF3D Gene

Orthologs for EIF3D Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for EIF3D Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia EIF3D 34 35
  • 99.7 (n)
oppossum
(Monodelphis domestica)
Mammalia EIF3D 35
  • 98 (a)
OneToOne
dog
(Canis familiaris)
Mammalia EIF3D 34 35
  • 92.64 (n)
cow
(Bos Taurus)
Mammalia EIF3D 34 35
  • 91.24 (n)
mouse
(Mus musculus)
Mammalia Eif3d 34 16 35
  • 91.06 (n)
rat
(Rattus norvegicus)
Mammalia Eif3d 34
  • 90.39 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia EIF3D 35
  • 86 (a)
OneToOne
chicken
(Gallus gallus)
Aves EIF3D 34 35
  • 84.5 (n)
lizard
(Anolis carolinensis)
Reptilia EIF3D 35
  • 95 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia eif3d 34
  • 79.08 (n)
MGC75703 34
African clawed frog
(Xenopus laevis)
Amphibia eif3s7-prov 34
zebrafish
(Danio rerio)
Actinopterygii eif3d 34 35
  • 80.78 (n)
eif3s7 34
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.56 34
African malaria mosquito
(Anopheles gambiae)
Insecta EIF3D_ANOGA 34
  • 63.65 (n)
fruit fly
(Drosophila melanogaster)
Insecta eIF-3p66 34 35
  • 63.21 (n)
CG4810 35
  • 53 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea eif-3.D 34 35
  • 52.92 (n)
thale cress
(Arabidopsis thaliana)
eudicotyledons AT4G20980 34
  • 52.19 (n)
rice
(Oryza sativa)
Liliopsida Os05g0566500 34
  • 54.69 (n)
Os.11175 34
barley
(Hordeum vulgare)
Liliopsida Hv.5674 34
wheat
(Triticum aestivum)
Liliopsida Ta.2841 34
corn
(Zea mays)
Liliopsida Zm.5251 34
sea squirt
(Ciona savignyi)
Ascidiacea CSA.5441 35
  • 62 (a)
OneToOne
bread mold
(Neurospora crassa)
Ascomycetes NCU07380 34
  • 51.7 (n)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes moe1 34
  • 49.55 (n)
Species where no ortholog for EIF3D was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)

Evolution for EIF3D Gene

ENSEMBL:
Gene Tree for EIF3D (if available)
TreeFam:
Gene Tree for EIF3D (if available)

Paralogs for EIF3D Gene

No data available for Paralogs for EIF3D Gene

Variants for EIF3D Gene

Sequence variations from dbSNP and Humsavar for EIF3D Gene

SNP ID Clin Chr 22 pos Sequence Context AA Info Type
rs1000097604 -- 36,529,490(+) CGCGC(C/T)TCAGC upstream-variant-2KB
rs1000113034 -- 36,524,836(+) CTGTA(A/G)CATTG intron-variant
rs1000282450 -- 36,529,018(+) AGGCT(-/G)GACCT intron-variant
rs1000404012 -- 36,529,298(+) GTTAC(C/T)GCGTT nc-transcript-variant, upstream-variant-2KB
rs1000416121 -- 36,524,120(+) CTACG(C/G)CATCA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for EIF3D Gene

Variant ID Type Subtype PubMed ID
esv23004 CNV loss 19812545
esv2758836 CNV loss 17122850
esv2760722 CNV gain 21179565
nsv1060004 CNV gain 25217958
nsv3615 CNV insertion 18451855
nsv520497 CNV gain 19592680

Variation tolerance for EIF3D Gene

Residual Variation Intolerance Score: 7.48% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.36; 8.02% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for EIF3D Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
EIF3D

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for EIF3D Gene

Disorders for EIF3D Gene

UniProtKB/Swiss-Prot

EIF3D_HUMAN
  • Note=Defects in EIF3D are associated with some cancers, such as prostate, breast and colon cancers. Disease susceptibility may be associated with variations affecting the gene represented in this entry. Down-regulation inhibits proliferation of cancers (PubMed:25370813, PubMed:25322666, PubMed:25682860, PubMed:26617750, PubMed:26008152, PubMed:26036682, PubMed:27035563). {ECO:0000269 PubMed:25322666, ECO:0000269 PubMed:25370813, ECO:0000269 PubMed:25682860, ECO:0000269 PubMed:26008152, ECO:0000269 PubMed:26036682, ECO:0000269 PubMed:26617750, ECO:0000269 PubMed:27035563}.

Relevant External Links for EIF3D

Genetic Association Database (GAD)
EIF3D
Human Genome Epidemiology (HuGE) Navigator
EIF3D
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
EIF3D

No disorders were found for EIF3D Gene.

No data available for MalaCards and Genatlas for EIF3D Gene

Publications for EIF3D Gene

  1. Structure of cDNAs encoding human eukaryotic initiation factor 3 subunits. Possible roles in RNA binding and macromolecular assembly. (PMID: 9341143) Asano K. … Hershey J.W.B. (J. Biol. Chem. 1997) 2 3 4 64
  2. EIF3D silencing suppresses renal cell carcinoma tumorigenesis via inducing G2/M arrest through downregulation of Cyclin B1/CDK1 signaling. (PMID: 27035563) Pan X.W. … Cui X.G. (Int. J. Oncol. 2016) 3 4 64
  3. eIF3d is an mRNA cap-binding protein that is required for specialized translation initiation. (PMID: 27462815) Lee A.S. … Cate J.H. (Nature 2016) 3 4 64
  4. eIF3 targets cell-proliferation messenger RNAs for translational activation or repression. (PMID: 25849773) Lee A.S. … Cate J.H. (Nature 2015) 3 4 64
  5. Knockdown of EIF3D suppresses proliferation of human melanoma cells through G2/M phase arrest. (PMID: 25322666) Li H. … Yang S. (Biotechnol. Appl. Biochem. 2015) 3 4 64

Products for EIF3D Gene

Sources for EIF3D Gene

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