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Aliases for EIF3CL Gene

Aliases for EIF3CL Gene

  • Eukaryotic Translation Initiation Factor 3 Subunit C Like 2 3 5
  • Eukaryotic Translation Initiation Factor 3, Subunit C-Like 2

External Ids for EIF3CL Gene

Previous GeneCards Identifiers for EIF3CL Gene

  • GC16M028299

Summaries for EIF3CL Gene

Entrez Gene Summary for EIF3CL Gene

  • The protein encoded by this gene is a core subunit of the eukaryotic translation initiation factor 3 (eIF3) complex. The encoded protein is nearly identical to another protein, eIF3c, from a related gene. The eIF3 complex binds the 40S ribosome and mRNAs to enable translation initiation. Several transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Dec 2015]

GeneCards Summary for EIF3CL Gene

EIF3CL (Eukaryotic Translation Initiation Factor 3 Subunit C Like) is a Protein Coding gene. Among its related pathways are Viral mRNA Translation and Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S. GO annotations related to this gene include translation initiation factor activity and translation initiation factor binding. An important paralog of this gene is EIF3C.

UniProtKB/Swiss-Prot for EIF3CL Gene

  • Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, including cell cycling, differentiation and apoptosis, and uses different modes of RNA stem-loop binding to exert either translational activation or repression.

Additional gene information for EIF3CL Gene

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for EIF3CL Gene

Genomics for EIF3CL Gene

Regulatory Elements for EIF3CL Gene

Enhancers for EIF3CL Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH16H029028 1.5 Ensembl ENCODE dbSUPER 23.7 -625.4 -625443 1 ATF1 ZNF121 GTF3C2 GLIS2 FOS ATF7 RUNX3 NCOA1 JUNB ZNF592 SMG1P2 EIF3CL EIF3C ENSG00000260853 SPNS1 NFATC2IP ENSG00000260367 ATXN2L INO80E TAOK2
GH16H028861 1.2 ENCODE 10 -460.7 -460742 5 HDGF ARNT ZFP64 ARID4B SIN3A DMAP1 ZBTB7B YY1 ZNF766 CBX5 TUFM ATXN2L ENSG00000260853 NPIPB12 NFATC2IP SPNS1 ENSG00000260367 SMG1P2 SULT1A2 NPIPB10P
GH16H027429 1.2 ENCODE dbSUPER 10 +972.2 972244 3 PKNOX1 ARNT TCF12 GTF3C2 GATA2 ZNF143 FOS ATF7 RUNX3 NCOA1 IL21R KDM8 EIF3CL IL21R-AS1
GH16H028950 1.1 ENCODE 10.3 -547.4 -547441 2 HDGF PKNOX1 ARID4B SIN3A ZNF2 ZBTB7B YY1 ZNF143 FOS DEK SGF29 NFATC2IP EIF3C SULT1A2 ATXN2L NPIPB8 NPIPB10P SMG1P2 EIF3CL ENSG00000260853
GH16H029271 1.8 FANTOM5 Ensembl ENCODE dbSUPER 5.1 -868.4 -868370 2 YBX3 HDGF TBP PKNOX1 FOXA2 ARNT NFRKB SIN3A YBX1 NFXL1 SPNS1 INO80E ATXN2L NFATC2IP ENSG00000260953 ENSG00000260853 SMG1P2 ENSG00000198106 ENSG00000260367 NPIPB12
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around EIF3CL on UCSC Golden Path with GeneCards custom track

Promoters for EIF3CL Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000084889 279 1201

Genomic Location for EIF3CL Gene

Chromosome:
16
Start:
28,379,579 bp from pter
End:
28,403,879 bp from pter
Size:
24,301 bases
Orientation:
Minus strand

Genomic View for EIF3CL Gene

Genes around EIF3CL on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
EIF3CL Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for EIF3CL Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for EIF3CL Gene

Proteins for EIF3CL Gene

  • Protein details for EIF3CL Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    B5ME19-EIFCL_HUMAN
    Recommended name:
    Eukaryotic translation initiation factor 3 subunit C-like protein
    Protein Accession:
    B5ME19

    Protein attributes for EIF3CL Gene

    Size:
    914 amino acids
    Molecular mass:
    105473 Da
    Quaternary structure:
    • Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is composed of 13 subunits: EIF3A, EIF3B, EIF3C, EIF3D, EIF3E, EIF3F, EIF3G, EIF3H, EIF3I, EIF3J, EIF3K, EIF3L and EIF3M. The eIF-3 complex appears to include 3 stable modules: module A is composed of EIF3A, EIF3B, EIF3G and EIF3I; module B is composed of EIF3F, EIF3H, and EIF3M; and module C is composed of EIF3C, EIF3D, EIF3E, EIF3K and EIF3L. EIF3C of module C binds EIF3B of module A and EIF3H of module B, thereby linking the three modules. EIF3J is a labile subunit that binds to the eIF-3 complex via EIF3B. The eIF-3 complex interacts with RPS6KB1 under conditions of nutrient depletion. Mitogenic stimulation leads to binding and activation of a complex composed of MTOR and RPTOR, leading to phosphorylation and release of RPS6KB1 and binding of EIF4B to eIF-3 (By similarity).

neXtProt entry for EIF3CL Gene

Post-translational modifications for EIF3CL Gene

  • Phosphorylated. Phosphorylation is enhanced upon serum stimulation (By similarity).
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for EIF3CL Gene

No data available for DME Specific Peptides for EIF3CL Gene

Domains & Families for EIF3CL Gene

Gene Families for EIF3CL Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for EIF3CL Gene

Suggested Antigen Peptide Sequences for EIF3CL Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

B5ME19

UniProtKB/Swiss-Prot:

EIFCL_HUMAN :
  • Belongs to the eIF-3 subunit C family.
Family:
  • Belongs to the eIF-3 subunit C family.
genes like me logo Genes that share domains with EIF3CL: view

Function for EIF3CL Gene

Molecular function for EIF3CL Gene

UniProtKB/Swiss-Prot Function:
Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, including cell cycling, differentiation and apoptosis, and uses different modes of RNA stem-loop binding to exert either translational activation or repression.

Phenotypes From GWAS Catalog for EIF3CL Gene

Gene Ontology (GO) - Molecular Function for EIF3CL Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003743 contributes_to translation initiation factor activity IBA --
GO:0031369 translation initiation factor binding IBA --
genes like me logo Genes that share ontologies with EIF3CL: view

Phenotypes for EIF3CL Gene

GenomeRNAi human phenotypes for EIF3CL:
genes like me logo Genes that share phenotypes with EIF3CL: view

Animal Model Products

CRISPR Products

miRNA for EIF3CL Gene

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for EIF3CL
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for EIF3CL Gene

Localization for EIF3CL Gene

Subcellular locations from UniProtKB/Swiss-Prot for EIF3CL Gene

Cytoplasm.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for EIF3CL gene
Compartment Confidence
nucleus 2
cytosol 2

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for EIF3CL Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
GO:0005852 eukaryotic translation initiation factor 3 complex IBA --
genes like me logo Genes that share ontologies with EIF3CL: view

Pathways & Interactions for EIF3CL Gene

genes like me logo Genes that share pathways with EIF3CL: view

Gene Ontology (GO) - Biological Process for EIF3CL Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006412 translation IEA --
GO:0006413 translational initiation IBA --
genes like me logo Genes that share ontologies with EIF3CL: view

No data available for SIGNOR curated interactions for EIF3CL Gene

Drugs & Compounds for EIF3CL Gene

No Compound Related Data Available

Transcripts for EIF3CL Gene

mRNA/cDNA for EIF3CL Gene

(5) REFSEQ mRNAs :
(0) Additional mRNA sequences :
-
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for EIF3CL Gene

Eukaryotic translation initiation factor 3, subunit C-like:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for EIF3CL
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for EIF3CL Gene

No ASD Table

Relevant External Links for EIF3CL Gene

GeneLoc Exon Structure for
EIF3CL
ECgene alternative splicing isoforms for
EIF3CL

Expression for EIF3CL Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for EIF3CL Gene

Protein differential expression in normal tissues from HIPED for EIF3CL Gene

This gene is overexpressed in Lymph node (7.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for EIF3CL Gene



Protein tissue co-expression partners for EIF3CL Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of EIF3CL Gene:

EIF3CL

SOURCE GeneReport for Unigene cluster for EIF3CL Gene:

Hs.535464

Evidence on tissue expression from TISSUES for EIF3CL Gene

  • Nervous system(4.6)
  • Lung(4.3)
  • Skin(4.3)
  • Intestine(4.2)
  • Eye(3.9)
  • Liver(3.6)
  • Muscle(2.9)
  • Kidney(2.8)
  • Pancreas(2.8)
  • Stomach(2.5)
  • Heart(2.2)
genes like me logo Genes that share expression patterns with EIF3CL: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for EIF3CL Gene

Orthologs for EIF3CL Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for EIF3CL Gene

Organism Taxonomy Gene Similarity Type Details
dog
(Canis familiaris)
Mammalia -- 34
  • 99 (a)
OneToMany
chimpanzee
(Pan troglodytes)
Mammalia -- 34
  • 99 (a)
OneToMany
cow
(Bos Taurus)
Mammalia EIF3C 34
  • 98 (a)
OneToMany
mouse
(Mus musculus)
Mammalia Eif3c 34
  • 97 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia -- 34
  • 96 (a)
ManyToMany
-- 34
  • 93 (a)
ManyToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 91 (a)
OneToMany
chicken
(Gallus gallus)
Aves -- 34
  • 87 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 34
  • 87 (a)
OneToMany
zebrafish
(Danio rerio)
Actinopterygii eif3c 34
  • 74 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta eIF3-S8 34
  • 52 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea eif-3.C 34
  • 42 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes NIP1 34 36
  • 25 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 55 (a)
OneToMany
Species where no ortholog for EIF3CL was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for EIF3CL Gene

ENSEMBL:
Gene Tree for EIF3CL (if available)
TreeFam:
Gene Tree for EIF3CL (if available)

Paralogs for EIF3CL Gene

Paralogs for EIF3CL Gene

(1) SIMAP similar genes for EIF3CL Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with EIF3CL: view

Variants for EIF3CL Gene

Sequence variations from dbSNP and Humsavar for EIF3CL Gene

SNP ID Clin Chr 16 pos Sequence Context AA Info Type
rs1000148590 -- 28,382,490(+) TTCCC(-/CA)CAAAG intron-variant
rs1002867940 -- 28,396,872(+) AGGCC(C/G)AGGCA intron-variant
rs1003494382 -- 28,402,451(+) CAACC(G/T)GCTAA intron-variant
rs1004969234 -- 28,379,082(+) ATGAA(C/G)AGGTA downstream-variant-500B
rs1006341630 -- 28,402,356(+) GCAAT(C/G)TCGGC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for EIF3CL Gene

Variant ID Type Subtype PubMed ID
dgv13n14 CNV gain 18776910
dgv2830n100 CNV gain 25217958
dgv4964n54 CNV loss 21841781
dgv4965n54 CNV loss 21841781
dgv4966n54 CNV loss 21841781
dgv4967n54 CNV loss 21841781
dgv813e212 CNV loss 25503493
esv23667 CNV gain+loss 19812545
esv25666 CNV gain+loss 19812545
esv2758640 CNV gain+loss 17122850
esv2920457 CNV deletion 24192839
esv3892824 CNV loss 25118596
esv999954 CNV loss 20482838
nsv1059555 CNV gain 25217958
nsv1064483 CNV loss 25217958
nsv1066415 CNV gain 25217958
nsv1115498 CNV duplication 24896259
nsv1124734 CNV duplication 24896259
nsv1776 CNV deletion 18451855
nsv510683 CNV deletion 20534489
nsv511572 CNV loss 21212237
nsv571724 CNV loss 21841781
nsv571780 CNV loss 21841781
nsv571783 CNV loss 21841781
nsv821114 CNV deletion 20802225
nsv833180 CNV loss 17160897
nsv9414 CNV gain+loss 18304495
nsv9419 CNV gain+loss 18304495
nsv952962 CNV deletion 24416366
nsv977947 CNV duplication 23825009
nsv984297 CNV duplication 23825009
nsv984299 CNV duplication 23825009

Variation tolerance for EIF3CL Gene

Gene Damage Index Score: 4.77; 66.66% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for EIF3CL Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
EIF3CL

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for EIF3CL Gene

Disorders for EIF3CL Gene

Relevant External Links for EIF3CL

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
EIF3CL

No disorders were found for EIF3CL Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for EIF3CL Gene

Publications for EIF3CL Gene

  1. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 60
  2. An organelle-specific protein landscape identifies novel diseases and molecular mechanisms. (PMID: 27173435) Boldt K … UK10K Rare Diseases Group (Nature communications 2016) 3 60
  3. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin EL … Gygi SP (Cell 2015) 3 60
  4. Panorama of ancient metazoan macromolecular complexes. (PMID: 26344197) Wan C … Emili A (Nature 2015) 3 60
  5. Quantitative Proteomics Reveals Dynamic Interactions of the Minichromosome Maintenance Complex (MCM) in the Cellular Response to Etoposide Induced DNA Damage. (PMID: 25963833) Drissi R … Boisvert FM (Molecular & cellular proteomics : MCP 2015) 3 60

Products for EIF3CL Gene

Sources for EIF3CL Gene

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