EIF3CL Gene
protein-coding GIFtS: 43
GCID: GC16M028390
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eukaryotic translation initiation factor 3, subunit C-like
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Aliases for EIF3CL gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb) About This Section
|
| Aliases |
|---|
| Eukaryotic Translation Initiation Factor 3, Subunit C-Like1 2 | | Eukaryotic Translation Initiation Factor 3 Subunit C2 | | Eukaryotic Translation Initiation Factor 3 Subunit 82 3 | | Eukaryotic Translation Initiation Factor 3, Subunit 8, 110kDa-Like2 | | EIF3c1 | | EIF3S83 | | EIF3 P1102 3 | | |
Export aliases for EIF3CL gene to outside databasesPrevious GC identifer: GC16M028299 |
Summaries for EIF3CL gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
| UniProtKB/Swiss-Prot: EIF3C_HUMAN, Q99613Function: Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for severalsteps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and facilitates therecruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S preinitiation complex (43S PIC). TheeIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequentlyprevents premature joining of the 40S and 60S ribosomal subunits prior to initiation
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Genomic Views for EIF3CL gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics) About This Section
| RefSeq DNA sequence:- NC_018927.1 NC_000016.9 NT_010393.16
Regulatory elements: SABiosciences Regulatory transcription factor binding sites in the EIF3CL gene promoter: NF-1/L NF-1 GATA-3 HSF1 (long) GATA-1 GATA-2 PPAR-alpha HSF2 c-Myb HSF1short Other transcription factors
Search SABiosciences Chromatin IP Primers for EIF3CL
Epigenetics:
|  | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat EIF3CL |
Genomic Location: Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 16p11.2 Ensembl cytogenetic band: 16p11.2 HGNC cytogenetic band: 16p11.2EIF3CL Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different)

GeneLoc information about chromosome 16 GeneLoc Exon Structure GeneLoc location for GC16M028390: view genomic region
(about GC identifiers)
Start:
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28,390,900 bp from pter |
End:
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28,415,200 bp from pter |
Size:
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24,301 bases |
Orientation:
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minus strand |
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Proteins for EIF3CL gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
| UniProtKB/Swiss-Prot: EIF3C_HUMAN, Q99613 (See
protein sequence)Recommended Name: Eukaryotic translation initiation factor 3 subunit C Size: 913 amino acids; 105344 Da
Subunit: Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is composed of 13 subunits:EIF3A, EIF3B, EIF3C, EIF3D, EIF3E, EIF3F, EIF3G, EIF3H, EIF3I, EIF3J, EIF3K, EIF3L and EIF3M. The eIF-3 complexappears to include 3 stable modules: module A is composed of EIF3A, EIF3B, EIF3G and EIF3I; module B is composed ofEIF3F, EIF3H, and EIF3M; and module C is composed of EIF3C, EIF3D, EIF3E, EIF3K and EIF3L. EIF3C of module C bindsEIF3B of module A and EIF3H of module B, thereby linking the three modules. EIF3J is a labile subunit that binds tothe eIF-3 complex via EIF3B. The eIF-3 complex interacts with RPS6KB1 under conditions of nutrient depletion.Mitogenic stimulation leads to binding and activation of a complex composed of MTOR and RPTOR, leading tophosphorylation and release of RPS6KB1 and binding of EIF4B to eIF-3. Identified in a HCV IRES-mediated translationcomplex, at least composed of EIF3C, IGF2BP1, RPS3 and HCV RNA-replicon. Interacts with IFIT1 and IFIT2
Subcellular location: Cytoplasm (By similarity)
Mass spectrometry: Mass=106143.8; Method=Unknown; Range=1-913; Source=PubMed:17322308;
Mass spectrometry: Mass=106855; Mass_error=40; Method=MALDI; Range=1-913; Source=PubMed:18599441;
Secondary accessions: A8K7Z0 B2RXG3 O00215 Q9BW98Explore the universe of human proteins at neXtProt for EIF3CL: NX_Q99613
Post-translational modifications:
Phosphorylated. Phosphorylation is enhanced upon serum stimulation1
View modification sites using PhosphoSitePlus2 (eIF3CL)View neXtProt modification sites for NX_Q99613 EIF3CL Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_001093131.1 ENSEMBL proteins: ENSP00000370258 ENSP00000381917 ENSP00000381916 Reactome Protein details: Q99613 Human Recombinant Protein Products:
Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005852 | eukaryotic translation initiation factor 3 complex |
-- | -- |
EIF3CL for ontologies About GeneDecksing
EIF3CL Antibody Products: Assay Products for EIF3CL: |
Protein
Domains / Families for EIF3CL gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
EIF3CL for domains About GeneDecksing
3 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q99613ProtoNet protein and cluster: Q99613 2 Blocks protein families: IPB000717 Domain in components of the proteasome IPB008905 Eukaryotic translation initiation factor 3 subunit 8
UniProtKB/Swiss-Prot: EIF3C_HUMAN, Q99613Similarity: Belongs to the eIF-3 subunit C familySimilarity: Contains 1 PCI domain |
Function for EIF3CL gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
| Function Summary: UniProtKB/Swiss-Prot: EIF3C_HUMAN, Q99613Function: Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for severalsteps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and facilitates therecruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S preinitiation complex (43S PIC). TheeIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequentlyprevents premature joining of the 40S and 60S ribosomal subunits prior to initiation
Clone Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for EIF3CL OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for EIF3CL OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: EIF3CL (NM_001099661) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for EIF3CL | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat EIF3CL  |
In Situ Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for EIF3CL |
Gene Ontology (GO): 1 molecular function term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0003743 | translation initiation factor activity |
-- | -- |
EIF3CL for ontologies About GeneDecksing
|
Pathways & Interactions for EIF3CL gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
| Unified GeneCards pathways  About this table  See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | Synthesis of PB1-F2 | | | 2 | Translation initiation complex formation | | | 3 | Generic Transcription Pathway | | | 4 | Asparagine N-linked glycosylation | |
Pathway sources See GeneCards unified pathways Show all pathways
5/13
Reactome Pathways for EIF3CL (see all 13)
EIF3CL for pathways About GeneDecksing
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for EIF3CL
STRING Interaction
Network Preview (showing 5 interactants - click image to see 25)
 5/108 Interacting proteins for EIF3CL (Q996131, 2, 3 ENSP000003702584) via UniProtKB, MINT, STRING, and/or I2D (see all 108)About this table
|
Drugs & Compounds for EIF3CL gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
Browse Tocris compounds for EIF3CL Search CenterWatch for drugs/clinical trials and news about EIF3CL / EIF3C 
|
Transcripts for EIF3CL gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank, RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
) About This Section
| REFSEQ mRNAs for EIF3CL gene: NM_001099661.1 Unigene Cluster for EIF3CL: Eukaryotic translation initiation factor 3, subunit C-like Hs.535464 [show with all ESTs]Unigene Representative Sequence: NM_0010996613 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000380876(uc002dpi.4 uc010vcs.2) ENST00000398944(uc002dpf.4 uc010byb.3 uc010byc.3) ENST00000398943(uc002dpg.4 uc002dph.4)
Clone Products: |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for EIF3CL OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for EIF3CL OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: EIF3CL (NM_001099661) | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for EIF3CL | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat EIF3CL  |
24/98 DOTS entries (see all 98): DT.100657002 DT.92471241 DT.95213205 DT.91907929 DT.100686649 DT.100686656 DT.95260779 DT.120695606 DT.120695317 DT.120695406 DT.92027276 DT.92471231 DT.97856281 DT.120695506 DT.100686671 DT.100864539 DT.120696153 DT.120696055 DT.91801554 DT.100686647 DT.120695514 DT.120697900 DT.92404958 DT.100686659 GeneLoc Exon Structure
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Expression for EIF3CL gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| EIF3CL expression in normal human tissues (normalized intensities) See probesets specificity/sensitivity at GeneAnnot About this imageBioGPS CGAP TAG: --
About this image See EIF3CL Protein Expression from SPIRE MOPED and PaxDB Genevestigator expression for EIF3CL
SOURCE GeneReport for Unigene cluster: Hs.535464 SABiosciences Custom PCR Arrays for EIF3CL
Primer Products: |  | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for EIF3CL Browse OriGene validated miRNA SYBR primer pairs
| |  | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat EIF3CL | |  | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat EIF3CL | |  | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat EIF3CL | In Situ Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for EIF3CL |
Orthologs for EIF3CL gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of eukaryotes.
Orthologs for EIF3CL gene from 7/31 species (see all 31) About this table
ENSEMBL Gene Tree for EIF3CL (if available) TreeFam Gene Tree for EIF3CL (if available)  |
Paralogs for EIF3CL gene(Paralogs according to
1HomoloGene, 2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68) About This Section
| Paralogs for EIF3CL gene
- EIF3C1 2
1 SIMAP similar gene for EIF3CL using alignment to 2 protein entries: EIF3C_HUMAN (see all proteins):EIF3C
EIF3CL for paralogs About GeneDecksing
|
Genomic Variants for EIF3CL gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical significance | Chr 16 pos | Sequence | # | AA Chg | Type | More | # | Allele freq | Pop | Total sample | More |
|---|
HapMap Linkage Disequilibrium report for EIF3CL (28390900 - 28415200 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions) Database of Genomic Variants (DGV): 25 variations for EIF3CL 15/25 CNVs (see all 25): 88041 4937 72516 77252 3999 66972 72513 35381 88045 77254 30773 30772 88048 88043 30768  | SABiosciences Cancer Mutation PCR Assays |
|
Disorders
/ Diseases for EIF3CL gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
EIF3CL for disorders About GeneDecksing
2 diseases for EIF3CL: About MalaCardspolydactyly malaria Export disorders for EIF3CL gene to outside databases
|
Publications for EIF3CL gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for EIF3CL gene, integrated from 9 sources (see all 37): (articles sorted by number of sources associating them with EIF3CL) | |  | Utopia: connect your pdf to the dynamic world of online information |
- A quantitative atlas of mitotic phosphorylation. (PubMed id 18669648)1, 2 Dephoure N.... Gygi S.P. (2008)
- Mass spectrometry reveals modularity and a complete subunit interaction map of the eukaryotic translation factor eIF3. (PubMed id 18599441)1, 2 Zhou M....Robinson C.V. (2008)
- Reconstitution reveals the functional core of mammalian eIF3. (PubMed id 17581632)1, 2 Masutani M.... Imataka H. (2007)
- Structural characterization of the human eukaryotic initiation factor 3 protein complex by mass spectrometry. (PubMed id 17322308)1, 2 Damoc E....Leary J.A. (2007)
- Human INT6/eIF3e is required for nonsense-mediated mRNA decay. (PubMed id 17468741)1, 2 Morris C....Jalinot P. (2007)
- A probability-based approach for high-throughput protein phosphorylation analysis and site localization. (PubMed id 16964243)1, 2 Beausoleil S.A.... Gygi S.P. (2006)
- Translation initiation factor eIF4G-1 binds to eIF3 through the eIF3e subunit. (PubMed id 16766523)1, 2 LeFebvre A.K.... Rhoads R.E. (2006)
- Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)1, 2 Olsen J.V....Mann M. (2006)
- Binding of eukaryotic initiation factor 3 to ribosomal 40S subunits and its role in ribosomal dissociation and anti-association. (PubMed id 15703437)1, 2 Kolupaeva V.G....Pestova T.V. (2005)
- mTOR and S6K1 mediate assembly of the translation preinitiation complex through dynamic protein interchange and ordered phosphorylation events. (PubMed id 16286006)1, 2 Holz M.K.... Blenis J. (2005)
|
External Searches for EIF3CL gene
(in PubMed,
OMIM, and NCBI Bookshelf) About This Section
|
|
Genome Databases showing EIF3CL gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing EIF3CL gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing EIF3CL gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL, Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot) About This Section
|
|
About This Section
| Patent Information for EIF3CL gene: Search GeneIP for patents involving EIF3CL
GeneCards and IP: Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products for EIF3CL gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences), In Situ Hybridization Assays from Advanced Cell Diagnostics About This Section
|
 | |
 | |
 |
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 | | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for EIF3CL |
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| | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat EIF3CL |
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