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Aliases for EIF3CL Gene

Aliases for EIF3CL Gene

  • Eukaryotic Translation Initiation Factor 3 Subunit C-Like 2 3 5
  • Eukaryotic Translation Initiation Factor 3, Subunit C-Like 2

External Ids for EIF3CL Gene

Previous GeneCards Identifiers for EIF3CL Gene

  • GC16M028299

Summaries for EIF3CL Gene

Entrez Gene Summary for EIF3CL Gene

  • The protein encoded by this gene is a core subunit of the eukaryotic translation initiation factor 3 (eIF3) complex. The encoded protein is nearly identical to another protein, eIF3c, from a related gene. The eIF3 complex binds the 40S ribosome and mRNAs to enable translation initiation. Several transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Dec 2015]

GeneCards Summary for EIF3CL Gene

EIF3CL (Eukaryotic Translation Initiation Factor 3 Subunit C-Like) is a Protein Coding gene. Among its related pathways are Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S and Viral mRNA Translation. GO annotations related to this gene include translation initiation factor activity and translation initiation factor binding. An important paralog of this gene is EIF3C.

UniProtKB/Swiss-Prot for EIF3CL Gene

  • Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, including cell cycling, differentiation and apoptosis, and uses different modes of RNA stem-loop binding to exert either translational activation or repression.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for EIF3CL Gene

Genomics for EIF3CL Gene

Regulatory Elements for EIF3CL Gene

Enhancers for EIF3CL Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH16F028861 1.2 ENCODE 18.9 -460.7 -460742 5.6 HDGF ARNT CREB3L1 ZFP64 ARID4B SIN3A DMAP1 YY1 CBX5 ZNF207 TUFM ENSG00000260853 MIR4517 SMG1P2 ENSG00000260367 SULT1A2 EIF3CL ENSG00000261766 SGF29 NUPR1
GH16F028973 1.2 ENCODE 10.6 -570.8 -570843 2.4 PKNOX1 CREB3L1 MLX ARID4B SIN3A FEZF1 DMAP1 ZNF2 YY1 SLC30A9 MIR4517 NUPR1 ENSG00000260853 SMG1P2 SGF29 SULT1A2 ENSG00000260367 NFATC2IP RABEP2 CD19
GH16F029028 1.2 Ensembl ENCODE 10 -625.4 -625437 1.4 ZNF121 GTF3C2 GLIS2 FOS NCOA1 JUNB MBD2 SMARCA4 GLIS1 MYNN ENSG00000260853 MIR4517 ENSG00000260367 SMG1P2 EIF3CL NPIPB10P GC16M028992
GH16F027429 1.2 Ensembl ENCODE 10 +972.2 972244 3.3 HDAC1 PKNOX1 CBX3 ARNT TBL1XR1 GTF3C2 EGR1 GATA2 ZNF143 CREM IL21R KDM8 XPO6 EIF3CL IL21R-AS1
GH16F028950 1.1 ENCODE 10.3 -547.4 -547441 2.4 HDGF PKNOX1 CREB3L1 ARID4B SIN3A ZNF2 YY1 ZNF143 FOS CEBPZ SULT1A2 NUPR1 SMG1P2 SGF29 XPO6 MIR4517 EIF3CL APOBR C16orf54 KCTD13
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around EIF3CL on UCSC Golden Path with GeneCards custom track

Promoters for EIF3CL Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001800704 279 1601

Genomic Location for EIF3CL Gene

Chromosome:
16
Start:
28,379,579 bp from pter
End:
28,403,879 bp from pter
Size:
24,301 bases
Orientation:
Minus strand

Genomic View for EIF3CL Gene

Genes around EIF3CL on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
EIF3CL Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for EIF3CL Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for EIF3CL Gene

Proteins for EIF3CL Gene

  • Protein details for EIF3CL Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    B5ME19-EIFCL_HUMAN
    Recommended name:
    Eukaryotic translation initiation factor 3 subunit C-like protein
    Protein Accession:
    B5ME19

    Protein attributes for EIF3CL Gene

    Size:
    914 amino acids
    Molecular mass:
    105473 Da
    Quaternary structure:
    • Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is composed of 13 subunits: EIF3A, EIF3B, EIF3C, EIF3D, EIF3E, EIF3F, EIF3G, EIF3H, EIF3I, EIF3J, EIF3K, EIF3L and EIF3M. The eIF-3 complex appears to include 3 stable modules: module A is composed of EIF3A, EIF3B, EIF3G and EIF3I; module B is composed of EIF3F, EIF3H, and EIF3M; and module C is composed of EIF3C, EIF3D, EIF3E, EIF3K and EIF3L. EIF3C of module C binds EIF3B of module A and EIF3H of module B, thereby linking the three modules. EIF3J is a labile subunit that binds to the eIF-3 complex via EIF3B. The eIF-3 complex interacts with RPS6KB1 under conditions of nutrient depletion. Mitogenic stimulation leads to binding and activation of a complex composed of MTOR and RPTOR, leading to phosphorylation and release of RPS6KB1 and binding of EIF4B to eIF-3 (By similarity).

neXtProt entry for EIF3CL Gene

Post-translational modifications for EIF3CL Gene

  • Phosphorylated. Phosphorylation is enhanced upon serum stimulation (By similarity).
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for EIF3CL Gene

No data available for DME Specific Peptides for EIF3CL Gene

Domains & Families for EIF3CL Gene

Protein Domains for EIF3CL Gene

Suggested Antigen Peptide Sequences for EIF3CL Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

B5ME19

UniProtKB/Swiss-Prot:

EIFCL_HUMAN :
  • Contains 1 PCI domain.
  • Belongs to the eIF-3 subunit C family.
Domain:
  • Contains 1 PCI domain.
Family:
  • Belongs to the eIF-3 subunit C family.
genes like me logo Genes that share domains with EIF3CL: view

No data available for Gene Families for EIF3CL Gene

Function for EIF3CL Gene

Molecular function for EIF3CL Gene

UniProtKB/Swiss-Prot Function:
Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, including cell cycling, differentiation and apoptosis, and uses different modes of RNA stem-loop binding to exert either translational activation or repression.

Gene Ontology (GO) - Molecular Function for EIF3CL Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003723 RNA binding IEA --
GO:0003743 contributes_to translation initiation factor activity IBA --
GO:0031369 translation initiation factor binding IEA,IBA --
genes like me logo Genes that share ontologies with EIF3CL: view

Phenotypes for EIF3CL Gene

GenomeRNAi human phenotypes for EIF3CL:
genes like me logo Genes that share phenotypes with EIF3CL: view

Animal Model Products

miRNA for EIF3CL Gene

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for EIF3CL Gene

Localization for EIF3CL Gene

Subcellular locations from UniProtKB/Swiss-Prot for EIF3CL Gene

Cytoplasm.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for EIF3CL gene
Compartment Confidence
nucleus 2
cytosol 2

Gene Ontology (GO) - Cellular Components for EIF3CL Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
GO:0005852 eukaryotic translation initiation factor 3 complex IEA,IBA --
GO:0016282 eukaryotic 43S preinitiation complex IEA --
GO:0033290 eukaryotic 48S preinitiation complex IEA --
genes like me logo Genes that share ontologies with EIF3CL: view

Pathways & Interactions for EIF3CL Gene

genes like me logo Genes that share pathways with EIF3CL: view

Gene Ontology (GO) - Biological Process for EIF3CL Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006412 translation IEA --
GO:0006413 translational initiation IEA,IBA --
GO:0006446 regulation of translational initiation IEA --
genes like me logo Genes that share ontologies with EIF3CL: view

No data available for SIGNOR curated interactions for EIF3CL Gene

Transcripts for EIF3CL Gene

mRNA/cDNA for EIF3CL Gene

(5) REFSEQ mRNAs :
(0) Additional mRNA sequences :
-
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for EIF3CL Gene

Eukaryotic translation initiation factor 3, subunit C-like:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for EIF3CL Gene

No ASD Table

Relevant External Links for EIF3CL Gene

GeneLoc Exon Structure for
EIF3CL
ECgene alternative splicing isoforms for
EIF3CL

Expression for EIF3CL Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for EIF3CL Gene

Protein differential expression in normal tissues from HIPED for EIF3CL Gene

This gene is overexpressed in Lymph node (7.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for EIF3CL Gene



Protein tissue co-expression partners for EIF3CL Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of EIF3CL Gene:

EIF3CL

SOURCE GeneReport for Unigene cluster for EIF3CL Gene:

Hs.535464
genes like me logo Genes that share expression patterns with EIF3CL: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for EIF3CL Gene

Orthologs for EIF3CL Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for EIF3CL Gene

Organism Taxonomy Gene Similarity Type Details
dog
(Canis familiaris)
Mammalia -- 35
  • 99 (a)
OneToMany
chimpanzee
(Pan troglodytes)
Mammalia -- 35
  • 99 (a)
OneToMany
cow
(Bos Taurus)
Mammalia EIF3C 35
  • 98 (a)
OneToMany
mouse
(Mus musculus)
Mammalia Eif3c 35
  • 97 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia -- 35
  • 96 (a)
ManyToMany
-- 35
  • 93 (a)
ManyToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 91 (a)
OneToMany
chicken
(Gallus gallus)
Aves -- 35
  • 87 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 35
  • 87 (a)
OneToMany
zebrafish
(Danio rerio)
Actinopterygii eif3c 35
  • 74 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta eIF3-S8 35
  • 52 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea eif-3.C 35
  • 42 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes NIP1 35 37
  • 25 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 55 (a)
OneToMany
Species where no ortholog for EIF3CL was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for EIF3CL Gene

ENSEMBL:
Gene Tree for EIF3CL (if available)
TreeFam:
Gene Tree for EIF3CL (if available)

Paralogs for EIF3CL Gene

Paralogs for EIF3CL Gene

(1) SIMAP similar genes for EIF3CL Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with EIF3CL: view

Variants for EIF3CL Gene

Sequence variations from dbSNP and Humsavar for EIF3CL Gene

SNP ID Clin Chr 16 pos Sequence Context AA Info Type
rs111292448 -- 28,387,491(+) CAGGA(A/G)TGTAA intron-variant
rs111589636 -- 28,392,849(+) AAATT(A/C)TGAAT intron-variant, upstream-variant-2KB
rs111746157 -- 28,404,490(+) TCGAG(A/C)CCAGC upstream-variant-2KB
rs111919466 -- 28,391,858(-) TGATA(A/C/G/T)AGGAG intron-variant, upstream-variant-2KB
rs112236388 -- 28,393,556(+) AACTA(A/T)AGCTA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for EIF3CL Gene

Variant ID Type Subtype PubMed ID
nsv984299 CNV duplication 23825009
nsv984297 CNV duplication 23825009
nsv977947 CNV duplication 23825009
nsv952962 CNV deletion 24416366
nsv9419 CNV gain+loss 18304495
nsv9414 CNV gain+loss 18304495
nsv833180 CNV loss 17160897
nsv821114 CNV deletion 20802225
nsv571783 CNV loss 21841781
nsv571780 CNV loss 21841781
nsv571724 CNV loss 21841781
nsv511572 CNV loss 21212237
nsv510683 CNV deletion 20534489
nsv1776 CNV deletion 18451855
nsv1124734 CNV duplication 24896259
nsv1115498 CNV duplication 24896259
nsv1066415 CNV gain 25217958
nsv1064483 CNV loss 25217958
nsv1059555 CNV gain 25217958
esv999954 CNV loss 20482838
esv3892824 CNV loss 25118596
esv2920457 CNV deletion 24192839
esv2758640 CNV gain+loss 17122850
esv25666 CNV gain+loss 19812545
esv23667 CNV gain+loss 19812545
dgv813e212 CNV loss 25503493
dgv4967n54 CNV loss 21841781
dgv4966n54 CNV loss 21841781
dgv4965n54 CNV loss 21841781
dgv4964n54 CNV loss 21841781
dgv2830n100 CNV gain 25217958
dgv13n14 CNV gain 18776910

Variation tolerance for EIF3CL Gene

Gene Damage Index Score: 4.77; 66.66% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for EIF3CL Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
EIF3CL

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for EIF3CL Gene

Disorders for EIF3CL Gene

Relevant External Links for EIF3CL

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
EIF3CL

No disorders were found for EIF3CL Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for EIF3CL Gene

Publications for EIF3CL Gene

  1. Quantitative Proteomics Reveals Dynamic Interactions of the Minichromosome Maintenance Complex (MCM) in the Cellular Response to Etoposide Induced DNA Damage. (PMID: 25963833) Drissi R. … Boisvert F.M. (Mol. Cell Proteomics 2015) 3 64
  2. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3 64
  3. Panorama of ancient metazoan macromolecular complexes. (PMID: 26344197) Wan C. … Emili A. (Nature 2015) 3 64
  4. Common genetic variants associated with cognitive performance identified using the proxy-phenotype method. (PMID: 25201988) Rietveld C.A. … Koellinger P.D. (Proc. Natl. Acad. Sci. U.S.A. 2014) 3 64
  5. The intracellular interactome of tetraspanin-enriched microdomains reveals their function as sorting machineries toward exosomes. (PMID: 23463506) Perez-Hernandez D. … YA!A+ez-MA^ M. (J. Biol. Chem. 2013) 3 64

Products for EIF3CL Gene

Sources for EIF3CL Gene

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