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Aliases for EIF3C Gene

Aliases for EIF3C Gene

  • Eukaryotic Translation Initiation Factor 3 Subunit C 2 3 5
  • Eukaryotic Translation Initiation Factor 3, Subunit 8, 110kDa 2 3
  • Eukaryotic Translation Initiation Factor 3 Subunit 8 3 4
  • EIF3 P110 3 4
  • EIF3S8 3 4
  • Eukaryotic Translation Initiation Factor 3, Subunit 8 (110kD) 3
  • Eukaryotic Translation Initiation Factor 3, Subunit C 2
  • Cell Migration-Inducing Protein 17 3
  • EIF3-P110 3
  • EIF3CL 3
  • EIF3c 4

External Ids for EIF3C Gene

Previous HGNC Symbols for EIF3C Gene

  • EIF3S8

Previous GeneCards Identifiers for EIF3C Gene

  • GC16P028631
  • GC16P028723
  • GC16M026450

Summaries for EIF3C Gene

GeneCards Summary for EIF3C Gene

EIF3C (Eukaryotic Translation Initiation Factor 3 Subunit C) is a Protein Coding gene. Among its related pathways are Viral mRNA Translation and Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S. GO annotations related to this gene include poly(A) RNA binding and translation initiation factor activity. An important paralog of this gene is EIF3CL.

UniProtKB/Swiss-Prot for EIF3C Gene

  • Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis (PubMed:17581632, PubMed:25849773, PubMed:27462815). The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation (PubMed:17581632). The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, including cell cycling, differentiation and apoptosis, and uses different modes of RNA stem-loop binding to exert either translational activation or repression (PubMed:25849773).

Gene Wiki entry for EIF3C Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for EIF3C Gene

Genomics for EIF3C Gene

Regulatory Elements for EIF3C Gene

Enhancers for EIF3C Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH16G028308 1.2 Ensembl ENCODE 6.2 -377.6 -377642 5.8 FOXA2 ZNF121 ZNF143 FOS SP5 MIER2 REST ZNF579 NFIL3 SSRP1 EIF3C NFATC2IP CDC37P1 GC16P028319 ENSG00000246465
GH16G028292 1.1 ENCODE 5.6 -395.8 -395794 2.5 HDGF PKNOX1 MLX ZFP64 ARID4B SIN3A ZNF2 SLC30A9 ZNF766 ZNF143 NPIPB7 SULT1A2 NPIPB9 NPIPB6 EIF3C CDC37P1 ENSG00000246465 GC16P028319
GH16G028930 1.4 Ensembl ENCODE dbSUPER 4.2 +243.2 243221 3.5 PKNOX1 YBX1 BMI1 ZNF48 EGR1 ZNF143 RELB IKZF2 ZBTB11 ZNF426 TUFM SULT1A2 CDC37P1 KCTD13 EIF3C SMG1P2 CD19 GC16P028929
GH16G028324 0.9 ENCODE 4.4 -363.8 -363806 1.2 ELF3 FOXA2 DNMT3B ZNF121 FOS MIXL1 THAP11 SP5 CEBPB SSRP1 ENSG00000246465 SBK1 GSG1L EIF3C GC16P028321 ENSG00000277191
GH16G028531 1.5 FANTOM5 Ensembl ENCODE 2.5 -154.9 -154903 3.7 ELF3 CBX3 ARID4B RAD21 RARA YY1 ZNF121 ZNF366 IKZF2 MIXL1 SULT1A2 TUFM APOBR SGF29 NPIPB7 CLN3 IL27 ENSG00000251417 SULT1A1 SPNS1
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around EIF3C on UCSC Golden Path with GeneCards custom track

Promoters for EIF3C Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000084922 142 601

Genomic Location for EIF3C Gene

Chromosome:
16
Start:
28,688,558 bp from pter
End:
28,735,730 bp from pter
Size:
47,173 bases
Orientation:
Plus strand

Genomic View for EIF3C Gene

Genes around EIF3C on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
EIF3C Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for EIF3C Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for EIF3C Gene

Proteins for EIF3C Gene

  • Protein details for EIF3C Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q99613-EIF3C_HUMAN
    Recommended name:
    Eukaryotic translation initiation factor 3 subunit C
    Protein Accession:
    Q99613
    Secondary Accessions:
    • A8K7Z0
    • B2RXG3
    • B4E1D5
    • H3BRV0
    • O00215
    • Q9BW98

    Protein attributes for EIF3C Gene

    Size:
    913 amino acids
    Molecular mass:
    105344 Da
    Quaternary structure:
    • Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is composed of 13 subunits: EIF3A, EIF3B, EIF3C, EIF3D, EIF3E, EIF3F, EIF3G, EIF3H, EIF3I, EIF3J, EIF3K, EIF3L and EIF3M. The eIF-3 complex appears to include 3 stable modules: module A is composed of EIF3A, EIF3B, EIF3G and EIF3I; module B is composed of EIF3F, EIF3H, and EIF3M; and module C is composed of EIF3C, EIF3D, EIF3E, EIF3K and EIF3L. EIF3C of module C binds EIF3B of module A and EIF3H of module B, thereby linking the three modules. EIF3J is a labile subunit that binds to the eIF-3 complex via EIF3B. The eIF-3 complex interacts with RPS6KB1 under conditions of nutrient depletion. Mitogenic stimulation leads to binding and activation of a complex composed of MTOR and RPTOR, leading to phosphorylation and release of RPS6KB1 and binding of EIF4B to eIF-3. Identified in a HCV IRES-mediated translation complex, at least composed of EIF3C, IGF2BP1, RPS3 and HCV RNA-replicon. Interacts with ALKBH4, IFIT1 and IFIT2.

    Three dimensional structures from OCA and Proteopedia for EIF3C Gene

    Alternative splice isoforms for EIF3C Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for EIF3C Gene

Post-translational modifications for EIF3C Gene

  • Phosphorylated. Phosphorylation is enhanced upon serum stimulation.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for EIF3C Gene

Domains & Families for EIF3C Gene

Gene Families for EIF3C Gene

Graphical View of Domain Structure for InterPro Entry

Q99613

UniProtKB/Swiss-Prot:

EIF3C_HUMAN :
  • Belongs to the eIF-3 subunit C family.
Family:
  • Belongs to the eIF-3 subunit C family.
genes like me logo Genes that share domains with EIF3C: view

Function for EIF3C Gene

Molecular function for EIF3C Gene

UniProtKB/Swiss-Prot Function:
Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis (PubMed:17581632, PubMed:25849773, PubMed:27462815). The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation (PubMed:17581632). The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, including cell cycling, differentiation and apoptosis, and uses different modes of RNA stem-loop binding to exert either translational activation or repression (PubMed:25849773).

Gene Ontology (GO) - Molecular Function for EIF3C Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003723 RNA binding IDA 22658674
GO:0003743 contributes_to translation initiation factor activity IDA 17581632
GO:0005515 protein binding IPI 18628297
GO:0031369 translation initiation factor binding IBA --
genes like me logo Genes that share ontologies with EIF3C: view
genes like me logo Genes that share phenotypes with EIF3C: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for EIF3C Gene

Localization for EIF3C Gene

Subcellular locations from UniProtKB/Swiss-Prot for EIF3C Gene

Cytoplasm.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for EIF3C gene
Compartment Confidence
cytosol 5
nucleus 2

Gene Ontology (GO) - Cellular Components for EIF3C Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
GO:0005829 cytosol TAS --
GO:0005852 eukaryotic translation initiation factor 3 complex IDA 17322308
GO:0016282 eukaryotic 43S preinitiation complex IEA --
GO:0033290 eukaryotic 48S preinitiation complex IEA --
genes like me logo Genes that share ontologies with EIF3C: view

Pathways & Interactions for EIF3C Gene

genes like me logo Genes that share pathways with EIF3C: view

Gene Ontology (GO) - Biological Process for EIF3C Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006412 translation IEA --
GO:0006413 translational initiation TAS --
GO:0006446 regulation of translational initiation IEA --
GO:0045727 positive regulation of translation IPI 24092755
GO:1902416 positive regulation of mRNA binding IPI 24092755
genes like me logo Genes that share ontologies with EIF3C: view

No data available for SIGNOR curated interactions for EIF3C Gene

Drugs & Compounds for EIF3C Gene

No Compound Related Data Available

Transcripts for EIF3C Gene

Unigene Clusters for EIF3C Gene

Eukaryotic translation initiation factor 3, subunit C:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for EIF3C Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3 ^ 4 ^ 5a · 5b · 5c ^ 6a · 6b ^ 7 ^ 8 ^ 9a · 9b ^ 10 ^ 11 ^ 12a · 12b · 12c · 12d ^ 13 ^ 14a · 14b · 14c ^
SP1: - - - - -
SP2: - - - - - - -
SP3: - - -
SP4:
SP5: - - - - - - - - - - - - - - - - - - - -
SP6:
SP7: - - - - - - - -
SP8: - -
SP9:
SP10:
SP11:
SP12: - -
SP13: -
SP14:

ExUns: 15a · 15b ^ 16 ^ 17a · 17b ^ 18a · 18b · 18c ^ 19a · 19b · 19c ^ 20 ^ 21a · 21b ^ 22 ^ 23a · 23b ^ 24a · 24b
SP1:
SP2:
SP3:
SP4:
SP5: - - - - - -
SP6:
SP7:
SP8:
SP9: - - -
SP10: - - - - - -
SP11:
SP12:
SP13:
SP14:

Relevant External Links for EIF3C Gene

GeneLoc Exon Structure for
EIF3C
ECgene alternative splicing isoforms for
EIF3C

Expression for EIF3C Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for EIF3C Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for EIF3C Gene

This gene is overexpressed in Lymph node (7.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for EIF3C Gene



Protein tissue co-expression partners for EIF3C Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of EIF3C Gene:

EIF3C

SOURCE GeneReport for Unigene cluster for EIF3C Gene:

Hs.567374

Evidence on tissue expression from TISSUES for EIF3C Gene

  • Nervous system(5)
  • Liver(4.7)
  • Skin(4.6)
  • Lung(4.3)
  • Intestine(4.1)
  • Eye(3.9)
  • Kidney(3.9)
  • Pancreas(3.8)
  • Muscle(3.3)
  • Blood(3.1)
  • Heart(2.9)
  • Stomach(2.9)
  • Spleen(2.2)
  • Thyroid gland(2)
genes like me logo Genes that share expression patterns with EIF3C: view

Primer Products

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for EIF3C Gene

Orthologs for EIF3C Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for EIF3C Gene

Organism Taxonomy Gene Similarity Type Details
dog
(Canis familiaris)
Mammalia -- 35
  • 99 (a)
OneToMany
EIF3C 34
  • 91.75 (n)
chimpanzee
(Pan troglodytes)
Mammalia -- 35
  • 99 (a)
OneToMany
cow
(Bos Taurus)
Mammalia EIF3C 35
  • 98 (a)
OneToMany
EIF3CL 34
  • 91.81 (n)
oppossum
(Monodelphis domestica)
Mammalia -- 35
  • 96 (a)
ManyToMany
-- 35
  • 93 (a)
ManyToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 91 (a)
OneToMany
mouse
(Mus musculus)
Mammalia Eif3c 16 35 34
  • 89.24 (n)
rat
(Rattus norvegicus)
Mammalia Eif3c 34
  • 89.1 (n)
chicken
(Gallus gallus)
Aves -- 35
  • 87 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 35
  • 87 (a)
OneToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia eif3c 34
  • 74.71 (n)
MGC75608 34
African clawed frog
(Xenopus laevis)
Amphibia Xl.7935 34
zebrafish
(Danio rerio)
Actinopterygii eif3c 35 34
  • 73.28 (n)
OneToMany
Dr.28312 34
fruit fly
(Drosophila melanogaster)
Insecta eIF3-S8 34 35
  • 60.38 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta EIF3C_ANOGA 34
  • 57.38 (n)
worm
(Caenorhabditis elegans)
Secernentea eif-3.C 34 35
  • 52.56 (n)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AGL344C 34
  • 46.21 (n)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0F03014g 34
  • 44.53 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes NIP1 35 37 34
  • 43.45 (n)
OneToMany
thale cress
(Arabidopsis thaliana)
eudicotyledons EIF3C 34
  • 52.75 (n)
rice
(Oryza sativa)
Liliopsida Os07g0124500 34
  • 51.08 (n)
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 55 (a)
OneToMany
bread mold
(Neurospora crassa)
Ascomycetes NCU07831 34
  • 53.55 (n)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes tif33 34
  • 49.02 (n)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.3491 34
Species where no ortholog for EIF3C was found in the sources mined by GeneCards:
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for EIF3C Gene

ENSEMBL:
Gene Tree for EIF3C (if available)
TreeFam:
Gene Tree for EIF3C (if available)

Paralogs for EIF3C Gene

Paralogs for EIF3C Gene

genes like me logo Genes that share paralogs with EIF3C: view

Variants for EIF3C Gene

Sequence variations from dbSNP and Humsavar for EIF3C Gene

SNP ID Clin Chr 16 pos Sequence Context AA Info Type
rs1000487710 -- 28,710,493(+) ACCAC(C/T)TTGAA intron-variant, upstream-variant-2KB
rs1001092220 -- 28,694,722(+) ATTAG(C/T)TGGGC intron-variant
rs1001253504 -- 28,692,755(+) ACTCC(G/T)TCTCA intron-variant
rs1001347881 -- 28,703,175(+) CTATA(C/T)TAGTA intron-variant
rs1001465565 -- 28,700,619(+) CGCAG(-/C)CCCGC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for EIF3C Gene

Variant ID Type Subtype PubMed ID
dgv13n14 CNV gain 18776910
dgv2830n100 CNV gain 25217958
dgv4964n54 CNV loss 21841781
dgv4965n54 CNV loss 21841781
dgv4966n54 CNV loss 21841781
dgv4967n54 CNV loss 21841781
dgv4968n54 CNV loss 21841781
dgv4969n54 CNV loss 21841781
dgv4970n54 CNV loss 21841781
dgv4972n54 CNV loss 21841781
dgv4982n54 CNV loss 21841781
dgv813e212 CNV loss 25503493
esv23667 CNV gain+loss 19812545
esv25666 CNV gain+loss 19812545
esv2758640 CNV gain+loss 17122850
esv2920457 CNV deletion 24192839
esv2921568 CNV deletion 24192839
esv3892824 CNV loss 25118596
esv999954 CNV loss 20482838
nsv1059555 CNV gain 25217958
nsv1064483 CNV loss 25217958
nsv1066415 CNV gain 25217958
nsv1069937 CNV deletion 25765185
nsv1071282 CNV deletion 25765185
nsv1115498 CNV duplication 24896259
nsv1124734 CNV duplication 24896259
nsv1776 CNV deletion 18451855
nsv510683 CNV deletion 20534489
nsv511572 CNV loss 21212237
nsv571724 CNV loss 21841781
nsv571755 CNV gain 21841781
nsv571780 CNV loss 21841781
nsv571783 CNV loss 21841781
nsv571784 CNV loss 21841781
nsv571787 CNV loss 21841781
nsv820432 CNV deletion 20802225
nsv821114 CNV deletion 20802225
nsv833180 CNV loss 17160897
nsv9414 CNV gain+loss 18304495
nsv9419 CNV gain+loss 18304495
nsv952962 CNV deletion 24416366
nsv977947 CNV duplication 23825009
nsv984297 CNV duplication 23825009
nsv984299 CNV duplication 23825009

Variation tolerance for EIF3C Gene

Gene Damage Index Score: 0.30; 6.75% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for EIF3C Gene

Human Gene Mutation Database (HGMD)
EIF3C
SNPedia medical, phenotypic, and genealogical associations of SNPs for
EIF3C

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for EIF3C Gene

Disorders for EIF3C Gene

Relevant External Links for EIF3C

Genetic Association Database (GAD)
EIF3C
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
EIF3C

No disorders were found for EIF3C Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for EIF3C Gene

Publications for EIF3C Gene

  1. Conservation and diversity of eukaryotic translation initiation factor eIF3. (PMID: 8995409) Asano K. … Hershey J.W.B. (J. Biol. Chem. 1997) 2 3 4 64
  2. eIF3 targets cell-proliferation messenger RNAs for translational activation or repression. (PMID: 25849773) Lee A.S. … Cate J.H. (Nature 2015) 3 4 64
  3. Common variants at five new loci associated with early-onset inflammatory bowel disease. (PMID: 19915574) Imielinski M. … Hakonarson H. (Nat. Genet. 2009) 3 46 64
  4. Mass spectrometry reveals modularity and a complete subunit interaction map of the eukaryotic translation factor eIF3. (PMID: 18599441) Zhou M. … Robinson C.V. (Proc. Natl. Acad. Sci. U.S.A. 2008) 3 4 64
  5. Reconstitution reveals the functional core of mammalian eIF3. (PMID: 17581632) Masutani M. … Imataka H. (EMBO J. 2007) 3 4 64

Products for EIF3C Gene

Sources for EIF3C Gene

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