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Aliases for EIF3C Gene

Aliases for EIF3C Gene

  • Eukaryotic Translation Initiation Factor 3, Subunit C 2 3
  • EIF3S8 3 4 6
  • Eukaryotic Translation Initiation Factor 3, Subunit 8, 110kDa 2 3
  • Eukaryotic Translation Initiation Factor 3 Subunit 8 3 4
  • EIF3 P110 3 4
  • Eukaryotic Translation Initiation Factor 3, Subunit 8 (110kD) 3
  • Eukaryotic Translation Initiation Factor 3 Subunit C 3
  • Cell Migration-Inducing Protein 17 3
  • EIF3-P110 3
  • EIF3CL 3
  • EIF3c 4

External Ids for EIF3C Gene

Previous HGNC Symbols for EIF3C Gene

  • EIF3S8

Previous GeneCards Identifiers for EIF3C Gene

  • GC16P028631
  • GC16P028723
  • GC16M026450

Summaries for EIF3C Gene

GeneCards Summary for EIF3C Gene

EIF3C (Eukaryotic Translation Initiation Factor 3, Subunit C) is a Protein Coding gene. Among its related pathways are p70S6K Signaling and Apoptotic Pathways in Synovial Fibroblasts. GO annotations related to this gene include translation initiation factor activity and translation initiation factor binding.

UniProtKB/Swiss-Prot for EIF3C Gene

  • Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S preinitiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation

Gene Wiki entry for EIF3C Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for EIF3C Gene

Genomics for EIF3C Gene

Regulatory Elements for EIF3C Gene

Genomic Location for EIF3C Gene

Start:
28,688,558 bp from pter
End:
28,735,730 bp from pter
Size:
47,173 bases
Orientation:
Plus strand

Genomic View for EIF3C Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for EIF3C Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for EIF3C Gene

Proteins for EIF3C Gene

  • Protein details for EIF3C Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q99613-EIF3C_HUMAN
    Recommended name:
    Eukaryotic translation initiation factor 3 subunit C
    Protein Accession:
    Q99613
    Secondary Accessions:
    • A8K7Z0
    • B2RXG3
    • B4E1D5
    • H3BRV0
    • O00215
    • Q9BW98

    Protein attributes for EIF3C Gene

    Size:
    913 amino acids
    Molecular mass:
    105344 Da
    Quaternary structure:
    • Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is composed of 13 subunits: EIF3A, EIF3B, EIF3C, EIF3D, EIF3E, EIF3F, EIF3G, EIF3H, EIF3I, EIF3J, EIF3K, EIF3L and EIF3M. The eIF-3 complex appears to include 3 stable modules: module A is composed of EIF3A, EIF3B, EIF3G and EIF3I; module B is composed of EIF3F, EIF3H, and EIF3M; and module C is composed of EIF3C, EIF3D, EIF3E, EIF3K and EIF3L. EIF3C of module C binds EIF3B of module A and EIF3H of module B, thereby linking the three modules. EIF3J is a labile subunit that binds to the eIF-3 complex via EIF3B. The eIF-3 complex interacts with RPS6KB1 under conditions of nutrient depletion. Mitogenic stimulation leads to binding and activation of a complex composed of MTOR and RPTOR, leading to phosphorylation and release of RPS6KB1 and binding of EIF4B to eIF-3. Identified in a HCV IRES-mediated translation complex, at least composed of EIF3C, IGF2BP1, RPS3 and HCV RNA-replicon. Interacts with ALKBH4, IFIT1 and IFIT2.

    Three dimensional structures from OCA and Proteopedia for EIF3C Gene

    Alternative splice isoforms for EIF3C Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for EIF3C Gene

Proteomics data for EIF3C Gene at MOPED

Post-translational modifications for EIF3C Gene

  • Phosphorylated. Phosphorylation is enhanced upon serum stimulation.
  • Ubiquitination at Lys493, Lys643, Lys712, Lys742, Lys760, Lys862, Lys877, and Lys894
  • Modification sites at PhosphoSitePlus

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for EIF3C (eIF3C)

No data available for DME Specific Peptides for EIF3C Gene

Domains for EIF3C Gene

Graphical View of Domain Structure for InterPro Entry

Q99613

UniProtKB/Swiss-Prot:

EIF3C_HUMAN :
  • Q99613
Domain:
  • Contains 1 PCI domain.
Family:
  • Belongs to the eIF-3 subunit C family.
genes like me logo Genes that share domains with EIF3C: view

No data available for Gene Families for EIF3C Gene

Function for EIF3C Gene

Molecular function for EIF3C Gene

UniProtKB/Swiss-Prot Function: Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S preinitiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation

Gene Ontology (GO) - Molecular Function for EIF3C Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003743 contributes_to translation initiation factor activity IDA 17581632
GO:0005488 binding --
GO:0005515 protein binding IPI 18628297
GO:0031369 translation initiation factor binding IEA --
GO:0044822 poly(A) RNA binding IDA 22658674
genes like me logo Genes that share ontologies with EIF3C: view
genes like me logo Genes that share phenotypes with EIF3C: view

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for EIF3C Gene

Localization for EIF3C Gene

Subcellular locations from UniProtKB/Swiss-Prot for EIF3C Gene

Cytoplasm.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for EIF3C Gene COMPARTMENTS Subcellular localization image for EIF3C gene
Compartment Confidence
cytosol 4
nucleus 2

Gene Ontology (GO) - Cellular Components for EIF3C Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005829 cytosol TAS --
GO:0005852 eukaryotic translation initiation factor 3 complex IDA 17322308
GO:0016282 eukaryotic 43S preinitiation complex IEA --
GO:0033290 eukaryotic 48S preinitiation complex IEA --
genes like me logo Genes that share ontologies with EIF3C: view

Pathways for EIF3C Gene

genes like me logo Genes that share pathways with EIF3C: view

Pathways by source for EIF3C Gene

2 Qiagen pathways for EIF3C Gene
1 Cell Signaling Technology pathway for EIF3C Gene
1 BioSystems pathway for EIF3C Gene

Gene Ontology (GO) - Biological Process for EIF3C Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001731 formation of translation preinitiation complex IEA --
GO:0006412 translation TAS --
GO:0006413 translational initiation TAS --
GO:0006446 regulation of translational initiation IEA --
GO:0010467 gene expression TAS --
genes like me logo Genes that share ontologies with EIF3C: view

Transcripts for EIF3C Gene

Unigene Clusters for EIF3C Gene

Eukaryotic translation initiation factor 3, subunit C:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for EIF3C

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for EIF3C Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3 ^ 4 ^ 5a · 5b · 5c ^ 6a · 6b ^ 7 ^ 8 ^ 9a · 9b ^ 10 ^ 11 ^ 12a · 12b · 12c · 12d ^ 13 ^ 14a · 14b · 14c ^
SP1: - - - - -
SP2: - - - - - - -
SP3: - - -
SP4:
SP5: - - - - - - - - - - - - - - - - - - - -
SP6:
SP7: - - - - - - - -
SP8: - -
SP9:
SP10:
SP11:
SP12: - -
SP13: -
SP14:

ExUns: 15a · 15b ^ 16 ^ 17a · 17b ^ 18a · 18b · 18c ^ 19a · 19b · 19c ^ 20 ^ 21a · 21b ^ 22 ^ 23a · 23b ^ 24a · 24b
SP1:
SP2:
SP3:
SP4:
SP5: - - - - - -
SP6:
SP7:
SP8:
SP9: - - -
SP10: - - - - - -
SP11:
SP12:
SP13:
SP14:

Relevant External Links for EIF3C Gene

GeneLoc Exon Structure for
EIF3C
ECgene alternative splicing isoforms for
EIF3C

Expression for EIF3C Gene

mRNA expression in normal human tissues for EIF3C Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for EIF3C Gene

SOURCE GeneReport for Unigene cluster for EIF3C Gene Hs.567374

genes like me logo Genes that share expressions with EIF3C: view

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for EIF3C Gene

Orthologs for EIF3C Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for EIF3C Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia -- 36
  • 99 (a)
OneToMany
cow
(Bos Taurus)
Mammalia EIF3C 36
  • 98 (a)
OneToMany
EIF3CL 35
  • 91.81 (n)
  • 97.15 (a)
dog
(Canis familiaris)
Mammalia -- 36
  • 99 (a)
OneToMany
EIF3C 35
  • 91.75 (n)
  • 98.58 (a)
mouse
(Mus musculus)
Mammalia Eif3c 35
  • 89.24 (n)
  • 96.93 (a)
Eif3c 16
Eif3c 36
  • 97 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 93 (a)
ManyToMany
-- 36
  • 96 (a)
ManyToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 91 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Eif3c 35
  • 89.1 (n)
  • 96.38 (a)
chicken
(Gallus gallus)
Aves -- 36
  • 87 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 87 (a)
OneToMany
African clawed frog
(Xenopus laevis)
Amphibia Xl.7935 35
tropical clawed frog
(Silurana tropicalis)
Amphibia eif3c 35
  • 74.71 (n)
  • 80.73 (a)
MGC75608 35
zebrafish
(Danio rerio)
Actinopterygii Dr.28312 35
eif3c 35
  • 73.28 (n)
  • 77.72 (a)
eif3c 36
  • 74 (a)
OneToMany
African malaria mosquito
(Anopheles gambiae)
Insecta EIF3C_ANOGA 35
  • 57.38 (n)
  • 54.57 (a)
fruit fly
(Drosophila melanogaster)
Insecta eIF3-S8 35
  • 60.38 (n)
  • 53.55 (a)
eIF3-S8 36
  • 52 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea eif-3.C 35
  • 52.56 (n)
  • 47.52 (a)
eif-3.C 36
  • 42 (a)
OneToMany
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AGL344C 35
  • 46.21 (n)
  • 33.91 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes NIP1 35
  • 43.45 (n)
  • 33.39 (a)
NIP1 36
  • 25 (a)
OneToMany
NIP1 38
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0F03014g 35
  • 44.53 (n)
  • 34.04 (a)
thale cress
(Arabidopsis thaliana)
eudicotyledons EIF3C 35
  • 52.75 (n)
  • 43.73 (a)
rice
(Oryza sativa)
Liliopsida Os07g0124500 35
  • 51.08 (n)
  • 43.04 (a)
bread mold
(Neurospora crassa)
Ascomycetes NCU07831 35
  • 53.55 (n)
  • 41.99 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes tif33 35
  • 49.02 (n)
  • 41.91 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.3491 35
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 55 (a)
OneToMany
Species with no ortholog for EIF3C:
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for EIF3C Gene

ENSEMBL:
Gene Tree for EIF3C (if available)
TreeFam:
Gene Tree for EIF3C (if available)

Paralogs for EIF3C Gene

genes like me logo Genes that share paralogs with EIF3C: view

No data available for Paralogs for EIF3C Gene

Variants for EIF3C Gene

Sequence variations from dbSNP and Humsavar for EIF3C Gene

SNP ID Clin Chr 16 pos Sequence Context AA Info Type MAF
rs376654 -- 28,727,662(-) ACAAA(C/T)AGGAG intron-variant
rs377345 -- 28,700,623(-) CTGTG(C/T)GGGGC intron-variant
rs381980 -- 28,727,818(-) CACTA(A/G)CAGGA intron-variant
rs413468 -- 28,712,966(+) GGCTG(C/G)AGTGC intron-variant
rs419497 -- 28,701,190(-) gggtg(A/C)ggtgg intron-variant

Structural Variations from Database of Genomic Variants (DGV) for EIF3C Gene

Variant ID Type Subtype PubMed ID
dgv842e1 CNV Complex 17122850
dgv843e1 CNV Complex 17122850
nsv511572 CNV Loss 21212237
nsv833180 CNV Loss 17160897
nsv9414 CNV Gain+Loss 18304495
esv23667 CNV Gain+Loss 19812545
nsv905688 CNV Gain 21882294
nsv821114 CNV Deletion 20802225
nsv905697 CNV Gain 21882294
nsv905698 CNV Gain 21882294
dgv13n14 CNV Gain 18776910
nsv1776 CNV Loss 18451855
esv25666 CNV Gain+Loss 19812545
dgv844e1 CNV Complex 17122850
nsv510683 CNV Loss 20534489
nsv905699 CNV Loss 21882294
nsv9419 CNV Gain+Loss 18304495
nsv820432 CNV Deletion 20802225
esv999954 CNV Loss 20482838
nsv905700 CNV Loss 21882294

Relevant External Links for EIF3C Gene

HapMap Linkage Disequilibrium report
EIF3C
Human Gene Mutation Database (HGMD)
EIF3C

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for EIF3C Gene

Disorders for EIF3C Gene

Relevant External Links for EIF3C

Genetic Association Database (GAD)
EIF3C
genes like me logo Genes that share disorders with EIF3C: view

No data available for UniProtKB/Swiss-Prot for EIF3C Gene

Publications for EIF3C Gene

  1. Conservation and diversity of eukaryotic translation initiation factor eIF3. (PMID: 8995409) Asano K. … Hershey J.W.B. (J. Biol. Chem. 1997) 2 3 4
  2. Structural characterization of the human eukaryotic initiation factor 3 protein complex by mass spectrometry. (PMID: 17322308) Damoc E. … Leary J.A. (Mol. Cell. Proteomics 2007) 3 4
  3. Reconstitution reveals the functional core of mammalian eIF3. (PMID: 17581632) Masutani M. … Imataka H. (EMBO J. 2007) 3 4
  4. Mass spectrometry reveals modularity and a complete subunit interaction map of the eukaryotic translation factor eIF3. (PMID: 18599441) Zhou M. … Robinson C.V. (Proc. Natl. Acad. Sci. U.S.A. 2008) 3 4
  5. Genome duplications and other features in 12 Mb of DNA sequence from human chromosome 16p and 16q. (PMID: 10493829) Loftus B.J. … Adams M.D. (Genomics 1999) 3 4

Products for EIF3C Gene

Sources for EIF3C Gene

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