Free for academic non-profit institutions. Other users need a Commercial license

Aliases for EIF3C Gene

Aliases for EIF3C Gene

  • Eukaryotic Translation Initiation Factor 3 Subunit C 2 3 5
  • Eukaryotic Translation Initiation Factor 3, Subunit 8, 110kDa 2 3
  • Eukaryotic Translation Initiation Factor 3, Subunit C 2 3
  • Eukaryotic Translation Initiation Factor 3 Subunit 8 3 4
  • EIF3 P110 3 4
  • EIF3S8 3 4
  • Eukaryotic Translation Initiation Factor 3, Subunit 8 (110kD) 3
  • Cell Migration-Inducing Protein 17 3
  • EIF3-P110 3
  • EIF3CL 3
  • EIF3c 4

External Ids for EIF3C Gene

Previous HGNC Symbols for EIF3C Gene

  • EIF3S8

Previous GeneCards Identifiers for EIF3C Gene

  • GC16P028631
  • GC16P028723
  • GC16M026450

Summaries for EIF3C Gene

GeneCards Summary for EIF3C Gene

EIF3C (Eukaryotic Translation Initiation Factor 3 Subunit C) is a Protein Coding gene. Among its related pathways are Gene Expression and Transport to the Golgi and subsequent modification. GO annotations related to this gene include poly(A) RNA binding and translation initiation factor activity. An important paralog of this gene is EIF3CL.

UniProtKB/Swiss-Prot for EIF3C Gene

  • Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S preinitiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation.

Gene Wiki entry for EIF3C Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for EIF3C Gene

Genomics for EIF3C Gene

Regulatory Elements for EIF3C Gene

Promoters for EIF3C Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around EIF3C on UCSC Golden Path with GeneCards custom track

Genomic Location for EIF3C Gene

Chromosome:
16
Start:
28,688,558 bp from pter
End:
28,735,730 bp from pter
Size:
47,173 bases
Orientation:
Plus strand

Genomic View for EIF3C Gene

Genes around EIF3C on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
EIF3C Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for EIF3C Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for EIF3C Gene

Proteins for EIF3C Gene

  • Protein details for EIF3C Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q99613-EIF3C_HUMAN
    Recommended name:
    Eukaryotic translation initiation factor 3 subunit C
    Protein Accession:
    Q99613
    Secondary Accessions:
    • A8K7Z0
    • B2RXG3
    • B4E1D5
    • H3BRV0
    • O00215
    • Q9BW98

    Protein attributes for EIF3C Gene

    Size:
    913 amino acids
    Molecular mass:
    105344 Da
    Quaternary structure:
    • Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is composed of 13 subunits: EIF3A, EIF3B, EIF3C, EIF3D, EIF3E, EIF3F, EIF3G, EIF3H, EIF3I, EIF3J, EIF3K, EIF3L and EIF3M. The eIF-3 complex appears to include 3 stable modules: module A is composed of EIF3A, EIF3B, EIF3G and EIF3I; module B is composed of EIF3F, EIF3H, and EIF3M; and module C is composed of EIF3C, EIF3D, EIF3E, EIF3K and EIF3L. EIF3C of module C binds EIF3B of module A and EIF3H of module B, thereby linking the three modules. EIF3J is a labile subunit that binds to the eIF-3 complex via EIF3B. The eIF-3 complex interacts with RPS6KB1 under conditions of nutrient depletion. Mitogenic stimulation leads to binding and activation of a complex composed of MTOR and RPTOR, leading to phosphorylation and release of RPS6KB1 and binding of EIF4B to eIF-3. Identified in a HCV IRES-mediated translation complex, at least composed of EIF3C, IGF2BP1, RPS3 and HCV RNA-replicon. Interacts with ALKBH4, IFIT1 and IFIT2.

    Three dimensional structures from OCA and Proteopedia for EIF3C Gene

    Alternative splice isoforms for EIF3C Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for EIF3C Gene

Proteomics data for EIF3C Gene at MOPED

Post-translational modifications for EIF3C Gene

  • Phosphorylated. Phosphorylation is enhanced upon serum stimulation.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for EIF3C (EIF3C)

No data available for DME Specific Peptides for EIF3C Gene

Domains & Families for EIF3C Gene

Gene Families for EIF3C Gene

Graphical View of Domain Structure for InterPro Entry

Q99613

UniProtKB/Swiss-Prot:

EIF3C_HUMAN :
  • Contains 1 PCI domain.
  • Belongs to the eIF-3 subunit C family.
Domain:
  • Contains 1 PCI domain.
Family:
  • Belongs to the eIF-3 subunit C family.
genes like me logo Genes that share domains with EIF3C: view

Function for EIF3C Gene

Molecular function for EIF3C Gene

UniProtKB/Swiss-Prot Function:
Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S preinitiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation.

Gene Ontology (GO) - Molecular Function for EIF3C Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003743 contributes_to translation initiation factor activity IEA,IDA 17581632
GO:0005515 protein binding IEA,IPI 18628297
genes like me logo Genes that share ontologies with EIF3C: view
genes like me logo Genes that share phenotypes with EIF3C: view

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for EIF3C Gene

Localization for EIF3C Gene

Subcellular locations from UniProtKB/Swiss-Prot for EIF3C Gene

Cytoplasm.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for EIF3C Gene COMPARTMENTS Subcellular localization image for EIF3C gene
Compartment Confidence
cytosol 5
nucleus 2

Gene Ontology (GO) - Cellular Components for EIF3C Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0033290 eukaryotic 48S preinitiation complex IEA --
genes like me logo Genes that share ontologies with EIF3C: view

Pathways & Interactions for EIF3C Gene

genes like me logo Genes that share pathways with EIF3C: view

Pathways by source for EIF3C Gene

1 KEGG pathway for EIF3C Gene
2 Qiagen pathways for EIF3C Gene

Gene Ontology (GO) - Biological Process for EIF3C Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006413 translational initiation IEA,TAS --
GO:0006446 regulation of translational initiation IEA --
genes like me logo Genes that share ontologies with EIF3C: view

No data available for SIGNOR curated interactions for EIF3C Gene

Drugs & Compounds for EIF3C Gene

No Compound Related Data Available

Transcripts for EIF3C Gene

Unigene Clusters for EIF3C Gene

Eukaryotic translation initiation factor 3, subunit C:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for EIF3C Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3 ^ 4 ^ 5a · 5b · 5c ^ 6a · 6b ^ 7 ^ 8 ^ 9a · 9b ^ 10 ^ 11 ^ 12a · 12b · 12c · 12d ^ 13 ^ 14a · 14b · 14c ^
SP1: - - - - -
SP2: - - - - - - -
SP3: - - -
SP4:
SP5: - - - - - - - - - - - - - - - - - - - -
SP6:
SP7: - - - - - - - -
SP8: - -
SP9:
SP10:
SP11:
SP12: - -
SP13: -
SP14:

ExUns: 15a · 15b ^ 16 ^ 17a · 17b ^ 18a · 18b · 18c ^ 19a · 19b · 19c ^ 20 ^ 21a · 21b ^ 22 ^ 23a · 23b ^ 24a · 24b
SP1:
SP2:
SP3:
SP4:
SP5: - - - - - -
SP6:
SP7:
SP8:
SP9: - - -
SP10: - - - - - -
SP11:
SP12:
SP13:
SP14:

Relevant External Links for EIF3C Gene

GeneLoc Exon Structure for
EIF3C
ECgene alternative splicing isoforms for
EIF3C

Expression for EIF3C Gene

mRNA expression in normal human tissues for EIF3C Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for EIF3C Gene

This gene is overexpressed in Lymph node (7.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for EIF3C Gene



SOURCE GeneReport for Unigene cluster for EIF3C Gene Hs.567374

genes like me logo Genes that share expression patterns with EIF3C: view

Protein tissue co-expression partners for EIF3C Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for EIF3C Gene

Orthologs for EIF3C Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for EIF3C Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia -- 36
  • 99 (a)
OneToMany
cow
(Bos Taurus)
Mammalia EIF3C 36
  • 98 (a)
OneToMany
EIF3CL 35
  • 91.81 (n)
  • 97.15 (a)
dog
(Canis familiaris)
Mammalia EIF3C 35
  • 91.75 (n)
  • 98.58 (a)
-- 36
  • 99 (a)
OneToMany
mouse
(Mus musculus)
Mammalia Eif3c 36
  • 97 (a)
OneToMany
Eif3c 16
Eif3c 35
  • 89.24 (n)
  • 96.93 (a)
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 93 (a)
ManyToMany
-- 36
  • 96 (a)
ManyToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 91 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Eif3c 35
  • 89.1 (n)
  • 96.38 (a)
chicken
(Gallus gallus)
Aves -- 36
  • 87 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 87 (a)
OneToMany
African clawed frog
(Xenopus laevis)
Amphibia Xl.7935 35
tropical clawed frog
(Silurana tropicalis)
Amphibia eif3c 35
  • 74.71 (n)
  • 80.73 (a)
MGC75608 35
zebrafish
(Danio rerio)
Actinopterygii Dr.28312 35
eif3c 35
  • 73.28 (n)
  • 77.72 (a)
eif3c 36
  • 74 (a)
OneToMany
African malaria mosquito
(Anopheles gambiae)
Insecta EIF3C_ANOGA 35
  • 57.38 (n)
  • 54.57 (a)
fruit fly
(Drosophila melanogaster)
Insecta eIF3-S8 36
  • 52 (a)
OneToMany
eIF3-S8 35
  • 60.38 (n)
  • 53.55 (a)
worm
(Caenorhabditis elegans)
Secernentea eif-3.C 36
  • 42 (a)
OneToMany
eif-3.C 35
  • 52.56 (n)
  • 47.52 (a)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AGL344C 35
  • 46.21 (n)
  • 33.91 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes NIP1 35
  • 43.45 (n)
  • 33.39 (a)
NIP1 36
  • 25 (a)
OneToMany
NIP1 38
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0F03014g 35
  • 44.53 (n)
  • 34.04 (a)
thale cress
(Arabidopsis thaliana)
eudicotyledons EIF3C 35
  • 52.75 (n)
  • 43.73 (a)
rice
(Oryza sativa)
Liliopsida Os07g0124500 35
  • 51.08 (n)
  • 43.04 (a)
bread mold
(Neurospora crassa)
Ascomycetes NCU07831 35
  • 53.55 (n)
  • 41.99 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes tif33 35
  • 49.02 (n)
  • 41.91 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.3491 35
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 55 (a)
OneToMany
Species with no ortholog for EIF3C:
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for EIF3C Gene

ENSEMBL:
Gene Tree for EIF3C (if available)
TreeFam:
Gene Tree for EIF3C (if available)

Paralogs for EIF3C Gene

Paralogs for EIF3C Gene

genes like me logo Genes that share paralogs with EIF3C: view

Variants for EIF3C Gene

Structural Variations from Database of Genomic Variants (DGV) for EIF3C Gene

Variant ID Type Subtype PubMed ID
dgv842e1 CNV Complex 17122850
dgv843e1 CNV Complex 17122850
nsv511572 CNV Loss 21212237
nsv833180 CNV Loss 17160897
nsv9414 CNV Gain+Loss 18304495
esv23667 CNV Gain+Loss 19812545
nsv905688 CNV Gain 21882294
nsv821114 CNV Deletion 20802225
nsv905697 CNV Gain 21882294
nsv905698 CNV Gain 21882294
dgv13n14 CNV Gain 18776910
nsv1776 CNV Loss 18451855
esv25666 CNV Gain+Loss 19812545
dgv844e1 CNV Complex 17122850
nsv510683 CNV Loss 20534489
nsv905699 CNV Loss 21882294
nsv9419 CNV Gain+Loss 18304495
nsv820432 CNV Deletion 20802225
esv999954 CNV Loss 20482838
nsv905700 CNV Loss 21882294

Variation tolerance for EIF3C Gene

Gene Damage Index Score: 0.30; 6.75% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for EIF3C Gene

HapMap Linkage Disequilibrium report
EIF3C
Human Gene Mutation Database (HGMD)
EIF3C

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations from dbSNP and Humsavar for EIF3C Gene

Disorders for EIF3C Gene

Relevant External Links for EIF3C

Genetic Association Database (GAD)
EIF3C
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
EIF3C

No disorders were found for EIF3C Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for EIF3C Gene

Publications for EIF3C Gene

  1. Conservation and diversity of eukaryotic translation initiation factor eIF3. (PMID: 8995409) Asano K. … Hershey J.W.B. (J. Biol. Chem. 1997) 2 3 4 67
  2. Integrative analysis of kinase networks in TRAIL-induced apoptosis provides a source of potential targets for combination therapy. (PMID: 25852190) So J. … Colwill K. (Sci Signal 2015) 3
  3. Temporal proteomics of NGF-TrkA signaling identifies an inhibitory role for the E3 ligase Cbl-b in neuroblastoma cell differentiation. (PMID: 25921289) Emdal K.B. … Olsen J.V. (Sci Signal 2015) 3
  4. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  5. Panorama of ancient metazoan macromolecular complexes. (PMID: 26344197) Wan C. … Emili A. (Nature 2015) 3

Products for EIF3C Gene

Sources for EIF3C Gene

Back to Top

Content