EIF3C Gene
protein-coding GIFtS: 56
GCID: GC16P028700
|
|
eukaryotic translation initiation factor 3, subunit C(Previous names: eukaryotic translation initiation factor 3, subunit 8,...)
(Previous symbol: EIF3S8)
| |
Aliases
for EIF3C gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Eukaryotic Translation Initiation Factor 3, Subunit C1 2 | | EIF3 P1102 3 | | EIF3S81 2 3 5 | | EIF3CL2 | | EIF3-P1101 | | Cell Migration-Inducing Protein 172 | | Eukaryotic Translation Initiation Factor 3, Subunit 8, 110kDa1 2 | | Eukaryotic Translation Initiation Factor 3 Subunit C2 | | EIF3c1 | | Eukaryotic Translation Initiation Factor 3, Subunit 8 (110kD)2 | | Eukaryotic Translation Initiation Factor 3 Subunit 82 3 | | |
Export aliases for EIF3C gene to outside databasesPrevious GC identifers: GC16P028631 GC16P028723 GC16M026450 |
Summaries
for EIF3C gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
UniProtKB/Swiss-Prot: EIF3C_HUMAN, Q99613Function: Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for severalsteps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and facilitates therecruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S preinitiation complex (43S PIC). TheeIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequentlyprevents premature joining of the 40S and 60S ribosomal subunits prior to initiation
Gene Wiki entry for EIF3C
|
Genomic Views
for EIF3C gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000016.9 NC_018927.1 NT_010393.16
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the EIF3C gene promoter:
NF-1/L NF-1 GATA-3 HSF1 (long) GATA-1 GATA-2 PPAR-alpha HSF2 c-Myb HSF1short
Other transcription factors
Search SABiosciences Chromatin IP Primers for EIF3C
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat EIF3C |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 16p11.2 Ensembl cytogenetic band: 16p11.2 HGNC cytogenetic band: 16p11.2EIF3C Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 16 GeneLoc Exon Structure GeneLoc location for GC16P028700: view genomic region
(about GC identifiers)
Start:
|
28,699,879 bp from pter |
End:
|
28,747,051 bp from pter |
Size:
|
47,173 bases |
Orientation:
|
plus strand |
|
Proteins
for EIF3C gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: EIF3C_HUMAN, Q99613 (See
protein sequence)Recommended Name: Eukaryotic translation initiation factor 3 subunit C Size: 913 amino acids; 105344 Da
Subunit: Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is composed of 13 subunits:EIF3A, EIF3B, EIF3C, EIF3D, EIF3E, EIF3F, EIF3G, EIF3H, EIF3I, EIF3J, EIF3K, EIF3L and EIF3M. The eIF-3 complexappears to include 3 stable modules: module A is composed of EIF3A, EIF3B, EIF3G and EIF3I; module B is composed ofEIF3F, EIF3H, and EIF3M; and module C is composed of EIF3C, EIF3D, EIF3E, EIF3K and EIF3L. EIF3C of module C bindsEIF3B of module A and EIF3H of module B, thereby linking the three modules. EIF3J is a labile subunit that binds tothe eIF-3 complex via EIF3B. The eIF-3 complex interacts with RPS6KB1 under conditions of nutrient depletion.Mitogenic stimulation leads to binding and activation of a complex composed of MTOR and RPTOR, leading tophosphorylation and release of RPS6KB1 and binding of EIF4B to eIF-3. Identified in a HCV IRES-mediated translationcomplex, at least composed of EIF3C, IGF2BP1, RPS3 and HCV RNA-replicon. Interacts with IFIT1 and IFIT2
Subcellular location: Cytoplasm (By similarity)
Mass spectrometry: Mass=106143.8; Method=Unknown; Range=1-913; Source=PubMed:17322308;
Mass spectrometry: Mass=106855; Mass_error=40; Method=MALDI; Range=1-913; Source=PubMed:18599441;
Secondary accessions: A8K7Z0 B2RXG3 O00215 Q9BW98Explore the universe of human proteins at neXtProt for EIF3C: NX_Q99613
Post-translational modifications:
Phosphorylated. Phosphorylation is enhanced upon serum stimulation1
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q99613
EIF3C Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins (4 alternative transcripts):
NP_001032897.1 NP_001186071.1 NP_001254503.1 NP_003743.1
ENSEMBL proteins: ENSP00000457963 ENSP00000332604 ENSP00000455278 ENSP00000456416 ENSP00000457418 ENSP00000457389 ENSP00000455277 ENSP00000378953 Reactome Protein details: Q99613
Human Recombinant Protein Products:
Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view): About this table
EIF3C for ontologies About GeneDecksing
EIF3C Antibody Products:
Assay Products for EIF3C: |
Protein
Domains /
Families
for EIF3C gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
EIF3C for domains About GeneDecksing
3 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q99613ProtoNet protein and cluster: Q99613 2 Blocks protein families: IPB000717 Domain in components of the proteasome IPB008905 Eukaryotic translation initiation factor 3 subunit 8
UniProtKB/Swiss-Prot: EIF3C_HUMAN, Q99613Similarity: Belongs to the eIF-3 subunit C familySimilarity: Contains 1 PCI domain |
Function
for EIF3C gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: EIF3C_HUMAN, Q99613Function: Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for severalsteps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and facilitates therecruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S preinitiation complex (43S PIC). TheeIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequentlyprevents premature joining of the 40S and 60S ribosomal subunits prior to initiation
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for EIF3C (see all 4)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for EIF3C (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector (see all 3): EIF3C (NM_003752) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for EIF3C | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat EIF3C |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for EIF3C |
Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0003743 | contributes to translation initiation factor activity |
IDA | 17581632 | | GO:0005515 | protein binding |
IPI | -- |
EIF3C for ontologies About GeneDecksing
9 GenomeRNAi human phenotypes for EIF3C:
Animal Models:
7 MGI mutant phenotypes (inferred from 3 alleles ) (MGI details for Eif3c):
EIF3C for phenotypes About GeneDecksing
|
Pathways & Interactions
for EIF3C gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | Translation Factors | | | 2 | RNA transport | | | 3 | Translational Control | |
Pathway sources
See GeneCards unified pathways
Show all pathways
1 
Cell Signaling Technology (CST) Pathway for EIF3C
1  BioSystems Pathway for EIF3C
5/13 
Reactome Pathways for EIF3C (see all 13)
1 
Kegg Pathway (Kegg details for EIF3C):
EIF3C for pathways About GeneDecksing
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for EIF3C
STRING Interaction
Network Preview (showing 5 interactants - click image to see 25)
5/112 Interacting proteins for EIF3C (Q996131, 2, 3 ENSP000003326044) via UniProtKB, MINT, STRING, and/or I2D (see all 112)About this table
Gene Ontology (GO): 4 biological process terms (GO ID links to tree view): About this table
EIF3C for ontologies About GeneDecksing
|
Drugs & Compounds
for EIF3C gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for EIF3C
Search CenterWatch for drugs/clinical trials and news about EIF3C
|
Transcripts
for EIF3C gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for EIF3C gene (4 alternative transcripts): NM_001037808.1 NM_001199142.1 NM_001267574.1 NM_003752.3 Unigene Cluster for EIF3C: Eukaryotic translation initiation factor 3, subunit C Hs.567374 [show with all ESTs]Unigene Representative Sequence: NM_00119914214 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000566501(uc010byi.3) ENST00000331666(uc002dqs.4 uc010vcy.2)
ENST00000569690 ENST00000564243 ENST00000566866 ENST00000563139 ENST00000568426
ENST00000565099 ENST00000565932(uc002dqv.4) ENST00000564839 ENST00000566519
ENST00000569005 ENST00000566086 ENST00000395587(uc002dqt.4 uc010byj.3 uc002dqu.4)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for EIF3C (see all 4)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for EIF3C (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector (see all 3): EIF3C (NM_003752) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for EIF3C | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat EIF3C |
Additional cDNA sequence: AK000739.1 AK055366.1 AK130531.1 AK292155.1 AK293264.1 AK299421.1 AK301183.1 AK301233.1 AK303790.1 AK304500.1 AY762099.1 BC000533.2 BC001571.1 BC071705.1 BC107692.1 BC157842.1 BC157849.1 BT007335.1 24/92 DOTS entries (see all 92): DT.100657002 DT.92471241 DT.91907929 DT.120695317 DT.100686649 DT.120695631 DT.95213205 DT.120695342 DT.120696091 DT.95260779 DT.100686677 DT.100686656 DT.100686652 DT.100686662 DT.120695984 DT.120697057 DT.91921517 DT.95260843 DT.120696153 DT.91801554 DT.120696456 DT.120697280 DT.120695460 DT.120696319 24/1582 AceView cDNA sequences (see all 1582): BF794715 BG764010 CB153665 BQ220813 BQ642594 BU181531 AI261771 BQ686875 BM550299 BQ948930 CA420261 BM795828 BM822021 BQ056382 BQ223149 BU192200 BU157730 AI872359 BG819430 BQ055804 CD367708 BU147417 BM475014 CF125798
GeneLoc Exon Structure
5/14 Alternative Splicing Database (ASD) splice patterns (SP) for EIF3C (see all 14) About this scheme
| ExUns: | 1a | · | 1b | · | 1c | ^ | 2a | · | 2b | ^ | 3 | ^ | 4 | ^ | 5a | · | 5b | · | 5c | ^ | 6a | · | 6b | ^ | 7 | ^ | 8 | ^ | 9a | · | 9b | ^ | 10 | ^ | 11 | ^ | 12a | · | 12b | · | 12c | · | 12d | ^ | 13 | ^ | 14a | · | 14b | · | 14c | ^ |
|---|
|
| SP1: | | | | | | | - | | - | | | | | | | | | | | | | | | | | | | | | | | | - | | - | | - | | | | | | | | | | | | | | | | |
| SP2: | | | | | | | - | | - | | | | | | | | | | - | | - | | | | | | | | | | | | - | | - | | - | | | | | | | | | | | | | | | | |
| SP3: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | - | | - | | - | | | | | | | | | | | | | | | | |
| SP4: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP5: | | | | | | | - | | - | | | | | | | | - | | - | | - | | - | | - | | - | | - | | - | | - | | - | | - | | - | | - | | - | | - | | - | | - | | - | |
| ExUns: | 15a | · | 15b | ^ | 16 | ^ | 17a | · | 17b | ^ | 18a | · | 18b | · | 18c | ^ | 19a | · | 19b | · | 19c | ^ | 20 | ^ | 21a | · | 21b | ^ | 22 | ^ | 23a | · | 23b | ^ | 24a | · | 24b |
|---|
|
| SP1: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP2: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP3: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP4: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP5: | - | | - | | - | | - | | - | | - | | | | | | | | | | | | | | | | | | | | | | | | | | | |
ECgene alternative splicing isoforms for EIF3C
|
Expression
for EIF3C gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| EIF3C expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: CGCCGCGGTG
About this image
See EIF3C Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for EIF3C
SOURCE GeneReport for Unigene cluster: Hs.567374
SABiosciences Custom PCR Arrays for EIF3C
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for EIF3C
Browse OriGene validated miRNA SYBR primer pairs
| | | Search SABiosciences RT2 qPCR
Primer Assays in human, mouse, rat EIF3C | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat EIF3C | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat EIF3C | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for EIF3C |
Orthologs
for EIF3C gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of eukaryotes.
Orthologs for EIF3C gene from 8/34 species (see all 34) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
lizard
(Anolis carolinensis) |
Reptilia |
-- |
-- |
86(a) |
1 → many |
GL343287.1(716804-729526) |
African clawed frog
(Xenopus laevis) |
Amphibia |
Xl.79352 |
Xenopus laevis, clone IMAGE5543333, mRNA |
81.22(n) |
|
BC046704.1 |
zebrafish
(Danio rerio) |
Actinopterygii |
Dr.283122 |
Danio rerio cDNA clone MGC66128 IMAGE2642152, complete more |
78.57(n) |
|
BC057465.1 |
fruit fly
(Drosophila melanogaster) |
Insecta |
eIF3-S81 |
CG4954-PA |
60.38(n)
54.6(a) |
|
37005 NM_137398.1 NP_611242.1 |
worm
(Caenorhabditis elegans) |
Secernentea |
eif-3.C1 |
Protein EIF-3.C |
53.01(n)
46.95(a) |
|
172858 NM_060237.2 NP_492638.1 |
baker's yeast
(Saccharomyces cerevisiae) |
Saccharomycetes |
NIP1(YMR309C)4
NIP11 |
eIF3c subunit of the eukaryotic translation initiation more4
Nip1p1 |
42.68(n)1
31.82(a)1 |
|
13(895426-892988)4
8553571, 4 NP_014040.11, 4 |
thale cress
(Arabidopsis thaliana) |
eudicotyledons |
EIF3C1 |
translation initiation factor eIF-3 subunit 8 |
51.97(n)
43.59(a) |
|
824781 NM_001203173.1 NP_001190102.1 |
rice
(Oryza sativa) |
Liliopsida |
Os07g01245001 |
hypothetical protein |
50.58(n)
42.15(a) |
|
4342306 NM_001065339.1 NP_001058804.1 |
ENSEMBL Gene Tree for EIF3C (if available)
TreeFam Gene Tree for EIF3C (if available) |
Paralogs
for EIF3C gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for EIF3C gene
- EIF3CL1 2
1 SIMAP similar gene for EIF3C using alignment to 6 protein entries: EIF3C_HUMAN (see all proteins):EIF3CL
EIF3C for paralogs About GeneDecksing
|
Genomic Variants
for EIF3C gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 16 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for EIF3C (28699879 - 28747051 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 25 variations for EIF3C
15/25 CNVs (see all 25): 88041 4937 72516 77252 3999 66972 72513 35381 88045 77254 30773 30772 88048 88043 30768 | SABiosciences Cancer Mutation PCR Assays |
|
Disorders
/ Diseases
for EIF3C gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
EIF3C for disorders About GeneDecksing
OMIM gene information: 603916
OMIM disorders: --
5  diseases for EIF3C: About MalaCardsinflammatory bowel disease fanconi's anemia crohn's disease anemia
malaria
Export disorders for EIF3C gene to outside databases
|
Publications
for EIF3C gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for EIF3C gene, integrated from 9 sources (see all 70):
(articles sorted by number of sources associating them with EIF3C) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Conservation and diversity of eukaryotic translation initiation factor eIF3. (PubMed id 8995409)1, 2, 3 Asano K....Hershey J.W. (1997)
- Mass spectrometry reveals modularity and a complete subunit interaction map of the eukaryotic translation factor eIF3. (PubMed id 18599441)1, 2 Zhou M....Robinson C.V. (2008)
- Reconstitution reveals the functional core of mammalian eIF3. (PubMed id 17581632)1, 2 Masutani M.... Imataka H. (2007)
- Structural characterization of the human eukaryotic initiation factor 3 protein complex by mass spectrometry. (PubMed id 17322308)1, 2 Damoc E....Leary J.A. (2007)
- A probability-based approach for high-throughput protein phosphorylation analysis and site localization. (PubMed id 16964243)1, 2 Beausoleil S.A.... Gygi S.P. (2006)
- Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)1, 2 Olsen J.V....Mann M. (2006)
- mTOR and S6K1 mediate assembly of the translation preinitiation complex through dynamic protein interchange and ordered phosphorylation events. (PubMed id 16286006)1, 2 Holz M.K.... Blenis J. (2005)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Characterization of eIF3k: a newly discovered subunit of mammalian translation initiation factor elF3. (PubMed id 14519125)1, 2 Mayeur G.L....Hershey J.W. (2003)
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External Searches for EIF3C gene
(in PubMed,
OMIM, and NCBI Bookshelf)
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Genome Databases showing EIF3C gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
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Other Databases showing EIF3C gene
(According to HUGE)
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Specialized Databases showing EIF3C gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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| Patent Information for EIF3C gene:
Search GeneIP for patents involving EIF3C
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
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Products
for EIF3C gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
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| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for EIF3C | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for EIF3C | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for EIF3C | | | OriGene Protein Over-expression Lysate for EIF3C | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for EIF3C | | OriGene 3'-UTR Clone for EIF3C | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for EIF3C | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for EIF3C | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | OriGene Purified Protein for EIF3C | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for EIF3C | | OriGene Custom Protein Services for EIF3C | | | OriGene Custom Immunoassay Development | | |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat EIF3C | | | Search QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing EIF3C | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat EIF3C | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat EIF3C | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat EIF3C | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat EIF3C |
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| | Antibodies & Assays for EIF3C |
| | | | Search Tocris compounds for EIF3C |
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 | | | EIF3C Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for EIF3C |
|  |  |  | | | | ThermoFisher Antibodies for EIF3C |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat EIF3C |
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