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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

EIF3C Gene

protein-coding   GIFtS: 59
GCID: GC16P028700

Eukaryotic Translation Initiation Factor 3, Subunit C

(Previous names: eukaryotic translation initiation factor 3, subunit 8, 11...)
(Previous symbol: EIF3S8)
Microbiology & Infectious Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Eukaryotic Translation Initiation Factor 3, Subunit C1 2     Cell Migration-Inducing Protein 172
EIF3S81 2 3 5     eIF3-p1102
Eukaryotic Translation Initiation Factor 3, Subunit 8, 110kDa1 2     Eukaryotic Translation Initiation Factor 3 Subunit C2
Eukaryotic Translation Initiation Factor 3 Subunit 82 3     Eukaryotic Translation Initiation Factor 3, Subunit 8 (110kD)2
EIF3 P1102 3     eIF3c3
EIF3CL2     

External Ids:    HGNC: 32791   Entrez Gene: 86632   Ensembl: ENSG000001841107   OMIM: 6039165   UniProtKB: Q996133   

Export aliases for EIF3C gene to outside databases

Previous GC identifers: GC16P028631 GC16P028723 GC16M026450


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for EIF3C Gene: 
EIF3C (eukaryotic translation initiation factor 3, subunit C) is a protein-coding gene. Diseases associated with EIF3C include fanconi's anemia, and colon adenocarcinoma, and among its related super-pathways are Eukaryotic Translation Initiation and Formation of the ternary complex, and subsequently, the 43S complex. GO annotations related to this gene include protein binding and translation initiation factor activity. An important paralog of this gene is EIF3CL.

UniProtKB/Swiss-Prot: EIF3C_HUMAN, Q99613
Function: Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for
several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and
facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S preinitiation
complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG
recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal
complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation

Gene Wiki entry for EIF3C Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000016.9  NT_010393.16  NC_018927.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the EIF3C gene promoter:
         NF-1/L   NF-1   GATA-3   HSF1 (long)   GATA-1   GATA-2   PPAR-alpha   HSF2   c-Myb   HSF1short   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidEIF3C promoter sequence
   Search SABiosciences Chromatin IP Primers for EIF3C

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat EIF3C


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 16p11.2   Ensembl cytogenetic band:  16p11.2   HGNC cytogenetic band: 16p11.2

EIF3C Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
EIF3C gene location

GeneLoc information about chromosome 16         GeneLoc Exon Structure

GeneLoc location for GC16P028700:  view genomic region     (about GC identifiers)

Start:
28,699,879 bp from pter      End:
28,747,051 bp from pter
Size:
47,173 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: EIF3C_HUMAN, Q99613 (See protein sequence)
Recommended Name: Eukaryotic translation initiation factor 3 subunit C  
Size: 913 amino acids; 105344 Da
Subunit: Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is composed of 13
subunits: EIF3A, EIF3B, EIF3C, EIF3D, EIF3E, EIF3F, EIF3G, EIF3H, EIF3I, EIF3J, EIF3K, EIF3L and EIF3M. The eIF-3
complex appears to include 3 stable modules: module A is composed of EIF3A, EIF3B, EIF3G and EIF3I; module B is
composed of EIF3F, EIF3H, and EIF3M; and module C is composed of EIF3C, EIF3D, EIF3E, EIF3K and EIF3L. EIF3C of
module C binds EIF3B of module A and EIF3H of module B, thereby linking the three modules. EIF3J is a labile
subunit that binds to the eIF-3 complex via EIF3B. The eIF-3 complex interacts with RPS6KB1 under conditions of
nutrient depletion. Mitogenic stimulation leads to binding and activation of a complex composed of MTOR and
RPTOR, leading to phosphorylation and release of RPS6KB1 and binding of EIF4B to eIF-3. Identified in a HCV
IRES-mediated translation complex, at least composed of EIF3C, IGF2BP1, RPS3 and HCV RNA-replicon. Interacts with
IFIT1 and IFIT2
Subcellular location: Cytoplasm (By similarity)
Mass spectrometry: Mass=106143.8; Method=Unknown; Range=1-913; Source=PubMed:17322308;
Mass spectrometry: Mass=106855; Mass_error=40; Method=MALDI; Range=1-913; Source=PubMed:18599441;
Secondary accessions: A8K7Z0 B2RXG3 O00215 Q9BW98

Explore the universe of human proteins at neXtProt for EIF3C: NX_Q99613

Explore proteomics data for EIF3C at MOPED 

Post-translational modifications:

  • UniProtKB: Phosphorylated. Phosphorylation is enhanced upon serum stimulation
  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q99613

  • EIF3C Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    EIF3C Protein Expression
    REFSEQ proteins (4 alternative transcripts): 
    NP_001032897.1  NP_001186071.1  NP_001254503.1  NP_003743.1  

    ENSEMBL proteins: 
     ENSP00000457963   ENSP00000332604   ENSP00000455278   ENSP00000456416   ENSP00000457418  
     ENSP00000457389   ENSP00000455277   ENSP00000378953  
    Reactome Protein details: Q99613
    Human Recombinant Protein Products for EIF3C: 
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    Cloud-Clone Corp. Proteins for EIF3C 

    Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005829cytosol TAS--
    GO:0005852eukaryotic translation initiation factor 3 complex IDA17322308
    GO:0016282eukaryotic 43S preinitiation complex IEA--
    GO:0033290eukaryotic 48S preinitiation complex IEA--

    EIF3C for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    4 InterPro protein domains:
     IPR000717 PCI_dom
     IPR011991 WHTH_DNA-bd_dom
     IPR027516 EIF3C
     IPR008905 EIF3C_N_dom

    Graphical View of Domain Structure for InterPro Entry Q99613

    ProtoNet protein and cluster: Q99613

    2 Blocks protein domains:
    IPB000717 Domain in components of the proteasome
    IPB008905 Eukaryotic translation initiation factor 3 subunit 8


    UniProtKB/Swiss-Prot: EIF3C_HUMAN, Q99613
    Similarity: Belongs to the eIF-3 subunit C family
    Similarity: Contains 1 PCI domain


    EIF3C for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: EIF3C_HUMAN, Q99613
    Function: Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for
    several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and
    facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S preinitiation
    complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG
    recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal
    complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation

         Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003743contributes to translation initiation factor activity IDA17581632
    GO:0005488binding ----
    GO:0005515protein binding IPI18628297
    GO:0031369translation initiation factor binding IEA--
         
    EIF3C for ontologies           About GeneDecksing


    Phenotypes:
         9 GenomeRNAi human phenotypes for EIF3C:
     Decreased G3BP1 protein expres  Decreased influenza A H1N1 (A/  Decreased influenza A/WSN/33 r  Decreased nuclei size in G2M 
     Decreased viability of wild-ty  Increased S DNA content  Increased cell death in HCT116  S arrest 
     Synthetic lethal with Ras 

         7 MGI mutant phenotypes (inferred from 3 alleles(MGI details for Eif3c):
     craniofacial  growth/size  hearing/vestibular/ear  integument  limbs/digits/tail 
     mortality/aging  pigmentation 

    EIF3C for phenotypes           About GeneDecksing

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for EIF3C 
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for EIF3C 
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    SwitchGear 3'UTR luciferase reporter plasmidEIF3C 3' UTR sequence
    Inhib. RNA
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for EIF3C About   (see all 7)                                                                                              See pathways by source

    SuperPathContained pathways About
    1Viral mRNA Translation
    GTP hydrolysis and joining of the 60S ribosomal subunit0.94
    L13a-mediated translational silencing of Ceruloplasmin expression0.93
    Eukaryotic Translation Initiation0.94
    Formation of a pool of free 40S subunits0.90
    Cap-dependent Translation Initiation0.94
    Translation0.78
    3' -UTR-mediated translational regulation0.93
    2Translation initiation complex formation
    Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S0.95
    Formation of the ternary complex, and subsequently, the 43S complex0.87
    Ribosomal scanning and start codon recognition0.95
    Translation initiation complex formation0.87
    3Generic Transcription Pathway
    Gene Expression0.47
    4Asparagine N-linked glycosylation
    Metabolism of proteins0.35
    5Translation Factors
    Translation Factors

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 Cell Signaling Technology (CST) Pathway for EIF3C
        Translational Control

    1 BioSystems Pathway for EIF3C
        Translation Factors

    5/13        Reactome Pathways for EIF3C (see all 13)
        Formation of the ternary complex, and subsequently, the 43S complex
    Translation
    GTP hydrolysis and joining of the 60S ribosomal subunit
    Eukaryotic Translation Initiation
    Ribosomal scanning and start codon recognition


    1         Kegg Pathway  (Kegg details for EIF3C):
        RNA transport


    EIF3C for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for EIF3C

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/112 Interacting proteins for EIF3C (Q996131, 2, 3 ENSP000003326044) via UniProtKB, MINT, STRING, and/or I2D (see all 112)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    EIF3BP558842, 3, ENSP000003541254MINT-6948891 I2D: score=6 STRING: ENSP00000354125
    AAGABQ6PD742, 3, ENSP000002618804MINT-64673 I2D: score=5 STRING: ENSP00000261880
    EIF3FO003032, 3, ENSP000003100404MINT-6948891 I2D: score=1 STRING: ENSP00000310040
    SMAD9O151982, 3MINT-62117 I2D: score=3 
    SNIP1Q8TAD82, 3MINT-62165 I2D: score=3 
    About this table

    Gene Ontology (GO): 5/6 biological process terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001731formation of translation preinitiation complex IEA--
    GO:0006412translation TAS--
    GO:0006413translational initiation TAS--
    GO:0006446regulation of translational initiation IEA--
    GO:0010467gene expression TAS--

    EIF3C for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for EIF3C

    Search CenterWatch for drugs/clinical trials and news about EIF3C

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for EIF3C gene (4 alternative transcripts): 
    NM_001037808.1  NM_001199142.1  NM_001267574.1  NM_003752.3  

    Unigene Cluster for EIF3C:

    Eukaryotic translation initiation factor 3, subunit C
    Hs.567374  [show with all ESTs]
    Unigene Representative Sequence: NM_001199142
    14 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000566501(uc010byi.3) ENST00000331666(uc002dqs.4 uc010vcy.2)
    ENST00000569690 ENST00000564243 ENST00000566866 ENST00000563139 ENST00000568426
    ENST00000565099 ENST00000565932(uc002dqv.4) ENST00000564839 ENST00000566519
    ENST00000569005 ENST00000566086 ENST00000395587(uc002dqt.4 uc010byj.3 uc002dqu.4)

    Congresses - knowledge worth sharing:  
    European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

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    Additional mRNA sequence: 

    AK000739.1 AK055366.1 AK130531.1 AK292155.1 AK293264.1 AK299421.1 AK301183.1 AK301233.1 
    AK303790.1 AK304500.1 AY762099.1 BC000533.2 BC001571.1 BC071705.1 BC107692.1 BC157842.1 
    BC157849.1 BT007335.1 

    24/92 DOTS entries (see all 92):

    DT.100657002  DT.92471241  DT.91907929  DT.120695317  DT.100686649  DT.120695631  DT.95213205  DT.120695342 
    DT.120696091  DT.95260779  DT.100686677  DT.100686656  DT.100686652  DT.100686662  DT.120695984  DT.120697057 
    DT.91921517  DT.95260843  DT.120696153  DT.91801554  DT.120696456  DT.120697280  DT.120695460  DT.120696319 

    24/1582 AceView cDNA sequences (see all 1582):

    BQ651829 BU860213 BQ279178 BQ942570 BU855736 BE791395 BE893250 BU838263 
    BM998987 BU161343 BE295286 BQ691093 BG290673 BU194251 BI335348 CB140572 
    AW247507 BU161261 BM557641 BP381706 BQ216955 BU176655 T31686 BQ645572 

    GeneLoc Exon Structure

    5/14 Alternative Splicing Database (ASD) splice patterns (SP) for EIF3C (see all 14)    About this scheme

    ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3 ^ 4 ^ 5a · 5b · 5c ^ 6a · 6b ^ 7 ^ 8 ^ 9a · 9b ^ 10 ^ 11 ^ 12a · 12b · 12c · 12d ^ 13 ^ 14a · 14b · 14c ^
    SP1:                    -     -                                                                       -     -     -                                             
    SP2:                    -     -                             -     -                                   -     -     -                                             
    SP3:                                                                                                  -     -     -                                             
    SP4:                                                                                                                                                            
    SP5:                    -     -                       -     -     -     -     -     -     -     -     -     -     -     -     -     -     -     -     -     -   

    ExUns: 15a · 15b ^ 16 ^ 17a · 17b ^ 18a · 18b · 18c ^ 19a · 19b · 19c ^ 20 ^ 21a · 21b ^ 22 ^ 23a · 23b ^ 24a · 24b
    SP1:                                                                                                                  
    SP2:                                                                                                                  
    SP3:                                                                                                                  
    SP4:                                                                                                                  
    SP5:  -     -     -     -     -     -                                                                                 


    ECgene alternative splicing isoforms for EIF3C

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    EIF3C expression in normal human tissues (normalized intensities)      EIF3C embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CGCCGCGGTG
    EIF3C Expression
    About this image


    EIF3C expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/19 selected tissues (see all 19) fully expand
     
     Brain (Nervous System)    fully expand to see all 4 entries
             Cerebral Cortex
     
     Colon (Gastrointestinal Tract)    fully expand to see all 2 entries
             rectum ; glandular cells   
     
     Intestine (Gastrointestinal Tract)    fully expand to see all 2 entries
             small intestine ; glandular cells   
     
     Tonsil (Hematopoietic System)    fully expand to see all 2 entries
             tonsil ; squamous epithelial cells   
     
     Placenta (Extraembryonic Tissues)    fully expand to see all 2 entries
             placenta ; decidual cells   

    See EIF3C Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for EIF3C

    SOURCE GeneReport for Unigene cluster: Hs.567374
        SABiosciences Custom PCR Arrays for EIF3C
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of eukaryotes.

    Orthologs for EIF3C gene from 10/24 species (see all 24)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Eif3c1 , 5 eukaryotic translation initiation factor 3, subunit more1, 5 89.24(n)1
    96.93(a)1
      7 (69.14 cM)5
    563471  NM_146200.11  NP_666312.11 
     1265464555 
    chicken
    (Gallus gallus)
    Aves --
    --
    85(a)
    1 → many
    AADN03017869.1(21-1246)
    lizard
    (Anolis carolinensis)
    Reptilia --
    --
    85(a)
    1 → many
    GL343287.1(713980-729556)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.79352 Xenopus laevis, clone IMAGE5543333, mRNA 81.22(n)    BC046704.1 
    zebrafish
    (Danio rerio)
    Actinopterygii Dr.283122 Danio rerio cDNA clone MGC66128 IMAGE2642152, complete more 78.57(n)    BC057465.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta eIF3-S81 CG4954-PA 60.38(n)
    54.6(a)
      37005  NM_137398.1  NP_611242.1 
    worm
    (Caenorhabditis elegans)
    Secernentea eif-3.C1 Protein EIF-3.C 53.01(n)
    46.95(a)
      172858  NM_060237.2  NP_492638.1 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes NIP1(YMR309C)4
    NIP11
    eIF3c subunit of the eukaryotic translation initiation more4
    Nip1p1
    42.68(n)1
    31.82(a)1
      13(895426-892988)4
    8553571, 4  NP_014040.11, 4 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons EIF3C1 translation initiation factor eIF-3 subunit 8 51.97(n)
    43.59(a)
      824781  NM_001203173.1  NP_001190102.1 
    rice
    (Oryza sativa)
    Liliopsida Os07g01245001 hypothetical protein 50.58(n)
    42.15(a)
      4342306  NM_001065339.1  NP_001058804.1 


    ENSEMBL Gene Tree for EIF3C (if available)
    TreeFam Gene Tree for EIF3C (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for EIF3C gene
    EIF3CL1 2  
    1 SIMAP similar gene for EIF3C using alignment to 14 protein entries:     EIF3C_HUMAN (see all proteins):
    EIF3CL

    EIF3C for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/158 SNPs in EIF3C are shown (see all 158)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 16 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1446053201,2
    --28700213(+) TTTGCA/GTGTGT 1 -- int10--------
    rs1475440841,2
    --28700229(+) TGTGTA/GTGTGT 1 -- int10--------
    rs1485764461,2
    --28700241(+) TGTGTG/TTGTGT 1 -- int10--------
    rs3758124961,2
    C--28700549(+) TAGAGC/TCTCTT 1 -- int10--------
    rs2020141061,2
    C--28702943(+) TCAGCA/TGGTAC 1 -- int10--------
    rs3721775421,2
    C--28703436(+) CACAGA/CATATG 1 -- int10--------
    rs2011258491,2
    C--28704057(+) GTCTGA/GGCGAC 1 -- int10--------
    rs2016512621,2
    C--28705407(+) CAGGCA/GTGGTG 1 -- int10--------
    rs2003538771,2
    C--28705419(+) CTCACA/GCCTAT 1 -- int10--------
    rs2009192101,2
    C--28705456(+) TAGGCA/GGATCA 1 -- int10--------

    HapMap Linkage Disequilibrium report for EIF3C (28699879 - 28747051 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 10/20 variations for EIF3C (see all 20):    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv821114CNV Deletion20802225
    nsv820432CNV Deletion20802225
    nsv1776CNV Loss18451855
    nsv511572CNV Loss21212237
    nsv905700CNV Loss21882294
    nsv510683CNV Loss20534489
    nsv833180CNV Loss17160897
    nsv905699CNV Loss21882294
    esv999954CNV Loss20482838
    nsv905698CNV Gain21882294

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 603916    OMIM disorders: --

    9 diseases for EIF3C:    About MalaCards
    fanconi's anemia    colon adenocarcinoma    inflammatory bowel disease    crohn's disease
    anemia    hepatitis c    gastric cancer    adenocarcinoma
    hepatitis


    EIF3C for disorders           About GeneDecksing

    Genetic Association Database (GAD): EIF3C

    Export disorders for EIF3C gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for EIF3C gene, integrated from 9 sources (see all 71):
    (articles sorted by number of sources associating them with EIF3C)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Conservation and diversity of eukaryotic translation initiation factor eIF3. (PubMed id 8995409)1, 2, 3 Asano K....Hershey J.W. (1997)
    2. Common variants at five new loci associated with earl y-onset inflammatory bowel disease. (PubMed id 19915574)1, 4 Imielinski M....McGovern D. (2009)
    3. Mass spectrometry reveals modularity and a complete subunit interaction map of the eukaryotic translation factor eIF3. (PubMed id 18599441)1, 2 Zhou M....Robinson C.V. (2008)
    4. Reconstitution reveals the functional core of mammalian eIF3. (PubMed id 17581632)1, 2 Masutani M.... Imataka H. (2007)
    5. Structural characterization of the human eukaryotic initiation factor 3 protein complex by mass spectrometry. (PubMed id 17322308)1, 2 Damoc E....Leary J.A. (2007)
    6. mTOR and S6K1 mediate assembly of the translation preinitiation complex through dynamic protein interchange and ordered phosphorylation events. (PubMed id 16286006)1, 2 Holz M.K.... Blenis J. (2005)
    7. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    8. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    9. Characterization of eIF3k: a newly discovered subunit of mammalian translation initiation factor elF3. (PubMed id 14519125)1, 2 Mayeur G.L....Hershey J.W. (2003)
    10. Genome duplications and other features in 12 Mb of DNA sequence from human chromosome 16p and 16q. (PubMed id 10493829)1, 2 Loftus B.J.... Adams M.D. (1999)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 8663 HGNC: 3279 AceView: EIF3S8.2 Ensembl:ENSG00000184110 euGenes: HUgn8663
    ECgene: EIF3C Kegg: 8663 H-InvDB: EIF3C

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for EIF3C Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for EIF3C Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for EIF3C gene:
    Search GeneIP for patents involving EIF3C

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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