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EIF3C Gene

protein-coding   GIFtS: 60
GCID: GC16P028700

Eukaryotic Translation Initiation Factor 3, Subunit C

(Previous names: eukaryotic translation initiation factor 3, subunit 8, 11...)
(Previous symbol: EIF3S8)
  Search for EIF3C
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Eukaryotic Translation Initiation Factor 3, Subunit C1 2     Cell Migration-Inducing Protein 172
EIF3S81 2 3 5     eIF3-p1102
Eukaryotic Translation Initiation Factor 3, Subunit 8, 110kDa1 2     Eukaryotic Translation Initiation Factor 3 Subunit C2
Eukaryotic Translation Initiation Factor 3 Subunit 82 3     Eukaryotic Translation Initiation Factor 3, Subunit 8 (110kD)2
EIF3 P1102 3     eIF3c3
EIF3CL2     

External Ids:    HGNC: 32791   Entrez Gene: 86632   Ensembl: ENSG000001841107   OMIM: 6039165   UniProtKB: Q996133   

Export aliases for EIF3C gene to outside databases

Previous GC identifers: GC16P028631 GC16P028723 GC16M026450


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for EIF3C Gene:
EIF3C (eukaryotic translation initiation factor 3, subunit C) is a protein-coding gene. GO annotations related to this gene include translation initiation factor binding and translation initiation factor activity. An important paralog of this gene is EIF3CL.

UniProtKB/Swiss-Prot: EIF3C_HUMAN, Q99613
Function: Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for
several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and
facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S preinitiation
complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG
recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal
complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation

Gene Wiki entry for EIF3C Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000016.9  NC_018927.2  NT_187260.1  
Regulatory elements:
   Regulatory transcription factor binding sites in the EIF3C gene promoter:
         NF-1/L   NF-1   GATA-3   HSF1 (long)   GATA-1   GATA-2   PPAR-alpha   HSF2   c-Myb   HSF1short   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidEIF3C promoter sequence
   Search Chromatin IP Primers for EIF3C

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat EIF3C


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 16p11.2   Ensembl cytogenetic band:  16p11.2   HGNC cytogenetic band: 16p11.2

EIF3C Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
EIF3C gene location

GeneLoc information about chromosome 16         GeneLoc Exon Structure

GeneLoc location for GC16P028700:  view genomic region     (about GC identifiers)

Start:
28,699,879 bp from pter      End:
28,747,051 bp from pter
Size:
47,173 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: EIF3C_HUMAN, Q99613 (See protein sequence)
Recommended Name: Eukaryotic translation initiation factor 3 subunit C  
Size: 913 amino acids; 105344 Da
Subunit: Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is composed of 13
subunits: EIF3A, EIF3B, EIF3C, EIF3D, EIF3E, EIF3F, EIF3G, EIF3H, EIF3I, EIF3J, EIF3K, EIF3L and EIF3M. The eIF-3
complex appears to include 3 stable modules: module A is composed of EIF3A, EIF3B, EIF3G and EIF3I; module B is
composed of EIF3F, EIF3H, and EIF3M; and module C is composed of EIF3C, EIF3D, EIF3E, EIF3K and EIF3L. EIF3C of
module C binds EIF3B of module A and EIF3H of module B, thereby linking the three modules. EIF3J is a labile
subunit that binds to the eIF-3 complex via EIF3B. The eIF-3 complex interacts with RPS6KB1 under conditions of
nutrient depletion. Mitogenic stimulation leads to binding and activation of a complex composed of MTOR and
RPTOR, leading to phosphorylation and release of RPS6KB1 and binding of EIF4B to eIF-3. Identified in a HCV
IRES-mediated translation complex, at least composed of EIF3C, IGF2BP1, RPS3 and HCV RNA-replicon. Interacts with
ALKBH4, IFIT1 and IFIT2
Mass spectrometry: Mass=106143.8; Method=Unknown; Range=1-913; Source=PubMed:17322308;
Mass spectrometry: Mass=106855; Mass_error=40; Method=MALDI; Range=1-913; Source=PubMed:18599441;
Secondary accessions: A8K7Z0 B2RXG3 O00215 Q9BW98

Explore the universe of human proteins at neXtProt for EIF3C: NX_Q99613

Explore proteomics data for EIF3C at MOPED

Post-translational modifications: 

  • Phosphorylated. Phosphorylation is enhanced upon serum stimulation1
  • Ubiquitination2 at Lys493, Lys643, Lys712, Lys742, Lys760, Lys862, Lys877, Lys894
  • Modification sites at PhosphoSitePlus

  • See EIF3C Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (5 alternative transcripts): 
    NP_001032897.1  NP_001186071.1  NP_001254503.1  NP_001273407.1  NP_003743.1  

    ENSEMBL proteins: 
     ENSP00000457963   ENSP00000332604   ENSP00000455278   ENSP00000456416   ENSP00000457418  
     ENSP00000457389   ENSP00000455277   ENSP00000378953  
    Reactome Protein details: Q99613

    EIF3C Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
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    Novus Biologicals EIF3C Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for EIF3C

     
    Search eBioscience for Proteins for EIF3C 

    EIF3C Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
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    ThermoFisher Antibodies for EIF3C
    LSBio Antibodies in human, mouse, rat for EIF3C

    EIF3C Assay Products:

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    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for EIF3C
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    Search eBioscience for ELISAs for EIF3C 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    4 InterPro protein domains:
     IPR000717 PCI_dom
     IPR011991 WHTH_DNA-bd_dom
     IPR027516 EIF3C
     IPR008905 EIF3C_N_dom

    Graphical View of Domain Structure for InterPro Entry Q99613

    ProtoNet protein and cluster: Q99613

    2 Blocks protein domains:
    IPB000717 Domain in components of the proteasome
    IPB008905 Eukaryotic translation initiation factor 3 subunit 8


    UniProtKB/Swiss-Prot: EIF3C_HUMAN, Q99613
    Similarity: Belongs to the eIF-3 subunit C family
    Similarity: Contains 1 PCI domain


    Find genes that share domains with EIF3C           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: EIF3C_HUMAN, Q99613
    Function: Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for
    several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and
    facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S preinitiation
    complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG
    recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal
    complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation

         Gene Ontology (GO): 5 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003743contributes to translation initiation factor activity IDA17581632
    GO:0005488binding ----
    GO:0005515protein binding IPI18628297
    GO:0031369translation initiation factor binding IEA--
    GO:0044822poly(A) RNA binding IDA--
         
    Find genes that share ontologies with EIF3C           About GenesLikeMe


    Phenotypes:
         9 GenomeRNAi human phenotypes for EIF3C:
     Decreased G3BP1 protein expres  Decreased influenza A H1N1 (A/  Decreased influenza A/WSN/33 r  Decreased nuclei size in G2M 
     Decreased viability of wild-ty  Increased S DNA content  Increased cell death in HCT116  S arrest 
     Synthetic lethal with Ras 

         7 MGI mutant phenotypes (inferred from 3 alleles(MGI details for Eif3c):
     craniofacial  growth/size/body  hearing/vestibular/ear  integument  limbs/digits/tail 
     mortality/aging  pigmentation 

    Find genes that share phenotypes with EIF3C           About GenesLikeMe

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for EIF3C
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for EIF3C

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for EIF3C
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for EIF3C

    miRNA
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    miRTarBase miRNAs that target EIF3C:
    hsa-mir-425-5p (MIRT039309), hsa-mir-92a-3p (MIRT049027), hsa-mir-615-3p (MIRT039669), hsa-mir-877-3p (MIRT036996), hsa-let-7a-5p (MIRT052417), hsa-mir-320c (MIRT036164), hsa-mir-155-5p (MIRT020535), hsa-mir-1226-3p (MIRT036476), hsa-mir-16-5p (MIRT031415), hsa-mir-361-5p (MIRT044100), hsa-mir-423-3p (MIRT042529), hsa-mir-186-5p (MIRT044937), hsa-let-7f-5p (MIRT051357), hsa-let-7c-5p (MIRT051775), hsa-mir-149-5p (MIRT045450), hsa-let-7b-5p (MIRT051944), hsa-mir-320a (MIRT044779), hsa-mir-181b-5p (MIRT047297), hsa-mir-99b-3p (MIRT038530)

    Block miRNA regulation of human, mouse, rat EIF3C using miScript Target Protectors
    2 qRT-PCR Assays for microRNAs that regulate EIF3C:
    hsa-miR-196a* hsa-miR-3117-3p
    SwitchGear 3'UTR luciferase reporter plasmidEIF3C 3' UTR sequence
    Inhib. RNA
    Products:
        
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    Predesigned siRNA for gene silencing in human, mouse, rat EIF3C

    Gene Editing
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    GenScript: all cDNA clones in your preferred vector (see all 3): EIF3C (NM_003752)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for EIF3C
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat EIF3C

    Cell Line
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    Browse ESI BIO Cell Lines and PureStem Progenitors for EIF3C 
    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for EIF3C


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    EIF3C_HUMAN, Q99613: Cytoplasm (By similarity)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol4
    nucleus2

    Gene Ontology (GO): 4 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005829cytosol TAS--
    GO:0005852eukaryotic translation initiation factor 3 complex IDA17322308
    GO:0016282eukaryotic 43S preinitiation complex IEA--
    GO:0033290eukaryotic 48S preinitiation complex IEA--

    Find genes that share ontologies with EIF3C           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for EIF3C About   (see all 7)  
    See pathways by source

    SuperPathContained pathways About
    1Influenza Viral RNA Transcription and Replication
    L13a-mediated translational silencing of Ceruloplasmin expression0.94
    Cap-dependent Translation Initiation0.89
    Formation of a pool of free 40S subunits0.94
    Eukaryotic Translation Initiation0.89
    GTP hydrolysis and joining of the 60S ribosomal subunit0.93
    Translation0.82
    2Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S
    Translation initiation complex formation0.91
    Formation of the ternary complex, and subsequently, the 43S complex0.91
    Ribosomal scanning and start codon recognition0.91
    Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S0.90
    3Gene Expression
    Gene Expression0.40
    4Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein
    Metabolism of proteins0.30
    5Translational Control
    Translational Control


    Find genes that share SuperPaths with EIF3C           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    2 Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for EIF3C
        eIF2 Pathway
    mTOR Pathway

    1 Cell Signaling Technology (CST) Pathway for EIF3C
        Translational Control

    1 BioSystems Pathway for EIF3C
        Translation Factors

    Selected Reactome Pathways for EIF3C (see all 6)
        Formation of the ternary complex, and subsequently, the 43S complex
    L13a-mediated translational silencing of Ceruloplasmin expression
    GTP hydrolysis and joining of the 60S ribosomal subunit
    Ribosomal scanning and start codon recognition
    Formation of a pool of free 40S subunits


    1 Kegg Pathway  (Kegg details for EIF3C):
        RNA transport

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for EIF3C
    Interactions:

        Search GeneGlobe Interaction Network for EIF3C

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for EIF3C (Q996131, 2, 3 ENSP000003326044) via UniProtKB, MINT, STRING, and/or I2D (see all 191)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    EIF3BP558842, 3, ENSP000003541254MINT-6948891 I2D: score=6 STRING: ENSP00000354125
    AAGABQ6PD742, 3, ENSP000002618804MINT-64673 I2D: score=5 STRING: ENSP00000261880
    EIF3FO003032, 3, ENSP000003100404MINT-6948891 I2D: score=1 STRING: ENSP00000310040
    SMAD9O151982, 3MINT-62117 I2D: score=3 
    SNIP1Q8TAD82, 3MINT-62165 I2D: score=3 
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001731formation of translation preinitiation complex IEA--
    GO:0006412translation TAS--
    GO:0006413translational initiation TAS--
    GO:0006446regulation of translational initiation IEA--
    GO:0010467gene expression TAS--

    Find genes that share ontologies with EIF3C           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for EIF3C



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for EIF3C gene (5 alternative transcripts): 
    NM_001037808.2  NM_001199142.1  NM_001267574.2  NM_001286478.1  NM_003752.4  

    Unigene Cluster for EIF3C:

    Eukaryotic translation initiation factor 3, subunit C
    Hs.567374  [show with all ESTs]
    Unigene Representative Sequence: NM_001199142
    14 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000566501(uc010byi.3) ENST00000331666(uc002dqs.4 uc010vcy.2)
    ENST00000569690 ENST00000564243 ENST00000566866 ENST00000563139 ENST00000568426
    ENST00000565099 ENST00000565932(uc002dqv.4) ENST00000564839 ENST00000566519
    ENST00000569005 ENST00000566086 ENST00000395587(uc002dqt.4 uc010byj.3 uc002dqu.4)

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    2 qRT-PCR Assays for microRNAs that regulate EIF3C:
    hsa-miR-196a* hsa-miR-3117-3p
    SwitchGear 3'UTR luciferase reporter plasmidEIF3C 3' UTR sequence
    Inhib. RNA
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    GenScript: all cDNA clones in your preferred vector (see all 3): EIF3C (NM_003752)
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat EIF3C
    Primer
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      QuantiTect SYBR Green Assays in human, mouse, rat EIF3C
      QuantiFast Probe-based Assays in human, mouse, rat EIF3C

    Additional mRNA sequence: 

    AK000739.1 AK055366.1 AK130531.1 AK292155.1 AK293264.1 AK299421.1 AK301183.1 AK301233.1 
    AK303790.1 AK304500.1 AY762099.1 BC000533.2 BC001571.1 BC071705.1 BC107692.1 BC157842.1 
    BC157849.1 BT007335.1 

    Selected DOTS entries (see all 92):

    DT.100657002  DT.92471241  DT.91907929  DT.120695317  DT.100686649  DT.120695631  DT.95213205  DT.120695342 
    DT.120696091  DT.95260779  DT.100686677  DT.100686656  DT.100686652  DT.100686662  DT.120695984  DT.120697057 
    DT.91921517  DT.95260843  DT.120696153  DT.91801554  DT.120696456  DT.120697280  DT.120695460  DT.120696319 

    Selected AceView cDNA sequences (see all 1582):

    AW246841 CR596433 BQ879218 BQ893551 BX422004 BE408092 CR598030 BU153736 
    BU501260 BG764010 AI223809 BQ681824 BU184389 BQ646402 BE258356 BE464950 
    BQ675931 AW384014 BE250830 AI190284 BE296574 BU624910 AW246666 CA392160 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for EIF3C (see all 14)    About this scheme

    ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3 ^ 4 ^ 5a · 5b · 5c ^ 6a · 6b ^ 7 ^ 8 ^ 9a · 9b ^ 10 ^ 11 ^ 12a · 12b · 12c · 12d ^ 13 ^ 14a · 14b · 14c ^
    SP1:                    -     -                                                                       -     -     -                                             
    SP2:                    -     -                             -     -                                   -     -     -                                             
    SP3:                                                                                                  -     -     -                                             
    SP4:                                                                                                                                                            
    SP5:                    -     -                       -     -     -     -     -     -     -     -     -     -     -     -     -     -     -     -     -     -   

    ExUns: 15a · 15b ^ 16 ^ 17a · 17b ^ 18a · 18b · 18c ^ 19a · 19b · 19c ^ 20 ^ 21a · 21b ^ 22 ^ 23a · 23b ^ 24a · 24b
    SP1:                                                                                                                  
    SP2:                                                                                                                  
    SP3:                                                                                                                  
    SP4:                                                                                                                  
    SP5:  -     -     -     -     -     -                                                                                 


    ECgene alternative splicing isoforms for EIF3C

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

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    EIF3C expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CGCCGCGGTG
    EIF3C Expression
    About this image


    EIF3C expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 5) fully expand
     
     Brain (Nervous System)    fully expand to see all 4 entries
             Cerebral Cortex
     
     Trophoblast (Extraembryonic Tissues)
             Trophoblast Cells Trophoblast
     
     Ovary (Reproductive System)
             Oviduct
     
     Bone (Muscoskeletal System)
             Bone Marrow
     
     Limb (Muscoskeletal System)
    EIF3C Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    EIF3C Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.567374
        Custom PCR Arrays for EIF3C
    Primer
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for EIF3C

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of eukaryotes.

    Orthologs for EIF3C gene from Selected species (see all 24)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Eif3c1 , 5 eukaryotic translation initiation factor 3, subunit more1, 5 89.24(n)1
    96.93(a)1
      7 (69.14 cM)5
    563471  NM_146200.11  NP_666312.11 
     1265464555 
    chicken
    (Gallus gallus)
    Aves --
    Uncharacterized protein
    87(a)
    1 → many
    AADN03017869.1(21-1246)
    lizard
    (Anolis carolinensis)
    Reptilia --
    Eukaryotic translation initiation factor 3 subunit...
    87(a)
    1 → many
    GL343287.1(713980-729556)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.79352 Xenopus laevis, clone IMAGE5543333, mRNA 81.22(n)    BC046704.1 
    zebrafish
    (Danio rerio)
    Actinopterygii Dr.283122 Danio rerio cDNA clone MGC66128 IMAGE2642152, complete more 78.57(n)    BC057465.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta eIF3-S81 eIF3-S8 60.38(n)
    53.55(a)
      37005  NM_137398.1  NP_611242.1 
    worm
    (Caenorhabditis elegans)
    Secernentea eif-3.C1 eif-3.C 52.56(n)
    47.52(a)
      172858  NM_060237.3  NP_492638.1 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes NIP1(YMR309C)4
    NIP11
    eIF3c subunit of the eukaryotic translation initiation more4
    NIP11
    43.45(n)1
    33.39(a)1
      13(895426-892988)4
    8553571, 4  NP_014040.11, 4 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons EIF3C1 EIF3C 52.75(n)
    43.73(a)
      824781  NM_001203173.1  NP_001190102.1 
    rice
    (Oryza sativa)
    Liliopsida Os07g01245001 Os07g0124500 51.08(n)
    43.04(a)
      4342306  NM_001065339.1  NP_001058804.1 


    ENSEMBL Gene Tree for EIF3C (if available)
    TreeFam Gene Tree for EIF3C (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for EIF3C gene
    EIF3CL2  
    1 SIMAP similar gene for EIF3C using alignment to 14 protein entries:     EIF3C_HUMAN (see all proteins):
    EIF3CL

    Find genes that share paralogs with EIF3C           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for EIF3C (see all 158)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 16 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1446053201,2
    --28700213(+) TTTGCA/GTGTGT 1 -- int10--------
    rs1475440841,2
    --28700229(+) TGTGTA/GTGTGT 1 -- int10--------
    rs1485764461,2
    --28700241(+) TGTGTG/TTGTGT 1 -- int10--------
    rs3758124961,2
    C--28700549(+) TAGAGC/TCTCTT 1 -- int10--------
    rs2020141061,2
    C--28702943(+) TCAGCA/TGGTAC 1 -- int10--------
    rs3721775421,2
    C--28703436(+) CACAGA/CATATG 1 -- int10--------
    rs2011258491,2
    C--28704057(+) GTCTGA/GGCGAC 1 -- int10--------
    rs2016512621,2
    C--28705407(+) CAGGCA/GTGGTG 1 -- int10--------
    rs2003538771,2
    C--28705419(+) CTCACA/GCCTAT 1 -- int10--------
    rs2009192101,2
    C--28705456(+) TAGGCA/GGATCA 1 -- int10--------

    HapMap Linkage Disequilibrium report for EIF3C (28699879 - 28747051 bp)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for EIF3C (see all 20):    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv821114CNV Deletion20802225
    nsv820432CNV Deletion20802225
    nsv1776CNV Loss18451855
    nsv511572CNV Loss21212237
    nsv905700CNV Loss21882294
    nsv510683CNV Loss20534489
    nsv833180CNV Loss17160897
    nsv905699CNV Loss21882294
    esv999954CNV Loss20482838
    nsv905698CNV Gain21882294

    Human Gene Mutation Database (HGMD): EIF3C
    Site Specific Mutation Identification with PCR Assays
    Search QIAGEN SeqTarget long-range PCR primers for resequencing EIF3C
    DNA2.0 Custom Variant and Variant Library Synthesis for EIF3C

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 603916    OMIM disorders: --


    Find genes that share disorders with EIF3C           About GenesLikeMe

    Genetic Association Database (GAD): EIF3C

    Export disorders for EIF3C gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for EIF3C gene, integrated from 10 sources (see all 73):
    (articles sorted by number of sources associating them with EIF3C)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Conservation and diversity of eukaryotic translation initiation factor eIF3. (PubMed id 8995409)1, 2, 3 Asano K.... Hershey J.W.B. (J. Biol. Chem. 1997)
    2. Common variants at five new loci associated with early-onset inflammatory bowel disease. (PubMed id 19915574)1, 4 Imielinski M....Hakonarson H. (Nat. Genet. 2009)
    3. Mass spectrometry reveals modularity and a complete subunit interaction map of the eukaryotic translation factor eIF3. (PubMed id 18599441)1, 2 Zhou M.... Robinson C.V. (Proc. Natl. Acad. Sci. U.S.A. 2008)
    4. Reconstitution reveals the functional core of mammalian eIF3. (PubMed id 17581632)1, 2 Masutani M.... Imataka H. (EMBO J. 2007)
    5. Structural characterization of the human eukaryotic initiation factor 3 protein complex by mass spectrometry. (PubMed id 17322308)1, 2 Damoc E.... Leary J.A. (Mol. Cell. Proteomics 2007)
    6. mTOR and S6K1 mediate assembly of the translation preinitiation complex through dynamic protein interchange and ordered phosphorylation events. (PubMed id 16286006)1, 2 Holz M.K.... Blenis J. (Cell 2005)
    7. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    8. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    9. Characterization of eIF3k: a newly discovered subunit of mammalian translation initiation factor eIF3. (PubMed id 14519125)1, 2 Mayeur G.L.... Hershey J.W.B. (Eur. J. Biochem. 2003)
    10. Genome duplications and other features in 12 Mb of DNA sequence from human chromosome 16p and 16q. (PubMed id 10493829)1, 2 Loftus B.J.... Adams M.D. (Genomics 1999)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 8663 HGNC: 3279 AceView: EIF3S8.2 Ensembl:ENSG00000184110 euGenes: HUgn8663
    ECgene: EIF3C Kegg: 8663 H-InvDB: EIF3C

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for EIF3C Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for EIF3C Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for EIF3C gene:
    Search GeneIP for patents involving EIF3C

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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