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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

EIF3B Gene

protein-coding   GIFtS: 59
GCID: GC07P002362

Eukaryotic Translation Initiation Factor 3, Subunit B

(Previous names: eukaryotic translation initiation factor 3, subunit 9 eta,...)
(Previous symbol: EIF3S9)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Eukaryotic Translation Initiation Factor 3, Subunit B1 2     hPrt12 3
EIF3S91 2 3 5     PRT12 5
Eukaryotic Translation Initiation Factor 3, Subunit 9 Eta, 116kDa1 2     EIF3-ETA2
Eukaryotic Translation Initiation Factor 3 Subunit 92 3     EIF3-P1102
Prt1 Homolog2 3     EIF3-P1162
eIF-3-eta2 3     Eukaryotic Translation Initiation Factor 3 Subunit B2
EIF3 P1102 3     Eukaryotic Translation Initiation Factor 3, Subunit 9 (Eta, 116kD)2
EIF3 P1162 3     eIF3b3

External Ids:    HGNC: 32801   Entrez Gene: 86622   Ensembl: ENSG000001062637   OMIM: 6039175   UniProtKB: P558843   

Export aliases for EIF3B gene to outside databases


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for EIF3B Gene: 
EIF3B (eukaryotic translation initiation factor 3, subunit B) is a protein-coding gene. Diseases associated with EIF3B include mouth disease, and tetralogy of fallot, and among its related super-pathways are Eukaryotic Translation Initiation and Formation of the ternary complex, and subsequently, the 43S complex. GO annotations related to this gene include protein complex scaffold and nucleotide binding.

UniProtKB/Swiss-Prot: EIF3B_HUMAN, P55884
Function: Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for
several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and
facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S preinitiation
complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG
recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal
complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation

Gene Wiki entry for EIF3B Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000007.13  NC_018918.2  NT_007819.17  NT_079592.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the EIF3B gene promoter:
         Max1   Pax-5   NF-E2 p45   Egr-4   AREB6   Pax-4a   NF-E2   ATF   ATF6   c-Myc   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 11): EIF3B promoter sequence
   Search SABiosciences Chromatin IP Primers for EIF3B

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat EIF3B


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 7p22.3   Ensembl cytogenetic band:  7p22.3   HGNC cytogenetic band: 7p22

EIF3B Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
EIF3B gene location

GeneLoc information about chromosome 7         GeneLoc Exon Structure

GeneLoc location for GC07P002362:  view genomic region     (about GC identifiers)

Start:
2,393,721 bp from pter      End:
2,420,380 bp from pter
Size:
26,660 bases      Orientation:
plus strand

1 alternative location:
Chr7+,CRA_TCAG 2,442,541-2,468,274     

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: EIF3B_HUMAN, P55884 (See protein sequence)
Recommended Name: Eukaryotic translation initiation factor 3 subunit B  
Size: 814 amino acids; 92482 Da
Subunit: Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is composed of 13
subunits: EIF3A, EIF3B, EIF3C, EIF3D, EIF3E, EIF3F, EIF3G, EIF3H, EIF3I, EIF3J, EIF3K, EIF3L and EIF3M. The eIF-3
complex appears to include 3 stable modules: module A is composed of EIF3A, EIF3B, EIF3G and EIF3I; module B is
composed of EIF3F, EIF3H, and EIF3M; and module C is composed of EIF3C, EIF3D, EIF3E, EIF3K and EIF3L. EIF3C of
module C binds EIF3B of module A and EIF3H of module B, thereby linking the three modules. EIF3J is a labile
subunit that binds to the eIF-3 complex via EIF3B. The eIF-3 complex interacts with RPS6KB1 under conditions of
nutrient depletion. Mitogenic stimulation leads to binding and activation of a complex composed of MTOR and
RPTOR, leading to phosphorylation and release of RPS6KB1 and binding of EIF4B to eIF-3. Also interacts with UPF2
Subcellular location: Cytoplasm (By similarity)
Mass spectrometry: Mass=93093.7; Method=Unknown; Range=1-814; Source=PubMed:17322308;
Mass spectrometry: Mass=92561; Mass_error=43.5; Method=MALDI; Range=1-814; Source=PubMed:18599441;
2 PDB 3D structures from and Proteopedia for EIF3B:
2KRB (3D)        2NLW (3D)    
Secondary accessions: A4D208 Q2NL77 Q9UMF9
Alternative splicing: 2 isoforms:  P55884-1   P55884-2   

Explore the universe of human proteins at neXtProt for EIF3B: NX_P55884

Explore proteomics data for EIF3B at MOPED 

Post-translational modifications:

  • UniProtKB: Phosphorylated. Phosphorylation is enhanced upon serum stimulation
  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_P55884

  • EIF3B Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    EIF3B Protein Expression
    REFSEQ proteins (2 alternative transcripts): 
    NP_001032360.1  NP_003742.2  

    ENSEMBL proteins: 
     ENSP00000408062   ENSP00000354125   ENSP00000407785   ENSP00000380206  
    Reactome Protein details: P55884
    Human Recombinant Protein Products for EIF3B: 
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    Cloud-Clone Corp. Proteins for EIF3B 

    Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005829cytosol TAS--
    GO:0005852eukaryotic translation initiation factor 3 complex IDA17322308
    GO:0016282eukaryotic 43S preinitiation complex IEA--
    GO:0033290eukaryotic 48S preinitiation complex IEA--

    EIF3B for ontologies           About GeneDecksing



    EIF3B Antibody Products: 
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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    RBM: RNA binding motif (RRM) containing

    5 InterPro protein domains:
     IPR013979 TIF_beta_prop-like
     IPR000504 RRM_dom
     IPR012677 Nucleotide-bd_a/b_plait
     IPR015943 WD40/YVTN_repeat-like_dom
     IPR011400 EIF3B

    Graphical View of Domain Structure for InterPro Entry P55884

    ProtoNet protein and cluster: P55884

    2 Blocks protein domains:
    IPB000504 RNA-binding region RNP-1 (RNA recognition motif)
    IPB013979 Eukaryotic translation initiation factor 2A


    UniProtKB/Swiss-Prot: EIF3B_HUMAN, P55884
    Domain: The RRM domain mediates interaction with EIF3J
    Similarity: Belongs to the eIF-3 subunit B family
    Similarity: Contains 1 RRM (RNA recognition motif) domain
    Similarity: Contains 5 WD repeats


    EIF3B for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: EIF3B_HUMAN, P55884
    Function: Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for
    several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and
    facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S preinitiation
    complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG
    recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal
    complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation

         Gene Ontology (GO): 5/7 molecular function terms (GO ID links to tree view) (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000166nucleotide binding IEA--
    GO:0003676nucleic acid binding ----
    GO:0003723RNA binding ----
    GO:0003743contributes to translation initiation factor activity IDA17581632
    GO:0005515protein binding IPI11169732
         
    EIF3B for ontologies           About GeneDecksing


    Phenotypes:
         5 GenomeRNAi human phenotypes for EIF3B:
     Decreased G3BP1 protein expres  Decreased viability of wild-ty  Increased cell death in HCT116  Nuclear 60S biogenesis defects 
     Nucleolar pre-40S maturation d 

    Animal Models:
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for EIF3B 
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    SwitchGear 3'UTR luciferase reporter plasmidEIF3B 3' UTR sequence
    Inhib. RNA
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for EIF3B


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for EIF3B About   (see all 6)                                                                                              See pathways by source

    SuperPathContained pathways About
    1Viral mRNA Translation
    GTP hydrolysis and joining of the 60S ribosomal subunit0.94
    L13a-mediated translational silencing of Ceruloplasmin expression0.93
    Eukaryotic Translation Initiation0.94
    Formation of a pool of free 40S subunits0.90
    Cap-dependent Translation Initiation0.94
    Translation0.78
    3' -UTR-mediated translational regulation0.93
    2Translation initiation complex formation
    Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S0.95
    Formation of the ternary complex, and subsequently, the 43S complex0.87
    Ribosomal scanning and start codon recognition0.95
    Translation initiation complex formation0.87
    3Generic Transcription Pathway
    Gene Expression0.47
    4Asparagine N-linked glycosylation
    Metabolism of proteins0.35
    5Translation Factors
    Translation Factors

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 BioSystems Pathway for EIF3B
        Translation Factors

    5/13        Reactome Pathways for EIF3B (see all 13)
        Formation of the ternary complex, and subsequently, the 43S complex
    Translation
    GTP hydrolysis and joining of the 60S ribosomal subunit
    Eukaryotic Translation Initiation
    Ribosomal scanning and start codon recognition


    1         Kegg Pathway  (Kegg details for EIF3B):
        RNA transport


    EIF3B for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for EIF3B

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/762 Interacting proteins for EIF3B (P558841, 2, 3 ENSP000003541254) via UniProtKB, MINT, STRING, and/or I2D (see all 762)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    HIST1H4AP628053I2D: score=1 
    HIST1H4BP628053I2D: score=1 
    HIST1H4CP628053I2D: score=1 
    HIST1H4DP628053I2D: score=1 
    HIST1H4EP628053I2D: score=1 
    About this table

    Gene Ontology (GO): 5/6 biological process terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001731formation of translation preinitiation complex IEA--
    GO:0006412translation TAS--
    GO:0006413translational initiation TAS--
    GO:0006446regulation of translational initiation IDA8995410
    GO:0010467gene expression TAS--

    EIF3B for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for EIF3B

    Search CenterWatch for drugs/clinical trials and news about EIF3B

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for EIF3B gene (2 alternative transcripts): 
    NM_001037283.1  NM_003751.3  

    Unigene Cluster for EIF3B:

    Eukaryotic translation initiation factor 3, subunit B
    Hs.371001  [show with all ESTs]
    Unigene Representative Sequence: AB209381
    12 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000431643 ENST00000360876(uc003slx.3 uc003sly.3 uc003slz.1)
    ENST00000413917 ENST00000397011(uc003sma.3) ENST00000463229 ENST00000463026
    ENST00000468250 ENST00000466199 ENST00000475415 ENST00000468611(uc003smb.3)
    ENST00000465670 ENST00000494658
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    SwitchGear 3'UTR luciferase reporter plasmidEIF3B 3' UTR sequence
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    Additional mRNA sequence: 

    AB209381.1 AK127885.1 AK300967.1 AK302058.1 BC001173.1 BC009986.1 BC110865.1 U62583.1 
    U78525.1 

    24/35 DOTS entries (see all 35):

    DT.100834695  DT.97798019  DT.100759692  DT.95173385  DT.100834690  DT.454061  DT.100730058  DT.429116 
    DT.92462641  DT.97786597  DT.203336  DT.70104982  DT.102836765  DT.100039603  DT.95305235  DT.95148198 
    DT.97864515  DT.121124337  DT.95313948  DT.100834693  DT.121124353  DT.100033517  DT.100834684  DT.100834692 

    24/758 AceView cDNA sequences (see all 758):

    CA313146 AI990399 BQ015102 BM790290 BQ220582 BU539252 BU860027 CF455722 
    BG260460 CA414423 BU184482 BU539785 BG679127 BM904776 CF131575 BQ184896 
    AW402799 BM455055 BM560380 AI160080 CR603885 BQ221471 BG481207 BU631424 

    GeneLoc Exon Structure

    5/18 Alternative Splicing Database (ASD) splice patterns (SP) for EIF3B (see all 18)    About this scheme

    ExUns: 1 ^ 2 ^ 3a · 3b · 3c ^ 4a · 4b ^ 5a · 5b ^ 6a · 6b ^ 7a · 7b ^ 8a · 8b ^ 9a · 9b · 9c ^ 10 ^ 11a · 11b ^ 12a · 12b ^ 13 ^ 14 ^ 15a ·
    SP1:                                                                                            -                             -           -     -               
    SP2:                                                                                            -                             -           -     -               
    SP3:                                                                                            -                             -           -     -               
    SP4:                                                                                            -                             -           -     -               
    SP5:        -     -     -     -                                                                                                                                 

    ExUns: 15b · 15c ^ 16 ^ 17a · 17b ^ 18 ^ 19a · 19b · 19c ^ 20a · 20b ^ 21 ^ 22a · 22b ^ 23a · 23b ^ 24a · 24b · 24c
    SP1:        -           -                 -                                         -     -           -               
    SP2:        -           -                 -                                         -                                 
    SP3:        -           -                 -                                         -     -                           
    SP4:        -           -                 -                                         -     -                           
    SP5:                                                                                                                  


    ECgene alternative splicing isoforms for EIF3B

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    EIF3B expression in normal human tissues (normalized intensities)      EIF3B embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GAAATAAAAG
    EIF3B Expression
    About this image


    EIF3B expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/1 selected tissues (see all 1) fully expand
     
     Heart (Cardiovascular System)
             Outflow Tract

    See EIF3B Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for EIF3B

    SOURCE GeneReport for Unigene cluster: Hs.371001
        SABiosciences Custom PCR Arrays for EIF3B
    Primer
    Products:
    OriGene qPCR primer pairs and template standards for EIF3B
    OriGene qSTAR qPCR primer pairs in human, mouse for EIF3B
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat EIF3B
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat EIF3B
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat EIF3B
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for EIF3B

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of eukaryotes.

    Orthologs for EIF3B gene from 10/25 species (see all 25)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Eif3b1 , 5 eukaryotic translation initiation factor 3, subunit more1, 5 85.68(n)1
    92.51(a)1
      5 (78.97 cM)5
    279791  NM_133916.21  NP_598677.11 
     1404193055 
    chicken
    (Gallus gallus)
    Aves EIF3B1 eukaryotic translation initiation factor 3, subunit more 79.62(n)
    91.02(a)
      769783  XM_003642142.1  XP_003642190.1 
    lizard
    (Anolis carolinensis)
    Reptilia EIF3B6
    --
    Uncharacterized protein
    72(a)
    56(a)
    many → 1
    many → 1
    GL343340.1(41712-52758)
    GL343307.1(1301747-1303336)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.260732 Xenopus laevis transcribed sequence with moderate similarity more 77.37(n)    48055327 
    zebrafish
    (Danio rerio)
    Actinopterygii wufc17c012 wufc17c01 82.82(n)   324028  CA787533.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta eIF3-S91 CG4878-PA 58.47(n)
    53.76(a)
      36981  NM_137384.3  NP_611228.1 
    worm
    (Caenorhabditis elegans)
    Secernentea eif-3.B1 Protein EIF-3.B 46.13(n)
    36.6(a)
      175138  NM_001027298.3  NP_001022469.1 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes PRT1(YOR361C)4
    PRT11
    eIF3b subunit of the core complex of translation initiation more4
    Prt1p1
    47.92(n)1
    34.28(a)1
      15(1017652-1015361)4
    8545431, 4  NP_015006.31  NP_015006.14 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons TIF3B11 translation initiation factor 3 subunit B 53.14(n)
    43.23(a)
      832826  NM_001036877.2  NP_001031954.1 
    rice
    (Oryza sativa)
    Liliopsida Os.48992 Oryza sativa (japonica cultivar-group) cDNA clone0 more 70.36(n)    AK110143.1 


    ENSEMBL Gene Tree for EIF3B (if available)
    TreeFam Gene Tree for EIF3B (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for EIF3B gene
    1 SIMAP similar gene for EIF3B using alignment to 7 protein entries:     EIF3B_HUMAN (see all proteins):
    EIF3S9

    EIF3B for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    703/980 SNPs in EIF3B are shown (see all 980)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 7 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs77959371,2
    C--2392502(+) cttatC/Tgtaca 2 -- us2k10--------
    rs1866445271,2
    --2392544(+) ACCTGC/TCCAAA 2 -- us2k10--------
    rs1911089171,2
    C--2392571(+) CATGAC/TGAGGA 2 -- us2k10--------
    rs1405732621,2
    --2392678(+) AGTCCC/TGGCAC 2 -- us2k10--------
    rs749343721,2
    F--2392748(+) ACACAG/ATGAGA 2 -- us2k11Minor allele frequency- A:0.03NA 120
    rs1457357701,2
    --2392785(+) TGGGCA/GCGGTG 2 -- us2k10--------
    rs624441621,2
    C,F--2392860(+) GCATAT/CTAAAA 2 -- us2k12Minor allele frequency- C:0.08NA 122
    rs1825669971,2
    --2392876(+) AGGCCC/GTGCGC 2 -- us2k10--------
    rs1418556821,2
    --2392881(+) CTGCGC/GGGTGG 2 -- us2k10--------
    rs77929341,2
    C,F--2393016(+) accctG/Atctct 2 -- us2k112Minor allele frequency- A:0.24NA WA CSA EA 374
    rs1129462811,2
    C--2393037(+) AAAAC-/AAAAAA 2 -- us2k11Minor allele frequency- A:0.50CSA 2
    rs1178406401,2
    F--2393209(+) ACCGCG/ACAGGG 2 -- us2k11Minor allele frequency- A:0.05EA 120
    rs1881381801,2
    --2393309(+) ACGTTC/TTCATC 2 -- us2k10--------
    rs69445841,2
    C,F--2393381(+) accacT/Ctgttt 2 -- us2k1 tfbs310Minor allele frequency- C:0.32NA WA CSA EA 371
    rs1506893421,2
    --2393472(+) ACTCCA/TAAGCT 2 -- us2k10--------
    rs1135221991,2
    C,F--2393533(+) ATCCAC/TTGGGT 2 -- us2k12Minor allele frequency- T:0.05CSA WA 120
    rs1389276201,2
    --2393586(+) CCTCCA/TCTCCG 2 -- us2k10--------
    rs1128286271,2
    C,F--2393631(+) GCCCGT/CCCCGT 2 -- us2k12Minor allele frequency- C:0.04CSA WA 119
    rs23986611,2
    C,F,A,H--2393632(-) CACGGT/GACGGG 2 -- us2k113Minor allele frequency- G:0.43NA EA NS WA CSA 668
    rs1929515121,2
    C--2393662(+) CCGCTC/GCGGTC 2 -- us2k10--------
    rs783703581,2
    F--2393773(+) AACCAC/GTGTGA 2 -- us2k11Minor allele frequency- G:0.05WA 118
    rs1851870671,2
    --2393782(+) GAAAGC/GCCGAA 2 -- us2k10--------
    rs1494375931,2
    --2393809(+) GTGACA/GGCCGC 2 -- us2k10--------
    rs1905124911,2
    --2393863(+) TTTTTC/GTATCG 2 -- us2k10--------
    rs78018171,2
    C,F,A,H--2393947(+) GTCTGG/TCCTTT 2 -- us2k123Minor allele frequency- T:0.33NS EA NA WA CSA 2345
    rs1932424941,2
    --2393951(+) GTCCTC/TTTGCT 2 -- us2k10--------
    rs1447598071,2
    --2393979(+) CAAGTA/GACAGA 2 -- us2k10--------
    rs1400895071,2
    --2394041(+) AGGCTC/GAGACG 2 -- us2k10--------
    rs1147494011,2
    F--2394051(+) GCCCTG/CAGCAA 2 -- us2k11Minor allele frequency- C:0.03WA 118
    rs1451195341,2
    --2394093(+) TTAACA/TGTTGA 2 -- us2k10--------
    rs1471783441,2
    --2394112(+) ACATTC/TTCCTA 2 -- us2k10--------
    rs1402729111,2
    --2394199(+) GACGGG/TAAAGG 2 -- us2k10--------
    rs1839569411,2
    --2394210(+) AAAGGA/GGGAGG 2 -- us2k10--------
    rs791984581,2
    C,F--2394263(+) GTCAAT/AGCTCC 2 -- us2k11Minor allele frequency- A:0.01EA 120
    rs1882945121,2
    --2394275(+) ATGAGC/TTTACT 2 -- us2k10--------
    rs1420794581,2
    C--2394284(+) CTGATA/GCACAG 2 -- us2k10--------
    rs23019421,2
    C,F,A,H--2394296(+) AACAAC/TCTTGC 2 -- us2k19Minor allele frequency- T:0.45MN NA CSA WA EA 730
    rs1806979701,2
    --2394314(+) AATTAA/TGCACT 2 -- us2k10--------
    rs23019431,2
    C,F--2394316(+) TTAAGC/GACTTT 2 -- us2k18Minor allele frequency- G:0.21NA WA EA 368
    rs774775471,2
    C--2394332(+) CACAAA/TTATAT 2 -- us2k10--------
    rs1391850981,2
    --2394345(+) GTTTGA/GTGATT 2 -- us2k10--------
    rs676966031,2
    C--2394429(+) CCCCG-/GCGCGGCC 2 -- cds10--------
    rs119752051,2
    C,A,H--2394480(+) AGCCGA/TCGCGG 2 -- ut510--------
    rs96907871,2,4
    C,F,A,H--2394746(+) CGGAGC/TCCGAG 4 P S mis17Minor allele frequency- T:0.30NA WA CSA 131
    rs1857627941,2
    C--2394934(+) TCCGAC/GGACGC 4 D E mis10--------
    rs115511671,2
    C,F--2394991(+) GAGAAC/TGGCGA 4 N syn17Minor allele frequency- T:0.21NA WA EA 366
    rs786807931,2
    C--2395043(+) ACGACG/CTGAGC 4 /L /V mis11Minor allele frequency- C:0.02EU 107
    rs1897318931,2
    --2395095(+) CGGGAG/TCGTGG 2 -- int10--------
    rs1159009001,2
    C--2395105(+) GCTGGA/GGTTCC 2 -- int10--------
    rs1818611181,2
    --2395297(+) AGCCAA/GGCATT 2 -- int10--------
    rs1869307401,2
    --2395440(+) CGTGTC/TCCCAG 2 -- int10--------
    rs1456803171,2
    C--2395468(+) TCCCAA/GGGTCT 2 -- int10--------
    rs38074301,2
    C,F,A,H--2395509(+) GTGATT/CTTGTC 2 -- int119Minor allele frequency- C:0.41NS EA NA CSA WA 2342
    rs1465881991,2
    --2395523(+) CTGCCC/TCTCAG 2 -- int10--------
    rs1145840471,2
    F--2395535(+) ATTGTC/TCATCT 2 -- int11Minor allele frequency- T:0.03WA 118
    rs1921278981,2
    --2395537(+) TGTCCA/GTCTCC 2 -- int10--------
    rs1832479701,2
    --2395594(+) TTTTTC/TTTTAT 2 -- int10--------
    rs1861054291,2
    --2395600(+) TTTATC/TTCTTG 2 -- int10--------
    rs105740561,2
    C--2395615(+) ATCTA-/TAAAGAG 2 -- int10--------
    rs1491696201,2
    --2395634(+) TTTTTC/TCAGGT 2 -- int10--------
    rs1897801201,2
    --2395702(+) AGGCAA/TATTTT 2 -- int10--------
    rs762140451,2
    C--2395724(+) TCAGAG/TATTTT 2 -- int10--------
    rs1482989901,2
    C--2395789(+) TAGCTC/GTCTTA 2 -- int10--------
    rs730433001,2
    C,F--2395884(+) GTAGCC/TAGCGA 2 -- int11Minor allele frequency- T:0.02NA 120
    rs1116362321,2
    C,F--2395986(+) CTCACG/ACCTGT 2 -- int11Minor allele frequency- A:0.50WA 2
    rs2001753721,2
    C--2396019(+) GAGAC-/GGGTGG 2 -- int10--------
    rs1821172811,2
    --2396020(+) AGACGA/GGTGGA 2 -- int10--------
    rs1154104461,2
    F--2396042(+) CCATCC/TTGGCT 2 -- int11Minor allele frequency- T:0.03WA 118
    rs1471241461,2
    C--2396054(+) ACACGA/GTGAAA 2 -- int10--------
    rs1384731111,2
    --2396093(+) TTAGCC/TGGGCG 2 -- int10--------
    rs1881010051,2
    --2396176(+) GAGCTC/TGCAGT 2 -- int10--------
    rs1928770321,2
    C--2396200(+) GCCACA/TGCACT 2 -- int10--------
    rs113957281,2
    C--2396238(+) AAAAAA/-AAAAA 2 -- int1 trp31Minor allele frequency- -:0.00NA 2
    rs1471620481,2
    --2396255(+) AAAAGA/GAAAAG 2 -- int10--------
    rs1835873361,2
    --2396311(+) ACACCC/TGTAGT 2 -- int10--------
    rs1886396301,2
    --2396457(+) AACGCC/TGTCAG 2 -- int10--------
    rs1394973801,2
    --2396472(+) TGTGAC/TCATTA 2 -- int10--------
    rs1160046331,2
    F--2396485(+) ATATTA/TCACTT 2 -- int11Minor allele frequency- T:0.04WA 118
    rs3722315111,2
    C--2396488(+) TTACA-/T/TT  
            
    TTTTT
    2 -- int10--------
    rs1492770241,2
    --2396535(+) AGGACA/TCCACA 2 -- int10--------
    rs69524331,2
    C,F,A,H--2396638(+) GGTCTG/ATACTG 2 -- int124Minor allele frequency- A:0.23NS EA NA WA CSA 1285
    rs1444210471,2
    --2396702(+) TGTTAC/TTATGG 2 -- int10--------
    rs1919573061,2
    --2396727(+) CTTTTC/GGTTTA 2 -- int10--------
    rs1849472381,2
    --2396862(+) TATGAC/TGACAG 2 -- int10--------
    rs1484137581,2
    --2396887(+) GGTGAC/TGGCTG 2 -- int10--------
    rs1426888331,2
    C--2396931(+) TGCAGG/TGTTGG 2 -- int10--------
    rs791313871,2
    F--2397078(+) CGTAGG/CTGACT 2 -- int11Minor allele frequency- C:0.05WA 118
    rs1893253041,2
    --2397109(+) GGCCAA/CGTCTT 2 -- int10--------
    rs1915118461,2
    --2397205(+) TCCTTA/TCAGTT 2 -- int10--------
    rs1465261961,2
    --2397388(+) CAAGGC/TGTTGT 2 -- int10--------
    rs1837011921,2
    --2397520(+) GCAGCC/TTTATA 2 -- int10--------
    rs1897572891,2
    --2397546(+) TGTCAA/GGCTAT 2 -- int10--------
    rs1813390521,2
    --2397557(+) TTAATC/TGTATG 2 -- int10--------
    rs1399111231,2
    C--2397569(+) TAAGTA/GCTTTA 2 -- int10--------
    rs1137001221,2
    F--2397626(+) ACTGCA/GGTGAC 2 -- int12Minor allele frequency- G:0.04CSA WA 120
    rs801871551,2
    --2397648(+) TTTTTC/TCCTTT 2 -- int10--------
    rs113094641,2
    C--2397651(+) TTCCC-/TTTTTT 2 -- int1 trp32Minor allele frequency- T:0.00NA CSA 4
    rs789514121,2
    C--2397651(+) TTCCCC/TTTTTT 2 -- int10--------
    rs1433414711,2
    --2397699(+) TAAAAC/TGGCGA 2 -- int10--------
    rs1114595781,2
    C,F--2397786(+) GTGCAG/ATGGCT 2 -- int11Minor allele frequency- A:0.50WA 2
    rs1861688031,2
    --2397805(+) CCTCTA/GCCTCC 2 -- int10--------
    rs64613321,2
    C,F,A,H--2397907(+) acagaC/Tggggt 2 -- int18Minor allele frequency- T:0.49NA WA CSA EA 368
    rs1902848711,2
    --2398010(+) CACCAC/TGCTGG 2 -- int10--------
    rs1409669911,2
    C--2398108(+) GAGAAC/TAAATA 2 -- int10--------
    rs789792991,2
    C--2398139(+) ATCTG-/CCATAT 2 -- int10--------
    rs113107821,2
    C--2398140(+) ATCTGC/-ATATT 2 -- int13Minor allele frequency- -:0.17NA CSA 6
    rs1181866491,2
    C,F--2398680(+) AAGACC/ACTGTC 2 -- int11Minor allele frequency- A:0.04NA 120
    rs3751345391,2
    C--2398696(+) CAAAG-/AAAAAA 2 -- int10--------
    rs1814280891,2
    --2398754(+) GTGCCA/GGTCTC 2 -- int10--------
    rs1863684581,2
    --2398780(+) TTTCAA/GAAAGG 2 -- int10--------
    rs1908170321,2
    --2398843(+) CACTCA/TGCGTC 2 -- int10--------
    rs132364281,2
    C,F,H--2399008(+) gagttG/Tatcac 2 -- int111Minor allele frequency- T:0.13NS EA NA 666
    rs1502209001,2
    --2399015(+) TCACCA/GGTGCT 2 -- int10--------
    rs102416581,2
    C,F,H--2399097(+) ccatgC/Tagcgg 2 -- int15Minor allele frequency- T:0.02NS EA WA 538
    rs125336991,2
    C,F,H--2399161(+) cgcttG/Ctcctc 2 -- int1 trp313Minor allele frequency- C:0.47NS EA NA WA CSA 768
    rs125337001,2
    C,F,H--2399179(+) cttttC/Tgtcta 2 -- int120Minor allele frequency- T:0.48NS EA NA WA CSA 2346
    rs1457028191,2
    --2399261(+) ATTAAC/TGGAAC 2 -- int10--------
    rs789132461,2
    C,F--2399270(+) ACCCAA/CGAAGC 2 -- int11Minor allele frequency- C:0.06NA 120
    rs1809614901,2
    --2399275(+) AGAAGC/GGAGGG 2 -- int10--------
    rs578864501,2
    C,F--2399290(+) TGGGAG/TCCCTG 2 -- int12Minor allele frequency- T:0.15WA 120
    rs730452031,2
    C,F--2399485(+) GATGCG/CACACC 2 -- int11Minor allele frequency- C:0.02NA 120
    rs732774221,2
    C,F--2399494(+) CCCACG/ATCCGG 2 -- int12Minor allele frequency- A:0.02WA 120
    rs1489417751,2
    C--2399646(+) GTGGGC/TTCTGC 2 -- int10--------
    rs756296661,2
    C,F--2399738(+) TTCACG/AGCCTG 2 -- int11Minor allele frequency- A:0.02EA 120
    rs788355831,2
    F--2399858(+) CAGCAC/TAAATG 2 -- int12Minor allele frequency- T:0.06CSA WA 119
    rs1860354521,2
    --2399975(+) GCAACA/GAACCT 2 -- int10--------
    rs1471090321,2
    C--2399979(+) CAAACC/GTTTCA 2 -- int10--------
    rs1385816811,2
    --2399993(+) TCTAGG/TCATCT 2 -- int10--------
    rs1913634491,2
    --2400134(+) GTTTAC/TATTTC 2 -- int10--------
    rs1998418761,2
    C--2400163(+) GAGTT-/CCAGTC 2 -- int10--------
    rs1441139811,2
    --2400266(+) TTGAAA/GACTTG 2 -- int10--------
    rs9537701,2
    C,F,A,H--2400306(-) TACCAA/GGAAAA 2 -- int129Minor allele frequency- N:0.00EA NA NS WA CSA 4172
    rs2013318951,2
    C--2400372(+) AGATCG/AGCCCC 4 /Q /R mis11Minor allele frequency- A:0.00EU 1323
    rs581743341,2
    C,F--2400394(+) GGAATC/TGATTC 4 I syn14Minor allele frequency- T:0.01NS WA NA EU 6071
    rs2011553101,2
    --2400401(+) ATTCGG/TTGATT 4 V L mis10--------
    rs1434262171,2
    C,F--2400417(+) GGACAA/GTGTCC 4 N S mis12Minor allele frequency- G:0.00NA EU 5875
    rs1471528151,2
    C,F--2400427(+) CCTCAG/CGTGGG 4 /H /Q mis11Minor allele frequency- C:0.00NA 4552
    rs1467094041,2
    C--2400549(+) GTTCTC/TCTGTT 2 -- int10--------
    rs1997132621,2
    --2400552(+) CTCCTA/GTTGGA 2 -- int10--------
    rs616076361,2
    --2400650(+) GGGCCA/GTTCAC 2 -- int10--------
    rs763103471,2
    C,F--2400666(+) CAGGCC/TGCCCT 2 -- int11Minor allele frequency- T:0.04WA 118
    rs790364551,2
    C,F--2400737(+) AGGTTT/GTAAAG 2 -- int12Minor allele frequency- G:0.02CSA WA 120
    rs1411989771,2
    --2400813(+) CCTGAA/GGCCAG 2 -- int10--------
    rs1390117381,2
    C--2400966(+) TGCTGC/TTGCAT 2 -- int10--------
    rs1878161741,2
    --2400980(+) CTGTGC/TTGGGC 2 -- int10--------
    rs1906935291,2
    --2400984(+) GTTGGA/GCAGTC 2 -- int10--------
    rs1829354671,2
    --2401216(+) CGCCCA/GGCTAA 2 -- int10--------
    rs1880024181,2
    --2401235(+) ATTTTC/TAGTAG 2 -- int10--------
    rs126998801,2
    C,F--2401252(+) ggtttT/Caccat 2 -- int15Minor allele frequency- C:0.40NA WA 10
    rs1924920811,2
    --2401279(+) TCGATC/TTCCTG 2 -- int10--------
    rs1845370631,2
    --2401363(+) TGAGCC/TTCTTT 2 -- int10--------
    rs1878835101,2
    --2401414(+) GTTTTG/TTTTGT 2 -- int10--------
    rs1921758151,2
    --2401504(+) CCTCCC/TGGGTT 2 -- int10--------
    rs126998811,2
    C,F--2401569(+) accacG/Acctgg 2 -- int19Minor allele frequency- A:0.14NA WA EA 370
    rs604028251,2
    C--2401612(+) TTATTTATTT   
       ATT
    /-
    GAGAC
    2 -- int11Minor allele frequency- -:0.00NA 2
    rs1849551531,2
    --2401657(+) TGGCAC/GGATCT 2 -- int10--------
    rs790396671,2
    C,F--2401934(+) TGATAT/CACAGT 2 -- int11Minor allele frequency- C:0.09EA 120
    rs774590811,2
    C,F--2401954(+) TAGTTT/GTAAAG 2 -- int12Minor allele frequency- G:0.06CSA WA 120
    rs1459439191,2
    C--2401961(+) AAAGCA/GTACAA 2 -- int10--------
    rs1884445141,2
    --2401966(+) GTACAA/GTTTAA 2 -- int10--------
    rs1399556001,2
    C--2402069(+) AGAGAC/TTTCGG 2 -- int10--------
    rs753087631,2
    F--2402172(+) AGCACA/GGATAC 2 -- int11Minor allele frequency- G:0.01WA 118
    rs1434857491,2
    --2402200(+) TGTCCA/GTGGAG 2 -- int10--------
    rs1816400691,2
    --2402215(+) GTGGGA/GCGGAC 2 -- int10--------
    rs2018523851,2
    --2402234(+) CCTGCC/TTAGCC 2 -- int10--------
    rs1125399061,2
    C--2402239(+) CTAGCA/C/TTTACA 2 -- int11CSA 2
    rs1842893901,2
    --2402266(+) ACGGCC/TCTCTC 2 -- int10--------
    rs2019317171,2
    C,F--2402274(+) CTCTCA/TCTCAG 2 -- int11Minor allele frequency- T:0.00EU 1321
    rs1402881211,2
    C,F--2402298(+) GAGTAC/TGCGTC 4 Y syn11Minor allele frequency- T:0.00NA 4552
    rs1462304011,2
    C--2402313(+) GCCCAC/TGCTGT 4 H syn11Minor allele frequency- T:0.00NA 4552
    rs2009696171,2
    --2402328(+) GCTGTA/GAAGAA 4 V syn10--------
    rs2004892771,2
    --2402341(+) CCGACA/GGCTAC 4 S G mis10--------
    rs1167703641,2
    C,F--2402388(+) TTTACG/AGATTT 4 /T syn12Minor allele frequency- A:0.00WA NA 4668
    rs1818563731,2
    C,F--2402427(+) GGAAGT/CGGACG 2 -- int11Minor allele frequency- C:0.00EU 1323
    rs2020136951,2
    C--2402438(+) TTGACG/ATGCAA 2 -- int11Minor allele frequency- A:0.00EU 1323
    rs1869865161,2
    C--2402459(+) GTGTGC/TGGGTG 2 -- int11Minor allele frequency- T:0.00EU 1277
    rs1910574431,2
    --2402527(+) CTGCCA/GCAGAG 2 -- int10--------
    rs1484668651,2
    C--2402633(+) GGCCAC/TGCTGG 2 -- int10--------
    rs1807356211,2
    C--2402666(+) TAGTCA/GTCAGG 2 -- int10--------
    rs1423447051,2
    C--2402676(+) GGCGTA/GGGGCT 2 -- int10--------
    rs1512821641,2
    C--2402719(+) GATCAG/TTGACG 4 S I mis10--------
    rs1487851841,2
    C,F--2402724(+) GTGACG/AAGTGG 4 /K /E mis11Minor allele frequency- A:0.00NA 4552
    rs2021135911,2
    --2402792(+) CAGTGC/GTTTAA 2 -- int10--------
    rs1404388021,2
    C--2402833(+) CTGCAA/GTCCCA 2 -- int10--------
    rs1866476341,2
    --2402870(+) ATCGCC/TTAAGC 2 -- int10--------
    rs1170420611,2
    F--2402977(+) TATTCC/GCAGCT 2 -- int11Minor allele frequency- G:0.01EA 120
    rs37788951,2
    C,F--2403063(+) TGATTG/ATGCCA 2 -- int111Minor allele frequency- A:0.17NA WA CSA EA 375
    rs795213491,2
    F--2403128(+) TAGACG/AGTGTC 2 -- int13Minor allele frequency- A:0.06CSA WA 121
    rs1901582121,2
    --2403153(+) GGGTGC/TGACTT 2 -- int10--------
    rs1831526081,2
    --2403196(+) CTTTAA/GGAGCA 2 -- int10--------
    rs1453324601,2
    C--2403240(+) GAAATG/TTTATA 2 -- int11Minor allele frequency- T:0.00EU 1299
    rs1498303301,2
    C--2403254(+) TTGTC-/TTTTTGT 2 -- int10--------
    rs1875090871,2
    C,F--2403255(+) TTGTCT/CTTGTT 2 -- int11Minor allele frequency- C:0.01EU 1321
    rs779817091,2
    C--2403288(+) GGCTTG/TAAGAG 4 E * stg10--------
    rs1404905241,2
    C,F--2403371(+) AAAGAC/ACCTGT 4 /E /D mis11Minor allele frequency- A:0.00NA 4548
    rs2011066051,2
    --2403377(+) CCTGTC/GTCAAT 4 V syn10--------
    rs1122842351,2
    C--2403396(+) GAGCGA/C/GTGTGT 2 -- spd11CSA 1
    rs2003987971,2
    C--2403413(+) TGCTGC/TTGGGG 2 -- int10--------
    rs607756581,2
    F--2403693(+) AGATTT/GAGACC 2 -- int11Minor allele frequency- G:0.33CSA 3
    rs1904568941,2
    --2403706(+) CCTGGC/TTAACA 2 -- int10--------
    rs604987421,2
    C,F--2403713(+) AACACA/GGTGAA 2 -- int11Minor allele frequency- G:0.00CSA 1
    rs1840950821,2
    --2403782(+) GTCCCC/TGCTAC 2 -- int10--------
    rs605385941,2
    C,F--2403821(+) GAACCA/TGGGAG 2 -- int11Minor allele frequency- T:0.33CSA 3
    rs1886471831,2
    --2403854(+) ATTGCA/GCCACT 2 -- int10--------
    rs1169409101,2
    F--2403911(+) AAGTTT/AGTAGA 2 -- int11Minor allele frequency- A:0.11NA 120
    rs1995070211,2
    C--2403981(+) GTATTA/GACGTT 2 -- int10--------
    rs2003168691,2
    C--2404001(+) TTTTTC/ATGCAG 2 -- int11Minor allele frequency- A:0.00EU 1321
    rs1388901821,2
    C--2404002(+) TTTTCC/TGCAGA 2 -- int10--------
    rs617426691,2
    C,F--2404135(+) GGGGTT/CCAGCT 4 /V syn13Minor allele frequency- C:0.02NS WA NA 4744
    rs1489881621,2
    --2404257(+) AACTTA/GGTAGA 2 -- int10--------
    rs1434893381,2
    C--2404269(+) AAATAA/CGGGAG 2 -- int10--------
    rs1479980681,2
    --2404331(+) ATTTAC/TGTCAT 2 -- int10--------
    rs1927623361,2
    --2404416(+) GTGTAC/TTCCTA 2 -- int10--------
    rs46091061,2
    C,F,H--2404455(+) GTGTGG/TGTACT 2 -- int120Minor allele frequency- T:0.45NS EA NA WA 2324
    rs765603411,2
    C,F--2404539(+) ATGTTC/TTGTAT 2 -- int11Minor allele frequency- T:0.03NA 120
    rs1842434951,2
    --2404561(+) TCCTTC/TAGTTC 2 -- int10--------
    rs1871557021,2
    --2404572(+) AGGATC/GTAGTC 2 -- int10--------
    rs1424776231,2
    --2404594(+) ATTTTA/GCAGAT 2 -- int10--------
    rs102521121,2
    C,F,A,H--2404657(+) TTGCAG/AGCTCA 2 -- int15Minor allele frequency- A:0.30WA CSA NA EA 362
    rs1916326291,2
    --2404749(+) CATATA/GGCTAA 2 -- int10--------
    rs624441631,2
    F--2404881(+) CACCTG/AGCCGA 2 -- int11Minor allele frequency- A:0.50NA 2
    rs1385312431,2
    --2404889(+) CGAGCC/TGTGAT 2 -- int10--------
    rs125409571,2
    C,F,H--2404912(+) TAATCC/TGGCTG 2 -- int14Minor allele frequency- T:0.02NS EA 390
    rs1508111351,2
    --2404913(+) AATCCA/GGCTGT 2 -- int10--------
    rs78108121,2
    C,F,A,H--2404952(+) GTGGGA/CGGCAG 2 -- int18Minor allele frequency- C:0.21NS NA WA CSA EA 478
    rs1129758341,2
    F--2405020(+) GCGAAC/TGGGGG 2 -- int11Minor allele frequency- T:0.50CSA 2
    rs78109441,2
    C,F,A,H--2405028(+) GGGCCG/ACTCTA 2 -- int114Minor allele frequency- A:0.14NS EA NA WA CSA 779
    rs1844898161,2
    --2405061(+) GCAGTG/TCGAGG 2 -- int10--------
    rs77916791,2
    C,F,A,H--2405127(+) GTGTTA/GTAAGG 2 -- int122Minor allele frequency- G:0.18NS EA NA WA CSA 2341
    rs1889428181,2
    --2405193(+) CAAGCC/GAGCAG 2 -- int10--------
    rs725691391,2
    C,F--2405260(+) TGCTGA/GCTTTC 2 -- int15Minor allele frequency- G:0.38NA CSA EA 245
    rs2003810471,2
    --2405287(+) GTTTT-/TTTG  
            
    TTTGT
    2 -- int10--------
    rs102528371,2
    C,F,A,H--2405290(+) TTTTTT/GTTTGT 2 -- int13Minor allele frequency- G:0.40NA WA CSA 5
    rs673377371,2
    C--2405290(+) TTTTT-/G/GTT 
            
    TGTTT
    4 -- int1 cds10--------
    rs1381376721,2
    C--2405303(+) GTTTG-/TTTGTTT 2 -- int10--------
    rs3727672201,2
    C--2405303(+) GTTTG-/TTTGTT
    TGTTTTGT
    TTTTT
    2 -- int10--------
    rs3682073041,2
    C--2405316(+) GTTTT-/TTTTTT 2 -- int10--------
    rs1814932491,2
    --2405485(+) TTTGTA/GTTTTT 2 -- int10--------
    rs1440565021,2
    C--2405549(+) CTCCGC/GACCTT 2 -- int10--------
    rs1125940361,2
    F--2405656(+) ACATGG/AGTAAA 2 -- int13Minor allele frequency- A:0.05CSA WA 122
    rs730452071,2
    C--2405683(+) GCGCCA/GCCCTC 2 -- int10--------
    rs42839331,2
    H--2405809(+) TTCCGC/ATTGGG 2 -- int14Minor allele frequency- A:0.00NS EA 416
    rs752118731,2
    C,F--2405881(+) GTGTTG/CTGGCC 2 -- int11Minor allele frequency- C:0.50CSA 2
    rs22862041,2
    C,F,O,H--2405885(+) TCTGGA/CCGCAC 2 -- int120Minor allele frequency- C:0.42EA MN NS NA CSA 4976
    rs1476569621,2
    C--2405952(+) TCTAGA/GTACCT 4 R syn10--------
    rs1423774011,2
    C--2405970(+) TTTAGC/TCCCCT 4 S syn10--------
    rs3710060351,2
    C--2405984(+) GGACAC/TGCAGG 4 T M mis10--------
    rs1998149361,2
    C--2406007(+) CCATAA/GTCATC 4 I V mis11Minor allele frequency- G:0.00EU 1323
    rs1449043261,2
    C,F--2406051(+) TTTCAC/TTGTGA 4 H syn12Minor allele frequency- T:0.01NA EU 5875
    rs778116421,2
    C,F--2406506(+) TGTCAC/TGCTCT 2 -- int12Minor allele frequency- T:0.09CSA WA 120
    rs1513347111,2
    --2406518(+) TGTGCA/GCTGCC 2 -- int10--------
    rs1406161481,2
    --2406573(+) GTTAGC/GTGTGT 2 -- int10--------
    rs1116103431,2
    C,F--2406580(+) GTGTTA/TCTGAG 2 -- int12Minor allele frequency- T:0.40CSA 5
    rs1857459561,2
    C--2406695(+) CTTATC/TAGTTT 2 -- int10--------
    rs1382729471,2
    C--2406718(+) TGTTCA/GGGCTG 2 -- int10--------
    rs2020008791,2
    C--2406721(+) TCAGGC/TTGCTT 2 -- int10--------
    rs603827611,2
    C--2406738(+) ATACC-/AAAAAA 2 -- int10--------
    rs736738131,2
    C--2406749(+) AAAAAA/CAAAAA 2 -- int12Minor allele frequency- C:0.23WA 120
    rs1902692921,2
    --2406820(+) CTTGGC/GAGCTT 2 -- int10--------
    rs1810094901,2
    --2406821(+) TTGGGA/TGCTTG 2 -- int10--------
    rs582644421,2
    C,F--2406835(+) TCAGGG/ATGCCT 2 -- int12Minor allele frequency- A:0.04WA 120
    rs750690531,2
    C,F--2406890(+) CCTCGG/TTCCAG 2 -- int11Minor allele frequency- T:0.03WA 118
    rs102606031,2
    C,F,A,H--2406925(+) GGCCTC/GTTCTG 2 -- int115Minor allele frequency- G:0.13NS EA NA WA CSA 787
    rs1995541681,2
    --2407009(+) CGTCA-/CCCCAG 2 -- int10--------
    rs1408601141,2
    C--2407065(+) CCATTA/GCAGTT 2 -- int10--------
    rs1447126041,2
    --2407139(+) AGTCTA/CGCTCC 2 -- int10--------
    rs1858887971,2
    --2407145(+) GCTCCA/GTCAGG 2 -- int10--------
    rs1385273861,2
    --2407167(+) TGATAC/TGATCT 2 -- int10--------
    rs1415629801,2
    --2407223(+) CCTCAA/GCCTCC 2 -- int10--------
    rs1445948511,2
    --2407270(+) CGGCTA/GATTTT 2 -- int10--------
    rs1480517741,2
    C--2407390(+) GAGCCA/TCCATG 2 -- int10--------
    rs102356521,2
    C,A,H--2407415(+) CAGTTC/TTTAAC 2 -- int14Minor allele frequency- T:0.00NS EA 412
    rs1888626981,2
    --2407436(+) GAAAAC/TGGTGA 2 -- int10--------
    rs1417998441,2
    --2407437(+) AAAACA/GGTGAG 2 -- int10--------
    rs1505500351,2
    --2407439(+) AACGGG/TGAGTT 2 -- int10--------
    rs779955251,2
    C--2407449(+) TTGTTC/TTTTTT 2 -- int10--------
    rs1812886061,2
    --2407527(+) GCTGGC/TGTAGA 2 -- int10--------
    rs1128226611,2
    C,F--2407594(+) TGCCTC/TAGACT 2 -- int11Minor allele frequency- T:0.00CSA 1
    rs1855493261,2
    C--2407665(+) TAGAGA/TTGGGG 2 -- int10--------
    rs1439120871,2
    --2407689(+) GCCATC/GCTGGT 2 -- int10--------
    rs1907025671,2
    C--2407766(+) GAGCCA/CCCACA 2 -- int10--------
    rs1162227751,2
    F--2407853(+) GCTGAC/TTGCAG 2 -- int11Minor allele frequency- T:0.05WA 118
    rs1114162001,2
    F--2408050(+) AAAGTG/TCAGGG 2 -- int11Minor allele frequency- T:0.50CSA 2
    rs1457198331,2
    --2408151(+) CAGCAC/TTGGGC 2 -- int10--------
    rs1485732151,2
    --2408168(+) CCCTTA/GAGGCA 2 -- int10--------
    rs1429788291,2
    --2408206(+) AGAAAA/TGAATT 2 -- int10--------
    rs1123112721,2
    C--2408214(+) ATTTTC/TAAGGC 2 -- int12Minor allele frequency- T:0.06CSA WA 119
    rs1833249641,2
    --2408420(+) TATCGA/CAAAAC 2 -- int10--------
    rs37350941,2
    C,F,H--2408435(+) GACTGG/ATCAGT 2 -- int15Minor allele frequency- A:0.00EA NS 1912
    rs14197211,2
    C,F,A,H--2408479(+) ATTGAC/TGTTTC 2 -- int18Minor allele frequency- T:0.01MN NS EA NA WA 702
    rs1510865671,2
    --2408511(+) GGGCAA/GAATTA 2 -- int10--------
    rs754714831,2
    F--2408538(+) AAGACC/GAGGAC 2 -- int11Minor allele frequency- G:0.02NA 120
    rs1413757871,2
    --2408618(+) GAGCCA/GTTCGT 2 -- int10--------
    rs1145207451,2
    F--2408624(+) TTCGTT/CACAGC 2 -- int11Minor allele frequency- C:0.03WA 118
    rs1446537111,2
    --2408685(+) GCTCAA/TTCCTT 2 -- int10--------
    rs1919222721,2
    --2408788(+) AGCAGC/GAGTGT 2 -- int10--------
    rs736738141,2
    C,F--2408817(+) GCTGAC/TGGAGC 2 -- int14Minor allele frequency- T:0.24WA CSA 124
    rs1467060091,2
    C--2408948(+) CTGCGC/TGGCAT 2 -- int10--------
    rs1830206101,2
    --2408956(+) CATGCC/GCAGAG 2 -- int10--------
    rs1866337721,2
    --2408986(+) GCGCTC/TAGCGT 2 -- int10--------
    rs1154496321,2
    F--2408990(+) TCAGCG/CTCAGC 2 -- int11Minor allele frequency- C:0.01WA 118
    rs1125804981,2