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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

EIF3B Gene

protein-coding   GIFtS: 57
GCID: GC07P002362

eukaryotic translation initiation factor 3, subunit B

(Previous names: eukaryotic translation initiation factor 3, subunit 9 eta,...)
(Previous symbol: EIF3S9)
 Explore 4 diseases affiliated with
EIF3B via our new
 Human Malady Compendium 
Biological research products
for EIF3B
    

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section

Aliases
Eukaryotic Translation Initiation Factor 3, Subunit B1 2     EIF3 P1102 3
EIF3S91 2 3 5     EIF3 P1162 3
PRT11 2 5     HPrt11
Eukaryotic Translation Initiation Factor 3, Subunit 9 Eta, 116kDa1 2     EIF3-ETA2
EIF3b1     EIF3-P1102
Eukaryotic Translation Initiation Factor 3 Subunit 92 3     EIF3-P1162
Prt1 Homolog2 3     Eukaryotic Translation Initiation Factor 3 Subunit B2
EIF-3-Eta1     Eukaryotic Translation Initiation Factor 3, Subunit 9 (Eta, 116kD)2

External Ids:    HGNC: 32801   Entrez Gene: 86622   Ensembl: ENSG000001062637   OMIM: 6039175   UniProtKB: P558843   

Export aliases for EIF3B gene to outside databases


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

UniProtKB/Swiss-Prot: EIF3B_HUMAN, P55884
Function: Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several
steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and facilitates the
recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S preinitiation complex (43S PIC). The
eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3
complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently
prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation

Gene Wiki entry for EIF3B


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000007.13  NC_018918.1  NT_007819.17  NT_079592.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the EIF3B gene promoter:
         Max1   Pax-5   NF-E2 p45   Egr-4   AREB6   Pax-4a   NF-E2   ATF   ATF6   c-Myc   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 11): EIF3B promoter sequence
   Search SABiosciences Chromatin IP Primers for EIF3B

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat EIF3B


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 7p22.3   Ensembl cytogenetic band:  7p22.3   HGNC cytogenetic band: 7p22

EIF3B Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
EIF3B gene location

GeneLoc information about chromosome 7         GeneLoc Exon Structure

GeneLoc location for GC07P002362:  view genomic region     (about GC identifiers)

Start:
2,393,721 bp from pter      End:
2,420,380 bp from pter
Size:
26,660 bases      Orientation:
plus strand

1 alternative location:
Chr7+,CRA_TCAG 2,442,541-2,468,274     

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: EIF3B_HUMAN, P55884 (See protein sequence)
Recommended Name: Eukaryotic translation initiation factor 3 subunit B  
Size: 814 amino acids; 92482 Da
Subunit: Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is composed of 13 subunits:
EIF3A, EIF3B, EIF3C, EIF3D, EIF3E, EIF3F, EIF3G, EIF3H, EIF3I, EIF3J, EIF3K, EIF3L and EIF3M. The eIF-3 complex
appears to include 3 stable modules: module A is composed of EIF3A, EIF3B, EIF3G and EIF3I; module B is composed of
EIF3F, EIF3H, and EIF3M; and module C is composed of EIF3C, EIF3D, EIF3E, EIF3K and EIF3L. EIF3C of module C binds
EIF3B of module A and EIF3H of module B, thereby linking the three modules. EIF3J is a labile subunit that binds to
the eIF-3 complex via EIF3B. The eIF-3 complex interacts with RPS6KB1 under conditions of nutrient depletion.
Mitogenic stimulation leads to binding and activation of a complex composed of MTOR and RPTOR, leading to
phosphorylation and release of RPS6KB1 and binding of EIF4B to eIF-3. Also interacts with UPF2
Subcellular location: Cytoplasm (By similarity)
Mass spectrometry: Mass=93093.7; Method=Unknown; Range=1-814; Source=PubMed:17322308;
Mass spectrometry: Mass=92561; Mass_error=43.5; Method=MALDI; Range=1-814; Source=PubMed:18599441;
2 PDB 3D structures from and Proteopedia for EIF3B:
2KRB (3D)        2NLW (3D)    
Secondary accessions: A4D208 Q2NL77 Q9UMF9
Alternative splicing: 2 isoforms:  P55884-1   P55884-2   

Explore the universe of human proteins at neXtProt for EIF3B: NX_P55884

Post-translational modifications:

  • Phosphorylated. Phosphorylation is enhanced upon serum stimulation1
  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_P55884

  • EIF3B Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins (2 alternative transcripts): 
    NP_001032360.1  NP_003742.2  

    ENSEMBL proteins: 
     ENSP00000408062   ENSP00000354125   ENSP00000407785   ENSP00000380206  
    Reactome Protein details: P55884
    Human Recombinant Protein Products: 
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    Uscn Proteins for EIF3B

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005829cytosol TAS--
    GO:0005852eukaryotic translation initiation factor 3 complex IDA17581632


    EIF3B for ontologies           About GeneDecksing



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    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    EIF3B for domains           About GeneDecksing

    5 InterPro domains/families:
     IPR013979 TIF2A_beta_prop-like
     IPR000504 RRM_dom
     IPR012677 Nucleotide-bd_a/b_plait
     IPR015943 WD40/YVTN_repeat-like_dom
     IPR011400 eIF3b

    Graphical View of Domain Structure for InterPro Entry P55884

    ProtoNet protein and cluster: P55884

    2 Blocks protein families:
    IPB000504 RNA-binding region RNP-1 (RNA recognition motif)
    IPB013979 Eukaryotic translation initiation factor 2A


    UniProtKB/Swiss-Prot: EIF3B_HUMAN, P55884
    Domain: The RRM domain mediates interaction with EIF3J
    Similarity: Belongs to the eIF-3 subunit B family
    Similarity: Contains 1 RRM (RNA recognition motif) domain
    Similarity: Contains 5 WD repeats


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section

    Function Summary:

         UniProtKB/Swiss-Prot: EIF3B_HUMAN, P55884
    Function: Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several
    steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and facilitates the
    recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S preinitiation complex (43S PIC). The
    eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3
    complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently
    prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation

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    Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000166nucleotide binding IEA--
    GO:0003743contributes to translation initiation factor activity IDA17581632
    GO:0005515protein binding IPI18628297
    GO:0032947protein complex scaffold TAS17322308


    EIF3B for ontologies           About GeneDecksing


    5 GenomeRNAi human phenotypes for EIF3B:
     Decreased G3BP1 protein expres  Decreased viability of wild-ty  Increased cell death in HCT116  Nuclear 60S biogenesis defects 
     Nucleolar pre-40S maturation d 


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways - 5/7 super-pathways (see all 7About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Synthesis of PB1-F2
    Formation of a pool of free 40S subunits0.87
    Eukaryotic Translation Initiation0.73
    L13a-mediated translational silencing of Ceruloplasmin expression0.79
    Cap-dependent Translation Initiation0.73
    3' -UTR-mediated translational regulation0.79
    Translation0.57
    GTP hydrolysis and joining of the 60S ribosomal subunit0.78
    2Translation initiation complex formation
    Translation initiation complex formation1.00
    Ribosomal scanning and start codon recognition0.96
    Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S0.98
    Formation of the ternary complex, and subsequently, the 43S complex0.87
    3IL-2 Signaling Pathway
    IL-2 Signaling Pathway1.00
    4Translation Factors
    Translation Factors1.00
    5RNA transport
    RNA transport1.00

    Pathway sources
    See GeneCards unified pathways
    Show all pathways


    2 BioSystems Pathways for EIF3B 
        Translation Factors
    IL-2 Signaling Pathway

    5/13        Reactome Pathways for EIF3B (see all 13)
        Formation of the ternary complex, and subsequently, the 43S complex
    Translation
    GTP hydrolysis and joining of the 60S ribosomal subunit
    Eukaryotic Translation Initiation
    Ribosomal scanning and start codon recognition


    1         Kegg Pathway  (Kegg details for EIF3B):
        RNA transport


    EIF3B for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for EIF3B

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/735 Interacting proteins for EIF3B (P558841, 2, 3 ENSP000003541254) via UniProtKB, MINT, STRING, and/or I2D (see all 735)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    HIST1H4AP628053I2D: score=1 
    HIST1H4BP628053I2D: score=1 
    HIST1H4CP628053I2D: score=1 
    HIST1H4DP628053I2D: score=1 
    HIST1H4EP628053I2D: score=1 
    About this table

    Gene Ontology (GO): 5 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006412translation TAS--
    GO:0006413translational initiation TAS--
    GO:0006446regulation of translational initiation IDA8995410
    GO:0010467gene expression TAS--
    GO:0044267cellular protein metabolic process TAS--


    EIF3B for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for EIF3B
    Search CenterWatch for drugs/clinical trials and news about EIF3B 

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
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    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for EIF3B gene (2 alternative transcripts): 
    NM_001037283.1  NM_003751.3  

    Unigene Cluster for EIF3B:

    Eukaryotic translation initiation factor 3, subunit B
    Hs.371001  [show with all ESTs]
    Unigene Representative Sequence: AB209381
    12 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000431643 ENST00000360876(uc003slx.3 uc003sly.3 uc003slz.1)
    ENST00000413917 ENST00000397011(uc003sma.3) ENST00000463229 ENST00000463026
    ENST00000468250 ENST00000466199 ENST00000475415 ENST00000468611(uc003smb.3)
    ENST00000465670 ENST00000494658

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    Additional cDNA sequence: 

    AB209381.1 AK127885.1 AK300967.1 AK302058.1 BC001173.1 BC009986.1 BC110865.1 U62583.1 
    U78525.1 

    24/35 DOTS entries (see all 35):

    DT.100834695  DT.97798019  DT.100759692  DT.95173385  DT.100834690  DT.454061  DT.100730058  DT.429116 
    DT.92462641  DT.97786597  DT.203336  DT.70104982  DT.102836765  DT.100039603  DT.95305235  DT.95148198 
    DT.97864515  DT.121124337  DT.95313948  DT.100834693  DT.121124353  DT.100033517  DT.100834684  DT.100834692 

    24/758 AceView cDNA sequences (see all 758):

    AW613698 BQ221471 BM560380 BF108826 BQ709516 AW015861 AI825123 CB115033 
    AI204368 BC001173 BQ669015 CA434118 BP368238 BU175745 CD673946 BU856686 
    AI699769 CR603939 AI336324 BQ643260 AU124102 AW473838 BM904776 BU956074 

    GeneLoc Exon Structure

    5/18 Alternative Splicing Database (ASD) splice patterns (SP) for EIF3B (see all 18)    About this scheme

    ExUns: 1 ^ 2 ^ 3a · 3b · 3c ^ 4a · 4b ^ 5a · 5b ^ 6a · 6b ^ 7a · 7b ^ 8a · 8b ^ 9a · 9b · 9c ^ 10 ^ 11a · 11b ^ 12a · 12b ^ 13 ^ 14 ^ 15a ·
    SP1:                                                                                            -                             -           -     -               
    SP2:                                                                                            -                             -           -     -               
    SP3:                                                                                            -                             -           -     -               
    SP4:                                                                                            -                             -           -     -               
    SP5:        -     -     -     -                                                                                                                                 

    ExUns: 15b · 15c ^ 16 ^ 17a · 17b ^ 18 ^ 19a · 19b · 19c ^ 20a · 20b ^ 21 ^ 22a · 22b ^ 23a · 23b ^ 24a · 24b · 24c
    SP1:        -           -                 -                                         -     -           -               
    SP2:        -           -                 -                                         -                                 
    SP3:        -           -                 -                                         -     -                           
    SP4:        -           -                 -                                         -     -                           
    SP5:                                                                                                                  


    ECgene alternative splicing isoforms for EIF3B

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    EIF3B expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: GAAATAAAAG

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)

    About this image
    See EIF3B Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for EIF3B

    SOURCE GeneReport for Unigene cluster: Hs.371001
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    Products:
    OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for EIF3B
    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat EIF3B
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat EIF3B
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat EIF3B
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for EIF3B

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of eukaryotes.

    Orthologs for EIF3B gene from 9/36 species (see all 36)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    chicken
    (Gallus gallus)
    Aves EIF3B1 eukaryotic translation initiation factor 3, subunit more 79.62(n)
    91.02(a)
      769783  XM_003642142.1  XP_003642190.1 
    lizard
    (Anolis carolinensis)
    Reptilia --
    --
    81(a)
    1 ↔ 1
    GL343340.1(42357-51899)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.260732 Xenopus laevis transcribed sequence with moderate similarity more 77.37(n)    48055327 
    zebrafish
    (Danio rerio)
    Actinopterygii wufc17c012 wufc17c01 82.82(n)   324028  CA787533.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta eIF3-S91 CG4878-PA 58.47(n)
    53.76(a)
      36981  NM_137384.3  NP_611228.1 
    worm
    (Caenorhabditis elegans)
    Secernentea eif-3.B1 Protein EIF-3.B 46.13(n)
    36.6(a)
      175138  NM_001027298.3  NP_001022469.1 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes PRT1(YOR361C)4
    PRT11
    eIF3b subunit of the core complex of translation initiation more4
    Prt1p1
    47.92(n)1
    34.28(a)1
      15(1017652-1015361)4
    8545431, 4  NP_015006.31  NP_015006.14 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons TIF3B11 translation initiation factor 3 subunit B 53.14(n)
    43.23(a)
      832826  NM_001036877.2  NP_001031954.1 
    rice
    (Oryza sativa)
    Liliopsida Os.48992 Oryza sativa (japonica cultivar-group) cDNA clone0 more 70.36(n)    AK110143.1 


    ENSEMBL Gene Tree for EIF3B (if available)
    TreeFam Gene Tree for EIF3B (if available) 

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    703/761 NCBI SNPs in EIF3B are shown (see all 761    About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 7 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs77959371,2
    C,--2392502(+) cttatC/Tgtaca 2 -- us2k10--------
    rs1866445271,2
    --2392544(+) ACCTGC/TCCAAA 2 -- us2k10--------
    rs1911089171,2
    --2392571(+) CATGAC/TGAGGA 2 -- us2k10--------
    rs1405732621,2
    --2392678(+) AGTCCC/TGGCAC 2 -- us2k10--------
    rs749343721,2
    F,--2392748(+) ACACAG/ATGAGA 2 -- us2k11Minor allele frequency- A:0.03NA 120
    rs1457357701,2
    --2392785(+) TGGGCA/GCGGTG 2 -- us2k10--------
    rs624441621,2
    C,--2392860(+) GCATAT/CTAAAA 2 -- us2k12Minor allele frequency- C:0.08NA 122
    rs1825669971,2
    --2392876(+) AGGCCC/GTGCGC 2 -- us2k10--------
    rs1418556821,2
    --2392881(+) CTGCGC/GGGTGG 2 -- us2k10--------
    rs77929341,2
    C,F,--2393016(+) ACCCTG/ATCTCT 2 -- us2k112Minor allele frequency- A:0.24NA WA CSA EA 374
    rs1129462811,2
    C,--2393037(+) AAAAC-/AAAAAA 2 -- us2k11Minor allele frequency- A:0.50CSA 2
    rs1178406401,2
    F,--2393209(+) ACCGCG/ACAGGG 2 -- us2k11Minor allele frequency- A:0.05EA 120
    rs1881381801,2
    --2393309(+) ACGTTC/TTCATC 2 -- us2k10--------
    rs69445841,2
    C,F,--2393381(+) ACCACT/CTGTTT 2 -- us2k1 tfbs310Minor allele frequency- C:0.32NA WA CSA EA 371
    rs1506893421,2
    --2393472(+) ACTCCA/TAAGCT 2 -- us2k10--------
    rs1135221991,2
    --2393533(+) ATCCAC/TTGGGT 2 -- us2k12Minor allele frequency- T:0.05CSA WA 120
    rs1389276201,2
    --2393586(+) CCTCCA/TCTCCG 2 -- us2k10--------
    rs1128286271,2
    --2393631(+) GCCCGT/CCCCGT 2 -- us2k12Minor allele frequency- C:0.04CSA WA 119
    rs23986611,2
    C,F,A,H,--2393632(-) CACGGT/GACGGG 2 -- us2k113Minor allele frequency- G:0.43NA EA NS WA CSA 668
    rs1929515121,2
    --2393662(+) CCGCTC/GCGGTC 2 -- us2k10--------
    rs783703581,2
    F,--2393773(+) AACCAC/GTGTGA 2 -- us2k11Minor allele frequency- G:0.05WA 118
    rs1851870671,2
    --2393782(+) GAAAGC/GCCGAA 2 -- us2k10--------
    rs1494375931,2
    --2393809(+) GTGACA/GGCCGC 2 -- us2k10--------
    rs1905124911,2
    --2393863(+) TTTTTC/GTATCG 2 -- us2k10--------
    rs78018171,2
    C,F,A,H,--2393947(+) GTCTGG/TCCTTT 2 -- us2k123Minor allele frequency- T:0.33NS EA NA WA CSA 2345
    rs1932424941,2
    --2393951(+) GTCCTC/TTTGCT 2 -- us2k10--------
    rs1447598071,2
    --2393979(+) CAAGTA/GACAGA 2 -- us2k10--------
    rs1400895071,2
    --2394041(+) AGGCTC/GAGACG 2 -- us2k10--------
    rs1147494011,2
    F,--2394051(+) GCCCTG/CAGCAA 2 -- us2k11Minor allele frequency- C:0.03WA 118
    rs1451195341,2
    --2394093(+) TTAACA/TGTTGA 2 -- us2k10--------
    rs1471783441,2
    --2394112(+) ACATTC/TTCCTA 2 -- us2k10--------
    rs1402729111,2
    --2394199(+) GACGGG/TAAAGG 2 -- us2k10--------
    rs1839569411,2
    --2394210(+) AAAGGA/GGGAGG 2 -- us2k10--------
    rs791984581,2
    --2394263(+) GTCAAT/AGCTCC 2 -- us2k11Minor allele frequency- A:0.01EA 120
    rs1882945121,2
    --2394275(+) ATGAGC/TTTACT 2 -- us2k10--------
    rs1420794581,2
    --2394284(+) CTGATA/GCACAG 2 -- us2k10--------
    rs23019421,2
    C,F,A,H,--2394296(+) AACAAC/TCTTGC 2 -- us2k19Minor allele frequency- T:0.45MN NA CSA WA EA 730
    rs1806979701,2
    --2394314(+) AATTAA/TGCACT 2 -- us2k10--------
    rs23019431,2
    C,F,--2394316(+) TTAAGC/GACTTT 2 -- us2k18Minor allele frequency- G:0.21NA WA EA 368
    rs774775471,2
    C,--2394332(+) CACAAA/TTATAT 2 -- us2k10--------
    rs1391850981,2
    --2394345(+) GTTTGA/GTGATT 2 -- us2k10--------
    rs1122943251,2
    C,--2394428(+) GCCCC-/GCGGCGGC 2 -- us2k11Minor allele frequency- GCG:0.50CSA 2
    rs119752051,2
    C,A,H--2394480(+) AGCCGA/TCGCGG 2 -- ut510--------
    rs96907871,2
    C,F,A,H,--2394746(+) CGGAGC/TCCGAG 4 P S mis17Minor allele frequency- T:0.30NA WA CSA 131
    rs1857627941,2
    C,--2394934(+) TCCGAC/GGACGC 4 D E mis10--------
    rs115511671,2
    C,F,--2394991(+) GAGAAC/TGGCGA 4 N syn17Minor allele frequency- T:0.21NA WA EA 366
    rs786807931,2
    C,--2395043(+) ACGACG/CTGAGC 4 /L /V mis11Minor allele frequency- C:0.02EU 107
    rs1897318931,2
    --2395095(+) CGGGAG/TCGTGG 2 -- int10--------
    rs1159009001,2
    C,--2395105(+) GCTGGA/GGTTCC 2 -- int10--------
    rs1818611181,2
    --2395297(+) AGCCAA/GGCATT 2 -- int10--------
    rs1869307401,2
    --2395440(+) CGTGTC/TCCCAG 2 -- int10--------
    rs1456803171,2
    --2395468(+) TCCCAA/GGGTCT 2 -- int10--------
    rs38074301,2
    C,F,A,H,--2395509(+) GTGATT/CTTGTC 2 -- int119Minor allele frequency- C:0.41NS EA NA CSA WA 2342
    rs1465881991,2
    --2395523(+) CTGCCC/TCTCAG 2 -- int10--------
    rs1145840471,2
    F,--2395535(+) ATTGTC/TCATCT 2 -- int11Minor allele frequency- T:0.03WA 118
    rs1921278981,2
    --2395537(+) TGTCCA/GTCTCC 2 -- int10--------
    rs1832479701,2
    --2395594(+) TTTTTC/TTTTAT 2 -- int10--------
    rs1861054291,2
    --2395600(+) TTTATC/TTCTTG 2 -- int10--------
    rs2021686061,2
    --2395615(+) AAATC-/TATAAAG 2 -- int10--------
    rs1491696201,2
    --2395634(+) TTTTTC/TCAGGT 2 -- int10--------
    rs1897801201,2
    --2395702(+) AGGCAA/TATTTT 2 -- int10--------
    rs762140451,2
    --2395724(+) TCAGAG/TATTTT 2 -- int10--------
    rs1482989901,2
    --2395789(+) TAGCTC/GTCTTA 2 -- int10--------
    rs730433001,2
    C,F,--2395884(+) GTAGCC/TAGCGA 2 -- int11Minor allele frequency- T:0.02NA 120
    rs1116362321,2
    C,--2395986(+) CTCACG/ACCTGT 2 -- int11Minor allele frequency- A:0.50WA 2
    rs2001753721,2
    --2396019(+) GAGAC-/GGGTGG 2 -- int10--------
    rs1821172811,2
    --2396020(+) AGACGA/GGTGGA 2 -- int10--------
    rs1154104461,2
    F,--2396042(+) CCATCC/TTGGCT 2 -- int11Minor allele frequency- T:0.03WA 118
    rs1471241461,2
    --2396054(+) ACACGA/GTGAAA 2 -- int10--------
    rs1384731111,2
    --2396093(+) TTAGCC/TGGGCG 2 -- int10--------
    rs1881010051,2
    --2396176(+) GAGCTC/TGCAGT 2 -- int10--------
    rs1928770321,2
    --2396200(+) GCCACA/TGCACT 2 -- int10--------
    rs113957281,2
    C--2396238(+) AAAAAA/-AAAAA 2 -- int1 trp31Minor allele frequency- -:0.00NA 2
    rs1471620481,2
    --2396255(+) AAAAGA/GAAAAG 2 -- int10--------
    rs1835873361,2
    --2396311(+) ACACCC/TGTAGT 2 -- int10--------
    rs1886396301,2
    --2396457(+) AACGCC/TGTCAG 2 -- int10--------
    rs1394973801,2
    --2396472(+) TGTGAC/TCATTA 2 -- int10--------
    rs1160046331,2
    F,--2396485(+) ATATTA/TCACTT 2 -- int11Minor allele frequency- T:0.04WA 118
    rs1492770241,2
    --2396535(+) AGGACA/TCCACA 2 -- int10--------
    rs69524331,2
    C,F,A,H,--2396638(+) GGTCTG/ATACTG 2 -- int124Minor allele frequency- A:0.23NS EA NA WA CSA 1285
    rs1444210471,2
    --2396702(+) TGTTAC/TTATGG 2 -- int10--------
    rs1919573061,2
    --2396727(+) CTTTTC/GGTTTA 2 -- int10--------
    rs1849472381,2
    --2396862(+) TATGAC/TGACAG 2 -- int10--------
    rs1484137581,2
    --2396887(+) GGTGAC/TGGCTG 2 -- int10--------
    rs1426888331,2
    --2396931(+) TGCAGG/TGTTGG 2 -- int10--------
    rs791313871,2
    F,--2397078(+) CGTAGG/CTGACT 2 -- int11Minor allele frequency- C:0.05WA 118
    rs1893253041,2
    --2397109(+) GGCCAA/CGTCTT 2 -- int10--------
    rs1915118461,2
    --2397205(+) TCCTTA/TCAGTT 2 -- int10--------
    rs1465261961,2
    --2397388(+) CAAGGC/TGTTGT 2 -- int10--------
    rs1837011921,2
    --2397520(+) GCAGCC/TTTATA 2 -- int10--------
    rs1897572891,2
    --2397546(+) TGTCAA/GGCTAT 2 -- int10--------
    rs1813390521,2
    --2397557(+) TTAATC/TGTATG 2 -- int10--------
    rs1399111231,2
    --2397569(+) TAAGTA/GCTTTA 2 -- int10--------
    rs1137001221,2
    --2397626(+) ACTGCA/GGTGAC 2 -- int12Minor allele frequency- G:0.04CSA WA 120
    rs801871551,2
    --2397648(+) TTTTTC/TCCTTT 2 -- int10--------
    rs113094641,2
    C,--2397651(+) TTCCC-/TTTTTT 2 -- int1 trp32Minor allele frequency- T:0.00NA CSA 4
    rs789514121,2
    C,--2397651(+) TTCCCC/TTTTTT 2 -- int10--------
    rs1433414711,2
    --2397699(+) TAAAAC/TGGCGA 2 -- int10--------
    rs1114595781,2
    C,--2397786(+) GTGCAG/ATGGCT 2 -- int11Minor allele frequency- A:0.50WA 2
    rs1861688031,2
    --2397805(+) CCTCTA/GCCTCC 2 -- int10--------
    rs64613321,2
    C,F,A,H,--2397907(+) ACAGAC/TGGGGT 2 -- int18Minor allele frequency- T:0.49NA WA CSA EA 368
    rs1902848711,2
    --2398010(+) CACCAC/TGCTGG 2 -- int10--------
    rs1409669911,2
    --2398108(+) GAGAAC/TAAATA 2 -- int10--------
    rs789792991,2
    C,--2398139(+) ATCTG-/CCATAT 2 -- int10--------
    rs113107821,2
    C,--2398140(+) ATCTGC/-ATATT 2 -- int13Minor allele frequency- -:0.17NA CSA 6
    rs1181866491,2
    F,--2398680(+) AAGACC/ACTGTC 2 -- int11Minor allele frequency- A:0.04NA 120
    rs1814280891,2
    --2398754(+) GTGCCA/GGTCTC 2 -- int10--------
    rs1863684581,2
    --2398780(+) TTTCAA/GAAAGG 2 -- int10--------
    rs1908170321,2
    --2398843(+) CACTCA/TGCGTC 2 -- int10--------
    rs132364281,2
    C,F,H,--2399008(+) GAGTTG/TATCAC 2 -- int111Minor allele frequency- T:0.13NS EA NA 666
    rs1502209001,2
    --2399015(+) TCACCA/GGTGCT 2 -- int10--------
    rs102416581,2
    C,F,H,--2399097(+) ccatgC/Tagcgg 2 -- int15Minor allele frequency- T:0.02NS EA WA 538
    rs125336991,2
    C,F,H,--2399161(+) CGCTTG/CTCCTC 2 -- int1 trp313Minor allele frequency- C:0.47NS EA NA WA CSA 768
    rs125337001,2
    C,F,H,--2399179(+) CTTTTC/TGTCTA 2 -- int120Minor allele frequency- T:0.48NS EA NA WA CSA 2346
    rs1457028191,2
    --2399261(+) ATTAAC/TGGAAC 2 -- int10--------
    rs789132461,2
    C,F,--2399270(+) ACCCAA/CGAAGC 2 -- int11Minor allele frequency- C:0.06NA 120
    rs1809614901,2
    --2399275(+) AGAAGC/GGAGGG 2 -- int10--------
    rs578864501,2
    C,--2399290(+) TGGGAG/TCCCTG 2 -- int12Minor allele frequency- T:0.15WA 120
    rs730452031,2
    C,F,--2399485(+) GATGCG/CACACC 2 -- int11Minor allele frequency- C:0.02NA 120
    rs732774221,2
    C,--2399494(+) CCCACG/ATCCGG 2 -- int12Minor allele frequency- A:0.02WA 120
    rs1489417751,2
    --2399646(+) GTGGGC/TTCTGC 2 -- int10--------
    rs756296661,2
    F,--2399738(+) TTCACG/AGCCTG 2 -- int11Minor allele frequency- A:0.02EA 120
    rs788355831,2
    --2399858(+) CAGCAC/TAAATG 2 -- int12Minor allele frequency- T:0.06CSA WA 119
    rs1860354521,2
    --2399975(+) GCAACA/GAACCT 2 -- int10--------
    rs1471090321,2
    --2399979(+) CAAACC/GTTTCA 2 -- int10--------
    rs1385816811,2
    --2399993(+) TCTAGG/TCATCT 2 -- int10--------
    rs1913634491,2
    --2400134(+) GTTTAC/TATTTC 2 -- int10--------
    rs1998418761,2
    --2400163(+) GAGTT-/CCAGTC 2 -- int10--------
    rs1441139811,2
    --2400266(+) TTGAAA/GACTTG 2 -- int10--------
    rs9537701,2
    C,F,A,H,--2400306(-) TACCAA/GGAAAA 2 -- int129Minor allele frequency- N:0.00EA NA NS WA CSA 4172
    rs581743341,2
    C,F,--2400394(+) GGAATC/TGATTC 4 I syn14Minor allele frequency- T:0.01NS WA NA EU 6071
    rs2011553101,2
    --2400401(+) ATTCGG/TTGATT 4 V L mis10--------
    rs1434262171,2
    C,F,--2400417(+) GGACAA/GTGTCC 4 N S mis12Minor allele frequency- G:0.00NA EU 5875
    rs1471528151,2
    C,F,--2400427(+) CCTCAG/CGTGGG 4 /H /Q mis11Minor allele frequency- C:0.00NA 4552
    rs1467094041,2
    C,--2400549(+) GTTCTC/TCTGTT 2 -- int10--------
    rs1997132621,2
    --2400552(+) CTCCTA/GTTGGA 2 -- int10--------
    rs616076361,2
    --2400650(+) GGGCCA/GTTCAC 2 -- int10--------
    rs763103471,2
    C,F,--2400666(+) CAGGCC/TGCCCT 2 -- int11Minor allele frequency- T:0.04WA 118
    rs790364551,2
    --2400737(+) AGGTTT/GTAAAG 2 -- int12Minor allele frequency- G:0.02CSA WA 120
    rs1411989771,2
    --2400813(+) CCTGAA/GGCCAG 2 -- int10--------
    rs1390117381,2
    --2400966(+) TGCTGC/TTGCAT 2 -- int10--------
    rs1878161741,2
    --2400980(+) CTGTGC/TTGGGC 2 -- int10--------
    rs1906935291,2
    --2400984(+) GTTGGA/GCAGTC 2 -- int10--------
    rs1829354671,2
    --2401216(+) CGCCCA/GGCTAA 2 -- int10--------
    rs1880024181,2
    --2401235(+) ATTTTC/TAGTAG 2 -- int10--------
    rs126998801,2
    C,F,--2401252(+) GGTTTT/CACCAT 2 -- int15Minor allele frequency- C:0.40NA WA 10
    rs1924920811,2
    --2401279(+) TCGATC/TTCCTG 2 -- int10--------
    rs1845370631,2
    --2401363(+) TGAGCC/TTCTTT 2 -- int10--------
    rs1878835101,2
    --2401414(+) GTTTTG/TTTTGT 2 -- int10--------
    rs1921758151,2
    --2401504(+) CCTCCC/TGGGTT 2 -- int10--------
    rs126998811,2
    C,F,--2401569(+) ACCACG/ACCTGG 2 -- int19Minor allele frequency- A:0.14NA WA EA 370
    rs1485735711,2
    --2401587(+) CTTGC-/TTA   
       TTTAT
    TTATT
    2 -- int10--------
    rs604028251,2
    C--2401612(+) TTATTTATTT   
       ATT
    /-
    GAGAC
    2 -- int11Minor allele frequency- -:0.00NA 2
    rs1849551531,2
    --2401657(+) TGGCAC/GGATCT 2 -- int10--------
    rs790396671,2
    F,--2401934(+) TGATAT/CACAGT 2 -- int11Minor allele frequency- C:0.09EA 120
    rs774590811,2
    --2401954(+) TAGTTT/GTAAAG 2 -- int12Minor allele frequency- G:0.06CSA WA 120
    rs1459439191,2
    --2401961(+) AAAGCA/GTACAA 2 -- int10--------
    rs1884445141,2
    --2401966(+) GTACAA/GTTTAA 2 -- int10--------
    rs1399556001,2
    --2402069(+) AGAGAC/TTTCGG 2 -- int10--------
    rs753087631,2
    --2402172(+) AGCACA/GGATAC 2 -- int11Minor allele frequency- G:0.01WA 118
    rs1434857491,2
    --2402200(+) TGTCCA/GTGGAG 2 -- int10--------
    rs1816400691,2
    --2402215(+) GTGGGA/GCGGAC 2 -- int10--------
    rs2018523851,2
    --2402234(+) CCTGCC/TTAGCC 2 -- int10--------
    rs1125399061,2
    C,--2402239(+) CTAGCA/C/TTTACA 2 -- int11CSA 2
    rs1842893901,2
    --2402266(+) ACGGCC/TCTCTC 2 -- int10--------
    rs2019317171,2
    F--2402274(+) CTCTCA/TCTCAG 2 -- int11Minor allele frequency- T:0.00EU 1321
    rs1402881211,2
    C,F,--2402298(+) GAGTAC/TGCGTC 4 Y syn11Minor allele frequency- T:0.00NA 4552
    rs1462304011,2
    C,--2402313(+) GCCCAC/TGCTGT 4 H syn11Minor allele frequency- T:0.00NA 4552
    rs2009696171,2
    --2402328(+) GCTGTA/GAAGAA 4 V syn10--------
    rs2004892771,2
    --2402341(+) CCGACA/GGCTAC 4 S G mis10--------
    rs1167703641,2
    C,F,--2402388(+) TTTACG/AGATTT 4 /T syn12Minor allele frequency- A:0.00WA NA 4668
    rs1818563731,2
    C,F,--2402427(+) GGAAGT/CGGACG 2 -- int11Minor allele frequency- C:0.00EU 1323
    rs1869865161,2
    C,--2402459(+) GTGTGC/TGGGTG 2 -- int11Minor allele frequency- T:0.00EU 1277
    rs1910574431,2
    --2402527(+) CTGCCA/GCAGAG 2 -- int10--------
    rs1484668651,2
    --2402633(+) GGCCAC/TGCTGG 2 -- int10--------
    rs1807356211,2
    C,--2402666(+) TAGTCA/GTCAGG 2 -- int10--------
    rs1423447051,2
    C,--2402676(+) GGCGTA/GGGGCT 2 -- int10--------
    rs1512821641,2
    C,--2402719(+) GATCAG/TTGACG 4 S I mis10--------
    rs1487851841,2
    C,F--2402724(+) GTGACG/AAGTGG 4 /K /E mis11Minor allele frequency- A:0.00NA 4552
    rs2021135911,2
    --2402792(+) CAGTGC/GTTTAA 2 -- int10--------
    rs1404388021,2
    --2402833(+) CTGCAA/GTCCCA 2 -- int10--------
    rs1866476341,2
    --2402870(+) ATCGCC/TTAAGC 2 -- int10--------
    rs1170420611,2
    --2402977(+) TATTCC/GCAGCT 2 -- int11Minor allele frequency- G:0.01EA 120
    rs38370791,2
    C--2403016(+) TTGAG-/CCTGGG
    AGGTTGAG
    GCTGC
    2 -- int11Minor allele frequency- CCTGGGAGGTTGAG:0.00NA 2
    rs37788951,2
    C,F,--2403063(+) TGATTG/ATGCCA 2 -- int111Minor allele frequency- A:0.17NA WA CSA EA 375
    rs795213491,2
    --2403128(+) TAGACG/AGTGTC 2 -- int13Minor allele frequency- A:0.06CSA WA 121
    rs1901582121,2
    --2403153(+) GGGTGC/TGACTT 2 -- int10--------
    rs1831526081,2
    --2403196(+) CTTTAA/GGAGCA 2 -- int10--------
    rs1453324601,2
    C,--2403240(+) GAAATG/TTTATA 2 -- int11Minor allele frequency- T:0.00EU 1299
    rs1498303301,2
    C,--2403253(+) TTGTC-/TTTTTGT 2 -- int10--------
    rs1875090871,2
    C,F,--2403255(+) TTGTCT/CTTGTT 2 -- int11Minor allele frequency- C:0.01EU 1321
    rs779817091,2
    C,--2403288(+) GGCTTG/TAAGAG 4 E * stg10--------
    rs1404905241,2
    C,F--2403371(+) AAAGAC/ACCTGT 4 /E /D mis11Minor allele frequency- A:0.00NA 4548
    rs2011066051,2
    --2403377(+) CCTGTC/GTCAAT 4 V syn10--------
    rs1122842351,2
    C--2403396(+) GAGCGA/C/GTGTGT 2 -- spd11CSA 1
    rs2003987971,2
    --2403413(+) TGCTGC/TTGGGG 2 -- int10--------
    rs607756581,2
    --2403693(+) AGATTT/GAGACC 2 -- int11Minor allele frequency- G:0.33CSA 3
    rs1904568941,2
    --2403706(+) CCTGGC/TTAACA 2 -- int10--------
    rs604987421,2
    --2403713(+) AACACA/GGTGAA 2 -- int11Minor allele frequency- G:0.00CSA 1
    rs1840950821,2
    --2403782(+) GTCCCC/TGCTAC 2 -- int10--------
    rs605385941,2
    --2403821(+) GAACCA/TGGGAG 2 -- int11Minor allele frequency- T:0.33CSA 3
    rs1886471831,2
    --2403854(+) ATTGCA/GCCACT 2 -- int10--------
    rs1169409101,2
    F,--2403911(+) AAGTTT/AGTAGA 2 -- int11Minor allele frequency- A:0.11NA 120
    rs1995070211,2
    --2403981(+) GTATTA/GACGTT 2 -- int10--------
    rs1388901821,2
    C,--2404002(+) TTTTCC/TGCAGA 2 -- int10--------
    rs617426691,2
    C,F,--2404135(+) GGGGTT/CCAGCT 4 /V syn13Minor allele frequency- C:0.02NS WA NA 4744
    rs1489881621,2
    --2404257(+) AACTTA/GGTAGA 2 -- int10--------
    rs1434893381,2
    --2404269(+) AAATAA/CGGGAG 2 -- int10--------
    rs1479980681,2
    --2404331(+) ATTTAC/TGTCAT 2 -- int10--------
    rs1927623361,2
    --2404416(+) GTGTAC/TTCCTA 2 -- int10--------
    rs46091061,2
    C,F,H,--2404455(+) GTGTGG/TGTACT 2 -- int120Minor allele frequency- T:0.45NS EA NA WA 2324
    rs765603411,2
    F,--2404539(+) ATGTTC/TTGTAT 2 -- int11Minor allele frequency- T:0.03NA 120
    rs1842434951,2
    --2404561(+) TCCTTC/TAGTTC 2 -- int10--------
    rs1871557021,2
    --2404572(+) AGGATC/GTAGTC 2 -- int10--------
    rs1424776231,2
    --2404594(+) ATTTTA/GCAGAT 2 -- int10--------
    rs102521121,2
    C,F,A,H,--2404657(+) ttgcaG/Agctca 2 -- int15Minor allele frequency- A:0.30WA CSA NA EA 362
    rs1916326291,2
    --2404749(+) CATATA/GGCTAA 2 -- int10--------
    rs624441631,2
    --2404881(+) CACCTG/AGCCGA 2 -- int11Minor allele frequency- A:0.50NA 2
    rs1385312431,2
    --2404889(+) CGAGCC/TGTGAT 2 -- int10--------
    rs125409571,2
    C,F,H,--2404912(+) TAATCC/TGGCTG 2 -- int14Minor allele frequency- T:0.02NS EA 390
    rs1508111351,2
    --2404913(+) AATCCA/GGCTGT 2 -- int10--------
    rs78108121,2
    C,F,A,H,--2404952(+) GTGGGA/CGGCAG 2 -- int18Minor allele frequency- C:0.21NS NA WA CSA EA 478
    rs1129758341,2
    --2405020(+) GCGAAC/TGGGGG 2 -- int11Minor allele frequency- T:0.50CSA 2
    rs78109441,2
    C,F,A,H,--2405028(+) GGGCCG/ACTCTA 2 -- int114Minor allele frequency- A:0.14NS EA NA WA CSA 779
    rs1844898161,2
    --2405061(+) GCAGTG/TCGAGG 2 -- int10--------
    rs77916791,2
    C,F,A,H,--2405127(+) GTGTTA/GTAAGG 2 -- int122Minor allele frequency- G:0.18NS EA NA WA CSA 2341
    rs1889428181,2
    --2405193(+) CAAGCC/GAGCAG 2 -- int10--------
    rs725691391,2
    C,F,--2405260(+) TGCTGA/GCTTTC 2 -- int15Minor allele frequency- G:0.38NA CSA EA 245
    rs2003810471,2
    --2405287(+) GTTTT-/TTTG  
            
    TTTGT
    2 -- int10--------
    rs102528371,2
    C,F,A,H,--2405290(+) TTTTTT/GTTTGT 2 -- int13Minor allele frequency- G:0.40NA WA CSA 5
    rs2010818021,2
    --2405290(+) TTTTT-/GTTTGT 2 -- int10--------
    rs1381376721,2
    --2405303(+) GTTTG-/TTTGTTT 2 -- int10--------
    rs1814932491,2
    --2405485(+) TTTGTA/GTTTTT 2 -- int10--------
    rs1440565021,2
    --2405549(+) CTCCGC/GACCTT 2 -- int10--------
    rs1125940361,2
    F,--2405656(+) ACATGG/AGTAAA 2 -- int13Minor allele frequency- A:0.05CSA WA 122
    rs730452071,2
    C,--2405683(+) GCGCCA/GCCCTC 2 -- int10--------
    rs42839331,2
    H--2405809(+) TTCCGC/ATTGGG 2 -- int14Minor allele frequency- A:0.00NS EA 416
    rs752118731,2
    C,--2405881(+) GTGTTG/CTGGCC 2 -- int11Minor allele frequency- C:0.50CSA 2
    rs22862041,2
    C,F,O,H,--2405885(+) TCTGGA/CCGCAC 2 -- int120Minor allele frequency- C:0.42EA MN NS NA CSA 4976
    rs1476569621,2
    C,--2405952(+) TCTAGA/GTACCT 4 R syn10--------
    rs1423774011,2
    C,--2405970(+) TTTAGC/TCCCCT 4 S syn10--------
    rs1449043261,2
    C,F,--2406051(+) TTTCAC/TTGTGA 4 H syn12Minor allele frequency- T:0.01NA EU 5875
    rs778116421,2
    --2406506(+) TGTCAC/TGCTCT 2 -- int12Minor allele frequency- T:0.09CSA WA 120
    rs1513347111,2
    --2406518(+) TGTGCA/GCTGCC 2 -- int10--------
    rs1406161481,2
    --2406573(+) GTTAGC/GTGTGT 2 -- int10--------
    rs1116103431,2
    F,--2406580(+) GTGTTA/TCTGAG 2 -- int12Minor allele frequency- T:0.40CSA 5
    rs1857459561,2
    C,--2406695(+) CTTATC/TAGTTT 2 -- int10--------
    rs1382729471,2
    C,--2406718(+) TGTTCA/GGGCTG 2 -- int10--------
    rs2020008791,2
    --2406721(+) TCAGGC/TTGCTT 2 -- int10--------
    rs603827611,2
    C--2406738(+) ATACC-/AAAAAA 2 -- int10--------
    rs736738131,2
    C,--2406749(+) AAAAAA/CAAAAA 2 -- int12Minor allele frequency- C:0.23WA 120
    rs1902692921,2
    --2406820(+) CTTGGC/GAGCTT 2 -- int10--------
    rs1810094901,2
    --2406821(+) TTGGGA/TGCTTG 2 -- int10--------
    rs582644421,2
    C,--2406835(+) TCAGGG/ATGCCT 2 -- int12Minor allele frequency- A:0.04WA 120
    rs750690531,2
    C,F,--2406890(+) CCTCGG/TTCCAG 2 -- int11Minor allele frequency- T:0.03WA 118
    rs102606031,2
    C,F,A,H,--2406925(+) GGCCTC/GTTCTG 2 -- int115Minor allele frequency- G:0.13NS EA NA WA CSA 787
    rs1995541681,2
    --2407009(+) CGTCA-/CCCCAG 2 -- int10--------
    rs1408601141,2
    --2407065(+) CCATTA/GCAGTT 2 -- int10--------
    rs1447126041,2
    --2407139(+) AGTCTA/CGCTCC 2 -- int10--------
    rs1858887971,2
    --2407145(+) GCTCCA/GTCAGG 2 -- int10--------
    rs1385273861,2
    --2407167(+) TGATAC/TGATCT 2 -- int10--------
    rs1415629801,2
    --2407223(+) CCTCAA/GCCTCC 2 -- int10--------
    rs1445948511,2
    --2407270(+) CGGCTA/GATTTT 2 -- int10--------
    rs1480517741,2
    --2407390(+) GAGCCA/TCCATG 2 -- int10--------
    rs102356521,2
    C,A,H--2407415(+) CAGTTC/TTTAAC 2 -- int14Minor allele frequency- T:0.00NS EA 412
    rs1888626981,2
    --2407436(+) GAAAAC/TGGTGA 2 -- int10--------
    rs1417998441,2
    --2407437(+) AAAACA/GGTGAG 2 -- int10--------
    rs1505500351,2
    --2407439(+) AACGGG/TGAGTT 2 -- int10--------
    rs779955251,2
    C--2407449(+) TTGTTC/TTTTTT 2 -- int10--------
    rs1812886061,2
    --2407527(+) GCTGGC/TGTAGA 2 -- int10--------
    rs1128226611,2
    --2407594(+) TGCCTC/TAGACT 2 -- int11Minor allele frequency- T:0.00CSA 1
    rs1855493261,2
    --2407665(+) TAGAGA/TTGGGG 2 -- int10--------
    rs1439120871,2
    --2407689(+) GCCATC/GCTGGT 2 -- int10--------
    rs1907025671,2
    --2407766(+) GAGCCA/CCCACA 2 -- int10--------
    rs1162227751,2
    F,--2407853(+) GCTGAC/TTGCAG 2 -- int11Minor allele frequency- T:0.05WA 118
    rs1114162001,2
    --2408050(+) AAAGTG/TCAGGG 2 -- int11Minor allele frequency- T:0.50CSA 2
    rs1457198331,2
    --2408151(+) CAGCAC/TTGGGC 2 -- int10--------
    rs1485732151,2
    --2408168(+) CCCTTA/GAGGCA 2 -- int10--------
    rs1429788291,2
    --2408206(+) AGAAAA/TGAATT 2 -- int10--------
    rs1123112721,2
    C,--2408214(+) ATTTTC/TAAGGC 2 -- int12Minor allele frequency- T:0.06CSA WA 119
    rs1833249641,2
    --2408420(+) TATCGA/CAAAAC 2 -- int10--------
    rs37350941,2
    C,H,--2408435(+) GACTGG/ATCAGT 2 -- int15Minor allele frequency- A:0.00EA NS 1912
    rs14197211,2
    C,A,H,--2408479(+) ATTGAC/TGTTTC 2 -- int18Minor allele frequency- T:0.01MN NS EA NA WA 702
    rs1510865671,2
    --2408511(+) GGGCAA/GAATTA 2 -- int10--------
    rs754714831,2
    F,--2408538(+) AAGACC/GAGGAC 2 -- int11Minor allele frequency- G:0.02NA 120
    rs1413757871,2
    --2408618(+) GAGCCA/GTTCGT 2 -- int10--------
    rs1145207451,2
    F,--2408624(+) TTCGTT/CACAGC 2 -- int11Minor allele frequency- C:0.03WA 118
    rs1446537111,2
    --2408685(+) GCTCAA/TTCCTT 2 -- int10--------
    rs1919222721,2
    --2408788(+) AGCAGC/GAGTGT 2 -- int10--------
    rs736738141,2
    C,F,--2408817(+) GCTGAC/TGGAGC 2 -- int14Minor allele frequency- T:0.24WA CSA 124
    rs1467060091,2
    --2408948(+) CTGCGC/TGGCAT 2 -- int10--------
    rs1830206101,2
    --2408956(+) CATGCC/GCAGAG 2 -- int10--------
    rs1866337721,2
    --2408986(+) GCGCTC/TAGCGT 2 -- int10--------
    rs1154496321,2
    --2408990(+) TCAGCG/CTCAGC 2 -- int11Minor allele frequency- C:0.01WA 118
    rs1125804981,2
    --2409014(+) AGCTTC/TTATAT 2 -- int11Minor allele frequency- T:0.50CSA 2
    rs23019441,2
    C,F,A,H,--2409035(+) TTGTTT/CTATTC 2 -- int128Minor allele frequency- C:0.11EA NS NA WA CSA 4207
    rs1502901101,2
    C,--2409060(+) GTTTCA/GTCATC 2 -- int10--------
    rs2005371321,2
    --2409068(+) ATCACG/TTGGTC 2 -- int10--------
    rs1910867901,2
    C,--2409096(+) TTTTCC/TTGTTC 2 -- int10--------
    rs605450871,2
    C,--2409103(+) GTTCTG/ACAGAG 2 -- int12Minor allele frequency- A:0.08CSA WA 120
    rs1825495631,2
    C,--2409203(+) CCTACC/TAGGCA 4 T syn10--------
    rs1379102001,2
    C,--2409349(+) GATTCC/TTTATC 2 -- int10--------
    rs710265071,2
    C--2409401(+) TTTTGT/-AGATG 2 -- int11Minor allele frequency- -:0.00NA 2
    rs1495260551,2
    --2409432(+) TTTTGA/GGATGG 2 -- int10--------
    rs1432069731,2
    --2409489(+) TCACTA/GCAGTC 2 -- int10--------
    rs1868757171,2
    --2409499(+) CTCTGC/TCTCCT 2 -- int10--------
    rs1388063991,2
    --2409532(+) TCAGCG/TTCCCA 2 -- int10--------
    rs1931749661,2
    --2409672(+) CACCCA/GAAGGG 2 -- int10--------
    rs69465031,2
    C,H--2409714(+) gcTGAG/AAATAT 2 -- int14Minor allele frequency- A:0.00NS EA 404
    rs1850788921,2
    --2409765(+) TATTTA/TTTTAT 2 -- int10--------
    rs1428251431,2
    --2409833(+) TTGGCA/TGGGTG 2 -- int10--------
    rs1907698011,2
    --2409865(+) CCAGCA/CCTTTG 2 -- int10--------
    rs1474088061,2
    --2409877(+) GAGGCC/TGAGGT 2 -- int10--------
    rs1930823171,2
    --2409994(+) GTAGTC/TCCAGC 2 -- int10--------
    rs47216501,2