Aliases for EIF3B Gene
External Ids for EIF3B Gene
Previous Symbols for EIF3B Gene
GeneCards Summary for EIF3B Gene
EIF3B (Eukaryotic Translation Initiation Factor 3, Subunit B) is a Protein Coding gene. Among its related pathways are p70S6K Signaling and Apoptotic Pathways in Synovial Fibroblasts. GO annotations related to this gene include nucleotide binding and protein complex scaffold.
UniProtKB/Swiss-Prot for EIF3B Gene
Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation.