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Aliases for EIF3B Gene

Aliases for EIF3B Gene

  • Eukaryotic Translation Initiation Factor 3 Subunit B 2 3 5
  • Eukaryotic Translation Initiation Factor 3, Subunit 9 Eta, 116kDa 2 3
  • Eukaryotic Translation Initiation Factor 3 Subunit 9 3 4
  • Prt1 Homolog 3 4
  • EIF3 P110 3 4
  • EIF3 P116 3 4
  • EIF-3-Eta 3 4
  • EIF3S9 3 4
  • HPrt1 3 4
  • Eukaryotic Translation Initiation Factor 3, Subunit 9 (Eta, 116kD) 3
  • Eukaryotic Translation Initiation Factor 3, Subunit B 2
  • EIF3-P110 3
  • EIF3-P116 3
  • EIF3-ETA 3
  • EIF3b 4
  • PRT1 3

External Ids for EIF3B Gene

Previous HGNC Symbols for EIF3B Gene

  • EIF3S9

Previous GeneCards Identifiers for EIF3B Gene

  • GC07P002362

Summaries for EIF3B Gene

GeneCards Summary for EIF3B Gene

EIF3B (Eukaryotic Translation Initiation Factor 3 Subunit B) is a Protein Coding gene. Among its related pathways are Viral mRNA Translation and Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S. GO annotations related to this gene include nucleic acid binding and nucleotide binding.

UniProtKB/Swiss-Prot for EIF3B Gene

  • RNA-binding component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis (PubMed:9388245, PubMed:17581632, PubMed:25849773, PubMed:27462815). The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation (PubMed:9388245, PubMed:17581632). The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, including cell cycling, differentiation and apoptosis, and uses different modes of RNA stem-loop binding to exert either translational activation or repression (PubMed:25849773).

  • (Microbial infection) In case of FCV infection, plays a role in the ribosomal termination-reinitiation event leading to the translation of VP2 (PubMed:18056426).

Gene Wiki entry for EIF3B Gene

Additional gene information for EIF3B Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for EIF3B Gene

Genomics for EIF3B Gene

Regulatory Elements for EIF3B Gene

Enhancers for EIF3B Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH07H002352 1.4 ENCODE dbSUPER 33.8 +0.9 876 3 PKNOX1 ARNT ARID4B SIN3A DMAP1 ZBTB7B YY1 SLC30A9 ZNF766 CBX5 EIF3B BRAT1 INTS1 GC07M002353 SNX8
GH07H001502 1.7 FANTOM5 ENCODE dbSUPER 21.7 -848.3 -848345 6 HDGF PKNOX1 FOXA2 ARNT ZFP64 ARID4B SIN3A YBX1 DMAP1 ZBTB7B INTS1 EIF3B SUN1 DNAAF5 ENSG00000231927
GH07H002841 1.3 ENCODE dbSUPER 23.1 +489.6 489634 4 HDGF PKNOX1 ATF1 ARNT ARID4B SIN3A DMAP1 YY1 TCF12 ZNF121 GNA12 EIF3B BRAT1 LOC100131264
GH07H002619 1.9 FANTOM5 Ensembl ENCODE dbSUPER 15.1 +268.7 268659 5 MLX ARID4B DMAP1 SLC30A9 GTF3C2 FOS ATF7 SP5 ZHX2 MXD4 BRAT1 TTYH3 EIF3B AMZ1 IQCE MRM2 GC07P002574
GH07H002553 1 ENCODE 24.2 +201.2 201216 2 HDGF ARID4B SIN3A BRCA1 ZBTB7B ZNF121 SLC30A9 GTF3C2 GLIS2 ELK1 BRAT1 EIF3B MRM2 PIR48387
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around EIF3B on UCSC Golden Path with GeneCards custom track

Promoters for EIF3B Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000207760 714 2801 PKNOX1 FOXA2 ARNT ARID4B SIN3A DMAP1 ZBTB7B YY1 SLC30A9 ZNF766

Genomic Location for EIF3B Gene

Chromosome:
7
Start:
2,354,086 bp from pter
End:
2,380,745 bp from pter
Size:
26,660 bases
Orientation:
Plus strand

Genomic View for EIF3B Gene

Genes around EIF3B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
EIF3B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for EIF3B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for EIF3B Gene

Proteins for EIF3B Gene

  • Protein details for EIF3B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P55884-EIF3B_HUMAN
    Recommended name:
    Eukaryotic translation initiation factor 3 subunit B
    Protein Accession:
    P55884
    Secondary Accessions:
    • A4D208
    • Q2NL77
    • Q9UMF9

    Protein attributes for EIF3B Gene

    Size:
    814 amino acids
    Molecular mass:
    92482 Da
    Quaternary structure:
    • Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is composed of 13 subunits: EIF3A, EIF3B, EIF3C, EIF3D, EIF3E, EIF3F, EIF3G, EIF3H, EIF3I, EIF3J, EIF3K, EIF3L and EIF3M. The eIF-3 complex appears to include 3 stable modules: module A is composed of EIF3A, EIF3B, EIF3G and EIF3I; module B is composed of EIF3F, EIF3H, and EIF3M; and module C is composed of EIF3C, EIF3D, EIF3E, EIF3K and EIF3L. EIF3C of module C binds EIF3B of module A and EIF3H of module B, thereby linking the three modules. EIF3J is a labile subunit that binds to the eIF-3 complex via EIF3B. The eIF-3 complex interacts with RPS6KB1 under conditions of nutrient depletion. Mitogenic stimulation leads to binding and activation of a complex composed of MTOR and RPTOR, leading to phosphorylation and release of RPS6KB1 and binding of EIF4B to eIF-3. Also interacts with UPF2 and HNRPD. Interacts with METTL3 (PubMed:27117702).

    Three dimensional structures from OCA and Proteopedia for EIF3B Gene

    Alternative splice isoforms for EIF3B Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for EIF3B Gene

Post-translational modifications for EIF3B Gene

  • Phosphorylated. Phosphorylation is enhanced upon serum stimulation.
  • Ubiquitination at isoforms=2209, isoforms=2230, isoforms=2257, isoforms=2288, isoforms=2324, isoforms=2345, posLast=364364, posLast=516516, posLast=535535, posLast=552552, posLast=604604, posLast=718718, isoforms=2729, posLast=744744, and isoforms=2762
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for EIF3B Gene

Domains & Families for EIF3B Gene

Gene Families for EIF3B Gene

Graphical View of Domain Structure for InterPro Entry

P55884

UniProtKB/Swiss-Prot:

EIF3B_HUMAN :
  • The RRM domain mediates interaction with EIF3J.
  • Belongs to the eIF-3 subunit B family.
Domain:
  • The RRM domain mediates interaction with EIF3J.
Family:
  • Belongs to the eIF-3 subunit B family.
genes like me logo Genes that share domains with EIF3B: view

Function for EIF3B Gene

Molecular function for EIF3B Gene

UniProtKB/Swiss-Prot Function:
RNA-binding component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis (PubMed:9388245, PubMed:17581632, PubMed:25849773, PubMed:27462815). The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation (PubMed:9388245, PubMed:17581632). The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, including cell cycling, differentiation and apoptosis, and uses different modes of RNA stem-loop binding to exert either translational activation or repression (PubMed:25849773).
UniProtKB/Swiss-Prot Function:
(Microbial infection) In case of FCV infection, plays a role in the ribosomal termination-reinitiation event leading to the translation of VP2 (PubMed:18056426).

Phenotypes From GWAS Catalog for EIF3B Gene

Gene Ontology (GO) - Molecular Function for EIF3B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003676 nucleic acid binding IEA --
GO:0003723 RNA binding IDA 25849773
GO:0003743 contributes_to translation initiation factor activity IDA 17581632
GO:0005515 protein binding IPI 11169732
GO:0031369 translation initiation factor binding IEA --
genes like me logo Genes that share ontologies with EIF3B: view
genes like me logo Genes that share phenotypes with EIF3B: view

Animal Models for EIF3B Gene

MGI Knock Outs for EIF3B:

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for EIF3B
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for EIF3B Gene

Localization for EIF3B Gene

Subcellular locations from UniProtKB/Swiss-Prot for EIF3B Gene

Cytoplasm.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for EIF3B gene
Compartment Confidence
extracellular 5
cytosol 5
nucleus 4

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (2)
  • Nucleoplasm (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for EIF3B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
GO:0005829 cytosol TAS --
GO:0005852 eukaryotic translation initiation factor 3 complex IDA 8995410
GO:0016282 eukaryotic 43S preinitiation complex IEA --
GO:0033290 eukaryotic 48S preinitiation complex IEA --
genes like me logo Genes that share ontologies with EIF3B: view

Pathways & Interactions for EIF3B Gene

genes like me logo Genes that share pathways with EIF3B: view

Gene Ontology (GO) - Biological Process for EIF3B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006412 translation IEA --
GO:0006413 translational initiation TAS --
GO:0006446 regulation of translational initiation IDA 8995410
GO:0075522 IRES-dependent viral translational initiation IDA 9573242
GO:0075525 viral translational termination-reinitiation IDA 21347434
genes like me logo Genes that share ontologies with EIF3B: view

No data available for SIGNOR curated interactions for EIF3B Gene

Drugs & Compounds for EIF3B Gene

(1) Drugs for EIF3B Gene - From: ApexBio

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
eukaryotic translation initiation factor 3 Pharma Eukaryotic translation initiator 0

(1) ApexBio Compounds for EIF3B Gene

Compound Action Cas Number
eukaryotic translation initiation factor 3 Eukaryotic translation initiator
genes like me logo Genes that share compounds with EIF3B: view

Drug Products

Transcripts for EIF3B Gene

Unigene Clusters for EIF3B Gene

Eukaryotic translation initiation factor 3, subunit B:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for EIF3B
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for EIF3B Gene

ExUns: 1 ^ 2 ^ 3a · 3b · 3c ^ 4a · 4b ^ 5a · 5b ^ 6a · 6b ^ 7a · 7b ^ 8a · 8b ^ 9a · 9b · 9c ^ 10 ^ 11a · 11b ^ 12a · 12b ^ 13 ^ 14 ^ 15a ·
SP1: - - - -
SP2: - - - -
SP3: - - - -
SP4: - - - -
SP5: - - - -
SP6: -
SP7: - - - - - - - - - - - - - -
SP8:
SP9:
SP10: - - -
SP11:
SP12:
SP13: - - - -
SP14:
SP15: -
SP16:
SP17:
SP18: - -

ExUns: 15b · 15c ^ 16 ^ 17a · 17b ^ 18 ^ 19a · 19b · 19c ^ 20a · 20b ^ 21 ^ 22a · 22b ^ 23a · 23b ^ 24a · 24b · 24c
SP1: - - - - - -
SP2: - - - -
SP3: - - - - -
SP4: - - - - -
SP5:
SP6:
SP7: - -
SP8: - -
SP9: - -
SP10:
SP11:
SP12: - - -
SP13:
SP14:
SP15:
SP16:
SP17:
SP18:

Relevant External Links for EIF3B Gene

GeneLoc Exon Structure for
EIF3B
ECgene alternative splicing isoforms for
EIF3B

Expression for EIF3B Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for EIF3B Gene

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for EIF3B Gene



Protein tissue co-expression partners for EIF3B Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of EIF3B Gene:

EIF3B

SOURCE GeneReport for Unigene cluster for EIF3B Gene:

Hs.371001

Evidence on tissue expression from TISSUES for EIF3B Gene

  • Nervous system(4.8)
  • Liver(4.4)
  • Muscle(4.4)
  • Intestine(4)
  • Skin(3.6)
  • Lung(3.5)
  • Pancreas(3)
  • Eye(2.4)
  • Kidney(2.4)
  • Spleen(2)
genes like me logo Genes that share expression patterns with EIF3B: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for EIF3B Gene

Orthologs for EIF3B Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for EIF3B Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia EIF3B 33 34
  • 99.34 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia EIF3B 34
  • 98 (a)
OneToOne
dog
(Canis familiaris)
Mammalia EIF3B 33 34
  • 89.46 (n)
cow
(Bos Taurus)
Mammalia EIF3B 33 34
  • 86.98 (n)
rat
(Rattus norvegicus)
Mammalia Eif3b 33
  • 85.11 (n)
mouse
(Mus musculus)
Mammalia Eif3b 33 16 34
  • 85.01 (n)
oppossum
(Monodelphis domestica)
Mammalia EIF3B 34
  • 85 (a)
OneToOne
chicken
(Gallus gallus)
Aves EIF3B 33 34
  • 78.95 (n)
lizard
(Anolis carolinensis)
Reptilia -- 34
  • 73 (a)
OneToMany
-- 34
  • 59 (a)
OneToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia eif3b 33
  • 77.33 (n)
Str.6777 33
African clawed frog
(Xenopus laevis)
Amphibia Xl.26073 33
zebrafish
(Danio rerio)
Actinopterygii eif3bb 34
  • 84 (a)
OneToMany
eif3ba 33 34
  • 76.93 (n)
wufc17c01 33
fruit fly
(Drosophila melanogaster)
Insecta eIF3-S9 33 34
  • 58.46 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta EIF3B_ANOGA 33
  • 56.06 (n)
worm
(Caenorhabditis elegans)
Secernentea eif-3.B 34
  • 34 (a)
OneToOne
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_ADR399C 33
  • 48.48 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes PRT1 33 34 36
  • 48.34 (n)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0A03531g 33
  • 47.66 (n)
thale cress
(Arabidopsis thaliana)
eudicotyledons EIF3B-2 33
  • 53.14 (n)
rice
(Oryza sativa)
Liliopsida Os10g0569200 33
  • 53.08 (n)
Os.4899 33
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 60 (a)
OneToMany
CSA.6899 34
  • 60 (a)
OneToMany
bread mold
(Neurospora crassa)
Ascomycetes NCU02208 33
  • 52.57 (n)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes SPAC25G10.08 33
  • 49.61 (n)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.3078 33
Species where no ortholog for EIF3B was found in the sources mined by GeneCards:
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for EIF3B Gene

ENSEMBL:
Gene Tree for EIF3B (if available)
TreeFam:
Gene Tree for EIF3B (if available)

Paralogs for EIF3B Gene

(1) SIMAP similar genes for EIF3B Gene using alignment to 7 proteins:

genes like me logo Genes that share paralogs with EIF3B: view

No data available for Paralogs for EIF3B Gene

Variants for EIF3B Gene

Sequence variations from dbSNP and Humsavar for EIF3B Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type
rs1000131695 -- 2,361,936(+) CACGC(C/G)TGGCT intron-variant
rs1000292747 -- 2,361,754(+) ATACA(C/T)AATAT intron-variant
rs1000361254 -- 2,369,053(+) CATTC(C/G)TTACA intron-variant
rs1000569310 -- 2,352,884(+) GAAAC(C/T)GAGGT intron-variant, upstream-variant-2KB
rs1000572141 -- 2,353,252(+) GGTGG(A/T)TCACG intron-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for EIF3B Gene

Variant ID Type Subtype PubMed ID
dgv1071e201 CNV deletion 23290073
dgv227n6 CNV deletion 16902084
esv1406872 CNV deletion 17803354
esv2140457 CNV deletion 18987734
esv2424013 CNV deletion 19546169
esv2663485 CNV deletion 23128226
esv26940 CNV gain 19812545
esv2733845 CNV deletion 23290073
esv2733846 CNV deletion 23290073
esv2733848 CNV deletion 23290073
esv2733849 CNV deletion 23290073
esv2733851 CNV deletion 23290073
esv3541044 CNV deletion 23714750
nsv1032737 CNV gain 25217958
nsv366196 CNV deletion 16902084
nsv950791 CNV deletion 24416366

Variation tolerance for EIF3B Gene

Residual Variation Intolerance Score: 7.61% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.55; 55.89% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for EIF3B Gene

Human Gene Mutation Database (HGMD)
EIF3B
SNPedia medical, phenotypic, and genealogical associations of SNPs for
EIF3B

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for EIF3B Gene

Disorders for EIF3B Gene

Relevant External Links for EIF3B

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
EIF3B

No disorders were found for EIF3B Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for EIF3B Gene

Publications for EIF3B Gene

  1. The human homologue of the yeast Prt1 protein is an integral part of the eukaryotic initiation factor 3 complex and interacts with p170. (PMID: 8995410) Méthot N … Sonenberg N (The Journal of biological chemistry 1997) 2 3 4 22 60
  2. Molecular interaction between human tumor marker protein p150, the largest subunit of eIF3, and intermediate filament protein K7. (PMID: 11169732) Lin L … Burger MM (Journal of cellular biochemistry 2001) 3 4 22 60
  3. Biochemical characterization of mammalian translation initiation factor 3 (eIF3). Molecular cloning reveals that p110 subunit is the mammalian homologue of Saccharomyces cerevisiae protein Prt1. (PMID: 9388245) Chaudhuri J … Maitra U (The Journal of biological chemistry 1997) 3 4 22 60
  4. eIF3d is an mRNA cap-binding protein that is required for specialized translation initiation. (PMID: 27462815) Lee AS … Cate JH (Nature 2016) 3 4 60
  5. eIF3 targets cell-proliferation messenger RNAs for translational activation or repression. (PMID: 25849773) Lee AS … Cate JH (Nature 2015) 3 4 60

Products for EIF3B Gene

Sources for EIF3B Gene

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