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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

EIF3B Gene

protein-coding   GIFtS: 57
GCID: GC07P002362

eukaryotic translation initiation factor 3, subunit B

(Previous names: eukaryotic translation initiation factor 3, subunit 9 eta,...)
(Previous symbol: EIF3S9)
 Explore 4 diseases affiliated with
EIF3B via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for EIF3B    

Aliases
for EIF3B gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Eukaryotic Translation Initiation Factor 3, Subunit B1 2     EIF3 P1102 3
EIF3S91 2 3 5     EIF3 P1162 3
PRT11 2 5     HPrt11
Eukaryotic Translation Initiation Factor 3, Subunit 9 Eta, 116kDa1 2     EIF3-ETA2
EIF3b1     EIF3-P1102
Eukaryotic Translation Initiation Factor 3 Subunit 92 3     EIF3-P1162
Prt1 Homolog2 3     Eukaryotic Translation Initiation Factor 3 Subunit B2
EIF-3-Eta1     Eukaryotic Translation Initiation Factor 3, Subunit 9 (Eta, 116kD)2

External Ids:    HGNC: 32801   Entrez Gene: 86622   Ensembl: ENSG000001062637   OMIM: 6039175   UniProtKB: P558843   

Export aliases for EIF3B gene to outside databases


Summaries
for EIF3B gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
UniProtKB/Swiss-Prot: EIF3B_HUMAN, P55884
Function: Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several
steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and facilitates the
recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S preinitiation complex (43S PIC). The
eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3
complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently
prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation

Gene Wiki entry for EIF3B


Genomic Views
for EIF3B gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000007.13  NC_018918.1  NT_007819.17  NT_079592.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the EIF3B gene promoter:
         Max1   Pax-5   NF-E2 p45   Egr-4   AREB6   Pax-4a   NF-E2   ATF   ATF6   c-Myc   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 11): EIF3B promoter sequence
   Search SABiosciences Chromatin IP Primers for EIF3B

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat EIF3B


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 7p22.3   Ensembl cytogenetic band:  7p22.3   HGNC cytogenetic band: 7p22

EIF3B Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
EIF3B gene location

GeneLoc information about chromosome 7         GeneLoc Exon Structure

GeneLoc location for GC07P002362:  view genomic region     (about GC identifiers)

Start:
 2,393,721 bp from pter      End:
 2,420,380 bp from pter
Size:
 26,660 bases      Orientation:
 plus strand

1 alternative location:
Chr7+,CRA_TCAG 2,442,541-2,468,274     

Proteins
for EIF3B gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: EIF3B_HUMAN, P55884 (See protein sequence)
Recommended Name: Eukaryotic translation initiation factor 3 subunit B  
Size: 814 amino acids; 92482 Da
Subunit: Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is composed of 13 subunits:
EIF3A, EIF3B, EIF3C, EIF3D, EIF3E, EIF3F, EIF3G, EIF3H, EIF3I, EIF3J, EIF3K, EIF3L and EIF3M. The eIF-3 complex
appears to include 3 stable modules: module A is composed of EIF3A, EIF3B, EIF3G and EIF3I; module B is composed of
EIF3F, EIF3H, and EIF3M; and module C is composed of EIF3C, EIF3D, EIF3E, EIF3K and EIF3L. EIF3C of module C binds
EIF3B of module A and EIF3H of module B, thereby linking the three modules. EIF3J is a labile subunit that binds to
the eIF-3 complex via EIF3B. The eIF-3 complex interacts with RPS6KB1 under conditions of nutrient depletion.
Mitogenic stimulation leads to binding and activation of a complex composed of MTOR and RPTOR, leading to
phosphorylation and release of RPS6KB1 and binding of EIF4B to eIF-3. Also interacts with UPF2
Subcellular location: Cytoplasm (By similarity)
Mass spectrometry: Mass=93093.7; Method=Unknown; Range=1-814; Source=PubMed:17322308;
Mass spectrometry: Mass=92561; Mass_error=43.5; Method=MALDI; Range=1-814; Source=PubMed:18599441;
2 PDB 3D structures from and Proteopedia for EIF3B:
2KRB (3D)        2NLW (3D)    
Secondary accessions: A4D208 Q2NL77 Q9UMF9
Alternative splicing: 2 isoforms:  P55884-1   P55884-2   

Explore the universe of human proteins at neXtProt for EIF3B: NX_P55884

Post-translational modifications:

  • Phosphorylated. Phosphorylation is enhanced upon serum stimulation1
  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_P55884

    • EIF3B Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins (2 alternative transcripts): 
    NP_001032360.1  NP_003742.2  

    ENSEMBL proteins: 
     ENSP00000408062   ENSP00000354125   ENSP00000407785   ENSP00000380206  
    Reactome Protein details: P55884
    Human Recombinant Protein Products: 
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    Uscn Proteins for EIF3B

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005829cytosol TAS--
    GO:0005852eukaryotic translation initiation factor 3 complex IDA17581632


    EIF3B for ontologies           About GeneDecksing



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    Uscn ELISAs and CLIAs for EIF3B

    Protein Domains /
    Families
    for EIF3B gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    EIF3B for domains           About GeneDecksing

    5 InterPro domains/families:
     IPR013979 TIF2A_beta_prop-like
     IPR000504 RRM_dom
     IPR012677 Nucleotide-bd_a/b_plait
     IPR015943 WD40/YVTN_repeat-like_dom
     IPR011400 eIF3b

    Graphical View of Domain Structure for InterPro Entry P55884

    ProtoNet protein and cluster: P55884

    2 Blocks protein families:
    IPB000504 RNA-binding region RNP-1 (RNA recognition motif)
    IPB013979 Eukaryotic translation initiation factor 2A


    UniProtKB/Swiss-Prot: EIF3B_HUMAN, P55884
    Domain: The RRM domain mediates interaction with EIF3J
    Similarity: Belongs to the eIF-3 subunit B family
    Similarity: Contains 1 RRM (RNA recognition motif) domain
    Similarity: Contains 5 WD repeats


    Function
    for EIF3B gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: EIF3B_HUMAN, P55884
    Function: Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several
    steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and facilitates the
    recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S preinitiation complex (43S PIC). The
    eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3
    complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently
    prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation

    miRNA
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    hsa-miR-3140-3p hsa-miR-124 hsa-miR-198 hsa-miR-525-5p hsa-miR-506 hsa-miR-520a-5p
    SwitchGear 3'UTR luciferase reporter plasmid: EIF3B 3' UTR sequence
    Inhib. RNA
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    Gene Editing
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    Clone
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    In Situ Assay
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         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for EIF3B

    Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000166nucleotide binding IEA--
    GO:0003743contributes to translation initiation factor activity IDA17581632
    GO:0005515protein binding IPI18628297
    GO:0032947protein complex scaffold TAS17322308


    EIF3B for ontologies           About GeneDecksing


    5 GenomeRNAi human phenotypes for EIF3B:
     Decreased G3BP1 protein expres  Decreased viability of wild-ty  Increased cell death in HCT116  Nuclear 60S biogenesis defects 
     Nucleolar pre-40S maturation d 


    Pathways & Interactions
    for EIF3B gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways - 5/7 super-pathways (see all 7) About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Synthesis of PB1-F2
    		Formation of a pool of free 40S subunits0.87
    		Eukaryotic Translation Initiation0.73
    		L13a-mediated translational silencing of Ceruloplasmin expression0.79
    		Cap-dependent Translation Initiation0.73
    		3' -UTR-mediated translational regulation0.79
    		Translation0.57
    		GTP hydrolysis and joining of the 60S ribosomal subunit0.78
    2Translation initiation complex formation
    		Translation initiation complex formation1.00
    		Ribosomal scanning and start codon recognition0.96
    		Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S0.98
    		Formation of the ternary complex, and subsequently, the 43S complex0.87
    3IL-2 Signaling Pathway
    		IL-2 Signaling Pathway1.00
    4Translation Factors
    		Translation Factors1.00
    5RNA transport
    		RNA transport1.00

    Pathway sources
    See GeneCards unified pathways
    Show all pathways


    2 BioSystems Pathways for EIF3B 
        Translation Factors
    IL-2 Signaling Pathway

    5/13        Reactome Pathways for EIF3B (see all 13)
        Formation of the ternary complex, and subsequently, the 43S complex
    Translation
    GTP hydrolysis and joining of the 60S ribosomal subunit
    Eukaryotic Translation Initiation
    Ribosomal scanning and start codon recognition


    1         Kegg Pathway  (Kegg details for EIF3B):
        RNA transport


    EIF3B for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for EIF3B

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    687/735 Interacting proteins for EIF3B (P558841, 2, 3 ENSP000003541254) via UniProtKB, MINT, STRING, and/or I2D (see all 735) (see top 5)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    HIST1H4AP628053I2D: score=1 
    HIST1H4BP628053I2D: score=1 
    HIST1H4CP628053I2D: score=1 
    HIST1H4DP628053I2D: score=1 
    HIST1H4EP628053I2D: score=1 
    HIST1H4FP628053I2D: score=1 
    HIST1H4HP628053I2D: score=1 
    HIST1H4IP628053I2D: score=1 
    HIST1H4JP628053I2D: score=1 
    HIST1H4KP628053I2D: score=1 
    HIST1H4LP628053I2D: score=1 
    HIST2H4AP628053I2D: score=1 
    HIST2H4BP628053I2D: score=1 
    HIST4H4P628053I2D: score=1 
    EIF3IQ133471, 2, 3, ENSP000003626884EBI-366696,EBI-354047 MINT-7947479 I2D: score=13 STRING: ENSP00000362688
    EIF3CQ996132, 3, ENSP000003326044MINT-6948891 I2D: score=6 STRING: ENSP00000332604
    EIF3CLQ996132, 3, ENSP000003702584MINT-6948891 I2D: score=6 STRING: ENSP00000370258
    EIF3FO003032, 3, ENSP000003100404MINT-6948891 MINT-6948874 I2D: score=2 STRING: ENSP00000310040
    EIF4G1Q046372, 3, ENSP000003168794MINT-8409716 I2D: score=3 STRING: ENSP00000316879
    PLRG1O436602, 3, ENSP000003031914MINT-7947479 I2D: score=3 STRING: ENSP00000303191
    DNAJA1P316892, 3MINT-7947479 I2D: score=2 
    ETF1P624952, 3MINT-7947479 I2D: score=2 
    HSPA8P111422, 3MINT-7947479 I2D: score=2 
    RUVBL2Q9Y2302, 3MINT-7947479 I2D: score=2 
    ACTBP607092, 3MINT-7947479 I2D: score=1 
    ACTR2P611602, 3MINT-7947479 I2D: score=1 
    CCT3P493682, 3MINT-7947479 I2D: score=1 
    DDX6P261962, 3MINT-7947479 I2D: score=1 
    HSP90AA1P079002, 3MINT-7947479 I2D: score=1 
    HSPA5P110212, 3MINT-7947479 I2D: score=1 
    PLK1P533502, 3MINT-7947479 I2D: score=1 
    PSMD2Q132002, 3MINT-7947479 I2D: score=1 
    RBBP4Q090282, 3MINT-7947479 I2D: score=1 
    SUPT16HQ9Y5B92, 3MINT-7947479 I2D: score=1 
    TCP1P179872, 3MINT-7947479 I2D: score=1 
    UBA5Q9GZZ92, 3MINT-7947479 I2D: score=1 
    UPF2Q9HAU52, 3MINT-7947479 I2D: score=1 
    EIF3AQ141521, 2, 3, ENSP000003581404EBI-366696,EBI-366617 MINT-6948891 I2D: score=17 STRING: ENSP00000358140
    EIF3GO758211, 2, 3, ENSP000002531084EBI-366696,EBI-366632 MINT-7947479 I2D: score=11 STRING: ENSP00000253108
    DDX3XO005711, 2, 3, ENSP000003828404EBI-366696,EBI-353779 MINT-7947479 I2D: score=1 STRING: ENSP00000382840
    EIF3JO758221, 3, ENSP000002618684EBI-366696,EBI-366647 I2D: score=4 STRING: ENSP00000261868
    EIF4A1P608422, 3, ENSP000002938314MINT-7947479 I2D: score=3 STRING: ENSP00000293831
    UPF1Q929002, 3, ENSP000002628034MINT-7947479 I2D: score=1 STRING: ENSP00000262803
    KPNB1Q149742, 3, ENSP000002901584MINT-7947479 I2D: score=3 STRING: ENSP00000290158
    EIF2S3P410912, 3, ENSP000002530394MINT-7947479 I2D: score=3 STRING: ENSP00000253039
    RPS13P622772, 3, ENSP000002281404MINT-7947479 I2D: score=2 STRING: ENSP00000228140
    EIF1P415673, ENSP000004194494I2D: score=7 STRING: ENSP00000419449
    EIF5P550103, ENSP000002165544I2D: score=7 STRING: ENSP00000216554
    ADSLP305663, ENSP000002161944I2D: score=4 STRING: ENSP00000216194
    EIF2S1P051983, ENSP000002563834I2D: score=4 STRING: ENSP00000256383
    GNB2L1P632443, ENSP000003660134I2D: score=4 STRING: ENSP00000366013
    HAT1O149293, ENSP000002641084I2D: score=4 STRING: ENSP00000264108
    CWC22Q9HCG83, ENSP000003870064I2D: score=3 STRING: ENSP00000387006
    EIF2S2P200423, ENSP000003641194I2D: score=3 STRING: ENSP00000364119
    NAA10P412273, ENSP000004177634I2D: score=3 STRING: ENSP00000417763
    NHP2L1P557693, ENSP000002159564I2D: score=3 STRING: ENSP00000215956
    POLE2P562823, ENSP000002163674I2D: score=3 STRING: ENSP00000216367
    RPS6KB1P234433, ENSP000002255774I2D: score=3 STRING: ENSP00000225577
    URODP061323, ENSP000002463374I2D: score=3 STRING: ENSP00000246337
    EIF3HO153723, ENSP000002766824I2D: score=2 STRING: ENSP00000276682
    RPS10P467833, ENSP000003472714I2D: score=2 STRING: ENSP00000347271
    RPS15AP622443, ENSP000003186464I2D: score=2 STRING: ENSP00000318646
    RPS8P622413, ENSP000003798884I2D: score=2 STRING: ENSP00000379888
    RPTORQ8N1223, ENSP000003072724I2D: score=2 STRING: ENSP00000307272
    USP3Q9Y6I43, ENSP000003696814I2D: score=2 STRING: ENSP00000369681
    EIF1AXP478133, ENSP000003689274I2D: score=1 STRING: ENSP00000368927
    EIF3LQ9Y2623, ENSP000004168924I2D: score=1 STRING: ENSP00000416892
    EIF5AP632413, ENSP000003367024I2D: score=1 STRING: ENSP00000336702
    HDAC5Q9UQL63, ENSP000002259834I2D: score=1 STRING: ENSP00000225983
    NARSO437763, ENSP000002568544I2D: score=1 STRING: ENSP00000256854
    NCBP1Q091613, ENSP000003642894I2D: score=1 STRING: ENSP00000364289
    SRRM2Q9UQ353, ENSP000003017404I2D: score=1 STRING: ENSP00000301740
    UVRAGQ9P2Y53, ENSP000003484554I2D: score=1 STRING: ENSP00000348455
    EIF3EP602283, ENSP000002208494I2D: score=1 STRING: ENSP00000220849
    MTORP423453, ENSP000003545584I2D: score=3 STRING: ENSP00000354558
    EIF3KQ9UBQ53, ENSP000002483424I2D: score=1 STRING: ENSP00000248342
    RPL18Q070203, ENSP000000847954I2D: score=2 STRING: ENSP00000084795
    RPL22P352682, ENSP000003460884MINT-7947479 STRING: ENSP00000346088
    EIF4EP067303, ENSP000002808924I2D: score=5 STRING: ENSP00000280892
    EIF3MQ7L2H73, ENSP000003199104I2D: score=1 STRING: ENSP00000319910
    UBCP0CG483, ENSP000003448184I2D: score=2 STRING: ENSP00000344818
    EIF6P565373, ENSP000003635594I2D: score=5 STRING: ENSP00000363559
    RPS6P627533, ENSP000003697574I2D: score=5 STRING: ENSP00000369757
    IL2RBP147843, ENSP000002162234I2D: score=2 STRING: ENSP00000216223
    EIF4BP235883, ENSP000002620564I2D: score=2 STRING: ENSP00000262056
    TADA2AO754783, ENSP000002253964I2D: score=1 STRING: ENSP00000225396
    ARPC3O151453, ENSP000002288254I2D: score=4 STRING: ENSP00000228825
    GTF2BQ004033, ENSP000003595314I2D: score=4 STRING: ENSP00000359531
    CDC5LQ994592, ENSP000003605324MINT-7947479 STRING: ENSP00000360532
    BOP1Q141373, ENSP000003041514I2D: score=4 STRING: ENSP00000304151
    RPS11P622803, ENSP000002706254I2D: score=1 STRING: ENSP00000270625
    RPS19P390193, ENSP000002219754I2D: score=1 STRING: ENSP00000221975
    RPS5P467823, ENSP000001965514I2D: score=2 STRING: ENSP00000196551
    BMS1Q146923, ENSP000003636424I2D: score=1 STRING: ENSP00000363642
    EIF4A2Q142402, ENSP000003263814MINT-7947479 STRING: ENSP00000326381
    COPS5Q929052, ENSP000003505124MINT-7947479 STRING: ENSP00000350512
    EIF5BO608412, ENSP000002893714MINT-7947479 STRING: ENSP00000289371
    RPL31P628992, ENSP000003867174MINT-7947479 STRING: ENSP00000386717
    RPLP0P053882, ENSP000003390274MINT-7947479 STRING: ENSP00000339027
    ARFRP1Q137953I2D: score=3 
    OSBPP220593I2D: score=3 
    XPAP230253I2D: score=3 
    ATG9AQ7Z3C63I2D: score=2 
    EML1O004233I2D: score=2 
    HSPH1Q925983I2D: score=2 
    NUDT6P533703I2D: score=2 
    RALAP112333I2D: score=2 
    RPSAP088653I2D: score=2 
    SUPT5HO002673I2D: score=2 
    ACAT1P247523I2D: score=1 
    ACTR3BQ9P1U13I2D: score=1 
    APCP250543I2D: score=1 
    ARPC2O151443I2D: score=1 
    ARPC4P599983I2D: score=1 
    ATG5Q9H1Y03I2D: score=1 
    BRIX1Q8TDN63I2D: score=1 
    CD4P017303I2D: score=1 
    CHD2O146473I2D: score=1 
    CHN2P527573I2D: score=1 
    CNBPP626333I2D: score=1 
    CSO753903I2D: score=1 
    CTSAP106193I2D: score=1 
    DDA1Q9BW613I2D: score=1 
    DDX18Q9NVP13I2D: score=1 
    DDX27Q96GQ73I2D: score=1 
    DDX54Q8TDD13I2D: score=1 
    GABARAPL1Q9H0R83I2D: score=1 
    GBASO753233I2D: score=1 
    GNL2Q138233I2D: score=1 
    GRB7Q144513I2D: score=1 
    GTPBP4Q9BZE43I2D: score=1 
    HSPA9P386463I2D: score=1 
    IKBKEQ141643I2D: score=1 
    KIAA0020Q153973I2D: score=1 
    LIASO437663I2D: score=1 
    LSG1Q9H0893I2D: score=1 
    ME1P481633I2D: score=1 
    MECRQ9BV793I2D: score=1 
    MRTO4Q9UKD23I2D: score=1 
    NOC2LQ9Y3T93I2D: score=1 
    NOC3LQ8WTT23I2D: score=1 
    NOL6Q9H6R43I2D: score=1 
    NRBF2Q96F243I2D: score=1 
    NSA2O954783I2D: score=1 
    NVLO153813I2D: score=1 
    OTUD6BQ8N6M03I2D: score=1 
    OXSMQ9NWU13I2D: score=1 
    PABPC1P119403I2D: score=1 
    PES1O005413I2D: score=1 
    PIK3C2AO004433I2D: score=1 
    POLR1BQ9H9Y63I2D: score=1 
    PPM1GO153553I2D: score=1 
    PRKAG1P546193I2D: score=1 
    PRKAG2Q9UGJ03I2D: score=1 
    PRKAR2AP138613I2D: score=1 
    PSMD14O004873I2D: score=1 
    PYCRLQ53H963I2D: score=1 
    RPA1P276943I2D: score=1 
    RPF1Q9H9Y23I2D: score=1 
    RPF2Q9H7B23I2D: score=1 
    SDAD1Q9NVU73I2D: score=1 
    SLC2A4P146723I2D: score=1 
    SLC30A10Q6XR723I2D: score=1 
    SMEK2Q5MIZ73I2D: score=1 
    USP22Q9UPT93I2D: score=1 
    ZC3H15Q8WU903I2D: score=1 
    ABCF1Q8NE712MINT-7947479
    ABCF3Q9NUQ82MINT-7947479
    ACTL6AO960192MINT-7947479
    ACTR1AP611632MINT-7947479
    ADNPQ9H2P02MINT-7947479
    AHNAKQ096662MINT-7947479
    AKAP8O438232MINT-7947479
    ANAPC1Q9H1A42MINT-7947479
    ANAPC2Q9UJX62MINT-7947479
    ANAPC7Q9UJX32MINT-7947479
    ANLNQ9NQW62MINT-7947479
    ANXA11P509952MINT-7947479
    AP1B1Q105672MINT-7947479
    ARCN1P484442MINT-7947479
    ARGLU1Q9NWB62MINT-7947479
    ARHGEF1Q928882MINT-7947479
    ARHGEF2Q929742MINT-7947479
    ARID1AO144972MINT-7947479
    AURKBQ96GD42MINT-7947479
    BAZ1AQ9NRL22MINT-7947479
    BCAS2O759342MINT-7947479
    BCLAF1Q9NYF82MINT-7947479
    BIDP559572MINT-7947479
    BRD2P254402MINT-7947479
    BRD4O608852MINT-7947479
    BRD7Q9NPI12MINT-7947479
    BRD8Q9H0E92MINT-7947479
    BTAF1O149812MINT-7947479
    BUB1O436832MINT-7947479
    BUB1BO605662MINT-7947479
    BUB3O436842MINT-7947479
    BZW1Q7L1Q62MINT-7947479
    C22orf28Q9Y3I02MINT-7947479
    C7orf13Q8NI282MINT-7947479
    CAPGP401212MINT-7947479
    CAPZA1P529072MINT-7947479
    CARD10Q9BWT72MINT-7947479
    CASC5Q8NG312MINT-7947479
    CCNB1P146352MINT-7947479
    CCT2P783712MINT-7947479
    CCT4P509912MINT-7947479
    CCT5P486432MINT-7947479
    CCT6AP402272MINT-7947479
    CCT7Q998322MINT-7947479
    CCT8P509902MINT-7947479
    CDC16Q130422MINT-7947479
    CDC20Q128342MINT-7947479
    CDC23Q9UJX22MINT-7947479
    CDC27P302602MINT-7947479
    CDC73Q6P1J92MINT-7947479
    CDK9P507502MINT-7947479
    CDKN2AIPQ9NXV62MINT-7947479
    CHD1LQ86WJ12MINT-7947479
    CHD8Q9HCK82MINT-7947479
    CHEK1O147572MINT-7947479
    CKAP5Q140082MINT-7947479
    CLASP1Q7Z4602MINT-7947479
    CLINT1Q146772MINT-7947479
    CNOT10Q9H9A52MINT-7947479
    CNOT3O751752MINT-7947479
    COPAP536212MINT-7947479
    COPB1P536182MINT-7947479
    COPB2P356062MINT-7947479
    COPG1Q9Y6782MINT-7947479
    COPG2Q9UBF22MINT-7947479
    CPSF2Q9P2I02MINT-7947479
    CPSF3Q9UKF62MINT-7947479
    CPSF7Q8N6842MINT-7947479
    CSE1LP550602MINT-7947479
    CSTF3Q129962MINT-7947479
    CTNND1O607162MINT-7947479
    CUL1Q136162MINT-7947479
    CWC15Q9P0132MINT-7947479
    DCTN2Q135612MINT-7947479
    DDB1Q165312MINT-7947479
    DDX17Q928412MINT-7947479
    DDX19AQ9NUU72MINT-7947479
    DDX19BQ9UMR22MINT-7947479
    DDX39AO001482MINT-7947479
    DDX39BQ138382MINT-7947479
    DDX41Q9UJV92MINT-7947479
    DDX42Q86XP32MINT-7947479
    DDX47Q9H0S42MINT-7947479
    DDX5P178442MINT-7947479
    DEPDC7Q96QD52MINT-7947479
    DFNA5O604432MINT-7947479
    DIAPH1O606102MINT-7947479
    DIDO1Q9BTC02MINT-7947479
    DMAP1Q9NPF52MINT-7947479
    DNM1LO004292MINT-7947479
    DNM2P505702MINT-7947479
    DOCK5Q9H7D02MINT-7947479
    DOCK8Q8NF502MINT-7947479
    DRG1Q9Y2952MINT-7947479
    DSPP159242MINT-7947479
    DTYMKP239192MINT-7947479
    DYNC1H1Q142042MINT-7947479
    DYNC1LI1Q9Y6G92MINT-7947479
    DYNC1LI2O432372MINT-7947479
    ECT2Q9H8V32MINT-7947479
    EDC4Q6P2E92MINT-7947479
    EEF1A1P681042MINT-7947479
    EFTUD2Q150292MINT-7947479
    EHD1Q9H4M92MINT-7947479
    EHD4Q9H2232MINT-7947479
    EHMT1Q9H9B12MINT-7947479
    EIF2B4Q9UI102MINT-7947479
    EIF2DP412142MINT-7947479
    EIF4A3P389192MINT-7947479
    EIF4G2P783442MINT-7947479
    ELAVL1Q157172MINT-7947479
    ELF2Q157232MINT-7947479
    ENAHQ8N8S72MINT-7947479
    ENSG00000266714Q96JP22MINT-7947479
    EPB41L3Q9Y2J22MINT-7947479
    EPPK1P581072MINT-7947479
    EPS8L2Q9H6S32MINT-7947479
    ERAL1O756162MINT-7947479
    ERCC1P079922MINT-7947479
    ERCC6LQ2NKX82MINT-7947479
    ETV6P412122MINT-7947479
    EWSR1Q018442MINT-7947479
    EXOC2Q96KP12MINT-7947479
    EXOC4Q96A652MINT-7947479
    EXOC5O004712MINT-7947479
    EXOC7Q9UPT52MINT-7947479
    EXOSC10Q017802MINT-7947479
    FAF1Q9UNN52MINT-7947479
    FAM129BQ96TA12MINT-7947479
    FANCD2Q9BXW92MINT-7947479
    FANCIQ9NVI12MINT-7947479
    FASNP493272MINT-7947479
    FEN1P397482MINT-7947479
    FERMT1Q9BQL62MINT-7947479
    FHOD1Q9Y6132MINT-7947479
    FUSP356372MINT-7947479
    GAPDHP044062MINT-7947479
    GATAD2AQ86YP42MINT-7947479
    GCN1L1Q926162MINT-7947479
    GEMIN4P576782MINT-7947479
    GEMIN6Q8WXD52MINT-7947479
    GMPSP499152MINT-7947479
    GNASP630922MINT-7947479
    GNB3P165202MINT-7947479
    GOLGB1Q147892MINT-7947479
    GPS2Q132272MINT-7947479
    GTF2IP783472MINT-7947479
    GTF3C2Q8WUA42MINT-7947479
    GTF3C5Q9Y5Q82MINT-7947479
    GTPBP1O001782MINT-7947479
    GULP1Q9UBP92MINT-7947479
    HAUS7Q998712MINT-7947479
    HBS1LQ9Y4502MINT-7947479
    HDAC1Q135472MINT-7947479
    HDAC2Q927692MINT-7947479
    HDLBPQ003412MINT-7947479
    HELLSQ9NRZ92MINT-7947479
    HIC2Q96JB32MINT-7947479
    HIP1RO751462MINT-7947479
    HIRAP541982MINT-7947479
    HLTFQ145272MINT-7947479
    HNRNPA2B1P226262MINT-7947479
    HNRNPCP079102MINT-7947479
    HNRNPFP525972MINT-7947479
    HNRNPH1P319432MINT-7947479
    HNRNPKP619782MINT-7947479
    HNRNPMP522722MINT-7947479
    HNRNPUQ008392MINT-7947479
    HSP90AB1P082382MINT-7947479
    HSP90B1P146252MINT-7947479
    HSPA12AO433012MINT-7947479
    HSPA6P170662MINT-7947479
    HSPB1P047922MINT-7947479
    HSPD1P108092MINT-7947479
    HUWE1Q7Z6Z72MINT-7947479
    IKBKAPO951632MINT-7947479
    ILF2Q129052MINT-7947479
    INTS1Q8N2012MINT-7947479
    INTS3Q68E012MINT-7947479
    INTS6Q9UL032MINT-7947479
    INTS8Q75QN22MINT-7947479
    IPO5O004102MINT-7947479
    IPO7O953732MINT-7947479
    IPO9Q96P702MINT-7947479
    IQGAP1P469402MINT-7947479
    ITPK1Q135722MINT-7947479
    KANSL1Q7Z3B32MINT-7947479
    KDM1AO603412MINT-7947479
    KHDRBS1Q076662MINT-7947479
    KIF11P527322MINT-7947479
    KIF21AQ7Z4S62MINT-7947479
    KIF2CQ996612MINT-7947479
    KIF4AO952392MINT-7947479
    KPNA2P522922MINT-7947479
    LAS1LQ9Y4W22MINT-7947479
    LENG9Q96B702MINT-7947479
    LIMS1P480592MINT-7947479
    LMNAP025452MINT-7947479
    LMO7Q8WWI12MINT-7947479
    LRRC1Q9BTT62MINT-7947479
    LRRC40Q9H9A62MINT-7947479
    LRWD1Q9UFC02MINT-7947479
    MAD1L1Q9Y6D92MINT-7947479
    MAGEE2Q8TD902MINT-7947479
    MAP2K4P459852MINT-7947479
    MAP2K7O147332MINT-7947479
    MAP7Q142442MINT-7947479
    MARK2Q7KZI72MINT-7947479
    MATR3P432432MINT-7947479
    MDN1Q9NU222MINT-7947479
    MED12Q930742MINT-7947479
    MED12LQ86YW92MINT-7947479
    MED16Q9Y2X02MINT-7947479
    MED4Q9NPJ62MINT-7947479
    MELKQ146802MINT-7947479
    MPP2Q141682MINT-7947479
    MRE11AP499592MINT-7947479
    MSH2P432462MINT-7947479
    MSH6P527012MINT-7947479
    MTA2O947762MINT-7947479
    MTA3Q9BTC82MINT-7947479
    MVPQ147642MINT-7947479
    MYBBP1AQ9BQG02MINT-7947479
    MYH9P355792MINT-7947479
    MYO15BQ96JP22MINT-7947479
    NACC1Q96RE72MINT-7947479
    NAT10Q9H0A02MINT-7947479
    NBNO609342MINT-7947479
    NCAPD2Q150212MINT-7947479
    NCAPHQ150032MINT-7947479
    NCOR1O753762MINT-7947479
    NDC80O147772MINT-7947479
    NELFBQ8WX922MINT-7947479
    NF1P213592MINT-7947479
    NIPBLQ6KC792MINT-7947479
    NONOQ152332MINT-7947479
    NPM1P067482MINT-7947479
    NRG1Q022972MINT-7947479
    NSFP464592MINT-7947479
    NSUN5Q96P112MINT-7947479
    NUDCQ9Y2662MINT-7947479
    NUDT21O438092MINT-7947479
    NUF2Q9BZD42MINT-7947479
    NUP107P577402MINT-7947479
    NUP155O756942MINT-7947479
    NUP93Q8N1F72MINT-7947479
    ORC2Q134162MINT-7947479
    ORC3Q9UBD52MINT-7947479
    OXSR1O957472MINT-7947479
    PAK4O960132MINT-7947479
    PARP1P098742MINT-7947479
    PARVAQ9NVD72MINT-7947479
    PARVBQ9HBI12MINT-7947479
    PCBP1Q153652MINT-7947479
    PCBP2Q153662MINT-7947479
    PCNTO956132MINT-7947479
    PDLIM7Q9NR122MINT-7947479
    PELOQ9BRX22MINT-7947479
    PFKMP082372MINT-7947479
    PFKPQ018132MINT-7947479
    PHGDHO431752MINT-7947479
    PICALMQ134922MINT-7947479
    PKN2Q165132MINT-7947479
    PLECQ151492MINT-7947479
    PNNQ9H3072MINT-7947479
    POLD1P283402MINT-7947479
    POLR1CO151602MINT-7947479
    POLR3DP054232MINT-7947479
    POLR3EQ9NVU02MINT-7947479
    PPFIA1Q131362MINT-7947479
    PPM1DO152972MINT-7947479
    PPP1CAP621362MINT-7947479
    PPP2R1AP301532MINT-7947479
    PRCCQ927332MINT-7947479
    PRKDCP785272MINT-7947479
    PRPF19Q9UMS42MINT-7947479
    PRPF3O433952MINT-7947479
    PRPF4BQ135232MINT-7947479
    PRPF6O949062MINT-7947479
    PRPF8Q6P2Q92MINT-7947479
    PSMC1P621912MINT-7947479
    PSMC2P359982MINT-7947479
    PSMC3P179802MINT-7947479
    PSMC4P436862MINT-7947479
    PSMC5P621952MINT-7947479
    PSMC6P623332MINT-7947479
    PSMD1Q994602MINT-7947479
    PSMD11O002312MINT-7947479
    PSMD12O002322MINT-7947479
    PSMD13Q9UNM62MINT-7947479
    PSMD3O432422MINT-7947479
    PSTPIP2Q9H9392MINT-7947479
    PTBP1P265992MINT-7947479
    PTBP2Q9UKA92MINT-7947479
    PTBP3O957582MINT-7947479
    PUM1Q146712MINT-7947479
    RACGAP1Q9H0H52MINT-7947479
    RAD18Q9NS912MINT-7947479
    RAD50Q928782MINT-7947479
    RALYQ9UKM92MINT-7947479
    RANBP2P497922MINT-7947479
    RANGAP1P460602MINT-7947479
    RAVER1Q8IY672MINT-7947479
    RBBP5Q152912MINT-7947479
    RBBP7Q165762MINT-7947479
    RBM17Q96I252MINT-7947479
    RBM39Q144982MINT-7947479
    RBM4Q9BWF32MINT-7947479
    RBM45Q8IUH32MINT-7947479
    RBM7Q9Y5802MINT-7947479
    RBMXP381592MINT-7947479
    RCOR1Q9UKL02MINT-7947479
    RFC2P352502MINT-7947479
    RFC3P409382MINT-7947479
    RFC4P352492MINT-7947479
    RFC5P409372MINT-7947479
    RFX1P226702MINT-7947479
    RFX5P483822MINT-7947479
    RIF1Q5UIP02MINT-7947479
    RNF130Q86XS82MINT-7947479
    RNF17Q9BXT82MINT-7947479
    ROCK2O751162MINT-7947479
    RPL13P263732MINT-7947479
    RPL24P837312MINT-7947479
    RPS6KA4O756762MINT-7947479
    RPS6KB2Q9UBS02MINT-7947479
    RUVBL1Q9Y2652MINT-7947479
    RXRBP287022MINT-7947479
    SART1O432902MINT-7947479
    SCAF8Q9UPN62MINT-7947479
    SCRIBQ141602MINT-7947479
    SCYL2Q6P3W72MINT-7947479
    SEC23AQ154362MINT-7947479
    SEC24CP539922MINT-7947479
    SEH1LQ96EE32MINT-7947479
    SENP3Q9H4L42MINT-7947479
    SEPT9Q9UHD82MINT-7947479
    SETXQ7Z3332MINT-7947479
    SF3A1Q154592MINT-7947479
    SF3A2Q154282MINT-7947479
    SF3A3Q128742MINT-7947479
    SF3B1O755332MINT-7947479
    SF3B14Q9Y3B42MINT-7947479
    SF3B2Q134352MINT-7947479
    SF3B3Q153932MINT-7947479
    SFPQP232462MINT-7947479
    SHC1P293532MINT-7947479
    SHROOM3Q8TF722MINT-7947479
    SIN3AQ96ST32MINT-7947479
    SKIV2L2P422852MINT-7947479
    SMARCA5O602642MINT-7947479
    SMARCAD1Q9H4L72MINT-7947479
    SMARCB1Q128242MINT-7947479
    SMARCC1Q929222MINT-7947479
    SMARCC2Q8TAQ22MINT-7947479
    SMARCD1Q96GM52MINT-7947479
    SMARCE1Q969G32MINT-7947479
    SMC1AQ146832MINT-7947479
    SMC2O953472MINT-7947479
    SMC3Q9UQE72MINT-7947479
    SMC4Q9NTJ32MINT-7947479
    SMCHD1A6NHR92MINT-7947479
    SMN1Q166372MINT-7947479
    SMN2Q166372MINT-7947479
    SNAPC4Q5SXM22MINT-7947479
    SNRNP200O756432MINT-7947479
    SNRNP40Q96DI72MINT-7947479
    SNRNP70P086212MINT-7947479
    SNRPAP090122MINT-7947479
    SNRPA1P096612MINT-7947479
    SNRPD1P623142MINT-7947479
    SNRPD3P623182MINT-7947479
    SNRPEP623042MINT-7947479
    SNW1Q135732MINT-7947479
    SNX12Q9UMY42MINT-7947479
    SNX2O607492MINT-7947479
    SOGA2Q9Y4B52MINT-7947479
    SPATA5Q8NB902MINT-7947479
    SPENQ96T582MINT-7947479
    SPTAN1Q138132MINT-7947479
    SPTBN1Q010822MINT-7947479
    SREK1Q8WXA92MINT-7947479
    SRP54P610112MINT-7947479
    SRP68Q9UHB92MINT-7947479
    SRP72O760942MINT-7947479
    SRRM1Q8IYB32MINT-7947479
    SRSF1Q079552MINT-7947479
    SRSF4Q081702MINT-7947479
    SRSF7Q166292MINT-7947479
    SSUH2Q9Y2M22MINT-7947479
    STAB1Q9NY152MINT-7947479
    STAG2Q8N3U42MINT-7947479
    STAT3P407632MINT-7947479
    STK24Q9Y6E02MINT-7947479
    SUGT1Q9Y2Z02MINT-7947479
    SUMO1P631652MINT-7947479
    SYMPKQ927972MINT-7947479
    TAF15Q928042MINT-7947479
    TAF5LO755292MINT-7947479
    TANC2Q9HCD62MINT-7947479
    TARDBPQ131482MINT-7947479
    TBL1XR1Q9BZK72MINT-7947479
    THAP1Q9NVV92MINT-7947479
    THRAP3Q9Y2W12MINT-7947479
    TIAL1Q010852MINT-7947479
    TLN1Q9Y4902MINT-7947479
    TLN2Q9Y4G62MINT-7947479
    TMOD3Q9NYL92MINT-7947479
    TMPOP421662MINT-7947479
    TNFAIP2Q031692MINT-7947479
    TNKS1BP1Q9C0C22MINT-7947479
    TNPO1Q929732MINT-7947479
    TPRP122702MINT-7947479
    TPX2Q9ULW02MINT-7947479
    TRAP1Q129312MINT-7947479
    TRIM21P194742MINT-7947479
    TRIM28Q132632MINT-7947479
    TRIP13Q156452MINT-7947479
    TRMT1LQ7Z2T52MINT-7947479
    TRRAPQ9Y4A52MINT-7947479
    TRUB1Q8WWH52MINT-7947479
    TSG101Q998162MINT-7947479
    TUBA1CQ9BQE32MINT-7947479
    TUBA4AP683662MINT-7947479
    TUBBP074372MINT-7947479
    TUBB4BP683712MINT-7947479
    TUBG1P232582MINT-7947479
    TUBGCP2Q9BSJ22MINT-7947479
    TUBGCP3Q96CW52MINT-7947479
    TUBGCP4Q9UGJ12MINT-7947479
    TWF1Q127922MINT-7947479
    U2AF1Q010812MINT-7947479
    U2AF2P263682MINT-7947479
    U2SURPO150422MINT-7947479
    UBE2MP610812MINT-7947479
    UBE2NP610882MINT-7947479
    UBE2SQ167632MINT-7947479
    UBL4AP114412MINT-7947479
    UBN1Q9NPG32MINT-7947479
    UCHL5Q9Y5K52MINT-7947479
    UMPSP111722MINT-7947479
    UNC45AQ9H3U12MINT-7947479
    USO1O607632MINT-7947479
    USP10Q146942MINT-7947479
    USP24Q9UPU52MINT-7947479
    USP39Q53GS92MINT-7947479
    VIMP086702MINT-7947479
    VPS33AQ96AX12MINT-7947479
    VPS33BQ9H2672MINT-7947479
    VPS36Q86VN12MINT-7947479
    VPS51Q9UID32MINT-7947479
    WDR18Q9BV382MINT-7947479
    WDR33Q9C0J82MINT-7947479
    WRNIP1Q96S552MINT-7947479
    XPO5Q9HAV42MINT-7947479
    XRN2Q9H0D62MINT-7947479
    YEATS4O956192MINT-7947479
    YLPM1P497502MINT-7947479
    YWHAEP622582MINT-7947479
    ZBTB7CA1YPR02MINT-7947479
    ZC3HC1Q86WB02MINT-7947479
    ZNF638Q149662MINT-7947479
    LOC255308ENSP000003230634MINT-7947479 STRING: ENSP00000323063
    EIF4HENSP000002657534STRING: ENSP00000265753
    FAUENSP000002792594STRING: ENSP00000279259
    RPL11ENSP000003636764STRING: ENSP00000363676
    RPL12ENSP000003547394STRING: ENSP00000354739
    RPL15ENSP000003093344STRING: ENSP00000309334
    RPL18AENSP000002222474STRING: ENSP00000222247
    RPL23ENSP000003778654STRING: ENSP00000377865
    RPL27ENSP000002537884STRING: ENSP00000253788
    RPL27AENSP000003460154STRING: ENSP00000346015
    RPL29ENSP000002941894STRING: ENSP00000294189
    RPL3ENSP000003460014STRING: ENSP00000346001
    RPL30ENSP000002870384STRING: ENSP00000287038
    RPL34ENSP000003781604STRING: ENSP00000378160
    RPL35ENSP000002594694STRING: ENSP00000259469
    RPL35AENSP000003933934STRING: ENSP00000393393
    RPL36ENSP000002525434STRING: ENSP00000252543
    RPL37ENSP000002742424STRING: ENSP00000274242
    RPL37AENSP000004180824STRING: ENSP00000418082
    RPL38ENSP000003098304STRING: ENSP00000309830
    RPL3LENSP000002686614STRING: ENSP00000268661
    RPL4ENSP000003114304STRING: ENSP00000311430
    RPL5ENSP000003593454STRING: ENSP00000359345
    RPL6ENSP000002027734STRING: ENSP00000202773
    RPL7AENSP000003610764STRING: ENSP00000361076
    RPL8ENSP000002625844STRING: ENSP00000262584
    RPL9ENSP000003460224STRING: ENSP00000346022
    RPLP1ENSP000003460374STRING: ENSP00000346037
    RPLP2ENSP000003224194STRING: ENSP00000322419
    RPS14ENSP000003110284STRING: ENSP00000311028
    RPS16ENSP000002514534STRING: ENSP00000251453
    RPS17ENSP000003460454STRING: ENSP00000346045
    RPS20ENSP000000095894STRING: ENSP00000009589
    RPS21ENSP000003244384STRING: ENSP00000324438
    RPS23ENSP000002966744STRING: ENSP00000296674
    RPS24ENSP000004143214STRING: ENSP00000414321
    RPS29ENSP000003793394STRING: ENSP00000379339
    RPS3ENSP000002785724STRING: ENSP00000278572
    RPS9ENSP000003028964STRING: ENSP00000302896
    UBA52ENSP000003881074STRING: ENSP00000388107
    RPL28ENSP000004014504STRING: ENSP00000401450
    EIF3DENSP000002161904STRING: ENSP00000216190
    DKC1ENSP000003585634STRING: ENSP00000358563
    PWP2ENSP000002915764STRING: ENSP00000291576
    ABCE1ENSP000002965774STRING: ENSP00000296577
    KNCNENSP000003796074STRING: ENSP00000379607
    TRMT112ENSP000003094334STRING: ENSP00000309433
    COPS7BENSP000002729954STRING: ENSP00000272995
    EIF1BENSP000002329054STRING: ENSP00000232905
    NLE1ENSP000004135724STRING: ENSP00000413572
    EIF1AYENSP000003547224STRING: ENSP00000354722
    IMPACTENSP000002842024STRING: ENSP00000284202
    EIF4E1BENSP000003237144STRING: ENSP00000323714
    ABT1ENSP000002748494STRING: ENSP00000274849
    LOC727967ENSP000003666294STRING: ENSP00000366629
    COPS7AENSP000002292514STRING: ENSP00000229251
    CSNK2A2ENSP000002625064STRING: ENSP00000262506
    NAA11ENSP000002867944STRING: ENSP00000286794
    CSNK2A1ENSP000002172444STRING: ENSP00000217244
    About this table

    Gene Ontology (GO): 5 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006412translation TAS--
    GO:0006413translational initiation TAS--
    GO:0006446regulation of translational initiation IDA8995410
    GO:0010467gene expression TAS--
    GO:0044267cellular protein metabolic process TAS--


    EIF3B for ontologies           About GeneDecksing



    Drugs & Compounds
    for EIF3B gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for EIF3B
    Search CenterWatch for drugs/clinical trials and news about EIF3B 

    Transcripts
    for EIF3B gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for EIF3B gene (2 alternative transcripts): 
    NM_001037283.1  NM_003751.3  

    Unigene Cluster for EIF3B:

    Eukaryotic translation initiation factor 3, subunit B
    Hs.371001  [show with all ESTs]
    Unigene Representative Sequence: AB209381
    12 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000431643 ENST00000360876(uc003slx.3 uc003sly.3 uc003slz.1)
    ENST00000413917 ENST00000397011(uc003sma.3) ENST00000463229 ENST00000463026
    ENST00000468250 ENST00000466199 ENST00000475415 ENST00000468611(uc003smb.3)
    ENST00000465670 ENST00000494658

    miRNA
    Products:             		 OriGene 3'-UTR Clone (see all 2): EIF3B
    Browse OriGene MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat EIF3B
    6 QIAGEN miScript miRNA Assays for microRNAs that regulate EIF3B:
    hsa-miR-3140-3p hsa-miR-124 hsa-miR-198 hsa-miR-525-5p hsa-miR-506 hsa-miR-520a-5p
    SwitchGear 3'UTR luciferase reporter plasmid: EIF3B 3' UTR sequence
    Inhib. RNA
    Products:             		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for EIF3B (see all 4)
    OriGene shRNA RFP: EIF3B
    OriGene siRNA: EIF3B
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat EIF3B
    Clone
    Products:             		 OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for EIF3B (see all 4)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for EIF3B (see all 3)
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector (see all 2): EIF3B (NM_003751)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for EIF3B
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat EIF3B 
    Primer
    Products:            		 OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for EIF3B
    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat EIF3B
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat EIF3B
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat EIF3B

    Additional cDNA sequence: 

    AB209381.1 AK127885.1 AK300967.1 AK302058.1 BC001173.1 BC009986.1 BC110865.1 U62583.1 
    U78525.1 

    24/35 DOTS entries (see all 35):

    DT.100834695  DT.97798019  DT.100759692  DT.95173385  DT.100834690  DT.454061  DT.100730058  DT.429116 
    DT.92462641  DT.97786597  DT.203336  DT.70104982  DT.102836765  DT.100039603  DT.95305235  DT.95148198 
    DT.97864515  DT.121124337  DT.95313948  DT.100834693  DT.121124353  DT.100033517  DT.100834684  DT.100834692 

    24/758 AceView cDNA sequences (see all 758):

    AW613698 BQ221471 BM560380 BF108826 BQ709516 AW015861 AI825123 CB115033 
    AI204368 BC001173 BQ669015 CA434118 BP368238 BU175745 CD673946 BU856686 
    AI699769 CR603939 AI336324 BQ643260 AU124102 AW473838 BM904776 BU956074 

    GeneLoc Exon Structure

    5/18 Alternative Splicing Database (ASD) splice patterns (SP) for EIF3B (see all 18)    About this scheme

    ExUns: 1 ^ 2 ^ 3a · 3b · 3c ^ 4a · 4b ^ 5a · 5b ^ 6a · 6b ^ 7a · 7b ^ 8a · 8b ^ 9a · 9b · 9c ^ 10 ^ 11a · 11b ^ 12a · 12b ^ 13 ^ 14 ^ 15a ·
    SP1:                                                                                            -                             -           -     -               
    SP2:                                                                                            -                             -           -     -               
    SP3:                                                                                            -                             -           -     -               
    SP4:                                                                                            -                             -           -     -               
    SP5:        -     -     -     -                                                                                                                                 

    ExUns: 15b · 15c ^ 16 ^ 17a · 17b ^ 18 ^ 19a · 19b · 19c ^ 20a · 20b ^ 21 ^ 22a · 22b ^ 23a · 23b ^ 24a · 24b · 24c
    SP1:        -           -                 -                                         -     -           -               
    SP2:        -           -                 -                                         -                                 
    SP3:        -           -                 -                                         -     -                           
    SP4:        -           -                 -                                         -     -                           
    SP5:                                                                                                                  


    ECgene alternative splicing isoforms for EIF3B

    Expression
    for EIF3B gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    EIF3B expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: GAAATAAAAG

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image
    See EIF3B Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for EIF3B

    SOURCE GeneReport for Unigene cluster: Hs.371001
        SABiosciences Custom PCR Arrays for EIF3B
    Primer
    Products:    		 OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for EIF3B
    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat EIF3B
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat EIF3B
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat EIF3B
    In Situ
    Assay Products:     
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for EIF3B

    Orthologs
    for EIF3B gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of eukaryotes.

    Orthologs for EIF3B gene from 9/36 species (see all 36)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    chicken
    (Gallus gallus)    		 Aves EIF3B1 eukaryotic translation initiation factor 3, subunit more 79.62(n)
    91.02(a)    		   769783  XM_003642142.1  XP_003642190.1 
    lizard
    (Anolis carolinensis)    		 Reptilia --
    		 --
    		 81(a)
    		 1 ↔ 1
    		 GL343340.1(42357-51899)
    African clawed frog
    (Xenopus laevis)    		 Amphibia Xl.260732 Xenopus laevis transcribed sequence with moderate similarity more 77.37(n)    48055327 
    zebrafish
    (Danio rerio)    		 Actinopterygii wufc17c012 wufc17c01 82.82(n)   324028  CA787533.1 
    fruit fly
    (Drosophila melanogaster)    		 Insecta eIF3-S91 CG4878-PA 58.47(n)
    53.76(a)    		   36981  NM_137384.3  NP_611228.1 
    worm
    (Caenorhabditis elegans)    		 Secernentea eif-3.B1 Protein EIF-3.B 46.13(n)
    36.6(a)    		   175138  NM_001027298.3  NP_001022469.1 
    baker's yeast
    (Saccharomyces cerevisiae)    		 Saccharomycetes PRT1(YOR361C)4
    PRT11    		 eIF3b subunit of the core complex of translation initiation more4
    Prt1p1    		 47.92(n)1
    34.28(a)1    		   15(1017652-1015361)4
    8545431, 4  NP_015006.31  NP_015006.14 
    thale cress
    (Arabidopsis thaliana)    		 eudicotyledons TIF3B11 translation initiation factor 3 subunit B 53.14(n)
    43.23(a)    		   832826  NM_001036877.2  NP_001031954.1 
    rice
    (Oryza sativa)    		 Liliopsida Os.48992 Oryza sativa (japonica cultivar-group) cDNA clone0 more 70.36(n)    AK110143.1 


    ENSEMBL Gene Tree for EIF3B (if available)
    TreeFam Gene Tree for EIF3B (if available) 

    Paralogs
    for EIF3B gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    		  --

    Genomic Variants
    for EIF3B gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/761 NCBI SNPs in EIF3B are shown (see all 761)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 7 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs77959371,2
    		C,--2392502(+) cttatC/Tgtaca 2 -- us2k10--------
    rs1866445271,2
    		--2392544(+) ACCTGC/TCCAAA 2 -- us2k10--------
    rs1911089171,2
    		--2392571(+) CATGAC/TGAGGA 2 -- us2k10--------
    rs1405732621,2
    		--2392678(+) AGTCCC/TGGCAC 2 -- us2k10--------
    rs749343721,2
    		F,--2392748(+) ACACAG/ATGAGA 2 -- us2k11Minor allele frequency- A:0.03NA 120
    rs1457357701,2
    		--2392785(+) TGGGCA/GCGGTG 2 -- us2k10--------
    rs624441621,2
    		C,--2392860(+) GCATAT/CTAAAA 2 -- us2k12Minor allele frequency- C:0.08NA 122
    rs1825669971,2
    		--2392876(+) AGGCCC/GTGCGC 2 -- us2k10--------
    rs1418556821,2
    		--2392881(+) CTGCGC/GGGTGG 2 -- us2k10--------
    rs77929341,2
    		C,F,--2393016(+) ACCCTG/ATCTCT 2 -- us2k112Minor allele frequency- A:0.24NA WA CSA EA 374

    HapMap Linkage Disequilibrium report for EIF3B (2393721 - 2420380 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 9 variations for EIF3B
         2 CNVs: 69768 99846
         7 Indels: 94341 12902 81845 69769 12901 28608 12900

    SABiosciences Cancer Mutation PCR Assays
    Search QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing EIF3B
    DNA2.0 Custom Variant and Variant Library Synthesis for EIF3B

    Disorders / Diseases
    for EIF3B gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    EIF3B for disorders           About GeneDecksing

    OMIM gene information: 603917    OMIM disorders: --

    4 diseases for EIF3B:    About MalaCards
    mouth disease    tetralogy of fallot    melanoma    malaria


    Export disorders for EIF3B gene to outside databases

    Publications
    for EIF3B gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for EIF3B gene, integrated from 9 sources (see all 73):
    (articles sorted by number of sources associating them with EIF3B)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. The human homologue of the yeast Prt1 protein is an integral part of the eukaryotic initiation factor 3 complex and interacts with p170. (PubMed id 8995410)1, 2, 3, 9 Methot N.... Sonenberg N. (1997)
    2. Molecular interaction between human tumor marker protein p150, the largest subunit of eIF3, and intermediate filament protein K7. (PubMed id 11169732)1, 2, 9 Lin L.... Burger M.M. (2001)
    3. Biochemical characterization of mammalian translation initiation factor 3 (eIF3). Molecular cloning reveals that p110 subunit is the mammalian homologue of Saccharomyces cerevisiae protein Prt1. (PubMed id 9388245)1, 2, 9 Chaudhuri J.... Maitra U. (1997)
    4. Mass spectrometry reveals modularity and a complete subunit interaction map of the eukaryotic translation factor eIF3. (PubMed id 18599441)1, 2 Zhou M....Robinson C.V. (2008)
    5. Reconstitution reveals the functional core of mammalian eIF3. (PubMed id 17581632)1, 2 Masutani M.... Imataka H. (2007)
    6. Structural characterization of the human eukaryotic initiation factor 3 protein complex by mass spectrometry. (PubMed id 17322308)1, 2 Damoc E....Leary J.A. (2007)
    7. Structure of eIF3b RNA recognition motif and its interaction with eIF3j: structural insights into the recruitment of eIF3b to the 40 S ribosomal subunit. (PubMed id 17190833)1, 2 ElAntak L.... Lukavsky P.J. (2007)
    8. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)1, 2 Olsen J.V....Mann M. (2006)
    9. mTOR and S6K1 mediate assembly of the translation preinitiation complex through dynamic protein interchange and ordered phosphorylation events. (PubMed id 16286006)1, 2 Holz M.K.... Blenis J. (2005)
    10. The j-subunit of human translation initiation factor eIF3 is required for the stable binding of eIF3 and its subcomplexes to 40 S ribosomal subunits in vitro. (PubMed id 14688252)1, 2 Fraser C.S....Hershey J.W. (2004)

    External Searches for EIF3B gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
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    Genome Databases showing EIF3B gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 8662 HGNC: 3280 AceView: EIF3S9 Ensembl:ENSG00000106263 euGenes: HUgn8662
    ECgene: EIF3B Kegg: 8662 H-InvDB: EIF3B

    Other Databases showing EIF3B gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing EIF3B gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for EIF3B Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for EIF3B gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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