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EIF3B Gene

protein-coding   GIFtS: 59
GCID: GC07P002362

Eukaryotic Translation Initiation Factor 3, Subunit B

(Previous names: eukaryotic translation initiation factor 3, subunit 9 eta,...)
(Previous symbol: EIF3S9)
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Eukaryotic Translation Initiation Factor 3, Subunit B1 2     hPrt12 3
EIF3S91 2 3 5     PRT12 5
Eukaryotic Translation Initiation Factor 3, Subunit 9 Eta, 116kDa1 2     EIF3-ETA2
Eukaryotic Translation Initiation Factor 3 Subunit 92 3     EIF3-P1102
Prt1 Homolog2 3     EIF3-P1162
eIF-3-eta2 3     Eukaryotic Translation Initiation Factor 3 Subunit B2
EIF3 P1102 3     Eukaryotic Translation Initiation Factor 3, Subunit 9 (Eta, 116kD)2
EIF3 P1162 3     eIF3b3

External Ids:    HGNC: 32801   Entrez Gene: 86622   Ensembl: ENSG000001062637   OMIM: 6039175   UniProtKB: P558843   

Export aliases for EIF3B gene to outside databases


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for EIF3B Gene:
EIF3B (eukaryotic translation initiation factor 3, subunit B) is a protein-coding gene. GO annotations related to this gene include protein complex scaffold and nucleotide binding.

UniProtKB/Swiss-Prot: EIF3B_HUMAN, P55884
Function: Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for
several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and
facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S preinitiation
complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG
recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal
complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation

Gene Wiki entry for EIF3B Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000007.13  NC_018918.2  NT_007819.18  
Regulatory elements:
   Regulatory transcription factor binding sites in the EIF3B gene promoter:
         Max1   Pax-5   NF-E2 p45   Egr-4   AREB6   Pax-4a   NF-E2   ATF   ATF6   c-Myc   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 11): EIF3B promoter sequence
   Search Chromatin IP Primers for EIF3B

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat EIF3B


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 7p22.3   Ensembl cytogenetic band:  7p22.3   HGNC cytogenetic band: 7p22

EIF3B Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
EIF3B gene location

GeneLoc information about chromosome 7         GeneLoc Exon Structure

GeneLoc location for GC07P002362:  view genomic region     (about GC identifiers)

Start:
2,393,721 bp from pter      End:
2,420,380 bp from pter
Size:
26,660 bases      Orientation:
plus strand

1 alternative location:
Chr7+,CRA_TCAG 2,442,541-2,468,274     

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: EIF3B_HUMAN, P55884 (See protein sequence)
Recommended Name: Eukaryotic translation initiation factor 3 subunit B  
Size: 814 amino acids; 92482 Da
Subunit: Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is composed of 13
subunits: EIF3A, EIF3B, EIF3C, EIF3D, EIF3E, EIF3F, EIF3G, EIF3H, EIF3I, EIF3J, EIF3K, EIF3L and EIF3M. The eIF-3
complex appears to include 3 stable modules: module A is composed of EIF3A, EIF3B, EIF3G and EIF3I; module B is
composed of EIF3F, EIF3H, and EIF3M; and module C is composed of EIF3C, EIF3D, EIF3E, EIF3K and EIF3L. EIF3C of
module C binds EIF3B of module A and EIF3H of module B, thereby linking the three modules. EIF3J is a labile
subunit that binds to the eIF-3 complex via EIF3B. The eIF-3 complex interacts with RPS6KB1 under conditions of
nutrient depletion. Mitogenic stimulation leads to binding and activation of a complex composed of MTOR and
RPTOR, leading to phosphorylation and release of RPS6KB1 and binding of EIF4B to eIF-3. Also interacts with UPF2
Mass spectrometry: Mass=93093.7; Method=Unknown; Range=1-814; Source=PubMed:17322308;
Mass spectrometry: Mass=92561; Mass_error=43.5; Method=MALDI; Range=1-814; Source=PubMed:18599441;
2 PDB 3D structures from and Proteopedia for EIF3B:
2KRB (3D)        2NLW (3D)    
Secondary accessions: A4D208 Q2NL77 Q9UMF9
Alternative splicing: 2 isoforms:  P55884-1   P55884-2   

Explore the universe of human proteins at neXtProt for EIF3B: NX_P55884

Explore proteomics data for EIF3B at MOPED

Post-translational modifications: 

  • Phosphorylated. Phosphorylation is enhanced upon serum stimulation1
  • Ubiquitination2 at Lys209, Lys230, Lys257, Lys288, Lys324, Lys345, Lys364, Lys516, Lys535, Lys552,
                                 Lys604, Lys718, Lys729, Lys744, Lys762
  • Modification sites at PhosphoSitePlus

  • See EIF3B Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001032360.1  NP_003742.2  

    ENSEMBL proteins: 
     ENSP00000408062   ENSP00000354125   ENSP00000407785   ENSP00000380206  
    Reactome Protein details: P55884

    EIF3B Human Recombinant Protein Products:

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    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for EIF3B

     
    Search eBioscience for Proteins for EIF3B 

     
    antibodies-online proteins for EIF3B 

     
    antibodies-online peptides for EIF3B

    EIF3B Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
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    ThermoFisher Antibodies for EIF3B
    antibodies-online antibodies for EIF3B (17 products) 

    EIF3B Assay Products:

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    Cloud-Clone Corp. ELISAs for EIF3B
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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    RBM: RNA binding motif (RRM) containing

    5 InterPro protein domains:
     IPR013979 TIF_beta_prop-like
     IPR000504 RRM_dom
     IPR012677 Nucleotide-bd_a/b_plait
     IPR015943 WD40/YVTN_repeat-like_dom
     IPR011400 EIF3B

    Graphical View of Domain Structure for InterPro Entry P55884

    ProtoNet protein and cluster: P55884

    2 Blocks protein domains:
    IPB000504 RNA-binding region RNP-1 (RNA recognition motif)
    IPB013979 Eukaryotic translation initiation factor 2A


    UniProtKB/Swiss-Prot: EIF3B_HUMAN, P55884
    Domain: The RRM domain mediates interaction with EIF3J
    Similarity: Belongs to the eIF-3 subunit B family
    Similarity: Contains 1 RRM (RNA recognition motif) domain
    Similarity: Contains 5 WD repeats


    Find genes that share domains with EIF3B           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: EIF3B_HUMAN, P55884
    Function: Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for
    several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and
    facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S preinitiation
    complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG
    recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal
    complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation

         Gene Ontology (GO): Selected molecular function terms (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000166nucleotide binding IEA--
    GO:0003676nucleic acid binding ----
    GO:0003723RNA binding ----
    GO:0003743contributes to translation initiation factor activity IDA17581632
    GO:0005515protein binding IPI11169732
         
    Find genes that share ontologies with EIF3B           About GenesLikeMe


    Phenotypes:
         5 GenomeRNAi human phenotypes for EIF3B:
     Decreased G3BP1 protein expres  Decreased viability of wild-ty  Increased cell death in HCT116  Nuclear 60S biogenesis defects 
     Nucleolar pre-40S maturation d 

    Animal Models:
       genOway: Develop your customized and physiologically relevant rodent model for EIF3B

    miRNA
    Products:
        
    miRTarBase miRNAs that target EIF3B:
    hsa-mir-151a-3p (MIRT043600), hsa-mir-92a-3p (MIRT049064), hsa-mir-615-3p (MIRT039779), hsa-mir-877-3p (MIRT036964), hsa-mir-222-3p (MIRT046746), hsa-mir-423-3p (MIRT042468), hsa-mir-324-3p (MIRT042887), hsa-mir-124-3p (MIRT022932)

    Block miRNA regulation of human, mouse, rat EIF3B using miScript Target Protectors
    6 qRT-PCR Assays for microRNAs that regulate EIF3B:
    hsa-miR-3140-3p hsa-miR-124 hsa-miR-198 hsa-miR-525-5p hsa-miR-506 hsa-miR-520a-5p
    SwitchGear 3'UTR luciferase reporter plasmidEIF3B 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for EIF3B
    Predesigned siRNA for gene silencing in human, mouse, rat EIF3B

    Gene Editing
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    Clone
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    OriGene clones in human, mouse for EIF3B (see all 12)
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    GenScript: all cDNA clones in your preferred vector (see all 2): EIF3B (NM_003751)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for EIF3B
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat EIF3B

    Cell Line
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    EIF3B_HUMAN, P55884: Cytoplasm (By similarity)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol4
    nucleus3

    Gene Ontology (GO): 5 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005829cytosol TAS--
    GO:0005852eukaryotic translation initiation factor 3 complex IDA17322308
    GO:0016282eukaryotic 43S preinitiation complex IEA--
    GO:0033290eukaryotic 48S preinitiation complex IEA--
    GO:0070062extracellular vesicular exosome IDA--

    Find genes that share ontologies with EIF3B           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for EIF3B About   (see all 6)  
    See pathways by source

    SuperPathContained pathways About
    1Influenza Viral RNA Transcription and Replication
    L13a-mediated translational silencing of Ceruloplasmin expression0.94
    Cap-dependent Translation Initiation0.89
    Formation of a pool of free 40S subunits0.94
    Eukaryotic Translation Initiation0.89
    GTP hydrolysis and joining of the 60S ribosomal subunit0.93
    Translation0.82
    2Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S
    Translation initiation complex formation0.91
    Formation of the ternary complex, and subsequently, the 43S complex0.91
    Ribosomal scanning and start codon recognition0.91
    Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S0.90
    3Gene Expression
    Gene Expression0.40
    4Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein
    Metabolism of proteins0.30
    5Translation Factors
    Translation Factors


    Find genes that share SuperPaths with EIF3B           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    2 Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for EIF3B
        eIF2 Pathway
    mTOR Pathway

    1 BioSystems Pathway for EIF3B
        Translation Factors

    Selected Reactome Pathways for EIF3B (see all 6)
        Formation of the ternary complex, and subsequently, the 43S complex
    L13a-mediated translational silencing of Ceruloplasmin expression
    GTP hydrolysis and joining of the 60S ribosomal subunit
    Ribosomal scanning and start codon recognition
    Formation of a pool of free 40S subunits


    1 Kegg Pathway  (Kegg details for EIF3B):
        RNA transport

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for EIF3B
    Interactions:

        Search GeneGlobe Interaction Network for EIF3B

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for EIF3B (P558841, 2, 3 ENSP000003541254) via UniProtKB, MINT, STRING, and/or I2D (see all 843) (see top 5)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    HIST1H4AP628053I2D: score=1 
    HIST1H4BP628053I2D: score=1 
    HIST1H4CP628053I2D: score=1 
    HIST1H4DP628053I2D: score=1 
    HIST1H4EP628053I2D: score=1 
    HIST1H4FP628053I2D: score=1 
    HIST1H4HP628053I2D: score=1 
    HIST1H4IP628053I2D: score=1 
    HIST1H4JP628053I2D: score=1 
    HIST1H4KP628053I2D: score=1 
    HIST1H4LP628053I2D: score=1 
    HIST2H4AP628053I2D: score=1 
    HIST2H4BP628053I2D: score=1 
    HIST4H4P628053I2D: score=1 
    EIF3FO003031, 2, 3, ENSP000003100404EBI-366696,EBI-711990 MINT-6948891 MINT-6948874 I2D: score=2 STRING: ENSP00000310040
    EIF3IQ133471, 2, 3, ENSP000003626884EBI-366696,EBI-354047 MINT-7947479 I2D: score=13 STRING: ENSP00000362688
    EIF3CQ996132, 3, ENSP000003326044MINT-6948891 I2D: score=6 STRING: ENSP00000332604
    EIF4G1Q046372, 3, ENSP000003168794MINT-8409716 I2D: score=3 STRING: ENSP00000316879
    PLRG1O436602, 3, ENSP000003031914MINT-7947479 I2D: score=3 STRING: ENSP00000303191
    UPF2Q9HAU52, 3, ENSP000003487084MINT-7947479 I2D: score=1 STRING: ENSP00000348708
    DNAJA1P316892, 3MINT-7947479 I2D: score=2 
    ETF1P624952, 3MINT-7947479 I2D: score=2 
    HSPA8P111422, 3MINT-7947479 I2D: score=2 
    RUVBL2Q9Y2302, 3MINT-7947479 I2D: score=2 
    ACTBP607092, 3MINT-7947479 I2D: score=1 
    ACTR2P611602, 3MINT-7947479 I2D: score=1 
    CCT3P493682, 3MINT-7947479 I2D: score=1 
    HSP90AA1P079002, 3MINT-7947479 I2D: score=1 
    HSPA5P110212, 3MINT-7947479 I2D: score=1 
    PLK1P533502, 3MINT-7947479 I2D: score=1 
    PSMD2Q132002, 3MINT-7947479 I2D: score=1 
    RBBP4Q090282, 3MINT-7947479 I2D: score=1 
    SUPT16HQ9Y5B92, 3MINT-7947479 I2D: score=1 
    TCP1P179872, 3MINT-7947479 I2D: score=1 
    UBA5Q9GZZ92, 3MINT-7947479 I2D: score=1 
    EIF3AQ141521, 2, 3, ENSP000003581404EBI-366696,EBI-366617 MINT-6948891 I2D: score=17 STRING: ENSP00000358140
    EIF3GO758211, 2, 3, ENSP000002531084EBI-366696,EBI-366632 MINT-7947479 I2D: score=11 STRING: ENSP00000253108
    DDX3XO005711, 2, 3, ENSP000003828404EBI-366696,EBI-353779 MINT-7947479 I2D: score=1 STRING: ENSP00000382840
    EIF3JO758221, 3, ENSP000002618684EBI-366696,EBI-366647 I2D: score=4 STRING: ENSP00000261868
    EIF4A1P608422, 3, ENSP000002938314MINT-7947479 I2D: score=3 STRING: ENSP00000293831
    UPF1Q929002, 3, ENSP000002628034MINT-7947479 I2D: score=1 STRING: ENSP00000262803
    KPNB1Q149742, 3, ENSP000002901584MINT-7947479 I2D: score=3 STRING: ENSP00000290158
    EIF2S3P410912, 3, ENSP000002530394MINT-7947479 I2D: score=3 STRING: ENSP00000253039
    DDX6P261962, 3, ENSP000002640184MINT-7947479 I2D: score=1 STRING: ENSP00000264018
    RPS13P622772, 3, ENSP000002281404MINT-7947479 I2D: score=2 STRING: ENSP00000228140
    EIF1P415673, ENSP000004194494I2D: score=7 STRING: ENSP00000419449
    EIF5P550103, ENSP000002165544I2D: score=7 STRING: ENSP00000216554
    ADSLP305663, ENSP000002161944I2D: score=4 STRING: ENSP00000216194
    EIF2S1P051983, ENSP000002563834I2D: score=4 STRING: ENSP00000256383
    GNB2L1P632443, ENSP000003660134I2D: score=4 STRING: ENSP00000366013
    HAT1O149293, ENSP000002641084I2D: score=4 STRING: ENSP00000264108
    CWC22Q9HCG83, ENSP000003870064I2D: score=3 STRING: ENSP00000387006
    EIF2S2P200423, ENSP000003641194I2D: score=3 STRING: ENSP00000364119
    NAA10P412273, ENSP000004177634I2D: score=3 STRING: ENSP00000417763
    NHP2L1P557693, ENSP000002159564I2D: score=3 STRING: ENSP00000215956
    POLE2P562823, ENSP000002163674I2D: score=3 STRING: ENSP00000216367
    RPS6KB1P234433, ENSP000002255774I2D: score=3 STRING: ENSP00000225577
    URODP061323, ENSP000002463374I2D: score=3 STRING: ENSP00000246337
    EIF3HO153723, ENSP000002766824I2D: score=2 STRING: ENSP00000276682
    RPS10P467833, ENSP000003472714I2D: score=2 STRING: ENSP00000347271
    RPS15AP622443, ENSP000003186464I2D: score=2 STRING: ENSP00000318646
    RPS8P622413, ENSP000003798884I2D: score=2 STRING: ENSP00000379888
    RPTORQ8N1223, ENSP000003072724I2D: score=2 STRING: ENSP00000307272
    USP3Q9Y6I43, ENSP000003696814I2D: score=2 STRING: ENSP00000369681
    EIF1AXP478133, ENSP000003689274I2D: score=1 STRING: ENSP00000368927
    EIF3LQ9Y2623, ENSP000004168924I2D: score=1 STRING: ENSP00000416892
    EIF5AP632413, ENSP000003367024I2D: score=1 STRING: ENSP00000336702
    HDAC5Q9UQL63, ENSP000002259834I2D: score=1 STRING: ENSP00000225983
    NARSO437763, ENSP000002568544I2D: score=1 STRING: ENSP00000256854
    NCBP1Q091613, ENSP000003642894I2D: score=1 STRING: ENSP00000364289
    SRRM2Q9UQ353, ENSP000003017404I2D: score=1 STRING: ENSP00000301740
    UVRAGQ9P2Y53, ENSP000003484554I2D: score=1 STRING: ENSP00000348455
    MTORP423453, ENSP000003545584I2D: score=3 STRING: ENSP00000354558
    RPL18Q070203, ENSP000000847954I2D: score=2 STRING: ENSP00000084795
    RPL22P352682, ENSP000003460884MINT-7947479 STRING: ENSP00000346088
    RPS5P467823, ENSP000001965514I2D: score=2 STRING: ENSP00000196551
    EIF4EP067303, ENSP000002808924I2D: score=5 STRING: ENSP00000280892
    EIF3EP602283, ENSP000002208494I2D: score=1 STRING: ENSP00000220849
    EIF3KQ9UBQ53, ENSP000002483424I2D: score=1 STRING: ENSP00000248342
    UBCP0CG483, ENSP000003448184I2D: score=2 STRING: ENSP00000344818
    EIF3MQ7L2H73, ENSP000003199104I2D: score=1 STRING: ENSP00000319910
    IL2RBP147843, ENSP000002162234I2D: score=2 STRING: ENSP00000216223
    EIF4BP235883, ENSP000002620564I2D: score=2 STRING: ENSP00000262056
    EIF6P565373, ENSP000003635594I2D: score=5 STRING: ENSP00000363559
    RPS6P627533, ENSP000003697574I2D: score=5 STRING: ENSP00000369757
    GTF2BQ004033, ENSP000003595314I2D: score=4 STRING: ENSP00000359531
    ARPC3O151453, ENSP000002288254I2D: score=4 STRING: ENSP00000228825
    TADA2AO754783, ENSP000002253964I2D: score=1 STRING: ENSP00000225396
    RPS11P622803, ENSP000002706254I2D: score=1 STRING: ENSP00000270625
    TRUB1Q8WWH52, ENSP000002987464MINT-7947479 STRING: ENSP00000298746
    CDC5LQ994592, ENSP000003605324MINT-7947479 STRING: ENSP00000360532
    NSA2O954783, ENSP000002968024I2D: score=1 STRING: ENSP00000296802
    IPO5O004102, ENSP000002615744MINT-7947479 STRING: ENSP00000261574
    ARFRP1Q137953, ENSP000003268844I2D: score=3 STRING: ENSP00000326884
    BOP1Q141373, ENSP000003041514I2D: score=4 STRING: ENSP00000304151
    PABPC1P119403, ENSP000003130074I2D: score=1 STRING: ENSP00000313007
    RPS19P390193, ENSP000002219754I2D: score=1 STRING: ENSP00000221975
    PLECQ151492, ENSP000003238564MINT-7947479 STRING: ENSP00000323856
    ABCF1Q8NE712, ENSP000003136034MINT-7947479 STRING: ENSP00000313603
    ENSG00000206490Q8NE712, ENSP000003730824MINT-7947479 STRING: ENSP00000373082
    ENSG00000225989Q8NE712, ENSP000004113274MINT-7947479 STRING: ENSP00000411327
    ENSG00000231129Q8NE712, ENSP000004143734MINT-7947479 STRING: ENSP00000414373
    ENSG00000232169Q8NE712, ENSP000003890654MINT-7947479 STRING: ENSP00000389065
    ENSG00000236149Q8NE712, ENSP000004133194MINT-7947479 STRING: ENSP00000413319
    ENSG00000236342Q8NE712, ENSP000004125534MINT-7947479 STRING: ENSP00000412553
    ABCF3Q9NUQ82, ENSP000004114714MINT-7947479 STRING: ENSP00000411471
    COPS5Q929052, ENSP000003505124MINT-7947479 STRING: ENSP00000350512
    EEF1A1P681042, ENSP000003300544MINT-7947479 STRING: ENSP00000330054
    EIF5BO608412, ENSP000002893714MINT-7947479 STRING: ENSP00000289371
    RPL31P628992, ENSP000003867174MINT-7947479 STRING: ENSP00000386717
    RPLP0P053882, ENSP000003390274MINT-7947479 STRING: ENSP00000339027
    TNPO1Q929732, ENSP000003367124MINT-7947479 STRING: ENSP00000336712
    USP10Q146942, ENSP000002194734MINT-7947479 STRING: ENSP00000219473
    XRN2Q9H0D62, ENSP000003663964MINT-7947479 STRING: ENSP00000366396
    OSBPP220593I2D: score=3 
    XPAP230253I2D: score=3 
    ATG9AQ7Z3C63I2D: score=2 
    EML1O004233I2D: score=2 
    HSPH1Q925983I2D: score=2 
    NUDT6P533703I2D: score=2 
    RALAP112333I2D: score=2 
    RPSAP088653I2D: score=2 
    SUPT5HO002673I2D: score=2 
    ACAT1P247523I2D: score=1 
    ACTR3BQ9P1U13I2D: score=1 
    APCP250543I2D: score=1 
    ARPC2O151443I2D: score=1 
    ARPC4P599983I2D: score=1 
    ATG5Q9H1Y03I2D: score=1 
    BMS1Q146923I2D: score=1 
    BRIX1Q8TDN63I2D: score=1 
    CD4P017303I2D: score=1 
    CHD2O146473I2D: score=1 
    CHN2P527573I2D: score=1 
    CNBPP626333I2D: score=1 
    CSO753903I2D: score=1 
    CTSAP106193I2D: score=1 
    DDA1Q9BW613I2D: score=1 
    DDX18Q9NVP13I2D: score=1 
    DDX27Q96GQ73I2D: score=1 
    DDX54Q8TDD13I2D: score=1 
    GABARAPL1Q9H0R83I2D: score=1 
    GBASO753233I2D: score=1 
    GNL2Q138233I2D: score=1 
    GRB7Q144513I2D: score=1 
    GTPBP4Q9BZE43I2D: score=1 
    HSPA9P386463I2D: score=1 
    IKBKEQ141643I2D: score=1 
    KIAA0020Q153973I2D: score=1 
    LIASO437663I2D: score=1 
    LSG1Q9H0893I2D: score=1 
    ME1P481633I2D: score=1 
    MECRQ9BV793I2D: score=1 
    MRTO4Q9UKD23I2D: score=1 
    NOC2LQ9Y3T93I2D: score=1 
    NOC3LQ8WTT23I2D: score=1 
    NOL6Q9H6R43I2D: score=1 
    NRBF2Q96F243I2D: score=1 
    NVLO153813I2D: score=1 
    OTUD6BQ8N6M03I2D: score=1 
    OXSMQ9NWU13I2D: score=1 
    PES1O005413I2D: score=1 
    PIK3C2AO004433I2D: score=1 
    POLR1BQ9H9Y63I2D: score=1 
    PPM1GO153553I2D: score=1 
    PRKAG1P546193I2D: score=1 
    PRKAG2Q9UGJ03I2D: score=1 
    PRKAR2AP138613I2D: score=1 
    PSMD14O004873I2D: score=1 
    PYCRLQ53H963I2D: score=1 
    RPA1P276943I2D: score=1 
    RPF1Q9H9Y23I2D: score=1 
    RPF2Q9H7B23I2D: score=1 
    SDAD1Q9NVU73I2D: score=1 
    SLC2A4P146723I2D: score=1 
    SLC30A10Q6XR723I2D: score=1 
    SMEK2Q5MIZ73I2D: score=1 
    USP22Q9UPT93I2D: score=1 
    ZC3H15Q8WU903I2D: score=1 
    ACTL6AO960192MINT-7947479
    ACTR1AP611632MINT-7947479
    ADNPQ9H2P02MINT-7947479
    AHNAKQ096662MINT-7947479
    AKAP8O438232MINT-7947479
    ANAPC1Q9H1A42MINT-7947479
    ANAPC2Q9UJX62MINT-7947479
    ANAPC7Q9UJX32MINT-7947479
    ANLNQ9NQW62MINT-7947479
    ANXA11P509952MINT-7947479
    AP1B1Q105672MINT-7947479
    ARCN1P484442MINT-7947479
    ARGLU1Q9NWB62MINT-7947479
    ARHGEF1Q928882MINT-7947479
    ARHGEF2Q929742MINT-7947479
    ARID1AO144972MINT-7947479
    AURKBQ96GD42MINT-7947479
    BAZ1AQ9NRL22MINT-7947479
    BCAS2O759342MINT-7947479
    BCLAF1Q9NYF82MINT-7947479
    BIDP559572MINT-7947479
    BRD2P254402MINT-7947479
    BRD4O608852MINT-7947479
    BRD7Q9NPI12MINT-7947479
    BRD8Q9H0E92MINT-7947479
    BTAF1O149812MINT-7947479
    BUB1O436832MINT-7947479
    BUB1BO605662MINT-7947479
    BUB3O436842MINT-7947479
    BZW1Q7L1Q62MINT-7947479
    C7orf13Q8NI282MINT-7947479
    CAPGP401212MINT-7947479
    CAPZA1P529072MINT-7947479
    CARD10Q9BWT72MINT-7947479
    CASC5Q8NG312MINT-7947479
    CCNB1P146352MINT-7947479
    CCT2P783712MINT-7947479
    CCT4P509912MINT-7947479
    CCT5P486432MINT-7947479
    CCT6AP402272MINT-7947479
    CCT7Q998322MINT-7947479
    CCT8P509902MINT-7947479
    CDC16Q130422MINT-7947479
    CDC20Q128342MINT-7947479
    CDC23Q9UJX22MINT-7947479
    CDC27P302602MINT-7947479
    CDC73Q6P1J92MINT-7947479
    CDK9P507502MINT-7947479
    CDKN2AIPQ9NXV62MINT-7947479
    CHD1LQ86WJ12MINT-7947479
    CHD8Q9HCK82MINT-7947479
    CHEK1O147572MINT-7947479
    CKAP5Q140082MINT-7947479
    CLASP1Q7Z4602MINT-7947479
    CLINT1Q146772MINT-7947479
    CNOT10Q9H9A52MINT-7947479
    CNOT3O751752MINT-7947479
    COPAP536212MINT-7947479
    COPB1P536182MINT-7947479
    COPB2P356062MINT-7947479
    COPG1Q9Y6782MINT-7947479
    COPG2Q9UBF22MINT-7947479
    CPSF2Q9P2I02MINT-7947479
    CPSF3Q9UKF62MINT-7947479
    CPSF7Q8N6842MINT-7947479
    CSE1LP550602MINT-7947479
    CSTF3Q129962MINT-7947479
    CTNND1O607162MINT-7947479
    CUL1Q136162MINT-7947479
    CWC15Q9P0132MINT-7947479
    DCTN2Q135612MINT-7947479
    DDB1Q165312MINT-7947479
    DDX17Q928412MINT-7947479
    DDX19AQ9NUU72MINT-7947479
    DDX19BQ9UMR22MINT-7947479
    DDX39AO001482MINT-7947479
    DDX39BQ138382MINT-7947479
    DDX41Q9UJV92MINT-7947479
    DDX42Q86XP32MINT-7947479
    DDX47Q9H0S42MINT-7947479
    DDX5P178442MINT-7947479
    DEPDC7Q96QD52MINT-7947479
    DFNA5O604432MINT-7947479
    DIAPH1O606102MINT-7947479
    DIDO1Q9BTC02MINT-7947479
    DMAP1Q9NPF52MINT-7947479
    DNM1LO004292MINT-7947479
    DNM2P505702MINT-7947479
    DOCK5Q9H7D02MINT-7947479
    DOCK8Q8NF502MINT-7947479
    DRG1Q9Y2952MINT-7947479
    DSPP159242MINT-7947479
    DTYMKP239192MINT-7947479
    DYNC1H1Q142042MINT-7947479
    DYNC1LI1Q9Y6G92MINT-7947479
    DYNC1LI2O432372MINT-7947479
    ECT2Q9H8V32MINT-7947479
    EDC4Q6P2E92MINT-7947479
    EFTUD2Q150292MINT-7947479
    EHD1Q9H4M92MINT-7947479
    EHD4Q9H2232MINT-7947479
    EHMT1Q9H9B12MINT-7947479
    EIF2B4Q9UI102MINT-7947479
    EIF2DP412142MINT-7947479
    EIF4A2Q142402MINT-7947479
    EIF4A3P389192MINT-7947479
    EIF4G2P783442MINT-7947479
    ELAVL1Q157172MINT-7947479
    ELF2Q157232MINT-7947479
    ENAHQ8N8S72MINT-7947479
    ENSG00000183311P074372MINT-7947479
    ENSG00000206289P287022MINT-7947479
    ENSG00000215077P254402MINT-7947479
    ENSG00000215425Q138382MINT-7947479
    ENSG00000224156P074372MINT-7947479
    ENSG00000225073Q138382MINT-7947479
    ENSG00000225859Q138382MINT-7947479
    ENSG00000227322P287022MINT-7947479
    ENSG00000227739P074372MINT-7947479
    ENSG00000228333P287022MINT-7947479
    ENSG00000229496Q138382MINT-7947479
    ENSG00000229684P074372MINT-7947479
    ENSG00000230624Q138382MINT-7947479
    ENSG00000231321P287022MINT-7947479
    ENSG00000232421P074372MINT-7947479
    ENSG00000232575P074372MINT-7947479
    ENSG00000234507P254402MINT-7947479
    ENSG00000234704P254402MINT-7947479
    ENSG00000235067P074372MINT-7947479
    ENSG00000235307P254402MINT-7947479
    ENSG00000235439Q138382MINT-7947479
    ENSG00000235712P287022MINT-7947479
    EPB41L3Q9Y2J22MINT-7947479
    EPPK1P581072MINT-7947479
    EPS8L2Q9H6S32MINT-7947479
    ERAL1O756162MINT-7947479
    ERCC1P079922MINT-7947479
    ERCC6LQ2NKX82MINT-7947479
    ETV6P412122MINT-7947479
    EWSR1Q018442MINT-7947479
    EXOC2Q96KP12MINT-7947479
    EXOC4Q96A652MINT-7947479
    EXOC5O004712MINT-7947479
    EXOC7Q9UPT52MINT-7947479
    EXOSC10Q017802MINT-7947479
    FAF1Q9UNN52MINT-7947479
    FAM129BQ96TA12MINT-7947479
    FANCD2Q9BXW92MINT-7947479
    FANCIQ9NVI12MINT-7947479
    FASNP493272MINT-7947479
    FEN1P397482MINT-7947479
    FERMT1Q9BQL62MINT-7947479
    FHOD1Q9Y6132MINT-7947479
    FUSP356372MINT-7947479
    GAPDHP044062MINT-7947479
    GATAD2AQ86YP42MINT-7947479
    GCN1L1Q926162MINT-7947479
    GEMIN4P576782MINT-7947479
    GEMIN6Q8WXD52MINT-7947479
    GMPSP499152MINT-7947479
    GNASP630922MINT-7947479
    GNB3P165202MINT-7947479
    GOLGB1Q147892MINT-7947479
    GPS2Q132272MINT-7947479
    GTF2IP783472MINT-7947479
    GTF3C2Q8WUA42MINT-7947479
    GTF3C5Q9Y5Q82MINT-7947479
    GTPBP1O001782MINT-7947479
    GULP1Q9UBP92MINT-7947479
    HAUS7Q998712MINT-7947479
    HBS1LQ9Y4502MINT-7947479
    HDAC1Q135472MINT-7947479
    HDAC2Q927692MINT-7947479
    HDLBPQ003412MINT-7947479
    HELLSQ9NRZ92MINT-7947479
    HIC2Q96JB32MINT-7947479
    HIP1RO751462MINT-7947479
    HIRAP541982MINT-7947479
    HLTFQ145272MINT-7947479
    HNRNPA2B1P226262MINT-7947479
    HNRNPCP079102MINT-7947479
    HNRNPFP525972MINT-7947479
    HNRNPH1P319432MINT-7947479
    HNRNPKP619782MINT-7947479
    HNRNPMP522722MINT-7947479
    HNRNPUQ008392MINT-7947479
    HSP90AB1P082382MINT-7947479
    HSP90B1P146252MINT-7947479
    HSPA12AO433012MINT-7947479
    HSPA6P170662MINT-7947479
    HSPB1P047922MINT-7947479
    HSPD1P108092MINT-7947479
    HUWE1Q7Z6Z72MINT-7947479
    IKBKAPO951632MINT-7947479
    ILF2Q129052MINT-7947479
    INTS1Q8N2012MINT-7947479
    INTS3Q68E012MINT-7947479
    INTS6Q9UL032MINT-7947479
    INTS8Q75QN22MINT-7947479
    IPO7O953732MINT-7947479
    IPO9Q96P702MINT-7947479
    IQGAP1P469402MINT-7947479
    ITPK1Q135722MINT-7947479
    KANSL1Q7Z3B32MINT-7947479
    KDM1AO603412MINT-7947479
    KHDRBS1Q076662MINT-7947479
    KIF11P527322MINT-7947479
    KIF21AQ7Z4S62MINT-7947479
    KIF2CQ996612MINT-7947479
    KIF4AO952392MINT-7947479
    KPNA2P522922MINT-7947479
    LAS1LQ9Y4W22MINT-7947479
    LENG9Q96B702MINT-7947479
    LIMS1P480592MINT-7947479
    LMNAP025452MINT-7947479
    LMO7Q8WWI12MINT-7947479
    LRRC1Q9BTT62MINT-7947479
    LRRC40Q9H9A62MINT-7947479
    LRWD1Q9UFC02MINT-7947479
    MAD1L1Q9Y6D92MINT-7947479
    MAGEE2Q8TD902MINT-7947479
    MAP2K4P459852MINT-7947479
    MAP2K7O147332MINT-7947479
    MAP7Q142442MINT-7947479
    MARK2Q7KZI72MINT-7947479
    MATR3P432432MINT-7947479
    MDN1Q9NU222MINT-7947479
    MED12Q930742MINT-7947479
    MED12LQ86YW92MINT-7947479
    MED16Q9Y2X02MINT-7947479
    MED4Q9NPJ62MINT-7947479
    MELKQ146802MINT-7947479
    MPP2Q141682MINT-7947479
    MRE11AP499592MINT-7947479
    MSH2P432462MINT-7947479
    MSH6P527012MINT-7947479
    MTA2O947762MINT-7947479
    MTA3Q9BTC82MINT-7947479
    MTCL1Q9Y4B52MINT-7947479
    MVPQ147642MINT-7947479
    MYBBP1AQ9BQG02MINT-7947479
    MYH9P355792MINT-7947479
    MYO15BQ96JP22MINT-7947479
    NACC1Q96RE72MINT-7947479
    NAT10Q9H0A02MINT-7947479
    NBNO609342MINT-7947479
    NCAPD2Q150212MINT-7947479
    NCAPHQ150032MINT-7947479
    NCOR1O753762MINT-7947479
    NDC80O147772MINT-7947479
    NELFBQ8WX922MINT-7947479
    NF1P213592MINT-7947479
    NIPBLQ6KC792MINT-7947479
    NONOQ152332MINT-7947479
    NPM1P067482MINT-7947479
    NRG1Q022972MINT-7947479
    NSFP464592MINT-7947479
    NSUN5Q96P112MINT-7947479
    NUDCQ9Y2662MINT-7947479
    NUDT21O438092MINT-7947479
    NUF2Q9BZD42MINT-7947479
    NUP107P577402MINT-7947479
    NUP155O756942MINT-7947479
    NUP93Q8N1F72MINT-7947479
    ORC2Q134162MINT-7947479
    ORC3Q9UBD52MINT-7947479
    OXSR1O957472MINT-7947479
    PAK4O960132MINT-7947479
    PARP1P098742MINT-7947479
    PARVAQ9NVD72MINT-7947479
    PARVBQ9HBI12MINT-7947479
    PCBP1Q153652MINT-7947479
    PCBP2Q153662MINT-7947479
    PCNTO956132MINT-7947479
    PDLIM7Q9NR122MINT-7947479
    PELOQ9BRX22MINT-7947479
    PFKMP082372MINT-7947479
    PFKPQ018132MINT-7947479
    PHGDHO431752MINT-7947479
    PICALMQ134922MINT-7947479
    PKN2Q165132MINT-7947479
    PNNQ9H3072MINT-7947479
    POLD1P283402MINT-7947479
    POLR1CO151602MINT-7947479
    POLR3DP054232MINT-7947479
    POLR3EQ9NVU02MINT-7947479
    PPFIA1Q131362MINT-7947479
    PPM1DO152972MINT-7947479
    PPP1CAP621362MINT-7947479
    PPP2R1AP301532MINT-7947479
    PRCCQ927332MINT-7947479
    PRKDCP785272MINT-7947479
    PRPF19Q9UMS42MINT-7947479
    PRPF3O433952MINT-7947479
    PRPF4BQ135232MINT-7947479
    PRPF6O949062MINT-7947479
    PRPF8Q6P2Q92MINT-7947479
    PSMC1P621912MINT-7947479
    PSMC2P359982MINT-7947479
    PSMC3P179802MINT-7947479
    PSMC4P436862MINT-7947479
    PSMC5P621952MINT-7947479
    PSMC6P623332MINT-7947479
    PSMD1Q994602MINT-7947479
    PSMD11O002312MINT-7947479
    PSMD12O002322MINT-7947479
    PSMD13Q9UNM62MINT-7947479
    PSMD3O432422MINT-7947479
    PSTPIP2Q9H9392MINT-7947479
    PTBP1P265992MINT-7947479
    PTBP2Q9UKA92MINT-7947479
    PTBP3O957582MINT-7947479
    PUM1Q146712MINT-7947479
    RACGAP1Q9H0H52MINT-7947479
    RAD18Q9NS912MINT-7947479
    RAD50Q928782MINT-7947479
    RALYQ9UKM92MINT-7947479
    RANBP2P497922MINT-7947479
    RANGAP1P460602MINT-7947479
    RAVER1Q8IY672MINT-7947479
    RBBP5Q152912MINT-7947479
    RBBP7Q165762MINT-7947479
    RBM17Q96I252MINT-7947479
    RBM39Q144982MINT-7947479
    RBM4Q9BWF32MINT-7947479
    RBM45Q8IUH32MINT-7947479
    RBM7Q9Y5802MINT-7947479
    RBMXP381592MINT-7947479
    RCOR1Q9UKL02MINT-7947479
    RFC2P352502MINT-7947479
    RFC3P409382MINT-7947479
    RFC4P352492MINT-7947479
    RFC5P409372MINT-7947479
    RFX1P226702MINT-7947479
    RFX5P483822MINT-7947479
    RIF1Q5UIP02MINT-7947479
    RNF130Q86XS82MINT-7947479
    RNF17Q9BXT82MINT-7947479
    ROCK2O751162MINT-7947479
    RPL13P263732MINT-7947479
    RPL24P837312MINT-7947479
    RPS6KA4O756762MINT-7947479
    RPS6KB2Q9UBS02MINT-7947479
    RTCBQ9Y3I02MINT-7947479
    RUVBL1Q9Y2652MINT-7947479
    RXRBP287022MINT-7947479
    SART1O432902MINT-7947479
    SCAF8Q9UPN62MINT-7947479
    SCRIBQ141602MINT-7947479
    SCYL2Q6P3W72MINT-7947479
    SEC23AQ154362MINT-7947479
    SEC24CP539922MINT-7947479
    SEH1LQ96EE32MINT-7947479
    SENP3Q9H4L42MINT-7947479
    SEPT9Q9UHD82MINT-7947479
    SETXQ7Z3332MINT-7947479
    SF3A1Q154592MINT-7947479
    SF3A2Q154282MINT-7947479
    SF3A3Q128742MINT-7947479
    SF3B1O755332MINT-7947479
    SF3B2Q134352MINT-7947479
    SF3B3Q153932MINT-7947479
    SF3B6Q9Y3B42MINT-7947479
    SFPQP232462MINT-7947479
    SHC1P293532MINT-7947479
    SHROOM3Q8TF722MINT-7947479
    SIN3AQ96ST32MINT-7947479
    SKIV2L2P422852MINT-7947479
    SMARCA5O602642MINT-7947479
    SMARCAD1Q9H4L72MINT-7947479
    SMARCB1Q128242MINT-7947479
    SMARCC1Q929222MINT-7947479
    SMARCC2Q8TAQ22MINT-7947479
    SMARCD1Q96GM52MINT-7947479
    SMARCE1Q969G32MINT-7947479
    SMC1AQ146832MINT-7947479
    SMC2O953472MINT-7947479
    SMC3Q9UQE72MINT-7947479
    SMC4Q9NTJ32MINT-7947479
    SMCHD1A6NHR92MINT-7947479
    SMN1Q166372MINT-7947479
    SMN2Q166372MINT-7947479
    SNAPC4Q5SXM22MINT-7947479
    SNRNP200O756432MINT-7947479
    SNRNP40Q96DI72MINT-7947479
    SNRNP70P086212MINT-7947479
    SNRPAP090122MINT-7947479
    SNRPA1P096612MINT-7947479
    SNRPD1P623142MINT-7947479
    SNRPD3P623182MINT-7947479
    SNRPEP623042MINT-7947479
    SNW1Q135732MINT-7947479
    SNX12Q9UMY42MINT-7947479
    SNX2O607492MINT-7947479
    SPATA5Q8NB902MINT-7947479
    SPENQ96T582MINT-7947479
    SPTAN1Q138132MINT-7947479
    SPTBN1Q010822MINT-7947479
    SREK1Q8WXA92MINT-7947479
    SRP54P610112MINT-7947479
    SRP68Q9UHB92MINT-7947479
    SRP72O760942MINT-7947479
    SRRM1Q8IYB32MINT-7947479
    SRSF1Q079552MINT-7947479
    SRSF4Q081702MINT-7947479
    SRSF7Q166292MINT-7947479
    SSUH2Q9Y2M22MINT-7947479
    STAB1Q9NY152MINT-7947479
    STAG2Q8N3U42MINT-7947479
    STAT3P407632MINT-7947479
    STK24Q9Y6E02MINT-7947479
    SUGT1Q9Y2Z02MINT-7947479
    SUMO1P631652MINT-7947479
    SYMPKQ927972MINT-7947479
    TAF15Q928042MINT-7947479
    TAF5LO755292MINT-7947479
    TANC2Q9HCD62MINT-7947479
    TARDBPQ131482MINT-7947479
    TBL1XR1Q9BZK72MINT-7947479
    THAP1Q9NVV92MINT-7947479
    THRAP3Q9Y2W12MINT-7947479
    TIAL1Q010852MINT-7947479
    TLN1Q9Y4902MINT-7947479
    TLN2Q9Y4G62MINT-7947479
    TMOD3Q9NYL92MINT-7947479
    TMPOP421662MINT-7947479
    TNFAIP2Q031692MINT-7947479
    TNKS1BP1Q9C0C22MINT-7947479
    TPRP122702MINT-7947479
    TPX2Q9ULW02MINT-7947479
    TRAP1Q129312MINT-7947479
    TRIM21P194742MINT-7947479
    TRIM28Q132632MINT-7947479
    TRIP13Q156452MINT-7947479
    TRMT1LQ7Z2T52MINT-7947479
    TRRAPQ9Y4A52MINT-7947479
    TSG101Q998162MINT-7947479
    TUBA1CQ9BQE32MINT-7947479
    TUBA4AP683662MINT-7947479
    TUBBP074372MINT-7947479
    TUBB4BP683712MINT-7947479
    TUBG1P232582MINT-7947479
    TUBGCP2Q9BSJ22MINT-7947479
    TUBGCP3Q96CW52MINT-7947479
    TUBGCP4Q9UGJ12MINT-7947479
    TWF1Q127922MINT-7947479
    U2AF1Q010812MINT-7947479
    U2AF2P263682MINT-7947479
    U2SURPO150422MINT-7947479
    UBE2MP610812MINT-7947479
    UBE2NP610882MINT-7947479
    UBE2SQ167632MINT-7947479
    UBL4AP114412MINT-7947479
    UBN1Q9NPG32MINT-7947479
    UCHL5Q9Y5K52MINT-7947479
    UMPSP111722MINT-7947479
    UNC45AQ9H3U12MINT-7947479
    USO1O607632MINT-7947479
    USP24Q9UPU52MINT-7947479
    USP39Q53GS92MINT-7947479
    VIMP086702MINT-7947479
    VPS33AQ96AX12MINT-7947479
    VPS33BQ9H2672MINT-7947479
    VPS36Q86VN12MINT-7947479
    VPS51Q9UID32MINT-7947479
    WDR18Q9BV382MINT-7947479
    WDR33Q9C0J82MINT-7947479
    WRNIP1Q96S552MINT-7947479
    XPO5Q9HAV42MINT-7947479
    YEATS4O956192MINT-7947479
    YLPM1P497502MINT-7947479
    YWHAEP622582MINT-7947479
    ZBTB7CA1YPR02MINT-7947479
    ZC3HC1Q86WB02MINT-7947479
    ZNF638Q149662MINT-7947479
    LOC255308ENSP000003230634MINT-7947479 STRING: ENSP00000323063
    EIF3CLENSP000003702584STRING: ENSP00000370258
    EIF4HENSP000002657534STRING: ENSP00000265753
    RPL11ENSP000003636764STRING: ENSP00000363676
    RPL12ENSP000003547394STRING: ENSP00000354739
    RPL18AENSP000002222474STRING: ENSP00000222247
    RPL23ENSP000003778654STRING: ENSP00000377865
    RPL27ENSP000002537884STRING: ENSP00000253788
    RPL27AENSP000003460154STRING: ENSP00000346015
    RPL28ENSP000004014504STRING: ENSP00000401450
    RPL29ENSP000002941894STRING: ENSP00000294189
    RPL30ENSP000002870384STRING: ENSP00000287038
    RPL34ENSP000003781604STRING: ENSP00000378160
    RPL35ENSP000002594694STRING: ENSP00000259469
    RPL35AENSP000003933934STRING: ENSP00000393393
    RPL36ENSP000002525434STRING: ENSP00000252543
    RPL37ENSP000002742424STRING: ENSP00000274242
    RPL37AENSP000004180824STRING: ENSP00000418082
    RPL38ENSP000003098304STRING: ENSP00000309830
    RPL5ENSP000003593454STRING: ENSP00000359345
    RPL6ENSP000002027734STRING: ENSP00000202773
    RPL7AENSP000003610764STRING: ENSP00000361076
    RPL9ENSP000003460224STRING: ENSP00000346022
    RPLP1ENSP000003460374STRING: ENSP00000346037
    RPLP2ENSP000003224194STRING: ENSP00000322419
    RPS14ENSP000003110284STRING: ENSP00000311028
    RPS16ENSP000002514534STRING: ENSP00000251453
    RPS17ENSP000003460454STRING: ENSP00000346045
    RPS20ENSP000000095894STRING: ENSP00000009589
    RPS23ENSP000002966744STRING: ENSP00000296674
    RPS24ENSP000004143214STRING: ENSP00000414321
    RPS29ENSP000003793394STRING: ENSP00000379339
    RPS3ENSP000002785724STRING: ENSP00000278572
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001731formation of translation preinitiation complex IEA--
    GO:0006412translation TAS--
    GO:0006413translational initiation TAS--
    GO:0006446regulation of translational initiation IDA8995410
    GO:0010467gene expression TAS--

    Find genes that share ontologies with EIF3B           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
    About This Section

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    Browse Small Molecules at EMD Millipore
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      Browse compounds at ApexBio 

    Browse Tocris compounds for EIF3B



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
    About This Section

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    REFSEQ mRNAs for EIF3B gene (2 alternative transcripts): 
    NM_001037283.1  NM_003751.3  

    Unigene Cluster for EIF3B:

    Eukaryotic translation initiation factor 3, subunit B
    Hs.371001  [show with all ESTs]
    Unigene Representative Sequence: AB209381
    12 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000431643 ENST00000360876(uc003slx.3 uc003sly.3 uc003slz.1)
    ENST00000413917 ENST00000397011(uc003sma.3) ENST00000463229 ENST00000463026
    ENST00000468250 ENST00000466199 ENST00000475415 ENST00000468611(uc003smb.3)
    ENST00000465670 ENST00000494658
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat EIF3B using miScript Target Protectors
    6 qRT-PCR Assays for microRNAs that regulate EIF3B:
    hsa-miR-3140-3p hsa-miR-124 hsa-miR-198 hsa-miR-525-5p hsa-miR-506 hsa-miR-520a-5p
    SwitchGear 3'UTR luciferase reporter plasmidEIF3B 3' UTR sequence
    Inhib. RNA
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    OriGene RNAi products in human, mouse, rat for EIF3B
    Predesigned siRNA for gene silencing in human, mouse, rat EIF3B
    Clone
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    OriGene clones in human, mouse for EIF3B (see all 12)
    OriGene ORF clones in mouse, rat for EIF3B
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): EIF3B (NM_003751)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for EIF3B
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat EIF3B
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for EIF3B
    OriGene qSTAR qPCR primer pairs in human, mouse for EIF3B
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat EIF3B
      QuantiTect SYBR Green Assays in human, mouse, rat EIF3B
      QuantiFast Probe-based Assays in human, mouse, rat EIF3B

    Additional mRNA sequence: 

    AB209381.1 AK127885.1 AK300967.1 AK302058.1 BC001173.1 BC009986.1 BC110865.1 U62583.1 
    U78525.1 

    Selected DOTS entries (see all 35):

    DT.100834695  DT.97798019  DT.100759692  DT.95173385  DT.100834690  DT.454061  DT.100730058  DT.429116 
    DT.92462641  DT.97786597  DT.203336  DT.70104982  DT.102836765  DT.100039603  DT.95305235  DT.95148198 
    DT.97864515  DT.121124337  DT.95313948  DT.100834693  DT.121124353  DT.100033517  DT.100834684  DT.100834692 

    Selected AceView cDNA sequences (see all 758):

    BM919002 BC001173 AI204368 AI699769 AW613698 BU857372 CF131575 BQ184896 
    AU124102 BM790290 AW189503 BU742454 CD360052 CB158647 BQ430432 CA414423 
    BU179964 BU729506 BF813415 BM459410 BU520863 BG392270 BQ221471 AI677741 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for EIF3B (see all 18)    About this scheme

    ExUns: 1 ^ 2 ^ 3a · 3b · 3c ^ 4a · 4b ^ 5a · 5b ^ 6a · 6b ^ 7a · 7b ^ 8a · 8b ^ 9a · 9b · 9c ^ 10 ^ 11a · 11b ^ 12a · 12b ^ 13 ^ 14 ^ 15a ·
    SP1:                                                                                            -                             -           -     -               
    SP2:                                                                                            -                             -           -     -               
    SP3:                                                                                            -                             -           -     -               
    SP4:                                                                                            -                             -           -     -               
    SP5:        -     -     -     -                                                                                                                                 

    ExUns: 15b · 15c ^ 16 ^ 17a · 17b ^ 18 ^ 19a · 19b · 19c ^ 20a · 20b ^ 21 ^ 22a · 22b ^ 23a · 23b ^ 24a · 24b · 24c
    SP1:        -           -                 -                                         -     -           -               
    SP2:        -           -                 -                                         -                                 
    SP3:        -           -                 -                                         -     -                           
    SP4:        -           -                 -                                         -     -                           
    SP5:                                                                                                                  


    ECgene alternative splicing isoforms for EIF3B

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

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    EIF3B expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GAAATAAAAG
    EIF3B Expression
    About this image


    EIF3B expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 13) fully expand
     
     Brain (Nervous System)    fully expand to see all 4 entries
             Cerebral Cortex
     
     Ovary (Reproductive System)    fully expand to see all 2 entries
             Ovarian Mesenchymal Stroma Cells Ovary Interstitium
             Oviduct
     
     Testis (Reproductive System)
             Leydig Cells Testis Interstitium
     
     Bone (Muscoskeletal System)
             Bone Marrow
     
     Trophoblast (Extraembryonic Tissues)
             Trophoblast Cells Trophoblast
    EIF3B Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    EIF3B Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.371001
        Custom PCR Arrays for EIF3B
    Primer
    Products:
    OriGene qPCR primer pairs and template standards for EIF3B
    OriGene qSTAR qPCR primer pairs in human, mouse for EIF3B
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat EIF3B
    QuantiTect SYBR Green Assays in human, mouse, rat EIF3B
    QuantiFast Probe-based Assays in human, mouse, rat EIF3B
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for EIF3B

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of eukaryotes.

    Orthologs for EIF3B gene from Selected species (see all 25)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Eif3b1 , 5 eukaryotic translation initiation factor 3, subunit more1, 5 85.01(n)1
    91.53(a)1
      5 (78.97 cM)5
    279791  NM_133916.21  NP_598677.11 
     1404193055 
    chicken
    (Gallus gallus)
    Aves EIF3B1 eukaryotic translation initiation factor 3, subunit more 78.95(n)
    88.5(a)
      769783  XM_003642142.2  XP_003642190.2 
    lizard
    (Anolis carolinensis)
    Reptilia --
    --
    Uncharacterized protein
    73(a)
    59(a)
    many → 1
    many → 1
    GL343340.1(41712-52758)
    GL343307.1(1301747-1303336)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.260732 Xenopus laevis transcribed sequence with moderate similarity more 77.37(n)    48055327 
    zebrafish
    (Danio rerio)
    Actinopterygii wufc17c012 wufc17c01 82.82(n)   324028  CA787533.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta eIF3-S91 eIF3-S9 58.46(n)
    53.67(a)
      36981  NM_166239.3  NP_725691.1 
    worm
    (Caenorhabditis elegans)
    Secernentea eif-3.B6
    Protein EIF-3.B, isoform a
    34(a)
    1 ↔ 1
    II(14795404-14798234) WBGene00001225
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes PRT1(YOR361C)4
    PRT11
    eIF3b subunit of the core complex of translation initiation more4
    PRT11
    48.34(n)1
    35.57(a)1
      15(1017652-1015361)4
    8545431, 4  NP_015006.31  NP_015006.14 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons EIF3B-21 EIF3B-2 53.14(n)
    43.26(a)
      832647  NM_122479.3  NP_568477.1 
    rice
    (Oryza sativa)
    Liliopsida Os.48992 Oryza sativa (japonica cultivar-group) cDNA clone0 more 70.36(n)    AK110143.1 


    ENSEMBL Gene Tree for EIF3B (if available)
    TreeFam Gene Tree for EIF3B (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

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    Paralogs for EIF3B gene
    1 SIMAP similar gene for EIF3B using alignment to 7 protein entries:     EIF3B_HUMAN (see all proteins):
    EIF3S9

    Find genes that share paralogs with EIF3B           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

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    Selected SNPs for EIF3B (see all 980)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 7 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs77959371,2
    C--2392502(+) cttatC/Tgtaca 2 -- us2k10--------
    rs1866445271,2
    --2392544(+) ACCTGC/TCCAAA 2 -- us2k10--------
    rs1911089171,2
    C--2392571(+) CATGAC/TGAGGA 2 -- us2k10--------
    rs1405732621,2
    --2392678(+) AGTCCC/TGGCAC 2 -- us2k10--------
    rs749343721,2
    F--2392748(+) ACACAG/ATGAGA 2 -- us2k11Minor allele frequency- A:0.03NA 120
    rs1457357701,2
    --2392785(+) TGGGCA/GCGGTG 2 -- us2k10--------
    rs624441621,2
    C,F--2392860(+) GCATAT/CTAAAA 2 -- us2k12Minor allele frequency- C:0.08NA 122
    rs1825669971,2
    --2392876(+) AGGCCC/GTGCGC 2 -- us2k10--------
    rs1418556821,2
    --2392881(+) CTGCGC/GGGTGG 2 -- us2k10--------
    rs77929341,2
    C,F--2393016(+) accctG/Atctct 2 -- us2k112Minor allele frequency- A:0.24NA WA CSA EA 374

    HapMap Linkage Disequilibrium report for EIF3B (2393721 - 2420380 bp)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for EIF3B (see all 14):    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2733848CNV Deletion23290073
    esv2663485CNV Deletion23128226
    dgv1118e201CNV Deletion23290073
    esv2424013CNV Deletion19546169
    esv2733846CNV Deletion23290073
    esv2733849CNV Deletion23290073
    esv2733845CNV Deletion23290073
    esv2140457CNV Deletion18987734
    esv1406872CNV Deletion17803354
    esv2733851CNV Deletion23290073

    Site Specific Mutation Identification with PCR Assays
    Search QIAGEN SeqTarget long-range PCR primers for resequencing EIF3B
    DNA2.0 Custom Variant and Variant Library Synthesis for EIF3B

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 603917    OMIM disorders: --


    Find genes that share disorders with EIF3B           About GenesLikeMe


    Export disorders for EIF3B gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for EIF3B gene, integrated from 10 sources (see all 88):
    (articles sorted by number of sources associating them with EIF3B)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The human homologue of the yeast Prt1 protein is an integral part of the eukaryotic initiation factor 3 complex and interacts with p170. (PubMed id 8995410)1, 2, 3, 9 Methot N.... Sonenberg N. (J. Biol. Chem. 1997)
    2. Molecular interaction between human tumor marker protein p150, the largest subunit of eIF3, and intermediate filament protein K7. (PubMed id 11169732)1, 2, 9 Lin L.... Burger M.M. (J. Cell. Biochem. 2001)
    3. Biochemical characterization of mammalian translation initiation factor 3 (eIF3). Molecular cloning reveals that p110 subunit is the mammalian homologue of Saccharomyces cerevisiae protein Prt1. (PubMed id 9388245)1, 2, 9 Chaudhuri J.... Maitra U. (J. Biol. Chem. 1997)
    4. Mass spectrometry reveals modularity and a complete subunit interaction map of the eukaryotic translation factor eIF3. (PubMed id 18599441)1, 2 Zhou M.... Robinson C.V. (Proc. Natl. Acad. Sci. U.S.A. 2008)
    5. Reconstitution reveals the functional core of mammalian eIF3. (PubMed id 17581632)1, 2 Masutani M.... Imataka H. (EMBO J. 2007)
    6. Structural characterization of the human eukaryotic initiation factor 3 protein complex by mass spectrometry. (PubMed id 17322308)1, 2 Damoc E.... Leary J.A. (Mol. Cell. Proteomics 2007)
    7. Structure of eIF3b RNA recognition motif and its interaction with eIF3j: structural insights into the recruitment of eIF3b to the 40 S ribosomal subunit. (PubMed id 17190833)1, 2 ElAntak L.... Lukavsky P.J. (J. Biol. Chem. 2007)
    8. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)1, 2 Olsen J.V....Mann M. (Cell 2006)
    9. mTOR and S6K1 mediate assembly of the translation preinitiation complex through dynamic protein interchange and ordered phosphorylation events. (PubMed id 16286006)1, 2 Holz M.K.... Blenis J. (Cell 2005)
    10. The j-subunit of human translation initiation factor eIF3 is required for the stable binding of eIF3 and its subcomplexes to 40 S ribosomal subunits in vitro. (PubMed id 14688252)1, 2 Fraser C.S....Hershey J.W.B. (J. Biol. Chem. 2004)

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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 8662 HGNC: 3280 AceView: EIF3S9 Ensembl:ENSG00000106263 euGenes: HUgn8662
    ECgene: EIF3B Kegg: 8662 H-InvDB: EIF3B

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    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for EIF3B Pharmacogenomics, SNPs, Pathways

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