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EIF3B Gene(Protein Coding)

Eukaryotic Translation Initiation Factor 3 Subunit B

GCID:
GC07P002354
GIFtS:
55
Genes Participants
UDN Logo

Aliases for EIF3B Gene

Aliases for EIF3B Gene

  • Eukaryotic Translation Initiation Factor 3 Subunit B 2 3 5
  • Eukaryotic Translation Initiation Factor 3, Subunit 9 Eta, 116kDa 2 3
  • Eukaryotic Translation Initiation Factor 3, Subunit B 2 3
  • Eukaryotic Translation Initiation Factor 3 Subunit 9 3 4
  • Prt1 Homolog 3 4
  • EIF3 P110 3 4
  • EIF3 P116 3 4
  • EIF-3-Eta 3 4
  • EIF3S9 3 4
  • HPrt1 3 4
  • Eukaryotic Translation Initiation Factor 3, Subunit 9 (Eta, 116kD) 3
  • EIF3-P110 3
  • EIF3-P116 3
  • EIF3-ETA 3
  • EIF3b 4
  • PRT1 3

External Ids for EIF3B Gene

Previous HGNC Symbols for EIF3B Gene

  • EIF3S9

Previous GeneCards Identifiers for EIF3B Gene

  • GC07P002362

Summaries for EIF3B Gene

GeneCards Summary for EIF3B Gene

EIF3B (Eukaryotic Translation Initiation Factor 3 Subunit B) is a Protein Coding gene. Among its related pathways are Gene Expression and Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S. GO annotations related to this gene include nucleic acid binding and nucleotide binding.

UniProtKB/Swiss-Prot for EIF3B Gene

  • Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation. In case of FCV infection, plays a role in the ribosomal termination-reinitiation event leading to the translation of VP2 (PubMed:18056426).

Gene Wiki entry for EIF3B Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for EIF3B Gene

Genomics for EIF3B Gene

Products:

  1. Regulatory Element

Regulatory Elements for EIF3B Gene

Enhancers for EIF3B Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around EIF3B on UCSC Golden Path with GeneCards custom track

Promoters for EIF3B Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around EIF3B on UCSC Golden Path with GeneCards custom track

Transcription factor binding sites by QIAGEN in the EIF3B gene promoter:

Genomic Location for EIF3B Gene

Chromosome:
7
Start:
2,354,086 bp from pter
End:
2,380,745 bp from pter
Size:
26,660 bases
Orientation:
Plus strand

Genomic View for EIF3B Gene

Genes around EIF3B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
EIF3B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for EIF3B Gene
GeneLoc Logo Genomic Neighborhood • Exon Structure • Gene Density

RefSeq DNA sequence for EIF3B Gene

Proteins for EIF3B Gene

Products:

  1. Antibody
  2. Protein
  3. Assay

  • Protein details for EIF3B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P55884-EIF3B_HUMAN
    Recommended name:
    Eukaryotic translation initiation factor 3 subunit B
    Protein Accession:
    P55884
    Secondary Accessions:
    • A4D208
    • Q2NL77
    • Q9UMF9

    Protein attributes for EIF3B Gene

    Size:
    814 amino acids
    Molecular mass:
    92482 Da
    Quaternary structure:
    • Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is composed of 13 subunits: EIF3A, EIF3B, EIF3C, EIF3D, EIF3E, EIF3F, EIF3G, EIF3H, EIF3I, EIF3J, EIF3K, EIF3L and EIF3M. The eIF-3 complex appears to include 3 stable modules: module A is composed of EIF3A, EIF3B, EIF3G and EIF3I; module B is composed of EIF3F, EIF3H, and EIF3M; and module C is composed of EIF3C, EIF3D, EIF3E, EIF3K and EIF3L. EIF3C of module C binds EIF3B of module A and EIF3H of module B, thereby linking the three modules. EIF3J is a labile subunit that binds to the eIF-3 complex via EIF3B. The eIF-3 complex interacts with RPS6KB1 under conditions of nutrient depletion. Mitogenic stimulation leads to binding and activation of a complex composed of MTOR and RPTOR, leading to phosphorylation and release of RPS6KB1 and binding of EIF4B to eIF-3. Also interacts with UPF2 and HNRPD.

    Three dimensional structures from OCA and Proteopedia for EIF3B Gene

    Alternative splice isoforms for EIF3B Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for EIF3B Gene

Proteomics data for EIF3B Gene at MOPED

Protein Expression for EIF3B Gene

See protein expression from ProteomicsDB, MOPED, PaxDb, and MaxQB

Post-translational modifications for EIF3B Gene

  • Phosphorylated. Phosphorylation is enhanced upon serum stimulation.
  • Ubiquitination at Lys 209, Lys 230, Lys 257, Lys 288, Lys 324, Lys 345, Lys 364, Lys 516, Lys 535, Lys 552, Lys 604, Lys 718, Lys 729, Lys 744, and Lys 762
  • Modification sites at PhosphoSitePlus

Other Protein References for EIF3B Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for EIF3B Gene

Domains & Families for EIF3B Gene

Gene Families for EIF3B Gene

HGNC:

Protein Domains for EIF3B Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for EIF3B Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P55884

UniProtKB/Swiss-Prot:

EIF3B_HUMAN :
  • The RRM domain mediates interaction with EIF3J.
  • Belongs to the eIF-3 subunit B family.
  • Contains 8 WD repeats.
Domain:
  • The RRM domain mediates interaction with EIF3J.
  • Contains 1 RRM (RNA recognition motif) domain.
Family:
  • Belongs to the eIF-3 subunit B family.
Similarity:
  • Contains 8 WD repeats.
genes like me logo Genes that share domains with EIF3B: view

Function for EIF3B Gene

Products:

  1. Animal Model
  2. CRISPR
  3. miRNA
  4. Inhibitory RNA
  5. Clone
  6. Cell Line
  7. Flow Cytometry

Molecular function for EIF3B Gene

UniProtKB/Swiss-Prot Function:
Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation. In case of FCV infection, plays a role in the ribosomal termination-reinitiation event leading to the translation of VP2 (PubMed:18056426).

Gene Ontology (GO) - Molecular Function for EIF3B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 11169732
GO:0032947 protein complex scaffold TAS 17322308
genes like me logo Genes that share ontologies with EIF3B: view

Phenotypes for EIF3B Gene

MGI mutant phenotypes for EIF3B:
inferred from 1 alleles
GenomeRNAi human phenotypes for EIF3B:
genes like me logo Genes that share phenotypes with EIF3B: view

Animal Models for EIF3B Gene

MGI Knock Outs for EIF3B:

Animal Model Products

miRNA for EIF3B Gene

miRTarBase miRNAs that target EIF3B

Inhibitory RNA Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for EIF3B Gene

Localization for EIF3B Gene

Subcellular locations from UniProtKB/Swiss-Prot for EIF3B Gene

Cytoplasm.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for EIF3B Gene COMPARTMENTS Subcellular localization image for EIF3B gene
Compartment Confidence
cytosol 5
extracellular 5
nucleus 5

Gene Ontology (GO) - Cellular Components for EIF3B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005852 eukaryotic translation initiation factor 3 complex IEA,IDA 8995410
GO:0070062 extracellular exosome IDA 20458337
genes like me logo Genes that share ontologies with EIF3B: view

Pathways & Interactions for EIF3B Gene

genes like me logo Genes that share pathways with EIF3B: view

Gene Ontology (GO) - Biological Process for EIF3B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006413 translational initiation IEA,TAS --
GO:0006446 regulation of translational initiation IDA 8995410
GO:0075522 IRES-dependent viral translational initiation IDA 9573242
genes like me logo Genes that share ontologies with EIF3B: view

No data available for SIGNOR curated interactions for EIF3B Gene

Drugs & Compounds for EIF3B Gene

Products:

  1. Drug
No Compound Related Data Available

Transcripts for EIF3B Gene

Products:

  1. CRISPR
  2. miRNA
  3. Inhibitory RNA
  4. Clone
  5. Flow Cytometry

mRNA/cDNA for EIF3B Gene

(5) REFSEQ mRNAs :
(9) Additional mRNA sequences :
(758) Selected AceView cDNA sequences:
(12) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for EIF3B Gene

Eukaryotic translation initiation factor 3, subunit B:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for EIF3B Gene

ExUns: 1 ^ 2 ^ 3a · 3b · 3c ^ 4a · 4b ^ 5a · 5b ^ 6a · 6b ^ 7a · 7b ^ 8a · 8b ^ 9a · 9b · 9c ^ 10 ^ 11a · 11b ^ 12a · 12b ^ 13 ^ 14 ^ 15a ·
SP1: - - - -
SP2: - - - -
SP3: - - - -
SP4: - - - -
SP5: - - - -
SP6: -
SP7: - - - - - - - - - - - - - -
SP8:
SP9:
SP10: - - -
SP11:
SP12:
SP13: - - - -
SP14:
SP15: -
SP16:
SP17:
SP18: - -

ExUns: 15b · 15c ^ 16 ^ 17a · 17b ^ 18 ^ 19a · 19b · 19c ^ 20a · 20b ^ 21 ^ 22a · 22b ^ 23a · 23b ^ 24a · 24b · 24c
SP1: - - - - - -
SP2: - - - -
SP3: - - - - -
SP4: - - - - -
SP5:
SP6:
SP7: - -
SP8: - -
SP9: - -
SP10:
SP11:
SP12: - - -
SP13:
SP14:
SP15:
SP16:
SP17:
SP18:

Relevant External Links for EIF3B Gene

GeneLoc Exon Structure for
EIF3B
ECgene alternative splicing isoforms for
EIF3B

Expression for EIF3B Gene

Products:

  1. Primer

mRNA expression in normal human tissues for EIF3B Gene

mRNA expression in normal human tissues for EIF3B Gene
mRNA expression by BioGPS for EIF3B GenemRNA expression by GTEx for EIF3B Gene

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for EIF3B Gene



SOURCE GeneReport for Unigene cluster for EIF3B Gene Hs.371001

genes like me logo Genes that share expression patterns with EIF3B: view

Protein tissue co-expression partners for EIF3B Gene

- Elite partner

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for EIF3B Gene

Orthologs for EIF3B Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for EIF3B Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
 Mammalia EIF3B 35
  • 86.98 (n)
  • 91.48 (a)
EIF3B 36
  • 92 (a)
 OneToOne
dog
(Canis familiaris)
 Mammalia EIF3B 35
  • 89.46 (n)
  • 98.8 (a)
EIF3B 36
  • 90 (a)
 OneToOne
mouse
(Mus musculus)
 Mammalia Eif3b 35
  • 85.01 (n)
  • 91.53 (a)
Eif3b 16
Eif3b 36
  • 91 (a)
 OneToOne
chimpanzee
(Pan troglodytes)
 Mammalia EIF3B 35
  • 99.34 (n)
  • 99.26 (a)
EIF3B 36
  • 99 (a)
 OneToOne
rat
(Rattus norvegicus)
 Mammalia Eif3b 35
  • 85.11 (n)
  • 91.97 (a)
oppossum
(Monodelphis domestica)
 Mammalia EIF3B 36
  • 85 (a)
 OneToOne
platypus
(Ornithorhynchus anatinus)
 Mammalia EIF3B 36
  • 98 (a)
 OneToOne
chicken
(Gallus gallus)
 Aves EIF3B 35
  • 78.95 (n)
  • 88.5 (a)
EIF3B 36
  • 86 (a)
 OneToOne
lizard
(Anolis carolinensis)
 Reptilia -- 36
  • 59 (a)
 OneToMany
-- 36
  • 73 (a)
 OneToMany
tropical clawed frog
(Silurana tropicalis)
 Amphibia eif3b 35
  • 77.33 (n)
  • 89.14 (a)
Str.6777 35
African clawed frog
(Xenopus laevis)
 Amphibia Xl.26073 35
zebrafish
(Danio rerio)
 Actinopterygii eif3ba 35
  • 76.93 (n)
  • 86.45 (a)
wufc17c01 35
eif3ba 36
  • 86 (a)
 OneToMany
eif3bb 36
  • 84 (a)
 OneToMany
African malaria mosquito
(Anopheles gambiae)
 Insecta EIF3B_ANOGA 35
  • 56.06 (n)
  • 50.15 (a)
fruit fly
(Drosophila melanogaster)
 Insecta eIF3-S9 35
  • 58.46 (n)
  • 53.67 (a)
eIF3-S9 36
  • 51 (a)
 OneToOne
worm
(Caenorhabditis elegans)
 Secernentea eif-3.B 36
  • 34 (a)
 OneToOne
A. gosspyii yeast
(Ashbya gossypii)
 Saccharomycetes AGOS_ADR399C 35
  • 48.48 (n)
  • 36.86 (a)
K. lactis yeast
(Kluyveromyces lactis)
 Saccharomycetes KLLA0A03531g 35
  • 47.66 (n)
  • 37.5 (a)
baker's yeast
(Saccharomyces cerevisiae)
 Saccharomycetes PRT1 35
  • 48.34 (n)
  • 35.57 (a)
PRT1 36
  • 28 (a)
 OneToOne
PRT1 38
thale cress
(Arabidopsis thaliana)
 eudicotyledons EIF3B-2 35
  • 53.14 (n)
  • 43.26 (a)
rice
(Oryza sativa)
 Liliopsida Os.4899 35
Os10g0569200 35
  • 53.08 (n)
  • 44.36 (a)
sea squirt
(Ciona intestinalis)
 Ascidiacea Cin.3078 35
bread mold
(Neurospora crassa)
 Ascomycetes NCU02208 35
  • 52.57 (n)
  • 43.25 (a)
fission yeast
(Schizosaccharomyces pombe)
 Schizosaccharomycetes SPAC25G10.08 35
  • 49.61 (n)
  • 42.68 (a)
sea squirt
(Ciona savignyi)
 Ascidiacea -- 36
  • 60 (a)
 OneToMany
CSA.6899 36
  • 60 (a)
 OneToMany
Species with no ortholog for EIF3B:
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for EIF3B Gene

ENSEMBL:
Gene Tree for EIF3B (if available)
TreeFam:
Gene Tree for EIF3B (if available)

Paralogs for EIF3B Gene

(1) SIMAP similar genes for EIF3B Gene using alignment to 7 proteins:

genes like me logo Genes that share paralogs with EIF3B: view

No data available for Paralogs for EIF3B Gene

Variants for EIF3B Gene

Sequence variations from dbSNP and Humsavar for EIF3B Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type
rs9690787 - 2,355,111(+) CGGAG(C/T)CCGAG reference, missense
rs1063257 - 2,379,431(+) GACGA(A/C)TGGGA reference, missense
rs883667 -- 2,374,313(+) AATAC(C/T)CCTGT intron-variant
rs884564 -- 2,374,852(-) CAGAC(A/G)GGTCT intron-variant
rs884565 -- 2,374,730(-) GACAC(C/T)GGGGC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for EIF3B Gene

Variant ID Type Subtype PubMed ID
dgv7116n71 CNV Loss 21882294
esv2424013 CNV Deletion 19546169
esv26940 CNV Gain 19812545
dgv227n6 CNV Loss 16902084
esv2733845 CNV Deletion 23290073
esv2733846 CNV Deletion 23290073
esv2663485 CNV Deletion 23128226
esv1406872 CNV Deletion 17803354
dgv1118e201 CNV Deletion 23290073
nsv366196 CNV Loss 16902084
esv2733848 CNV Deletion 23290073
esv2733849 CNV Deletion 23290073
esv2140457 CNV Deletion 18987734
esv2733851 CNV Deletion 23290073

Variation tolerance for EIF3B Gene

Residual Variation Intolerance Score: 7.61% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.55; 55.89% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for EIF3B Gene

Human Gene Mutation Database (HGMD)
EIF3B

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for EIF3B Gene

Disorders for EIF3B Gene

Relevant External Links for EIF3B

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
EIF3B

No disorders were found for EIF3B Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for EIF3B Gene

Publications for EIF3B Gene

  1. The human homologue of the yeast Prt1 protein is an integral part of the eukaryotic initiation factor 3 complex and interacts with p170. (PMID: 8995410) Methot N. … Sonenberg N. (J. Biol. Chem. 1997) 2 3 4 23 67
  2. Molecular interaction between human tumor marker protein p150, the largest subunit of eIF3, and intermediate filament protein K7. (PMID: 11169732) Lin L. … Burger M.M. (J. Cell. Biochem. 2001) 3 23
  3. Biochemical characterization of mammalian translation initiation factor 3 (eIF3). Molecular cloning reveals that p110 subunit is the mammalian homologue of Saccharomyces cerevisiae protein Prt1. (PMID: 9388245) Chaudhuri J. … Maitra U. (J. Biol. Chem. 1997) 3 23
  4. Proteomic analysis and identification of cellular interactors of the giant ubiquitin ligase HERC2. (PMID: 25476789) Galligan J.T. … Howley P.M. (J. Proteome Res. 2015) 3
  5. Temporal proteomics of NGF-TrkA signaling identifies an inhibitory role for the E3 ligase Cbl-b in neuroblastoma cell differentiation. (PMID: 25921289) Emdal K.B. … Olsen J.V. (Sci Signal 2015) 3

Products for EIF3B Gene

Sources for EIF3B Gene

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