Aliases for EIF3B Gene
Aliases for EIF3B Gene
External Ids for EIF3B Gene
- HGNC: 3280
- Entrez Gene: 8662
- Ensembl: ENSG00000106263
- OMIM: 603917
- UniProtKB: P55884
Previous HGNC Symbols for EIF3B Gene
- EIF3S9
Previous GeneCards Identifiers for EIF3B Gene
- GC07P002362
Summaries for EIF3B Gene
GeneCards Summary for EIF3B Gene
EIF3B (Eukaryotic Translation Initiation Factor 3 Subunit B) is a Protein Coding gene. Among its related pathways are Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S and Viral mRNA Translation. Gene Ontology (GO) annotations related to this gene include nucleic acid binding and nucleotide binding.
UniProtKB/Swiss-Prot for EIF3B Gene
-
RNA-binding component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis (PubMed:9388245, PubMed:17581632, PubMed:25849773, PubMed:27462815). The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation (PubMed:9388245, PubMed:17581632). The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, including cell cycling, differentiation and apoptosis, and uses different modes of RNA stem-loop binding to exert either translational activation or repression (PubMed:25849773).
-
(Microbial infection) In case of FCV infection, plays a role in the ribosomal termination-reinitiation event leading to the translation of VP2 (PubMed:18056426).
Additional gene information for EIF3B Gene
- Monarch Initiative
- Search for EIF3B at DataMed
- Search for EIF3B at HumanCyc
No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for EIF3B Gene
Genomics for EIF3B Gene
GeneHancer (GH) Regulatory Elements for EIF3B Gene
Genomic Locations for EIF3B Gene
- chr7:2,354,086-2,380,745
- (GRCh38/hg38)
- Size:
- 26,660 bases
- Orientation:
- Plus strand
- chr7:2,393,721-2,420,380
- (GRCh37/hg19)
Genomic View for EIF3B Gene
- Cytogenetic band:
-
- 7p22.3 by Ensembl
- 7p22.3 by Entrez Gene
- 7p22.3 by HGNC


RefSeq DNA sequence for EIF3B Gene
Proteins for EIF3B Gene
-
Protein details for EIF3B Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- P55884-EIF3B_HUMAN
- Recommended name:
- Eukaryotic translation initiation factor 3 subunit B
- Protein Accession:
- P55884
- A4D208
- Q2NL77
- Q9UMF9
Protein attributes for EIF3B Gene
- Size:
- 814 amino acids
- Molecular mass:
- 92482 Da
- Quaternary structure:
-
- Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is composed of 13 subunits: EIF3A, EIF3B, EIF3C, EIF3D, EIF3E, EIF3F, EIF3G, EIF3H, EIF3I, EIF3J, EIF3K, EIF3L and EIF3M. The eIF-3 complex appears to include 3 stable modules: module A is composed of EIF3A, EIF3B, EIF3G and EIF3I; module B is composed of EIF3F, EIF3H, and EIF3M; and module C is composed of EIF3C, EIF3D, EIF3E, EIF3K and EIF3L. EIF3C of module C binds EIF3B of module A and EIF3H of module B, thereby linking the three modules. EIF3J is a labile subunit that binds to the eIF-3 complex via EIF3B. The eIF-3 complex interacts with RPS6KB1 under conditions of nutrient depletion. Mitogenic stimulation leads to binding and activation of a complex composed of MTOR and RPTOR, leading to phosphorylation and release of RPS6KB1 and binding of EIF4B to eIF-3. Also interacts with UPF2 and HNRPD. Interacts with METTL3 (PubMed:27117702).
Protein Expression for EIF3B Gene
Post-translational modifications for EIF3B Gene
- Phosphorylated. Phosphorylation is enhanced upon serum stimulation.
- Ubiquitination at posLast=209209, posLast=230230, posLast=257257, posLast=288288, Lys324, posLast=345345, Lys364, Lys516, Lys535, posLast=552552, Lys604, posLast=718718, Lys729, posLast=744744, and Lys762
Other Protein References for EIF3B Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
-
Custom Antibody ServicesOriGene Antibodies for EIF3B
- Novus Biologicals Antibodies for EIF3B
-
Abcam antibodies for EIF3B
- Invitrogen Antibodies for EIF3B
- GeneTex EIF3B antibody for EIF3B
-
Santa Cruz Biotechnology (SCBT) Antibodies for EIF3B
Protein Products
-
OriGene Purified Proteins for EIF3B
- Search Origene for MassSpec and Protein Over-expression Lysates for EIF3B
- Origene Custom Protein Services for EIF3B
- Novus Biologicals proteins for EIF3B
- Search GeneTex for Proteins for EIF3B
Assay Products
No data available for DME Specific Peptides for EIF3B Gene
Domains & Families for EIF3B Gene
Gene Families for EIF3B Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Plasma proteins
- Predicted intracellular proteins
Protein Domains for EIF3B Gene
Suggested Antigen Peptide Sequences for EIF3B Gene
Graphical View of Domain Structure for InterPro Entry
P55884UniProtKB/Swiss-Prot:
EIF3B_HUMAN :- The RRM domain mediates interaction with EIF3J.
- Belongs to the eIF-3 subunit B family.
- Domain:
-
- The RRM domain mediates interaction with EIF3J.
- Family:
-
- Belongs to the eIF-3 subunit B family.
Function for EIF3B Gene
Molecular function for EIF3B Gene
- UniProtKB/Swiss-Prot Function:
- RNA-binding component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis (PubMed:9388245, PubMed:17581632, PubMed:25849773, PubMed:27462815). The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation (PubMed:9388245, PubMed:17581632). The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, including cell cycling, differentiation and apoptosis, and uses different modes of RNA stem-loop binding to exert either translational activation or repression (PubMed:25849773).
- UniProtKB/Swiss-Prot Function:
- (Microbial infection) In case of FCV infection, plays a role in the ribosomal termination-reinitiation event leading to the translation of VP2 (PubMed:18056426).
Phenotypes From GWAS Catalog for EIF3B Gene
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0003676 | nucleic acid binding | IEA | -- |
GO:0003723 | RNA binding | IDA | 25849773 |
GO:0003743 | contributes_to translation initiation factor activity | IDA | 17581632 |
GO:0005515 | protein binding | IPI | 11169732 |
GO:0031369 | translation initiation factor binding | IEA | -- |
Phenotypes for EIF3B Gene
- MGI mutant phenotypes for EIF3B:
- inferred from 1 alleles
- GenomeRNAi human phenotypes for EIF3B:
-
- Increased viability
- Increased vaccinia virus (VACV) infection
- Decreased viability
- Decreased ionizing radiation sensitivity
- Decreased NF-kappaB reporter expression
- Increased transferrin (TF) endocytosis
- Negative genetic interaction between PTEN-/- and PTEN+/+
- Nucleoplasmic pre-40S maturation defects
- Nuclear 60S biogenesis defects
- Decreased Aire reporter expression
- Decreased shRNA abundance
- Increased cell death HMECs cells
- Synthetic lethal with vaccinia virus (VACV) infection
- Decreased viability of wild-type and TP53 knockout cells
- Decreased DCP1a protein expression and assembly in processing bodies after arsenite stimulation
Animal Models for EIF3B Gene
- MGI Knock Outs for EIF3B:
-
- Eif3b Gt(GT529)Skmz
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
- Cyagen custom Knockout/knockin (KOKI) mouse models for EIF3B
-
-
ViGene Biosciences lentiviral particle packaged cDNA for EIF3B gene
-
ViGene Biosciences ready-to-package AAV shRNAs for EIF3B gene
- Search ViGene Biosciences for EIF3B
CRISPR Products
-
OriGene CRISPR knockouts for EIF3B
- genomics-online: gRNA clones - Search results for 95 available EIF3B gene related products
- Overview of 95 available EIF3B gene related products
- Applied Biological Materials CRISPR for EIF3B
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for EIF3B
- GenScript: Design CRISPR guide RNA sequences for EIF3B
miRNA for EIF3B Gene
- miRTarBase miRNAs that target EIF3B
miRNA Products
- Search ViGene Biosciences for EIF3B
Inhibitory RNA Products
- Origene RNAi, sirna, and shrna products in human, mouse, rat for EIF3B
- Browse OriGene Inhibitory RNA Products For EIF3B
- genomics-online: shRNA clones - Search results for 95 available EIF3B gene related products
- Overview of 95 available EIF3B gene related products
-
ViGene Biosciences ready-to-package AAV shRNAs for EIF3B gene
Clone Products
- Sino Biological Human cDNA Clone for EIF3B
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- VectorBuilder custom plasmid, inducible vectors for EIF3B
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for EIF3B
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Applied Biological Materials Clones for EIF3B
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
Cell Line Products
-
ViGene Biosciences adenoviral particle packaged cDNA for EIF3B gene
-
ViGene Biosciences lentiviral particle packaged cDNA for EIF3B gene
-
ViGene Biosciences ready-to-package AAV shRNAs for EIF3B gene
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for EIF3B Gene
Localization for EIF3B Gene
Subcellular locations from UniProtKB/Swiss-Prot for EIF3B Gene
- Cytoplasm.
- Cytosol (2)
- Nucleoplasm (2)
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005737 | cytoplasm | IEA | -- |
GO:0005829 | cytosol | TAS | -- |
GO:0005852 | eukaryotic translation initiation factor 3 complex | IDA | 8995410 |
GO:0016282 | eukaryotic 43S preinitiation complex | IEA | -- |
GO:0033290 | eukaryotic 48S preinitiation complex | IEA | -- |
Pathways & Interactions for EIF3B Gene
SuperPathway | Contained pathways | ||
---|---|---|---|
1 | Viral mRNA Translation |
.77
|
|
2 | Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S | ||
3 | RNA transport | ||
4 | Apoptotic Pathways in Synovial Fibroblasts |
.60
|
|
5 | p70S6K Signaling |
.54
|
Pathways by source for EIF3B Gene
1 BioSystems pathway for EIF3B Gene
12 Reactome pathways for EIF3B Gene
1 KEGG pathway for EIF3B Gene
2 Qiagen pathways for EIF3B Gene
Interacting Proteins for EIF3B Gene
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0006412 | translation | IEA | -- |
GO:0006413 | translational initiation | TAS | -- |
GO:0006446 | regulation of translational initiation | IDA | 8995410 |
GO:0075522 | IRES-dependent viral translational initiation | IDA | 9573242 |
GO:0075525 | viral translational termination-reinitiation | IDA | 21347434 |
No data available for SIGNOR curated interactions for EIF3B Gene
Drugs & Compounds for EIF3B Gene
Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
---|---|---|---|---|---|---|
eukaryotic translation initiation factor 3 | Pharma | Eukaryotic translation initiator | 0 |
(1) ApexBio Compounds for EIF3B Gene
Compound | Action | Cas Number |
---|---|---|
eukaryotic translation initiation factor 3 | Eukaryotic translation initiator |
Transcripts for EIF3B Gene
mRNA/cDNA for EIF3B Gene
- (7) REFSEQ mRNAs :
- (9) Additional mRNA sequences :
- (758) Selected AceView cDNA sequences:
- (12) Ensembl transcripts including schematic representations, and UCSC links where relevant :
Unigene Clusters for EIF3B Gene
CRISPR Products
-
OriGene CRISPR knockouts for EIF3B
- genomics-online: gRNA clones - Search results for 95 available EIF3B gene related products
- Overview of 95 available EIF3B gene related products
- Applied Biological Materials CRISPR for EIF3B
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for EIF3B
- GenScript: Design CRISPR guide RNA sequences for EIF3B
miRNA Products
- Search ViGene Biosciences for EIF3B
Inhibitory RNA Products
- Origene RNAi, sirna, and shrna products in human, mouse, rat for EIF3B
- Browse OriGene Inhibitory RNA Products For EIF3B
- genomics-online: shRNA clones - Search results for 95 available EIF3B gene related products
- Overview of 95 available EIF3B gene related products
-
ViGene Biosciences ready-to-package AAV shRNAs for EIF3B gene
Clone Products
- Sino Biological Human cDNA Clone for EIF3B
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- VectorBuilder custom plasmid, inducible vectors for EIF3B
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for EIF3B
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Applied Biological Materials Clones for EIF3B
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
ExUns: | 1 | ^ | 2 | ^ | 3a | · | 3b | · | 3c | ^ | 4a | · | 4b | ^ | 5a | · | 5b | ^ | 6a | · | 6b | ^ | 7a | · | 7b | ^ | 8a | · | 8b | ^ | 9a | · | 9b | · | 9c | ^ | 10 | ^ | 11a | · | 11b | ^ | 12a | · | 12b | ^ | 13 | ^ | 14 | ^ | 15a | · |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
SP1: | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||
SP2: | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||
SP3: | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||
SP4: | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||
SP5: | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||
SP6: | - | |||||||||||||||||||||||||||||||||||||||||||||||||||
SP7: | - | - | - | - | - | - | - | - | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||
SP8: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
SP9: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
SP10: | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||||||
SP11: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
SP12: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
SP13: | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||
SP14: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
SP15: | - | |||||||||||||||||||||||||||||||||||||||||||||||||||
SP16: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
SP17: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
SP18: | - | - |
ExUns: | 15b | · | 15c | ^ | 16 | ^ | 17a | · | 17b | ^ | 18 | ^ | 19a | · | 19b | · | 19c | ^ | 20a | · | 20b | ^ | 21 | ^ | 22a | · | 22b | ^ | 23a | · | 23b | ^ | 24a | · | 24b | · | 24c |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
SP1: | - | - | - | - | - | - | |||||||||||||||||||||||||||||||
SP2: | - | - | - | - | |||||||||||||||||||||||||||||||||
SP3: | - | - | - | - | - | ||||||||||||||||||||||||||||||||
SP4: | - | - | - | - | - | ||||||||||||||||||||||||||||||||
SP5: | |||||||||||||||||||||||||||||||||||||
SP6: | |||||||||||||||||||||||||||||||||||||
SP7: | - | - | |||||||||||||||||||||||||||||||||||
SP8: | - | - | |||||||||||||||||||||||||||||||||||
SP9: | - | - | |||||||||||||||||||||||||||||||||||
SP10: | |||||||||||||||||||||||||||||||||||||
SP11: | |||||||||||||||||||||||||||||||||||||
SP12: | - | - | - | ||||||||||||||||||||||||||||||||||
SP13: | |||||||||||||||||||||||||||||||||||||
SP14: | |||||||||||||||||||||||||||||||||||||
SP15: | |||||||||||||||||||||||||||||||||||||
SP16: | |||||||||||||||||||||||||||||||||||||
SP17: | |||||||||||||||||||||||||||||||||||||
SP18: |
Expression for EIF3B Gene
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for EIF3B Gene
NURSA nuclear receptor signaling pathways regulating expression of EIF3B Gene:
EIF3BSOURCE GeneReport for Unigene cluster for EIF3B Gene:
Hs.371001Evidence on tissue expression from TISSUES for EIF3B Gene
- Nervous system(4.8)
- Liver(4.4)
- Muscle(4.4)
- Intestine(4)
- Skin(3.6)
- Lung(3.5)
- Pancreas(3)
- Eye(2.4)
- Kidney(2.4)
- Spleen(2)
Primer Products
-
OriGene qPCR primer pairs for EIF3B
-
OriGene qPCR primer pairs and template standards for EIF3B
No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for EIF3B Gene
Orthologs for EIF3B Gene
This gene was present in the common ancestor of eukaryotes.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
chimpanzee (Pan troglodytes) |
Mammalia | EIF3B 33 34 |
|
||
platypus (Ornithorhynchus anatinus) |
Mammalia | EIF3B 34 |
|
OneToOne | |
dog (Canis familiaris) |
Mammalia | EIF3B 33 34 |
|
||
cow (Bos Taurus) |
Mammalia | EIF3B 33 34 |
|
||
rat (Rattus norvegicus) |
Mammalia | Eif3b 33 |
|
||
mouse (Mus musculus) |
Mammalia | Eif3b 33 16 34 |
|
||
oppossum (Monodelphis domestica) |
Mammalia | EIF3B 34 |
|
OneToOne | |
chicken (Gallus gallus) |
Aves | EIF3B 33 34 |
|
||
lizard (Anolis carolinensis) |
Reptilia | -- 34 |
|
OneToMany | |
-- 34 |
|
OneToMany | |||
tropical clawed frog (Silurana tropicalis) |
Amphibia | eif3b 33 |
|
||
Str.6777 33 |
|
||||
African clawed frog (Xenopus laevis) |
Amphibia | Xl.26073 33 |
|
||
zebrafish (Danio rerio) |
Actinopterygii | eif3bb 34 |
|
OneToMany | |
eif3ba 33 34 |
|
||||
wufc17c01 33 |
|
||||
fruit fly (Drosophila melanogaster) |
Insecta | eIF3-S9 33 34 |
|
||
African malaria mosquito (Anopheles gambiae) |
Insecta | EIF3B_ANOGA 33 |
|
||
worm (Caenorhabditis elegans) |
Secernentea | eif-3.B 34 |
|
OneToOne | |
A. gosspyii yeast (Ashbya gossypii) |
Saccharomycetes | AGOS_ADR399C 33 |
|
||
baker's yeast (Saccharomyces cerevisiae) |
Saccharomycetes | PRT1 33 34 36 |
|
||
K. lactis yeast (Kluyveromyces lactis) |
Saccharomycetes | KLLA0A03531g 33 |
|
||
thale cress (Arabidopsis thaliana) |
eudicotyledons | EIF3B-2 33 |
|
||
rice (Oryza sativa) |
Liliopsida | Os10g0569200 33 |
|
||
Os.4899 33 |
|
||||
sea squirt (Ciona savignyi) |
Ascidiacea | -- 34 |
|
OneToMany | |
CSA.6899 34 |
|
OneToMany | |||
bread mold (Neurospora crassa) |
Ascomycetes | NCU02208 33 |
|
||
fission yeast (Schizosaccharomyces pombe) |
Schizosaccharomycetes | SPAC25G10.08 33 |
|
||
sea squirt (Ciona intestinalis) |
Ascidiacea | Cin.3078 33 |
|
- Species where no ortholog for EIF3B was found in the sources mined by GeneCards:
-
- Actinobacteria (Mycobacterium tuberculosis)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
Paralogs for EIF3B Gene
(1) SIMAP similar genes for EIF3B Gene using alignment to 7 proteins:
No data available for Paralogs for EIF3B Gene
Variants for EIF3B Gene
SNP ID | Clin | Chr 07 pos | Variation | AA Info | Type |
---|---|---|---|---|---|
rs1000131695 | -- | 2,361,936(+) | C/G | intron_variant | |
rs1000292747 | -- | 2,361,754(+) | C/T | intron_variant | |
rs1000361254 | -- | 2,369,053(+) | C/G | genic_downstream_transcript_variant, intron_variant | |
rs1000569310 | -- | 2,352,884(+) | T/C | upstream_transcript_variant | |
rs1000572141 | -- | 2,353,252(+) | T/A/C | upstream_transcript_variant |
Variant ID | Type | Subtype | PubMed ID |
---|---|---|---|
dgv1071e201 | CNV | deletion | 23290073 |
dgv227n6 | CNV | deletion | 16902084 |
esv1406872 | CNV | deletion | 17803354 |
esv2140457 | CNV | deletion | 18987734 |
esv2424013 | CNV | deletion | 19546169 |
esv2663485 | CNV | deletion | 23128226 |
esv26940 | CNV | gain | 19812545 |
esv2733845 | CNV | deletion | 23290073 |
esv2733846 | CNV | deletion | 23290073 |
esv2733848 | CNV | deletion | 23290073 |
esv2733849 | CNV | deletion | 23290073 |
esv2733851 | CNV | deletion | 23290073 |
esv3541044 | CNV | deletion | 23714750 |
nsv1032737 | CNV | gain | 25217958 |
nsv366196 | CNV | deletion | 16902084 |
nsv950791 | CNV | deletion | 24416366 |
Additional Variant Information for EIF3B Gene
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for EIF3B Gene
Disorders for EIF3B Gene
Additional Disease Information for EIF3B
No disorders were found for EIF3B Gene.
No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for EIF3B Gene
Publications for EIF3B Gene
- The human homologue of the yeast Prt1 protein is an integral part of the eukaryotic initiation factor 3 complex and interacts with p170. (PMID: 8995410) Méthot N … Sonenberg N (The Journal of biological chemistry 1997) 2 3 4 22 58
- Molecular interaction between human tumor marker protein p150, the largest subunit of eIF3, and intermediate filament protein K7. (PMID: 11169732) Lin L … Burger MM (Journal of cellular biochemistry 2001) 3 4 22 58
- Biochemical characterization of mammalian translation initiation factor 3 (eIF3). Molecular cloning reveals that p110 subunit is the mammalian homologue of Saccharomyces cerevisiae protein Prt1. (PMID: 9388245) Chaudhuri J … Maitra U (The Journal of biological chemistry 1997) 3 4 22 58
- eIF3d is an mRNA cap-binding protein that is required for specialized translation initiation. (PMID: 27462815) Lee AS … Cate JH (Nature 2016) 3 4 58
- eIF3 targets cell-proliferation messenger RNAs for translational activation or repression. (PMID: 25849773) Lee AS … Cate JH (Nature 2015) 3 4 58
Products for EIF3B Gene
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- Mammalian expression: PiggyBac
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Sources for EIF3B Gene
- (1) GeneCards
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