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Set Analyses:

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EIF3B Gene

protein-coding GIFtS: 59
GCID: GC07P002362

Eukaryotic Translation Initiation Factor 3, Subunit B

(Previous names: eukaryotic translation initiation factor 3, subunit 9 eta,...)
(Previous symbol: EIF3S9)

See related diseases
at

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(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, ¹⁰fRNAdb, ¹²H-InvDB, ¹³NCBI, ¹⁴NONCODE, and/or ¹⁵RNAdb)
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Aliases
Eukaryotic Translation Initiation Factor 3, Subunit B¹ ²		hPrt1² ³
EIF3S9¹ ² ³ ⁵		PRT1² ⁵
Eukaryotic Translation Initiation Factor 3, Subunit 9 Eta, 116kDa¹ ²		EIF3-ETA²
Eukaryotic Translation Initiation Factor 3 Subunit 9² ³		EIF3-P110²
Prt1 Homolog² ³		EIF3-P116²
eIF-3-eta² ³		Eukaryotic Translation Initiation Factor 3 Subunit B²
EIF3 P110² ³		Eukaryotic Translation Initiation Factor 3, Subunit 9 (Eta, 116kD)²
EIF3 P116² ³		eIF3b³

External Ids:	HGNC: 3280¹	Entrez Gene: 8662²	Ensembl: ENSG00000106263⁷	OMIM: 603917⁵	UniProtKB: P55884³

Export aliases for EIF3B gene to outside databases

(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for EIF3B Gene:

EIF3B (eukaryotic translation initiation factor 3, subunit B) is a protein-coding gene. Diseases associated with EIF3B include mouth disease, and tetralogy of fallot. GO annotations related to this gene include protein complex scaffold and nucleotide binding.

UniProtKB/Swiss-Prot: EIF3B_HUMAN, P55884

Function: Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for

several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and

facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S preinitiation

complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG

recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal

complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation

Gene Wiki entry for EIF3B Gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:

NC_000007.14 NC_018918.2 NT_007819.18

Regulatory elements:

Regulatory transcription factor binding sites in the EIF3B gene promoter:
Max1 Pax-5 NF-E2 p45 Egr-4 AREB6 Pax-4a NF-E2 ATF ATF6 c-Myc
Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 11): EIF3B promoter sequence

Search Chromatin IP Primers for EIF3B

Epigenetics:

DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat EIF3B

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 7p22.3 Ensembl cytogenetic band: 7p22.3 HGNC cytogenetic band: 7p22

EIF3B Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
EIF3B gene location

GeneLoc information about chromosome 7 GeneLoc Exon Structure

GeneLoc location for GC07P002362: view genomic region (about GC identifiers)

Start:	2,393,721 bp from pter	End:	2,420,380 bp from pter
Size:	26,660 bases	Orientation:	plus strand

1 alternative location:

Chr7+,CRA_TCAG 2,442,541-2,468,274

(According to ¹UniProtKB, HORDE, ²neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: EIF3B_HUMAN, P55884 (See protein sequence)

Recommended Name: Eukaryotic translation initiation factor 3 subunit B

Size: 814 amino acids; 92482 Da

Subunit: Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is composed of 13

subunits: EIF3A, EIF3B, EIF3C, EIF3D, EIF3E, EIF3F, EIF3G, EIF3H, EIF3I, EIF3J, EIF3K, EIF3L and EIF3M. The eIF-3

complex appears to include 3 stable modules: module A is composed of EIF3A, EIF3B, EIF3G and EIF3I; module B is

composed of EIF3F, EIF3H, and EIF3M; and module C is composed of EIF3C, EIF3D, EIF3E, EIF3K and EIF3L. EIF3C of

module C binds EIF3B of module A and EIF3H of module B, thereby linking the three modules. EIF3J is a labile

subunit that binds to the eIF-3 complex via EIF3B. The eIF-3 complex interacts with RPS6KB1 under conditions of

nutrient depletion. Mitogenic stimulation leads to binding and activation of a complex composed of MTOR and

RPTOR, leading to phosphorylation and release of RPS6KB1 and binding of EIF4B to eIF-3. Also interacts with UPF2

Mass spectrometry: Mass=93093.7; Method=Unknown; Range=1-814; Source=PubMed:17322308;

Mass spectrometry: Mass=92561; Mass_error=43.5; Method=MALDI; Range=1-814; Source=PubMed:18599441;

2 PDB 3D structures from and Proteopedia for EIF3B:

2KRB (3D)

2NLW (3D)

Secondary accessions: A4D208 Q2NL77 Q9UMF9

Alternative splicing: 2 isoforms: P55884-1 P55884-2

Explore the universe of human proteins at neXtProt for EIF3B: NX_P55884

Explore proteomics data for EIF3B at MOPED

Post-translational modifications:

Phosphorylated. Phosphorylation is enhanced upon serum stimulation¹

Ubiquitination² at Lys209, Lys230, Lys257, Lys288, Lys324, Lys345, Lys364, Lys516, Lys535, Lys552,
Lys604, Lys718, Lys729, Lys744, Lys762

Modification sites at PhosphoSitePlus

See EIF3B Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

REFSEQ proteins (2 alternative transcripts):

NP_001032360.1 NP_003742.2

ENSEMBL proteins:

ENSP00000408062 ENSP00000354125 ENSP00000407785 ENSP00000380206

Reactome Protein details: P55884

EIF3B Human Recombinant Protein Products:

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	Browse ProSpec Recombinant Proteins
	Cloud-Clone Corp. Proteins for EIF3B

EIF3B Antibody Products:

	Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
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	Search for Antibodies for EIF3B at Abcam
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	ThermoFisher Antibodies for EIF3B
	LSBio Antibodies in human, mouse, rat for EIF3B

EIF3B Assay Products:

	Browse Kits and Assays available from EMD Millipore
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	Cloud-Clone Corp. ELISAs for EIF3B Cloud-Clone Corp. CLIAs for EIF3B

(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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HGNC Gene Families:

RBM: RNA binding motif (RRM) containing

5 InterPro protein domains:

IPR013979 TIF_beta_prop-like

IPR000504 RRM_dom

IPR012677 Nucleotide-bd_a/b_plait

IPR015943 WD40/YVTN_repeat-like_dom

IPR011400 EIF3B

Graphical View of Domain Structure for InterPro Entry P55884

ProtoNet protein and cluster: P55884

2 Blocks protein domains:

IPB000504 RNA-binding region RNP-1 (RNA recognition motif)

IPB013979 Eukaryotic translation initiation factor 2A

UniProtKB/Swiss-Prot: EIF3B_HUMAN, P55884

Domain: The RRM domain mediates interaction with EIF3J

Similarity: Belongs to the eIF-3 subunit B family

Similarity: Contains 1 RRM (RNA recognition motif) domain

Similarity: Contains 5 WD repeats

EIF3B for domains About GeneDecksing

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Molecular Function:

UniProtKB/Swiss-Prot Summary: EIF3B_HUMAN, P55884

Function: Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for

several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and

facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S preinitiation

complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG

recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal

complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation

Gene Ontology (GO): Selected molecular function terms (see all 7): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0000166	nucleotide binding	IEA	--
GO:0003676	nucleic acid binding	--	--
GO:0003723	RNA binding	--	--
GO:0003743	contributes to translation initiation factor activity	IDA	17581632
GO:0005515	protein binding	IPI	11169732

EIF3B for ontologies About GeneDecksing

Phenotypes:
5 GenomeRNAi human phenotypes for EIF3B:

Decreased G3BP1 protein expres	Decreased viability of wild-ty	Increased cell death in HCT116	Nuclear 60S biogenesis defects
Nucleolar pre-40S maturation d

Animal Models:

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genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for EIF3B

genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for EIF3B

miRNA Products:		miRTarBase miRNAs that target EIF3B: hsa-mir-151a-3p (MIRT043600), hsa-mir-92a-3p (MIRT049064), hsa-mir-615-3p (MIRT039779), hsa-mir-877-3p (MIRT036964), hsa-mir-222-3p (MIRT046746), hsa-mir-423-3p (MIRT042468), hsa-mir-324-3p (MIRT042887), hsa-mir-124-3p (MIRT022932)

		Block miRNA regulation of human, mouse, rat EIF3B using miScript Target Protectors
		6 qRT-PCR Assays for microRNAs that regulate EIF3B:
		hsa-miR-3140-3p hsa-miR-124 hsa-miR-198 hsa-miR-525-5p hsa-miR-506 hsa-miR-520a-5p
		SwitchGear 3'UTR luciferase reporter plasmid: EIF3B 3' UTR sequence

Inhib. RNA Products:		OriGene RNAi products in human, mouse, rat for EIF3B
		Predesigned siRNA for gene silencing in human, mouse, rat EIF3B

Gene Editing
Products:

DNA2.0 Custom Protein Engineering Service for EIF3B

Clone Products:		OriGene clones in human, mouse for EIF3B (see all 12) OriGene ORF clones in mouse, rat for EIF3B OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector (see all 2): EIF3B (NM_003751)
		Browse Sino Biological Human cDNA Clones
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for EIF3B
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat EIF3B

Cell Line Products:		GenScript Custom overexpressing Cell Line Services for EIF3B
		Browse ESI BIO Cell Lines and PureStem Progenitors for EIF3B

In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for EIF3B

(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Subcellular locations from UniProtKB/Swiss-Prot

EIF3B_HUMAN, P55884: Cytoplasm (By similarity)

Subcellular locations from COMPARTMENTS:

Compartment	Confidence
cytosol	4
nucleus	3

About this image

Gene Ontology (GO): 5 cellular component terms: About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005829	cytosol	TAS	--
GO:0005852	eukaryotic translation initiation factor 3 complex	IDA	17322308
GO:0016282	eukaryotic 43S preinitiation complex	IEA	--
GO:0033290	eukaryotic 48S preinitiation complex	IEA	--
GO:0070062	extracellular vesicular exosome	IDA	--

EIF3B for ontologies About GeneDecksing

(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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SuperPaths for EIF3B About (see all 6)

See pathways by source

SuperPath

Contained pathways About

Influenza Viral RNA Transcription and Replication

L13a-mediated translational silencing of Ceruloplasmin expression	0.94	Cap-dependent Translation Initiation	0.89
Formation of a pool of free 40S subunits	0.94	Eukaryotic Translation Initiation	0.89
GTP hydrolysis and joining of the 60S ribosomal subunit	0.93	Translation	0.82

Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S

	Translation initiation complex formation	0.91			Formation of the ternary complex, and subsequently, the 43S complex	0.91
	Ribosomal scanning and start codon recognition	0.91			Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S	0.90

Gene Expression

Gene Expression

0.40

Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein

Metabolism of proteins

0.30

Translation Factors

Translation Factors

Pathways by source See SuperPaths
Show all pathways

2 Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for EIF3B

	eIF2 Pathway
	mTOR Pathway

1 BioSystems Pathway for EIF3B

Translation Factors

Selected Reactome Pathways for EIF3B (see all 6)

	Formation of the ternary complex, and subsequently, the 43S complex
	L13a-mediated translational silencing of Ceruloplasmin expression
	GTP hydrolysis and joining of the 60S ribosomal subunit
	Ribosomal scanning and start codon recognition
	Formation of a pool of free 40S subunits

1 Kegg Pathway (Kegg details for EIF3B):

RNA transport

EIF3B for pathways About GeneDecksing

Custom Pathway & Disease-focused RT² Profiler PCR Arrays for EIF3B
Interactions:

Search GeneGlobe Interaction Network for EIF3B

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

Selected Interacting proteins for EIF3B (P55884^{1, 2, 3} ENSP00000354125⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 843)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
HIST1H4A	P62805³	I2D: score=1
HIST1H4B	P62805³	I2D: score=1
HIST1H4C	P62805³	I2D: score=1
HIST1H4D	P62805³	I2D: score=1
HIST1H4E	P62805³	I2D: score=1

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Gene Ontology (GO): Selected biological process terms (see all 6): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0001731	formation of translation preinitiation complex	IEA	--
GO:0006412	translation	TAS	--
GO:0006413	translational initiation	TAS	--
GO:0006446	regulation of translational initiation	IDA	8995410
GO:0010467	gene expression	TAS	--

EIF3B for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse compounds at ApexBio

Browse Tocris compounds for EIF3B

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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REFSEQ mRNAs for EIF3B gene (2 alternative transcripts):

NM_001037283.1 NM_003751.3

Unigene Cluster for EIF3B:

Eukaryotic translation initiation factor 3, subunit B

Hs.371001 [show with all ESTs]

Unigene Representative Sequence: AB209381

12 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000431643 ENST00000360876(uc003slx.3 uc003sly.3 uc003slz.1)

ENST00000413917 ENST00000397011(uc003sma.3) ENST00000463229 ENST00000463026

ENST00000468250 ENST00000466199 ENST00000475415 ENST00000468611(uc003smb.3)

ENST00000465670 ENST00000494658

miRNA Products:		Block miRNA regulation of human, mouse, rat EIF3B using miScript Target Protectors
		6 qRT-PCR Assays for microRNAs that regulate EIF3B:
		hsa-miR-3140-3p hsa-miR-124 hsa-miR-198 hsa-miR-525-5p hsa-miR-506 hsa-miR-520a-5p
		SwitchGear 3'UTR luciferase reporter plasmid: EIF3B 3' UTR sequence

Inhib. RNA Products:		OriGene RNAi products in human, mouse, rat for EIF3B
		Predesigned siRNA for gene silencing in human, mouse, rat EIF3B

Clone Products:		OriGene clones in human, mouse for EIF3B (see all 12) OriGene ORF clones in mouse, rat for EIF3B OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector (see all 2): EIF3B (NM_003751)
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for EIF3B
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat EIF3B

Primer Products:		OriGene qPCR primer pairs and template standards for EIF3B OriGene qSTAR qPCR primer pairs in human, mouse for EIF3B
		Pre-validated RT² qPCR Primer Assay in human, mouse, rat EIF3B
		QuantiTect SYBR Green Assays in human, mouse, rat EIF3B
		QuantiFast Probe-based Assays in human, mouse, rat EIF3B

Additional mRNA sequence:

AB209381.1 AK127885.1 AK300967.1 AK302058.1 BC001173.1 BC009986.1 BC110865.1 U62583.1

U78525.1

Selected DOTS entries (see all 35):

DT.100834695 DT.97798019 DT.100759692 DT.95173385 DT.100834690 DT.454061 DT.100730058 DT.429116

DT.92462641 DT.97786597 DT.203336 DT.70104982 DT.102836765 DT.100039603 DT.95305235 DT.95148198

DT.97864515 DT.121124337 DT.95313948 DT.100834693 DT.121124353 DT.100033517 DT.100834684 DT.100834692

Selected AceView cDNA sequences (see all 758):

BM919002 BC001173 AI204368 AI699769 AW613698 BU857372 CF131575 BQ184896

AU124102 BM790290 AW189503 BU742454 CD360052 CB158647 BQ430432 CA414423

BU179964 BU729506 BF813415 BM459410 BU520863 BG392270 BQ221471 AI677741

GeneLoc Exon Structure

18 Alternative Splicing Database (ASD) splice patterns (SP) for EIF3B (see first 5) About this scheme

ExUns:	1	^	2	^	3a	·	3b	·	3c	^	4a	·	4b	^	5a	·	5b	^	6a	·	6b	^	7a	·	7b	^	8a	·	8b	^	9a	·	9b	·	9c	^	10	^	11a	·	11b	^	12a	·	12b	^	13	^	14	^	15a	·
SP1:																															-										-				-		-
SP2:																															-										-				-		-
SP3:																															-										-				-		-
SP4:																															-										-				-		-
SP5:			-		-		-		-
SP6:									-
SP7:																									-		-		-		-		-		-		-		-		-		-		-		-		-		-
SP8:
SP9:
SP10:																																									-				-		-
SP11:
SP12:
SP13:					-		-		-		-
SP14:
SP15:																																									-
SP16:
SP17:
SP18:															-		-

ExUns:	15b	·	15c	^	16	^	17a	·	17b	^	18	^	19a	·	19b	·	19c	^	20a	·	20b	^	21	^	22a	·	22b	^	23a	·	23b	^	24a	·	24b	·	24c
SP1:			-				-						-														-		-				-
SP2:			-				-						-														-
SP3:			-				-						-														-		-
SP4:			-				-						-														-		-
SP5:
SP6:
SP7:			-				-
SP8:													-														-
SP9:																											-		-
SP10:
SP11:
SP12:																											-		-		-
SP13:
SP14:
SP15:
SP16:
SP17:
SP18:

ECgene alternative splicing isoforms for EIF3B

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE ¹MOPED, ²PaxDb, and ³MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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EIF3B expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>^2/3
CGAP TAG: GAAATAAAAG

About this image

EIF3B expression in embryonic tissues and stem cells About this table

Data from LifeMap, the Embryonic Development and Stem Cells Database
selected tissues (see all 13) fully expand


Brain (Nervous System) fully expand to see all 4 entries
Cerebral Cortex

Ovary (Reproductive System) fully expand to see all 2 entries
Ovarian Mesenchymal Stroma Cells Ovary Interstitium
Oviduct

Testis (Reproductive System)
Leydig Cells Testis Interstitium

Bone (Muscoskeletal System)
Bone Marrow

Trophoblast (Extraembryonic Tissues)
Trophoblast Cells Trophoblast

EIF3B Protein expression data from MOPED¹, PaxDb² and MaxQB³:

About this image

EIF3B Protein Expression

SOURCE GeneReport for Unigene cluster: Hs.371001

Custom PCR Arrays for EIF3B

Primer Products:		OriGene qPCR primer pairs and template standards for EIF3B OriGene qSTAR qPCR primer pairs in human, mouse for EIF3B
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(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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This gene was present in the common ancestor of eukaryotes.

Orthologs for EIF3B gene from Selected species (see all 25) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
mouse (Mus musculus)	Mammalia	Eif3b^{1 , 5}	eukaryotic translation initiation factor 3, subunit more^{1, 5}	85.01(n)¹ 91.53(a)¹		5 (78.97 cM)⁵ 27979¹ NM_133916.2¹ NP_598677.1¹ 140419305⁵
chicken (Gallus gallus)	Aves	EIF3B¹	eukaryotic translation initiation factor 3, subunit more	78.95(n) 88.5(a)		769783 XM_003642142.2 XP_003642190.2
lizard (Anolis carolinensis)	Reptilia	-- --	Uncharacterized protein	73(a) 59(a)	many → 1 many → 1	GL343340.1(41712-52758) GL343307.1(1301747-1303336)
African clawed frog (Xenopus laevis)	Amphibia	Xl.26073²	Xenopus laevis transcribed sequence with moderate similarity more	77.37(n)		48055327
zebrafish (Danio rerio)	Actinopterygii	wufc17c01²	wufc17c01	82.82(n)		324028 CA787533.1
fruit fly (Drosophila melanogaster)	Insecta	eIF3-S9¹	eIF3-S9	58.46(n) 53.67(a)		36981 NM_166239.3 NP_725691.1
worm (Caenorhabditis elegans)	Secernentea	eif-3.B⁶	Protein EIF-3.B, isoform a	34(a)	1 ↔ 1	II(14795404-14798234) WBGene00001225
baker's yeast (Saccharomyces cerevisiae)	Saccharomycetes	PRT1(YOR361C)⁴ PRT1¹	eIF3b subunit of the core complex of translation initiation more⁴ PRT1¹	48.34(n)¹ 35.57(a)¹		15(1017652-1015361)⁴ 854543^{1, 4} NP_015006.3¹ NP_015006.1⁴
thale cress (Arabidopsis thaliana)	eudicotyledons	EIF3B-2¹	EIF3B-2	53.14(n) 43.26(a)		832647 NM_122479.3 NP_568477.1
rice (Oryza sativa)	Liliopsida	Os.4899²	Oryza sativa (japonica cultivar-group) cDNA clone0 more	70.36(n)		AK110143.1

ENSEMBL Gene Tree for EIF3B (if available)
TreeFam Gene Tree for EIF3B (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
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Paralogs for EIF3B gene

1 SIMAP similar gene for EIF3B using alignment to 7 protein entries: EIF3B_HUMAN (see all proteins):

EIF3S9

EIF3B for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, ⁴UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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SNP ID	Valid	Clinical significance	Chr 7 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs7795937^1,2	C	--	2392502(+)	`cttatC/Tgtaca`	2	--	us2k¹		0	--	--	--	--
rs186644527^1,2		--	2392544(+)	`ACCTGC/TCCAAA`	2	--	us2k¹		0	--	--	--	--
rs191108917^1,2	C	--	2392571(+)	`CATGAC/TGAGGA`	2	--	us2k¹		0	--	--	--	--
rs140573262^1,2		--	2392678(+)	`AGTCCC/TGGCAC`	2	--	us2k¹		0	--	--	--	--
rs74934372^1,2	F	--	2392748(+)	`ACACAG/ATGAGA`	2	--	us2k¹		1		NA	120
rs145735770^1,2		--	2392785(+)	`TGGGCA/GCGGTG`	2	--	us2k¹		0	--	--	--	--
rs62444162^1,2	C,F	--	2392860(+)	`GCATAT/CTAAAA`	2	--	us2k¹		2		NA	122
rs182566997^1,2		--	2392876(+)	`AGGCCC/GTGCGC`	2	--	us2k¹		0	--	--	--	--
rs141855682^1,2		--	2392881(+)	`CTGCGC/GGGTGG`	2	--	us2k¹		0	--	--	--	--
rs7792934^1,2	C,F	--	2393016(+)	`accctG/Atctct`	2	--	us2k¹		12		NA WA CSA EA	374

HapMap Linkage Disequilibrium report for EIF3B (2393721 - 2420380 bp)

Structural Variations
Database of Genomic Variants (DGV) Selected variations for EIF3B (see all 14): About this table

Variant ID	Type	Subtype	PubMed ID
esv2733848	CNV	Deletion	23290073
esv2663485	CNV	Deletion	23128226
dgv1118e201	CNV	Deletion	23290073
esv2424013	CNV	Deletion	19546169
esv2733846	CNV	Deletion	23290073
esv2733849	CNV	Deletion	23290073
esv2733845	CNV	Deletion	23290073
esv2140457	CNV	Deletion	18987734
esv1406872	CNV	Deletion	17803354
esv2733851	CNV	Deletion	23290073

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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OMIM gene information: 603917 OMIM disorders: --

5 diseases for EIF3B:
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mouth disease tetralogy of fallot melanoma hiv-1

malaria

EIF3B for disorders About GeneDecksing

Export disorders for EIF3B gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
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PubMed articles for EIF3B gene, integrated from 10 sources (see all 88):
(articles sorted by number of sources associating them with EIF3B)

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The human homologue of the yeast Prt1 protein is an integral part of the eukaryotic initiation factor 3 complex and interacts with p170. (PubMed id 8995410)^{1, 2, 3, 9} Methot N.... Sonenberg N. (J. Biol. Chem. 1997)
Molecular interaction between human tumor marker protein p150, the largest subunit of eIF3, and intermediate filament protein K7. (PubMed id 11169732)^{1, 2, 9} Lin L.... Burger M.M. (J. Cell. Biochem. 2001)
Biochemical characterization of mammalian translation initiation factor 3 (eIF3). Molecular cloning reveals that p110 subunit is the mammalian homologue of Saccharomyces cerevisiae protein Prt1. (PubMed id 9388245)^{1, 2, 9} Chaudhuri J.... Maitra U. (J. Biol. Chem. 1997)
Mass spectrometry reveals modularity and a complete subunit interaction map of the eukaryotic translation factor eIF3. (PubMed id 18599441)^{1, 2} Zhou M.... Robinson C.V. (Proc. Natl. Acad. Sci. U.S.A. 2008)
Reconstitution reveals the functional core of mammalian eIF3. (PubMed id 17581632)^{1, 2} Masutani M.... Imataka H. (EMBO J. 2007)
Structural characterization of the human eukaryotic initiation factor 3 protein complex by mass spectrometry. (PubMed id 17322308)^{1, 2} Damoc E.... Leary J.A. (Mol. Cell. Proteomics 2007)
Structure of eIF3b RNA recognition motif and its interaction with eIF3j: structural insights into the recruitment of eIF3b to the 40 S ribosomal subunit. (PubMed id 17190833)^{1, 2} ElAntak L.... Lukavsky P.J. (J. Biol. Chem. 2007)
Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)^{1, 2} Olsen J.V....Mann M. (Cell 2006)
mTOR and S6K1 mediate assembly of the translation preinitiation complex through dynamic protein interchange and ordered phosphorylation events. (PubMed id 16286006)^{1, 2} Holz M.K.... Blenis J. (Cell 2005)
The j-subunit of human translation initiation factor eIF3 is required for the stable binding of eIF3 and its subcomplexes to 40 S ribosomal subunits in vitro. (PubMed id 14688252)^{1, 2} Fraser C.S....Hershey J.W.B. (J. Biol. Chem. 2004)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 8662	HGNC: 3280	AceView: EIF3S9	Ensembl:ENSG00000106263	euGenes: HUgn8662
ECgene: EIF3B	Kegg: 8662	H-InvDB: EIF3B

(According to HUGE)
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(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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Name	Description
PharmGKB entry for EIF3B	Pharmacogenomics, SNPs, Pathways

Intellectual Property for EIF3B gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

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Patent Information for EIF3B gene:
Search GeneIP for patents involving EIF3B

GeneCards and IP:
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EIF3B Gene

Eukaryotic Translation Initiation Factor 3, Subunit B

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EIF3B Gene

Eukaryotic Translation Initiation Factor 3, Subunit B

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