EIF3B Gene
protein-coding GIFtS: 57
GCID: GC07P002362
|
|
eukaryotic translation initiation factor 3, subunit B(Previous names: eukaryotic translation initiation factor 3, subunit 9 eta,...)
(Previous symbol: EIF3S9)
| |
Aliases
for EIF3B gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Eukaryotic Translation Initiation Factor 3, Subunit B1 2 | | EIF3 P1102 3 | | EIF3S91 2 3 5 | | EIF3 P1162 3 | | PRT11 2 5 | | HPrt11 | | Eukaryotic Translation Initiation Factor 3, Subunit 9 Eta, 116kDa1 2 | | EIF3-ETA2 | | EIF3b1 | | EIF3-P1102 | | Eukaryotic Translation Initiation Factor 3 Subunit 92 3 | | EIF3-P1162 | | Prt1 Homolog2 3 | | Eukaryotic Translation Initiation Factor 3 Subunit B2 | | EIF-3-Eta1 | | Eukaryotic Translation Initiation Factor 3, Subunit 9 (Eta, 116kD)2 |
Export aliases for EIF3B gene to outside databases |
Summaries
for EIF3B gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
UniProtKB/Swiss-Prot: EIF3B_HUMAN, P55884Function: Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for severalsteps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and facilitates therecruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S preinitiation complex (43S PIC). TheeIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequentlyprevents premature joining of the 40S and 60S ribosomal subunits prior to initiation
Gene Wiki entry for EIF3B
|
Genomic Views
for EIF3B gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000007.13 NC_018918.1 NT_007819.17 NT_079592.2
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the EIF3B gene promoter:
Max1 Pax-5 NF-E2 p45 Egr-4 AREB6 Pax-4a NF-E2 ATF ATF6 c-Myc
Other transcription factors
Search SABiosciences Chromatin IP Primers for EIF3B
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat EIF3B |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 7p22.3 Ensembl cytogenetic band: 7p22.3 HGNC cytogenetic band: 7p22EIF3B Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 7 GeneLoc Exon Structure GeneLoc location for GC07P002362: view genomic region
(about GC identifiers)
Start:
|
2,393,721 bp from pter |
End:
|
2,420,380 bp from pter |
Size:
|
26,660 bases |
Orientation:
|
plus strand |
1 alternative location:
| Chr7+,CRA_TCAG 2,442,541-2,468,274 |
|
Proteins
for EIF3B gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: EIF3B_HUMAN, P55884 (See
protein sequence)Recommended Name: Eukaryotic translation initiation factor 3 subunit B Size: 814 amino acids; 92482 Da
Subunit: Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is composed of 13 subunits:EIF3A, EIF3B, EIF3C, EIF3D, EIF3E, EIF3F, EIF3G, EIF3H, EIF3I, EIF3J, EIF3K, EIF3L and EIF3M. The eIF-3 complexappears to include 3 stable modules: module A is composed of EIF3A, EIF3B, EIF3G and EIF3I; module B is composed ofEIF3F, EIF3H, and EIF3M; and module C is composed of EIF3C, EIF3D, EIF3E, EIF3K and EIF3L. EIF3C of module C bindsEIF3B of module A and EIF3H of module B, thereby linking the three modules. EIF3J is a labile subunit that binds tothe eIF-3 complex via EIF3B. The eIF-3 complex interacts with RPS6KB1 under conditions of nutrient depletion.Mitogenic stimulation leads to binding and activation of a complex composed of MTOR and RPTOR, leading tophosphorylation and release of RPS6KB1 and binding of EIF4B to eIF-3. Also interacts with UPF2
Subcellular location: Cytoplasm (By similarity)
Mass spectrometry: Mass=93093.7; Method=Unknown; Range=1-814; Source=PubMed:17322308;
Mass spectrometry: Mass=92561; Mass_error=43.5; Method=MALDI; Range=1-814; Source=PubMed:18599441;
2 PDB 3D structures from  and Proteopedia  for EIF3B:2KRB (3D)
2NLW (3D)
Secondary accessions: A4D208 Q2NL77 Q9UMF9Alternative splicing: 2 isoforms: P55884-1 P55884-2 Explore the universe of human proteins at neXtProt for EIF3B: NX_P55884
Post-translational modifications:
Phosphorylated. Phosphorylation is enhanced upon serum stimulation1
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_P55884
EIF3B Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins (2 alternative transcripts):
NP_001032360.1 NP_003742.2
ENSEMBL proteins: ENSP00000408062 ENSP00000354125 ENSP00000407785 ENSP00000380206 Reactome Protein details: P55884
Human Recombinant Protein Products:
Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view): About this table
EIF3B for ontologies About GeneDecksing
EIF3B Antibody Products:
Assay Products for EIF3B: |
Protein
Domains /
Families
for EIF3B gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
EIF3B for domains About GeneDecksing
5 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry P55884ProtoNet protein and cluster: P55884 2 Blocks protein families: IPB000504 RNA-binding region RNP-1 (RNA recognition motif) IPB013979 Eukaryotic translation initiation factor 2A
UniProtKB/Swiss-Prot: EIF3B_HUMAN, P55884Domain: The RRM domain mediates interaction with EIF3JSimilarity: Belongs to the eIF-3 subunit B familySimilarity: Contains 1 RRM (RNA recognition motif) domainSimilarity: Contains 5 WD repeats |
Function
for EIF3B gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: EIF3B_HUMAN, P55884Function: Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for severalsteps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and facilitates therecruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S preinitiation complex (43S PIC). TheeIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequentlyprevents premature joining of the 40S and 60S ribosomal subunits prior to initiation
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for EIF3B (see all 4)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for EIF3B (see all 3)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector (see all 2): EIF3B (NM_003751) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for EIF3B | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat EIF3B |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for EIF3B |
Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view): About this table
EIF3B for ontologies About GeneDecksing
5 GenomeRNAi human phenotypes for EIF3B:
|
Pathways & Interactions
for EIF3B gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways - 5/7 super-pathways (see all 7) About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | Synthesis of PB1-F2 | | | 2 | Translation initiation complex formation | | | 3 | IL-2 Signaling Pathway | | | 4 | Translation Factors | | | 5 | RNA transport | |
Pathway sources
See GeneCards unified pathways
Show all pathways
2  BioSystems Pathways for EIF3B
5/13 
Reactome Pathways for EIF3B (see all 13)
1 
Kegg Pathway (Kegg details for EIF3B):
EIF3B for pathways About GeneDecksing
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for EIF3B
STRING Interaction
Network Preview (showing 5 interactants - click image to see 25)
5/735 Interacting proteins for EIF3B (P558841, 2, 3 ENSP000003541254) via UniProtKB, MINT, STRING, and/or I2D (see all 735)About this table
Gene Ontology (GO): 5 biological process terms (GO ID links to tree view): About this table
EIF3B for ontologies About GeneDecksing
|
Drugs & Compounds
for EIF3B gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for EIF3B
Search CenterWatch for drugs/clinical trials and news about EIF3B
|
Transcripts
for EIF3B gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for EIF3B gene (2 alternative transcripts): NM_001037283.1 NM_003751.3 Unigene Cluster for EIF3B: Eukaryotic translation initiation factor 3, subunit B Hs.371001 [show with all ESTs]Unigene Representative Sequence: AB20938112 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000431643 ENST00000360876(uc003slx.3 uc003sly.3 uc003slz.1)
ENST00000413917 ENST00000397011(uc003sma.3) ENST00000463229 ENST00000463026
ENST00000468250 ENST00000466199 ENST00000475415 ENST00000468611(uc003smb.3)
ENST00000465670 ENST00000494658
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for EIF3B (see all 4)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for EIF3B (see all 3)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector (see all 2): EIF3B (NM_003751) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for EIF3B | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat EIF3B |
Additional cDNA sequence: AB209381.1 AK127885.1 AK300967.1 AK302058.1 BC001173.1 BC009986.1 BC110865.1 U62583.1 U78525.1 24/35 DOTS entries (see all 35): DT.100834695 DT.97798019 DT.100759692 DT.95173385 DT.100834690 DT.454061 DT.100730058 DT.429116 DT.92462641 DT.97786597 DT.203336 DT.70104982 DT.102836765 DT.100039603 DT.95305235 DT.95148198 DT.97864515 DT.121124337 DT.95313948 DT.100834693 DT.121124353 DT.100033517 DT.100834684 DT.100834692 24/758 AceView cDNA sequences (see all 758): AW613698 BQ221471 BM560380 BF108826 BQ709516 AW015861 AI825123 CB115033 AI204368 BC001173 BQ669015 CA434118 BP368238 BU175745 CD673946 BU856686 AI699769 CR603939 AI336324 BQ643260 AU124102 AW473838 BM904776 BU956074
GeneLoc Exon Structure
18 Alternative Splicing Database (ASD) splice patterns (SP) for EIF3B (see first 5) About this scheme
| ExUns: | 1 | ^ | 2 | ^ | 3a | · | 3b | · | 3c | ^ | 4a | · | 4b | ^ | 5a | · | 5b | ^ | 6a | · | 6b | ^ | 7a | · | 7b | ^ | 8a | · | 8b | ^ | 9a | · | 9b | · | 9c | ^ | 10 | ^ | 11a | · | 11b | ^ | 12a | · | 12b | ^ | 13 | ^ | 14 | ^ | 15a | · |
|---|
|
| SP1: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | - | | | | | | | | | | - | | | | - | | - | | | | | | |
| SP2: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | - | | | | | | | | | | - | | | | - | | - | | | | | | |
| SP3: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | - | | | | | | | | | | - | | | | - | | - | | | | | | |
| SP4: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | - | | | | | | | | | | - | | | | - | | - | | | | | | |
| SP5: | | | - | | - | | - | | - | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP6: | | | | | | | | | - | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP7: | | | | | | | | | | | | | | | | | | | | | | | | | - | | - | | - | | - | | - | | - | | - | | - | | - | | - | | - | | - | | - | | - | | |
| SP8: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP9: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP10: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | - | | | | - | | - | | | | | | |
| SP11: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP12: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP13: | | | | | - | | - | | - | | - | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP14: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP15: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | - | | | | | | | | | | | | |
| SP16: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP17: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP18: | | | | | | | | | | | | | | | - | | - | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| ExUns: | 15b | · | 15c | ^ | 16 | ^ | 17a | · | 17b | ^ | 18 | ^ | 19a | · | 19b | · | 19c | ^ | 20a | · | 20b | ^ | 21 | ^ | 22a | · | 22b | ^ | 23a | · | 23b | ^ | 24a | · | 24b | · | 24c |
|---|
|
| SP1: | | | - | | | | - | | | | | | - | | | | | | | | | | | | | | - | | - | | | | - | | | | | | |
| SP2: | | | - | | | | - | | | | | | - | | | | | | | | | | | | | | - | | | | | | | | | | | | |
| SP3: | | | - | | | | - | | | | | | - | | | | | | | | | | | | | | - | | - | | | | | | | | | | |
| SP4: | | | - | | | | - | | | | | | - | | | | | | | | | | | | | | - | | - | | | | | | | | | | |
| SP5: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP6: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP7: | | | - | | | | - | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP8: | | | | | | | | | | | | | - | | | | | | | | | | | | | | - | | | | | | | | | | | | |
| SP9: | | | | | | | | | | | | | | | | | | | | | | | | | | | - | | - | | | | | | | | | | |
| SP10: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP11: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP12: | | | | | | | | | | | | | | | | | | | | | | | | | | | - | | - | | - | | | | | | | | |
| SP13: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP14: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP15: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP16: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP17: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP18: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
ECgene alternative splicing isoforms for EIF3B
|
Expression
for EIF3B gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| EIF3B expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GAAATAAAAG
About this image
See EIF3B Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for EIF3B
SOURCE GeneReport for Unigene cluster: Hs.371001
SABiosciences Custom PCR Arrays for EIF3B
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for EIF3B
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat EIF3B | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat EIF3B | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat EIF3B | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for EIF3B |
Orthologs
for EIF3B gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of eukaryotes.
Orthologs for EIF3B gene from 9/36 species (see all 36) About this table
ENSEMBL Gene Tree for EIF3B (if available)
TreeFam Gene Tree for EIF3B (if available) |
Paralogs
for EIF3B gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| -- |
Genomic Variants
for EIF3B gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 7 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for EIF3B (2393721 - 2420380 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 9 variations for EIF3B
2 CNVs: 69768 99846
7 Indels: 94341 12902 81845 69769 12901 28608 12900 | SABiosciences Cancer Mutation PCR Assays |
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Disorders
/ Diseases
for EIF3B gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
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EIF3B for disorders About GeneDecksing
OMIM gene information: 603917
OMIM disorders: --
4  diseases for EIF3B: About MalaCardsmouth disease tetralogy of fallot melanoma malaria
Export disorders for EIF3B gene to outside databases
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Publications
for EIF3B gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
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PubMed articles for EIF3B gene, integrated from 9 sources (see all 73):
(articles sorted by number of sources associating them with EIF3B) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- The human homologue of the yeast Prt1 protein is an integral part of the eukaryotic initiation factor 3 complex and interacts with p170. (PubMed id 8995410)1, 2, 3, 9 Methot N.... Sonenberg N. (1997)
- Molecular interaction between human tumor marker protein p150, the largest subunit of eIF3, and intermediate filament protein K7. (PubMed id 11169732)1, 2, 9 Lin L.... Burger M.M. (2001)
- Biochemical characterization of mammalian translation initiation factor 3 (eIF3). Molecular cloning reveals that p110 subunit is the mammalian homologue of Saccharomyces cerevisiae protein Prt1. (PubMed id 9388245)1, 2, 9 Chaudhuri J.... Maitra U. (1997)
- Mass spectrometry reveals modularity and a complete subunit interaction map of the eukaryotic translation factor eIF3. (PubMed id 18599441)1, 2 Zhou M....Robinson C.V. (2008)
- Reconstitution reveals the functional core of mammalian eIF3. (PubMed id 17581632)1, 2 Masutani M.... Imataka H. (2007)
- Structural characterization of the human eukaryotic initiation factor 3 protein complex by mass spectrometry. (PubMed id 17322308)1, 2 Damoc E....Leary J.A. (2007)
- Structure of eIF3b RNA recognition motif and its interaction with eIF3j: structural insights into the recruitment of eIF3b to the 40 S ribosomal subunit. (PubMed id 17190833)1, 2 ElAntak L.... Lukavsky P.J. (2007)
- Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)1, 2 Olsen J.V....Mann M. (2006)
- mTOR and S6K1 mediate assembly of the translation preinitiation complex through dynamic protein interchange and ordered phosphorylation events. (PubMed id 16286006)1, 2 Holz M.K.... Blenis J. (2005)
- The j-subunit of human translation initiation factor eIF3 is required for the stable binding of eIF3 and its subcomplexes to 40 S ribosomal subunits in vitro. (PubMed id 14688252)1, 2 Fraser C.S....Hershey J.W. (2004)
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External Searches for EIF3B gene
(in PubMed,
OMIM, and NCBI Bookshelf)
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Genome Databases showing EIF3B gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
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Other Databases showing EIF3B gene
(According to HUGE)
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| -- |
Specialized Databases showing EIF3B gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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| Name | Description |
| PharmGKB entry for EIF3B | Pharmacogenomics, SNPs, Pathways |
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About This Section
| Patent Information for EIF3B gene:
Search GeneIP for patents involving EIF3B
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
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Products
for EIF3B gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
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