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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

EIF3B Gene

protein-coding   GIFtS: 59
GCID: GC07P002362

Eukaryotic Translation Initiation Factor 3, Subunit B

(Previous names: eukaryotic translation initiation factor 3, subunit 9 eta,...)
(Previous symbol: EIF3S9)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Eukaryotic Translation Initiation Factor 3, Subunit B1 2     hPrt12 3
EIF3S91 2 3 5     PRT12 5
Eukaryotic Translation Initiation Factor 3, Subunit 9 Eta, 116kDa1 2     EIF3-ETA2
Eukaryotic Translation Initiation Factor 3 Subunit 92 3     EIF3-P1102
Prt1 Homolog2 3     EIF3-P1162
eIF-3-eta2 3     Eukaryotic Translation Initiation Factor 3 Subunit B2
EIF3 P1102 3     Eukaryotic Translation Initiation Factor 3, Subunit 9 (Eta, 116kD)2
EIF3 P1162 3     eIF3b3

External Ids:    HGNC: 32801   Entrez Gene: 86622   Ensembl: ENSG000001062637   OMIM: 6039175   UniProtKB: P558843   

Export aliases for EIF3B gene to outside databases


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for EIF3B Gene: 
EIF3B (eukaryotic translation initiation factor 3, subunit B) is a protein-coding gene. Diseases associated with EIF3B include mouth disease, and tetralogy of fallot, and among its related super-pathways are Eukaryotic Translation Initiation and Formation of the ternary complex, and subsequently, the 43S complex. GO annotations related to this gene include protein complex scaffold and nucleotide binding.

UniProtKB/Swiss-Prot: EIF3B_HUMAN, P55884
Function: Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for
several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and
facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S preinitiation
complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG
recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal
complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation

Gene Wiki entry for EIF3B Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000007.13  NC_018918.2  NT_007819.17  NT_079592.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the EIF3B gene promoter:
         Max1   Pax-5   NF-E2 p45   Egr-4   AREB6   Pax-4a   NF-E2   ATF   ATF6   c-Myc   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 11): EIF3B promoter sequence
   Search SABiosciences Chromatin IP Primers for EIF3B

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat EIF3B


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 7p22.3   Ensembl cytogenetic band:  7p22.3   HGNC cytogenetic band: 7p22

EIF3B Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
EIF3B gene location

GeneLoc information about chromosome 7         GeneLoc Exon Structure

GeneLoc location for GC07P002362:  view genomic region     (about GC identifiers)

Start:
2,393,721 bp from pter      End:
2,420,380 bp from pter
Size:
26,660 bases      Orientation:
plus strand

1 alternative location:
Chr7+,CRA_TCAG 2,442,541-2,468,274     

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: EIF3B_HUMAN, P55884 (See protein sequence)
Recommended Name: Eukaryotic translation initiation factor 3 subunit B  
Size: 814 amino acids; 92482 Da
Subunit: Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is composed of 13
subunits: EIF3A, EIF3B, EIF3C, EIF3D, EIF3E, EIF3F, EIF3G, EIF3H, EIF3I, EIF3J, EIF3K, EIF3L and EIF3M. The eIF-3
complex appears to include 3 stable modules: module A is composed of EIF3A, EIF3B, EIF3G and EIF3I; module B is
composed of EIF3F, EIF3H, and EIF3M; and module C is composed of EIF3C, EIF3D, EIF3E, EIF3K and EIF3L. EIF3C of
module C binds EIF3B of module A and EIF3H of module B, thereby linking the three modules. EIF3J is a labile
subunit that binds to the eIF-3 complex via EIF3B. The eIF-3 complex interacts with RPS6KB1 under conditions of
nutrient depletion. Mitogenic stimulation leads to binding and activation of a complex composed of MTOR and
RPTOR, leading to phosphorylation and release of RPS6KB1 and binding of EIF4B to eIF-3. Also interacts with UPF2
Subcellular location: Cytoplasm (By similarity)
Mass spectrometry: Mass=93093.7; Method=Unknown; Range=1-814; Source=PubMed:17322308;
Mass spectrometry: Mass=92561; Mass_error=43.5; Method=MALDI; Range=1-814; Source=PubMed:18599441;
2 PDB 3D structures from and Proteopedia for EIF3B:
2KRB (3D)        2NLW (3D)    
Secondary accessions: A4D208 Q2NL77 Q9UMF9
Alternative splicing: 2 isoforms:  P55884-1   P55884-2   

Explore the universe of human proteins at neXtProt for EIF3B: NX_P55884

Explore proteomics data for EIF3B at MOPED 

Post-translational modifications:

  • UniProtKB: Phosphorylated. Phosphorylation is enhanced upon serum stimulation
  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_P55884

  • EIF3B Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    EIF3B Protein Expression
    REFSEQ proteins (2 alternative transcripts): 
    NP_001032360.1  NP_003742.2  

    ENSEMBL proteins: 
     ENSP00000408062   ENSP00000354125   ENSP00000407785   ENSP00000380206  
    Reactome Protein details: P55884
    Human Recombinant Protein Products for EIF3B: 
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    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for EIF3B 

    Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005829cytosol TAS--
    GO:0005852eukaryotic translation initiation factor 3 complex IDA17322308
    GO:0016282eukaryotic 43S preinitiation complex IEA--
    GO:0033290eukaryotic 48S preinitiation complex IEA--

    EIF3B for ontologies           About GeneDecksing



    EIF3B Antibody Products: 
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    Cloud-Clone Corp. CLIAs for EIF3B


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    RBM: RNA binding motif (RRM) containing

    5 InterPro protein domains:
     IPR013979 TIF_beta_prop-like
     IPR000504 RRM_dom
     IPR012677 Nucleotide-bd_a/b_plait
     IPR015943 WD40/YVTN_repeat-like_dom
     IPR011400 EIF3B

    Graphical View of Domain Structure for InterPro Entry P55884

    ProtoNet protein and cluster: P55884

    2 Blocks protein domains:
    IPB000504 RNA-binding region RNP-1 (RNA recognition motif)
    IPB013979 Eukaryotic translation initiation factor 2A


    UniProtKB/Swiss-Prot: EIF3B_HUMAN, P55884
    Domain: The RRM domain mediates interaction with EIF3J
    Similarity: Belongs to the eIF-3 subunit B family
    Similarity: Contains 1 RRM (RNA recognition motif) domain
    Similarity: Contains 5 WD repeats


    EIF3B for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: EIF3B_HUMAN, P55884
    Function: Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for
    several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and
    facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S preinitiation
    complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG
    recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal
    complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation

         Gene Ontology (GO): 5/7 molecular function terms (GO ID links to tree view) (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000166nucleotide binding IEA--
    GO:0003676nucleic acid binding ----
    GO:0003723RNA binding ----
    GO:0003743contributes to translation initiation factor activity IDA17581632
    GO:0005515protein binding IPI11169732
         
    EIF3B for ontologies           About GeneDecksing


    Phenotypes:
         5 GenomeRNAi human phenotypes for EIF3B:
     Decreased G3BP1 protein expres  Decreased viability of wild-ty  Increased cell death in HCT116  Nuclear 60S biogenesis defects 
     Nucleolar pre-40S maturation d 

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for EIF3B 
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for EIF3B 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for EIF3B 

    miRNA
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    hsa-miR-3140-3p hsa-miR-124 hsa-miR-198 hsa-miR-525-5p hsa-miR-506 hsa-miR-520a-5p
    SwitchGear 3'UTR luciferase reporter plasmidEIF3B 3' UTR sequence
    Inhib. RNA
    Products:
        
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    Gene Editing
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    Clone
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    GenScript: all cDNA clones in your preferred vector (see all 2): EIF3B (NM_003751)
    Browse Sino Biological Human cDNA Clones
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for EIF3B


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for EIF3B About   (see all 6)                                                                                              See pathways by source

    SuperPathContained pathways About
    1Viral mRNA Translation
    GTP hydrolysis and joining of the 60S ribosomal subunit0.94
    L13a-mediated translational silencing of Ceruloplasmin expression0.93
    Eukaryotic Translation Initiation0.94
    Formation of a pool of free 40S subunits0.90
    Cap-dependent Translation Initiation0.94
    Translation0.78
    3' -UTR-mediated translational regulation0.93
    2Translation initiation complex formation
    Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S0.95
    Formation of the ternary complex, and subsequently, the 43S complex0.87
    Ribosomal scanning and start codon recognition0.95
    Translation initiation complex formation0.87
    3Generic Transcription Pathway
    Gene Expression0.47
    4Asparagine N-linked glycosylation
    Metabolism of proteins0.35
    5Translation Factors
    Translation Factors

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 BioSystems Pathway for EIF3B
        Translation Factors

    5/13        Reactome Pathways for EIF3B (see all 13)
        Formation of the ternary complex, and subsequently, the 43S complex
    Translation
    GTP hydrolysis and joining of the 60S ribosomal subunit
    Eukaryotic Translation Initiation
    Ribosomal scanning and start codon recognition


    1         Kegg Pathway  (Kegg details for EIF3B):
        RNA transport


    EIF3B for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for EIF3B

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/762 Interacting proteins for EIF3B (P558841, 2, 3 ENSP000003541254) via UniProtKB, MINT, STRING, and/or I2D (see all 762)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    HIST1H4AP628053I2D: score=1 
    HIST1H4BP628053I2D: score=1 
    HIST1H4CP628053I2D: score=1 
    HIST1H4DP628053I2D: score=1 
    HIST1H4EP628053I2D: score=1 
    About this table

    Gene Ontology (GO): 5/6 biological process terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001731formation of translation preinitiation complex IEA--
    GO:0006412translation TAS--
    GO:0006413translational initiation TAS--
    GO:0006446regulation of translational initiation IDA8995410
    GO:0010467gene expression TAS--

    EIF3B for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for EIF3B

    Search CenterWatch for drugs/clinical trials and news about EIF3B

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for EIF3B gene (2 alternative transcripts): 
    NM_001037283.1  NM_003751.3  

    Unigene Cluster for EIF3B:

    Eukaryotic translation initiation factor 3, subunit B
    Hs.371001  [show with all ESTs]
    Unigene Representative Sequence: AB209381
    12 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000431643 ENST00000360876(uc003slx.3 uc003sly.3 uc003slz.1)
    ENST00000413917 ENST00000397011(uc003sma.3) ENST00000463229 ENST00000463026
    ENST00000468250 ENST00000466199 ENST00000475415 ENST00000468611(uc003smb.3)
    ENST00000465670 ENST00000494658
    miRNA
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    SwitchGear 3'UTR luciferase reporter plasmidEIF3B 3' UTR sequence
    Inhib. RNA
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat EIF3B
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    Additional mRNA sequence: 

    AB209381.1 AK127885.1 AK300967.1 AK302058.1 BC001173.1 BC009986.1 BC110865.1 U62583.1 
    U78525.1 

    24/35 DOTS entries (see all 35):

    DT.100834695  DT.97798019  DT.100759692  DT.95173385  DT.100834690  DT.454061  DT.100730058  DT.429116 
    DT.92462641  DT.97786597  DT.203336  DT.70104982  DT.102836765  DT.100039603  DT.95305235  DT.95148198 
    DT.97864515  DT.121124337  DT.95313948  DT.100834693  DT.121124353  DT.100033517  DT.100834684  DT.100834692 

    758 AceView cDNA sequences (see top 24):

    CA313146 AI990399 BQ015102 BM790290 BQ220582 BU539252 BU860027 CF455722 
    BG260460 CA414423 BU184482 BU539785 BG679127 BM904776 CF131575 BQ184896 
    AW402799 BM455055 BM560380 AI160080 CR603885 BQ221471 BG481207 BU631424 
    BQ278601 AI336324 BM715292 CB123612 AI677741 AU124308 BU195154 AI917315 
    AW674009 BU191062 BG232076 BQ055044 CB162484 BM817777 BU157891 BQ951011 
    CB136374 AA362023 BU145769 AI917167 BU538311 BG741900 BQ008308 BU855360 
    BQ233401 CD673945 BU956501 BQ055760 CB163685 BP368238 BU738863 BF770052 
    AK093807 BF813415 BU857233 BI910269 BQ277728 AI204368 BU729506 BM561549 
    BQ709517 BM919002 AI184631 BU520863 BG392270 BQ059640 BU179964 CB158647 
    BQ068469 AA308795 CA434118 BM851047 CB115033 BE905387 BQ643260 CA487473 
    CB109431 AU124102 BQ689310 BQ947933 AW613698 BM764889 AU141079 BM915884 
    CK820332 BU857372 AI061207 AA317389 CF129633 BC001173 CA414416 AI369599 
    BM803878 BI768671 BU196873 BU956074 BE890169 BU944742 AI590828 AW006622 
    BQ217164 BQ218083 BU175745 AI674885 BM916331 BM480181 BX113390 BU856627 
    CA307034 AU132838 BQ962554 AI699769 BE900418 T30307 AI825123 BQ709516 
    AU117743 BF108826 BU184533 BM550181 BQ055964 BG231877 BU194506 AA233940 
    BQ428348 BU742454 BQ049788 NM_003751 AU134271 BE018042 BQ669015 BQ430432 
    AW250679 BM461502 BU849141 BU856686 BQ883620 CK820331 CA407698 BQ674817 
    AU129038 AW189503 AI146462 BG116146 CD360052 CD673946 NM_182712 BM852220 
    BG576318 CR603939 AI651395 BE263883 AW473838 AW015861 AA488488 BU619877 
    BU170360 AU123908 BM459410 BM821172 BF570200 BM561944 BM740844 BU539745 
    BE392800 BM017272 AI991032 BQ893913 BM850982 AU136573 BG824305 BU845595 
    BU540903 BI859192 BI160391 BQ441191 BE746701 BG166818 BQ072014 AU142395 
    BG477028 AW137834 AA126089 BQ922638 CF127835 CB105489 AA582186 BQ689565 
    BG682007 BG821716 BF723621 BM556863 BG830394 CB996122 BX350414 BU856742 
    BM771754 U78525 BX404747 BM553252 BG716407 BQ423745 BG230627 AA382480 
    BG236181 AW732308 CA453776 BM740894 BQ050287 CF140397 BQ959915 BG115291 
    BQ230894 BE311638 BF311195 U62583 BI259907 BE250139 BX643321 BE292783 
    AL555877 AI093504 BM556498 AI470034 AA233938 AA617983 BG036475 BG332502 
    F25750 BG397565 BE382827 BM673479 BM750760 BG107631 BM982213 CB106090 
    BQ953563 AA404624 BU169197 CD654153 AA088189 AA580653 AA463907 AI143144 
    BI046667 BX646879 BE281495 BX378706 T34658 AK126670 BE514703 BU181802 
    AA314123 BF528565 AA552240 BE302737 BG396813 BM473424 AU122993 BG477085 
    AI199495 BE301216 AA088362 BU944669 BM019847 BE393536 BX341080 AL121449 
    BU501863 BG339963 BQ431865 BM826617 BQ920488 BE559849 BG767688 AW008156 
    BQ045103 AI094686 BE894884 BG341912 BX421103 BE514079 BU193792 BE743505 
    BI258838 AI683669 AI084083 BE385024 AA618077 BE394644 AA939273 BQ945767 
    BQ900396 R52935 CA447846 BG741163 BE906886 BE393907 AL555876 AI253645 
    BE261485 BE906945 BP355584 BF198092 BE881698 CD370042 BE271068 F35747 
    BQ670939 BE873460 BQ651386 BG167893 CO406196 BF683408 AI083900 BQ641989 
    BQ689745 BG677679 BG281034 AW967067 CA415628 BF311078 AA676471 BQ919213 
    CD721972 BE786131 BE870034 BF025775 BE902063 BU149363 AI636782 BU931515 
    BG167192 CB991375 BG248478 CB160283 BM050761 BC009986 CD617455 BU180619 
    BF591005 BI597188 AW516174 BG328532 BP378635 BG256951 BM668006 BE560504 
    CB144447 CA427912 BG831507 BG168072 CB152987 BG290512 BF982560 AA505648 
    BU850015 BM771714 BE892954 BE901673 AU134056 BQ423021 BE278590 AV655629 
    AI167619 BG767676 BM701972 BQ001994 BE797023 BI159903 CF140230 AA570378 
    AA649216 BI489741 BU729638 BI088958 AA813429 CB148557 BX345105 BQ959241 
    BG035381 BM043107 BM703542 BE908155 BE546791 BG494774 BG468160 BF347468 
    BU541006 BM997834 BM715334 AW005621 BU146130 BG113031 BI116228 AA488357 
    CF126042 AA158751 BE904821 BM727927 BI093742 BQ073423 BG030909 BG028527 
    AA970871 CB133155 BG170983 BQ186688 AW117927 AA669005 AA908740 BQ223243 
    BG248381 AW408372 BM696975 BG034607 BF983419 AU138091 BU183714 BM810277 
    BQ917499 BQ722589 AA742211 BU858271 AL581202 BG034012 BM020442 BF313258 
    BQ017748 AA778172 AA301529 BI227087 AA297611 BU172069 AJ708525 AW151381 
    BG774395 BG682350 BQ894874 BG035087 BG327541 CA306182 BU600913 AA116114 
    BQ227351 AA235397 AA385526 AA552123 BU686943 BQ070291 BU902631 AI623731 
    AW409951 BG104253 BM845451 BQ055933 BF038693 BG334259 AW195118 BM558917 
    AA237074 BF569224 CD358807 BG115662 AW129967 BG420074 BG739777 BQ953397 
    CF145841 AA665859 AU122095 BP344622 AW129658 AA809842 BG177850 AA079742 
    AI888128 AA486040 AA541400 BG110694 BE902722 BG109006 BM478034 BV199886 
    BV205085 AA632946 BF526163 BE883786 AA404742 AA563620 BQ340026 BQ270523 
    AW948686 BU501538 R71705 CA433950 AL713020 BE719494 BG112358 BG120462 
    H01480 BU657251 BU844806 BG422811 AI699772 AA085266 AA053087 AI420704 
    AA236873 AA133315 CO245996 BG252113 BQ300572 AI983095 AI571152 BE867203 
    BE397388 BF853695 AA628138 BM851419 BI764613 BF316431 BM751002 AL559626 
    BG482038 BG338604 AI735064 AA133730 AI963293 AW872879 AA628539 AA362769 
    BG028015 CF142173 AA158750 BF125247 AA219668 BG769475 AI871254 BE265461 
    AA410782 BM013875 BI915674 AA659171 BQ720621 BI046766 BQ070292 AL706581 
    BF663062 AA995931 BE276703 AW380677 AU155335 BF314448 BI046850 CB117303 
    N57726 BF791485 BE271280 N23233 CA772613 BQ224115 BF804972 AA133729 
    AA115255 BI046666 BG253812 AA523216 BE513058 CO249172 H81550 BI117218 
    BE305079 BM925432 BM714163 BE910193 BG622080 C02897 AL706593 AI683222 
    AU157465 CB997422 BE293405 AA078364 AA069854 BF316486 BG178238 AA224817 
    BF435712 BE905739 AA679866 BG474983 BG325094 AA078608 AA514273 AU155169 
    AI907183 BE261046 AA169790 AI147837 BE733424 BF971955 BE206861 BF849334 
    AW247372 AA209528 AW662461 AA321006 BE305198 AW733097 BE410262 R53715 
    AA297061 T86402 AA994427 BM707369 AW024865 AW674791 BF345123 BI046146 
    BI045494 AI951255 BQ899255 AA133316 BM449485 BG252112 BU190465 AU154289 
    BG829950 BI046767 AL530027 T86304 BI045847 AA532367 BQ216625 AI611443 
    BX376572 CF141081 AI766754 BE719551 AU144493 BE536997 BQ072312 AL516018 
    AA720530 BP377064 AW382605 BI046127 BQ549973 BE153245 AA297919 CB132396 
    BI459262 BF921134 BE276396 BU857416 BI046425 CF141097 AA256948 BX440322 
    AI863874 BF799441 AW960164 BU176245 BF815624 AW579447 BF962361 AA125967 
    BX089491 BG116314 BF770044 AA078276 W60459 BE561750 AW138226 BG831242 
    AA223205 AA426530 AW579567 BF738956 AU151224 T84174 BE881825 BI085798 
    BG950427 BE814777 H30172 AA228468 AA115254 AA079743 AA729492 BQ641866 
    AA625179 AU159731 BF814896 BG253176 AA157839 AA418901 H67231 AW207523 
    BQ446012 BF530111 BF798259 AW663337 AW391639 T60660 BF674919 H01579 
    BE002602 BF375300 CB998177 BQ320200 AA101685 BM797723 D59393 BM556261 
    BG488818 BQ684826 BE706544 BM974895 AA053598 BE546441 BG014886 BE153255 
    BF512712 AW368037 BG423105 BU527300 BE908890 H28286 T19283 BX352322 
    AA602235 BF901849 BE715197 CB997652 BE706672 BE719496 CB996850 BQ320179 
    BE706694 AW796939 BF331267 AW377443 AA116115 BE153234 AW884172 BG911296 
    BQ307622 BE715160 CK002744 BQ376118 BE893954 BF313480 

    GeneLoc Exon Structure

    5/18 Alternative Splicing Database (ASD) splice patterns (SP) for EIF3B (see all 18)    About this scheme

    ExUns: 1 ^ 2 ^ 3a · 3b · 3c ^ 4a · 4b ^ 5a · 5b ^ 6a · 6b ^ 7a · 7b ^ 8a · 8b ^ 9a · 9b · 9c ^ 10 ^ 11a · 11b ^ 12a · 12b ^ 13 ^ 14 ^ 15a ·
    SP1:                                                                                            -                             -           -     -               
    SP2:                                                                                            -                             -           -     -               
    SP3:                                                                                            -                             -           -     -               
    SP4:                                                                                            -                             -           -     -               
    SP5:        -     -     -     -                                                                                                                                 

    ExUns: 15b · 15c ^ 16 ^ 17a · 17b ^ 18 ^ 19a · 19b · 19c ^ 20a · 20b ^ 21 ^ 22a · 22b ^ 23a · 23b ^ 24a · 24b · 24c
    SP1:        -           -                 -                                         -     -           -               
    SP2:        -           -                 -                                         -                                 
    SP3:        -           -                 -                                         -     -                           
    SP4:        -           -                 -                                         -     -                           
    SP5:                                                                                                                  


    ECgene alternative splicing isoforms for EIF3B

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    EIF3B expression in normal human tissues (normalized intensities)      EIF3B embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GAAATAAAAG
    EIF3B Expression
    About this image


    EIF3B expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/1 selected tissues (see all 1) fully expand
     
     Heart (Cardiovascular System)
             Outflow Tract

    See EIF3B Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for EIF3B

    SOURCE GeneReport for Unigene cluster: Hs.371001
        SABiosciences Custom PCR Arrays for EIF3B
    Primer
    Products:
    OriGene qPCR primer pairs and template standards for EIF3B
    OriGene qSTAR qPCR primer pairs in human, mouse for EIF3B
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat EIF3B
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat EIF3B
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat EIF3B
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for EIF3B

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of eukaryotes.

    Orthologs for EIF3B gene from 10/25 species (see all 25)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Eif3b1 , 5 eukaryotic translation initiation factor 3, subunit more1, 5 85.68(n)1
    92.51(a)1
      5 (78.97 cM)5
    279791  NM_133916.21  NP_598677.11 
     1404193055 
    chicken
    (Gallus gallus)
    Aves EIF3B1 eukaryotic translation initiation factor 3, subunit more 79.62(n)
    91.02(a)
      769783  XM_003642142.1  XP_003642190.1 
    lizard
    (Anolis carolinensis)
    Reptilia EIF3B6
    --
    Uncharacterized protein
    72(a)
    56(a)
    many → 1
    many → 1
    GL343340.1(41712-52758)
    GL343307.1(1301747-1303336)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.260732 Xenopus laevis transcribed sequence with moderate similarity more 77.37(n)    48055327 
    zebrafish
    (Danio rerio)
    Actinopterygii wufc17c012 wufc17c01 82.82(n)   324028  CA787533.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta eIF3-S91 CG4878-PA 58.47(n)
    53.76(a)
      36981  NM_137384.3  NP_611228.1 
    worm
    (Caenorhabditis elegans)
    Secernentea eif-3.B1 Protein EIF-3.B 46.13(n)
    36.6(a)
      175138  NM_001027298.3  NP_001022469.1 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes PRT1(YOR361C)4
    PRT11
    eIF3b subunit of the core complex of translation initiation more4
    Prt1p1
    47.92(n)1
    34.28(a)1
      15(1017652-1015361)4
    8545431, 4  NP_015006.31  NP_015006.14 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons TIF3B11 translation initiation factor 3 subunit B 53.14(n)
    43.23(a)
      832826  NM_001036877.2  NP_001031954.1 
    rice
    (Oryza sativa)
    Liliopsida Os.48992 Oryza sativa (japonica cultivar-group) cDNA clone0 more 70.36(n)    AK110143.1 


    ENSEMBL Gene Tree for EIF3B (if available)
    TreeFam Gene Tree for EIF3B (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for EIF3B gene
    1 SIMAP similar gene for EIF3B using alignment to 7 protein entries:     EIF3B_HUMAN (see all proteins):
    EIF3S9

    EIF3B for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/980 SNPs in EIF3B are shown (see all 980)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 7 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs77959371,2
    C--2392502(+) cttatC/Tgtaca 2 -- us2k10--------
    rs1866445271,2
    --2392544(+) ACCTGC/TCCAAA 2 -- us2k10--------
    rs1911089171,2
    C--2392571(+) CATGAC/TGAGGA 2 -- us2k10--------
    rs1405732621,2
    --2392678(+) AGTCCC/TGGCAC 2 -- us2k10--------
    rs749343721,2
    F--2392748(+) ACACAG/ATGAGA 2 -- us2k11Minor allele frequency- A:0.03NA 120
    rs1457357701,2
    --2392785(+) TGGGCA/GCGGTG 2 -- us2k10--------
    rs624441621,2
    C,F--2392860(+) GCATAT/CTAAAA 2 -- us2k12Minor allele frequency- C:0.08NA 122
    rs1825669971,2
    --2392876(+) AGGCCC/GTGCGC 2 -- us2k10--------
    rs1418556821,2
    --2392881(+) CTGCGC/GGGTGG 2 -- us2k10--------
    rs77929341,2
    C,F--2393016(+) accctG/Atctct 2 -- us2k112Minor allele frequency- A:0.24NA WA CSA EA 374

    HapMap Linkage Disequilibrium report for EIF3B (2393721 - 2420380 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 10/14 variations for EIF3B (see all 14):    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2733848CNV Deletion23290073
    esv2663485CNV Deletion23128226
    dgv1118e201CNV Deletion23290073
    esv2424013CNV Deletion19546169
    esv2733846CNV Deletion23290073
    esv2733849CNV Deletion23290073
    esv2733845CNV Deletion23290073
    esv2140457CNV Deletion18987734
    esv1406872CNV Deletion17803354
    esv2733851CNV Deletion23290073

    SABiosciences Cancer Mutation PCR Assays
    Search QIAGEN SeqTarget long-range PCR primers for resequencing EIF3B
    DNA2.0 Custom Variant and Variant Library Synthesis for EIF3B

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 603917    OMIM disorders: --

    3 diseases for EIF3B:    About MalaCards
    mouth disease    tetralogy of fallot    melanoma


    EIF3B for disorders           About GeneDecksing


    Export disorders for EIF3B gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for EIF3B gene, integrated from 9 sources (see all 84):
    (articles sorted by number of sources associating them with EIF3B)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The human homologue of the yeast Prt1 protein is an integral part of the eukaryotic initiation factor 3 complex and interacts with p170. (PubMed id 8995410)1, 2, 3, 9 Methot N.... Sonenberg N. (1997)
    2. Molecular interaction between human tumor marker protein p150, the largest subunit of eIF3, and intermediate filament protein K7. (PubMed id 11169732)1, 2, 9 Lin L.... Burger M.M. (2001)
    3. Biochemical characterization of mammalian translation initiation factor 3 (eIF3). Molecular cloning reveals that p110 subunit is the mammalian homologue of Saccharomyces cerevisiae protein Prt1. (PubMed id 9388245)1, 2, 9 Chaudhuri J.... Maitra U. (1997)
    4. Mass spectrometry reveals modularity and a complete subunit interaction map of the eukaryotic translation factor eIF3. (PubMed id 18599441)1, 2 Zhou M....Robinson C.V. (2008)
    5. Reconstitution reveals the functional core of mammalian eIF3. (PubMed id 17581632)1, 2 Masutani M.... Imataka H. (2007)
    6. Structural characterization of the human eukaryotic initiation factor 3 protein complex by mass spectrometry. (PubMed id 17322308)1, 2 Damoc E....Leary J.A. (2007)
    7. Structure of eIF3b RNA recognition motif and its interaction with eIF3j: structural insights into the recruitment of eIF3b to the 40 S ribosomal subunit. (PubMed id 17190833)1, 2 ElAntak L.... Lukavsky P.J. (2007)
    8. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)1, 2 Olsen J.V....Mann M. (2006)
    9. mTOR and S6K1 mediate assembly of the translation preinitiation complex through dynamic protein interchange and ordered phosphorylation events. (PubMed id 16286006)1, 2 Holz M.K.... Blenis J. (2005)
    10. The j-subunit of human translation initiation factor eIF3 is required for the stable binding of eIF3 and its subcomplexes to 40 S ribosomal subunits in vitro. (PubMed id 14688252)1, 2 Fraser C.S....Hershey J.W. (2004)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 8662 HGNC: 3280 AceView: EIF3S9 Ensembl:ENSG00000106263 euGenes: HUgn8662
    ECgene: EIF3B Kegg: 8662 H-InvDB: EIF3B

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for EIF3B Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for EIF3B gene:
    Search GeneIP for patents involving EIF3B

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

     
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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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    Category
    (GIFtS: 73)
    transforming growth factor, beta 1
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


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