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EIF3B Gene

protein-coding   GIFtS: 59
GCID: GC07P002362

Eukaryotic Translation Initiation Factor 3, Subunit B

(Previous names: eukaryotic translation initiation factor 3, subunit 9 eta,...)
(Previous symbol: EIF3S9)
  Search for EIF3B
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Eukaryotic Translation Initiation Factor 3, Subunit B1 2     hPrt12 3
EIF3S91 2 3 5     PRT12 5
Eukaryotic Translation Initiation Factor 3, Subunit 9 Eta, 116kDa1 2     EIF3-ETA2
Eukaryotic Translation Initiation Factor 3 Subunit 92 3     EIF3-P1102
Prt1 Homolog2 3     EIF3-P1162
eIF-3-eta2 3     Eukaryotic Translation Initiation Factor 3 Subunit B2
EIF3 P1102 3     Eukaryotic Translation Initiation Factor 3, Subunit 9 (Eta, 116kD)2
EIF3 P1162 3     eIF3b3

External Ids:    HGNC: 32801   Entrez Gene: 86622   Ensembl: ENSG000001062637   OMIM: 6039175   UniProtKB: P558843   

Export aliases for EIF3B gene to outside databases


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for EIF3B Gene:
EIF3B (eukaryotic translation initiation factor 3, subunit B) is a protein-coding gene. GO annotations related to this gene include protein complex scaffold and nucleotide binding.

UniProtKB/Swiss-Prot: EIF3B_HUMAN, P55884
Function: Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for
several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and
facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S preinitiation
complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG
recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal
complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation

Gene Wiki entry for EIF3B Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000007.13  NC_018918.2  NT_007819.18  
Regulatory elements:
   Regulatory transcription factor binding sites in the EIF3B gene promoter:
         Max1   Pax-5   NF-E2 p45   Egr-4   AREB6   Pax-4a   NF-E2   ATF   ATF6   c-Myc   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 11): EIF3B promoter sequence
   Search Chromatin IP Primers for EIF3B

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat EIF3B


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 7p22.3   Ensembl cytogenetic band:  7p22.3   HGNC cytogenetic band: 7p22

EIF3B Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
EIF3B gene location

GeneLoc information about chromosome 7         GeneLoc Exon Structure

GeneLoc location for GC07P002362:  view genomic region     (about GC identifiers)

Start:
2,393,721 bp from pter      End:
2,420,380 bp from pter
Size:
26,660 bases      Orientation:
plus strand

1 alternative location:
Chr7+,CRA_TCAG 2,442,541-2,468,274     

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: EIF3B_HUMAN, P55884 (See protein sequence)
Recommended Name: Eukaryotic translation initiation factor 3 subunit B  
Size: 814 amino acids; 92482 Da
Subunit: Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is composed of 13
subunits: EIF3A, EIF3B, EIF3C, EIF3D, EIF3E, EIF3F, EIF3G, EIF3H, EIF3I, EIF3J, EIF3K, EIF3L and EIF3M. The eIF-3
complex appears to include 3 stable modules: module A is composed of EIF3A, EIF3B, EIF3G and EIF3I; module B is
composed of EIF3F, EIF3H, and EIF3M; and module C is composed of EIF3C, EIF3D, EIF3E, EIF3K and EIF3L. EIF3C of
module C binds EIF3B of module A and EIF3H of module B, thereby linking the three modules. EIF3J is a labile
subunit that binds to the eIF-3 complex via EIF3B. The eIF-3 complex interacts with RPS6KB1 under conditions of
nutrient depletion. Mitogenic stimulation leads to binding and activation of a complex composed of MTOR and
RPTOR, leading to phosphorylation and release of RPS6KB1 and binding of EIF4B to eIF-3. Also interacts with UPF2
Mass spectrometry: Mass=93093.7; Method=Unknown; Range=1-814; Source=PubMed:17322308;
Mass spectrometry: Mass=92561; Mass_error=43.5; Method=MALDI; Range=1-814; Source=PubMed:18599441;
2 PDB 3D structures from and Proteopedia for EIF3B:
2KRB (3D)        2NLW (3D)    
Secondary accessions: A4D208 Q2NL77 Q9UMF9
Alternative splicing: 2 isoforms:  P55884-1   P55884-2   

Explore the universe of human proteins at neXtProt for EIF3B: NX_P55884

Explore proteomics data for EIF3B at MOPED

Post-translational modifications: 

  • Phosphorylated. Phosphorylation is enhanced upon serum stimulation1
  • Ubiquitination2 at Lys209, Lys230, Lys257, Lys288, Lys324, Lys345, Lys364, Lys516, Lys535, Lys552,
                                 Lys604, Lys718, Lys729, Lys744, Lys762
  • Modification sites at PhosphoSitePlus

  • See EIF3B Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001032360.1  NP_003742.2  

    ENSEMBL proteins: 
     ENSP00000408062   ENSP00000354125   ENSP00000407785   ENSP00000380206  
    Reactome Protein details: P55884

    EIF3B Human Recombinant Protein Products:

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    Browse Sino Biological Cell Lysates
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    Cloud-Clone Corp. Proteins for EIF3B

     
    Search eBioscience for Proteins for EIF3B 

    EIF3B Antibody Products:

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    Search for Antibodies for EIF3B at Abcam
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    ThermoFisher Antibodies for EIF3B
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    EIF3B Assay Products:

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    Cloud-Clone Corp. ELISAs for EIF3B
    Cloud-Clone Corp. CLIAs for EIF3B
    Search eBioscience for ELISAs for EIF3B 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    RBM: RNA binding motif (RRM) containing

    5 InterPro protein domains:
     IPR013979 TIF_beta_prop-like
     IPR000504 RRM_dom
     IPR012677 Nucleotide-bd_a/b_plait
     IPR015943 WD40/YVTN_repeat-like_dom
     IPR011400 EIF3B

    Graphical View of Domain Structure for InterPro Entry P55884

    ProtoNet protein and cluster: P55884

    2 Blocks protein domains:
    IPB000504 RNA-binding region RNP-1 (RNA recognition motif)
    IPB013979 Eukaryotic translation initiation factor 2A


    UniProtKB/Swiss-Prot: EIF3B_HUMAN, P55884
    Domain: The RRM domain mediates interaction with EIF3J
    Similarity: Belongs to the eIF-3 subunit B family
    Similarity: Contains 1 RRM (RNA recognition motif) domain
    Similarity: Contains 5 WD repeats


    Find genes that share domains with EIF3B           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: EIF3B_HUMAN, P55884
    Function: Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for
    several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and
    facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S preinitiation
    complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG
    recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal
    complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation

         Gene Ontology (GO): Selected molecular function terms (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000166nucleotide binding IEA--
    GO:0003676nucleic acid binding ----
    GO:0003723RNA binding ----
    GO:0003743contributes to translation initiation factor activity IDA17581632
    GO:0005515protein binding IPI11169732
         
    Find genes that share ontologies with EIF3B           About GenesLikeMe


    Phenotypes:
         5 GenomeRNAi human phenotypes for EIF3B:
     Decreased G3BP1 protein expres  Decreased viability of wild-ty  Increased cell death in HCT116  Nuclear 60S biogenesis defects 
     Nucleolar pre-40S maturation d 

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for EIF3B
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for EIF3B
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for EIF3B

    miRNA
    Products:
        
    miRTarBase miRNAs that target EIF3B:
    hsa-mir-151a-3p (MIRT043600), hsa-mir-92a-3p (MIRT049064), hsa-mir-615-3p (MIRT039779), hsa-mir-877-3p (MIRT036964), hsa-mir-222-3p (MIRT046746), hsa-mir-423-3p (MIRT042468), hsa-mir-324-3p (MIRT042887), hsa-mir-124-3p (MIRT022932)

    Block miRNA regulation of human, mouse, rat EIF3B using miScript Target Protectors
    6 qRT-PCR Assays for microRNAs that regulate EIF3B:
    hsa-miR-3140-3p hsa-miR-124 hsa-miR-198 hsa-miR-525-5p hsa-miR-506 hsa-miR-520a-5p
    SwitchGear 3'UTR luciferase reporter plasmidEIF3B 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for EIF3B
    Predesigned siRNA for gene silencing in human, mouse, rat EIF3B

    Gene Editing
    Products:
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    Clone
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    GenScript: all cDNA clones in your preferred vector (see all 2): EIF3B (NM_003751)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for EIF3B
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat EIF3B

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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for EIF3B


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    EIF3B_HUMAN, P55884: Cytoplasm (By similarity)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol4
    nucleus3

    Gene Ontology (GO): 5 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005829cytosol TAS--
    GO:0005852eukaryotic translation initiation factor 3 complex IDA17322308
    GO:0016282eukaryotic 43S preinitiation complex IEA--
    GO:0033290eukaryotic 48S preinitiation complex IEA--
    GO:0070062extracellular vesicular exosome IDA--

    Find genes that share ontologies with EIF3B           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for EIF3B About   (see all 6)  
    See pathways by source

    SuperPathContained pathways About
    1Influenza Viral RNA Transcription and Replication
    L13a-mediated translational silencing of Ceruloplasmin expression0.94
    Cap-dependent Translation Initiation0.89
    Formation of a pool of free 40S subunits0.94
    Eukaryotic Translation Initiation0.89
    GTP hydrolysis and joining of the 60S ribosomal subunit0.93
    Translation0.82
    2Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S
    Translation initiation complex formation0.91
    Formation of the ternary complex, and subsequently, the 43S complex0.91
    Ribosomal scanning and start codon recognition0.91
    Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S0.90
    3Gene Expression
    Gene Expression0.40
    4Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein
    Metabolism of proteins0.30
    5Translation Factors
    Translation Factors


    Find genes that share SuperPaths with EIF3B           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    2 Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for EIF3B
        eIF2 Pathway
    mTOR Pathway

    1 BioSystems Pathway for EIF3B
        Translation Factors

    Selected Reactome Pathways for EIF3B (see all 6)
        Formation of the ternary complex, and subsequently, the 43S complex
    L13a-mediated translational silencing of Ceruloplasmin expression
    GTP hydrolysis and joining of the 60S ribosomal subunit
    Ribosomal scanning and start codon recognition
    Formation of a pool of free 40S subunits


    1 Kegg Pathway  (Kegg details for EIF3B):
        RNA transport

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for EIF3B
    Interactions:

        Search GeneGlobe Interaction Network for EIF3B

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for EIF3B (P558841, 2, 3 ENSP000003541254) via UniProtKB, MINT, STRING, and/or I2D (see all 843)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    HIST1H4AP628053I2D: score=1 
    HIST1H4BP628053I2D: score=1 
    HIST1H4CP628053I2D: score=1 
    HIST1H4DP628053I2D: score=1 
    HIST1H4EP628053I2D: score=1 
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001731formation of translation preinitiation complex IEA--
    GO:0006412translation TAS--
    GO:0006413translational initiation TAS--
    GO:0006446regulation of translational initiation IDA8995410
    GO:0010467gene expression TAS--

    Find genes that share ontologies with EIF3B           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for EIF3B



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for EIF3B gene (2 alternative transcripts): 
    NM_001037283.1  NM_003751.3  

    Unigene Cluster for EIF3B:

    Eukaryotic translation initiation factor 3, subunit B
    Hs.371001  [show with all ESTs]
    Unigene Representative Sequence: AB209381
    12 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000431643 ENST00000360876(uc003slx.3 uc003sly.3 uc003slz.1)
    ENST00000413917 ENST00000397011(uc003sma.3) ENST00000463229 ENST00000463026
    ENST00000468250 ENST00000466199 ENST00000475415 ENST00000468611(uc003smb.3)
    ENST00000465670 ENST00000494658
    miRNA
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    6 qRT-PCR Assays for microRNAs that regulate EIF3B:
    hsa-miR-3140-3p hsa-miR-124 hsa-miR-198 hsa-miR-525-5p hsa-miR-506 hsa-miR-520a-5p
    SwitchGear 3'UTR luciferase reporter plasmidEIF3B 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat EIF3B
    Clone
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    GenScript: all cDNA clones in your preferred vector (see all 2): EIF3B (NM_003751)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for EIF3B
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat EIF3B
    Primer
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    OriGene qPCR primer pairs and template standards for EIF3B
    OriGene qSTAR qPCR primer pairs in human, mouse for EIF3B
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat EIF3B
      QuantiTect SYBR Green Assays in human, mouse, rat EIF3B
      QuantiFast Probe-based Assays in human, mouse, rat EIF3B

    Additional mRNA sequence: 

    AB209381.1 AK127885.1 AK300967.1 AK302058.1 BC001173.1 BC009986.1 BC110865.1 U62583.1 
    U78525.1 

    Selected DOTS entries (see all 35):

    DT.100834695  DT.97798019  DT.100759692  DT.95173385  DT.100834690  DT.454061  DT.100730058  DT.429116 
    DT.92462641  DT.97786597  DT.203336  DT.70104982  DT.102836765  DT.100039603  DT.95305235  DT.95148198 
    DT.97864515  DT.121124337  DT.95313948  DT.100834693  DT.121124353  DT.100033517  DT.100834684  DT.100834692 

    758 AceView cDNA sequences (see top 24):

    BM919002 BC001173 AI204368 AI699769 AW613698 BU857372 CF131575 BQ184896 
    AU124102 BM790290 AW189503 BU742454 CD360052 CB158647 BQ430432 CA414423 
    BU179964 BU729506 BF813415 BM459410 BU520863 BG392270 BQ221471 AI677741 
    AU134271 BU631424 BF770052 BU184482 BQ674817 BQ883620 BU538311 BU175745 
    AI651395 AI184631 BU849141 BQ049788 BQ068469 BQ951011 BU157891 BU956074 
    BP368238 CB136374 BM851047 AA233940 BE900418 AA317389 CB163685 AU141079 
    AI146462 BG679127 AA308795 CA407698 BQ055760 BM560380 BM852220 BG741900 
    BU145769 BI768671 BU196873 AU117743 CD673945 BE890169 BM715292 CK820332 
    AI917167 BQ008308 BQ059640 BQ962554 BG576318 CA307034 AI674885 BQ278601 
    BU184533 BU191062 BE905387 BQ643260 BG260460 CF455722 BU857233 CB115033 
    AI917315 AI061207 AU124308 T30307 BM916331 AI336324 BF108826 BU855360 
    BG232076 NM_003751 AW402799 AW674009 BU619877 BI910269 BU956501 BU860027 
    BQ220582 BQ428348 AI590828 AW006622 NM_182712 CR603939 BQ055964 BQ218083 
    AA362023 BU194506 BG481207 BU195154 AI160080 BU738863 BQ277728 AW250679 
    BU539785 AA488488 BM550181 CR603885 AI825123 AW473838 AU123908 CB109431 
    BQ015102 CB123612 CA313146 BM915884 CA487473 BQ055044 BM455055 BU856686 
    BG231877 BM764889 CD673946 BQ947933 BX113390 BQ217164 BU944742 BM803878 
    AI990399 CB162484 BQ709517 BM904776 CA434118 AW015861 AU132838 BU856627 
    BM480181 BE018042 CK820331 BU539252 CA414416 CF129633 BQ709516 BQ669015 
    AI369599 BU170360 AK093807 AU129038 BG116146 BM561549 BQ689310 BE263883 
    BM817777 BM461502 BQ233401 CD358807 BE746701 BP378635 BM473424 BM668006 
    BG248478 BQ917499 BM850982 BQ073423 AI093504 BU858271 AA404624 BQ953563 
    BU539745 CF140397 BQ689745 BG741163 BF311195 BX404747 BQ223243 AA301529 
    AA570378 F25750 AW967067 BQ431865 BI597188 BG824305 AW516174 BG328532 
    BG035087 CB996122 BG035381 CB991375 AA505648 BE271068 BQ689565 AA742211 
    AI623731 F35747 AL555877 BG036475 CA306182 BU540903 BU600913 AI083900 
    BF983419 BQ230894 BF683408 CA453776 AA088189 AI888128 AW137834 BQ922638 
    BF723621 AV655629 AA116114 R52935 BM740844 BG030909 BE281495 BE393907 
    CD654153 BI046667 BG028527 BU931515 BE908155 AA669005 BG397565 CF127835 
    BQ055933 AA314123 BG290512 BQ423745 AW408372 BG716407 BM558917 AJ708525 
    BX643321 BE894884 BQ017748 BQ050287 BQ900396 AU122993 BG166818 BP355584 
    BQ722589 BF528565 AA463907 BQ045103 AA970871 BE902063 BF198092 AW151381 
    BE743505 AA126089 BU845595 AW409951 BU172069 CA427912 BE514079 BE892954 
    BU193792 BU501863 AA552123 BE906886 BG334259 BG327541 BM556863 AU122095 
    BG774395 AL555876 AW195118 AL581202 BV205085 AA676471 BM826617 BI259907 
    BQ227351 AI084083 BE392800 BG168072 BF313258 BG170983 BM050761 BF311078 
    BG468160 CD721972 AI991032 BG677679 AA908740 BU902631 BM478034 BV199886 
    BI258838 BQ423021 BF038693 BE385024 BE393536 BG831507 BQ001994 BG477028 
    U78525 BE394644 BE292783 BM701972 AL121449 BG494774 BE904821 AA235397 
    AA552240 BQ919213 BM561944 BE382827 AW732308 BG830394 BQ945767 AA486040 
    CD370042 BI227087 BF591005 BM556498 BX341080 BM727927 BE901673 BG341912 
    BG115291 BQ953397 AI167619 BM553252 BE302737 BM740894 AW129658 BG821716 
    BG339963 BE546791 BM703542 BU146130 BQ959915 CF145841 BU183714 AW005621 
    BM821172 CF140230 CB160283 BG477085 BQ441191 AA778172 CB106090 BM696975 
    BG115662 BF347468 BQ641989 BF570200 AA541400 BG034607 BQ920488 BM019847 
    BM750760 BG107631 BG113031 AI253645 BE797023 BG420074 AW008156 BQ959241 
    BX646879 AI470034 BP344622 AA158751 BM043107 AA079742 AU136573 BG110694 
    BE786131 AA665859 CB144447 AA809842 BI160391 BM771754 BI088958 AA385526 
    CB152987 BG167893 BU180619 BG767688 BE881698 BX378706 BE906945 AI143144 
    BG396813 BF569224 BU944669 BE902722 BE261485 BF025775 U62583 AA488357 
    AA632946 BQ072014 CF126042 BG177850 BG332502 BX421103 BM715334 BI859192 
    AI199495 BE301216 AW129967 BU149363 CD617455 BM982213 AA618077 BE559849 
    AA297611 BU729638 BX345105 AI094686 BM997834 BM020442 BG034012 BG104253 
    AA813429 BG682007 BG109006 BE870034 BF982560 AA233938 BU856742 AU142395 
    BQ893913 BQ651386 BG256951 BM845451 CO406196 BG739777 AA088362 BU181802 
    BM017272 BQ670939 BU541006 BU169197 CA447846 BG767676 BX350414 BE560504 
    BE311638 AA582186 BI116228 BE278590 BC009986 BU850015 BQ186688 BG281034 
    BQ070291 BM771714 BI159903 CB105489 AA649216 BI489741 BG682350 BQ894874 
    BU686943 CB148557 T34658 BE514703 BG248381 AI683669 AA237074 CA415628 
    AK126670 AA939273 BM810277 CB133155 BI093742 AA580653 AU138091 AW117927 
    BG236181 AA617983 BE873460 BM673479 BG167192 AA382480 AU134056 AI636782 
    BE250139 BG230627 BF314448 AA563620 AW380677 AA069854 BE883786 BF316431 
    BM851419 R71705 CF142173 CO245996 AI420704 AA362769 AW872879 CA772613 
    AI735064 BG474983 H81550 AI571152 AA078608 AA523216 AA404742 BF853695 
    BF791485 BG028015 BE271280 BQ224115 H01480 AA085266 AA133315 CA433950 
    AA995931 BU844806 BE276703 BM714163 AA158750 AI871254 BM013875 AI983095 
    BQ070292 BG338604 AI963293 BE719494 C02897 BG253812 BE293405 BE397388 
    AA628138 BG120462 BE905739 BM925432 BQ270523 BI915674 AL713020 CB117303 
    AW948686 BU501538 BF316486 AL559626 BG769475 BI046850 BE867203 BF804972 
    BG112358 AA679866 BU657251 AL706581 AA659171 BF435712 AI699772 BM751002 
    BI764613 CB997422 N57726 BI046766 BG178238 BI046666 BF663062 AA410782 
    BQ300572 AA078364 AA115255 AA133730 BG622080 AA219668 BE305079 BI117218 
    BG422811 AA053087 AA224817 BG252113 BQ340026 BF526163 BE265461 AA236873 
    AU155335 N23233 BQ720621 AI683222 AA628539 CO249172 BE910193 BE513058 
    BG325094 AA133729 AU157465 BF125247 AL706593 BG482038 AA209528 AI766754 
    BI046146 T86402 BE261046 AA994427 AI611443 AA720530 BQ216625 BG252112 
    AI951255 BI046127 BF971955 BQ899255 AW247372 BF345123 BI045847 BQ549973 
    AW382605 BE719551 BI045494 AW024865 AA169790 AA532367 BE305198 BE410262 
    BX376572 BF849334 AI147837 BM449485 AW662461 AA321006 AL516018 AL530027 
    AI907183 BM707369 BE536997 AA297061 AA514273 BE733424 AA133316 AU155169 
    AU154289 AU144493 BE206861 AW674791 BQ072312 BG829950 BI046767 T86304 
    AW733097 CF141081 BU190465 BP377064 R53715 AA297919 AW579567 AA223205 
    BF738956 BF921134 BF962361 BX089491 BG116314 BE881825 AU151224 BE276396 
    BE153245 AI863874 CF141097 BE814777 AA256948 AA125967 BX440322 H30172 
    BI085798 AW579447 AW138226 BE561750 W60459 BI046425 BU857416 BU176245 
    AA078276 BG950427 BG831242 BF815624 AA426530 BI459262 AW960164 BF770044 
    CB132396 BF799441 T84174 AW391639 BF814896 BF798259 AA079743 H67231 
    AW663337 AA418901 AA625179 T60660 BQ641866 AW207523 AA228468 BF530111 
    BF674919 AU159731 AA115254 BQ446012 AA157839 BE002602 BG253176 AA729492 
    H01579 BE546441 T19283 CB998177 H28286 BQ320200 BG423105 BQ684826 
    AW368037 BG014886 BE706544 BF512712 D59393 BM974895 AA053598 BM797723 
    BU527300 BM556261 BF375300 BE908890 BE153255 BG488818 AA101685 BF331267 
    BE715197 AW884172 BX352322 BQ307622 CB996850 AW377443 AA602235 BE706672 
    BQ320179 CB997652 BE706694 BE153234 BE719496 BE715160 AA116115 BG911296 
    AW796939 BF901849 CK002744 BQ376118 BF313480 BE893954 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for EIF3B (see all 18)    About this scheme

    ExUns: 1 ^ 2 ^ 3a · 3b · 3c ^ 4a · 4b ^ 5a · 5b ^ 6a · 6b ^ 7a · 7b ^ 8a · 8b ^ 9a · 9b · 9c ^ 10 ^ 11a · 11b ^ 12a · 12b ^ 13 ^ 14 ^ 15a ·
    SP1:                                                                                            -                             -           -     -               
    SP2:                                                                                            -                             -           -     -               
    SP3:                                                                                            -                             -           -     -               
    SP4:                                                                                            -                             -           -     -               
    SP5:        -     -     -     -                                                                                                                                 

    ExUns: 15b · 15c ^ 16 ^ 17a · 17b ^ 18 ^ 19a · 19b · 19c ^ 20a · 20b ^ 21 ^ 22a · 22b ^ 23a · 23b ^ 24a · 24b · 24c
    SP1:        -           -                 -                                         -     -           -               
    SP2:        -           -                 -                                         -                                 
    SP3:        -           -                 -                                         -     -                           
    SP4:        -           -                 -                                         -     -                           
    SP5:                                                                                                                  


    ECgene alternative splicing isoforms for EIF3B

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

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    EIF3B expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GAAATAAAAG
    EIF3B Expression
    About this image


    EIF3B expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 13) fully expand
     
     Brain (Nervous System)    fully expand to see all 4 entries
             Cerebral Cortex
     
     Ovary (Reproductive System)    fully expand to see all 2 entries
             Ovarian Mesenchymal Stroma Cells Ovary Interstitium
             Oviduct
     
     Testis (Reproductive System)
             Leydig Cells Testis Interstitium
     
     Bone (Muscoskeletal System)
             Bone Marrow
     
     Trophoblast (Extraembryonic Tissues)
             Trophoblast Cells Trophoblast
    EIF3B Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    EIF3B Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.371001
        Custom PCR Arrays for EIF3B
    Primer
    Products:
    OriGene qPCR primer pairs and template standards for EIF3B
    OriGene qSTAR qPCR primer pairs in human, mouse for EIF3B
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat EIF3B
    QuantiTect SYBR Green Assays in human, mouse, rat EIF3B
    QuantiFast Probe-based Assays in human, mouse, rat EIF3B
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for EIF3B

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of eukaryotes.

    Orthologs for EIF3B gene from Selected species (see all 25)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Eif3b1 , 5 eukaryotic translation initiation factor 3, subunit more1, 5 85.01(n)1
    91.53(a)1
      5 (78.97 cM)5
    279791  NM_133916.21  NP_598677.11 
     1404193055 
    chicken
    (Gallus gallus)
    Aves EIF3B1 eukaryotic translation initiation factor 3, subunit more 78.95(n)
    88.5(a)
      769783  XM_003642142.2  XP_003642190.2 
    lizard
    (Anolis carolinensis)
    Reptilia --
    --
    Uncharacterized protein
    73(a)
    59(a)
    many → 1
    many → 1
    GL343340.1(41712-52758)
    GL343307.1(1301747-1303336)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.260732 Xenopus laevis transcribed sequence with moderate similarity more 77.37(n)    48055327 
    zebrafish
    (Danio rerio)
    Actinopterygii wufc17c012 wufc17c01 82.82(n)   324028  CA787533.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta eIF3-S91 eIF3-S9 58.46(n)
    53.67(a)
      36981  NM_166239.3  NP_725691.1 
    worm
    (Caenorhabditis elegans)
    Secernentea eif-3.B6
    Protein EIF-3.B, isoform a
    34(a)
    1 ↔ 1
    II(14795404-14798234) WBGene00001225
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes PRT1(YOR361C)4
    PRT11
    eIF3b subunit of the core complex of translation initiation more4
    PRT11
    48.34(n)1
    35.57(a)1
      15(1017652-1015361)4
    8545431, 4  NP_015006.31  NP_015006.14 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons EIF3B-21 EIF3B-2 53.14(n)
    43.26(a)
      832647  NM_122479.3  NP_568477.1 
    rice
    (Oryza sativa)
    Liliopsida Os.48992 Oryza sativa (japonica cultivar-group) cDNA clone0 more 70.36(n)    AK110143.1 


    ENSEMBL Gene Tree for EIF3B (if available)
    TreeFam Gene Tree for EIF3B (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for EIF3B gene
    1 SIMAP similar gene for EIF3B using alignment to 7 protein entries:     EIF3B_HUMAN (see all proteins):
    EIF3S9

    Find genes that share paralogs with EIF3B           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

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    Selected SNPs for EIF3B (see all 980)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 7 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs77959371,2
    C--2392502(+) cttatC/Tgtaca 2 -- us2k10--------
    rs1866445271,2
    --2392544(+) ACCTGC/TCCAAA 2 -- us2k10--------
    rs1911089171,2
    C--2392571(+) CATGAC/TGAGGA 2 -- us2k10--------
    rs1405732621,2
    --2392678(+) AGTCCC/TGGCAC 2 -- us2k10--------
    rs749343721,2
    F--2392748(+) ACACAG/ATGAGA 2 -- us2k11Minor allele frequency- A:0.03NA 120
    rs1457357701,2
    --2392785(+) TGGGCA/GCGGTG 2 -- us2k10--------
    rs624441621,2
    C,F--2392860(+) GCATAT/CTAAAA 2 -- us2k12Minor allele frequency- C:0.08NA 122
    rs1825669971,2
    --2392876(+) AGGCCC/GTGCGC 2 -- us2k10--------
    rs1418556821,2
    --2392881(+) CTGCGC/GGGTGG 2 -- us2k10--------
    rs77929341,2
    C,F--2393016(+) accctG/Atctct 2 -- us2k112Minor allele frequency- A:0.24NA WA CSA EA 374

    HapMap Linkage Disequilibrium report for EIF3B (2393721 - 2420380 bp)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for EIF3B (see all 14):    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2733848CNV Deletion23290073
    esv2663485CNV Deletion23128226
    dgv1118e201CNV Deletion23290073
    esv2424013CNV Deletion19546169
    esv2733846CNV Deletion23290073
    esv2733849CNV Deletion23290073
    esv2733845CNV Deletion23290073
    esv2140457CNV Deletion18987734
    esv1406872CNV Deletion17803354
    esv2733851CNV Deletion23290073

    Site Specific Mutation Identification with PCR Assays
    Search QIAGEN SeqTarget long-range PCR primers for resequencing EIF3B
    DNA2.0 Custom Variant and Variant Library Synthesis for EIF3B

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 603917    OMIM disorders: --


    Find genes that share disorders with EIF3B           About GenesLikeMe


    Export disorders for EIF3B gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for EIF3B gene, integrated from 10 sources (see all 88):
    (articles sorted by number of sources associating them with EIF3B)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The human homologue of the yeast Prt1 protein is an integral part of the eukaryotic initiation factor 3 complex and interacts with p170. (PubMed id 8995410)1, 2, 3, 9 Methot N.... Sonenberg N. (J. Biol. Chem. 1997)
    2. Molecular interaction between human tumor marker protein p150, the largest subunit of eIF3, and intermediate filament protein K7. (PubMed id 11169732)1, 2, 9 Lin L.... Burger M.M. (J. Cell. Biochem. 2001)
    3. Biochemical characterization of mammalian translation initiation factor 3 (eIF3). Molecular cloning reveals that p110 subunit is the mammalian homologue of Saccharomyces cerevisiae protein Prt1. (PubMed id 9388245)1, 2, 9 Chaudhuri J.... Maitra U. (J. Biol. Chem. 1997)
    4. Mass spectrometry reveals modularity and a complete subunit interaction map of the eukaryotic translation factor eIF3. (PubMed id 18599441)1, 2 Zhou M.... Robinson C.V. (Proc. Natl. Acad. Sci. U.S.A. 2008)
    5. Reconstitution reveals the functional core of mammalian eIF3. (PubMed id 17581632)1, 2 Masutani M.... Imataka H. (EMBO J. 2007)
    6. Structural characterization of the human eukaryotic initiation factor 3 protein complex by mass spectrometry. (PubMed id 17322308)1, 2 Damoc E.... Leary J.A. (Mol. Cell. Proteomics 2007)
    7. Structure of eIF3b RNA recognition motif and its interaction with eIF3j: structural insights into the recruitment of eIF3b to the 40 S ribosomal subunit. (PubMed id 17190833)1, 2 ElAntak L.... Lukavsky P.J. (J. Biol. Chem. 2007)
    8. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)1, 2 Olsen J.V....Mann M. (Cell 2006)
    9. mTOR and S6K1 mediate assembly of the translation preinitiation complex through dynamic protein interchange and ordered phosphorylation events. (PubMed id 16286006)1, 2 Holz M.K.... Blenis J. (Cell 2005)
    10. The j-subunit of human translation initiation factor eIF3 is required for the stable binding of eIF3 and its subcomplexes to 40 S ribosomal subunits in vitro. (PubMed id 14688252)1, 2 Fraser C.S....Hershey J.W.B. (J. Biol. Chem. 2004)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 8662 HGNC: 3280 AceView: EIF3S9 Ensembl:ENSG00000106263 euGenes: HUgn8662
    ECgene: EIF3B Kegg: 8662 H-InvDB: EIF3B

    (According to HUGE)
    About This Section

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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for EIF3B Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for EIF3B gene:
    Search GeneIP for patents involving EIF3B

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014 , 21 Aug 2014 , 8 Sep 2014

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