EIF3B Gene
protein-coding GIFtS: 57
GCID: GC07P002362
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eukaryotic translation initiation factor 3, subunit B(Previous names: eukaryotic translation initiation factor 3, subunit 9 eta,...)
(Previous symbol: EIF3S9)
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Aliases
for EIF3B gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Eukaryotic Translation Initiation Factor 3, Subunit B1 2 | | EIF3 P1102 3 | | EIF3S91 2 3 5 | | EIF3 P1162 3 | | PRT11 2 5 | | HPrt11 | | Eukaryotic Translation Initiation Factor 3, Subunit 9 Eta, 116kDa1 2 | | EIF3-ETA2 | | EIF3b1 | | EIF3-P1102 | | Eukaryotic Translation Initiation Factor 3 Subunit 92 3 | | EIF3-P1162 | | Prt1 Homolog2 3 | | Eukaryotic Translation Initiation Factor 3 Subunit B2 | | EIF-3-Eta1 | | Eukaryotic Translation Initiation Factor 3, Subunit 9 (Eta, 116kD)2 |
Export aliases for EIF3B gene to outside databases |
Summaries
for EIF3B gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
UniProtKB/Swiss-Prot: EIF3B_HUMAN, P55884Function: Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for severalsteps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and facilitates therecruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S preinitiation complex (43S PIC). TheeIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequentlyprevents premature joining of the 40S and 60S ribosomal subunits prior to initiation
Gene Wiki entry for EIF3B
|
Genomic Views
for EIF3B gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000007.13 NC_018918.1 NT_007819.17 NT_079592.2
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the EIF3B gene promoter:
Max1 Pax-5 NF-E2 p45 Egr-4 AREB6 Pax-4a NF-E2 ATF ATF6 c-Myc
Other transcription factors
Search SABiosciences Chromatin IP Primers for EIF3B
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat EIF3B |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 7p22.3 Ensembl cytogenetic band: 7p22.3 HGNC cytogenetic band: 7p22EIF3B Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 7 GeneLoc Exon Structure GeneLoc location for GC07P002362: view genomic region
(about GC identifiers)
Start:
|
2,393,721 bp from pter |
End:
|
2,420,380 bp from pter |
Size:
|
26,660 bases |
Orientation:
|
plus strand |
1 alternative location:
| Chr7+,CRA_TCAG 2,442,541-2,468,274 |
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Proteins
for EIF3B gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: EIF3B_HUMAN, P55884 (See
protein sequence)Recommended Name: Eukaryotic translation initiation factor 3 subunit B Size: 814 amino acids; 92482 Da
Subunit: Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is composed of 13 subunits:EIF3A, EIF3B, EIF3C, EIF3D, EIF3E, EIF3F, EIF3G, EIF3H, EIF3I, EIF3J, EIF3K, EIF3L and EIF3M. The eIF-3 complexappears to include 3 stable modules: module A is composed of EIF3A, EIF3B, EIF3G and EIF3I; module B is composed ofEIF3F, EIF3H, and EIF3M; and module C is composed of EIF3C, EIF3D, EIF3E, EIF3K and EIF3L. EIF3C of module C bindsEIF3B of module A and EIF3H of module B, thereby linking the three modules. EIF3J is a labile subunit that binds tothe eIF-3 complex via EIF3B. The eIF-3 complex interacts with RPS6KB1 under conditions of nutrient depletion.Mitogenic stimulation leads to binding and activation of a complex composed of MTOR and RPTOR, leading tophosphorylation and release of RPS6KB1 and binding of EIF4B to eIF-3. Also interacts with UPF2
Subcellular location: Cytoplasm (By similarity)
Mass spectrometry: Mass=93093.7; Method=Unknown; Range=1-814; Source=PubMed:17322308;
Mass spectrometry: Mass=92561; Mass_error=43.5; Method=MALDI; Range=1-814; Source=PubMed:18599441;
2 PDB 3D structures from  and Proteopedia  for EIF3B:2KRB (3D)
2NLW (3D)
Secondary accessions: A4D208 Q2NL77 Q9UMF9Alternative splicing: 2 isoforms: P55884-1 P55884-2 Explore the universe of human proteins at neXtProt for EIF3B: NX_P55884
Post-translational modifications:
Phosphorylated. Phosphorylation is enhanced upon serum stimulation1
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_P55884
EIF3B Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins (2 alternative transcripts):
NP_001032360.1 NP_003742.2
ENSEMBL proteins: ENSP00000408062 ENSP00000354125 ENSP00000407785 ENSP00000380206 Reactome Protein details: P55884
Human Recombinant Protein Products for EIF3B:
Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view): About this table
EIF3B for ontologies About GeneDecksing
EIF3B Antibody Products:
Assay Products for EIF3B: |
Protein
Domains /
Families
for EIF3B gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
EIF3B for domains About GeneDecksing
5 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry P55884ProtoNet protein and cluster: P55884 2 Blocks protein families: IPB000504 RNA-binding region RNP-1 (RNA recognition motif) IPB013979 Eukaryotic translation initiation factor 2A
UniProtKB/Swiss-Prot: EIF3B_HUMAN, P55884Domain: The RRM domain mediates interaction with EIF3JSimilarity: Belongs to the eIF-3 subunit B familySimilarity: Contains 1 RRM (RNA recognition motif) domainSimilarity: Contains 5 WD repeats |
Function
for EIF3B gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
inGenious Targeting Laboratory,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase,
shRNA from
OriGene,
Sirion Biotech,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Sirion Biotech,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
Sirion Biotech,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Molecular Function:
UniProtKB/Swiss-Prot Summary: EIF3B_HUMAN, P55884Function: Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for severalsteps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and facilitates therecruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S preinitiation complex (43S PIC). TheeIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequentlyprevents premature joining of the 40S and 60S ribosomal subunits prior to initiation Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view): About this table
EIF3B for ontologies About GeneDecksing
Phenotypes:
5 GenomeRNAi human phenotypes for EIF3B:
Animal Models:
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for EIF3B (see all 4)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for EIF3B (see all 3)
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector (see all 2): EIF3B (NM_003751) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for EIF3B | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat EIF3B |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for EIF3B |
|
Pathways & Interactions
for EIF3B gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways - 5/7 super-pathways (see all 7) About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | Synthesis of PB1-F2 | | | 2 | Translation initiation complex formation | | | 3 | IL-2 Signaling Pathway | | | 4 | Translation Factors | | | 5 | RNA transport | |
Pathway sources
See GeneCards unified pathways
Show all pathways
2  BioSystems Pathways for EIF3B
5/13 
Reactome Pathways for EIF3B (see all 13)
1 
Kegg Pathway (Kegg details for EIF3B):
EIF3B for pathways About GeneDecksing
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for EIF3B
STRING Interaction
Network Preview (showing 5 interactants - click image to see 25)
5/735 Interacting proteins for EIF3B (P558841, 2, 3 ENSP000003541254) via UniProtKB, MINT, STRING, and/or I2D (see all 735)About this table
Gene Ontology (GO): 5 biological process terms (GO ID links to tree view): About this table
EIF3B for ontologies About GeneDecksing
|
Drugs & Compounds
for EIF3B gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for EIF3B
Search CenterWatch for drugs/clinical trials and news about EIF3B
|
Transcripts
for EIF3B gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
Sirion Biotech,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for EIF3B gene (2 alternative transcripts): NM_001037283.1 NM_003751.3 Unigene Cluster for EIF3B: Eukaryotic translation initiation factor 3, subunit B Hs.371001 [show with all ESTs]Unigene Representative Sequence: AB20938112 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000431643 ENST00000360876(uc003slx.3 uc003sly.3 uc003slz.1)
ENST00000413917 ENST00000397011(uc003sma.3) ENST00000463229 ENST00000463026
ENST00000468250 ENST00000466199 ENST00000475415 ENST00000468611(uc003smb.3)
ENST00000465670 ENST00000494658
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for EIF3B (see all 4)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for EIF3B (see all 3)
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector (see all 2): EIF3B (NM_003751) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for EIF3B | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat EIF3B |
Additional cDNA sequence: AB209381.1 AK127885.1 AK300967.1 AK302058.1 BC001173.1 BC009986.1 BC110865.1 U62583.1 U78525.1 24/35 DOTS entries (see all 35): DT.100834695 DT.97798019 DT.100759692 DT.95173385 DT.100834690 DT.454061 DT.100730058 DT.429116 DT.92462641 DT.97786597 DT.203336 DT.70104982 DT.102836765 DT.100039603 DT.95305235 DT.95148198 DT.97864515 DT.121124337 DT.95313948 DT.100834693 DT.121124353 DT.100033517 DT.100834684 DT.100834692 758 AceView cDNA sequences (see top 24): AW613698 BQ221471 BM560380 BF108826 BQ709516 AW015861 AI825123 CB115033 AI204368 BC001173 BQ669015 CA434118 BP368238 BU175745 CD673946 BU856686 AI699769 CR603939 AI336324 BQ643260 AU124102 AW473838 BM904776 BU956074 AI369599 BM561549 BM915884 BU145769 AU129038 AA233940 CB123612 BQ220582 BQ709517 AW006622 CA307034 BU191062 BG231877 BQ430432 BQ184896 BG392270 BQ218083 AI917167 AI590828 AU124308 AI651395 T30307 BU855360 CK820331 CA414423 CB162484 AI917315 AK093807 BQ428348 CD673945 BU856627 BF813415 BX113390 BU729506 BU631424 CB158647 BQ055964 CB163685 CA487473 CF129633 BU857372 BM803878 BU860027 BQ049788 BU956501 AI146462 BQ962554 CA414416 NM_182712 BU619877 AW189503 BM851047 BU539252 BU184533 CF455722 BI768671 BQ689310 AA362023 AI990399 BQ015102 BG741900 BQ883620 BM715292 BI910269 CA407698 BU195154 BM480181 BG232076 BM459410 BG481207 BQ217164 BM461502 BU944742 BE890169 AU134271 CB136374 AU123908 BU184482 BU520863 CB109431 AI061207 BM455055 BU538311 BG260460 BU170360 NM_003751 BQ947933 BU539785 BE263883 BQ059640 AI674885 CF131575 BE018042 BM790290 AW250679 BM550181 BM764889 BU857233 BU742454 BM817777 CD360052 CK820332 CR603885 BM919002 BQ068469 BQ055044 BU738863 BG679127 BU194506 BG116146 AU117743 AU132838 BM916331 BQ951011 BU157891 BU179964 AI160080 BQ277728 BQ233401 BQ008308 BQ674817 AA317389 AW402799 BU196873 AI677741 BF770052 BQ278601 AA488488 AU141079 AW674009 BE900418 BE905387 AA308795 BM852220 BQ055760 BU849141 BG576318 CA313146 AI184631 BM556863 BG113031 AL121449 AA382480 BE385024 BQ072014 CB144447 BF198092 BU539745 BG035087 BU931515 BI160391 BX421103 AA488357 BM561944 AI636782 AW005621 BX350414 AA665859 BE392800 AA676471 BF723621 BI258838 BX643321 BE894884 CB152987 BU856742 CB996122 AA813429 BG230627 BU944669 BQ900396 F35747 CA306182 BQ953397 AU136573 AW129658 AA618077 BQ441191 AJ708525 BG236181 BG494774 BI227087 BG477085 CF140397 CB148557 BQ917499 BE881698 BE302737 AW732308 AI253645 AL581202 BE743505 BU902631 AA580653 BM810277 BV205085 BX378706 BE797023 BQ953563 AW516174 BU501863 AA552240 BU172069 BG339963 AA939273 BM478034 BE902063 AI888128 BQ227351 BQ670939 BU180619 BG332502 BQ641989 BX345105 BF528565 BE908155 BG167192 BE546791 AA116114 BQ959241 CB106090 AW195118 BI088958 BE393907 BM019847 BE261485 BM740844 AI623731 BE560504 BG248381 BG034012 BI116228 AA297611 BU845595 BI159903 AW008156 BE281495 BQ055933 BQ431865 BF570200 BG328532 BG167893 CB160283 BE892954 AA301529 BE906945 BM020442 BI093742 CO406196 BE873460 AA486040 BF347468 AA088362 BM703542 BU149363 BQ423021 BM043107 AA158751 BU169197 BU686943 AW129967 BM556498 AA778172 BM701972 BQ651386 BQ689565 AA233938 BM558917 BG830394 AA541400 BU858271 AA669005 BU600913 AI093504 BE559849 BQ223243 BQ920488 BQ230894 BM771754 R52935 BI597188 AW967067 AA649216 AA463907 BM673479 BI489741 BU540903 BU850015 BM740894 BM017272 BG168072 AA908740 BG028527 BI046667 BG170983 BP344622 AI470034 CF126042 AL555876 AA742211 BG248478 BG104253 BE292783 BG821716 BE906886 AA385526 BM050761 CA447846 BM997834 U62583 BG831507 CD370042 BQ922638 CD654153 F25750 AA237074 BG036475 CF140230 BG420074 BU193792 BM821172 BM553252 U78525 BG477028 BF038693 BG281034 AA088189 BF025775 T34658 BE301216 BF683408 BG115291 CF127835 AL555877 AU122095 AA079742 AA552123 BE393536 BQ045103 BU729638 BE271068 BE746701 BU146130 BQ919213 BQ070291 BM750760 BE786131 BV199886 BG716407 BG030909 AU134056 AK126670 BM668006 BQ689745 AV655629 BG682007 BI259907 AA126089 BG334259 BF982560 AA970871 AI683669 BG034607 AI094686 BG767676 CD721972 BG327541 BQ893913 BU541006 BG677679 BE902722 BG110694 BF311078 AW408372 CB105489 BG397565 BP378635 BM696975 BM727927 BF313258 CD358807 BQ050287 BG767688 AU142395 AW137834 BE250139 BM715334 BE904821 BF591005 BG177850 BF311195 BE278590 BX341080 BC009986 BM826617 CF145841 BQ186688 BE901673 BM771714 AA632946 BQ073423 BQ959915 BE870034 BQ945767 BG682350 BG824305 BI859192 BQ017748 BF569224 BG109006 BE311638 BX404747 BG290512 AA505648 AI991032 AA314123 BG739777 AI167619 BM845451 AA809842 BQ001994 CB991375 BE514079 BG341912 CA427912 BQ423745 BM982213 AA235397 BG035381 BP355584 BG256951 AA570378 BE382827 BE514703 AI083900 BE394644 BG115662 AW117927 AI199495 AU138091 AU122993 AA582186 BX646879 BU183714 BQ722589 CA415628 CA453776 BG741163 BG166818 AI143144 AA617983 BQ894874 BM473424 BG107631 CD617455 BG396813 BU181802 BG468160 AA404624 AI084083 BG774395 CB133155 AW151381 AW409951 BM850982 BF983419 AA659171 BF526163 BG622080 AA995931 AL713020 BF125247 H01480 CA433950 BI046666 BG178238 AI871254 AI420704 CB997422 BI046766 BF314448 BG028015 BE305079 BF663062 BU657251 BE265461 AA219668 BE293405 AA078364 BG769475 AI735064 AA628539 N23233 AA078608 BF316431 CF142173 AL706593 CO249172 BG120462 AA158750 BM751002 AA133315 BM714163 BI764613 BI046850 BE271280 AA133729 BE905739 AI571152 BE867203 AI983095 BG252113 BE397388 AA085266 BQ720621 AL559626 CO245996 AW872879 BG112358 BG325094 AA362769 BF853695 AA679866 AW380677 BQ270523 BF791485 AA236873 AL706581 BU844806 AW948686 BQ224115 BG482038 BG422811 BI117218 BE910193 BI915674 AA410782 BF804972 BQ300572 AI683222 AA133730 BF435712 BM013875 BG474983 BU501538 BG253812 AA053087 AA404742 AA069854 AI963293 N57726 BE513058 BQ340026 CB117303 AA628138 BE719494 AA563620 BM925432 BF316486 BG338604 H81550 BE276703 C02897 AI699772 AA523216 AA224817 BE883786 BM851419 BQ070292 AU155335 CA772613 AU157465 R71705 AA115255 BQ899255 AW024865 AI147837 BE305198 AA297061 BQ072312 BM449485 AU144493 AI951255 BM707369 BI046127 BQ216625 AL516018 BG829950 AW662461 AW733097 AA209528 BE719551 AI766754 BE536997 T86402 AU154289 AU155169 BF849334 BI045494 AA133316 AL530027 AW247372 T86304 AA994427 CF141081 BF345123 AW382605 AA514273 AA720530 BI045847 BU190465 BE206861 BP377064 BE733424 BI046146 BE410262 BF971955 AI611443 BQ549973 AW674791 AA321006 R53715 BX376572 AA169790 BE261046 AI907183 BI046767 BG252112 AA532367 AI863874 BE153245 BF921134 BF799441 BG116314 BE561750 BX440322 BF738956 H30172 BE881825 CB132396 BU176245 AA078276 BG950427 AW579567 AA223205 BE814777 CF141097 BF962361 BX089491 AU151224 BI459262 BU857416 AW138226 BG831242 BI046425 AW960164 BF770044 W60459 BI085798 AA125967 AA426530 AA256948 AW579447 BE276396 BF815624 T84174 AA297919 BG253176 T60660 BF814896 BF674919 H01579 AA157839 AU159731 AW391639 BQ446012 BE002602 AA115254 AW663337 AA729492 AA625179 AW207523 AA418901 H67231 AA079743 BQ641866 BF798259 BF530111 AA228468 BE706544 BQ320200 BM797723 BU527300 T19283 BE153255 BE908890 BM974895 BM556261 D59393 BG014886 BE546441 BF512712 BF375300 H28286 AW368037 BG488818 BG423105 AA101685 CB998177 BQ684826 AA053598 BX352322 BQ320179 BQ307622 AW884172 CB997652 BG911296 BF331267 BE706694 AA116115 BE153234 AW377443 BE719496 BE706672 BF901849 AA602235 CB996850 AW796939 BE715160 BE715197 BF313480 CK002744 BQ376118 BE893954
GeneLoc Exon Structure
5/18 Alternative Splicing Database (ASD) splice patterns (SP) for EIF3B (see all 18) About this scheme
| ExUns: | 1 | ^ | 2 | ^ | 3a | · | 3b | · | 3c | ^ | 4a | · | 4b | ^ | 5a | · | 5b | ^ | 6a | · | 6b | ^ | 7a | · | 7b | ^ | 8a | · | 8b | ^ | 9a | · | 9b | · | 9c | ^ | 10 | ^ | 11a | · | 11b | ^ | 12a | · | 12b | ^ | 13 | ^ | 14 | ^ | 15a | · |
|---|
|
| SP1: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | - | | | | | | | | | | - | | | | - | | - | | | | | | |
| SP2: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | - | | | | | | | | | | - | | | | - | | - | | | | | | |
| SP3: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | - | | | | | | | | | | - | | | | - | | - | | | | | | |
| SP4: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | - | | | | | | | | | | - | | | | - | | - | | | | | | |
| SP5: | | | - | | - | | - | | - | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| ExUns: | 15b | · | 15c | ^ | 16 | ^ | 17a | · | 17b | ^ | 18 | ^ | 19a | · | 19b | · | 19c | ^ | 20a | · | 20b | ^ | 21 | ^ | 22a | · | 22b | ^ | 23a | · | 23b | ^ | 24a | · | 24b | · | 24c |
|---|
|
| SP1: | | | - | | | | - | | | | | | - | | | | | | | | | | | | | | - | | - | | | | - | | | | | | |
| SP2: | | | - | | | | - | | | | | | - | | | | | | | | | | | | | | - | | | | | | | | | | | | |
| SP3: | | | - | | | | - | | | | | | - | | | | | | | | | | | | | | - | | - | | | | | | | | | | |
| SP4: | | | - | | | | - | | | | | | - | | | | | | | | | | | | | | - | | - | | | | | | | | | | |
| SP5: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
ECgene alternative splicing isoforms for EIF3B
|
Expression
for EIF3B gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| EIF3B expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GAAATAAAAG
About this image
See EIF3B Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for EIF3B
SOURCE GeneReport for Unigene cluster: Hs.371001
SABiosciences Custom PCR Arrays for EIF3B
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for EIF3B
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat EIF3B | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat EIF3B | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat EIF3B | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for EIF3B |
Orthologs
for EIF3B gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of eukaryotes.
Orthologs for EIF3B gene from 9/36 species (see all 36) About this table
ENSEMBL Gene Tree for EIF3B (if available)
TreeFam Gene Tree for EIF3B (if available) |
Paralogs
for EIF3B gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| -- |
Genomic Variants
for EIF3B gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 7 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for EIF3B (2393721 - 2420380 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 9 variations for EIF3B
2 CNVs: 69768 99846
7 Indels: 94341 12902 81845 69769 12901 28608 12900 | SABiosciences Cancer Mutation PCR Assays |
|
Disorders
/ Diseases
for EIF3B gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
EIF3B for disorders About GeneDecksing
OMIM gene information: 603917
OMIM disorders: --
4  diseases for EIF3B: About MalaCardsmouth disease tetralogy of fallot melanoma malaria
Export disorders for EIF3B gene to outside databases
|
Publications
for EIF3B gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for EIF3B gene, integrated from 9 sources (see all 73):
(articles sorted by number of sources associating them with EIF3B) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- The human homologue of the yeast Prt1 protein is an integral part of the eukaryotic initiation factor 3 complex and interacts with p170. (PubMed id 8995410)1, 2, 3, 9 Methot N.... Sonenberg N. (1997)
- Molecular interaction between human tumor marker protein p150, the largest subunit of eIF3, and intermediate filament protein K7. (PubMed id 11169732)1, 2, 9 Lin L.... Burger M.M. (2001)
- Biochemical characterization of mammalian translation initiation factor 3 (eIF3). Molecular cloning reveals that p110 subunit is the mammalian homologue of Saccharomyces cerevisiae protein Prt1. (PubMed id 9388245)1, 2, 9 Chaudhuri J.... Maitra U. (1997)
- Mass spectrometry reveals modularity and a complete subunit interaction map of the eukaryotic translation factor eIF3. (PubMed id 18599441)1, 2 Zhou M....Robinson C.V. (2008)
- Reconstitution reveals the functional core of mammalian eIF3. (PubMed id 17581632)1, 2 Masutani M.... Imataka H. (2007)
- Structural characterization of the human eukaryotic initiation factor 3 protein complex by mass spectrometry. (PubMed id 17322308)1, 2 Damoc E....Leary J.A. (2007)
- Structure of eIF3b RNA recognition motif and its interaction with eIF3j: structural insights into the recruitment of eIF3b to the 40 S ribosomal subunit. (PubMed id 17190833)1, 2 ElAntak L.... Lukavsky P.J. (2007)
- Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)1, 2 Olsen J.V....Mann M. (2006)
- mTOR and S6K1 mediate assembly of the translation preinitiation complex through dynamic protein interchange and ordered phosphorylation events. (PubMed id 16286006)1, 2 Holz M.K.... Blenis J. (2005)
- The j-subunit of human translation initiation factor eIF3 is required for the stable binding of eIF3 and its subcomplexes to 40 S ribosomal subunits in vitro. (PubMed id 14688252)1, 2 Fraser C.S....Hershey J.W. (2004)
|
External Searches for EIF3B gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing EIF3B gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing EIF3B gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing EIF3B gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for EIF3B | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for EIF3B gene:
Search GeneIP for patents involving EIF3B
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for EIF3B gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory)
About This Section
|
 | |
 | |
 |
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| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for EIF3B |
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