Aliases for EIF3B Gene
External Ids for EIF3B Gene
Previous HGNC Symbols for EIF3B Gene
Previous GeneCards Identifiers for EIF3B Gene
GeneCards Summary for EIF3B Gene
EIF3B (Eukaryotic Translation Initiation Factor 3 Subunit B) is a Protein Coding gene. Among its related pathways are p70S6K Signaling and Viral mRNA Translation. GO annotations related to this gene include nucleic acid binding and nucleotide binding.
UniProtKB/Swiss-Prot for EIF3B Gene
Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation.
(Microbial infection) In case of FCV infection, plays a role in the ribosomal termination-reinitiation event leading to the translation of VP2 (PubMed:18056426).