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EIF3A Gene

protein-coding   GIFtS: 65
GCID: GC10M120794

Eukaryotic Translation Initiation Factor 3, Subunit A

(Previous names: eukaryotic translation initiation factor 3, subunit 10 theta,...)
(Previous symbols: EIF3, EIF3S10)
Microbiology & Infectious Diseases Congress
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at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Eukaryotic Translation Initiation Factor 3, Subunit A1 2     Cytoplasmic Protein P1672
EIF3S101 2 3 5     eIF3-p1702
EIF31 2     eIF3-theta2
Eukaryotic Translation Initiation Factor 3, Subunit 10 Theta, 150/170kDa1 2     EIF3, P180 Subunit2
Eukaryotic Translation Initiation Factor 3 Subunit 102 3     Eukaryotic Translation Initiation Factor 3 Subunit A2
eIF-3-theta2 3     Eukaryotic Translation Initiation Factor 3, Subunit 10 (Theta, 150/170kD)2
EIF3 P1672 3     Eukaryotic Translation Initiation Factor 3, Subunit 10 (Theta, 170kD)2
EIF3 P1802 3     Eukaryotic Translation Initiation Factor 3, Subunit 10, 170kD2
EIF3 P1852 3     p1802
P1672 5     p1852
TIF322     KIAA01393
Centrosomin Homolog2     eIF3a3

External Ids:    HGNC: 32711   Entrez Gene: 86612   Ensembl: ENSG000001075817   OMIM: 6020395   UniProtKB: Q141523   

Export aliases for EIF3A gene to outside databases

Previous GC identifers: GC10M120785 GC10M114423


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for EIF3A Gene:
EIF3A (eukaryotic translation initiation factor 3, subunit A) is a protein-coding gene. Diseases associated with EIF3A include noma, and bardet-biedl syndrome. GO annotations related to this gene include structural molecule activity and translation initiation factor activity.

UniProtKB/Swiss-Prot: EIF3A_HUMAN, Q14152
Function: Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for
several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and
facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S preinitiation
complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG
recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal
complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation

Gene Wiki entry for EIF3A Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000010.11  NC_018921.2  NT_030059.14  
Regulatory elements:
   Regulatory transcription factor binding sites in the EIF3A gene promoter:
         HOXA3   Pax-5   Nkx2-2   CUTL1   Tal-1beta   Arnt   E47   PPAR-gamma1   PPAR-gamma2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidEIF3A promoter sequence
   Search Chromatin IP Primers for EIF3A

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat EIF3A


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 10q26   Ensembl cytogenetic band:  10q26.11   HGNC cytogenetic band: 10q26.11

EIF3A Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
EIF3A gene location

GeneLoc information about chromosome 10         GeneLoc Exon Structure

GeneLoc location for GC10M120794:  view genomic region     (about GC identifiers)

Start:
120,794,356 bp from pter      End:
120,840,334 bp from pter
Size:
45,979 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: EIF3A_HUMAN, Q14152 (See protein sequence)
Recommended Name: Eukaryotic translation initiation factor 3 subunit A  
Size: 1382 amino acids; 166569 Da
Subunit: Interacts with EIF4G1 (By similarity). Component of the eukaryotic translation initiation factor 3
(eIF-3) complex, which is composed of 13 subunits: EIF3A, EIF3B, EIF3C, EIF3D, EIF3E, EIF3F, EIF3G, EIF3H, EIF3I,
EIF3J, EIF3K, EIF3L and EIF3M. The eIF-3 complex appears to include 3 stable modules: module A is composed of
EIF3A, EIF3B, EIF3G and EIF3I; module B is composed of EIF3F, EIF3H, and EIF3M; and module C is composed of
EIF3C, EIF3D, EIF3E, EIF3L and EIF3K. EIF3C of module C binds EIF3B of module A and EIF3H of module B, thereby
linking the three modules. EIF3J is a labile subunit that binds to the eIF-3 complex via EIF3B. The eIF-3 complex
interacts with RPS6KB1 under conditions of nutrient depletion. Mitogenic stimulation leads to binding and
activation of a complex composed of MTOR and RPTOR, leading to phosphorylation and release of RPS6KB1 and binding
of EIF4B to eIF-3. Also interacts with KRT7 and PIWIL2
Mass spectrometry: Mass=166758.3; Method=Unknown; Range=1-1382; Source=PubMed:17322308;
Sequence caution: Sequence=BAA09488.2; Type=Erroneous initiation;
Secondary accessions: B1AMV5 O00653 Q15778

Explore the universe of human proteins at neXtProt for EIF3A: NX_Q14152

Explore proteomics data for EIF3A at MOPED

Post-translational modifications: 

  • Phosphorylated. Phosphorylation is enhanced upon serum stimulation1
  • Ubiquitination2 at Lys13, Lys45, Lys68, Lys75, Lys351, Lys409, Lys420, Lys672, Lys711, Lys775,
                                 Lys777
  • Modification sites at PhosphoSitePlus

  • See EIF3A Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_003741.1  
    ENSEMBL proteins: 
     ENSP00000358140   ENSP00000438178  
    Reactome Protein details: Q14152

    EIF3A Human Recombinant Protein Products:

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    Cloud-Clone Corp. Proteins for EIF3A

    EIF3A Antibody Products:

    EMD Millipore Mono- and Polyclonal Antibodies for the study of EIF3A
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    Abcam antibodies for EIF3A (P56537, Q14152)
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    LSBio Antibodies in human, mouse, rat for EIF3A

    EIF3A Assay Products:

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    Cloud-Clone Corp. CLIAs for EIF3A


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    2 InterPro protein domains:
     IPR000717 PCI_dom
     IPR027512 EIF3A

    Graphical View of Domain Structure for InterPro Entry Q14152

    ProtoNet protein and cluster: Q14152

    1 Blocks protein domain: IPB000717 Domain in components of the proteasome

    UniProtKB/Swiss-Prot: EIF3A_HUMAN, Q14152
    Similarity: Belongs to the eIF-3 subunit A family
    Similarity: Contains 1 PCI domain


    EIF3A for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: EIF3A_HUMAN, Q14152
    Function: Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for
    several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and
    facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S preinitiation
    complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG
    recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal
    complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation

         Gene Ontology (GO): 4 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003743contributes to translation initiation factor activity IDA17581632
    GO:0005198structural molecule activity NAS9150439
    GO:0005515protein binding IPI11169732
    GO:0044822poly(A) RNA binding IDA--
         
    EIF3A for ontologies           About GeneDecksing


    Phenotypes:
         12 GenomeRNAi human phenotypes for EIF3A:
     Cell division defect  Decreased Wnt reporter activit  Decreased cell number, increas  Decreased homologous recombina 
     Decreased influenza A H1N1 (A/  Decreased influenza A H1N1 (A/  Decreased influenza A/WSN/33 r  Decreased viability of wild-ty 
     Increased cell death in HCT116  Increased gamma-H2AX phosphory  S arrest  Synthetic lethal with Ras 

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for EIF3A
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for EIF3A
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for EIF3A

    miRNA
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    miRTarBase miRNAs that target EIF3A:
    hsa-mir-92b-3p (MIRT040734), hsa-mir-16-5p (MIRT031705), hsa-mir-18a-3p (MIRT040974), hsa-mir-155-5p (MIRT020771), hsa-mir-484 (MIRT042324), hsa-let-7c-5p (MIRT051776)

    Block miRNA regulation of human, mouse, rat EIF3A using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate EIF3A (see all 26):
    hsa-miR-3910 hsa-miR-148b* hsa-miR-136 hsa-miR-15a hsa-miR-488 hsa-miR-500a hsa-miR-1297 hsa-miR-3159
    SwitchGear 3'UTR luciferase reporter plasmidEIF3A 3' UTR sequence
    Inhib. RNA
    Products:
        
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    Predesigned siRNA for gene silencing in human, mouse, rat EIF3A

    Gene Editing
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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for EIF3A


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    EIF3A_HUMAN, Q14152: Cytoplasm
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol4
    nucleus4
    plasma membrane2
    cytoskeleton1
    extracellular1

    Gene Ontology (GO): Selected cellular component terms (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA--
    GO:0005730nucleolus IDA--
    GO:0005737cytoplasm NAS9150439
    GO:0005829cytosol TAS--
    GO:0005852eukaryotic translation initiation factor 3 complex IDA17322308

    EIF3A for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for EIF3A About   (see all 8)                                                                                              See pathways by source

    SuperPathContained pathways About
    1Influenza Viral RNA Transcription and Replication
    L13a-mediated translational silencing of Ceruloplasmin expression0.94
    Cap-dependent Translation Initiation0.89
    Formation of a pool of free 40S subunits0.94
    Eukaryotic Translation Initiation0.89
    GTP hydrolysis and joining of the 60S ribosomal subunit0.93
    Translation0.82
    2Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S
    Translation initiation complex formation0.91
    Formation of the ternary complex, and subsequently, the 43S complex0.91
    Ribosomal scanning and start codon recognition0.91
    Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S0.90
    3Gene Expression
    Gene Expression0.40
    4IL2 signaling events mediated by PI3K
    IL2 signaling events mediated by PI3K0.34
    5Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein
    Metabolism of proteins0.30

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    2 Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for EIF3A
        eIF2 Pathway
    mTOR Pathway

    1 Cell Signaling Technology (CST) Pathway for EIF3A
        Translational Control

    2 BioSystems Pathways for EIF3A
        Translation Factors
    IL2 signaling events mediated by PI3K

    Selected Reactome Pathways for EIF3A (see all 6)
        Formation of the ternary complex, and subsequently, the 43S complex
    L13a-mediated translational silencing of Ceruloplasmin expression
    GTP hydrolysis and joining of the 60S ribosomal subunit
    Ribosomal scanning and start codon recognition
    Formation of a pool of free 40S subunits


    1 Kegg Pathway  (Kegg details for EIF3A):
        RNA transport


    EIF3A for pathways           About GeneDecksing

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for EIF3A
    Interactions:

        GeneGlobe Interaction Network for EIF3A

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for EIF3A (Q141521, 2, 3 ENSP000003581404) via UniProtKB, MINT, STRING, and/or I2D (see all 319)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    HIST1H4AP628053I2D: score=1 
    HIST1H4BP628053I2D: score=1 
    HIST1H4CP628053I2D: score=1 
    HIST1H4DP628053I2D: score=1 
    HIST1H4EP628053I2D: score=1 
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001731formation of translation preinitiation complex IEA--
    GO:0001732formation of translation initiation complex IDA17581632
    GO:0006412translation TAS--
    GO:0006413translational initiation TAS--
    GO:0006446regulation of translational initiation IEA--

    EIF3A for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for EIF3A

    8 Novoseek inferred chemical compound relationships for EIF3A gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    thiosemicarbazide 66.1 2 8995410 (1), 9341143 (1)
    mimosine 57.2 2 12972576 (1), 15855174 (1)
    rapamycin 18 4 16541103 (1), 15946946 (1), 18174256 (1)
    ribonucleic acid 16.6 1 1972345 (1)
    tyrosine 13.4 15 7728765 (3), 7909494 (2), 7678546 (1), 10473599 (1) (see all 6)
    gtp 1.01 1 12762043 (1)
    phosphatidylinositol 0 2 8999900 (1)
    serine 0 1 18174256 (1)



    EIF3A for compounds           About GeneDecksing



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for EIF3A gene: 
    NM_003750.2  

    Unigene Cluster for EIF3A:

    Eukaryotic translation initiation factor 3, subunit A
    Hs.523299  [show with all ESTs]
    Unigene Representative Sequence: NM_003750
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000369144(uc010qsu.2 uc001ldu.3) ENST00000462527 ENST00000541549(uc009xzg.1)

    Congresses - knowledge worth sharing:
    European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

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    Selected qRT-PCR Assays for microRNAs that regulate EIF3A (see all 26):
    hsa-miR-3910 hsa-miR-148b* hsa-miR-136 hsa-miR-15a hsa-miR-488 hsa-miR-500a hsa-miR-1297 hsa-miR-3159
    SwitchGear 3'UTR luciferase reporter plasmidEIF3A 3' UTR sequence
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      QuantiFast Probe-based Assays in human, mouse, rat EIF3A

    Additional mRNA sequence: 

    AK097145.1 AK302575.1 AK307610.1 AK309542.1 BC020285.1 BC033769.1 BC054342.1 BC064926.1 
    BC107776.1 BC114429.1 D50929.1 JX312508.1 U58046.1 U78311.1 

    Selected DOTS entries (see all 26):

    DT.419410  DT.91675275  DT.100828397  DT.100828392  DT.100798858  DT.95365651  DT.97793550  DT.100733487 
    DT.100718609  DT.95308121  DT.100059444  DT.91760524  DT.121222801  DT.100052368  DT.100828399  DT.100828388 
    DT.100828393  DT.100828398  DT.95161252  DT.121222806  DT.121222869  DT.121222894  DT.91718899  DT.91939181 

    Selected AceView cDNA sequences (see all 673):

    CD365069 AA147060 BX481980 BM806566 AA043443 AW117591 CB155297 BG942523 
    AW044621 AA504449 BE350727 AU131030 AA349623 AI445018 AI141488 AU118274 
    BU508702 AW662798 BU630322 AA927888 BE670241 W95144 AW236691 BI767920 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for EIF3A (see all 8)    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11a · 11b ^ 12a · 12b ^ 13 ^ 14 ^ 15a · 15b · 15c ^ 16 ^ 17 ^ 18 ^ 19a · 19b ^ 20 ^ 21 ^
    SP1:                                                              -                                                                                             
    SP2:                                                                                                                                                            
    SP3:                                                                                                                                                            
    SP4:                                                              -                                                                                             
    SP5:                                                                                                                                                            

    ExUns: 22a · 22b ^ 23 ^ 24
    SP1:                        
    SP2:                        
    SP3:                        
    SP4:                        
    SP5:                        


    ECgene alternative splicing isoforms for EIF3A

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    EIF3A expression in normal human tissues (normalized intensities)      EIF3A embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CCTTTCAAGC
    EIF3A Expression
    About this image


    EIF3A expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 21) fully expand
     
     Brain (Nervous System)    fully expand to see all 4 entries
             Cerebral Cortex
     
     Ovary (Reproductive System)    fully expand to see all 2 entries
             Ovarian Mesenchymal Stroma Cells Ovary Interstitium
             Oviduct
     
     Testis (Reproductive System)
             Leydig Cells Testis Interstitium
     
     Liver (Hepatobiliary System)
             Hepatocytes Liver Lobule
     
     Limb (Muscoskeletal System)
             Limb Bud
    EIF3A Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    EIF3A Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.523299
        Custom PCR Arrays for EIF3A
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    OriGene qSTAR qPCR primer pairs in human, mouse for EIF3A
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of eukaryotes.

    Orthologs for EIF3A gene from Selected species (see all 28)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Eif3a1 , 5 eukaryotic translation initiation factor 3, subunit more1, 5 88.51(n)1
    96.04(a)1
      19 (56.52 cM)5
    136691  NM_010123.31  NP_034253.31 
     607611165 
    chicken
    (Gallus gallus)
    Aves EIF3A1 eukaryotic translation initiation factor 3, subunit more 75.8(n)
    83.89(a)
      423927  XM_421787.4  XP_421787.3 
    lizard
    (Anolis carolinensis)
    Reptilia EIF3A6
    eukaryotic translation initiation factor 3, subuni...
    79(a)
    1 ↔ 1
    GL343399.1(424628-452807)
    African clawed frog
    (Xenopus laevis)
    Amphibia MGC688482 Eukaryotic translation initiation factor 3 subunit more 76.71(n)    BC043785.1 
    zebrafish
    (Danio rerio)
    Actinopterygii wufi15c032 wufi15c03 76.48(n)   327515  BC059196.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta eIF3-S101 eIF3-S10 54.05(n)
    51.9(a)
      40563  NM_141213.4  NP_649470.2 
    worm
    (Caenorhabditis elegans)
    Secernentea egl-451 egl-45 51.66(n)
    41.99(a)
      176094  NM_066297.4  NP_498698.1 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes RPG1(YBR079C)4
    RPG11
    eIF3a subunit of the core complex of translation initiation more4
    RPG11
    44.05(n)1
    30.11(a)1
      2(398277-395383)4
    8523711, 4  NP_009635.11, 4 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons EIF3A1 EIF3A 49.8(n)
    40.26(a)
      826746  NM_117213.3  NP_192881.1 
    rice
    (Oryza sativa)
    Liliopsida Os.280762 Oryza sativa (japonica cultivar-group) cDNA clone0 more 67.93(n)    AK106560.1 


    ENSEMBL Gene Tree for EIF3A (if available)
    TreeFam Gene Tree for EIF3A (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for EIF3A gene
    1 SIMAP similar gene for EIF3A using alignment to 9 protein entries:     EIF3A_HUMAN (see all proteins):
    eIF3a

    EIF3A for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for EIF3A
    PGOHUM00000238636


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for EIF3A (see all 1137)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 10 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs588688251,2
    C--114442130(+) AAAAA-/AA/AAA
            
    GCTAG
    1 -- int11NA 2
    rs559674321,2
    C--114443294(+) AAAAA-/A/AA  
            
    GCTTT
    1 -- int11NA 2
    rs598465491,2
    C--114461399(+) TTTTG-/TTTTG/T
    TTTGTTTTG
    AGACA
    1 -- int11NA 2
    rs2018114471,2
    C--120794480(+) CAAGT-/AAAAAA 1 -- ds50010--------
    rs5788531,2
    C,F,H--120794673(-) GTGTTG/TACTTC 1 -- ut31 ese37Minor allele frequency- T:0.00EA NA NS 456
    rs1896399901,2
    --120795094(+) AGGTAC/TGTATC 1 -- ut310--------
    rs561958231,2
    C--120795168(+) TAACAA/GAACCT 1 -- ut310--------
    rs1821163731,2
    --120795201(+) AGATAC/TTTCAA 1 -- ut310--------
    rs710165291,2
    C--120795211(-) TTTTT-/TGATTT 1 -- ut311Minor allele frequency- T:0.00NA 2
    rs1876552891,2
    C--120795233(+) TCTATA/TCCAAG 1 -- ut310--------

    HapMap Linkage Disequilibrium report for EIF3A (120794356 - 120840334 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for EIF3A:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv990531CNV Deletion20482838
    nsv825582CNV Gain20364138

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing EIF3A
    DNA2.0 Custom Variant and Variant Library Synthesis for EIF3A

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 602039    OMIM disorders: --

    Selected diseases for EIF3A (see all 25):    About MalaCards
    noma    bardet-biedl syndrome    dermatomyositis    hepatitis c
    hepatitis c virus    nasopharyngitis    ataxia    hepatitis
    tonsillitis    lung cancer    breast cancer    schizophrenia
    pancreatic cancer    ovarian cancer    pancreatitis    alzheimer's disease
    hiv-1    melanoma    multiple myeloma    thyroiditis

    1 disease from the University of Copenhagen DISEASES database for EIF3A:
    Breast cancer

    EIF3A for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:
    The International Symposium on Pneumococci and Pneumococcal Diseases (ISPPD) 9 - 13 March 2014
    Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015

    7 Novoseek inferred disease relationships for EIF3A gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    mammary tumor 46.8 1 11457827 (1)
    cancer lung 0 1 11484932 (1)
    breast cancer 0 4 19444644 (1), 1973827 (1), 1972345 (1), 7909494 (1)
    tumors 0 8 7728765 (3), 11169732 (2), 8094034 (1), 16829125 (1) (see all 5)
    carcinoma 0 2 1973590 (2)
    hepatitis c 0 1 16322461 (1)
    cancer 0 3 18381585 (1), 16829125 (1), 15221960 (1)

    Genetic Association Database (GAD): EIF3A
    Human Genome Epidemiology (HuGE) Navigator: EIF3A (3 documents)

    Export disorders for EIF3A gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for EIF3A gene, integrated from 10 sources (see all 197):
    (articles sorted by number of sources associating them with EIF3A)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Identification of cDNA clones for the large subunit of eukaryotic translation initiation factor 3. Comparison of homologues from human, Nicotiana tabacum, Caenorhabditis elegans, and Saccharomyces cerevisiae. (PubMed id 9054404)1, 2, 3 Johnson K.R.... Zhu Y. (J. Biol. Chem. 1997)
    2. Prediction of the coding sequences of unidentified human genes. IV. The coding sequences of 40 new genes (KIAA0121-KIAA0160) deduced by analysis of cDNA clones from human cell line KG-1. (PubMed id 8590280)1, 2, 3 Nagase T.... Nomura N. (DNA Res. 1995)
    3. Characterization of eIF3k: a newly discovered subunit of mammalian translation initiation factor eIF3. (PubMed id 14519125)1, 2, 9 Mayeur G.L.... Hershey J.W.B. (Eur. J. Biochem. 2003)
    4. Structural characterization of the human eukaryotic initiation factor 3 protein complex by mass spectrometry. (PubMed id 17322308)1, 2, 9 Damoc E.... Leary J.A. (Mol. Cell. Proteomics 2007)
    5. The human p167 gene encodes a unique structural protein that contains centrosomin A homology and associates with a multicomponent complex. (PubMed id 9150439)1, 2, 9 Scholler J.K. and Kanner S.B. (DNA Cell Biol. 1997)
    6. Reconstitution reveals the functional core of mammalian eIF3. (PubMed id 17581632)1, 2, 9 Masutani M.... Imataka H. (EMBO J. 2007)
    7. Molecular interaction between human tumor marker protein p150, the largest subunit of eIF3, and intermediate filament protein K7. (PubMed id 11169732)1, 2, 9 Lin L.... Burger M.M. (J. Cell. Biochem. 2001)
    8. Mass spectrometry reveals modularity and a complete subunit interaction map of the eukaryotic translation factor eIF3. (PubMed id 18599441)1, 2 Zhou M.... Robinson C.V. (Proc. Natl. Acad. Sci. U.S.A. 2008)
    9. A scan of chromosome 10 identifies a novel locus showing strong association with late-onset Alzheimer disease. (PubMed id 16385451)1, 4 Grupe A....Goate A. (Am. J. Hum. Genet. 2006)
    10. Changes in ribosomal binding activity of eIF3 correlate with increased translation rates during activation of T lymphocytes. (PubMed id 15946946)1, 9 Miyamoto S....Hershey J.W. (J. Biol. Chem. 2005)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 8661 HGNC: 3271 AceView: EIF3S10 Ensembl:ENSG00000107581 euGenes: HUgn8661
    ECgene: EIF3A Kegg: 8661 H-InvDB: EIF3A

    (According to HUGE)
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    HUGE: KIAA0139

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for EIF3A Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for EIF3A Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for EIF3A gene:
    Search GeneIP for patents involving EIF3A

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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