Aliases for EIF3A Gene
- Eukaryotic Translation Initiation Factor 3 Subunit A 2 3 5
- Eukaryotic Translation Initiation Factor 3, Subunit 10 Theta, 150/170kDa 2 3
- Eukaryotic Translation Initiation Factor 3 Subunit 10 3 4
- EIF-3-Theta 3 4
- EIF3 P167 3 4
- EIF3 P180 3 4
- EIF3 P185 3 4
- EIF3S10 3 4
- Eukaryotic Translation Initiation Factor 3, Subunit 10 (Theta, 150/170kD) 3
- Eukaryotic Translation Initiation Factor 3, Subunit 10 (Theta, 170kD) 3
- Eukaryotic Translation Initiation Factor 3, Subunit 10, 170kD 3
- Eukaryotic Translation Initiation Factor 3, Subunit A 2
- Cytoplasmic Protein P167 3
External Ids for EIF3A Gene
Previous HGNC Symbols for EIF3A Gene
Previous GeneCards Identifiers for EIF3A Gene
GeneCards Summary for EIF3A Gene
EIF3A (Eukaryotic Translation Initiation Factor 3 Subunit A) is a Protein Coding gene. Diseases associated with EIF3A include Cribriform Carcinoma. Among its related pathways are Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S and Apoptotic Pathways in Synovial Fibroblasts. GO annotations related to this gene include poly(A) RNA binding and translation initiation factor activity.
UniProtKB/Swiss-Prot for EIF3A Gene
RNA-binding component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis (PubMed:17581632, PubMed:25849773). The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation (PubMed:17581632, PubMed:11169732). The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, including cell cycling, differentiation and apoptosis, and uses different modes of RNA stem-loop binding to exert either translational activation or repression (PubMed:25849773, PubMed:27462815).
(Microbial infection) Essential for the initiation of translation on type-1 viral ribosomal entry sites (IRESs), like for HCV, PV, EV71 or BEV translation (PubMed:23766293, PubMed:24357634).
(Microbial infection) In case of FCV infection, plays a role in the ribosomal termination-reinitiation event leading to the translation of VP2 (PubMed:18056426).