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EIF2S3 Gene

protein-coding GIFtS: 69
GCID: GC0XP024072

Eukaryotic Translation Initiation Factor 2, Subunit 3 Gamma,...

(Previous names: eukaryotic translation initiation factor 2, subunit 3 (gamma,...)
(Previous symbol: EIF2G)

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(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, ¹⁰fRNAdb, ¹²H-InvDB, ¹³NCBI, ¹⁴NONCODE, and/or ¹⁵RNAdb)
About This Section

Aliases
Eukaryotic Translation Initiation Factor 2, Subunit 3 Gamma, 52kDa¹ ²		Eukaryotic Translation Initiation Factor 2, Subunit 3 (Gamma, 52kD)¹
EIF2G¹ ² ³ ⁵		EIF2²
Eukaryotic Translation Initiation Factor 2G¹ ²		EIF2gamma²
Eukaryotic Translation Initiation Factor 2 Subunit Gamma X² ³		eIF-2gA²
eIF-2gX² ³		Eukaryotic Translation Initiation Factor 2 Subunit 3²
EIF-2-Gamma X² ³

External Ids:	HGNC: 3267¹	Entrez Gene: 1968²	Ensembl: ENSG00000130741⁷	OMIM: 300161⁵	UniProtKB: P41091³

Export aliases for EIF2S3 gene to outside databases

Previous GC identifers: GC0XP022888 GC0XP022719 GC0XP023275 GC0XP023434 GC0XP023832 GC0XP023982 GC0XP021816

(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for EIF2S3 Gene:

The protein encoded by this gene is the largest subunit of a heterotrimeric GTP-binding protein involved in the

recruitment of methionyl-tRNA(i) to the 40 S ribosomal subunit. (provided by RefSeq, Jan 2010)

GeneCards Summary for EIF2S3 Gene:

EIF2S3 (eukaryotic translation initiation factor 2, subunit 3 gamma, 52kDa) is a protein-coding gene. GO annotations related to this gene include GTP binding and translation initiation factor activity. An important paralog of this gene is LOC255308.

UniProtKB/Swiss-Prot: IF2G_HUMAN, P41091

Function: eIF-2 functions in the early steps of protein synthesis by forming a ternary complex with GTP and

initiator tRNA. This complex binds to a 40S ribosomal subunit, followed by mRNA binding to form a 43S

preinitiation complex. Junction of the 60S ribosomal subunit to form the 80S initiation complex is preceded by

hydrolysis of the GTP bound to eIF-2 and release of an eIF-2-GDP binary complex. In order for eIF-2 to recycle

and catalyze another round of initiation, the GDP bound to eIF-2 must exchange with GTP by way of a reaction

catalyzed by eIF-2B

Gene Wiki entry for EIF2S3 Gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence at NCBI GenBank:

NC_000023.10 NC_018934.2 NT_167197.2

Regulatory elements:

Regulatory transcription factor binding sites in the EIF2S3 gene promoter:
Max1 SREBP-1c Tal-1beta SREBP-1b POU2F1 SREBP-1a POU2F1a Cart-1 Sox9 ITF-2
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: EIF2S3 promoter sequence

Search Chromatin IP Primers for EIF2S3

Epigenetics:

DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat EIF2S3

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: Xp22.2-p22.1 Ensembl cytogenetic band: Xp22.11 HGNC cytogenetic band: Xp22.2-p22.1

EIF2S3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
EIF2S3 gene location

GeneLoc information about chromosome X GeneLoc Exon Structure

GeneLoc location for GC0XP024072: view genomic region (about GC identifiers)

Start:	24,072,833 bp from pter	End:	24,096,927 bp from pter
Size:	24,095 bases	Orientation:	plus strand

(According to ¹UniProtKB, HORDE, ²neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, antibodies-online, and/or GeneTex,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
About This Section

UniProtKB/Swiss-Prot: IF2G_HUMAN, P41091 (See protein sequence)

Recommended Name: Eukaryotic translation initiation factor 2 subunit 3

Size: 472 amino acids; 51109 Da

Subunit: Heterotrimer composed of an alpha, a beta and a gamma chain

Secondary accessions: B5BTZ4

Explore the universe of human proteins at neXtProt for EIF2S3: NX_P41091

Explore proteomics data for EIF2S3 at MOPED

Post-translational modifications:

Ubiquitination² at Lys27, Lys59, Lys90, Lys121, Lys196, Lys275, Lys289, Lys342

Modification sites at PhosphoSitePlus

See EIF2S3 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

REFSEQ proteins: NP_001406.1

ENSEMBL proteins:

ENSP00000253039 ENSP00000391383

Reactome Protein details: P41091

EIF2S3 Human Recombinant Protein Products:

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	antibodies-online proteins for EIF2S3 (8 products)
	antibodies-online peptides for EIF2S3

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	antibodies-online kits for EIF2S3 (12 products)

(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GenesLikeMe)
About This Section

Selected InterPro protein domains (see all 6):

IPR027417 P-loop_NTPase

IPR009001 Transl_elong_EF1A/Init_IF2_C

IPR000795 EF_GTP-bd_dom

IPR004161 Transl_elong_EFTu/EF1A_2

IPR015256 TIF2_gsu_C

Graphical View of Domain Structure for InterPro Entry P41091

ProtoNet protein and cluster: P41091

UniProtKB/Swiss-Prot: IF2G_HUMAN, P41091

Similarity: Belongs to the GTP-binding elongation factor family. EIF2G subfamily

Find genes that share domains with EIF2S3 About GenesLikeMe

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene, Sets of similar genes according to GenesLikeMe)
About This Section

Molecular Function:

UniProtKB/Swiss-Prot Summary: IF2G_HUMAN, P41091

Function: eIF-2 functions in the early steps of protein synthesis by forming a ternary complex with GTP and

initiator tRNA. This complex binds to a 40S ribosomal subunit, followed by mRNA binding to form a 43S

preinitiation complex. Junction of the 60S ribosomal subunit to form the 80S initiation complex is preceded by

hydrolysis of the GTP bound to eIF-2 and release of an eIF-2-GDP binary complex. In order for eIF-2 to recycle

and catalyze another round of initiation, the GDP bound to eIF-2 must exchange with GTP by way of a reaction

catalyzed by eIF-2B

Genatlas biochemistry entry for EIF2S3:

eukaryotic translocation initiation factor 2 gamma,escaping X-inactivation

Gene Ontology (GO): 5 molecular function terms: About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0003743	translation initiation factor activity	IDA	10900014
GO:0003924	GTPase activity	IEA	--
GO:0005515	protein binding	IPI	16288713
GO:0005525	GTP binding	IEA	--
GO:0008135	translation factor activity, nucleic acid binding	IDA	10900014

Find genes that share ontologies with EIF2S3 About GenesLikeMe

Phenotypes:
4 GenomeRNAi human phenotypes for EIF2S3:

Decreased viability of wild-ty

G0/1 arrest

Increased G1 DNA content

Increased gamma-H2AX phosphory

Animal Models:

genOway: Develop your customized and physiologically relevant rodent model for EIF2S3

miRNA Products:		miRTarBase miRNAs that target EIF2S3: hsa-mir-98-5p (MIRT027622), hsa-mir-92a-3p (MIRT049409), hsa-mir-30c-5p (MIRT047883), hsa-mir-24-3p (MIRT030483), hsa-mir-331-3p (MIRT043305), hsa-mir-196a-5p (MIRT048212), hsa-mir-7-5p (MIRT025848)

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		Selected qRT-PCR Assays for microRNAs that regulate EIF2S3 (see all 24):
		hsa-miR-607 hsa-miR-137 hsa-miR-548v hsa-miR-221 hsa-miR-132 hsa-miR-373* hsa-miR-3171 hsa-miR-374a*

		SwitchGear 3'UTR luciferase reporter plasmid: EIF2S3 3' UTR sequence

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Gene Editing
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In Situ Assay
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Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for EIF2S3

(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene, Sets of similar genes according to GenesLikeMe)
About This Section

Subcellular locations from COMPARTMENTS:

Compartment	Confidence
cytosol	4
nucleus	2
peroxisome	1

About this image

Gene Ontology (GO): 2 cellular component terms: About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005829	cytosol	TAS	--
GO:0070062	extracellular vesicular exosome	IDA	--

Find genes that share ontologies with EIF2S3 About GenesLikeMe

(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GenesLikeMe, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene, Sets of similar genes according to GenesLikeMe)
About This Section

SuperPaths for EIF2S3 About (see all 9)

See pathways by source

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SuperPath

Contained pathways About

Translation Insulin regulation of translation

	Translation Insulin regulation of translation	0.59			Recycling of eIF2-GDP	0.00
	Translation Regulation of EIF2 activity	0.47

Influenza Viral RNA Transcription and Replication

L13a-mediated translational silencing of Ceruloplasmin expression	0.94	Cap-dependent Translation Initiation	0.89
GTP hydrolysis and joining of the 60S ribosomal subunit	0.93	Translation	0.82
Eukaryotic Translation Initiation	0.89

Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S

	Formation of the ternary complex, and subsequently, the 43S complex	0.91			Translation initiation complex formation	0.91
	Ribosomal scanning and start codon recognition	0.91			Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S	0.90

Nanog in Mammalian ESC Pluripotency

GSK3 Signaling

0.61

Apoptotic Pathways in Synovial Fibroblasts

eIF2 Pathway

0.60

Find genes that share SuperPaths with EIF2S3 About GenesLikeMe

Pathways by source See SuperPaths
Show all pathways

2 Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for EIF2S3

	GSK3 Signaling
	eIF2 Pathway

2 GeneGo (Thomson Reuters) Pathways for EIF2S3

	Translation Insulin regulation of translation
	Translation Regulation of EIF2 activity

1 BioSystems Pathway for EIF2S3

Translation Factors

Selected Reactome Pathways for EIF2S3 (see all 6)

	Formation of the ternary complex, and subsequently, the 43S complex
	L13a-mediated translational silencing of Ceruloplasmin expression
	GTP hydrolysis and joining of the 60S ribosomal subunit
	Ribosomal scanning and start codon recognition
	Translation initiation complex formation

1 Kegg Pathway (Kegg details for EIF2S3):

RNA transport

Custom Pathway & Disease-focused RT² Profiler PCR Arrays for EIF2S3
Interactions:

GeneGlobe Interaction Network for EIF2S3

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

Selected Interacting proteins for EIF2S3 (P41091^{1, 2, 3} ENSP00000253039⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 1006)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
HIST1H4A	P62805³	I2D: score=1
HIST1H4B	P62805³	I2D: score=1
HIST1H4C	P62805³	I2D: score=1
HIST1H4D	P62805³	I2D: score=1
HIST1H4E	P62805³	I2D: score=1

About this table

Gene Ontology (GO): 5 biological process terms: About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006184	GTP catabolic process	TAS	8106381
GO:0006412	translation	TAS	--
GO:0006413	translational initiation	TAS	--
GO:0010467	gene expression	TAS	--
GO:0044267	cellular protein metabolic process	TAS	--

Find genes that share ontologies with EIF2S3 About GenesLikeMe

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, Sets of similar genes according to GenesLikeMe)
About This Section

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse compounds at ApexBio

Browse Tocris compounds for EIF2S3 (IF2G)

1 HMDB Compound for EIF2S3 About this table

Compound	Synonyms	CAS #	PubMed Ids
Guanosine triphosphate	5'-GTP (see all 10)	86-01-1	--

1 DrugBank Compound for EIF2S3 About this table

Compound	Synonyms	CAS #	Type	Actions	PubMed Ids
Guanosine-5'-Diphosphate	--	146-91-8	target	--	17139284 17016423 10592235

3 Novoseek inferred chemical compound relationships for EIF2S3 gene About this table

Compound	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
gtp	69.2	37	2111815 (7), 16246727 (4), 1698457 (3), 2383020 (2) (see all 11)
gdp	64.3	8	8049218 (2), 1772426 (1), 1772451 (1)
atp	0	14	2111815 (10)

Find genes that share compounds with EIF2S3 About GenesLikeMe

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
About This Section

REFSEQ mRNAs for EIF2S3 gene:

NM_001415.3

Unigene Cluster for EIF2S3:

Eukaryotic translation initiation factor 2, subunit 3 gamma, 52kDa

Hs.539684 [show with all ESTs]

Unigene Representative Sequence: NM_001415

5 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000253039(uc004dbc.3) ENST00000487075 ENST00000423068 ENST00000460032

ENST00000457332

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		Selected qRT-PCR Assays for microRNAs that regulate EIF2S3 (see all 24):
		hsa-miR-607 hsa-miR-137 hsa-miR-548v hsa-miR-221 hsa-miR-132 hsa-miR-373* hsa-miR-3171 hsa-miR-374a*

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Additional mRNA sequence:

AB451230.1 AB451353.1 AF274932.1 AK222577.1 AK290397.1 AK312247.1 BC011945.1 BC019906.1

L19161.1

20 DOTS entries:

DT.95237798 DT.447700 DT.100030262 DT.91731366 DT.92458463 DT.100701111 DT.97787287 DT.91658298

DT.92458454 DT.121175094 DT.40111550 DT.92458482 DT.121311767 DT.121311768 DT.121311760 DT.91684318

DT.92458446 DT.95338524 DT.97855328 DT.97855329

Selected AceView cDNA sequences (see all 438):

BM751119 BQ441768 BM821227 CF136987 BM464567 BU615962 AU139597 BI258640

BM459962 AW514785 BM453923 N53698 BC011945 BP354235 AA460651 BG574758

AI499262 BQ082297 AU125883 AU131880 AA694530 AA025869 AI914895 N46476

GeneLoc Exon Structure

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GenesLikeMe, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE ¹MOPED, ²PaxDb, and ³MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

EIF2S3 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>^2/3
CGAP TAG: AGGAACACAA

About this image

EIF2S3 expression in embryonic tissues and stem cells About this table

Data from LifeMap, the Embryonic Development and Stem Cells Database
selected tissues (see all 5) fully expand


Limb (Muscoskeletal System) fully expand to see all 5 entries
Interzone Cells Stylopod Synovial Joint
Zeugopod

Gut Tube (Gastrointestinal Tract)
Foregut

Cartilage (Muscoskeletal System)
Interzone Cells Stylopod Synovial Joint

Ovary (Reproductive System)

Uterus (Reproductive System)

EIF2S3 Protein expression data from MOPED¹, PaxDb² and MaxQB³:

About this image

EIF2S3 Protein Expression

SOURCE GeneReport for Unigene cluster: Hs.539684

Custom PCR Arrays for EIF2S3

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In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for EIF2S3

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of eukaryotes.

Orthologs for EIF2S3 gene from Selected species (see all 21) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
mouse (Mus musculus)	Mammalia	Eif2s3x^{1 , 5}	eukaryotic translation initiation factor 2, subunit more^{1, 5}	90.89(n)¹ 99.58(a)¹		X (41.52 cM)⁵ 26905¹ NM_012010.3¹ NP_036140.1¹ 94188707⁵
chicken (Gallus gallus)	Aves	EIF2S3¹	eukaryotic translation initiation factor 2, subunit more	84.25(n) 98.73(a)		418597 NM_001006260.1 NP_001006260.1
lizard (Anolis carolinensis)	Reptilia	--	Uncharacterized protein	97(a)	1 → many	3(125777817-125792105)
African clawed frog (Xenopus laevis)	Amphibia	eif2s3-prov²	eukaryotic translation initiation factor 2, subunit more	81.58(n)		BC043966.1
zebrafish (Danio rerio)	Actinopterygii	Dr.26653²	Danio rerio eukaryotic translation initiation factor more	80.19(n)		BC055248.1
fruit fly (Drosophila melanogaster)	Insecta	eIF-2gamma¹	Eukaryotic initiation factor 2gamma	67.31(n) 81.45(a)		41843 NM_169629.2 NP_731993.1
worm (Caenorhabditis elegans)	Secernentea	Y39G10AR.8³ CELE_Y39G10AR.8¹	CELE_Y39G10AR.8¹	75(a)³ 65.2(n)¹ 75(a)¹		I(2313312-2315761)³ 171792¹ NM_058559.6¹ NP_490960.1¹
baker's yeast (Saccharomyces cerevisiae)	Saccharomycetes	GCD11(YER025W)⁴	Gamma subunit of the translation initiation factor more	--		5(205251-206834) 856746 NP_010942.1
thale cress (Arabidopsis thaliana)	eudicotyledons	EIF2 GAMMA¹	EIF2 GAMMA	64.9(n) 72.35(a)		839238 NM_100298.2 NP_171913.1
rice (Oryza sativa)	Liliopsida	Os12g0607100¹	Os12g0607100	66.59(n) 74.34(a)		4352748 NM_001073765.1 NP_001067233.1

ENSEMBL Gene Tree for EIF2S3 (if available)
TreeFam Gene Tree for EIF2S3 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68,Sets of similar genes according to GenesLikeMe)
About This Section

Paralogs for EIF2S3 gene

LOC255308²

1 SIMAP similar gene for EIF2S3 using alignment to 2 protein entries: IF2G_HUMAN (see all proteins):

EIF2S3L

Find genes that share paralogs with EIF2S3 About GenesLikeMe

2 Pseudogenes.org Pseudogenes for EIF2S3
PGOHUM00000244588 PGOHUM00000245661

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, ⁴UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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SNP ID	Valid	Clinical significance	Chr X pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs12557785^1,2	C,A,H	--	23986179(+)	`ggaatC/Gaaccc`	1	--	us2k¹		0	--	--	--	--
rs192788676^1,2		--	23986582(+)	`ATGCAC/TCCCTG`	1	--	us2k¹		0	--	--	--	--
rs183860286^1,2		--	23986719(+)	`TATATA/TTTGAG`	1	--	us2k¹		0	--	--	--	--
rs188184471^1,2		--	23986850(+)	`CAGGCA/GCCCGC`	1	--	us2k¹		0	--	--	--	--
rs34116629^1,2	C	--	23986872(+)	`TTTTT-/TGTATT`	1	--	us2k¹		0	--	--	--	--
rs145518450^1,2	C	--	23986980(+)	`GTGCTA/GGGATT`	1	--	us2k¹		0	--	--	--	--
rs181301306^1,2		--	23987085(+)	`TTCTCA/GGTATT`	1	--	us2k¹		0	--	--	--	--
rs148421431^1,2		--	23987244(+)	`GAAAAA/GCAAAT`	1	--	us2k¹		0	--	--	--	--
rs185660497^1,2		--	23987251(+)	`AAATCA/GCTCAA`	1	--	us2k¹		0	--	--	--	--
rs74361699^1,2	C	--	23987284(+)	`GTGGGC/TTAAGG`	1	--	us2k¹		0	--	--	--	--

HapMap Linkage Disequilibrium report for EIF2S3 (24072833 - 24096927 bp)

Structural Variations
Database of Genomic Variants (DGV) 2 variations for EIF2S3: About this table

Variant ID	Type	Subtype	PubMed ID
esv2740010	CNV	Deletion	23290073
nsv524256	CNV	Gain	19592680

Human Gene Mutation Database (HGMD): EIF2S3
Locus Specific Mutation Databases (LSDB): EIF2S3

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB, Sets of similar genes according to GenesLikeMe)
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OMIM gene information: 300161 OMIM disorders: --

Find genes that share disorders with EIF2S3 About GenesLikeMe

Genetic Association Database (GAD): EIF2S3
Human Genome Epidemiology (HuGE) Navigator: EIF2S3 (1 document)

Export disorders for EIF2S3 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
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PubMed articles for EIF2S3 gene, integrated from 10 sources (see all 87):
(articles sorted by number of sources associating them with EIF2S3)

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Translation initiation factor eIF-2. Cloning and expression of the human cDNA encoding the gamma-subunit. (PubMed id 8106381)^{1, 2, 3} Gaspar N.J....Merrick W.C. (J. Biol. Chem. 1994)
Association of the X-chromosomal genes TIMP1 and IL9R with rheumatoid arthritis. (PubMed id 19723899)^{1, 4} Burkhardt J....Ahnert P. (J. Rheumatol. 2009)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S.... Malek J. (Genome Res. 2004)
Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides. (PubMed id 12665801)^{1, 2} Gevaert K.... Vandekerckhove J. (Nat. Biotechnol. 2003)
Characterization of genes encoding translation initiation factor eIF- 2gamma in mouse and human: sex chromosome localization, escape from X- inactivation and evolution. (PubMed id 9736774)^{1, 3} Ehrmann I.E.... Scott D.M. (Hum. Mol. Genet. 1998)
Interlaboratory reproducibility of large-scale human protein-complex analysis by standardized AP-MS. (PubMed id 23455922)¹ Varjosalo M....Superti-Furga G. (Nat. Methods 2013)
The protein interaction landscape of the human CMGC kinase group. (PubMed id 23602568)¹ Varjosalo M....Gstaiger M. (Cell Rep 2013)
A census of human soluble protein complexes. (PubMed id 22939629)¹ Havugimana P.C....Emili A. (Cell 2012)
A high-throughput approach for measuring temporal changes in the interactome. (PubMed id 22863883)¹ Kristensen A.R....Foster L.J. (Nat. Methods 2012)
Targeted ubiquitination and degradation of G-protein-coupled receptor kinase 5 by the DDB1-CUL4 ubiquitin ligase complex. (PubMed id 22952844)¹ Wu Z....Ma L. (PLoS ONE 2012)

(in PubMed, OMIM, and NCBI Bookshelf)
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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 1968	HGNC: 3267	AceView: EIF2S3	Ensembl:ENSG00000130741	euGenes: HUgn1968
ECgene: EIF2S3	Kegg: 1968	H-InvDB: EIF2S3

(According to HUGE)
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(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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Name	Description
PharmGKB entry for EIF2S3	Pharmacogenomics, SNPs, Pathways

Intellectual Property for EIF2S3 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

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Patent Information for EIF2S3 gene:
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GeneCards and IP:
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EIF2S3 Gene

Eukaryotic Translation Initiation Factor 2, Subunit 3 Gamma,...

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EIF2S3 Gene

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