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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

EIF2S3 Gene

protein-coding GIFtS: 64
GCID: GC0XP024072

eukaryotic translation initiation factor 2, subunit 3 gamma,...

(Previous names: eukaryotic translation initiation factor 2, subunit 3 (gamma,...)
(Previous symbol: EIF2G)

Explore 11 diseases affiliated with
EIF2S3 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Eukaryotic Translation Initiation Factor 2, Subunit 3 Gamma, 52kDa¹ ²		EIF-2-Gamma X² ³
EIF2G¹ ² ³ ⁵		Eukaryotic Translation Initiation Factor 2, Subunit 3 (Gamma, 52kD)¹
EIF2¹ ²		EIF-2gA¹
EIF2gamma¹ ²		Eukaryotic Translation Initiation Factor 2 Subunit 3²
Eukaryotic Translation Initiation Factor 2 Subunit Gamma X² ³		Eukaryotic Translation Initiation Factor 2G²
EIF-2gX¹

External Ids:	HGNC: 3267¹	Entrez Gene: 1968²	Ensembl: ENSG00000130741⁷	OMIM: 300161⁵	UniProtKB: P41091³

Export aliases for EIF2S3 gene to outside databases

Previous GC identifers: GC0XP022888 GC0XP022719 GC0XP023275 GC0XP023434 GC0XP023832 GC0XP023982 GC0XP021816

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for EIF2S3:

The protein encoded by this gene is the largest subunit of a heterotrimeric GTP-binding protein involved in the

recruitment of methionyl-tRNA(i) to the 40 S ribosomal subunit. (provided by RefSeq, Jan 2010)

UniProtKB/Swiss-Prot: IF2G_HUMAN, P41091

Function: eIF-2 functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator

tRNA. This complex binds to a 40S ribosomal subunit, followed by mRNA binding to form a 43S preinitiation complex.

Junction of the 60S ribosomal subunit to form the 80S initiation complex is preceded by hydrolysis of the GTP bound to

eIF-2 and release of an eIF-2-GDP binary complex. In order for eIF-2 to recycle and catalyze another round of

initiation, the GDP bound to eIF-2 must exchange with GTP by way of a reaction catalyzed by eIF-2B

Gene Wiki entry for EIF2S3

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000023.10 NC_018934.1 NT_167197.1

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the EIF2S3 gene promoter:
Max1 SREBP-1c Tal-1beta SREBP-1b POU2F1 SREBP-1a POU2F1a Cart-1 Sox9 ITF-2
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: EIF2S3 promoter sequence

Search SABiosciences Chromatin IP Primers for EIF2S3

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat EIF2S3

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: Xp22.2-p22.1 Ensembl cytogenetic band: Xp22.11 HGNC cytogenetic band: Xp22.2-p22.1

EIF2S3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
EIF2S3 gene location

GeneLoc information about chromosome X GeneLoc Exon Structure

GeneLoc location for GC0XP024072: view genomic region (about GC identifiers)

Start:	24,072,833 bp from pter	End:	24,096,927 bp from pter
Size:	24,095 bases	Orientation:	plus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: IF2G_HUMAN, P41091 (See protein sequence)

Recommended Name: Eukaryotic translation initiation factor 2 subunit 3

Size: 472 amino acids; 51109 Da

Subunit: Heterotrimer composed of an alpha, a beta and a gamma chain

Secondary accessions: B5BTZ4

Explore the universe of human proteins at neXtProt for EIF2S3: NX_P41091

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_P41091

EIF2S3 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins: NP_001406.1

ENSEMBL proteins:

ENSP00000253039 ENSP00000391383

Reactome Protein details: P41091
Human Recombinant Protein Products:

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	Uscn Proteins for EIF2S3

Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005829	cytosol	TAS	--

EIF2S3 for ontologies About GeneDecksing

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	Uscn ELISAs and CLIAs for EIF2S3

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

EIF2S3 for domains About GeneDecksing

5 InterPro domains/families:

IPR009001 Transl_elong_EF1A/Init_IF2_C

IPR000795 EF_GTP-bd_dom

IPR004161 Transl_elong_EFTu/EF1A_2

IPR015256 TIF2_gsu_C

IPR009000 Transl_elong_init/rib_B-barrel

Graphical View of Domain Structure for InterPro Entry P41091

ProtoNet protein and cluster: P41091

UniProtKB/Swiss-Prot: IF2G_HUMAN, P41091

Similarity: Belongs to the GTP-binding elongation factor family. EIF2G subfamily

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

UniProtKB/Swiss-Prot: IF2G_HUMAN, P41091

Function: eIF-2 functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator

tRNA. This complex binds to a 40S ribosomal subunit, followed by mRNA binding to form a 43S preinitiation complex.

Junction of the 60S ribosomal subunit to form the 80S initiation complex is preceded by hydrolysis of the GTP bound to

eIF-2 and release of an eIF-2-GDP binary complex. In order for eIF-2 to recycle and catalyze another round of

initiation, the GDP bound to eIF-2 must exchange with GTP by way of a reaction catalyzed by eIF-2B

Genatlas biochemistry entry for EIF2S3:

eukaryotic translocation initiation factor 2 gamma,escaping X-inactivation

miRNA Products:		OriGene 3'-UTR Clone: EIF2S3 Browse MicroRNA Expression Plasmids
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		8/24 QIAGEN miScript miRNA Assays for microRNAs that regulate EIF2S3 (see all 24):
		hsa-miR-607 hsa-miR-137 hsa-miR-548v hsa-miR-221 hsa-miR-132 hsa-miR-373* hsa-miR-3171 hsa-miR-374a*

		SwitchGear 3'UTR luciferase reporter plasmid: EIF2S3 3' UTR sequence

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Gene Editing
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In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for EIF2S3

Gene Ontology (GO): 5 molecular function terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0003743	translation initiation factor activity	IDA	16289705
GO:0003924	GTPase activity	IEA	--
GO:0005515	protein binding	IPI	16288713
GO:0005525	GTP binding	IEA	--
GO:0008135	translation factor activity, nucleic acid binding	IDA	10900014

EIF2S3 for ontologies About GeneDecksing

4 GenomeRNAi human phenotypes for EIF2S3:

Decreased viability of wild-ty

G0/1 arrest

Increased G1 DNA content

Increased gamma-H2AX phosphory

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways - 5/10 super-pathways (see all 10) About this table

See pathways by source

Super-pathway

contained gene-specific pathways

Synthesis of PB1-F2

L13a-mediated translational silencing of Ceruloplasmin expression	0.79	Eukaryotic Translation Initiation	0.73
3' -UTR-mediated translational regulation	0.79	Cap-dependent Translation Initiation	0.73
GTP hydrolysis and joining of the 60S ribosomal subunit	0.78	Translation	0.57

Translation initiation complex formation

	Translation initiation complex formation	1.00			Ribosomal scanning and start codon recognition	0.96
	Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S	0.98			Formation of the ternary complex, and subsequently, the 43S complex	0.87

Development_CNTF receptor signaling

	Translation_Insulin regulation of translation	0.35			Translation _Regulation of EIF2 activity	0.25
	Translation Insulin regulation of translation	0.35			Translation Regulation activity of EIF2	0.25

Recycling of eIF2:GDP

Recycling of eIF2:GDP

1.00

Translation Factors

Translation Factors

1.00

Pathway sources
See GeneCards unified pathways
Show all pathways

2 EMD Millipore Pathways for EIF2S3

	Translation Insulin regulation of translation
	Translation Regulation activity of EIF2

2 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for EIF2S3

	GSK3 Signaling
	eIF2 Pathway

2 GeneGo (Thomson Reuters) Pathways for EIF2S3

	Translation Insulin regulation of translation
	Translation Regulation of EIF2 activity

1 BioSystems Pathway for EIF2S3

Translation Factors

5/13 Reactome Pathways for EIF2S3 (see all 13)

	Formation of the ternary complex, and subsequently, the 43S complex
	Translation
	GTP hydrolysis and joining of the 60S ribosomal subunit
	Eukaryotic Translation Initiation
	Ribosomal scanning and start codon recognition

1 Kegg Pathway (Kegg details for EIF2S3):

RNA transport

EIF2S3 for pathways About GeneDecksing

Interactions:

SABiosciences Gene Network Central^TM Interacting Genes and Proteins Network for EIF2S3

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

5/917 Interacting proteins for EIF2S3 (P41091^{1, 2, 3} ENSP00000253039⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 917)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
HIST1H4A	P62805³	I2D: score=1
HIST1H4B	P62805³	I2D: score=1
HIST1H4C	P62805³	I2D: score=1
HIST1H4D	P62805³	I2D: score=1
HIST1H4E	P62805³	I2D: score=1

About this table

Gene Ontology (GO): 5 biological process terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006184	GTP catabolic process	TAS	8106381
GO:0006412	translation	TAS	--
GO:0006413	translational initiation	TAS	--
GO:0010467	gene expression	TAS	--
GO:0044267	cellular protein metabolic process	TAS	--

EIF2S3 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

EIF2S3 for compounds About GeneDecksing

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for EIF2S3

1 HMDB Compound for EIF2S3 About this table

Compound	Synonyms	CAS #	PubMed Ids
Guanosine triphosphate	5'-GTP (see all 10)	86-01-1	--

1 DrugBank Compound for EIF2S3 About this table

Compound	Synonyms	CAS #	Type	Actions	PubMed Ids
Guanosine-5'-Diphosphate	--	146-91-8	target	--	17139284 17016423 10592235

3 Novoseek chemical compound relationships for EIF2S3 gene About this table

Compound	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
gtp	69.2	37	2111815 (7), 16246727 (4), 1698457 (3), 2383020 (2) (see all 11)
gdp	64.3	8	8049218 (2), 1772426 (1), 1772451 (1)
atp	0	14	2111815 (10)

Search CenterWatch for drugs/clinical trials and news about EIF2S3 / IF2G

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for EIF2S3 gene:

NM_001415.3

Unigene Cluster for EIF2S3:

Eukaryotic translation initiation factor 2, subunit 3 gamma, 52kDa

Hs.539684 [show with all ESTs]

Unigene Representative Sequence: NM_001415

4 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000253039(uc004dbc.3) ENST00000487075 ENST00000423068 ENST00000460032

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		8/24 QIAGEN miScript miRNA Assays for microRNAs that regulate EIF2S3 (see all 24):
		hsa-miR-607 hsa-miR-137 hsa-miR-548v hsa-miR-221 hsa-miR-132 hsa-miR-373* hsa-miR-3171 hsa-miR-374a*

		SwitchGear 3'UTR luciferase reporter plasmid: EIF2S3 3' UTR sequence

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Additional cDNA sequence:

AB451230.1 AB451353.1 AF274932.1 AK222577.1 AK290397.1 AK312247.1 BC011945.1 BC019906.1

L19161.1

20 DOTS entries:

DT.95237798 DT.447700 DT.100030262 DT.91731366 DT.92458463 DT.100701111 DT.97787287 DT.91658298

DT.92458454 DT.121175094 DT.40111550 DT.92458482 DT.121311767 DT.121311768 DT.121311760 DT.91684318

DT.92458446 DT.95338524 DT.97855328 DT.97855329

24/438 AceView cDNA sequences (see all 438):

CF136987 AI697002 AI708722 BM751119 BM560059 AI914895 BI833191 CA448538

BQ441768 BM456782 AU131590 BP375953 AW009616 AI619733 BU167711 AW085039

AA077935 L19161 CB120706 BM457802 BI258640 BG758429 AA593640 BQ774753

GeneLoc Exon Structure

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

EIF2S3 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: AGGAACACAA

About this image

EIF2S3 expression in embryonic tissues and stem cells

Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

6 LifeMap In Vivo Development Anatomical Compartments/Cells

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Limb

Stylopod Synovial Joint

Interzone Cells

Cartilage

Limb

Limb

Stylopod Synovial Joint

Limb

Zeugopod

Limb

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

See EIF2S3 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for EIF2S3

SOURCE GeneReport for Unigene cluster: Hs.539684

SABiosciences Custom PCR Arrays for EIF2S3

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for EIF2S3 Browse OriGene validated miRNA SYBR primer pairs
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		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat EIF2S3

In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for EIF2S3

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the last universal common ancestor (LUCA).

Orthologs for EIF2S3 gene from 10/39 species (see all 39) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
chicken (Gallus gallus)	Aves	EIF2S3⁶	eukaryotic translation initiation factor 2, subuni...	99(a)	1 → many	1(121677562-121690591)
lizard (Anolis carolinensis)	Reptilia	-- TUFM⁶	--	97(a) 23(a)	possible ortholog possible ortholog	3(125778121-125790504) GL343287.1(396340-401505)
African clawed frog (Xenopus laevis)	Amphibia	eif2s3-prov²	eukaryotic translation initiation factor 2, subunit more	81.58(n)		BC043966.1
zebrafish (Danio rerio)	Actinopterygii	Dr.26653²	Danio rerio eukaryotic translation initiation factor more	80.19(n)		BC055248.1
fruit fly (Drosophila melanogaster)	Insecta	eIF-2gamma⁶ CG12736⁶ (see all 3)	--	80(a) 20(a) (see all 3)	1 ↔ many possible ortholog (see all 3)	3R(11083661-11089196) 2R(3396032-3397959)
worm (Caenorhabditis elegans)	Secernentea	Y39G10AR.8³	--	75(a)		I(2313312-2315761) --
baker's yeast (Saccharomyces cerevisiae)	Saccharomycetes	GCD11(YER025W)⁴ GCD11¹	Gamma subunit of the translation initiation factor more⁴ Gcd11p¹	65.39(n)¹ 74.04(a)¹		5(205251-206834)⁴ 856746^{1, 4} NP_010942.1^{1, 4}
thale cress (Arabidopsis thaliana)	eudicotyledons	AT4G18330¹	putative translation elongation factor 2EF1A / eIF-2-gamma	64.75(n) 69.84(a)		827559 NM_202838.1 NP_974567.1
rice (Oryza sativa)	Liliopsida	-- -- (see all 4)	eukaryotic translation initiation factor 2 subunit... eukaryotic translation initiation factor 2 subunit... (see all 4)	73(a) 72(a) (see all 4)	many ↔ many many ↔ many (see all 4)	12(25613822-25618647) 12(3884386-3888692)
E. coli (Escherichia coli)	Gamma proteobacteria	tufB⁶ tufA⁶	protein chain elongation factor EF-Tu (duplicate o... protein chain elongation factor EF-Tu (duplicate o...	25(a) 25(a)	possible ortholog possible ortholog	Chromosome(4173967-4175151) Chromosome(3468167-3469351)

ENSEMBL Gene Tree for EIF2S3 (if available)
TreeFam Gene Tree for EIF2S3 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for EIF2S3 gene

LOC255308²

1 SIMAP similar gene for EIF2S3 using alignment to 2 protein entries: IF2G_HUMAN (see all proteins):

EIF2S3L

EIF2S3 for paralogs About GeneDecksing

2 Pseudogenes.org Pseudogenes for EIF2S3
PGOHUM00000244588 PGOHUM00000245661

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr X pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs12557785^1,2	C,A,H	--	24071141(+)	`GGAATC/GAACCC`	1	--	us2k¹		0	--	--	--	--
rs192788676^1,2		--	24071544(+)	`ATGCAC/TCCCTG`	1	--	us2k¹		0	--	--	--	--
rs183860286^1,2		--	24071681(+)	`TATATA/TTTGAG`	1	--	us2k¹		0	--	--	--	--
rs188184471^1,2		--	24071812(+)	`CAGGCA/GCCCGC`	1	--	us2k¹		0	--	--	--	--
rs145518450^1,2		--	24071943(+)	`GTGCTA/GGGATT`	1	--	us2k¹		0	--	--	--	--
rs181301306^1,2		--	24072048(+)	`TTCTCA/GGTATT`	1	--	us2k¹		0	--	--	--	--
rs148421431^1,2		--	24072207(+)	`GAAAAA/GCAAAT`	1	--	us2k¹		0	--	--	--	--
rs185660497^1,2		--	24072214(+)	`AAATCA/GCTCAA`	1	--	us2k¹		0	--	--	--	--
rs74361699^1,2	C	--	24072247(+)	`GTGGGC/TTAAGG`	1	--	us2k¹		0	--	--	--	--
rs7061325^1,2	C,A,H	--	24072336(+)	`AAAAAC/AAAAAC`	1	--	us2k¹ tfbs³		5		NS EA NA	420

HapMap Linkage Disequilibrium report for EIF2S3 (24072833 - 24096927 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for EIF2S3: --
Human Gene Mutation Database (HGMD): EIF2S3

Locus Specific Mutation Databases (LSDB): EIF2S3

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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EIF2S3 for disorders           About GeneDecksing

OMIM gene information: 300161    OMIM disorders: --

11 diseases for EIF2S3:    About MalaCards

x inactivation intrahepatic cholangiocarcinoma rheumatoid arthritis hepatitis c

cholangiocarcinoma arthritis prostate cancer hepatitis

prostatitis immunodeficiency malaria

Human Genome Epidemiology (HuGE) Navigator: EIF2S3 (1 document)

Export disorders for EIF2S3 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
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PubMed articles for EIF2S3 gene, integrated from 9 sources (see all 82):
(articles sorted by number of sources associating them with EIF2S3)

Utopia: connect your pdf to the dynamic
world of online information

Translation initiation factor eIF-2. Cloning and expression of the human cDNA encoding the gamma-subunit. (PubMed id 8106381)^{1, 2, 3} Gaspar N.J....Merrick W.C. (1994)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides. (PubMed id 12665801)^{1, 2} Gevaert K.... Vandekerckhove J. (2003)
Characterization of genes encoding translation initiation factor eIF- 2gamma in mouse and human: sex chromosome localization, escape from X- inactivation and evolution. (PubMed id 9736774)^{1, 3} Ehrmann I.E.... Scott D.M. (1998)
A census of human soluble protein complexes. (PubMed id 22939629)¹ Havugimana P.C....Emili A. (2012)
A high-throughput approach for measuring temporal chan ges in the interactome. (PubMed id 22863883)¹ Kristensen A.R....Foster L.J. (2012)
Targeted ubiquitination and degradation of G-protein-c oupled receptor kinase 5 by the DDB1-CUL4 ubiquitin ligase complex. (PubMed id 22952844)¹ Wu Z....Ma L. (2012)
The proteomic analysis of endogenous FAT10 substrates identifies p62/SQSTM1 as a substrate of FAT10ylation. (PubMed id 22797925)¹ Aichem A....Groettrup M. (2012)
Host cell interactome of HIV-1 Rev includes RNA helica ses involved in multiple facets of virus production. (PubMed id 22174317)¹ Naji S....Gerace L. (2012)
A cohesin-RAD21 interactome. (PubMed id 22145905)¹ Panigrahi A.K....Pati D. (2012)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 1968	HGNC: 3267	AceView: EIF2S3	Ensembl:ENSG00000130741	euGenes: HUgn1968
ECgene: EIF2S3	Kegg: 1968	H-InvDB: EIF2S3

(According to HUGE)
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(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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Name	Description
PharmGKB entry for EIF2S3	Pharmacogenomics, SNPs, Pathways

Intellectual Property for EIF2S3 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

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Patent Information for EIF2S3 gene:
Search GeneIP for patents involving EIF2S3

GeneCards and IP:
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