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Aliases for EIF2S3 Gene

Aliases for EIF2S3 Gene

  • Eukaryotic Translation Initiation Factor 2 Subunit Gamma 2 3 5
  • Eukaryotic Translation Initiation Factor 2, Subunit 3 Gamma, 52kDa 2 3
  • Eukaryotic Translation Initiation Factor 2 Subunit Gamma X 3 4
  • Eukaryotic Translation Initiation Factor 2G 2 3
  • EIF-2-Gamma X 3 4
  • EIF-2gX 3 4
  • EIF2G 3 4
  • Eukaryotic Translation Initiation Factor 2, Subunit 3 (Gamma, 52kD) 2
  • EIF2gamma 3
  • EIF-2gA 3
  • EIF2 3

External Ids for EIF2S3 Gene

Previous HGNC Symbols for EIF2S3 Gene

  • EIF2G

Previous GeneCards Identifiers for EIF2S3 Gene

  • GC0XP022888
  • GC0XP022719
  • GC0XP023275
  • GC0XP023434
  • GC0XP023832
  • GC0XP023982
  • GC0XP021816

Summaries for EIF2S3 Gene

Entrez Gene Summary for EIF2S3 Gene

  • The protein encoded by this gene is the largest subunit of a heterotrimeric GTP-binding protein involved in the recruitment of methionyl-tRNA(i) to the 40 S ribosomal subunit. [provided by RefSeq, Jan 2010]

GeneCards Summary for EIF2S3 Gene

EIF2S3 (Eukaryotic Translation Initiation Factor 2 Subunit Gamma) is a Protein Coding gene. Among its related pathways are Gene Expression and Transport to the Golgi and subsequent modification. GO annotations related to this gene include GTP binding and translation initiation factor activity. An important paralog of this gene is LOC255308.

UniProtKB/Swiss-Prot for EIF2S3 Gene

  • As a subunit of eukaryotic initiation factor 2 (eIF2), involved in the early steps of protein synthesis. In the presence of GTP, eIF2 forms a ternary complex with initiator tRNA Met-tRNAi and then recruits the 40S ribosomal complex, a step that determines the rate of protein translation. This step is followed by mRNA binding to form the 43S pre-initiation complex. Junction of the 60S ribosomal subunit to form the 80S initiation complex is preceded by hydrolysis of the GTP bound to eIF2 and release of an eIF2-GDP binary complex. In order for eIF2 to recycle and catalyze another round of initiation, the GDP bound to eIF2 must exchange with GTP by way of a reaction catalyzed by eIF2B (By similarity). Along with its paralog on chromosome Y, may contribute to spermatogenesis up to the round spermatid stage (By similarity).

Gene Wiki entry for EIF2S3 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for EIF2S3 Gene

Genomics for EIF2S3 Gene

Regulatory Elements for EIF2S3 Gene

Promoters for EIF2S3 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around EIF2S3 on UCSC Golden Path with GeneCards custom track

Genomic Location for EIF2S3 Gene

Chromosome:
X
Start:
24,054,716 bp from pter
End:
24,078,810 bp from pter
Size:
24,095 bases
Orientation:
Plus strand

Genomic View for EIF2S3 Gene

Genes around EIF2S3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
EIF2S3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for EIF2S3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for EIF2S3 Gene

Proteins for EIF2S3 Gene

  • Protein details for EIF2S3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P41091-IF2G_HUMAN
    Recommended name:
    Eukaryotic translation initiation factor 2 subunit 3
    Protein Accession:
    P41091
    Secondary Accessions:
    • A0A024RBY4
    • A8K2Y2
    • B2R5N2
    • B5BTZ4
    • Q53HK3

    Protein attributes for EIF2S3 Gene

    Size:
    472 amino acids
    Molecular mass:
    51109 Da
    Quaternary structure:
    • Heterotrimer composed of an alpha subunit, also called subunit 1 (encoded by EIF2S1), a beta subunit, also called subunit 2 (encoded by EIF2S2) and a gamma subunit, also called subunit 3 (encoded by EIF2S3).
    Miscellaneous:
    • Encoded by an chromosome X-linked gene which escapes inactivation. Does not have any homolog on chromosome Y.

neXtProt entry for EIF2S3 Gene

Proteomics data for EIF2S3 Gene at MOPED

Post-translational modifications for EIF2S3 Gene

  • Ubiquitination at Lys 90, Lys 121, Lys 196, and Lys 289
  • Modification sites at PhosphoSitePlus

Other Protein References for EIF2S3 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for EIF2S3 Gene

Domains & Families for EIF2S3 Gene

Suggested Antigen Peptide Sequences for EIF2S3 Gene

Graphical View of Domain Structure for InterPro Entry

P41091

UniProtKB/Swiss-Prot:

IF2G_HUMAN :
  • Contains 1 tr-type G (guanine nucleotide-binding) domain.
  • Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EIF2G subfamily.
Domain:
  • Contains 1 tr-type G (guanine nucleotide-binding) domain.
Family:
  • Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EIF2G subfamily.
genes like me logo Genes that share domains with EIF2S3: view

No data available for Gene Families for EIF2S3 Gene

Function for EIF2S3 Gene

Molecular function for EIF2S3 Gene

GENATLAS Biochemistry:
eukaryotic translocation initiation factor 2 gamma,escaping X-inactivation
UniProtKB/Swiss-Prot Function:
As a subunit of eukaryotic initiation factor 2 (eIF2), involved in the early steps of protein synthesis. In the presence of GTP, eIF2 forms a ternary complex with initiator tRNA Met-tRNAi and then recruits the 40S ribosomal complex, a step that determines the rate of protein translation. This step is followed by mRNA binding to form the 43S pre-initiation complex. Junction of the 60S ribosomal subunit to form the 80S initiation complex is preceded by hydrolysis of the GTP bound to eIF2 and release of an eIF2-GDP binary complex. In order for eIF2 to recycle and catalyze another round of initiation, the GDP bound to eIF2 must exchange with GTP by way of a reaction catalyzed by eIF2B (By similarity). Along with its paralog on chromosome Y, may contribute to spermatogenesis up to the round spermatid stage (By similarity).

Gene Ontology (GO) - Molecular Function for EIF2S3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 16288713
genes like me logo Genes that share ontologies with EIF2S3: view
genes like me logo Genes that share phenotypes with EIF2S3: view

Animal Model Products

  • Taconic Biosciences Mouse Models for EIF2S3

CRISPR Products

miRNA for EIF2S3 Gene

miRTarBase miRNAs that target EIF2S3

Inhibitory RNA Products

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for EIF2S3 Gene

Localization for EIF2S3 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for EIF2S3 Gene COMPARTMENTS Subcellular localization image for EIF2S3 gene
Compartment Confidence
cytosol 5
extracellular 5
nucleus 2
peroxisome 1

Gene Ontology (GO) - Cellular Components for EIF2S3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with EIF2S3: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for EIF2S3 Gene

Pathways & Interactions for EIF2S3 Gene

genes like me logo Genes that share pathways with EIF2S3: view

Pathways by source for EIF2S3 Gene

1 BioSystems pathway for EIF2S3 Gene
1 KEGG pathway for EIF2S3 Gene
2 Qiagen pathways for EIF2S3 Gene

Gene Ontology (GO) - Biological Process for EIF2S3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001731 formation of translation preinitiation complex IBA --
GO:0006413 translational initiation TAS --
GO:0055085 transmembrane transport TAS --
genes like me logo Genes that share ontologies with EIF2S3: view

No data available for SIGNOR curated interactions for EIF2S3 Gene

Drugs & Compounds for EIF2S3 Gene

(3) Drugs for EIF2S3 Gene - From: Novoseek, HMDB, and DrugBank

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Guanosine diphosphate Experimental Pharma Target 0
Guanosine triphosphate Experimental Pharma 0

(2) Additional Compounds for EIF2S3 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with EIF2S3: view

Transcripts for EIF2S3 Gene

Unigene Clusters for EIF2S3 Gene

Eukaryotic translation initiation factor 2, subunit 3 gamma, 52kDa:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for EIF2S3 Gene

No ASD Table

Relevant External Links for EIF2S3 Gene

GeneLoc Exon Structure for
EIF2S3
ECgene alternative splicing isoforms for
EIF2S3

Expression for EIF2S3 Gene

mRNA expression in normal human tissues for EIF2S3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for EIF2S3 Gene

This gene is overexpressed in Bone marrow stromal cell (9.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for EIF2S3 Gene



SOURCE GeneReport for Unigene cluster for EIF2S3 Gene Hs.539684

mRNA Expression by UniProt/SwissProt for EIF2S3 Gene

P41091-IF2G_HUMAN
Tissue specificity: Expressed in testis, brain, liver and muscle.
genes like me logo Genes that share expression patterns with EIF2S3: view

Protein tissue co-expression partners for EIF2S3 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues for EIF2S3 Gene

Orthologs for EIF2S3 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for EIF2S3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia EIF2S3 35
  • 98.52 (n)
  • 98.94 (a)
cow
(Bos Taurus)
Mammalia -- 36
  • 95 (a)
ManyToMany
-- 36
  • 96 (a)
ManyToMany
EIF2S3 36
  • 100 (a)
ManyToMany
EIF2S3 35
  • 93.29 (n)
  • 99.58 (a)
dog
(Canis familiaris)
Mammalia EIF2S3 35
  • 93.86 (n)
  • 99.79 (a)
-- 36
  • 100 (a)
OneToMany
mouse
(Mus musculus)
Mammalia Eif2s3x 16
Eif2s3x 36
  • 100 (a)
OneToMany
Eif2s3x 35
  • 90.89 (n)
  • 99.58 (a)
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 98 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 98 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Eif2s3x 35
  • 91.03 (n)
  • 99.79 (a)
chicken
(Gallus gallus)
Aves EIF2S3 36
  • 99 (a)
OneToMany
EIF2S3 35
  • 84.25 (n)
  • 98.73 (a)
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 97 (a)
OneToMany
African clawed frog
(Xenopus laevis)
Amphibia eif2s3-prov 35
tropical clawed frog
(Silurana tropicalis)
Amphibia eif2s3 35
  • 82.27 (n)
  • 97.25 (a)
Str.7629 35
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.8958 35
zebrafish
(Danio rerio)
Actinopterygii Dr.26653 35
eif2s3 35
  • 79.17 (n)
  • 96.4 (a)
eif2s3 36
  • 96 (a)
OneToMany
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP003597 35
  • 66.52 (n)
  • 83.44 (a)
fruit fly
(Drosophila melanogaster)
Insecta eIF-2gamma 35
  • 67.31 (n)
  • 81.45 (a)
eIF-2gamma 36
  • 80 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea Y39G10AR.8 37
  • 75 (a)
Y39G10AR.8 36
  • 73 (a)
OneToMany
CELE_Y39G10AR.8 35
  • 65.2 (n)
  • 75 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes GCD11 36
  • 63 (a)
OneToMany
GCD11 38
soybean
(Glycine max)
eudicotyledons Gma.16061 35
thale cress
(Arabidopsis thaliana)
eudicotyledons EIF2 GAMMA 35
  • 64.9 (n)
  • 72.35 (a)
rice
(Oryza sativa)
Liliopsida Os12g0607100 35
  • 66.59 (n)
  • 74.34 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 84 (a)
OneToMany
Species with no ortholog for EIF2S3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for EIF2S3 Gene

ENSEMBL:
Gene Tree for EIF2S3 (if available)
TreeFam:
Gene Tree for EIF2S3 (if available)

Paralogs for EIF2S3 Gene

Paralogs for EIF2S3 Gene

(1) SIMAP similar genes for EIF2S3 Gene using alignment to 2 proteins:

Pseudogenes.org Pseudogenes for EIF2S3 Gene

genes like me logo Genes that share paralogs with EIF2S3: view

Variants for EIF2S3 Gene

Sequence variations from dbSNP and Humsavar for EIF2S3 Gene

SNP ID Clin Chr 0X pos Sequence Context AA Info Type
rs16997659 - 24,057,745(+) CTTCA(A/G)ATTAG reference, missense
rs1129148 -- 24,078,782(+) GGAAC(A/C)CAAAT utr-variant-3-prime
rs2318792 -- 24,074,587(+) gacta(A/T)aatga intron-variant
rs4390116 -- 24,069,608(+) TTATC(C/T)TTTGT intron-variant
rs3827465 -- 24,054,421(+) GCCCC(A/C/G)CCTCC upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for EIF2S3 Gene

Variant ID Type Subtype PubMed ID
esv2740010 CNV Deletion 23290073
nsv524256 CNV Gain 19592680

Variation tolerance for EIF2S3 Gene

Residual Variation Intolerance Score: 27.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.68; 65.94% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for EIF2S3 Gene

HapMap Linkage Disequilibrium report
EIF2S3
Human Gene Mutation Database (HGMD)
EIF2S3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for EIF2S3 Gene

Disorders for EIF2S3 Gene

Relevant External Links for EIF2S3

Genetic Association Database (GAD)
EIF2S3
Human Genome Epidemiology (HuGE) Navigator
EIF2S3
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
EIF2S3

No disorders were found for EIF2S3 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for EIF2S3 Gene

Publications for EIF2S3 Gene

  1. Characterization of genes encoding translation initiation factor eIF- 2gamma in mouse and human: sex chromosome localization, escape from X- inactivation and evolution. (PMID: 9736774) Ehrmann I.E. … Scott D.M. (Hum. Mol. Genet. 1998) 2 3 4 67
  2. Translation initiation factor eIF-2. Cloning and expression of the human cDNA encoding the gamma-subunit. (PMID: 8106381) Gaspar N.J. … Merrick W.C. (J. Biol. Chem. 1994) 2 3
  3. Temporal proteomics of NGF-TrkA signaling identifies an inhibitory role for the E3 ligase Cbl-b in neuroblastoma cell differentiation. (PMID: 25921289) Emdal K.B. … Olsen J.V. (Sci Signal 2015) 3
  4. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  5. Panorama of ancient metazoan macromolecular complexes. (PMID: 26344197) Wan C. … Emili A. (Nature 2015) 3

Products for EIF2S3 Gene

Sources for EIF2S3 Gene

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