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Aliases for EIF2S1 Gene

Aliases for EIF2S1 Gene

  • Eukaryotic Translation Initiation Factor 2 Subunit Alpha 2 3 4 5
  • Eukaryotic Translation Initiation Factor 2, Subunit 1 Alpha, 35kDa 2 3
  • EIF-2-Alpha 3 4
  • EIF-2alpha 3 4
  • EIF-2A 3 4
  • EIF2A 3 4
  • Eukaryotic Translation Initiation Factor 2, Subunit 1 (Alpha, 35kD ) 2
  • EIF-2 3
  • EIF2 3

External Ids for EIF2S1 Gene

Previous HGNC Symbols for EIF2S1 Gene

  • EIF2

Previous GeneCards Identifiers for EIF2S1 Gene

  • GC14P065332
  • GC14P061620
  • GC14P065817
  • GC14P066896
  • GC14P067826
  • GC14P047996

Summaries for EIF2S1 Gene

Entrez Gene Summary for EIF2S1 Gene

  • The translation initiation factor EIF2 catalyzes the first regulated step of protein synthesis initiation, promoting the binding of the initiator tRNA to 40S ribosomal subunits. Binding occurs as a ternary complex of methionyl-tRNA, EIF2, and GTP. EIF2 is composed of 3 nonidentical subunits, the 36-kD EIF2-alpha subunit (EIF2S1), the 38-kD EIF2-beta subunit (EIF2S2; MIM 603908), and the 52-kD EIF2-gamma subunit (EIF2S3; MIM 300161). The rate of formation of the ternary complex is modulated by the phosphorylation state of EIF2-alpha (Ernst et al., 1987 [PubMed 2948954]).[supplied by OMIM, Feb 2010]

GeneCards Summary for EIF2S1 Gene

EIF2S1 (Eukaryotic Translation Initiation Factor 2 Subunit Alpha) is a Protein Coding gene. Diseases associated with EIF2S1 include vaccinia and wolcott-rallison syndrome. Among its related pathways are Gene Expression and Transport to the Golgi and subsequent modification. GO annotations related to this gene include nucleic acid binding and RNA binding.

UniProtKB/Swiss-Prot for EIF2S1 Gene

  • Functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA. This complex binds to a 40S ribosomal subunit, followed by mRNA binding to form a 43S preinitiation complex. Junction of the 60S ribosomal subunit to form the 80S initiation complex is preceded by hydrolysis of the GTP bound to eIF-2 and release of an eIF-2-GDP binary complex. In order for eIF-2 to recycle and catalyze another round of initiation, the GDP bound to eIF-2 must exchange with GTP by way of a reaction catalyzed by eIF-2B.

Tocris Summary for EIF2S1 Gene

  • Protein Ser/Thr phosphatases are a group of enzymes that catalyze the removal of phosphate groups from serine and/or threonine residues by hydrolysis of phosphoric acid monoesters. They oppose the action of kinases and phosphorylases and are involved in signal transduction.

Gene Wiki entry for EIF2S1 Gene

No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for EIF2S1 Gene

Genomics for EIF2S1 Gene

Regulatory Elements for EIF2S1 Gene

Promoters for EIF2S1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around EIF2S1 on UCSC Golden Path with GeneCards custom track

Genomic Location for EIF2S1 Gene

Chromosome:
14
Start:
67,359,997 bp from pter
End:
67,386,516 bp from pter
Size:
26,520 bases
Orientation:
Plus strand

Genomic View for EIF2S1 Gene

Genes around EIF2S1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
EIF2S1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for EIF2S1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for EIF2S1 Gene

Proteins for EIF2S1 Gene

  • Protein details for EIF2S1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P05198-IF2A_HUMAN
    Recommended name:
    Eukaryotic translation initiation factor 2 subunit 1
    Protein Accession:
    P05198

    Protein attributes for EIF2S1 Gene

    Size:
    315 amino acids
    Molecular mass:
    36112 Da
    Quaternary structure:
    • Heterotrimer composed of an alpha, a beta and a gamma chain. Component of an EIF2 complex at least composed of CELF1/CUGBP1, CALR, CALR3, EIF2S1, EIF2S2, HSP90B1 and HSPA5. Interaction with METAP2 protects EIF2S1 from inhibitory phosphorylation (By similarity). Interacts with ABCF1 isoform 2. Associates with ribosomes.

    Three dimensional structures from OCA and Proteopedia for EIF2S1 Gene

neXtProt entry for EIF2S1 Gene

Proteomics data for EIF2S1 Gene at MOPED

Post-translational modifications for EIF2S1 Gene

  • Substrate for at least 4 kinases: EIF2AK1/HRI, EIF2AK2/PKR, EIF2AK3/PERK and EIF2AK4/GCN2. Phosphorylation stabilizes the eIF-2/GDP/eIF-2B complex and prevents GDP/GTP exchange reaction, thus impairing the recycling of eIF-2 between successive rounds of initiation and leading to global inhibition of translation (PubMed:15207627, PubMed:18032499). Phosphorylated; phosphorylation on Ser-52 by the EIF2AK4/GCN2 protein kinase occurs in response to amino acid starvation and UV irradiation (By similarity).
  • Ubiquitination at Lys 101, Lys 123, Lys 141, Lys 143, Lys 190, Lys 209, Lys 226, and Lys 259
  • Modification sites at PhosphoSitePlus

Other Protein References for EIF2S1 Gene

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for EIF2S1 (eIF2-alpha)

No data available for DME Specific Peptides for EIF2S1 Gene

Domains & Families for EIF2S1 Gene

Graphical View of Domain Structure for InterPro Entry

P05198

UniProtKB/Swiss-Prot:

IF2A_HUMAN :
  • Contains 1 S1 motif domain.
  • Belongs to the eIF-2-alpha family.
Domain:
  • Contains 1 S1 motif domain.
Family:
  • Belongs to the eIF-2-alpha family.
genes like me logo Genes that share domains with EIF2S1: view

No data available for Gene Families for EIF2S1 Gene

Function for EIF2S1 Gene

Molecular function for EIF2S1 Gene

UniProtKB/Swiss-Prot Function:
Functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA. This complex binds to a 40S ribosomal subunit, followed by mRNA binding to form a 43S preinitiation complex. Junction of the 60S ribosomal subunit to form the 80S initiation complex is preceded by hydrolysis of the GTP bound to eIF-2 and release of an eIF-2-GDP binary complex. In order for eIF-2 to recycle and catalyze another round of initiation, the GDP bound to eIF-2 must exchange with GTP by way of a reaction catalyzed by eIF-2B.

Gene Ontology (GO) - Molecular Function for EIF2S1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 9431994
genes like me logo Genes that share ontologies with EIF2S1: view
genes like me logo Genes that share phenotypes with EIF2S1: view

Animal Model Products

miRNA Products

Inhibitory RNA Products

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for EIF2S1 Gene

Localization for EIF2S1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for EIF2S1 Gene

Cytoplasmic granule. Note=The cytoplasmic granules are stress granules which are a dense aggregation in the cytosol composed of proteins and RNAs that appear when the cell is under stress. Colocalizes with NANOS3 in the stress granules (By similarity). {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for EIF2S1 Gene COMPARTMENTS Subcellular localization image for EIF2S1 gene
Compartment Confidence
cytosol 5
extracellular 5
nucleus 4
endoplasmic reticulum 3
mitochondrion 2
peroxisome 2
lysosome 1
vacuole 1

Gene Ontology (GO) - Cellular Components for EIF2S1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005840 ribosome IBA --
GO:0005850 eukaryotic translation initiation factor 2 complex IEA,IBA --
GO:0016020 membrane IDA 19946888
GO:0097451 glial limiting end-foot IEA --
genes like me logo Genes that share ontologies with EIF2S1: view

Pathways & Interactions for EIF2S1 Gene

genes like me logo Genes that share pathways with EIF2S1: view

SIGNOR curated interactions for EIF2S1 Gene

Is activated by:
Is inactivated by:

Gene Ontology (GO) - Biological Process for EIF2S1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006413 translational initiation IEA,TAS --
GO:0010467 gene expression TAS --
GO:0032057 negative regulation of translational initiation in response to stress ISS --
GO:0034198 cellular response to amino acid starvation ISS --
GO:0034605 cellular response to heat IEA --
genes like me logo Genes that share ontologies with EIF2S1: view

Drugs & Compounds for EIF2S1 Gene

(26) Drugs for EIF2S1 Gene - From: Novoseek, Tocris, and HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Okadaic acid Experimental Pharma Protein phosphatase 1 and 2A inhibitor 0
Guanosine triphosphate Experimental Pharma 0
Calyculin A Experimental Pharma Protein phosphatase 1 and 2A inhibitor 0
Cyclosporin A Pharma Antagonist Immunosuppressive agent, Calcineurin inhibitor 0

(27) Additional Compounds for EIF2S1 Gene - From: Novoseek and Tocris

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Ceramide
3102-57-6
DL-AP3
20263-06-3

(5) Tocris Compounds for EIF2S1 Gene

Compound Action Cas Number
Calyculin A Protein phosphatase 1 and 2A inhibitor 101932-71-2
Ceramide Ser/Thr protein phosphatase activator 3102-57-6
Cyclosporin A Calcineurin inhibitor 59865-13-3
DL-AP3 Group I mGlu antagonist 20263-06-3
Okadaic acid Protein phosphatase 1 and 2A inhibitor 78111-17-8
genes like me logo Genes that share compounds with EIF2S1: view

Transcripts for EIF2S1 Gene

Unigene Clusters for EIF2S1 Gene

Eukaryotic translation initiation factor 2, subunit 1 alpha, 35kDa:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for EIF2S1 Gene

No ASD Table

Relevant External Links for EIF2S1 Gene

GeneLoc Exon Structure for
EIF2S1
ECgene alternative splicing isoforms for
EIF2S1

Expression for EIF2S1 Gene

mRNA expression in normal human tissues for EIF2S1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for EIF2S1 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (6.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for EIF2S1 Gene



SOURCE GeneReport for Unigene cluster for EIF2S1 Gene Hs.151777

genes like me logo Genes that share expression patterns with EIF2S1: view

Protein tissue co-expression partners for EIF2S1 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for EIF2S1 Gene

Orthologs for EIF2S1 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for EIF2S1 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia EIF2S1 35
  • 94.81 (n)
  • 99.05 (a)
EIF2S1 36
  • 99 (a)
OneToOne
dog
(Canis familiaris)
Mammalia EIF2S1 35
  • 94.81 (n)
  • 99.05 (a)
EIF2S1 36
  • 99 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Eif2s1 35
  • 93.33 (n)
  • 99.05 (a)
Eif2s1 16
Eif2s1 36
  • 99 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia EIF2S1 35
  • 99.79 (n)
  • 100 (a)
EIF2S1 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Eif2s1 35
  • 93.33 (n)
  • 99.05 (a)
oppossum
(Monodelphis domestica)
Mammalia EIF2S1 36
  • 98 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia EIF2S1 36
  • 98 (a)
OneToOne
chicken
(Gallus gallus)
Aves EIF2S1 35
  • 84.95 (n)
  • 97.57 (a)
EIF2S1 36
  • 97 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia EIF2S1 36
  • 97 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia eif2s1 35
  • 81.27 (n)
  • 93.65 (a)
Str.6631 35
African clawed frog
(Xenopus laevis)
Amphibia eif2s1-prov 35
zebrafish
(Danio rerio)
Actinopterygii -- 35
eif2s1b 35
  • 77.25 (n)
  • 94.29 (a)
eif2s1a 36
  • 94 (a)
OneToMany
eif2s1b 36
  • 94 (a)
OneToMany
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.7988 35
fruit fly
(Drosophila melanogaster)
Insecta eIF-2alpha 37
  • 62 (a)
eIF-2alpha 35
  • 58.14 (n)
  • 62.3 (a)
eIF-2alpha 36
  • 57 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP011190 35
  • 61.11 (n)
  • 68 (a)
worm
(Caenorhabditis elegans)
Secernentea Y37E3.10 37
  • 58 (a)
Y37E3.10 35
  • 60.77 (n)
  • 58.5 (a)
Y37E3.10 36
  • 51 (a)
OneToOne
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AGR320W 35
  • 57.97 (n)
  • 55.85 (a)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0A11814g 35
  • 60.31 (n)
  • 57.53 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes SUI2 35
  • 61.32 (n)
  • 54.85 (a)
SUI2 36
  • 54 (a)
OneToOne
SUI2 38
thale cress
(Arabidopsis thaliana)
eudicotyledons AT2G40290 35
  • 56.12 (n)
  • 51.52 (a)
Alicante grape
(Vitis vinifera)
eudicotyledons Vvi.7752 35
rice
(Oryza sativa)
Liliopsida Os.11646 35
Os07g0692800 35
  • 54.78 (n)
  • 54.33 (a)
corn
(Zea mays)
Liliopsida Zm.4283 35
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.1492 35
bread mold
(Neurospora crassa)
Ascomycetes NCU08277 35
  • 55.63 (n)
  • 54.39 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes tif211 35
  • 59.82 (n)
  • 56.23 (a)
Species with no ortholog for EIF2S1:
  • Actinobacteria (Mycobacterium tuberculosis)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for EIF2S1 Gene

ENSEMBL:
Gene Tree for EIF2S1 (if available)
TreeFam:
Gene Tree for EIF2S1 (if available)

Paralogs for EIF2S1 Gene

No data available for Paralogs for EIF2S1 Gene

Variants for EIF2S1 Gene

Sequence variations from dbSNP and Humsavar for EIF2S1 Gene

SNP ID Clin Chr 14 pos Sequence Context AA Info Type
rs2094163 -- 67,370,237(+) TTAGG(A/G)CCATT intron-variant
rs2296560 -- 67,382,177(+) ATACA(C/T)GGAAA intron-variant
rs2296561 -- 67,382,422(+) CATAA(A/T)TGAAT intron-variant
rs3067321 -- 67,375,283(+) tgtgt(-/GTGT)CACAA intron-variant
rs3067323 -- 67,376,163(+) GAGCA(-/CT)CTCTG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for EIF2S1 Gene

Variant ID Type Subtype PubMed ID
esv2751285 CNV Gain 17911159
nsv832821 CNV Gain 17160897
nsv456331 CNV Gain 19166990
nsv470651 CNV Gain 18288195
nsv509539 CNV Insertion 20534489

Variation tolerance for EIF2S1 Gene

Residual Variation Intolerance Score: 46.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.31; 6.95% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for EIF2S1 Gene

HapMap Linkage Disequilibrium report
EIF2S1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for EIF2S1 Gene

Disorders for EIF2S1 Gene

MalaCards: The human disease database

(2) MalaCards diseases for EIF2S1 Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
vaccinia
wolcott-rallison syndrome
  • romano-ward syndrome
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for EIF2S1

Genetic Association Database (GAD)
EIF2S1
Human Genome Epidemiology (HuGE) Navigator
EIF2S1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
EIF2S1
genes like me logo Genes that share disorders with EIF2S1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for EIF2S1 Gene

Publications for EIF2S1 Gene

  1. Cloning and sequencing of complementary DNAs encoding the alpha- subunit of translational initiation factor eIF-2. Characterization of the protein and its messenger RNA. (PMID: 2948954) Ernst H. … Hershey J.W.B. (J. Biol. Chem. 1987) 2 3 4 67
  2. OGFOD1, a novel modulator of eukaryotic translation initiation factor 2alpha phosphorylation and the cellular response to stress. (PMID: 20154146) Wehner K.A. … Sarnow P. (Mol. Cell. Biol. 2010) 3 23
  3. Sorafenib with doxorubicin augments cytotoxicity to renal cell cancer through PERK inhibition. (PMID: 20428777) Shiota M. … Naito S. (Int. J. Oncol. 2010) 3 23
  4. Viral host-range factor C7 or K1 is essential for modified vaccinia virus Ankara late gene expression in human and murine cells, irrespective of their capacity to inhibit protein kinase R-mediated phosphorylation of eukaryotic translation initiation factor 2alpha. (PMID: 19846675) Backes S. … Sutter G. (J. Gen. Virol. 2010) 3 23
  5. An upstream open reading frame regulates translation of GADD34 during cellular stresses that induce eIF2alpha phosphorylation. (PMID: 19131336) Lee Y.Y. … Jan E. (J. Biol. Chem. 2009) 3 23

Products for EIF2S1 Gene

Sources for EIF2S1 Gene

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