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EIF2S1 Gene

protein-coding   GIFtS: 69
GCID: GC14P067826

Eukaryotic Translation Initiation Factor 2, Subunit 1 Alpha,...

(Previous names: eukaryotic translation initiation factor 2, subunit 1 (alpha,...)
(Previous symbol: EIF2)
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Eukaryotic Translation Initiation Factor 2, Subunit 1 Alpha, 35kDa1 2     EIF-22
EIF21 2     EIF-2A2
Eukaryotic Translation Initiation Factor 2 Subunit Alpha2 3     EIF-2alpha2
EIF2A2 3     Eukaryotic Translation Initiation Factor 2 Subunit 12
eIF-2-alpha2 3     eIF-2A3
Eukaryotic Translation Initiation Factor 2, Subunit 1 (Alpha, 35kD )1     eIF-2alpha3

External Ids:    HGNC: 32651   Entrez Gene: 19652   Ensembl: ENSG000001340017   OMIM: 6039075   UniProtKB: P051983   

Export aliases for EIF2S1 gene to outside databases

Previous GC identifers: GC14P065332 GC14P061620 GC14P065817 GC14P066896 GC14P047996


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for EIF2S1 Gene:
The translation initiation factor EIF2 catalyzes the first regulated step of protein synthesis initiation,
promoting the binding of the initiator tRNA to 40S ribosomal subunits. Binding occurs as a ternary complex of
methionyl-tRNA, EIF2, and GTP. EIF2 is composed of 3 nonidentical subunits, the 36-kD EIF2-alpha subunit
(EIF2S1), the 38-kD EIF2-beta subunit (EIF2S2; MIM 603908), and the 52-kD EIF2-gamma subunit (EIF2S3; MIM
300161). The rate of formation of the ternary complex is modulated by the phosphorylation state of EIF2-alpha
(Ernst et al., 1987 (PubMed 2948954)).(supplied by OMIM, Feb 2010)

GeneCards Summary for EIF2S1 Gene:
EIF2S1 (eukaryotic translation initiation factor 2, subunit 1 alpha, 35kDa) is a protein-coding gene. GO annotations related to this gene include ribosome binding and translation initiation factor activity.

UniProtKB/Swiss-Prot: IF2A_HUMAN, P05198
Function: Functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator
tRNA. This complex binds to a 40S ribosomal subunit, followed by mRNA binding to form a 43S preinitiation
complex. Junction of the 60S ribosomal subunit to form the 80S initiation complex is preceded by hydrolysis of
the GTP bound to eIF-2 and release of an eIF-2-GDP binary complex. In order for eIF-2 to recycle and catalyze
another round of initiation, the GDP bound to eIF-2 must exchange with GTP by way of a reaction catalyzed by
eIF-2B

summary for EIF2S1 Gene:
Eukaryotic translation initiation factor 2A (eIF2A) is involved in the first step of the initiation of
protein synthesis. It forms a complex with GTP and initiator tRNA. EIF2 is composed of three subunits,
namely EIF2-alpha (EIF2S1), EIF2-beta (EIF2S2) and EIF2-gamma (EIF2S3).

Gene Wiki entry for EIF2S1 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000014.8  NC_018925.2  NT_026437.13  
Regulatory elements:
   Regulatory transcription factor binding sites in the EIF2S1 gene promoter:
         STAT1   AP-1   p53   ATF-2   STAT1beta   IRF-1   C/EBPalpha   PPAR-gamma1   c-Jun   PPAR-gamma2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidEIF2S1 promoter sequence
   Search Chromatin IP Primers for EIF2S1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat EIF2S1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 14q23.3   Ensembl cytogenetic band:  14q23.3   HGNC cytogenetic band: 14q21.3

EIF2S1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
EIF2S1 gene location

GeneLoc information about chromosome 14         GeneLoc Exon Structure

GeneLoc location for GC14P067826:  view genomic region     (about GC identifiers)

Start:
67,826,714 bp from pter      End:
67,853,233 bp from pter
Size:
26,520 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: IF2A_HUMAN, P05198 (See protein sequence)
Recommended Name: Eukaryotic translation initiation factor 2 subunit 1  
Size: 315 amino acids; 36112 Da
Subunit: Heterotrimer composed of an alpha, a beta and a gamma chain. Component of an EIF2 complex at least
composed of CELF1/CUGBP1, CALR, CALR3, EIF2S1, EIF2S2, HSP90B1 and HSPA5. Interaction with METAP2 protects EIF2S1
from inhibitory phosphorylation (By similarity). Interacts with ABCF1 isoform 2. Associates with ribosomes
2 PDB 3D structures from and Proteopedia for EIF2S1:
1KL9 (3D)        1Q8K (3D)    

Explore the universe of human proteins at neXtProt for EIF2S1: NX_P05198

Explore proteomics data for EIF2S1 at MOPED

Post-translational modifications: 

  • Substrate for at least 4 kinases: EIF2AK3/PERK, GCN2, HRI and PKR. Phosphorylation stabilizes the eIF-2/GDP/eIF-2B
    complex and prevents GDP/GTP exchange reaction, thus impairing the recycling of eIF-2 between successive rounds
    of initiation and leading to global inhibition of translation. In case of infection by vaccinia virus or
    rotavirus A, eIF2S1 phosphorylation state is modulated1
  • Ubiquitination2 at Lys101, Lys106, Lys123, Lys141, Lys143, Lys190, Lys209, Lys226, Lys259
  • Modification sites at PhosphoSitePlus

  • See EIF2S1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_004085.1  
    ENSEMBL proteins: 
     ENSP00000256383   ENSP00000451975   ENSP00000425299   ENSP00000452034  
    Reactome Protein details: P05198

    EIF2S1 Human Recombinant Protein Products:

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    ProSpec Recombinant Protein for EIF2S1
    Cloud-Clone Corp. Proteins for EIF2S1

     
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    antibodies-online proteins for EIF2S1 (18 products) 

     
    antibodies-online peptides for EIF2S1

    EIF2S1 Antibody Products:

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    antibodies-online antibodies for EIF2S1 (90 products) 

    EIF2S1 Assay Products:

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    Selected InterPro protein domains (see all 6):
     IPR012340 NA-bd_OB-fold
     IPR003029 Rbsml_prot_S1_RNA-bd_dom
     IPR011488 TIF_2_asu
     IPR024055 TIF2_asu_C
     IPR024054 TIF2_asu_middle

    Graphical View of Domain Structure for InterPro Entry P05198

    ProtoNet protein and cluster: P05198

    2 Blocks protein domains:
    IPB003029 RNA binding S1
    IPB011488 Eukaryotic translation initiation factor 2


    UniProtKB/Swiss-Prot: IF2A_HUMAN, P05198
    Similarity: Belongs to the eIF-2-alpha family
    Similarity: Contains 1 S1 motif domain


    Find genes that share domains with EIF2S1           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: IF2A_HUMAN, P05198
    Function: Functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator
    tRNA. This complex binds to a 40S ribosomal subunit, followed by mRNA binding to form a 43S preinitiation
    complex. Junction of the 60S ribosomal subunit to form the 80S initiation complex is preceded by hydrolysis of
    the GTP bound to eIF-2 and release of an eIF-2-GDP binary complex. In order for eIF-2 to recycle and catalyze
    another round of initiation, the GDP bound to eIF-2 must exchange with GTP by way of a reaction catalyzed by
    eIF-2B

         Gene Ontology (GO): 5 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003723RNA binding ----
    GO:0003743translation initiation factor activity IDA16289705
    GO:0005515protein binding IPI11500362
    GO:0043022ribosome binding IDA17894550
    GO:0044822poly(A) RNA binding IDA--
         
    Find genes that share ontologies with EIF2S1           About GenesLikeMe


    Phenotypes:
         3 GenomeRNAi human phenotypes for EIF2S1:
     Decreased influenza A virus in  Decreased viability of wild-ty  Increased gamma-H2AX phosphory 

         6 MGI mutant phenotypes (inferred from 1 allele(MGI details for Eif2s1):
     behavior/neurological  endocrine/exocrine gland  growth/size/body  hematopoietic system  homeostasis/metabolism 
     mortality/aging 

    Find genes that share phenotypes with EIF2S1           About GenesLikeMe

    Animal Models:
       genOway: Develop your customized and physiologically relevant rodent model for EIF2S1

    miRNA
    Products:
        
    miRTarBase miRNAs that target EIF2S1:
    hsa-mir-375 (MIRT019778), hsa-mir-222-3p (MIRT046815), hsa-mir-192-5p (MIRT026383), hsa-mir-21-5p (MIRT004813)

    Block miRNA regulation of human, mouse, rat EIF2S1 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate EIF2S1 (see all 82):
    hsa-miR-124* hsa-miR-582-3p hsa-miR-520e hsa-miR-520f hsa-miR-1260b hsa-miR-3622b-3p hsa-miR-1243 hsa-miR-556-3p
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat EIF2S1

    Gene Editing
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    Clone
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    GenScript: all cDNA clones in your preferred vector: EIF2S1 (NM_004094)
    Sino Biological Human cDNA Clone for EIF2S1
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for EIF2S1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat EIF2S1
    Addgene plasmids for EIF2S1 

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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for EIF2S1


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    IF2A_HUMAN, P05198: Cytoplasmic granule (By similarity). Note=The cytoplasmic granules are stress granules which
    are a dense aggregation in the cytosol composed of proteins and RNAs that appear when the cell is under stress.
    Colocalizes with NANOS3 in the stress granules (By similarity)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol4
    endoplasmic reticulum3
    nucleus2
    peroxisome2
    extracellular1
    mitochondrion1
    vacuole1

    Gene Ontology (GO): Selected cellular component terms (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IEA--
    GO:0005737cytoplasm ----
    GO:0005829cytosol TAS--
    GO:0005844polysome TAS2948954
    GO:0005850eukaryotic translation initiation factor 2 complex IEA--

    Find genes that share ontologies with EIF2S1           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for EIF2S1 About   (see all 20)  
    See pathways by source

    SuperPathContained pathways About
    1Translation Insulin regulation of translation
    Translation Insulin regulation of translation0.59
    Recycling of eIF2-GDP0.00
    Translation Regulation activity of EIF20.47
    2Influenza Viral RNA Transcription and Replication
    L13a-mediated translational silencing of Ceruloplasmin expression0.94
    Eukaryotic Translation Initiation0.89
    GTP hydrolysis and joining of the 60S ribosomal subunit0.93
    Translation0.82
    Cap-dependent Translation Initiation0.89
    3Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S
    Translation initiation complex formation0.91
    Formation of the ternary complex, and subsequently, the 43S complex0.91
    Ribosomal scanning and start codon recognition0.91
    Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S0.90
    4Influenza A
    Influenza A0.34
    Herpes simplex infection0.33
    Measles0.34
    5PERK regulated gene expression
    PERK regulated gene expression0.90


    Find genes that share SuperPaths with EIF2S1           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    4 Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for EIF2S1
        GSK3 Signaling
    PKR Pathway
    Activation of NF-KappaB by PKR
    eIF2 Pathway

    1 Cell Signaling Technology (CST) Pathway for EIF2S1
        Translational Control

    2 GeneGo (Thomson Reuters) Pathways for EIF2S1
        Translation Insulin regulation of translation
    Translation Regulation of EIF2 activity

    3 BioSystems Pathways for EIF2S1
        Translation Factors
    BDNF signaling pathway
    Validated targets of C-MYC transcriptional activation


    Selected Reactome Pathways for EIF2S1 (see all 7)
        Formation of the ternary complex, and subsequently, the 43S complex
    L13a-mediated translational silencing of Ceruloplasmin expression
    GTP hydrolysis and joining of the 60S ribosomal subunit
    PERK regulates gene expression
    Ribosomal scanning and start codon recognition


    Selected Kegg Pathways  (Kegg details for EIF2S1) (see all 7):
        RNA transport
    Protein processing in endoplasmic reticulum
    Non-alcoholic fatty liver disease (NAFLD)
    Hepatitis C
    Measles

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for EIF2S1
    Interactions:

        GeneGlobe Interaction Network for EIF2S1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for EIF2S1 (P051981, 2, 3 ENSP000002563834) via UniProtKB, MINT, STRING, and/or I2D (see all 814)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    HIST1H4AP628053I2D: score=1 
    HIST1H4BP628053I2D: score=1 
    HIST1H4CP628053I2D: score=1 
    HIST1H4DP628053I2D: score=1 
    HIST1H4EP628053I2D: score=1 
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006412translation TAS--
    GO:0006413translational initiation TAS--
    GO:0006987activation of signaling protein activity involved in unfolded protein response TAS--
    GO:0010467gene expression TAS--
    GO:0030968endoplasmic reticulum unfolded protein response TAS--

    Find genes that share ontologies with EIF2S1           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Compounds for EIF2S1 available from Tocris Bioscience    About this table
    CompoundAction CAS #
    SalubrinalSelective inhibitor of eIF2alpha dephosphorylation[405060-95-9]
    FK 506Potent calcineurin inhibitor; immunosuppressant[104987-11-3]
    Cyclosporin ACalcineurin inhibitor[59865-13-3]
    Okadaic acidProtein phosphatase 1 and 2A inhibitor[78111-17-8]
    Calyculin AProtein phosphatase 1 and 2A inhibitor[101932-71-2]

    1 HMDB Compound for EIF2S1    About this table
    CompoundSynonyms CAS #PubMed Ids
    Guanosine triphosphate5'-GTP (see all 10)86-01-1--

    Selected Novoseek inferred chemical compound relationships for EIF2S1 gene (see all 49)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    tunicamycin 71.8 10 17438523 (2), 19100962 (1), 19007793 (1), 19193809 (1) (see all 6)
    thapsigargin 60.6 10 20022965 (2), 19100962 (1), 19193809 (1), 19835916 (1)
    pactamycin 58.4 1 8619603 (1)
    polyinosinic-polycytidylic acid 55.5 4 10400313 (1), 10432301 (1), 10823866 (1), 12590973 (1)
    rapamycin 51.2 6 16483933 (1), 14726531 (1), 17331981 (1), 18219697 (1) (see all 5)
    arsenite 50.6 9 15788408 (2), 9867869 (1), 11809833 (1), 19878647 (1) (see all 7)
    threonine 48 9 10400313 (1), 11956076 (1), 17998206 (1), 12975376 (1) (see all 8)
    bortezomib 42.9 6 20022965 (2), 16357160 (2)
    gdp 42.1 17 2076109 (3), 20485439 (2), 7918624 (2), 10734073 (1) (see all 7)
    cycloheximide 40.7 9 9867869 (3), 14690445 (2), 20171949 (1), 17082262 (1) (see all 6)



    Find genes that share compounds with EIF2S1           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for EIF2S1 gene: 
    NM_004094.4  

    Unigene Cluster for EIF2S1:

    Eukaryotic translation initiation factor 2, subunit 1 alpha, 35kDa
    Hs.151777  [show with all ESTs]
    Unigene Representative Sequence: NM_004094
    6 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000256383(uc001xjg.3) ENST00000556724 ENST00000557310 ENST00000466499
    ENST00000555876 ENST00000554332
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    Selected qRT-PCR Assays for microRNAs that regulate EIF2S1 (see all 82):
    hsa-miR-124* hsa-miR-582-3p hsa-miR-520e hsa-miR-520f hsa-miR-1260b hsa-miR-3622b-3p hsa-miR-1243 hsa-miR-556-3p
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      QuantiFast Probe-based Assays in human, mouse, rat EIF2S1

    Additional mRNA sequence: 

    AK297244.1 AK312442.1 BC002513.2 BX161521.1 D28379.1 J02645.1 U26032.1 

    Selected DOTS entries (see all 25):

    DT.117457  DT.95164142  DT.100858715  DT.100858713  DT.95164146  DT.117456  DT.100858707  DT.100858709 
    DT.100728945  DT.120743165  DT.100763086  DT.100834711  DT.120743250  DT.120743254  DT.120743298  DT.120743299 
    DT.87016005  DT.91698754  DT.95201784  DT.95201793  DT.100044784  DT.100717904  DT.95164140  DT.95201792 

    Selected AceView cDNA sequences (see all 549):

    BI759091 BU679192 BU189060 AA777807 BU624131 AA832194 CA442489 CA418555 
    AA630457 BM765724 BU615541 BU615420 AA424595 AA832271 BQ020496 AA648938 
    BX403994 BM971797 BX161521 CB158139 BP371400 CF594283 AI361472 J02645 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    EIF2S1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AAATGCCCTC
    EIF2S1 Expression
    About this image

    EIF2S1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    EIF2S1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.151777
        Custom PCR Arrays for EIF2S1
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of eukaryotes.

    Orthologs for EIF2S1 gene from Selected species (see all 26)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Eif2s11 , 5 eukaryotic translation initiation factor 2, subunit more1, 5 93.33(n)1
    99.05(a)1
      12 (35.51 cM)5
    136651  NM_026114.31  NP_080390.11 
     788618195 
    chicken
    (Gallus gallus)
    Aves EIF2S11 eukaryotic translation initiation factor 2, subunit more 84.95(n)
    97.57(a)
      423279  NM_001006477.1  NP_001006477.1 
    lizard
    (Anolis carolinensis)
    Reptilia EIF2S16
    eukaryotic translation initiation factor 2, subuni...
    97(a)
    1 ↔ 1
    GL343272.1(1210142-1220292)
    African clawed frog
    (Xenopus laevis)
    Amphibia eif2s1-prov2 eukaryotic translation initiation factor 2, subunit more 81(n)    BC046576.1 
    zebrafish
    (Danio rerio)
    Actinopterygii BC049468.12   -- 79.19(n)   321807  BC049468.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta eIF-2alpha1 , 3 translational initiation translation
    initiation more3
    eukaryotic translation Initiation Factor 2alpha1
    62(a)3
    58.14(n)1
    62.3(a)1
      14C63
    326171  NM_132902.31  NP_573130.11 
    worm
    (Caenorhabditis elegans)
    Secernentea Y37E3.101 , 3 Y37E3.101 58(a)3
    60.77(n)1
    58.5(a)1
      I(2072691-2076102)3
    1717691  NM_058529.31  NP_490930.11 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes SUI2(YJR007W)4
    SUI21
    Alpha subunit of the translation initiation factor more4
    SUI21
    61.32(n)1
    54.85(a)1
      10(451020-451934)4
    8534631, 4  NP_012540.31  NP_012540.14 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons AT2G402901 AT2G40290 56.12(n)
    51.52(a)
      818621  NM_129587.2  NP_565927.1 
    rice
    (Oryza sativa)
    Liliopsida Os.116462 Oryza sativa (japonica cultivar-group) cDNA clone0 more 68.86(n)    AK104149.1 


    ENSEMBL Gene Tree for EIF2S1 (if available)
    TreeFam Gene Tree for EIF2S1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for EIF2S1 (see all 488)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 14 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1848087881,2
    --67828727(+) CTTTTC/TTTTTT 1 -- int10--------
    rs2007878891,2
    --67828823(+) GCCTC-/TTGCCC 1 -- int10--------
    rs1414524521,2
    C--67828905(+) CTAATG/TTTGGT 1 -- int10--------
    rs1891420151,2
    --67828932(+) GGGTTC/TCACCA 1 -- int10--------
    rs1450820711,2
    C--67829052(+) CTTTC-/TTGTTGTA 1 -- int10--------
    rs1165939041,2
    F--67829132(+) AATACC/TTTCTT 1 -- int11Minor allele frequency- T:0.01WA 118
    rs37597561,2
    C,F--67829147(+) TTTCAA/GTATTT 1 -- int12Minor allele frequency- G:0.04EA 1602
    rs1504075451,2
    --67829274(+) CTTTCC/TCAAGC 1 -- int10--------
    rs1815505721,2
    --67829326(+) GGCTAG/TAGTTG 1 -- int10--------
    rs1420722121,2
    C--67829454(+) AATGA-/TTTTTT 1 -- int10--------

    HapMap Linkage Disequilibrium report for EIF2S1 (67826714 - 67853233 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 5 variations for EIF2S1:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv509539CNV Insertion20534489
    nsv470651CNV Gain18288195
    esv2751285CNV Gain17911159
    nsv832821CNV Gain17160897
    nsv456331CNV Gain19166990

    Site Specific Mutation Identification with PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 603907    OMIM disorders: --

    1 disease from the University of Copenhagen DISEASES database for EIF2S1:
    Brain ischemia

    Find genes that share disorders with EIF2S1           About GenesLikeMe

    Selected Novoseek inferred disease relationships for EIF2S1 gene (see all 24)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    wolcott-rallison syndrome 70.5 1 12475790 (1)
    virus infection 45 17 19131336 (1), 15060162 (1), 15705855 (1), 19043413 (1) (see all 11)
    cancer 32.8 14 18087277 (3), 15456240 (1), 17531337 (1), 19190324 (1) (see all 5)
    brain ischemia 28.8 3 17288737 (3)
    herpes simplex 28.3 9 9696792 (2), 9023344 (1), 11070019 (1), 15705855 (1) (see all 8)
    shock 24.9 9 16505970 (2), 11689689 (2), 19936221 (1), 7930798 (1) (see all 5)
    tumors 20 14 16472113 (2), 18007663 (1), 19716858 (1), 17113348 (1) (see all 9)
    neurodegenerative diseases 17.6 1 11238455 (1)
    leukemia 11.5 3 20110807 (1), 17548474 (1)
    alzheimers disease 10.4 5 12445160 (1), 12975376 (1), 19017641 (1), 12499843 (1)

    Genetic Association Database (GAD): EIF2S1
    Human Genome Epidemiology (HuGE) Navigator: EIF2S1 (2 documents)

    Export disorders for EIF2S1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for EIF2S1 gene, integrated from 10 sources (see all 520):
    (articles sorted by number of sources associating them with EIF2S1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Cloning and sequencing of complementary DNAs encoding the alpha- subunit of translational initiation factor eIF-2. Characterization of the protein and its messenger RNA. (PubMed id 2948954)1, 2, 3 Ernst H.... Hershey J.W.B. (J. Biol. Chem. 1987)
    2. Solution structure of human initiation factor eIF2alpha reveals homology to the elongation factor eEF1B. (PubMed id 15341733)1, 2, 9 Ito T.... Wagner G. (Structure 2004)
    3. A pharmacogenetic study of polymorphisms in interferon pathway genes and response to interferon-alpha treatment in chronic hepatitis B patients. (PubMed id 19559055)1, 4 Wu X....Liu Y. (Antiviral Res. 2009)
    4. The N-terminal region of ABC50 interacts with eukaryotic initiation factor eIF2 and is a target for regulatory phosphorylation by CK2. (PubMed id 17894550)1, 2 Paytubi S.... Proud C.G. (Biochem. J. 2008)
    5. Inhibition of PKR by vaccinia virus: role of the N- and C-terminal domains of E3L. (PubMed id 15207627)1, 2 Langland J.O. and Jacobs B.L. (Virology 2004)
    6. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    7. Genetic polymorphisms in interferon pathway and response to interferon treatment in hepatitis B patients: A pilot study. (PubMed id 12447867)1, 4 King J.K....Chen P.J. (Hepatology 2002)
    8. Crystal structure of the N-terminal segment of human eukaryotic translation initiation factor 2alpha. (PubMed id 11859078)1, 2 Nonato M.C.... Clardy J. (J. Biol. Chem. 2002)
    9. Phosphorylation of eukaryotic initiation factor-2alpha (eIF2alpha) is associated with neuronal degeneration in Alzheimer's disease. (PubMed id 12499843)1, 9 Chang R.C....Hugon J. (Neuroreport 2002)
    10. Identification of caspase 3-mediated cleavage and functional alteration of eukaryotic initiation factor 2alpha in apoptosis. (PubMed id 10734073)1, 9 Marissen W.E....Lloyd R.E. (J. Biol. Chem. 2000)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 1965 HGNC: 3265 AceView: EIF2S1 Ensembl:ENSG00000134001 euGenes: HUgn1965
    ECgene: EIF2S1 Kegg: 1965 H-InvDB: EIF2S1

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for EIF2S1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for EIF2S1 gene:
    Search GeneIP for patents involving EIF2S1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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