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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

EIF2S1 Gene

protein-coding   GIFtS: 69
GCID: GC14P067826

eukaryotic translation initiation factor 2, subunit 1 alpha,...

(Previous names: eukaryotic translation initiation factor 2, subunit 1 (alpha,...)
(Previous symbol: EIF2)
 Explore 51 diseases affiliated with
EIF2S1 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for EIF2S1    

Aliases
for EIF2S1 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Eukaryotic Translation Initiation Factor 2, Subunit 1 Alpha, 35kDa1 2     Eukaryotic Translation Initiation Factor 2, Subunit 1 (Alpha, 35kD )1
EIF2A1 2 3     EIF-22
EIF-2alpha1 2     EIF-2A2
EIF21 2     Eukaryotic Translation Initiation Factor 2 Subunit 12
Eukaryotic Translation Initiation Factor 2 Subunit Alpha2 3     EIF-2A2
EIF-2-Alpha1     EIF-2alpha1 2

External Ids:    HGNC: 32651   Entrez Gene: 19652   Ensembl: ENSG000001340017   OMIM: 6039075   UniProtKB: P051983   

Export aliases for EIF2S1 gene to outside databases

Previous GC identifers: GC14P065332 GC14P061620 GC14P065817 GC14P066896 GC14P047996


Summaries
for EIF2S1 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for EIF2S1:
The translation initiation factor EIF2 catalyzes the first regulated step of protein synthesis initiation, promoting
the binding of the initiator tRNA to 40S ribosomal subunits. Binding occurs as a ternary complex of methionyl-tRNA,
EIF2, and GTP. EIF2 is composed of 3 nonidentical subunits, the 36-kD EIF2-alpha subunit (EIF2S1), the 38-kD EIF2-beta
subunit (EIF2S2; MIM 603908), and the 52-kD EIF2-gamma subunit (EIF2S3; MIM 300161). The rate of formation of the
ternary complex is modulated by the phosphorylation state of EIF2-alpha (Ernst et al., 1987 (PubMed
2948954)).(supplied by OMIM, Feb 2010)

UniProtKB/Swiss-Prot: IF2A_HUMAN, P05198
Function: Functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA.
This complex binds to a 40S ribosomal subunit, followed by mRNA binding to form a 43S preinitiation complex. Junction
of the 60S ribosomal subunit to form the 80S initiation complex is preceded by hydrolysis of the GTP bound to eIF-2
and release of an eIF-2-GDP binary complex. In order for eIF-2 to recycle and catalyze another round of initiation,
the GDP bound to eIF-2 must exchange with GTP by way of a reaction catalyzed by eIF-2B

summary for EIF2S1:
Eukaryotic translation initiation factor 2A (eIF2A) is involved in the first step of the initiation of
protein synthesis. It forms a complex with GTP and initiator tRNA. EIF2 is composed of three subunits,
namely EIF2-alpha (EIF2S1), EIF2-beta (EIF2S2) and EIF2-gamma (EIF2S3).

Gene Wiki entry for EIF2S1


Genomic Views
for EIF2S1 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000014.8  NC_018925.1  NT_026437.12  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the EIF2S1 gene promoter:
         STAT1   AP-1   p53   ATF-2   STAT1beta   IRF-1   C/EBPalpha   PPAR-gamma1   c-Jun   PPAR-gamma2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: EIF2S1 promoter sequence
   Search SABiosciences Chromatin IP Primers for EIF2S1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat EIF2S1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 14q23.3   Ensembl cytogenetic band:  14q23.3   HGNC cytogenetic band: 14q21.3

EIF2S1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
EIF2S1 gene location

GeneLoc information about chromosome 14         GeneLoc Exon Structure

GeneLoc location for GC14P067826:  view genomic region     (about GC identifiers)

Start:
 67,826,714 bp from pter      End:
 67,853,233 bp from pter
Size:
 26,520 bases      Orientation:
 plus strand

Proteins
for EIF2S1 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: IF2A_HUMAN, P05198 (See protein sequence)
Recommended Name: Eukaryotic translation initiation factor 2 subunit 1  
Size: 315 amino acids; 36112 Da
Subunit: Heterotrimer composed of an alpha, a beta and a gamma chain. Component of an EIF2 complex at least composed of
CELF1/CUGBP1, CALR, CALR3, EIF2S1, EIF2S2, HSP90B1 and HSPA5. Interaction with METAP2 protects EIF2S1 from inhibitory
phosphorylation (By similarity). Interacts with ABCF1 isoform 2. Associates with ribosomes
Subcellular location: Cytoplasmic granule (By similarity). Note=The cytoplasmic granules are stress granules which are
a dense aggregation in the cytosol composed of proteins and RNAs that appear when the cell is under stress.
Co-localizes with NANOS3 in the stress granules (By similarity)
2 PDB 3D structures from and Proteopedia for EIF2S1:
1KL9 (3D)        1Q8K (3D)    

Explore the universe of human proteins at neXtProt for EIF2S1: NX_P05198

Post-translational modifications:

  • Substrate for at least 4 kinases: EIF2AK3/PERK, GCN2, HRI and PKR. Phosphorylation stabilizes the eIF-2/GDP/eIF-2B
    • complex and prevents GDP/GTP exchange reaction, thus impairing the recycling of eIF-2 between successive rounds of
    initiation and leading to global inhibition of translation. In case of infection by vaccinia virus or rotavirus A,
    eIF2S1 phosphorylation state is modulated1
  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_P05198

    • EIF2S1 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_004085.1  
    ENSEMBL proteins: 
     ENSP00000256383   ENSP00000451975   ENSP00000425299   ENSP00000452034  
    Reactome Protein details: P05198
    Human Recombinant Protein Products: 
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    OriGene Custom Protein Services for EIF2S1 
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    Novus Biologicals EIF2S1 Proteins
    Novus Biologicals EIF2S1 Lysate
    Browse Sino Biological Recombinant Proteins
    ProSpec Recombinant Protein for EIF2S1
    Uscn Proteins for EIF2S1

    Gene Ontology (GO): 5/7 cellular component terms (GO ID links to tree view) (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IEA--
    GO:0005737cytoplasm ----
    GO:0005829cytosol TAS--
    GO:0005844polysome TAS2948954
    GO:0005850eukaryotic translation initiation factor 2 complex IEA--


    EIF2S1 for ontologies           About GeneDecksing



    EIF2S1 Antibody Products: 
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    Abcam antibodies for EIF2S1 
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    ThermoFisher Antibodies for EIF2S1

    Assay Products for EIF2S1: 
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    Uscn ELISAs and CLIAs for EIF2S1

    Protein Domains /
    Families
    for EIF2S1 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    EIF2S1 for domains           About GeneDecksing

    5/6 InterPro domains/families (see all 6):
     IPR012340 NA-bd_OB-fold
     IPR003029 Rbsml_prot_S1_RNA-bd_dom
     IPR011488 TIF_2_asu
     IPR024055 TIF2_asu_C
     IPR024054 TIF2_asu_middle

    Graphical View of Domain Structure for InterPro Entry P05198

    ProtoNet protein and cluster: P05198

    2 Blocks protein families:
    IPB003029 RNA binding S1
    IPB011488 Eukaryotic translation initiation factor 2


    UniProtKB/Swiss-Prot: IF2A_HUMAN, P05198
    Similarity: Belongs to the eIF-2-alpha family
    Similarity: Contains 1 S1 motif domain


    Function
    for EIF2S1 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: IF2A_HUMAN, P05198
    Function: Functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA.
    This complex binds to a 40S ribosomal subunit, followed by mRNA binding to form a 43S preinitiation complex. Junction
    of the 60S ribosomal subunit to form the 80S initiation complex is preceded by hydrolysis of the GTP bound to eIF-2
    and release of an eIF-2-GDP binary complex. In order for eIF-2 to recycle and catalyze another round of initiation,
    the GDP bound to eIF-2 must exchange with GTP by way of a reaction catalyzed by eIF-2B

    miRNA
    Products:            		miRTarBase miRNAs that target EIF2S1:
    hsa-mir-21 (MIRT004813)

    OriGene 3'-UTR Clone: EIF2S1
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat EIF2S1
    8/82 QIAGEN miScript miRNA Assays for microRNAs that regulate EIF2S1 (see all 82):
    hsa-miR-124* hsa-miR-582-3p hsa-miR-520e hsa-miR-520f hsa-miR-1260b hsa-miR-3622b-3p hsa-miR-1243 hsa-miR-556-3p
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
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    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for EIF2S1 (see all 7)
    OriGene shRNA RFP: EIF2S1
    OriGene siRNA: EIF2S1
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat EIF2S1

    Gene Editing
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    Clone
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    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for EIF2S1 (see all 3)
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    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector: EIF2S1 (NM_004094)
    Browse Sino Biological Human cDNA Clones
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat EIF2S1 

    Cell Line
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    Search LifeMap BioReagents cell lines for EIF2S1

    In Situ Assay
    Products:       
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for EIF2S1

    Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003743translation initiation factor activity IDA16289705
    GO:0005515protein binding IPI--
    GO:0043022ribosome binding IDA17894550


    EIF2S1 for ontologies           About GeneDecksing


    3 GenomeRNAi human phenotypes for EIF2S1:
     Decreased influenza A virus in  Decreased viability of wild-ty  Increased gamma-H2AX phosphory 

    Animal Models:
         6 MGI mutant phenotypes (inferred from 1 allele) (MGI details for Eif2s1):
     behavior/neurological  endocrine/exocrine gland  growth/size  hematopoietic system  homeostasis/metabolism 
     mortality/aging 

    EIF2S1 for phenotypes           About GeneDecksing


    Pathways & Interactions
    for EIF2S1 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways - 5/19 super-pathways (see all 19) About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Synthesis of PB1-F2
    		3' -UTR-mediated translational regulation0.79
    		Eukaryotic Translation Initiation0.73
    		L13a-mediated translational silencing of Ceruloplasmin expression0.79
    		Cap-dependent Translation Initiation0.73
    		GTP hydrolysis and joining of the 60S ribosomal subunit0.78
    		Translation0.57
    2Translation initiation complex formation
    		Translation initiation complex formation1.00
    		Ribosomal scanning and start codon recognition0.96
    		Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S0.98
    		Formation of the ternary complex, and subsequently, the 43S complex0.87
    3Development_CNTF receptor signaling
    		Translation_Insulin regulation of translation0.35
    		Translation _Regulation of EIF2 activity0.25
    		Translation Insulin regulation of translation0.35
    		Translation Regulation activity of EIF20.25
    4Measles
    		Measles1.00
    		Influenza A0.35
    5Recycling of eIF2:GDP
    		Recycling of eIF2:GDP1.00

    Pathway sources
    See GeneCards unified pathways
    Show all pathways

    2 EMD Millipore Pathways for EIF2S1
        Translation Insulin regulation of translation
    Translation Regulation activity of EIF2

    4 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for EIF2S1
        GSK3 Signaling
    PKR Pathway
    Activation of NF-KappaB by PKR
    eIF2 Pathway

    1 Cell Signaling Technology (CST) Pathway for EIF2S1
        Translational Control

    2 GeneGo (Thomson Reuters) Pathways for EIF2S1
        Translation Insulin regulation of translation
    Translation Regulation of EIF2 activity

    2 BioSystems Pathways for EIF2S1 
        Translation Factors
    Validated targets of C-MYC transcriptional activation

    5/15        Reactome Pathways for EIF2S1 (see all 15)
        Formation of the ternary complex, and subsequently, the 43S complex
    Translation
    GTP hydrolysis and joining of the 60S ribosomal subunit
    Eukaryotic Translation Initiation
    Ribosomal scanning and start codon recognition


    5         Kegg Pathways  (Kegg details for EIF2S1):
        RNA transport
    Protein processing in endoplasmic reticulum
    Hepatitis C
    Measles
    Influenza A


    EIF2S1 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for EIF2S1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/752 Interacting proteins for EIF2S1 (P051981, 2, 3 ENSP000002563834) via UniProtKB, MINT, STRING, and/or I2D (see all 752)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    HIST1H4AP628053I2D: score=1 
    HIST1H4BP628053I2D: score=1 
    HIST1H4CP628053I2D: score=1 
    HIST1H4DP628053I2D: score=1 
    HIST1H4EP628053I2D: score=1 
    About this table

    Gene Ontology (GO): 5/8 biological process terms (GO ID links to tree view) (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006412translation TAS--
    GO:0006413translational initiation TAS--
    GO:0006987activation of signaling protein activity involved in unfolded protein response TAS--
    GO:0010467gene expression TAS--
    GO:0030968endoplasmic reticulum unfolded protein response TAS--


    EIF2S1 for ontologies           About GeneDecksing



    Drugs & Compounds
    for EIF2S1 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    EIF2S1 for compounds           About GeneDecksing

    EMD Millipore small molecules for EIF2S1:
    Small Molecule - inhibitor
    Browse drugs & compounds from Enzo Life Sciences

    Compounds for EIF2S1 available from Tocris Bioscience    About this table
    CompoundAction CAS #
    SalubrinalSelective inhibitor of eIF2alpha dephosphorylation[405060-95-9]
    Sal 003Cell-permeable inhibitor of eIR2alpha dephosphorylation[1164470-53-4]

    1 HMDB Compound for EIF2S1    About this table
    CompoundSynonyms CAS #PubMed Ids
    Guanosine triphosphate5'-GTP (see all 10)86-01-1--
    10/49 Novoseek chemical compound relationships for EIF2S1 gene (see all 49)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    tunicamycin 71.8 10 17438523 (2), 19100962 (1), 19007793 (1), 19193809 (1) (see all 6)
    thapsigargin 60.6 10 20022965 (2), 19100962 (1), 19193809 (1), 19835916 (1)
    pactamycin 58.4 1 8619603 (1)
    polyinosinic-polycytidylic acid 55.5 4 10400313 (1), 10432301 (1), 10823866 (1), 12590973 (1)
    rapamycin 51.2 6 16483933 (1), 14726531 (1), 17331981 (1), 18219697 (1) (see all 5)
    arsenite 50.6 9 15788408 (2), 9867869 (1), 11809833 (1), 19878647 (1) (see all 7)
    threonine 48 9 10400313 (1), 11956076 (1), 17998206 (1), 12975376 (1) (see all 8)
    bortezomib 42.9 6 20022965 (2), 16357160 (2)
    gdp 42.1 17 2076109 (3), 20485439 (2), 7918624 (2), 10734073 (1) (see all 7)
    cycloheximide 40.7 9 9867869 (3), 14690445 (2), 20171949 (1), 17082262 (1) (see all 6)

    Search CenterWatch for drugs/clinical trials and news about EIF2S1 / IF2A 

    Transcripts
    for EIF2S1 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for EIF2S1 gene: 
    NM_004094.4  

    Unigene Cluster for EIF2S1:

    Eukaryotic translation initiation factor 2, subunit 1 alpha, 35kDa
    Hs.151777  [show with all ESTs]
    Unigene Representative Sequence: NM_004094
    6 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000256383(uc001xjg.3) ENST00000556724 ENST00000557310 ENST00000466499
    ENST00000555876 ENST00000554332

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    hsa-miR-124* hsa-miR-582-3p hsa-miR-520e hsa-miR-520f hsa-miR-1260b hsa-miR-3622b-3p hsa-miR-1243 hsa-miR-556-3p
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    Clone
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    GenScript: all cDNA clones in your preferred vector: EIF2S1 (NM_004094)
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat EIF2S1 
    Primer
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat EIF2S1
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    Additional cDNA sequence: 

    AK297244.1 AK312442.1 BC002513.2 BX161521.1 D28379.1 J02645.1 U26032.1 

    24/26 DOTS entries (see all 26):

    DT.95164142  DT.117457  DT.100858713  DT.100858715  DT.95164146  DT.117456  DT.100858707  DT.100858709 
    DT.100728945  DT.120743165  DT.100763086  DT.100834711  DT.120743250  DT.120743254  DT.120743298  DT.120743299 
    DT.87016005  DT.91698754  DT.95164140  DT.95201784  DT.95201793  DT.99981843  DT.100044784  DT.100717904 

    24/549 AceView cDNA sequences (see all 549):

    J02645 BX408549 AA832194 BU686298 AI499926 AI763340 BU624131 CR604321 
    BP382556 CA420892 BU684992 NM_004094 CR601355 BM663967 BM696938 AU117835 
    CR600389 AA082714 CD364608 AI671471 H65202 CA429584 BQ063181 BM755414 

    GeneLoc Exon Structure


    Expression
    for EIF2S1 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    EIF2S1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: AAATGCCCTC

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image
    See EIF2S1 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for EIF2S1

    SOURCE GeneReport for Unigene cluster: Hs.151777
        SABiosciences Custom PCR Arrays for EIF2S1
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    Orthologs
    for EIF2S1 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of eukaryotes.

    Orthologs for EIF2S1 gene from 10/38 species (see all 38)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    mouse
    (Mus musculus)    		 Mammalia Eif2s11 , 5 eukaryotic translation initiation factor 2, subunit more1, 5 93.33(n)1
    99.05(a)1    		   12 (35.51 cM)5
    136651  NM_026114.31  NP_080390.11 
     788618195 
    chicken
    (Gallus gallus)    		 Aves EIF2S11 eukaryotic translation initiation factor 2, subunit more 84.95(n)
    97.57(a)    		   423279  NM_001006477.1  NP_001006477.1 
    lizard
    (Anolis carolinensis)    		 Reptilia EIF2S16
    		 --
    		 97(a)
    		 1 ↔ 1
    		 GL343272.1(1210154-1220288)
    African clawed frog
    (Xenopus laevis)    		 Amphibia eif2s1-prov2 eukaryotic translation initiation factor 2, subunit more 81(n)    BC046576.1 
    zebrafish
    (Danio rerio)    		 Actinopterygii BC049468.12   -- 79.19(n)   321807  BC049468.1 
    fruit fly
    (Drosophila melanogaster)    		 Insecta eIF-2alpha1 , 3 translational initiation translation
    initiation more3
    eukaryotic translation Initiation Factor 2alpha1    		 62(a)3
    58.22(n)1
    62.5(a)1    		   14C63
    326171  NM_132902.31  NP_573130.11 
    worm
    (Caenorhabditis elegans)    		 Secernentea Y37E3.101 , 3 Protein Y37E3.101 58(a)3
    60.54(n)1
    57.53(a)1    		   I(2072691-2076102)3
    1717691  NM_058529.21  NP_490930.11 
    baker's yeast
    (Saccharomyces cerevisiae)    		 Saccharomycetes SUI2(YJR007W)4
    SUI21    		 Alpha subunit of the translation initiation factor more4
    Sui2p1    		 61.49(n)1
    55.07(a)1    		   10(451020-451934)4
    8534631, 4  NP_012540.31  NP_012540.14 
    thale cress
    (Arabidopsis thaliana)    		 eudicotyledons AT2G402901 Eukaryotic translation initiation factor 2 subunit more 56.15(n)
    51.16(a)    		   818621  NM_129587.2  NP_565927.1 
    rice
    (Oryza sativa)    		 Liliopsida Os.116462 Oryza sativa (japonica cultivar-group) cDNA clone0 more 68.86(n)    AK104149.1 


    ENSEMBL Gene Tree for EIF2S1 (if available)
    TreeFam Gene Tree for EIF2S1 (if available) 

    Paralogs
    for EIF2S1 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    		  --

    Genomic Variants
    for EIF2S1 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/475 NCBI SNPs in EIF2S1 are shown (see all 475)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 14 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs1903754851,2
    		--67825040(+) AAGGTA/TAAAAA 2 -- int1 us2k10--------
    rs1405795971,2
    		--67825069(+) TTAAGA/GGCTAT 2 -- int1 us2k10--------
    rs1817303021,2
    		--67825071(+) AAGAGC/GTATTT 2 -- int1 us2k10--------
    rs1169571331,2
    		F,--67825097(+) AGAAAT/CCTGGG 2 -- us2k1 int11Minor allele frequency- C:0.03NA 120
    rs1861303961,2
    		--67825212(+) AAAGGA/GTCTAA 2 -- us2k1 int10--------
    rs1470920751,2
    		--67825223(+) ATGTCA/GGGGTC 2 -- us2k1 int10--------
    rs727174011,2
    		F,--67825398(+) GGAGAC/ACCTGT 2 -- int1 us2k12Minor allele frequency- A:0.05NA EA 240
    rs1888974701,2
    		--67825469(+) GGGAGA/CAAGTT 2 -- int1 us2k10--------
    rs727174021,2
    		--67825580(+) AAAGGC/TAGCCC 2 -- us2k1 int10--------
    rs1813553811,2
    		--67825596(+) TGAGCA/GTATTC 2 -- int1 us2k10--------

    HapMap Linkage Disequilibrium report for EIF2S1 (67826714 - 67853233 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 1 variation for EIF2S1
         1 CNV: 8772

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    Disorders / Diseases
    for EIF2S1 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    EIF2S1 for disorders           About GeneDecksing

    OMIM gene information: 603907    OMIM disorders: --

    20/51 diseases for EIF2S1 (see all 51):    About MalaCards
    wolcott-rallison syndrome    temporal lobe epilepsy    severe acute respiratory syndrome    polycythemia vera
    herpes simplex    brain ischemia    fatty liver disease    newcastle disease
    polycythemia    neurodegenerative disease    hepatitis c    cowpox
    stomatitis    ulcerative colitis    neuroectodermal tumors    ischemia
    myxoma    liver disease    squamous cell carcinoma    hodgkin's lymphoma

    1 disease from the University of Copenhagen DISEASES database for EIF2S1:
    Brain ischemia

    10/24 Novoseek disease relationships for EIF2S1 gene (see all 24)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    wolcott-rallison syndrome 70.5 1 12475790 (1)
    virus infection 45 17 19131336 (1), 15060162 (1), 15705855 (1), 19043413 (1) (see all 11)
    cancer 32.8 14 18087277 (3), 15456240 (1), 17531337 (1), 19190324 (1) (see all 5)
    brain ischemia 28.8 3 17288737 (3)
    herpes simplex 28.3 9 9696792 (2), 9023344 (1), 11070019 (1), 15705855 (1) (see all 8)
    shock 24.9 9 16505970 (2), 11689689 (2), 19936221 (1), 7930798 (1) (see all 5)
    tumors 20 14 16472113 (2), 18007663 (1), 19716858 (1), 17113348 (1) (see all 9)
    neurodegenerative diseases 17.6 1 11238455 (1)
    leukemia 11.5 3 20110807 (1), 17548474 (1)
    alzheimers disease 10.4 5 12445160 (1), 12975376 (1), 19017641 (1), 12499843 (1)

    Genetic Association Database (GAD): EIF2S1
    Human Genome Epidemiology (HuGE) Navigator: EIF2S1 (2 documents)

    Export disorders for EIF2S1 gene to outside databases

    Publications
    for EIF2S1 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for EIF2S1 gene, integrated from 9 sources (see all 507):
    (articles sorted by number of sources associating them with EIF2S1)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Cloning and sequencing of complementary DNAs encoding the alpha- subunit of translational initiation factor eIF-2. Characterization of the protein and its messenger RNA. (PubMed id 2948954)1, 2, 3 Ernst H.... Hershey J.W.B. (1987)
    2. Solution structure of human initiation factor eIF2alpha reveals homology to the elongation factor eEF1B. (PubMed id 15341733)1, 2, 9 Ito T.... Wagner G. (2004)
    3. The N-terminal region of ABC50 interacts with eukaryotic initiation factor eIF2 and is a target for regulatory phosphorylation by CK2. (PubMed id 17894550)1, 2 Paytubi S....Proud C.G. (2008)
    4. Inhibition of PKR by vaccinia virus: role of the N- and C-terminal domains of E3L. (PubMed id 15207627)1, 2 Langland J.O. and Jacobs B.L. (2004)
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    6. Crystal structure of the N-terminal segment of human eukaryotic translation initiation factor 2alpha. (PubMed id 11859078)1, 2 Nonato M.C.... Clardy J. (2002)
    7. Genetic polymorphisms in interferon pathway and response to interferon treatment in hepatitis B patients: A pilot study. (PubMed id 12447867)1, 4 King J.K....Chen P.J. (2002)
    8. Phosphorylation of eukaryotic initiation factor-2alpha (eIF2alpha) is associated with neuronal degeneration in Alzheimer's disease. (PubMed id 12499843)1, 9 Chang R.C....Hugon J. (2002)
    9. Identification of caspase 3-mediated cleavage and functional alteration of eukaryotic initiation factor 2alpha in apoptosis. (PubMed id 10734073)1, 9 Marissen W.E....Lloyd R.E. (2000)
    10. Inhibition of eIF2alpha dephosphorylation inhibits Er bB2-induced deregulation of mammary acinar morphogenesis. (PubMed id 19754954)1, 9 Sequeira S.J....Aguirre-Ghiso J.A. (2009)

    External Searches for EIF2S1 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing EIF2S1 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 1965 HGNC: 3265 AceView: EIF2S1 Ensembl:ENSG00000134001 euGenes: HUgn1965
    ECgene: EIF2S1 Kegg: 1965 H-InvDB: EIF2S1

    Other Databases showing EIF2S1 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing EIF2S1 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for EIF2S1 Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for EIF2S1 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for EIF2S1 gene:
    Search GeneIP for patents involving EIF2S1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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