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Aliases for EIF2S1 Gene

Aliases for EIF2S1 Gene

  • Eukaryotic Translation Initiation Factor 2, Subunit 1 Alpha, 35kDa 2 3
  • Eukaryotic Translation Initiation Factor 2 Subunit Alpha 3 4
  • EIF-2-Alpha 3 4
  • EIF-2alpha 3 4
  • EIF-2A 3 4
  • EIF2A 3 4
  • Eukaryotic Translation Initiation Factor 2, Subunit 1 (Alpha, 35kD ) 2
  • Eukaryotic Translation Initiation Factor 2 Subunit 1 3
  • EIF-2 3
  • EIF2 3

External Ids for EIF2S1 Gene

Previous Symbols for EIF2S1 Gene

  • EIF2

Summaries for EIF2S1 Gene

Entrez Gene Summary for EIF2S1 Gene

  • The translation initiation factor EIF2 catalyzes the first regulated step of protein synthesis initiation, promoting the binding of the initiator tRNA to 40S ribosomal subunits. Binding occurs as a ternary complex of methionyl-tRNA, EIF2, and GTP. EIF2 is composed of 3 nonidentical subunits, the 36-kD EIF2-alpha subunit (EIF2S1), the 38-kD EIF2-beta subunit (EIF2S2; MIM 603908), and the 52-kD EIF2-gamma subunit (EIF2S3; MIM 300161). The rate of formation of the ternary complex is modulated by the phosphorylation state of EIF2-alpha (Ernst et al., 1987 [PubMed 2948954]).[supplied by OMIM, Feb 2010]

GeneCards Summary for EIF2S1 Gene

EIF2S1 (Eukaryotic Translation Initiation Factor 2, Subunit 1 Alpha, 35kDa) is a Protein Coding gene. Diseases associated with EIF2S1 include wolcott-rallison syndrome. Among its related pathways are Apoptotic Pathways in Synovial Fibroblasts and Nanog in Mammalian ESC Pluripotency. GO annotations related to this gene include translation initiation factor activity and ribosome binding.

UniProtKB/Swiss-Prot for EIF2S1 Gene

  • Functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA. This complex binds to a 40S ribosomal subunit, followed by mRNA binding to form a 43S preinitiation complex. Junction of the 60S ribosomal subunit to form the 80S initiation complex is preceded by hydrolysis of the GTP bound to eIF-2 and release of an eIF-2-GDP binary complex. In order for eIF-2 to recycle and catalyze another round of initiation, the GDP bound to eIF-2 must exchange with GTP by way of a reaction catalyzed by eIF-2B

Tocris Summary for EIF2S1 Gene

  • Eukaryotic translation initiation factor 2A (eIF2A) is involved in the first step of the initiation of protein synthesis. It forms a complex with GTP and initiator tRNA. EIF2 is composed of three subunits, namely EIF2-alpha (EIF2S1), EIF2-beta (EIF2S2) and EIF2-gamma (EIF2S3).

Gene Wiki entry for EIF2S1 Gene

No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for EIF2S1 Gene

Genomics for EIF2S1 Gene

Genomic Location for EIF2S1 Gene

Start:
67,359,997 bp from pter
End:
67,386,516 bp from pter
Size:
26,520 bases
Orientation:
Plus strand

Genomic View for EIF2S1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for EIF2S1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for EIF2S1 Gene

Regulatory Elements for EIF2S1 Gene

Proteins for EIF2S1 Gene

  • Protein details for EIF2S1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P05198-IF2A_HUMAN
    Recommended name:
    Eukaryotic translation initiation factor 2 subunit 1
    Protein Accession:
    P05198
    Secondary Accessions:

    Protein attributes for EIF2S1 Gene

    Size:
    315 amino acids
    Molecular mass:
    36112 Da
    Quaternary structure:
    • Heterotrimer composed of an alpha, a beta and a gamma chain. Component of an EIF2 complex at least composed of CELF1/CUGBP1, CALR, CALR3, EIF2S1, EIF2S2, HSP90B1 and HSPA5. Interaction with METAP2 protects EIF2S1 from inhibitory phosphorylation (By similarity). Interacts with ABCF1 isoform 2. Associates with ribosomes.

    Three dimensional structures from OCA and Proteopedia for EIF2S1 Gene

neXtProt entry for EIF2S1 Gene

Proteomics data for EIF2S1 Gene at MOPED

Post-translational modifications for EIF2S1 Gene

  • Substrate for at least 4 kinases: EIF2AK3/PERK, GCN2, HRI and PKR. Phosphorylation stabilizes the eIF-2/GDP/eIF-2B complex and prevents GDP/GTP exchange reaction, thus impairing the recycling of eIF-2 between successive rounds of initiation and leading to global inhibition of translation. In case of infection by vaccinia virus or rotavirus A, eIF2S1 phosphorylation state is modulated.
  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys101, Lys106, Lys123, Lys141, Lys143, Lys190, Lys209, Lys226, and Lys259

Other Protein References for EIF2S1 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for EIF2S1 Gene

Domains for EIF2S1 Gene

UniProtKB/Swiss-Prot:

IF2A_HUMAN
Domain:
  • Contains 1 S1 motif domain.:
    • P05198
Family:
  • Belongs to the eIF-2-alpha family.:
    • P05198
genes like me logo Genes that share domains with EIF2S1: view

No data available for Gene Families for EIF2S1 Gene

Function for EIF2S1 Gene

Molecular function for EIF2S1 Gene

UniProtKB/Swiss-Prot Function: Functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA. This complex binds to a 40S ribosomal subunit, followed by mRNA binding to form a 43S preinitiation complex. Junction of the 60S ribosomal subunit to form the 80S initiation complex is preceded by hydrolysis of the GTP bound to eIF-2 and release of an eIF-2-GDP binary complex. In order for eIF-2 to recycle and catalyze another round of initiation, the GDP bound to eIF-2 must exchange with GTP by way of a reaction catalyzed by eIF-2B

Gene Ontology (GO) - Molecular Function for EIF2S1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003676 nucleic acid binding --
GO:0003723 RNA binding --
GO:0003743 translation initiation factor activity IDA 16289705
GO:0005515 protein binding IPI 11500362
GO:0043022 ribosome binding IDA 17894550
genes like me logo Genes that share ontologies with EIF2S1: view
genes like me logo Genes that share phenotypes with EIF2S1: view

miRNA for EIF2S1 Gene

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for EIF2S1 Gene

Localization for EIF2S1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for EIF2S1 Gene

Cytoplasmic granule. Note=The cytoplasmic granules are stress granules which are a dense aggregation in the cytosol composed of proteins and RNAs that appear when the cell is under stress. Colocalizes with NANOS3 in the stress granules (By similarity). {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for EIF2S1 Gene COMPARTMENTS Subcellular localization image for EIF2S1 gene
Compartment Confidence
cytosol 4
endoplasmic reticulum 3
nucleus 2
peroxisome 2
extracellular 1
mitochondrion 1
vacuole 1

Gene Ontology (GO) - Cellular Components for EIF2S1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005737 cytoplasm --
GO:0005829 cytosol TAS --
GO:0005840 ribosome IBA --
GO:0005844 polysome TAS 2948954
genes like me logo Genes that share ontologies with EIF2S1: view

Pathways for EIF2S1 Gene

genes like me logo Genes that share pathways with EIF2S1: view

Gene Ontology (GO) - Biological Process for EIF2S1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002230 positive regulation of defense response to virus by host IMP 22020285
GO:0006412 translation TAS --
GO:0006413 translational initiation TAS --
GO:0006987 activation of signaling protein activity involved in unfolded protein response --
GO:0010467 gene expression TAS --
genes like me logo Genes that share ontologies with EIF2S1: view

Compounds for EIF2S1 Gene

(5) Tocris Compounds for EIF2S1 Gene

Compound Action Cas Number
Calyculin A Protein phosphatase 1 and 2A inhibitor [101932-71-2]
Cyclosporin A Calcineurin inhibitor [59865-13-3]
FK 506 Potent calcineurin inhibitor; immunosuppressant [104987-11-3]
Okadaic acid Protein phosphatase 1 and 2A inhibitor [78111-17-8]
Salubrinal Selective inhibitor of eIF2alpha dephosphorylation [405060-95-9]

(1) HMDB Compounds for EIF2S1 Gene

Compound Synonyms Cas Number PubMed IDs
Guanosine triphosphate
  • 5'-GTP
86-01-1

(49) Novoseek inferred chemical compound relationships for EIF2S1 Gene

Compound -log(P) Hits PubMed IDs
tunicamycin 71.8 7
thapsigargin 60.6 5
pactamycin 58.4 1
polyinosinic-polycytidylic acid 55.5 4
rapamycin 51.2 5
genes like me logo Genes that share compounds with EIF2S1: view

Transcripts for EIF2S1 Gene

Unigene Clusters for EIF2S1 Gene

Eukaryotic translation initiation factor 2, subunit 1 alpha, 35kDa:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for EIF2S1 Gene

No ASD Table

Relevant External Links for EIF2S1 Gene

GeneLoc Exon Structure for
EIF2S1
ECgene alternative splicing isoforms for
EIF2S1

Expression for EIF2S1 Gene

mRNA expression in normal human tissues for EIF2S1 Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for EIF2S1 Gene

SOURCE GeneReport for Unigene cluster for EIF2S1 Gene Hs.151777

genes like me logo Genes that share expressions with EIF2S1: view

Orthologs for EIF2S1 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for EIF2S1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia EIF2S1 36
  • 99.79 (n)
  • 100 (a)
EIF2S1 37
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia EIF2S1 36
  • 94.81 (n)
  • 99.05 (a)
EIF2S1 37
  • 99 (a)
OneToOne
dog
(Canis familiaris)
Mammalia EIF2S1 36
  • 94.81 (n)
  • 99.05 (a)
EIF2S1 37
  • 99 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Eif2s1 36
  • 93.33 (n)
  • 99.05 (a)
Eif2s1 16
Eif2s1 37
  • 99 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia EIF2S1 37
  • 98 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia EIF2S1 37
  • 98 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Eif2s1 36
  • 93.33 (n)
  • 99.05 (a)
chicken
(Gallus gallus)
Aves EIF2S1 36
  • 84.95 (n)
  • 97.57 (a)
EIF2S1 37
  • 97 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia EIF2S1 37
  • 97 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia eif2s1-prov 36
tropical clawed frog
(Silurana tropicalis)
Amphibia eif2s1 36
  • 81.27 (n)
  • 93.65 (a)
Str.6631 36
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.7988 36
zebrafish
(Danio rerio)
Actinopterygii -- 36
eif2s1a 37
  • 94 (a)
OneToMany
eif2s1b 36
  • 77.25 (n)
  • 94.29 (a)
eif2s1b 37
  • 94 (a)
OneToMany
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP011190 36
  • 61.11 (n)
  • 68 (a)
fruit fly
(Drosophila melanogaster)
Insecta eIF-2alpha 36
  • 58.14 (n)
  • 62.3 (a)
eIF-2alpha 37
  • 57 (a)
OneToOne
eIF-2alpha 38
  • 62 (a)
worm
(Caenorhabditis elegans)
Secernentea Y37E3.10 36
  • 60.77 (n)
  • 58.5 (a)
Y37E3.10 37
  • 51 (a)
OneToOne
Y37E3.10 38
  • 58 (a)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AGR320W 36
  • 57.97 (n)
  • 55.85 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes SUI2 36
  • 61.32 (n)
  • 54.85 (a)
SUI2 37
  • 54 (a)
OneToOne
SUI2 39
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0A11814g 36
  • 60.31 (n)
  • 57.53 (a)
Alicante grape
(Vitis vinifera)
eudicotyledons Vvi.7752 36
thale cress
(Arabidopsis thaliana)
eudicotyledons AT2G40290 36
  • 56.12 (n)
  • 51.52 (a)
corn
(Zea mays)
Liliopsida Zm.4283 36
rice
(Oryza sativa)
Liliopsida Os.11646 36
Os07g0692800 36
  • 54.78 (n)
  • 54.33 (a)
bread mold
(Neurospora crassa)
Ascomycetes NCU08277 36
  • 55.63 (n)
  • 54.39 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes tif211 36
  • 59.82 (n)
  • 56.23 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.1492 36
Species with no ortholog for EIF2S1:
  • Actinobacteria (Mycobacterium tuberculosis)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for EIF2S1 Gene

ENSEMBL:
Gene Tree for EIF2S1 (if available)
TreeFam:
Gene Tree for EIF2S1 (if available)

Paralogs for EIF2S1 Gene

No data available for Paralogs for EIF2S1 Gene

Variants for EIF2S1 Gene

Sequence variations from dbSNP and Humsavar for EIF2S1 Gene

SNP ID Clin Chr 14 pos Sequence Context AA Info Type MAF
rs3248 -- 67,385,226(-) CCTCA(C/T)ATGTA utr-variant-3-prime
rs13595 -- 67,385,905(-) AGTAT(A/G)GCAGC utr-variant-3-prime
rs1803529 -- 67,382,485(+) ACTAC(G/T)ACAAC reference, synonymous-codon
rs1980817 -- 67,385,454(+) AAAAA(A/C)AACCA utr-variant-3-prime
rs2094163 -- 67,370,237(+) TTAGG(A/G)CCATT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for EIF2S1 Gene

Variant ID Type Subtype PubMed ID
esv2751285 CNV Gain 17911159
nsv832821 CNV Gain 17160897
nsv456331 CNV Gain 19166990
nsv470651 CNV Gain 18288195
nsv509539 CNV Insertion 20534489

Relevant External Links for EIF2S1 Gene

HapMap Linkage Disequilibrium report
EIF2S1

Disorders for EIF2S1 Gene

(1) MalaCards Diseases for EIF2S1 Gene

Search for EIF2S1 Gene in MalaCards »

(1) University of Copenhagen DISEASES for EIF2S1 Gene

(24) Novoseek inferred disease relationships for EIF2S1 Gene

Disease -log(P) Hits PubMed IDs
wolcott-rallison syndrome 70.5 1
virus infection 45 11
cancer 32.8 7
brain ischemia 28.8 3
herpes simplex 28.3 9

Relevant External Links for EIF2S1

Genetic Association Database (GAD)
EIF2S1
Human Genome Epidemiology (HuGE) Navigator
EIF2S1
genes like me logo Genes that share disorders with EIF2S1: view

No data available for UniProtKB/Swiss-Prot for EIF2S1 Gene

Publications for EIF2S1 Gene

  1. Cloning and sequencing of complementary DNAs encoding the alpha- subunit of translational initiation factor eIF-2. Characterization of the protein and its messenger RNA. (PMID: 2948954) Ernst H. … Hershey J.W.B. (J. Biol. Chem. 1987) 2 3 4
  2. Viral host-range factor C7 or K1 is essential for modified vaccinia virus Ankara late gene expression in human and murine cells, irrespective of their capacity to inhibit protein kinase R-mediated phosphorylation of eukaryotic translation initiation factor 2alpha. (PMID: 19846675) Backes S. … Sutter G. (J. Gen. Virol. 2010) 3 23
  3. Sorafenib with doxorubicin augments cytotoxicity to renal cell cancer through PERK inhibition. (PMID: 20428777) Shiota M. … Naito S. (Int. J. Oncol. 2010) 3 23
  4. Recognition of 5'-terminal TAR structure in human immunodeficiency virus-1 mRNA by eukaryotic translation initiation factor 2. (PMID: 10648795) Ben-Asouli Y. … Kaempfer R. (Nucleic Acids Res. 2000) 3 23
  5. Phosphorylation of eukaryotic initiation factor-2alpha (eIF2alpha) is associated with neuronal degeneration in Alzheimer's disease. (PMID: 12499843) Chang R.C. … Hugon J. (Neuroreport 2002) 3 23

Products for EIF2S1 Gene

Sources for EIF2S1 Gene

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