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Aliases for EIF2D Gene

Aliases for EIF2D Gene

  • Eukaryotic Translation Initiation Factor 2D 2 3 5
  • Hepatocellular Carcinoma-Associated Antigen 56 3 4
  • Ligatin 3 4
  • HCA56 3 4
  • LGTN 3 4
  • EIF2d 4

External Ids for EIF2D Gene

Previous GeneCards Identifiers for EIF2D Gene

  • GC01M206745

Summaries for EIF2D Gene

Entrez Gene Summary for EIF2D Gene

  • This gene encodes a translation initiation factor involved in the recruitment and delivery of aminoacyl-tRNAs to the P-site of the eukaryotic ribosome in a GTP-independent manner. This gene was previously referred to as ligatin, but is now known to localize to the cytoplasm and localize and function with translation factors. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2011]

GeneCards Summary for EIF2D Gene

EIF2D (Eukaryotic Translation Initiation Factor 2D) is a Protein Coding gene. GO annotations related to this gene include RNA binding and translation initiation factor activity.

UniProtKB/Swiss-Prot for EIF2D Gene

  • Translation initiation factor that is able to deliver tRNA to the P-site of the eukaryotic ribosome in a GTP-independent manner. The binding of Met-tRNA(I) occurs after the AUG codon finds its position in the P-site of 40S ribosomes, the situation that takes place during initiation complex formation on some specific RNAs. Its activity in tRNA binding with 40S subunits does not require the presence of the aminoacyl moiety. Possesses the unique ability to deliver non-Met (elongator) tRNAs into the P-site of the 40S subunit. In addition to its role in initiation, can promote release of deacylated tRNA and mRNA from recycled 40S subunits following ABCE1-mediated dissociation of post-termination ribosomal complexes into subunits.

Gene Wiki entry for EIF2D Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for EIF2D Gene

Genomics for EIF2D Gene

Regulatory Elements for EIF2D Gene

Promoters for EIF2D Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around EIF2D on UCSC Golden Path with GeneCards custom track

Genomic Location for EIF2D Gene

Chromosome:
1
Start:
206,571,292 bp from pter
End:
206,612,551 bp from pter
Size:
41,260 bases
Orientation:
Minus strand

Genomic View for EIF2D Gene

Genes around EIF2D on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
EIF2D Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for EIF2D Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for EIF2D Gene

Proteins for EIF2D Gene

  • Protein details for EIF2D Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P41214-EIF2D_HUMAN
    Recommended name:
    Eukaryotic translation initiation factor 2D
    Protein Accession:
    P41214
    Secondary Accessions:
    • Q5SY40
    • Q8IXV3
    • Q96DG3
    • Q96TG7
    • Q9NR27
    • Q9NSN0
    • Q9NV18
    • Q9NZ21

    Protein attributes for EIF2D Gene

    Size:
    584 amino acids
    Molecular mass:
    64706 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for EIF2D Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for EIF2D Gene

Proteomics data for EIF2D Gene at MOPED

Post-translational modifications for EIF2D Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for EIF2D Gene

Antibody Products

No data available for DME Specific Peptides for EIF2D Gene

Domains & Families for EIF2D Gene

Protein Domains for EIF2D Gene

Suggested Antigen Peptide Sequences for EIF2D Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P41214

UniProtKB/Swiss-Prot:

EIF2D_HUMAN :
  • Contains 1 PUA domain.
  • Belongs to the eIF2D family.
Domain:
  • Contains 1 PUA domain.
  • Contains 1 SUI1 domain.
Family:
  • Belongs to the eIF2D family.
genes like me logo Genes that share domains with EIF2D: view

No data available for Gene Families for EIF2D Gene

Function for EIF2D Gene

Molecular function for EIF2D Gene

UniProtKB/Swiss-Prot Function:
Translation initiation factor that is able to deliver tRNA to the P-site of the eukaryotic ribosome in a GTP-independent manner. The binding of Met-tRNA(I) occurs after the AUG codon finds its position in the P-site of 40S ribosomes, the situation that takes place during initiation complex formation on some specific RNAs. Its activity in tRNA binding with 40S subunits does not require the presence of the aminoacyl moiety. Possesses the unique ability to deliver non-Met (elongator) tRNAs into the P-site of the 40S subunit. In addition to its role in initiation, can promote release of deacylated tRNA and mRNA from recycled 40S subunits following ABCE1-mediated dissociation of post-termination ribosomal complexes into subunits.

Gene Ontology (GO) - Molecular Function for EIF2D Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004872 receptor activity TAS 2482295
genes like me logo Genes that share ontologies with EIF2D: view
genes like me logo Genes that share phenotypes with EIF2D: view

Animal Model Products

miRNA for EIF2D Gene

miRTarBase miRNAs that target EIF2D

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for EIF2D Gene

Localization for EIF2D Gene

Subcellular locations from UniProtKB/Swiss-Prot for EIF2D Gene

Cytoplasm.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for EIF2D Gene COMPARTMENTS Subcellular localization image for EIF2D gene
Compartment Confidence
nucleus 4
cytosol 3

No data available for Gene Ontology (GO) - Cellular Components for EIF2D Gene

Pathways & Interactions for EIF2D Gene

SuperPathways for EIF2D Gene

No Data Available

Gene Ontology (GO) - Biological Process for EIF2D Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0032790 ribosome disassembly IDA 20713520
genes like me logo Genes that share ontologies with EIF2D: view

No data available for Pathways by source and SIGNOR curated interactions for EIF2D Gene

Drugs & Compounds for EIF2D Gene

(1) Drugs for EIF2D Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(1) Additional Compounds for EIF2D Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with EIF2D: view

Transcripts for EIF2D Gene

Unigene Clusters for EIF2D Gene

Eukaryotic translation initiation factor 2D:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for EIF2D Gene

ExUns: 1 ^ 2a · 2b · 2c · 2d ^ 3a · 3b ^ 4 ^ 5a · 5b · 5c ^ 6 ^ 7 ^ 8 ^ 9 ^ 10a · 10b ^ 11 ^ 12a · 12b ^ 13 ^ 14 ^ 15a · 15b ^ 16 ^ 17
SP1: - - - -
SP2: - - - - - -
SP3: - - - - - - -
SP4: - - -
SP5: - - - -
SP6: - - -
SP7: - - -
SP8:
SP9:

Relevant External Links for EIF2D Gene

GeneLoc Exon Structure for
EIF2D
ECgene alternative splicing isoforms for
EIF2D

Expression for EIF2D Gene

mRNA expression in normal human tissues for EIF2D Gene

Protein differential expression in normal tissues from HIPED for EIF2D Gene

This gene is overexpressed in Breast (24.6) and Esophagus (9.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for EIF2D Gene



SOURCE GeneReport for Unigene cluster for EIF2D Gene Hs.497581

genes like me logo Genes that share expression patterns with EIF2D: view

Protein tissue co-expression partners for EIF2D Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for EIF2D Gene

Orthologs for EIF2D Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for EIF2D Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia EIF2D 35
  • 89.06 (n)
  • 89.12 (a)
EIF2D 36
  • 89 (a)
OneToOne
dog
(Canis familiaris)
Mammalia EIF2D 35
  • 89.02 (n)
  • 87.8 (a)
EIF2D 36
  • 87 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Eif2d 35
  • 85.61 (n)
  • 82.81 (a)
Eif2d 16
Eif2d 36
  • 82 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia EIF2D 35
  • 99.6 (n)
  • 98.8 (a)
EIF2D 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Eif2d 35
  • 85.91 (n)
  • 83.16 (a)
oppossum
(Monodelphis domestica)
Mammalia EIF2D 36
  • 69 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia EIF2D 36
  • 59 (a)
OneToOne
chicken
(Gallus gallus)
Aves EIF2D 35
  • 66.9 (n)
  • 65.01 (a)
EIF2D 36
  • 62 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia EIF2D 36
  • 59 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia eif2d 35
  • 62.41 (n)
  • 61.54 (a)
MGC76058 35
zebrafish
(Danio rerio)
Actinopterygii eif2d 35
  • 60.71 (n)
  • 57.56 (a)
zgc63669 35
eif2d 36
  • 57 (a)
OneToOne
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.13929 35
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP011804 35
  • 45.57 (n)
  • 33.92 (a)
fruit fly
(Drosophila melanogaster)
Insecta ligatin 35
  • 47.88 (n)
  • 39.96 (a)
ligatin 36
  • 34 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea CELE_C25H3.4 35
  • 44.47 (n)
  • 32.45 (a)
C25H3.4 36
  • 30 (a)
OneToOne
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes TMA64 38
TMA64 36
  • 24 (a)
OneToOne
thale cress
(Arabidopsis thaliana)
eudicotyledons AT1G71350 35
  • 46.21 (n)
  • 35.27 (a)
rice
(Oryza sativa)
Liliopsida Os02g0557600 35
  • 44.72 (n)
  • 34.33 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 36 (a)
OneToOne
Species with no ortholog for EIF2D:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for EIF2D Gene

ENSEMBL:
Gene Tree for EIF2D (if available)
TreeFam:
Gene Tree for EIF2D (if available)

Paralogs for EIF2D Gene

No data available for Paralogs for EIF2D Gene

Variants for EIF2D Gene

Sequence variations from dbSNP and Humsavar for EIF2D Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs35252702 - 206,603,106(-) CTCCA(C/T)CCTGC intron-variant, nc-transcript-variant, reference, missense
rs1127810 -- 206,594,169(-) CAGGG(A/G)TATAG intron-variant
rs3813966 -- 206,614,518(-) AAAGT(C/T)CCCCT upstream-variant-2KB
rs3813967 -- 206,612,653(-) ACGGG(C/G)AACCC upstream-variant-2KB
rs3813968 -- 206,612,651(-) GGGGA(A/T)CCCGA upstream-variant-2KB

Variation tolerance for EIF2D Gene

Residual Variation Intolerance Score: 20.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.57; 56.07% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for EIF2D Gene

HapMap Linkage Disequilibrium report
EIF2D

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for EIF2D Gene

Disorders for EIF2D Gene

Relevant External Links for EIF2D

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
EIF2D

No disorders were found for EIF2D Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for EIF2D Gene

Publications for EIF2D Gene

  1. GTP-independent tRNA delivery to the ribosomal P-site by a novel eukaryotic translation factor. (PMID: 20566627) Dmitriev S.E. … Shatsky I.N. (J. Biol. Chem. 2010) 2 3 4 67
  2. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  3. Panorama of ancient metazoan macromolecular complexes. (PMID: 26344197) Wan C. … Emili A. (Nature 2015) 3
  4. Solubility-based genetic screen identifies RING finger protein 126 as an E3 ligase for activation-induced cytidine deaminase. (PMID: 23277564) Delker R.K. … Papavasiliou F.N. (Proc. Natl. Acad. Sci. U.S.A. 2013) 3
  5. A census of human soluble protein complexes. (PMID: 22939629) Havugimana P.C. … Emili A. (Cell 2012) 3

Products for EIF2D Gene

Sources for EIF2D Gene

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