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Aliases for EIF2D Gene

Aliases for EIF2D Gene

  • Eukaryotic Translation Initiation Factor 2D 2 3 5
  • Hepatocellular Carcinoma-Associated Antigen 56 3 4
  • Ligatin 3 4
  • HCA56 3 4
  • LGTN 3 4
  • EIF2d 4

External Ids for EIF2D Gene

Previous GeneCards Identifiers for EIF2D Gene

  • GC01M206745

Summaries for EIF2D Gene

Entrez Gene Summary for EIF2D Gene

  • This gene encodes a translation initiation factor involved in the recruitment and delivery of aminoacyl-tRNAs to the P-site of the eukaryotic ribosome in a GTP-independent manner. This gene was previously referred to as ligatin, but is now known to localize to the cytoplasm and localize and function with translation factors. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2011]

GeneCards Summary for EIF2D Gene

EIF2D (Eukaryotic Translation Initiation Factor 2D) is a Protein Coding gene. GO annotations related to this gene include RNA binding and translation initiation factor activity.

UniProtKB/Swiss-Prot for EIF2D Gene

  • Translation initiation factor that is able to deliver tRNA to the P-site of the eukaryotic ribosome in a GTP-independent manner. The binding of Met-tRNA(I) occurs after the AUG codon finds its position in the P-site of 40S ribosomes, the situation that takes place during initiation complex formation on some specific RNAs. Its activity in tRNA binding with 40S subunits does not require the presence of the aminoacyl moiety. Possesses the unique ability to deliver non-Met (elongator) tRNAs into the P-site of the 40S subunit. In addition to its role in initiation, can promote release of deacylated tRNA and mRNA from recycled 40S subunits following ABCE1-mediated dissociation of post-termination ribosomal complexes into subunits.

Gene Wiki entry for EIF2D Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for EIF2D Gene

Genomics for EIF2D Gene

Regulatory Elements for EIF2D Gene

Enhancers for EIF2D Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH01F206573 1.8 FANTOM5 Ensembl ENCODE 17.7 +33.8 33790 11.1 HDGF PKNOX1 ATF1 ARNT CREB3L1 ZNF2 ELK1 GATA2 ZNF143 ZNF207 RASSF5 MAPKAPK2 EIF2D IKBKE C1orf147 DYRK3 IL19 FCMR PIR41610 ENSG00000279946
GH01F206586 1.2 FANTOM5 ENCODE 24.1 +23.3 23275 6.4 CTCF CBX3 ATF1 JUN CEBPG TEAD3 ZNF664 CTBP1 ZNF366 POLR2A RASSF5 EIF2D MAPKAPK2 C1orf147 IKBKE PIR41610 ENSG00000279946
GH01F206554 1.4 Ensembl ENCODE 18 +49.6 49643 16.8 HDGF PKNOX1 ARNT MLX CREB3L1 WRNIP1 ZFP64 SIN3A ARID4B ZNF766 EIF2D RASSF5 C1orf147 IKBKE MAPKAPK2 ENSG00000279946 PIR41610
GH01F206550 1.5 FANTOM5 Ensembl ENCODE 15.4 +60.6 60640 2.1 HDAC1 HDGF CBX3 PKNOX1 SIN3A ZNF2 RAD21 YY1 ZNF121 SCRT2 RASSF5 EIF2D MAPKAPK2 IKBKE C1orf147 FCMR ENSG00000279946 PIR41610
GH01F206657 1.5 FANTOM5 Ensembl ENCODE 11.1 -46.3 -46269 3.4 HDGF CBX3 TBL1XR1 RAD21 RARA YY1 GLIS2 GATA2 ZNF143 ETV6 DYRK3 IKBKE MAPKAPK2 EIF2D C1orf147 RASSF5 PIR60472 LOC105372875
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around EIF2D on UCSC Golden Path with GeneCards custom track

Promoters for EIF2D Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001528008 151 1600 CREB3L1 ZFP64 FEZF1 DMAP1 YY1 SLC30A9 ZNF143 ZNF548 SP3 NFYC

Genomic Location for EIF2D Gene

Chromosome:
1
Start:
206,571,292 bp from pter
End:
206,612,551 bp from pter
Size:
41,260 bases
Orientation:
Minus strand

Genomic View for EIF2D Gene

Genes around EIF2D on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
EIF2D Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for EIF2D Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for EIF2D Gene

Proteins for EIF2D Gene

  • Protein details for EIF2D Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P41214-EIF2D_HUMAN
    Recommended name:
    Eukaryotic translation initiation factor 2D
    Protein Accession:
    P41214
    Secondary Accessions:
    • Q5SY40
    • Q8IXV3
    • Q96DG3
    • Q96TG7
    • Q9NR27
    • Q9NSN0
    • Q9NV18
    • Q9NZ21

    Protein attributes for EIF2D Gene

    Size:
    584 amino acids
    Molecular mass:
    64706 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for EIF2D Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for EIF2D Gene

Post-translational modifications for EIF2D Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Antibody Products

  • Cloud-Clone Corp. Antibodies for EIF2D
  • Santa Cruz Biotechnology (SCBT) Antibodies for EIF2D

No data available for DME Specific Peptides for EIF2D Gene

Domains & Families for EIF2D Gene

Protein Domains for EIF2D Gene

Suggested Antigen Peptide Sequences for EIF2D Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P41214

UniProtKB/Swiss-Prot:

EIF2D_HUMAN :
  • Contains 1 PUA domain.
  • Belongs to the eIF2D family.
Domain:
  • Contains 1 PUA domain.
  • Contains 1 SUI1 domain.
Family:
  • Belongs to the eIF2D family.
genes like me logo Genes that share domains with EIF2D: view

No data available for Gene Families for EIF2D Gene

Function for EIF2D Gene

Molecular function for EIF2D Gene

UniProtKB/Swiss-Prot Function:
Translation initiation factor that is able to deliver tRNA to the P-site of the eukaryotic ribosome in a GTP-independent manner. The binding of Met-tRNA(I) occurs after the AUG codon finds its position in the P-site of 40S ribosomes, the situation that takes place during initiation complex formation on some specific RNAs. Its activity in tRNA binding with 40S subunits does not require the presence of the aminoacyl moiety. Possesses the unique ability to deliver non-Met (elongator) tRNAs into the P-site of the 40S subunit. In addition to its role in initiation, can promote release of deacylated tRNA and mRNA from recycled 40S subunits following ABCE1-mediated dissociation of post-termination ribosomal complexes into subunits.

Gene Ontology (GO) - Molecular Function for EIF2D Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003723 RNA binding IEA --
GO:0003743 translation initiation factor activity IDA 20566627
GO:0004872 receptor activity TAS 2482295
GO:0005509 calcium ion binding IEA --
genes like me logo Genes that share ontologies with EIF2D: view
genes like me logo Genes that share phenotypes with EIF2D: view

Animal Model Products

miRNA for EIF2D Gene

miRTarBase miRNAs that target EIF2D

Inhibitory RNA Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for EIF2D Gene

Localization for EIF2D Gene

Subcellular locations from UniProtKB/Swiss-Prot for EIF2D Gene

Cytoplasm.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for EIF2D gene
Compartment Confidence
nucleus 5
cytosol 5

Gene Ontology (GO) - Cellular Components for EIF2D Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA --
GO:0005737 cytoplasm IDA,TAS 20566627
GO:0022627 colocalizes_with cytosolic small ribosomal subunit IDA 20713520
genes like me logo Genes that share ontologies with EIF2D: view

Pathways & Interactions for EIF2D Gene

SuperPathways for EIF2D Gene

No Data Available

Gene Ontology (GO) - Biological Process for EIF2D Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001731 formation of translation preinitiation complex IDA 20713520
GO:0002192 IRES-dependent translational initiation IDA 20713520
GO:0006412 translation IEA --
GO:0006413 translational initiation IEA --
GO:0006886 intracellular protein transport TAS 2482295
genes like me logo Genes that share ontologies with EIF2D: view

No data available for Pathways by source and SIGNOR curated interactions for EIF2D Gene

Drugs & Compounds for EIF2D Gene

(1) Drugs for EIF2D Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(1) Additional Compounds for EIF2D Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with EIF2D: view

Transcripts for EIF2D Gene

Unigene Clusters for EIF2D Gene

Eukaryotic translation initiation factor 2D:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for EIF2D Gene

ExUns: 1 ^ 2a · 2b · 2c · 2d ^ 3a · 3b ^ 4 ^ 5a · 5b · 5c ^ 6 ^ 7 ^ 8 ^ 9 ^ 10a · 10b ^ 11 ^ 12a · 12b ^ 13 ^ 14 ^ 15a · 15b ^ 16 ^ 17
SP1: - - - -
SP2: - - - - - -
SP3: - - - - - - -
SP4: - - -
SP5: - - - -
SP6: - - -
SP7: - - -
SP8:
SP9:

Relevant External Links for EIF2D Gene

GeneLoc Exon Structure for
EIF2D
ECgene alternative splicing isoforms for
EIF2D

Expression for EIF2D Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for EIF2D Gene

Protein differential expression in normal tissues from HIPED for EIF2D Gene

This gene is overexpressed in Breast (24.6) and Esophagus (9.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for EIF2D Gene



Protein tissue co-expression partners for EIF2D Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of EIF2D Gene:

EIF2D

SOURCE GeneReport for Unigene cluster for EIF2D Gene:

Hs.497581
genes like me logo Genes that share expression patterns with EIF2D: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for EIF2D Gene

Orthologs for EIF2D Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for EIF2D Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia EIF2D 34 35
  • 99.6 (n)
cow
(Bos Taurus)
Mammalia EIF2D 34 35
  • 89.06 (n)
dog
(Canis familiaris)
Mammalia EIF2D 34 35
  • 89.02 (n)
rat
(Rattus norvegicus)
Mammalia Eif2d 34
  • 85.91 (n)
mouse
(Mus musculus)
Mammalia Eif2d 34 16 35
  • 85.61 (n)
oppossum
(Monodelphis domestica)
Mammalia EIF2D 35
  • 69 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia EIF2D 35
  • 59 (a)
OneToOne
chicken
(Gallus gallus)
Aves EIF2D 34 35
  • 66.9 (n)
lizard
(Anolis carolinensis)
Reptilia EIF2D 35
  • 59 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia eif2d 34
  • 62.41 (n)
MGC76058 34
zebrafish
(Danio rerio)
Actinopterygii eif2d 34 35
  • 60.71 (n)
zgc63669 34
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.13929 34
fruit fly
(Drosophila melanogaster)
Insecta ligatin 34 35
  • 47.88 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP011804 34
  • 45.57 (n)
worm
(Caenorhabditis elegans)
Secernentea CELE_C25H3.4 34
  • 44.47 (n)
C25H3.4 35
  • 30 (a)
OneToOne
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes TMA64 35 37
  • 24 (a)
OneToOne
thale cress
(Arabidopsis thaliana)
eudicotyledons AT1G71350 34
  • 46.21 (n)
rice
(Oryza sativa)
Liliopsida Os02g0557600 34
  • 44.72 (n)
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 36 (a)
OneToOne
Species where no ortholog for EIF2D was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for EIF2D Gene

ENSEMBL:
Gene Tree for EIF2D (if available)
TreeFam:
Gene Tree for EIF2D (if available)

Paralogs for EIF2D Gene

No data available for Paralogs for EIF2D Gene

Variants for EIF2D Gene

Sequence variations from dbSNP and Humsavar for EIF2D Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs10494877 -- 206,610,114(+) TATGG(G/T)TAAAG intron-variant
rs10779488 -- 206,586,643(+) ATTTT(A/G)TTGCT intron-variant
rs10863711 -- 206,572,397(+) AGAAT(C/T)GAGTA intron-variant, downstream-variant-500B
rs10863727 -- 206,609,060(+) AAAAA(A/T)AAAAT intron-variant
rs11119069 -- 206,572,803(+) atata(A/T)ttttc intron-variant

Variation tolerance for EIF2D Gene

Residual Variation Intolerance Score: 20.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.57; 56.07% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for EIF2D Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
EIF2D

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for EIF2D Gene

Disorders for EIF2D Gene

Relevant External Links for EIF2D

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
EIF2D

No disorders were found for EIF2D Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for EIF2D Gene

Publications for EIF2D Gene

  1. GTP-independent tRNA delivery to the ribosomal P-site by a novel eukaryotic translation factor. (PMID: 20566627) Dmitriev S.E. … Shatsky I.N. (J. Biol. Chem. 2010) 2 3 4 64
  2. Activities of ligatin and MCT-1/DENR in eukaryotic translation initiation and ribosomal recycling. (PMID: 20713520) Skabkin M.A. … Pestova T.V. (Genes Dev. 2010) 3 4 64
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  4. Large scale identification of human hepatocellular carcinoma- associated antigens by autoantibodies. (PMID: 12097419) Wang Y. … Chen W.-F. (J. Immunol. 2002) 3 4 64
  5. Molecular cloning of the cDNA for ligatin. (PMID: 2482295) Jakoi E.R. … Snyderman R. (J. Cell Sci. 1989) 3 4 64

Products for EIF2D Gene

Sources for EIF2D Gene

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