Aliases for EIF2B5 Gene
External Ids for EIF2B5 Gene
Previous GeneCards Identifiers for EIF2B5 Gene
This gene encodes one of five subunits of eukaryotic translation initiation factor 2B (EIF2B), a GTP exchange factor for eukaryotic initiation factor 2 and an essential regulator for protein synthesis. Mutations in this gene and the genes encoding other EIF2B subunits have been associated with leukoencephalopathy with vanishing white matter. [provided by RefSeq, Nov 2009]
GeneCards Summary for EIF2B5 Gene
EIF2B5 (Eukaryotic Translation Initiation Factor 2B, Subunit 5 Epsilon, 82kDa) is a Protein Coding gene. Diseases associated with EIF2B5 include leukoencephalopathy with vanishing white matter and late infantile cach syndrome. Among its related pathways are Apoptotic Pathways in Synovial Fibroblasts and Nanog in Mammalian ESC Pluripotency. GO annotations related to this gene include binding and translation initiation factor activity.
UniProtKB/Swiss-Prot for EIF2B5 Gene
Catalyzes the exchange of eukaryotic initiation factor 2-bound GDP for GTP