Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 
or upload a file of gene symbols


Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

EIF2B2 Gene

protein-coding   GIFtS: 65
GCID: GC14P075469

Eukaryotic Translation Initiation Factor 2B, Subunit 2 Beta,...

(Previous names: eukaryotic translation initiation factor 2B, subunit 2 (beta,...)
Alzheimer's & Parkinson's Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Eukaryotic Translation Initiation Factor 2B, Subunit 2 Beta, 39kDa1 2     EIF-2Bbeta2
S20I152 3     EIF2B2
S20III152 3     Translation Initiation Factor EIF-2B Subunit Beta2
EIF-2B GDP-GTP Exchange Factor Subunit Beta2 3     EIF2BB3
Eukaryotic Translation Initiation Factor 2B, Subunit 2 (Beta, 39kD)1     

External Ids:    HGNC: 32581   Entrez Gene: 88922   Ensembl: ENSG000001197187   OMIM: 6064545   UniProtKB: P497703   

Export aliases for EIF2B2 gene to outside databases

Previous GC identifers: GC14P072996 GC14P069286 GC14P073459 GC14P074539 GC14P055637


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for EIF2B2 Gene:
This gene encodes the beta subunit of eukaryotic initiation factor-2B (EIF2B). EIF2B is involved in protein
synthesis and exchanges GDP and GTP for its activation and deactivation. (provided by RefSeq, Aug 2011)

GeneCards Summary for EIF2B2 Gene: 
EIF2B2 (eukaryotic translation initiation factor 2B, subunit 2 beta, 39kDa) is a protein-coding gene. Diseases associated with EIF2B2 include eif2b2-related childhood ataxia with central nervous system hypomyelination/vanishing white matter, and ovarioleukodystrophy, and among its related super-pathways are GTP hydrolysis and joining of the 60S ribosomal subunit and Translation Insulin regulation of translation. GO annotations related to this gene include GTP binding and translation initiation factor activity.

UniProtKB/Swiss-Prot: EI2BB_HUMAN, P49770
Function: Catalyzes the exchange of eukaryotic initiation factor 2-bound GDP for GTP

Gene Wiki entry for EIF2B2 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000014.8  NC_018925.2  NT_026437.12  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the EIF2B2 gene promoter:
         TBP   Elk-1   AML1a   XBP-1   CUTL1   RelA   c-Ets-1   PPAR-gamma1   TFIID   PPAR-gamma2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidEIF2B2 promoter sequence
   Search SABiosciences Chromatin IP Primers for EIF2B2

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat EIF2B2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 14q24.3   Ensembl cytogenetic band:  14q24.3   HGNC cytogenetic band: 14q24.3

EIF2B2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
EIF2B2 gene location

GeneLoc information about chromosome 14         GeneLoc Exon Structure

GeneLoc location for GC14P075469:  view genomic region     (about GC identifiers)

Start:
75,469,612 bp from pter      End:
75,476,294 bp from pter
Size:
6,683 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: EI2BB_HUMAN, P49770 (See protein sequence)
Recommended Name: Translation initiation factor eIF-2B subunit beta  
Size: 351 amino acids; 38990 Da
Subunit: Complex of five different subunits; alpha, beta, gamma, delta and epsilon
Sequence caution: Sequence=AAC42002.1; Type=Frameshift; Positions=Several;
Secondary accessions: O43201

Explore the universe of human proteins at neXtProt for EIF2B2: NX_P49770

Explore proteomics data for EIF2B2 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_P49770

  • EIF2B2 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    EIF2B2 Protein Expression
    REFSEQ proteins: NP_055054.1  
    ENSEMBL proteins: 
     ENSP00000266126   ENSP00000452311   ENSP00000451681   ENSP00000452582  
    Reactome Protein details: P49770
    Human Recombinant Protein Products for EIF2B2: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein for EIF2B2
    OriGene Protein Over-expression Lysate for EIF2B2
    OriGene MassSpec for EIF2B2 
    OriGene Custom Protein Services for EIF2B2
    GenScript Custom Purified and Recombinant Proteins Services for EIF2B2
    Novus Biologicals EIF2B2 Protein
    Novus Biologicals EIF2B2 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for EIF2B2 

    Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm IDA11323413
    GO:0005829cytosol TAS--
    GO:0005851eukaryotic translation initiation factor 2B complex IDA11323413

    EIF2B2 for ontologies           About GeneDecksing



    EIF2B2 Antibody Products: 
    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    OriGene Antibodies for EIF2B2
    OriGene Custom Antibody Services for EIF2B2
    GenScript Custom Superior Antibodies Services for EIF2B2
    Novus Biologicals EIF2B2 Antibodies
    Abcam antibodies for EIF2B2
    Cloud-Clone Corp. Antibodies for EIF2B2 
    ThermoFisher Antibodies for EIF2B2
    LSBio Antibodies in human, mouse, rat for EIF2B2 

    Assay Products for EIF2B2: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for EIF2B2
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for EIF2B2
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for EIF2B2 
    Cloud-Clone Corp. CLIAs for EIF2B2


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    1 InterPro protein domain:
     IPR000649 IF-2B-related

    Graphical View of Domain Structure for InterPro Entry P49770

    ProtoNet protein and cluster: P49770

    1 Blocks protein domain: IPB000649 Initiation factor 2B

    UniProtKB/Swiss-Prot: EI2BB_HUMAN, P49770
    Similarity: Belongs to the eIF-2B alpha/beta/delta subunits family


    EIF2B2 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: EI2BB_HUMAN, P49770
    Function: Catalyzes the exchange of eukaryotic initiation factor 2-bound GDP for GTP

         Gene Ontology (GO): 5/6 molecular function terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003743contributes to translation initiation factor activity IDA16289705
    GO:0005085contributes to guanyl-nucleotide exchange factor activity IMP15054402
    GO:0005515protein binding IPI15060152
    GO:0005524ATP binding IDA11323413
    GO:0005525GTP binding IDA11323413
         
    EIF2B2 for ontologies           About GeneDecksing


    Phenotypes:
         4 GenomeRNAi human phenotypes for EIF2B2:
     Decreased NANOG protein expres  Decreased OCT4 protein express  Decreased POU5F1-GFP protein e  Decreased viability with pacli 

         2 MGI mutant phenotypes (inferred from 1 allele(MGI details for Eif2b2):
     immune system  mortality/aging 

    EIF2B2 for phenotypes           About GeneDecksing

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for EIF2B2 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for EIF2B2

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for EIF2B2 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for EIF2B2 

    miRNA
    Products:
        
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat EIF2B2
    2 QIAGEN miScript miRNA Assays for microRNAs that regulate EIF2B2:
    hsa-miR-4303 hsa-miR-4291
    SwitchGear 3'UTR luciferase reporter plasmidEIF2B2 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for EIF2B2
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat EIF2B2

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for EIF2B2
    Sirion Biotech Customized adenovirus for overexpression of EIF2B2

    Clone
    Products:
         
    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene clones in human, mouse for EIF2B2 (see all 6)
    OriGene ORF clones in mouse, rat for EIF2B2
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: EIF2B2 (NM_014239)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for EIF2B2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat EIF2B2
    Sirion Biotech Customized lentivirus for stable overexpression of EIF2B2 
                         Customized lentivirus expression plasmids for stable overexpression of EIF2B2 

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for EIF2B2
    Search LifeMap BioReagents cell lines for EIF2B2
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for EIF2B2


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for EIF2B2 About   (see all 11)                                                                                              See pathways by source

    SuperPathContained pathways About
    1Viral mRNA Translation
    Cap-dependent Translation Initiation0.94
    Translation0.78
    Eukaryotic Translation Initiation0.94
    2Translation Insulin regulation of translation
    Translation Insulin regulation of translation0.59
    Translation Regulation activity of EIF20.47
    3NFAT and Cardiac Hypertrophy
    Signaling Involved in Cardiac Hypertrophy0.42
    IGF1R Signaling0.37
    4Nanog in Mammalian ESC Pluripotency
    GSK3 Signaling0.61
    5Apoptotic Pathways in Synovial Fibroblasts
    eIF2 Pathway0.60

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    2 EMD Millipore Pathways for EIF2B2
        Translation Insulin regulation of translation
    Translation Regulation activity of EIF2

    5 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for EIF2B2
        IGF1R Signaling
    GSK3 Signaling
    eIF2 Pathway
    Signaling Involved in Cardiac Hypertrophy
    Insulin Receptor Pathway

    2 GeneGo (Thomson Reuters) Pathways for EIF2B2
        Translation Insulin regulation of translation
    Translation Regulation of EIF2 activity

    1 BioSystems Pathway for EIF2B2
        Translation Factors

    5/6        Reactome Pathways for EIF2B2 (see all 6)
        Cap-dependent Translation Initiation
    Translation
    Eukaryotic Translation Initiation
    Metabolism of proteins
    Gene Expression


    1         Kegg Pathway  (Kegg details for EIF2B2):
        RNA transport


    EIF2B2 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for EIF2B2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/127 Interacting proteins for EIF2B2 (P497703 ENSP000002661264) via UniProtKB, MINT, STRING, and/or I2D (see all 127)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    HIST1H4AP628053I2D: score=1 
    HIST1H4BP628053I2D: score=1 
    HIST1H4CP628053I2D: score=1 
    HIST1H4DP628053I2D: score=1 
    HIST1H4EP628053I2D: score=1 
    About this table

    Gene Ontology (GO): 5/15 biological process terms (GO ID links to tree view) (see all 15):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001541ovarian follicle development IMP15507143
    GO:0006412translation TAS--
    GO:0006413translational initiation TAS--
    GO:0006446regulation of translational initiation TAS15060152
    GO:0007417central nervous system development IMP15776425

    EIF2B2 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    EIF2B2 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for EIF2B2 (EI2BB)

    1 HMDB Compound for EIF2B2    About this table
    CompoundSynonyms CAS #PubMed Ids
    Guanosine triphosphate5'-GTP (see all 10)86-01-1--

    2 Novoseek inferred chemical compound relationships for EIF2B2 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    gdp 43.3 2 11323413 (1)
    gtp 41.7 3 11323413 (2)

    Search CenterWatch for drugs/clinical trials and news about EIF2B2 / EI2BB

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for EIF2B2 gene: 
    NM_014239.3  

    Unigene Cluster for EIF2B2:

    Eukaryotic translation initiation factor 2B, subunit 2 beta, 39kDa
    Hs.409137  [show with all ESTs]
    Unigene Representative Sequence: NM_014239
    7 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000266126(uc001xrc.2) ENST00000555522 ENST00000553539 ENST00000556028
    ENST00000553401 ENST00000554748 ENST00000556668

    miRNA
    Products:
         
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat EIF2B2
    2 QIAGEN miScript miRNA Assays for microRNAs that regulate EIF2B2:
    hsa-miR-4303 hsa-miR-4291
    SwitchGear 3'UTR luciferase reporter plasmidEIF2B2 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for EIF2B2
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat EIF2B2
    Clone
    Products:
         
    OriGene clones in human, mouse for EIF2B2 (see all 6)
    OriGene ORF clones in mouse, rat for EIF2B2
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: EIF2B2 (NM_014239)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for EIF2B2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat EIF2B2
    Sirion Biotech Customized lentivirus for stable overexpression of EIF2B2 
                         Customized lentivirus expression plasmids for stable overexpression of EIF2B2 
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for EIF2B2
    OriGene qSTAR qPCR primer pairs in human, mouse for EIF2B2
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat EIF2B2
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat EIF2B2
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat EIF2B2

    Additional mRNA sequence: 

    AF035280.1 BC000494.2 BC003165.1 BC011750.2 BX161473.1 L40395.1 

    10 DOTS entries:

    DT.446846  DT.100815960  DT.97803005  DT.65287984  DT.95194987  DT.75130736  DT.91793197  DT.95194997 
    DT.120787524  DT.40238494 

    24/261 AceView cDNA sequences (see all 261):

    BI770544 AA236363 BX284057 BQ686676 AA352748 BI908906 BM807327 CR622961 
    CR625991 BX368101 BX161473 AA300667 BC003165 BU160162 AI344669 BC000494 
    CR608189 BI792961 NM_014239 BU159658 CB107045 BU949753 CD516347 AF035280 

    GeneLoc Exon Structure

    4 Alternative Splicing Database (ASD) splice patterns (SP) for EIF2B2    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b ^ 5a · 5b · 5c ^ 6 ^ 7 ^ 8 ^ 9
    SP1:                                -                             -               
    SP2:                                -     -                                       
    SP3:                                                                              
    SP4:                                                                              


    ECgene alternative splicing isoforms for EIF2B2

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    EIF2B2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TTTTATGACC
    EIF2B2 Expression
    About this image


    See EIF2B2 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for EIF2B2

    SOURCE GeneReport for Unigene cluster: Hs.409137
        SABiosciences Custom PCR Arrays for EIF2B2
    Primer
    Products:
    OriGene qPCR primer pairs and template standards for EIF2B2
    OriGene qSTAR qPCR primer pairs in human, mouse for EIF2B2
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat EIF2B2
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat EIF2B2
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat EIF2B2
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for EIF2B2

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of eukaryotes.

    Orthologs for EIF2B2 gene from 10/24 species (see all 24)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Eif2b21 , 5 eukaryotic translation initiation factor 2B, subunit more1, 5 89.08(n)1
    94.02(a)1
      12 (39.60 cM)5
    2177151  NM_145445.31  NP_663420.11 
     852194815 
    chicken
    (Gallus gallus)
    Aves EIF2B21 eukaryotic translation initiation factor 2B, subunit more 79.01(n)
    83.76(a)
      423359  NM_001006481.1  NP_001006481.1 
    lizard
    (Anolis carolinensis)
    Reptilia EIF2B26
    Uncharacterized protein
    83(a)
    1 ↔ 1
    1(22622924-22632369)
    African clawed frog
    (Xenopus laevis)
    Amphibia BC041556.12   -- 77.22(n)    BC041556.1 
    zebrafish
    (Danio rerio)
    Actinopterygii Dr.46262 Transcribed sequence with moderate similarity to protein more 76.63(n)    57072749 
    fruit fly
    (Drosophila melanogaster)
    Insecta eIF2B-&bgr;3
    eIF2B-beta1
    translational initiation translation
    initiation more3
    CG2677-PA1
    48(a)3
    56.89(n)1
    50.47(a)1
      3B33
    312561  NM_130664.31  NP_570020.11 
    worm
    (Caenorhabditis elegans)
    Secernentea Y47H9C.76
    Protein Y47H9C.7
    24(a)
    1 ↔ 1
    I(11891574-11893729)
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes GCD7(YLR291C)4
    GCD71
    Beta subunit of the translation initiation factor eIF2B, more4
    Gcd7p1
    44.81(n)1
    35.91(a)1
      12(719462-718317)4
    8509981, 4  NP_013394.11, 4 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons AT3G073001 translation initiation factor eIF-2B beta subunit 51.12(n)
    45.16(a)
      819918  NM_001035578.1  NP_001030655.1 
    rice
    (Oryza sativa)
    Liliopsida Os10g03927001 hypothetical protein 51.44(n)
    44.88(a)
      4348536  NM_001071051.1  NP_001064516.2 


    ENSEMBL Gene Tree for EIF2B2 (if available)
    TreeFam Gene Tree for EIF2B2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for EIF2B2 gene
    1 SIMAP similar gene for EIF2B2 using alignment to 6 protein entries:     EI2BB_HUMAN (see all proteins):
    EIF2B1

    EIF2B2 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/235 SNPs in EIF2B2 are shown (see all 235)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 14 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0684514
    Leukodystrophy with vanishing white matter (VWM)4--see VAR_0684512 V E mis40--------
    VAR_0684524
    Leukodystrophy with vanishing white matter (VWM)4--see VAR_0684522 P S mis40--------
    VAR_0123214
    Leukodystrophy with vanishing white matter (VWM)4--see VAR_0123212 K R mis40--------
    VAR_0122904
    Leukodystrophy with vanishing white matter (VWM)4--see VAR_0122902 V D mis40--------
    VAR_0122894
    Leukodystrophy with vanishing white matter (VWM)4--see VAR_0122892 E G mis40--------
    VAR_0684544
    Leukodystrophy with vanishing white matter (VWM)4--see VAR_0684542 C Y mis40--------
    VAR_0123224
    Leukodystrophy with vanishing white matter (VWM)4--see VAR_0123222 G V mis40--------
    VAR_0168424
    Leukodystrophy with vanishing white matter (VWM)4--see VAR_0168422 S F mis40--------
    VAR_0684534
    Leukodystrophy with vanishing white matter (VWM)4--see VAR_0684532 G V mis40--------
    rs1048944281,2
    Cpathogenic156462440(+) CTTCTC/TCCGAA 2 S F mis10--------

    HapMap Linkage Disequilibrium report for EIF2B2 (75469612 - 75476294 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for EIF2B2: --

    Human Gene Mutation Database (HGMD): EIF2B2
    SABiosciences Cancer Mutation PCR Assays
    Search QIAGEN SeqTarget long-range PCR primers for resequencing EIF2B2
    DNA2.0 Custom Variant and Variant Library Synthesis for EIF2B2

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 606454   
    OMIM disorders: 603896  
    UniProtKB/Swiss-Prot: EI2BB_HUMAN, P49770
  • Leukodystrophy with vanishing white matter (VWM) [MIM:603896]: A leukodystrophy that occurs mainly in
    children. Neurological signs include progressive cerebellar ataxia, spasticity, inconstant optic atrophy and
    relatively preserved mental abilities. The disease is chronic-progressive with, in most individuals, additional
    episodes of rapid deterioration following febrile infections or minor head trauma. While childhood onset is the
    most common form of the disorder, some severe forms are apparent at birth. A severe, early-onset form seen among
    the Cree and Chippewayan populations of Quebec and Manitoba is called Cree leukoencephalopathy. Milder forms may
    not become evident until adolescence or adulthood. Some females with milder forms of the disease who survive to
    adolescence exhibit ovarian dysfunction. This variant of the disorder is called ovarioleukodystrophy. Note=The
    disease is caused by mutations affecting the gene represented in this entry

  • 14 diseases for EIF2B2:    About MalaCards
    eif2b2-related childhood ataxia with central nervous system hypomyelination/vanishing white matter    ovarioleukodystrophy    leukodystrophy    was-related disorders
    optic atrophy    premature ovarian failure    cerebellar ataxia    adrenoleukodystrophy
    ataxia    bipolar disorder    spasticity    alzheimer's disease
    multiple sclerosis    schizophrenia


    EIF2B2 for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:  
    Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015

    2 Novoseek inferred disease relationships for EIF2B2 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    leukodystrophy 69.6 2 12707859 (1)
    shock 5.77 1 16185887 (1)

    GeneTests: EIF2B2
    GeneReviews: EIF2B2
    Genetic Association Database (GAD): EIF2B2
    Human Genome Epidemiology (HuGE) Navigator: EIF2B2 (5 documents)

    Export disorders for EIF2B2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for EIF2B2 gene, integrated from 9 sources (see all 64):
    (articles sorted by number of sources associating them with EIF2B2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Identification of ten novel mutations in patients with eIF2B-related disorders. (PubMed id 15776425)1, 2, 9 Ohlenbusch A....Gartner J. (2005)
    2. Ovarian failure related to eukaryotic initiation factor 2B mutations. (PubMed id 12707859)1, 2, 9 Fogli A....Boespflug-Tanguy O. (2003)
    3. Subunits of the translation initiation factor eIF2B are mutant in leukoencephalopathy with vanishing white matter. (PubMed id 11704758)1, 2, 9 Leegwater P.A.J.... van der Knaap M.S. (2001)
    4. Vanishing white matter disease caused by EIF2B2 mutati on with the presentation of an adrenoleukodystrophy phenotype. (PubMed id 22285377)1, 2 Alsalem A....Alkuraya F.S. (2012)
    5. A large-scale candidate gene association study of age at menarche and age at natural menopause. (PubMed id 20734064)1, 4 He C....Hunter D.J. (2010)
    6. Variation at the NFATC2 locus increases the risk of t hiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipr il and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1, 4 Bailey S.D....Anand S. (2010)
    7. No evidence that polymorphisms of the vanishing white matter disease genes are risk factors in multiple sclerosis. (PubMed id 18632786)1, 4 Pronk J....van der Knaap M. (2008)
    8. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    9. The DNA sequence and analysis of human chromosome 14. (PubMed id 12508121)1, 2 Heilig R.... Weissenbach J. (2003)
    10. Identification of a regulatory subcomplex in the guanine nucleotide exchange factor eIF2B that mediates inhibition by phosphorylated eIF2. (PubMed id 8887689)1, 3 Yang W. and Hinnebusch A.G. (1996)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 8892 HGNC: 3258 AceView: EIF2B2 Ensembl:ENSG00000119718 euGenes: HUgn8892
    ECgene: EIF2B2 Kegg: 8892 H-InvDB: EIF2B2

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for EIF2B2 Pharmacogenomics, SNPs, Pathways
    GeneReviewshttp://www.ncbi.nlm.nih.gov/sites/GeneTests/lab/gene/EIF2B2

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for EIF2B2 gene:
    Search GeneIP for patents involving EIF2B2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

     
     EMD Millipore Custom Antibody & Bulk Services
     EMD Millipore Preclinical / Clinical Development Services
     EMD Millipore Immunoassay Services
     EMD Millipore Target Screening & Profiling Services

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Kinase Activity Assays/Reagents  
     Browse ELISpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Multiplex/Array Assay Kits/Reagents  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Protease Activity Assays and Reagents   Browse Recombinant/Natural Proteins  
     Browse Stem Cell Products   Browse Tocris Biochemicals & Compounds  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     OriGene Antibodies for EIF2B2   OriGene RNAi products in human, mouse, rat for EIF2B2  
     OriGene qPCR primer pairs and template standards for EIF2B2   OriGene Protein Over-expression Lysate for EIF2B2  
     OriGene MassSpec something-or-other for EIF2B2   OriGene clones in human, mouse for EIF2B2  
     OriGene qSTAR qPCR primer pairs in human, mouse for EIF2B2   OriGene Purified Protein for EIF2B2  
     OriGene ORF clones in mouse, rat for EIF2B2   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for EIF2B2   OriGene Custom Protein Services for EIF2B2  

     
     
     QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat EIF2B2
     QIAGEN SeqTarget long-range PCR primers for resequencing EIF2B2
     QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat EIF2B2
     QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat EIF2B2
     QIAGEN QuantiFast Probe-based Assays in human, mouse, rat EIF2B2
     QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat EIF2B2
     GenScript Custom Purified and Recombinant Proteins Services for EIF2B2 GenScript cDNA clones with any tag delivered in your preferred vector for EIF2B2
     GenScript Custom Assay Services for EIF2B2 GenScript Custom Superior Antibodies Services for EIF2B2
     GenScript Custom overexpressing Cell Line Services for EIF2B2 CloneReady with Over 120,000 Genes
     Gene Synthesis: Any Gene in Any Vector Vector-based siRNA and miRNA, Ready for Transfection
     Gene Mutant Library, Variants up to 10^11 Plasmid Preparation
     Custom Peptide Services
     Search for Antibodies & Assays

     Regulatory tfbs in EIF2B2 promoter
     Search Chromatin IP Primers for EIF2B2
     RT2 qPCR Primer Assay in human, mouse, rat EIF2B2
     GNC Network for EIF2B2
     SABiosciences PCR Arrays including human, mouse, rat EIF2B2
     Search Tocris compounds for EIF2B2 (EI2BB)
     Browse Sino Biological Proteins and Antibodies
     Browse Sino Biological Cell Lysates
     Browse Sino Biological cDNA Clones
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
     Novus Tissue Slides
     EIF2B2 antibodies
     EIF2B2 proteins
     EIF2B2 lysates
     Antibodies for EIF2B2
     See all of Abcam's Antibodies, Kits and Proteins for EIF2B2
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins




     Proteins for EIF2B2
     Antibodies for EIF2B2
     ELISAs for EIF2B2
     CLIAs for EIF2B2
     Search LifeMap BioReagents cell lines for EIF2B2
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for EIF2B2
     SwitchGear 3'UTR luciferase reporter plasmids for EIF2B2
     SwitchGear Promoter luciferase reporter plasmids for EIF2B2
     ThermoFisher Antibodies for EIF2B2
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat EIF2B2
     inGenious Targeting Laboratory - Custom generated mouse model solutions for EIF2B2
     inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for EIF2B2
    Customized:
     lentivirus for stable overexpression of EIF2B2
     lentivirus expression plasmids for stable overexpression of EIF2B2
     adenovirus for overexpression of EIF2B2
     LSBio Antibodies in human, mouse, rat for EIF2B2
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
           
    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

    View Random Gene

    Category
    (GIFtS: 73)
    transforming growth factor, beta 1
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      EIF2B2 gene at Home site.
    hostname: 356977-web1.xennexinc.com index build: 106 solr: 1.4