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Aliases for EIF2AK4 Gene

Aliases for EIF2AK4 Gene

  • Eukaryotic Translation Initiation Factor 2 Alpha Kinase 4 2 3 5
  • GCN2-Like Protein 3 4
  • GCN2 3 4
  • Eukaryotic Translation Initiation Factor 2-Alpha Kinase 4 4
  • General Control Nonderepressible 2 3
  • GCN2 EIF2alpha Kinase 3
  • EC 2.7.11.1 4
  • KIAA1338 4
  • PVOD2 3

External Ids for EIF2AK4 Gene

Previous GeneCards Identifiers for EIF2AK4 Gene

  • GC15P033123
  • GC15P037805
  • GC15P037942
  • GC15P037962
  • GC15P038033
  • GC15P038014
  • GC15P040226
  • GC15P017070

Summaries for EIF2AK4 Gene

Entrez Gene Summary for EIF2AK4 Gene

  • This gene encodes a member of a family of kinases that phosphorylate the alpha subunit of eukaryotic translation initiation factor-2 (EIF2), resulting in the downregulaton of protein synthesis. The encoded protein responds to amino acid deprivation by binding uncharged transfer RNAs. It may also be activated by glucose deprivation and viral infection. Mutations in this gene have been found in individuals suffering from autosomal recessive pulmonary venoocclusive-disease-2. [provided by RefSeq, Mar 2014]

GeneCards Summary for EIF2AK4 Gene

EIF2AK4 (Eukaryotic Translation Initiation Factor 2 Alpha Kinase 4) is a Protein Coding gene. Diseases associated with EIF2AK4 include Pulmonary Venoocclusive Disease 2 and Pulmonary Venoocclusive Disease. Among its related pathways are Influenza A and Nanog in Mammalian ESC Pluripotency. GO annotations related to this gene include protein homodimerization activity and protein kinase activity. An important paralog of this gene is EIF2AK1.

UniProtKB/Swiss-Prot for EIF2AK4 Gene

  • Metabolic-stress sensing protein kinase that phosphorylates the alpha subunit of eukaryotic translation initiation factor 2 (eIF-2-alpha/EIF2S1) on Ser-52 in response to low amino acid availability (PubMed:25329545). Plays a role as an activator of the integrated stress response (ISR) required for adapatation to amino acid starvation. Converts phosphorylated eIF-2-alpha/EIF2S1 either to a competitive inhibitor of the translation initiation factor eIF-2B, leading to a global protein synthesis repression, and thus to a reduced overall utilization of amino acids, or to a translational initiation activation of specific mRNAs, such as the transcriptional activator ATF4, and hence allowing ATF4-mediated reprogramming of amino acid biosynthetic gene expression to alleviate nutrient depletion. Binds uncharged tRNAs (By similarity). Involved in cell cycle arrest by promoting cyclin D1 mRNA translation repression after the unfolded protein response pathway (UPR) activation or cell cycle inhibitor CDKN1A/p21 mRNA translation activation in response to amino acid deprivation (PubMed:26102367). Plays a role in the consolidation of synaptic plasticity, learning as well as formation of long-term memory. Plays a role in neurite outgrowth inhibition. Plays a proapoptotic role in response to glucose deprivation. Promotes global cellular protein synthesis repression in response to UV irradiation independently of the stress-activated protein kinase/c-Jun N-terminal kinase (SAPK/JNK) and p38 MAPK signaling pathways (By similarity).

  • (Microbial infection) Plays a role in modulating the adaptive immune response to yellow fever virus infection; promotes dendritic cells to initiate autophagy and antigene presentation to both CD4(+) and CD8(+) T cells under amino acid starvation (PubMed:24310610). Plays a role in the antiviral response against alphavirus infection; impairs early viral mRNA translation of the incoming genomic virus RNA, thus preventing alphavirus replication (By similarity).

Gene Wiki entry for EIF2AK4 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for EIF2AK4 Gene

Genomics for EIF2AK4 Gene

Regulatory Elements for EIF2AK4 Gene

Enhancers for EIF2AK4 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around EIF2AK4 on UCSC Golden Path with GeneCards custom track

Promoters for EIF2AK4 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around EIF2AK4 on UCSC Golden Path with GeneCards custom track

Genomic Location for EIF2AK4 Gene

Chromosome:
15
Start:
39,934,124 bp from pter
End:
40,035,596 bp from pter
Size:
101,473 bases
Orientation:
Plus strand

Genomic View for EIF2AK4 Gene

Genes around EIF2AK4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
EIF2AK4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for EIF2AK4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for EIF2AK4 Gene

Proteins for EIF2AK4 Gene

  • Protein details for EIF2AK4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9P2K8-E2AK4_HUMAN
    Recommended name:
    eIF-2-alpha kinase GCN2
    Protein Accession:
    Q9P2K8
    Secondary Accessions:
    • C9JEC4
    • Q69YL7
    • Q6DC97
    • Q96GN6
    • Q9H5K1
    • Q9NSQ3
    • Q9NSZ5
    • Q9UJ56

    Protein attributes for EIF2AK4 Gene

    Size:
    1649 amino acids
    Molecular mass:
    186911 Da
    Quaternary structure:
    • Homodimer; homodimerization is important for kinase activation by uncharged tRNAs. Interacts with GCN1; this interaction stimulates EIF2AK4/GCN2 kinase activity and is impaired by IMPACT upon a variety of stress conditions, such as amino acid depletion, UV-C irradiation, proteasome inhibitor treatment and glucose deprivation. Interacts with DNAJC3; this interaction inhibits EIF2AK4/GCN2 kinase activity during endoplasmic reticulum (ER), hypothermic and amino acid-starving stress conditions.
    SequenceCaution:
    • Sequence=BAA92576.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Sequence of unknown origin in the N-terminal part.; Evidence={ECO:0000305}; Sequence=BAB15625.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

    Alternative splice isoforms for EIF2AK4 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for EIF2AK4 Gene

Proteomics data for EIF2AK4 Gene at MOPED

Post-translational modifications for EIF2AK4 Gene

  • Autophosphorylated; autophosphorylation on Thr-899 is increased upon amino acid starvation and in UV irradiation cells and inhibited in presence of IMPACT.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for EIF2AK4 Gene

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for EIF2AK4 (GCN2)
  • Abcam antibodies for GCN2

No data available for DME Specific Peptides for EIF2AK4 Gene

Domains & Families for EIF2AK4 Gene

Gene Families for EIF2AK4 Gene

Suggested Antigen Peptide Sequences for EIF2AK4 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9P2K8

UniProtKB/Swiss-Prot:

E2AK4_HUMAN :
  • The histidyl-tRNA synthetase-like region and protein kinase domains are necessary for eIF-2-alpha kinase activity and eIF-2-alpha-mediated translational control. The histidyl-tRNA synthetase-like domain is necessary for binding to uncharged tRNAs. Kinase domain 1 is a degenerate kinase domain.
  • Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. GCN2 subfamily.
Domain:
  • The histidyl-tRNA synthetase-like region and protein kinase domains are necessary for eIF-2-alpha kinase activity and eIF-2-alpha-mediated translational control. The histidyl-tRNA synthetase-like domain is necessary for binding to uncharged tRNAs. Kinase domain 1 is a degenerate kinase domain.
  • Contains 2 protein kinase domains.
  • Contains 1 RWD domain.
Family:
  • Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. GCN2 subfamily.
genes like me logo Genes that share domains with EIF2AK4: view

Function for EIF2AK4 Gene

Molecular function for EIF2AK4 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
ATP + a protein = ADP + a phosphoprotein.
UniProtKB/Swiss-Prot Function:
Metabolic-stress sensing protein kinase that phosphorylates the alpha subunit of eukaryotic translation initiation factor 2 (eIF-2-alpha/EIF2S1) on Ser-52 in response to low amino acid availability (PubMed:25329545). Plays a role as an activator of the integrated stress response (ISR) required for adapatation to amino acid starvation. Converts phosphorylated eIF-2-alpha/EIF2S1 either to a competitive inhibitor of the translation initiation factor eIF-2B, leading to a global protein synthesis repression, and thus to a reduced overall utilization of amino acids, or to a translational initiation activation of specific mRNAs, such as the transcriptional activator ATF4, and hence allowing ATF4-mediated reprogramming of amino acid biosynthetic gene expression to alleviate nutrient depletion. Binds uncharged tRNAs (By similarity). Involved in cell cycle arrest by promoting cyclin D1 mRNA translation repression after the unfolded protein response pathway (UPR) activation or cell cycle inhibitor CDKN1A/p21 mRNA translation activation in response to amino acid deprivation (PubMed:26102367). Plays a role in the consolidation of synaptic plasticity, learning as well as formation of long-term memory. Plays a role in neurite outgrowth inhibition. Plays a proapoptotic role in response to glucose deprivation. Promotes global cellular protein synthesis repression in response to UV irradiation independently of the stress-activated protein kinase/c-Jun N-terminal kinase (SAPK/JNK) and p38 MAPK signaling pathways (By similarity).
UniProtKB/Swiss-Prot Function:
(Microbial infection) Plays a role in modulating the adaptive immune response to yellow fever virus infection; promotes dendritic cells to initiate autophagy and antigene presentation to both CD4(+) and CD8(+) T cells under amino acid starvation (PubMed:24310610). Plays a role in the antiviral response against alphavirus infection; impairs early viral mRNA translation of the incoming genomic virus RNA, thus preventing alphavirus replication (By similarity).

Enzyme Numbers (IUBMB) for EIF2AK4 Gene

Gene Ontology (GO) - Molecular Function for EIF2AK4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005524 ATP binding IEA --
genes like me logo Genes that share ontologies with EIF2AK4: view
genes like me logo Genes that share phenotypes with EIF2AK4: view

Human Phenotype Ontology for EIF2AK4 Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Models for EIF2AK4 Gene

MGI Knock Outs for EIF2AK4:

Animal Model Products

CRISPR Products

No data available for Transcription Factor Targets and HOMER Transcription for EIF2AK4 Gene

Localization for EIF2AK4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for EIF2AK4 Gene

Cytoplasm.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for EIF2AK4 Gene COMPARTMENTS Subcellular localization image for EIF2AK4 gene
Compartment Confidence
cytosol 5
nucleus 3
endoplasmic reticulum 2
vacuole 1

No data available for Gene Ontology (GO) - Cellular Components for EIF2AK4 Gene

Pathways & Interactions for EIF2AK4 Gene

genes like me logo Genes that share pathways with EIF2AK4: view

Pathways by source for EIF2AK4 Gene

1 Cell Signaling Technology pathway for EIF2AK4 Gene
1 GeneGo (Thomson Reuters) pathway for EIF2AK4 Gene
2 Qiagen pathways for EIF2AK4 Gene

SIGNOR curated interactions for EIF2AK4 Gene

Inactivates:

Gene Ontology (GO) - Biological Process for EIF2AK4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002250 adaptive immune response IEA --
GO:0002286 T cell activation involved in immune response ISS --
GO:0006446 regulation of translational initiation IEA,ISS --
GO:0007050 cell cycle arrest IEA --
GO:0007616 long-term memory ISS --
genes like me logo Genes that share ontologies with EIF2AK4: view

Drugs & Compounds for EIF2AK4 Gene

(7) Drugs for EIF2AK4 Gene - From: PharmGKB, HMDB, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Haloperidol Approved Pharma Antagonist Antipsychotic drug 136
Olanzapine Approved, Investigational Pharma Antagonist 380
Quetiapine Approved Pharma Antagonist 0
Risperidone Approved, Investigational Pharma Antagonist SR-2A inhibitor 477
Ziprasidone Approved Pharma Antagonist 140

(2) Additional Compounds for EIF2AK4 Gene - From: HMDB and Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
ADP
  • Adenosindiphosphorsaeure
  • Adenosine 5'-pyrophosphate
  • Adenosine diphosphate
  • Adenosine pyrophosphate
  • Adenosine-5'-diphosphate
Full agonist, Agonist 58-64-0
genes like me logo Genes that share compounds with EIF2AK4: view

Transcripts for EIF2AK4 Gene

Unigene Clusters for EIF2AK4 Gene

Eukaryotic translation initiation factor 2 alpha kinase 4:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for EIF2AK4 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14a · 14b ^ 15 ^ 16 ^ 17 ^ 18a · 18b ^ 19 ^ 20a · 20b ^ 21 ^
SP1: - - -
SP2: -
SP3:
SP4:
SP5:
SP6:
SP7:

ExUns: 22 ^ 23 ^ 24 ^ 25 ^ 26 ^ 27a · 27b ^ 28a · 28b ^ 29 ^ 30 ^ 31a · 31b ^ 32 ^ 33 ^ 34
SP1: -
SP2: -
SP3: - -
SP4: - - -
SP5:
SP6:
SP7: - -

Relevant External Links for EIF2AK4 Gene

GeneLoc Exon Structure for
EIF2AK4
ECgene alternative splicing isoforms for
EIF2AK4

Expression for EIF2AK4 Gene

mRNA expression in normal human tissues for EIF2AK4 Gene

Protein differential expression in normal tissues from HIPED for EIF2AK4 Gene

This gene is overexpressed in NK cells (44.2) and Breast (11.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for EIF2AK4 Gene



SOURCE GeneReport for Unigene cluster for EIF2AK4 Gene Hs.656673

mRNA Expression by UniProt/SwissProt for EIF2AK4 Gene

Q9P2K8-E2AK4_HUMAN
Tissue specificity: Widely expressed (PubMed:10504407). Expressed in lung, smooth muscle cells and macrophages (PubMed:24292273).
genes like me logo Genes that share expression patterns with EIF2AK4: view

Protein tissue co-expression partners for EIF2AK4 Gene

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for EIF2AK4 Gene

Orthologs for EIF2AK4 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for EIF2AK4 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia EIF2AK4 35
  • 91.55 (n)
  • 93.88 (a)
EIF2AK4 36
  • 94 (a)
OneToOne
dog
(Canis familiaris)
Mammalia EIF2AK4 35
  • 90.06 (n)
  • 91 (a)
EIF2AK4 36
  • 90 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Eif2ak4 35
  • 86.82 (n)
  • 90.51 (a)
Eif2ak4 16
Eif2ak4 36
  • 90 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia EIF2AK4 35
  • 99.72 (n)
  • 99.88 (a)
EIF2AK4 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Eif2ak4 35
  • 86.56 (n)
  • 90.58 (a)
oppossum
(Monodelphis domestica)
Mammalia EIF2AK4 36
  • 83 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia EIF2AK4 36
  • 76 (a)
OneToOne
chicken
(Gallus gallus)
Aves EIF2AK4 35
  • 71.58 (n)
  • 73.51 (a)
EIF2AK4 36
  • 72 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia EIF2AK4 36
  • 74 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia eif2ak4 35
  • 68.61 (n)
  • 69.27 (a)
zebrafish
(Danio rerio)
Actinopterygii eif2ak4 35
  • 63.01 (n)
  • 62.94 (a)
eif2ak4 36
  • 64 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP012368 35
  • 24.31 (n)
  • 6.4 (a)
fruit fly
(Drosophila melanogaster)
Insecta Gcn2 35
  • 45.78 (n)
  • 35.67 (a)
Gcn2 36
  • 33 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea gcn-2 35
  • 44.87 (n)
  • 31.79 (a)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AAL083W 35
  • 45.53 (n)
  • 33.98 (a)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0C10802g 35
  • 44.06 (n)
  • 32.02 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes GCN2 35
  • 43.75 (n)
  • 31.83 (a)
GCN2 36
  • 24 (a)
OneToMany
GCN2 38
bread mold
(Neurospora crassa)
Ascomycetes NCU01187 35
  • 44.52 (n)
  • 32.52 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes gcn2 35
  • 43.18 (n)
  • 32.4 (a)
Species with no ortholog for EIF2AK4:
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for EIF2AK4 Gene

ENSEMBL:
Gene Tree for EIF2AK4 (if available)
TreeFam:
Gene Tree for EIF2AK4 (if available)

Paralogs for EIF2AK4 Gene

Paralogs for EIF2AK4 Gene

(1) SIMAP similar genes for EIF2AK4 Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with EIF2AK4: view

Variants for EIF2AK4 Gene

Sequence variations from dbSNP and Humsavar for EIF2AK4 Gene

SNP ID Clin Chr 15 pos Sequence Context AA Info Type
VAR_040479 -
rs34439704 - 39,949,251(+) CCAAG(C/T)GGAAA reference, missense
rs2291627 - 39,967,647(-) CGTAA(G/T)CTTGA reference, missense
VAR_040482 -
VAR_040483 A lung neuroendocrine carcinoma sample

Structural Variations from Database of Genomic Variants (DGV) for EIF2AK4 Gene

Variant ID Type Subtype PubMed ID
nsv832983 CNV Gain 17160897
nsv1503 CNV Insertion 18451855
nsv516913 CNV Loss 19592680

Variation tolerance for EIF2AK4 Gene

Residual Variation Intolerance Score: 39% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 10.09; 90.21% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for EIF2AK4 Gene

Human Gene Mutation Database (HGMD)
EIF2AK4

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for EIF2AK4 Gene

Disorders for EIF2AK4 Gene

MalaCards: The human disease database

(7) MalaCards diseases for EIF2AK4 Gene - From: OMIM, ClinVar, GeneTests, Orphanet, Swiss-Prot, DISEASES, and GeneCards

Disorder Aliases PubMed IDs
pulmonary venoocclusive disease 2
  • hemangiomatosis, familial pulmonary capillary
pulmonary venoocclusive disease
  • pulmonary veno-occlusive disease
pulmonary capillary hemangiomatosis
yellow fever
  • jungle yellow fever
heritable pulmonary arterial hypertension
  • familial primary pulmonary hypertension
- elite association - COSMIC cancer census association via MalaCards

UniProtKB/Swiss-Prot

E2AK4_HUMAN
  • Pulmonary venoocclusive disease 2, autosomal recessive (PVOD2) [MIM:234810]: A disease characterized by widespread fibrous obstruction and intimal thickening of septal veins and preseptal venules, a low diffusing capacity for carbon monoxide, occult alveolar hemorrhage, and nodular ground-glass opacities, septal lines and lymph node enlargement showed by high-resolution computed tomography of the chest. It is frequently associated with pulmonary capillary dilatation and proliferation, and is a rare and devastating cause of pulmonary hypertension. {ECO:0000269 PubMed:24135949, ECO:0000269 PubMed:24292273}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Relevant External Links for EIF2AK4

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
EIF2AK4
genes like me logo Genes that share disorders with EIF2AK4: view

No data available for Genatlas for EIF2AK4 Gene

Publications for EIF2AK4 Gene

  1. Characterization of a mammalian homolog of the GCN2 eukaryotic initiation factor 2alpha kinase. (PMID: 10504407) Berlanga J.J. … de Haro C. (Eur. J. Biochem. 1999) 2 3 4 23 67
  2. Autophagy impairment stimulates PS1 expression and gamma-secretase activity. (PMID: 20168091) Ohta K. … Nakagawa T. (Autophagy 2010) 3 23
  3. Systems biology approach predicts immunogenicity of the yellow fever vaccine in humans. (PMID: 19029902) Querec T.D. … Pulendran B. (Nat. Immunol. 2009) 3 23
  4. The role of nitric-oxide synthase in the regulation of UVB light-induced phosphorylation of the alpha subunit of eukaryotic initiation factor 2. (PMID: 19586904) Lu W. … Wu S. (J. Biol. Chem. 2009) 3 23
  5. p58IPK is an inhibitor of the eIF2I+ kinase GCN2 and its localization and expression underpin protein synthesis and ER processing capacity. (PMID: 25329545) Roobol A. … Smales C.M. (Biochem. J. 2015) 3

Products for EIF2AK4 Gene

Sources for EIF2AK4 Gene

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