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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

EIF2AK4 Gene

protein-coding   GIFtS: 61
GCID: GC15P040226

Eukaryotic Translation Initiation Factor 2 Alpha Kinase...

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Eukaryotic Translation Initiation Factor 2 Alpha Kinase 41 2     GCN2 EIF2alpha Kinase2
GCN22 3     EC 2.7.11.13
GCN2-Like Protein2 3     KIAA13383
Eukaryotic Translation Initiation Factor 2-Alpha Kinase 42     

External Ids:    HGNC: 196871   Entrez Gene: 4402752   Ensembl: ENSG000001288297   OMIM: 6092805   UniProtKB: Q9P2K83   

Export aliases for EIF2AK4 gene to outside databases

Previous GC identifers: GC15P033123 GC15P037805 GC15P037942 GC15P037962 GC15P038033 GC15P038014 GC15P017070


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for EIF2AK4 Gene:
EIF2AK4 belongs to a family of kinases that phosphorylate the alpha subunit of eukaryotic translation initiation
factor-2 (EIF2S1; MIM 603907) to downregulate protein synthesis in response to varied cellular stresses (Berlanga
et al., 1999 (PubMed 10504407)).(supplied by OMIM, Mar 2008)

GeneCards Summary for EIF2AK4 Gene: 
EIF2AK4 (eukaryotic translation initiation factor 2 alpha kinase 4) is a protein-coding gene. Diseases associated with EIF2AK4 include skin papilloma, and yellow fever, and among its related super-pathways are Influenza A and Nanog in Mammalian ESC Pluripotency. GO annotations related to this gene include tRNA binding and protein homodimerization activity. An important paralog of this gene is EIF2AK1.

UniProtKB/Swiss-Prot: E2AK4_HUMAN, Q9P2K8
Function: Can phosphorylate the alpha subunit of EIF2 and may mediate translational control (By similarity)

Gene Wiki entry for EIF2AK4 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000015.9  NT_010194.17  NC_018926.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the EIF2AK4 gene promoter:
         CREB   p53   deltaCREB   NF-kappaB1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidEIF2AK4 promoter sequence
   Search SABiosciences Chromatin IP Primers for EIF2AK4

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat EIF2AK4


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 15q15.1   Ensembl cytogenetic band:  15q15.1   HGNC cytogenetic band: 15q13.3

EIF2AK4 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
EIF2AK4 gene location

GeneLoc information about chromosome 15         GeneLoc Exon Structure

GeneLoc location for GC15P040226:  view genomic region     (about GC identifiers)

Start:
40,226,347 bp from pter      End:
40,327,797 bp from pter
Size:
101,451 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: E2AK4_HUMAN, Q9P2K8 (See protein sequence)
Recommended Name: Eukaryotic translation initiation factor 2-alpha kinase 4  
Size: 1649 amino acids; 186911 Da
Sequence caution: Sequence=BAA92576.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Sequence of
unknown origin in the N-terminal part; Sequence=BAB15625.1; Type=Erroneous initiation; Note=Translation
N-terminally extended;
Secondary accessions: C9JEC4 Q69YL7 Q6DC97 Q96GN6 Q9H5K1 Q9NSQ3 Q9NSZ5 Q9UJ56
Alternative splicing: 3 isoforms:  Q9P2K8-1   Q9P2K8-2   Q9P2K8-3   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for EIF2AK4: NX_Q9P2K8

Explore proteomics data for EIF2AK4 at MOPED 

Post-translational modifications:

  • UniProtKB: Autophosphorylated on threonine residues (By similarity)
  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q9P2K8

  • EIF2AK4 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    EIF2AK4 Protein Expression
    REFSEQ proteins: NP_001013725.2  
    ENSEMBL proteins: 
     ENSP00000453148   ENSP00000263791   ENSP00000453968   ENSP00000453575   ENSP00000454210  
     ENSP00000372174  

    Human Recombinant Protein Products for EIF2AK4: 
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    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Browse Proteins at Cloud-Clone Corp. 

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005622intracellular NAS--
    GO:0022626cytosolic ribosome ISS--

    EIF2AK4 for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    IUPHAR Guide to PHARMACOLOGY protein family classification: eukaryotic translation initiation factor 2 alpha kinase 4 
    GCN2 subfamily

    5/10 InterPro protein domains (see all 10):
     IPR016135 UBQ-conjugating_enzyme/RWD
     IPR017441 Protein_kinase_ATP_BS
     IPR011009 Kinase-like_dom
     IPR008271 Ser/Thr_kinase_AS
     IPR026920 EIF2AK4

    Graphical View of Domain Structure for InterPro Entry Q9P2K8

    ProtoNet protein and cluster: Q9P2K8

    2 Blocks protein domains:
    IPB000608 Ubiquitin-conjugating enzymes
    IPB006575 RWD


    UniProtKB/Swiss-Prot: E2AK4_HUMAN, Q9P2K8
    Domain: Kinase domain 1 is a degenerate kinase domain
    Domain: RWD domain is reported to interact with GCN1L1
    Similarity: Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. GCN2 subfamily
    Similarity: Contains 2 protein kinase domains
    Similarity: Contains 1 RWD domain


    EIF2AK4 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: E2AK4_HUMAN, Q9P2K8
    Function: Can phosphorylate the alpha subunit of EIF2 and may mediate translational control (By similarity)
    Catalytic activity: ATP + a protein = ADP + a phosphoprotein

         Enzyme Number (IUBMB): EC 2.7.11.11

         Gene Ontology (GO): 5/8 molecular function terms (GO ID links to tree view) (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004672protein kinase activity ----
    GO:0004674protein serine/threonine kinase activity ISS--
    GO:0004694eukaryotic translation initiation factor 2alpha kinase activity ISS--
    GO:0004713protein tyrosine kinase activity ----
    GO:0005515protein binding ----
         
    EIF2AK4 for ontologies           About GeneDecksing


    Phenotypes:
         5 GenomeRNAi human phenotypes for EIF2AK4:
     Decreased substrate adherent c  Decreased telomerase activity  Increased apoptosis  Increased cell death HMECs cel 
     Increased number of small and  

         10 MGI mutant phenotypes (inferred from 4 alleles(MGI details for Eif2ak4):
     behavior/neurological  growth/size  homeostasis/metabolism  immune system  liver/biliary system 
     mortality/aging  muscle  nervous system  other  reproductive system 

    EIF2AK4 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-outs for EIF2AK4: Eif2ak4tm1Drc Eif2ak4tm1.2Dron

       inGenious Targeting Laboratory - Custom generated mouse model solutions for EIF2AK4 
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for EIF2AK4 
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    SwitchGear 3'UTR luciferase reporter plasmidEIF2AK4 3' UTR sequence
    Inhib. RNA
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for EIF2AK4 About   (see all 8)                                                                                              See pathways by source

    SuperPathContained pathways About
    1Influenza A
    Influenza A0.34
    Herpes simplex infection0.33
    Measles0.34
    2Nanog in Mammalian ESC Pluripotency
    GSK3 Signaling0.61
    3Apoptotic Pathways in Synovial Fibroblasts
    eIF2 Pathway0.60
    4Translation Insulin regulation of translation
    Translation Regulation activity of EIF20.47
    5Protein processing in endoplasmic reticulum
    Protein processing in endoplasmic reticulum

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 EMD Millipore Pathway for EIF2AK4
        Translation Regulation activity of EIF2

    2 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for EIF2AK4
        GSK3 Signaling
    eIF2 Pathway

    1 Cell Signaling Technology (CST) Pathway for EIF2AK4
        Translational Control

    1 GeneGo (Thomson Reuters) Pathway for EIF2AK4
        Translation Regulation of EIF2 activity


    5/6         Kegg Pathways  (Kegg details for EIF2AK4) (see all 6):
        Protein processing in endoplasmic reticulum
    Hepatitis C
    Measles
    Influenza A
    Herpes simplex infection


    EIF2AK4 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for EIF2AK4

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/118 Interacting proteins for EIF2AK4 (Q9P2K83 ENSP000002637914) via UniProtKB, MINT, STRING, and/or I2D (see all 118)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    EEF1A1P681043, ENSP000003300544I2D: score=3 STRING: ENSP00000330054
    EIF2S1P051983, ENSP000002563834I2D: score=2 STRING: ENSP00000256383
    EIF2B5Q131443, ENSP000002737834I2D: score=1 STRING: ENSP00000273783
    EIF5P550103, ENSP000002165544I2D: score=1 STRING: ENSP00000216554
    USP46P620683, ENSP000004078184I2D: score=2 STRING: ENSP00000407818
    About this table

    Gene Ontology (GO): 5/6 biological process terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006446regulation of translational initiation ISS--
    GO:0006468protein phosphorylation ISS--
    GO:0009267cellular response to starvation IEA--
    GO:0017148negative regulation of translation IEA--
    GO:0030968endoplasmic reticulum unfolded protein response IEA--

    EIF2AK4 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    EIF2AK4 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
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    Browse Tocris compounds for EIF2AK4 (E2AK4)

    2 HMDB Compounds for EIF2AK4    About this table
    CompoundSynonyms CAS #PubMed Ids
    ADPadenosindiphosphorsaeure (see all 8)58-64-0--
    Adenosine triphosphate5'-(tetrahydrogen triphosphate) Adenosine (see all 24)56-65-5--

    2 Novoseek inferred chemical compound relationships for EIF2AK4 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    trna 48.1 14 7623840 (5), 10983975 (4), 15964839 (2)
    histidine 17.3 3 7623840 (2), 16215176 (1)

    Search CenterWatch for drugs/clinical trials and news about EIF2AK4 / E2AK4

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for EIF2AK4 gene: 
    NM_001013703.2  

    Unigene Cluster for EIF2AK4:

    Eukaryotic translation initiation factor 2 alpha kinase 4
    Hs.656673  [show with all ESTs]
    Unigene Representative Sequence: NM_001013703
    11 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000559624(uc001zkl.3) ENST00000263791(uc001zkm.1) ENST00000560648
    ENST00000560855 ENST00000558629(uc001zkn.1) ENST00000559311 ENST00000558557(uc001zko.1)
    ENST00000558743 ENST00000559032 ENST00000558823 ENST00000382727(uc010bbj.1 uc010bbk.1)

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    Additional mRNA sequence: 

    AB037759.1 AJ243428.1 AK027011.1 AK074361.1 AL137627.1 AL137676.1 AL157497.1 AL832907.1 
    BC009350.2 BC014915.1 BC061591.1 BC078179.1 

    16 DOTS entries:

    DT.414488  DT.100779167  DT.100779169  DT.436676  DT.97839406  DT.121073701  DT.305838  DT.100703012 
    DT.101964269  DT.95373012  DT.100009816  DT.121073761  DT.121073784  DT.97774332  DT.75123529  DT.92053714 

    24/178 AceView cDNA sequences (see all 178):

    AL157497 BU501036 CR605057 BX279858 BQ641337 AA011327 BM449754 BU634471 
    AL832907 AA370461 AA159551 AW069882 BQ951986 AL137627 BC009350 H65305 
    BM765688 BC014915 BU528422 BM463412 AA423963 BX419551 BQ950911 BG108100 

    GeneLoc Exon Structure

    5/7 Alternative Splicing Database (ASD) splice patterns (SP) for EIF2AK4 (see all 7)    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14a · 14b ^ 15 ^ 16 ^ 17 ^ 18a · 18b ^ 19 ^ 20a · 20b ^ 21 ^
    SP1:                                                  -                                         -                             -                                 
    SP2:                                                                                                                          -                                 
    SP3:                                                                                                                                                            
    SP4:                                                                                                                                                            
    SP5:                                                                                                                                                            

    ExUns: 22 ^ 23 ^ 24 ^ 25 ^ 26 ^ 27a · 27b ^ 28a · 28b ^ 29 ^ 30 ^ 31a · 31b ^ 32 ^ 33 ^ 34
    SP1:                                -                                                               
    SP2:                                -                                                               
    SP3:              -                 -                                                               
    SP4:                                -                       -                       -               
    SP5:                                                                                                


    ECgene alternative splicing isoforms for EIF2AK4

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    EIF2AK4 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TGTAATATAT
    EIF2AK4 Expression
    About this image


    See EIF2AK4 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for EIF2AK4

    SOURCE GeneReport for Unigene cluster: Hs.656673

    UniProtKB/Swiss-Prot: E2AK4_HUMAN, Q9P2K8
    Tissue specificity: Widely expressed

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals and fungi.

    Orthologs for EIF2AK4 gene from 7/17 species (see all 17)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Eif2ak41 , 5 eukaryotic translation initiation factor 2 alpha kinase more1, 5 86.87(n)1
    90.65(a)1
      2 (59.40 cM)5
    271031  NM_013719.31  NP_038747.21 
     1183886185 
    chicken
    (Gallus gallus)
    Aves EIF2AK41 eukaryotic translation initiation factor 2 alpha kinase more 71.33(n)
    73.29(a)
      423285  XM_421203.3  XP_421203.2 
    lizard
    (Anolis carolinensis)
    Reptilia EIF2AK46
    Uncharacterized protein
    74(a)
    1 ↔ 1
    GL343264.1(1719050-1775713)
    zebrafish
    (Danio rerio)
    Actinopterygii eif2ak41 eukaryotic translation initiation factor 2 alpha kinase more 63.07(n)
    63.11(a)
      100149925  XM_002667103.2  XP_002667149.2 
    fruit fly
    (Drosophila melanogaster)
    Insecta Gcn21 CG1609-PA 46.53(n)
    36.38(a)
      43709  NM_057882.3  NP_477230.1 
    worm
    (Caenorhabditis elegans)
    Secernentea gcn-21 Protein GCN-2 42.94(n)
    29.52(a)
      174953  NM_064380.2  NP_496781.1 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes GCN2(YDR283C)4
    GCN21
    Protein kinase, phosphorylates the alpha-subunit of more4
    Gcn2p1
    42.12(n)1
    28.91(a)1
      4(1030049-1025070)4
    8518771, 4  NP_010569.31  NP_010569.14 


    ENSEMBL Gene Tree for EIF2AK4 (if available)
    TreeFam Gene Tree for EIF2AK4 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for EIF2AK4 gene
    EIF2AK12  EIF2AK32  EIF2AK22  
    1 SIMAP similar gene for EIF2AK4 using alignment to 4 protein entries:     E2AK4_HUMAN (see all proteins):
    NUAK1

    EIF2AK4 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/2262 SNPs in EIF2AK4 are shown (see all 2262)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 15 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0404834
    A lung neuroendocrine carcinoma sample4--see VAR_0404832 H Y mis40--------
    VAR_0404824
    ----see VAR_0404822 D V mis40--------
    VAR_0404794
    ----see VAR_0404792 H R mis40--------
    VAR_0404844
    ----see VAR_0404842 T R mis40--------
    rs763708521,2
    C,F--40224528(+) TAGAGA/TTATAT 1 -- us2k11Minor allele frequency- T:0.03EA 120
    rs1164359621,2
    C,F--40224690(+) TGACAT/GTTTCA 1 -- us2k11Minor allele frequency- G:0.03WA 118
    rs1444347731,2
    --40224713(+) TAAAAG/TAATTT 1 -- us2k10--------
    rs1824983901,2
    --40224799(+) TACTCG/TGGCTG 1 -- us2k10--------
    rs1883193231,2
    --40224825(+) CTTAAC/TGTGGG 1 -- us2k10--------
    rs1396058861,2
    --40224920(+) CAATGC/GGTTAG 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for EIF2AK4 (40226347 - 40327797 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 3 variations for EIF2AK4:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv1503CNV Insertion18451855
    nsv516913CNV Loss19592680
    nsv832983CNV Gain17160897

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 609280    OMIM disorders: --

    16 diseases for EIF2AK4:    About MalaCards
    skin papilloma    yellow fever    severe acute respiratory syndrome    papilloma
    measles    multiple myeloma    influenza    myeloma
    ischemia    hepatitis c    hypoxia    retinitis
    sarcoma    colon cancer    hepatitis    pancreatitis


    EIF2AK4 for disorders           About GeneDecksing


    Export disorders for EIF2AK4 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for EIF2AK4 gene, integrated from 9 sources (see all 71):
    (articles sorted by number of sources associating them with EIF2AK4)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Characterization of a mammalian homolog of the GCN2 eukaryotic initiation factor 2alpha kinase. (PubMed id 10504407)1, 2, 3, 9 Berlanga J.J.... de Haro C. (1999)
    2. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)1, 2 Olsen J.V....Mann M. (2006)
    3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    5. Prediction of the coding sequences of unidentified human genes. XVI. The complete sequences of 150 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 10718198)1, 2 Nagase T.... Ohara O. (2000)
    6. The role of nitric-oxide synthase in the regulation o f UVB light-induced phosphorylation of the alpha subunit of eukaryotic initiati on factor 2. (PubMed id 19586904)1, 9 Lu W....Wu S. (2009)
    7. Autophagy impairment stimulates PS1 expression and ga mma-secretase activity. (PubMed id 20168091)1, 9 Ohta K....Nakagawa T. (2010)
    8. Activation of GCN2 upon HIV-1 infection and inhibition of translation. (PubMed id 23417324)1 Cosnefroy O....Andreola M.L. (2013)
    9. Amino acid sensing in dietary-restriction-mediated lon gevity: roles of signal-transducing kinases GCN2 and TOR. (PubMed id 23216249)1 Gallinetti J....Mitchell J.R. (2013)
    10. Tryptophan depletion and the kinase GCN2 mediate IFN-g -induced autophagy. (PubMed id 22896630)1 Fougeray S....Pallet N. (2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 440275 HGNC: 19687 AceView: LOC440275 Ensembl:ENSG00000128829 euGenes: HUgn440275
    ECgene: EIF2AK4 Kegg: 440275 H-InvDB: EIF2AK4

    (According to HUGE)
    About This Section
    HUGE: KIAA1338

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for EIF2AK4 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for EIF2AK4 gene:
    Search GeneIP for patents involving EIF2AK4

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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