Aliases for EIF2AK4 Gene
External Ids for EIF2AK4 Gene
Previous GeneCards Identifiers for EIF2AK4 Gene
This gene encodes a member of a family of kinases that phosphorylate the alpha subunit of eukaryotic translation initiation factor-2 (EIF2), resulting in the downregulaton of protein synthesis. The encoded protein responds to amino acid deprivation by binding uncharged transfer RNAs. It may also be activated by glucose deprivation and viral infection. Mutations in this gene have been found in individuals suffering from autosomal recessive pulmonary venoocclusive-disease-2. [provided by RefSeq, Mar 2014]
GeneCards Summary for EIF2AK4 Gene
EIF2AK4 (Eukaryotic Translation Initiation Factor 2 Alpha Kinase 4) is a Protein Coding gene. Diseases associated with EIF2AK4 include pulmonary capillary hemangiomatosis and pulmonary venoocclusive disease. Among its related pathways are Apoptotic Pathways in Synovial Fibroblasts and Nanog in Mammalian ESC Pluripotency. GO annotations related to this gene include protein homodimerization activity and protein kinase activity. An important paralog of this gene is EIF2AK1.
UniProtKB/Swiss-Prot for EIF2AK4 Gene
Can phosphorylate the alpha subunit of EIF2 and may mediate translational control.