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Aliases for EIF2AK2 Gene

Aliases for EIF2AK2 Gene

  • Eukaryotic Translation Initiation Factor 2 Alpha Kinase 2 2 3 5
  • Protein Kinase, Interferon-Inducible Double Stranded RNA Dependent 2 3
  • Protein Phosphatase 1, Regulatory Subunit 83 2 3
  • Tyrosine-Protein Kinase EIF2AK2 3 4
  • P1/EIF-2A Protein Kinase 3 4
  • EIF-2A Protein Kinase 2 3 4
  • Protein Kinase R 3 4
  • P68 Kinase 3 4
  • PRKR 3 4
  • PKR 3 4
  • Interferon-Induced, Double-Stranded RNA-Activated Protein Kinase 3
  • Eukaryotic Translation Initiation Factor 2-Alpha Kinase 2 4
  • Interferon-Inducible RNA-Dependent Protein Kinase 4
  • Double Stranded RNA Activated Protein Kinase 3
  • Interferon-Inducible ElF2alpha Kinase 3
  • Protein Kinase RNA-Activated 4
  • EC 2.7.11.1 4
  • EC 2.7.10.2 4
  • EIF2AK1 3
  • PPP1R83 3

External Ids for EIF2AK2 Gene

Previous HGNC Symbols for EIF2AK2 Gene

  • PRKR

Previous GeneCards Identifiers for EIF2AK2 Gene

  • GC02M037246
  • GC02M037326

Summaries for EIF2AK2 Gene

Entrez Gene Summary for EIF2AK2 Gene

  • The protein encoded by this gene is a serine/threonine protein kinase that is activated by autophosphorylation after binding to dsRNA. The activated form of the encoded protein can phosphorylate translation initiation factor EIF2S1, which in turn inhibits protein synthesis. This protein is also activated by manganese ions and heparin. Three transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Oct 2011]

GeneCards Summary for EIF2AK2 Gene

EIF2AK2 (Eukaryotic Translation Initiation Factor 2 Alpha Kinase 2) is a Protein Coding gene. Diseases associated with EIF2AK2 include Herpes Simplex and Hepatitis C. Among its related pathways are Type II interferon signaling (IFNG) and Protein processing in endoplasmic reticulum. GO annotations related to this gene include poly(A) RNA binding and protein kinase activity. An important paralog of this gene is EIF2AK3.

UniProtKB/Swiss-Prot for EIF2AK2 Gene

  • IFN-induced dsRNA-dependent serine/threonine-protein kinase which plays a key role in the innate immune response to viral infection and is also involved in the regulation of signal transduction, apoptosis, cell proliferation and differentiation. Exerts its antiviral activity on a wide range of DNA and RNA viruses including hepatitis C virus (HCV), hepatitis B virus (HBV), measles virus (MV) and herpes simplex virus 1 (HHV-1). Inhibits viral replication via phosphorylation of the alpha subunit of eukaryotic initiation factor 2 (EIF2S1), this phosphorylation impairs the recycling of EIF2S1 between successive rounds of initiation leading to inhibition of translation which eventually results in shutdown of cellular and viral protein synthesis. Also phosphorylates other substrates including p53/TP53, PPP2R5A, DHX9, ILF3, IRS1 and the HHV-1 viral protein US11. In addition to serine/threonine-protein kinase activity, also has tyrosine-protein kinase activity and phosphorylates CDK1 at Tyr-4 upon DNA damage, facilitating its ubiquitination and proteosomal degradation. Either as an adapter protein and/or via its kinase activity, can regulate various signaling pathways (p38 MAP kinase, NF-kappa-B and insulin signaling pathways) and transcription factors (JUN, STAT1, STAT3, IRF1, ATF3) involved in the expression of genes encoding proinflammatory cytokines and IFNs. Activates the NF-kappa-B pathway via interaction with IKBKB and TRAF family of proteins and activates the p38 MAP kinase pathway via interaction with MAP2K6. Can act as both a positive and negative regulator of the insulin signaling pathway (ISP). Negatively regulates ISP by inducing the inhibitory phosphorylation of insulin receptor substrate 1 (IRS1) at Ser-312 and positively regulates ISP via phosphorylation of PPP2R5A which activates FOXO1, which in turn up-regulates the expression of insulin receptor substrate 2 (IRS2). Can regulate NLRP3 inflammasome assembly and the activation of NLRP3, NLRP1, AIM2 and NLRC4 inflammasomes. Can trigger apoptosis via FADD-mediated activation of CASP8. Plays a role in the regulation of the cytoskeleton by binding to gelsolin (GSN), sequestering the protein in an inactive conformation away from actin.

Gene Wiki entry for EIF2AK2 Gene

Additional gene information for EIF2AK2 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for EIF2AK2 Gene

Genomics for EIF2AK2 Gene

Regulatory Elements for EIF2AK2 Gene

Enhancers for EIF2AK2 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH02H037189 1.4 Ensembl ENCODE dbSUPER 16.6 -33.0 -33047 1 ELF3 FOXA2 ARID4B RAD21 RARA SLC30A9 SCRT2 FOS MIXL1 THAP11 EIF2AK2 NDUFAF7 CEBPZOS CEBPZ RPL31P16
GH02H037181 1.2 Ensembl ENCODE dbSUPER 18 -24.8 -24818 1 HDAC1 JUN ZBTB40 FOSL1 GATA3 ZNF316 GATA2 NFE2 MAFK SMARCE1 NDUFAF7 EIF2AK2 CEBPZOS CEBPZ RNU6-939P SULT6B1 PRKD3 RPL31P16
GH02H037195 1.3 ENCODE dbSUPER 11.6 -41.3 -41325 5 PKNOX1 FOXA2 ZFP64 ARID4B SIN3A DMAP1 YY1 ZNF766 PAF1 SP3 CEBPZOS CEBPZ NDUFAF7 EIF2AK2 SULT6B1 ENSG00000272054
GH02H037154 1 ENCODE 13.8 +0.5 545 3 HDGF PKNOX1 ARID4B SIN3A DMAP1 BRCA1 ZNF766 SP3 SP5 REST NDUFAF7 EIF2AK2 RPL31P16 CEBPZOS SULT6B1 CEBPZ ENSG00000224891
GH02H037204 0.9 ENCODE dbSUPER 11.6 -48.9 -48869 3 FOXA2 MAX POLR2A ADNP POU5F1 KDM1A ZBTB33 SETDB1 CEBPZOS CEBPZ NDUFAF7 EIF2AK2 ENSG00000272054 SULT6B1
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around EIF2AK2 on UCSC Golden Path with GeneCards custom track

Promoters for EIF2AK2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000115319 265 1201 ARID4B DMAP1 BRCA1 ZNF766 SP3 SP5 REST KAT8 NFIL3 MXD3

Transcription factor binding sites by QIAGEN in the EIF2AK2 gene promoter:

Genomic Location for EIF2AK2 Gene

Chromosome:
2
Start:
37,099,210 bp from pter
End:
37,157,065 bp from pter
Size:
57,856 bases
Orientation:
Minus strand

Genomic View for EIF2AK2 Gene

Genes around EIF2AK2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
EIF2AK2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for EIF2AK2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for EIF2AK2 Gene

Proteins for EIF2AK2 Gene

  • Protein details for EIF2AK2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P19525-E2AK2_HUMAN
    Recommended name:
    Interferon-induced, double-stranded RNA-activated protein kinase
    Protein Accession:
    P19525
    Secondary Accessions:
    • A8K3P0
    • D6W584
    • E9PC80
    • Q52M43
    • Q7Z6F6
    • Q9UIR4

    Protein attributes for EIF2AK2 Gene

    Size:
    551 amino acids
    Molecular mass:
    62094 Da
    Quaternary structure:
    • Homodimer. Interacts with STRBP (By similarity). Interacts with DNAJC3. Forms a complex with FANCA, FANCC, FANCG and HSP70. Interacts with ADAR/ADAR1. Interacts with IRS1 (By similarity). The inactive form interacts with NCK1 and GSN. Interacts (via the kinase catalytic domain) with STAT3 (via SH2 domain), TRAF2 (C-terminus), TRAF5 (C-terminus) and TRAF6 (C-terminus). Interacts with MAP2K6, IKBKB/IKKB, NPM1, TARBP2, NLRP1, NLRP3, NLRC4 and AIM2. Interacts (via DRBM 1 domain) with DUS2L (via DRBM domain). Interacts with DHX9 (via N-terminus) and this interaction is dependent upon activation of the kinase.
    • (Microbial infection) Interacts with human herpes simplex virus 1 (HHV-1) protein US11 in an RNA-dependent manner (PubMed:11836380). The inactive form interacts with Toscana virus (TOS) NSS (PubMed:23325696). Interacts with herpes virus 8 protein v-IRF2; this interaction inhibits EIF2AK2 activation (PubMed:11160738). Interacts with vaccinia protein E3 (PubMed:25740987).

    Three dimensional structures from OCA and Proteopedia for EIF2AK2 Gene

    Alternative splice isoforms for EIF2AK2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for EIF2AK2 Gene

Post-translational modifications for EIF2AK2 Gene

  • Autophosphorylated on several Ser, Thr and Tyr residues. Autophosphorylation of Thr-451 is dependent on Thr-446 and is stimulated by dsRNA binding and dimerization. Autophosphorylation apparently leads to the activation of the kinase. Tyrosine autophosphorylation is essential for efficient dsRNA-binding, dimerization, and kinase activation.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for EIF2AK2 (PKR)
  • Abcam antibodies for EIF2AK2

No data available for DME Specific Peptides for EIF2AK2 Gene

Domains & Families for EIF2AK2 Gene

Gene Families for EIF2AK2 Gene

Suggested Antigen Peptide Sequences for EIF2AK2 Gene

Graphical View of Domain Structure for InterPro Entry

P19525

UniProtKB/Swiss-Prot:

E2AK2_HUMAN :
  • Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. GCN2 subfamily.
Family:
  • Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. GCN2 subfamily.
genes like me logo Genes that share domains with EIF2AK2: view

Function for EIF2AK2 Gene

Molecular function for EIF2AK2 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
ATP + a protein = ADP + a phosphoprotein.
UniProtKB/Swiss-Prot CatalyticActivity:
ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.
UniProtKB/Swiss-Prot EnzymeRegulation:
Initially produced in an inactive form and is activated by binding to viral dsRNA, which causes dimerization and autophosphorylation in the activation loop and stimulation of function. ISGylation can activate it in the absence of viral infection. Can also be activated by heparin, proinflammatory stimuli, growth factors, cytokines, oxidative stress and the cellular protein PRKRA. Activity is markedly stimulated by manganese ions. Activation is blocked by the viral components HIV-1 Tat protein and large amounts of HIV-1 trans-activation response (TAR) RNA element as well as by the cellular proteins TARBP2, DUS2L, NPM1, NCK1 and ADAR. Down-regulated by Toscana virus (TOS) and Rift valley fever virus (RVFV) NSS which promote its proteasomal degradation. Inhibited by vaccinia virus protein E3, probably via dsRNA sequestering.
UniProtKB/Swiss-Prot Function:
IFN-induced dsRNA-dependent serine/threonine-protein kinase which plays a key role in the innate immune response to viral infection and is also involved in the regulation of signal transduction, apoptosis, cell proliferation and differentiation. Exerts its antiviral activity on a wide range of DNA and RNA viruses including hepatitis C virus (HCV), hepatitis B virus (HBV), measles virus (MV) and herpes simplex virus 1 (HHV-1). Inhibits viral replication via phosphorylation of the alpha subunit of eukaryotic initiation factor 2 (EIF2S1), this phosphorylation impairs the recycling of EIF2S1 between successive rounds of initiation leading to inhibition of translation which eventually results in shutdown of cellular and viral protein synthesis. Also phosphorylates other substrates including p53/TP53, PPP2R5A, DHX9, ILF3, IRS1 and the HHV-1 viral protein US11. In addition to serine/threonine-protein kinase activity, also has tyrosine-protein kinase activity and phosphorylates CDK1 at Tyr-4 upon DNA damage, facilitating its ubiquitination and proteosomal degradation. Either as an adapter protein and/or via its kinase activity, can regulate various signaling pathways (p38 MAP kinase, NF-kappa-B and insulin signaling pathways) and transcription factors (JUN, STAT1, STAT3, IRF1, ATF3) involved in the expression of genes encoding proinflammatory cytokines and IFNs. Activates the NF-kappa-B pathway via interaction with IKBKB and TRAF family of proteins and activates the p38 MAP kinase pathway via interaction with MAP2K6. Can act as both a positive and negative regulator of the insulin signaling pathway (ISP). Negatively regulates ISP by inducing the inhibitory phosphorylation of insulin receptor substrate 1 (IRS1) at Ser-312 and positively regulates ISP via phosphorylation of PPP2R5A which activates FOXO1, which in turn up-regulates the expression of insulin receptor substrate 2 (IRS2). Can regulate NLRP3 inflammasome assembly and the activation of NLRP3, NLRP1, AIM2 and NLRC4 inflammasomes. Can trigger apoptosis via FADD-mediated activation of CASP8. Plays a role in the regulation of the cytoskeleton by binding to gelsolin (GSN), sequestering the protein in an inactive conformation away from actin.
UniProtKB/Swiss-Prot Induction:
By type I interferons.

Enzyme Numbers (IUBMB) for EIF2AK2 Gene

Phenotypes From GWAS Catalog for EIF2AK2 Gene

Gene Ontology (GO) - Molecular Function for EIF2AK2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003723 RNA binding IDA,IEA 22681889
GO:0003725 double-stranded RNA binding TAS,IDA 21266579
GO:0004672 protein kinase activity IMP 21123651
GO:0004674 protein serine/threonine kinase activity TAS 1695551
GO:0004694 eukaryotic translation initiation factor 2alpha kinase activity IMP 25329545
genes like me logo Genes that share ontologies with EIF2AK2: view
genes like me logo Genes that share phenotypes with EIF2AK2: view

Animal Models for EIF2AK2 Gene

MGI Knock Outs for EIF2AK2:

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for EIF2AK2
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for EIF2AK2 Gene

Localization for EIF2AK2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for EIF2AK2 Gene

Cytoplasm. Nucleus. Cytoplasm, perinuclear region. Note=Nuclear localization is elevated in acute leukemia, myelodysplastic syndrome (MDS), melanoma, breast, colon, prostate and lung cancer patient samples or cell lines as well as neurocytes from advanced Creutzfeldt-Jakob disease patients.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for EIF2AK2 gene
Compartment Confidence
nucleus 5
cytosol 5
endoplasmic reticulum 2
cytoskeleton 1
mitochondrion 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for EIF2AK2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005737 cytoplasm IDA,IEA 15121867
GO:0005829 cytosol TAS --
GO:0005840 ribosome TAS 10390359
GO:0016020 membrane IDA 19946888
genes like me logo Genes that share ontologies with EIF2AK2: view

Pathways & Interactions for EIF2AK2 Gene

genes like me logo Genes that share pathways with EIF2AK2: view

SIGNOR curated interactions for EIF2AK2 Gene

Activates:
Inactivates:
Is activated by:

Gene Ontology (GO) - Biological Process for EIF2AK2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000186 activation of MAPKK activity IMP 15229216
GO:0001819 positive regulation of cytokine production ISS --
GO:0002376 immune system process IEA --
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
genes like me logo Genes that share ontologies with EIF2AK2: view

Drugs & Compounds for EIF2AK2 Gene

(27) Drugs for EIF2AK2 Gene - From: DGIdb, HMDB, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Manganese Approved Nutra 35
ATP Nutra Agonist 0
CDK2 INHIBITOR IV Pharma 0
INDIRUBIN DERIVATIVE E804 Pharma 0
PKR INHIBITOR Pharma 0

(17) Additional Compounds for EIF2AK2 Gene - From: Novoseek and HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
ADP
  • Adenosindiphosphorsaeure
  • Adenosine 5'-pyrophosphate
  • Adenosine diphosphate
  • Adenosine pyrophosphate
  • Adenosine-5'-diphosphate
Full agonist, Agonist 58-64-0
genes like me logo Genes that share compounds with EIF2AK2: view

Transcripts for EIF2AK2 Gene

Unigene Clusters for EIF2AK2 Gene

Eukaryotic translation initiation factor 2-alpha kinase 2:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for EIF2AK2
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for EIF2AK2 Gene

No ASD Table

Relevant External Links for EIF2AK2 Gene

GeneLoc Exon Structure for
EIF2AK2
ECgene alternative splicing isoforms for
EIF2AK2

Expression for EIF2AK2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for EIF2AK2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for EIF2AK2 Gene

This gene is overexpressed in Whole Blood (x4.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for EIF2AK2 Gene



Protein tissue co-expression partners for EIF2AK2 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of EIF2AK2 Gene:

EIF2AK2

SOURCE GeneReport for Unigene cluster for EIF2AK2 Gene:

Hs.131431

mRNA Expression by UniProt/SwissProt for EIF2AK2 Gene:

P19525-E2AK2_HUMAN
Tissue specificity: Highly expressed in thymus, spleen and bone marrow compared to non-hematopoietic tissues such as small intestine, liver, or kidney tissues. Colocalizes with GSK3B and TAU in the Alzheimer disease (AD) brain. Elevated levels seen in breast and colon carcinomas,and which correlates with tumor progression and invasiveness or risk of progression.

Evidence on tissue expression from TISSUES for EIF2AK2 Gene

  • Liver(4.3)
  • Nervous system(4.3)
genes like me logo Genes that share expression patterns with EIF2AK2: view

Primer Products

No data available for Protein differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for EIF2AK2 Gene

Orthologs for EIF2AK2 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for EIF2AK2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia EIF2AK2 33 34
  • 99.21 (n)
cow
(Bos Taurus)
Mammalia EIF2AK2 33 34
  • 77.57 (n)
dog
(Canis familiaris)
Mammalia EIF2AK2 33 34
  • 76.95 (n)
rat
(Rattus norvegicus)
Mammalia Eif2ak2 33
  • 73.1 (n)
mouse
(Mus musculus)
Mammalia Eif2ak2 33 16 34
  • 70.83 (n)
oppossum
(Monodelphis domestica)
Mammalia EIF2AK2 34
  • 45 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia EIF2AK2 34
  • 43 (a)
OneToOne
chicken
(Gallus gallus)
Aves EIF2AK2 33 34
  • 53.43 (n)
lizard
(Anolis carolinensis)
Reptilia EIF2AK2 34
  • 39 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia eif2ak2 33
  • 51.87 (n)
zebrafish
(Danio rerio)
Actinopterygii eif2ak2 33 34
  • 49.6 (n)
pkz 34
  • 28 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea gcn-2 34
  • 8 (a)
ManyToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes GCN2 34
  • 7 (a)
OneToMany
IKS1 36
Species where no ortholog for EIF2AK2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for EIF2AK2 Gene

ENSEMBL:
Gene Tree for EIF2AK2 (if available)
TreeFam:
Gene Tree for EIF2AK2 (if available)

Paralogs for EIF2AK2 Gene

Paralogs for EIF2AK2 Gene

(4) SIMAP similar genes for EIF2AK2 Gene using alignment to 7 proteins:

genes like me logo Genes that share paralogs with EIF2AK2: view

Variants for EIF2AK2 Gene

Sequence variations from dbSNP and Humsavar for EIF2AK2 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type
VAR_040475 A lung adenocarcinoma sample
rs1000011081 -- 37,127,120(+) GCCTA(A/G)GTTTC intron-variant
rs1000078528 -- 37,129,711(+) GCCTC(C/T)ATATT intron-variant
rs1000143525 -- 37,143,408(+) TCACA(C/T)GTATA intron-variant
rs1000163044 -- 37,120,210(+) AACTT(C/T)TTAAA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for EIF2AK2 Gene

Variant ID Type Subtype PubMed ID
esv2661177 CNV deletion 23128226
esv2719931 CNV deletion 23290073
esv3555110 CNV deletion 23714750
nsv1072934 CNV deletion 25765185
nsv477575 CNV novel sequence insertion 20440878
nsv511779 CNV loss 21212237

Variation tolerance for EIF2AK2 Gene

Residual Variation Intolerance Score: 7.51% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.30; 6.67% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for EIF2AK2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
EIF2AK2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for EIF2AK2 Gene

Disorders for EIF2AK2 Gene

MalaCards: The human disease database

(15) MalaCards diseases for EIF2AK2 Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
herpes simplex
  • herpesvirus hominis disease
hepatitis c
  • chronic hepatitis c
rift valley fever
vaccinia
measles
  • morbilli
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for EIF2AK2

Genetic Association Database (GAD)
EIF2AK2
Human Genome Epidemiology (HuGE) Navigator
EIF2AK2
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
EIF2AK2
genes like me logo Genes that share disorders with EIF2AK2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for EIF2AK2 Gene

Publications for EIF2AK2 Gene

  1. An antiviral response directed by PKR phosphorylation of the RNA helicase A. (PMID: 19229320) Sadler AJ … Williams BR (PLoS pathogens 2009) 3 4 22 60
  2. PKR activity is required for acute leukemic cell maintenance and growth: a role for PKR-mediated phosphatase activity to regulate GSK-3 phosphorylation. (PMID: 19507191) Blalock WL … Martelli AM (Journal of cellular physiology 2009) 3 4 22 60
  3. Nck-1 interacts with PKR and modulates its activation by dsRNA. (PMID: 18835251) Cardin E … Larose L (Biochemical and biophysical research communications 2008) 3 4 22 60
  4. Interaction of human tRNA-dihydrouridine synthase-2 with interferon-induced protein kinase PKR. (PMID: 18096616) Mittelstadt M … Patel RC (Nucleic acids research 2008) 3 4 22 60
  5. Tyrosine phosphorylation acts as a molecular switch to full-scale activation of the eIF2alpha RNA-dependent protein kinase. (PMID: 16373505) Su Q … Koromilas AE (Proceedings of the National Academy of Sciences of the United States of America 2006) 3 4 22 60

Products for EIF2AK2 Gene

Sources for EIF2AK2 Gene

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