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EIF2AK2 Gene

protein-coding GIFtS: 60

GC02M037246

eukaryotic translation initiation factor 2-alpha kinase 2
(Previous names: protein kinase, interferon-inducible double stranded RNA dependent )
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
(Previous symbol: PRKR)

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
About This Section

Aliases
EC 2.7.11.1 ^³
EIF2AK1 ^¹, ²
MGC126524 ^²
OTTHUMP00000126954 ^²
PKR ^¹, ², ³
PRKR ^², ³

Descriptions
Interferon-inducible RNA-dependent protein kinase ^³
P1/eIF-2A protein kinase ^³
Protein kinase RNA-activated ^³
double stranded RNA activated protein kinase ^²
eIF-2A protein kinase 2 ^³
eukaryotic translation initiation factor 2-alpha kinase 2 ^², ³
interferon-inducible elF2alpha kinase ^²
p68 kinase ^³
protein kinase, interferon-inducible double stranded RNA dependent ^¹, ²

External Ids
HGNC: 9437¹
Entrez Gene: 5610²
UniProtKB: P19525³
Ensembl: ENSG00000055332⁷

Search outside databases for aliases for EIF2AK2 gene

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

UniProtKB/Swiss-Prot: E2AK2_HUMAN, P19525

Function: Following activation by double-stranded RNA in the presence of ATP, the kinase becomes

autophosphorylated and can catalyze the phosphorylation of the translation initiation factor

EIF2S1, which leads to an inhibition of the initiation of protein synthesis. Double-stranded RNA

is generated during the course of a viral infection

Gene Wiki entry for EIF2AK2 (Protein_kinase_R)

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:

UCSC Golden Path with GeneCards custom track

Transcription factor binding sites upstream to the EIF2AK2 gene

Entrez Gene cytogenetic band: 2p22-p21 Ensembl cytogenetic band: 2p22.2 HGNC cytogenetic band: 2p22-p21

EIF2AK2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 2 GeneLoc Exon Structure

GeneLoc location for GC02M037246: (about GC identifiers)

Start:	37,179,857 bp from pter
End:	37,405,184 bp from pter
Size:	225,328 bases
Orientation:	minus strand

RefSeq DNA sequence:

NC_000002.10 NT_022184.14

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
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UniProtKB/Swiss-Prot: E2AK2_HUMAN, P19525 (See protein sequence)

Recommended Name: Interferon-induced, double-stranded RNA-activated protein kinase

Size: 551 amino acids; 62094 Da

Subunit: Homodimer. Interacts with STRBP (By similarity). Interacts with DNAJC3. Inhibited by

direct interaction with viral proteins such as HCV E2, HCV NS5A and influenza A NS1. Activated by

the interaction with HIV-1 Tat

PDB structures from and Proteopedia :

1QU6 (3D)

2A19 (3D)

2A1A (3D)

Secondary accessions: Q52M43 Q9UIR4

Post-translational modifications:

Autophosphorylated on several Ser and Thr residues. Autophosphorylation of Thr-451 is dependent on

Thr-446 and is stimulated by dsRNA binding and dimerization. Autophosphorylation apparently leads

to the activation of the kinase¹

View phosphorylation sites using PhosphoSite²

REFSEQ proteins (3 alternative transcripts):

NP_001129123.1 NP_001129124.1 NP_002750.1

ENSEMBL proteins:

ENSP00000368453 ENSP00000378559 ENSP00000374663 ENSP00000385014 ENSP00000341954 ENSP00000233057

Human Recombinant Proteins

	Invitrogen human recombinant proteins for EIF2AK2
	Millipore Purified and/or Recombinant EIF2AK2 Protein
	Sigma-Aldrich Proteins for EIF2AK2
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Recombinant Proteins from Abcam (PKR)
	Human Recombinant Proteins from Abnova (EIF2AK2)

Browse Origene for full length recombinant human proteins expressed in human HEK293 cells

1 Gene Ontology (GO) cellular component term (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005622	intracellular	IEA	--

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Antibodies for EIF2AK2:

	Browse Antibodies Central at Invitrogen
	Millipore Mono- and Polyclonal Antibodies for the study of EIF2AK2
	Sigma-Aldrich Antibody Arrays and Antibodies for EIF2AK2
	Browse R&D Systems for Antibodies
	Cell Signaling Technology (CST) Antibodies for EIF2AK2 (PKR)
	Antibodies from Abcam (PKR), each with their Abpromise^SM
	Monoclonal and Polyclonal Antibodies from Abnova (EIF2AK2)
	Novus Biologicals Antibodies for EIF2AK2

Assays for EIF2AK2:

	Invitrogen Assays for EIF2AK2
	Browse Kits and Assays available from Millipore
	Browse R&D Systems for biochemical assays
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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Graphical View of Domain Structure for InterPro Entry P19525

ProtoNet protein and cluster: P19525

1 Blocks protein family: IPB001159 Double-stranded RNA binding (DsRBD) domain

UniProtKB/Swiss-Prot: E2AK2_HUMAN, P19525

Similarity: Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. GCN2

subfamily

Similarity: Contains 2 DRBM (double-stranded RNA-binding) domains

Similarity: Contains 1 protein kinase domain

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (EIF2AK2)
		Millipore RNAi Products for the Analysis of EIF2AK2 Gene knock-down
		Abnova Chimera RNAi Products for Gene knock-down (EIF2AK2)

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 3): NM_002759

Applied Biosystems Silencer® siRNAs for EIF2AK2

Sigma-Aldrich siRNA and siRNA Panels for EIF2AK2

Sigma-Aldrich shRNA Panels and shRNA for EIF2AK2

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Invitrogen Clones for EIF2AK2
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clones in CMV expression vector (see all 3): NM_001135651
Myc/DDK tagged cDNA clones in CMV expression vector (see all 3): NM_001135651
untagged cDNA clones in CMV expression vector (see all 5): NM_001135651

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_001135651

UniProtKB/Swiss-Prot: E2AK2_HUMAN, P19525

Function: Following activation by double-stranded RNA in the presence of ATP, the kinase becomes

autophosphorylated and can catalyze the phosphorylation of the translation initiation factor

EIF2S1, which leads to an inhibition of the initiation of protein synthesis. Double-stranded RNA

is generated during the course of a viral infection

Catalytic activity: ATP + a protein = ADP + a phosphoprotein

Enzyme regulation: Activity is markedly stimulated by manganese ions. Besides dsRNA, heparin is a

potent activator of the kinase. Binding to dsRNA is required for dimerization leading to

autophosphorylation in the activation loop and stimulation of function. Inhibited by vaccinia

virus protein E3, probably via dsRNA sequestering

Induction: By interferon

Enzyme Number (IUBMB): EC 2.7.11.1

2 MGI mutant phenotypes (inferred from 2 alleles) (MGI details for Eif2ak2):

hematopoietic system

immune system

5/7 Gene Ontology (GO) molecular function terms (links to tree view) (see all 7 ):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0000166	nucleotide binding	IEA	--
GO:0003725	double-stranded RNA binding	TAS	1351683
GO:0004694	eukaryotic translation initiation factor 2alpha kinase activity	TAS	10866685
GO:0005515	protein binding	IPI	8576172 16288713 17353931
GO:0005524	ATP binding	IEA	--

About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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5/8 Sigma-Aldrich "Your Favorite Gene" Pathways for EIF2AK2 (Your Favorite Gene powered by Ingenuity) (see all 8 )

NF-&kappa
Inositol Phosphate Metabolism
NF-&kappa
Nicotinate and Nicotinamide Metabolism
PDGF Signaling

GeneDecks EIF2AK2 for the pathways selected above

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Gene Network Central^TM Interacting Genes and Proteins Network for EIF2AK2

5/10 Interacting proteins for EIF2AK2 (P19525^{1, 2} ENSP00000374663³) via UniProtKB, MINT, and/or STRING (see all 10 )

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
EIF2S1	P05198¹^,²	EBI-640775, EBI-1056162 MINT-6740625 MINT-6740637 MINT-6740644 EBI-640775, EBI-1056162 MINT-6740625 MINT-6740637 MINT-6740644
DBNL	Q9UJU6¹	EBI-640775, EBI-751783
DNAJC3 DNAJC3 (xeno)	Q27968¹	EBI-640775, EBI-640793
EIF2S1	P05198¹^,²	EBI-640775, EBI-1056162 MINT-6740625 MINT-6740637 MINT-6740644 EBI-640775, EBI-1056162 MINT-6740625 MINT-6740637 MINT-6740644
NPM1	P06748²	MINT-3089429 MINT-3089371 MINT-3089394

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5/7 Gene Ontology (GO) biological process terms (links to tree view) (see all 7 ):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006412	translation	IEA	--
GO:0006926	virus-infected cell apoptosis	IEA	--
GO:0008285	negative regulation of cell proliferation	TAS	1351683
GO:0009615	response to virus	IEA	--
GO:0030968	endoplasmic reticulum unfolded protein response	IEA	--

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(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse drugs & compounds from Enzo Life Sciences

Browse Small Molecules at Sigma-Aldrich

Browse Tocris compounds for EIF2AK2
10/17 Novoseek chemical compound relationships for EIF2AK2 gene (see all 17 )

Compound	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
nf 45	62.28	3	11438540 (2)
threonine	60.87	38	15737233 (2), 16613840 (2), 7686884 (1), 9034343 (1) (see all 33)
poly(i-c)	51.68	9	9765401 (2), 7901291 (1), 15607693 (1), 17341633 (1)
ifn-alpha	47.90	8	8929499 (2), 18535617 (2), 15290347 (1), 17764414 (1)
poly c	31.70	2	2219731 (1), 10648614 (1)
inosine monophosphate	29.61	2	15229216 (1), 10648614 (1)
iptg	23.41	1	1718419 (1)
rantes	16.93	3	17600282 (2), 16699048 (1)
nucleoside	7.87	2	18426922 (2)
nitric oxide	3.64	8	18559534 (2), 11272138 (2)

About this table

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (EIF2AK2)
		Millipore RNAi Products for the Analysis of EIF2AK2 Gene knock-down
		Abnova Chimera RNAi Products for Gene knock-down (EIF2AK2)

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 3): NM_002759

Sigma-Aldrich siRNA and siRNA Panels for EIF2AK2

Sigma-Aldrich shRNA Panels and shRNA for EIF2AK2

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_001135651 NM_001135652 NM_002759

REFSEQ mRNAs for EIF2AK2 gene (3 alternative transcripts):

NM_001135651.1 NM_001135652.1 NM_002759.2

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_001135651 NM_001135652 NM_002759

               OriGene GFP tagged cDNA clones in CMV expression vector (see all 3): NM_001135651
                                 Myc/DDK tagged cDNA clones in CMV expression vector (see all 3): NM_001135651
                                 untagged cDNA clones in CMV expression vector (see all 5): NM_001135651

Additional cDNA sequence:

AF086566.1 AK290655.1 AK313818.1 AY302136.1 BC007769.2 BC022314.1 BC040851.1 BC057805.1

BC093676.1 BC101475.1 BC143228.1 BC143230.1 CR600308.1 M35663.1 M85294.1

12 DOTS entries:

DT.412798 DT.100790892 DT.92054033 DT.95298593 DT.40202404 DT.97835949 DT.92458447 DT.92458452

DT.95277628 DT.121014262 DT.100790891 DT.95277625

24/265 AceView cDNA sequences (see all 265 ):

BU615395 AA295844 AI472475 AA393792 CA448019 CA448115 AU119328 AW167249

N62286 BC022314 BQ428392 AA477717 BU618209 AW615284 CA445747 AI360504

AA700984 AI873824 CR600308 AL600941 BQ002126 AI369437 AI348332 BX362627

highest scoring ESTs for EIF2AK2:

BC040851 BC057805 AA010079 AA488335 AA730488 AF086566 AI074902 AI360504 AI687893 AI816883

Unigene Cluster for EIF2AK2:

Eukaryotic translation initiation factor 2-alpha kinase 2

Hs.131431 [show with all ESTs]

Unigene Representative Sequence: NM_002759

GeneLoc Exon Structure

6 Ensembl transcripts including schematic representations:

ENST00000379156 ENST00000395127 ENST00000390013 ENST00000405334 ENST00000343510 ENST00000233057

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
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EIF2AK2 expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for EIF2AK2

¹ / ² / ³

12 probe-sets matching EIF2AK2 gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
38662_at²^{, 3}	U95-A	1	1.00	1.00	0.67	1.07	AL047596	0.20	0.50	0.38	1
85147_at²^{, 3}	U95-D	1	1.00	1.00	0.53	0.61	AI494047	0.20	1.00	0.72	1
61940_at²^{, 3}	U95-C	1	1.00	1.00	-0.12	0.25	W28128	0.20	1.00	0.72	1
1008_f_at²^{, 3}	U95-A	3099	1.00	0.41	0.12	1.59	U50648	0.20	1.00	0.72	1
80047_at²^{, 3}	U95-E	1	0.81	1.00	0.90	0.68	AI805760	0.40	1.00	0.76	1
73536_f_at²^{, 3}	U95-D	1497	0.31	0.01	0.14	1.85	AA737775	0.20	0.33	0.27	1
238743_at²	U133-B	1	1.00	1.00	--	--	--	--	--	--	--
213294_at²	U133-A	1	1.00	1.00	--	--	--	--	--	--	--
204211_x_at²^{, 3}	U133-A	6	1.00	0.87	--	--	NM_002759	0.60	1.00	0.82	1
242898_at²^{, 3}	U133-B	1	0.91	1.00	--	--	AI494047	0.20	1.00	0.72	1
213294_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
204211_x_at²	U133Plus2	6	1.00	0.87	--	--	--	--	--	--	--

GeneDecks EIF2AK2 for binary patterns associated with the probe-sets selected above

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Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: --

SOURCE GeneReport for Unigene cluster: Hs.131431
Expression variation in blood from EXPOLDB for EIF2AK2

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for EIF2AK2 gene from 5/8 species (see all 8 )

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	EIF2AK2¹	--	eukaryotic translation initiation factor 2-alpha kinase more	76.61(n) 66.74(a)	611397 XM_849059.1 XP_854152.1
chimpanzee (Pan troglodytes)	EIF2AK2¹	--	eukaryotic translation initiation factor 2-alpha kinase more	98.91(n) 98.55(a)	459155 XM_001166436.1 XP_001166436.1
cow (Bos taurus)	EIF2AK2¹	--	eukaryotic translation initiation factor 2-alpha kinase more	77(n) 64.84(a)	347700 NM_178109.1 NP_835210.1
rat (Rattus norvegicus)	Eif2ak2¹	--	eukaryotic translation initiation factor 2-alpha kinase more	72.78(n) 62.86(a)	54287 XM_579433.2 XP_579433.2
mouse (Mus musculus)	Eif2ak2^{1, 5}	17 (40.00 cM)⁵	eukaryotic translation initiation factor 2-alpha kinase more^{1, 5}	71.09(n)¹ 62.38(a)¹	19106¹ NM_011163.3¹ NP_035293.1¹ AI467567⁵ AI747578⁵ (see all 31)

About this table Species with no ortholog for EIF2AK2

ENSEMBL Gene Tree for EIF2AK2

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

Paralogs for EIF2AK2 gene

EIF2AK1² EIF2AK4² EIF2AK3²

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

10/360 NCBI SNPs in EIF2AK2 are shown (see all 360 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 90)

AB	SNP ID	Valid	Chr 2 pos	Sequence	Recs	AA Chg	Type	More	Recs	Allele freq	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--				--
	rs2254958^1,2	A,C,F,H	37229795(-)	`GGCATC/TGAGGT`	1	--	ut5¹ ese³		28		NA EA NS MN EU WA CSAM	2542
	rs2307472^1,2	C,F,H	37229751(-)	`CATAGA/GCCTTA`	1	--	ut5¹ ese³		16		NA NS MN CSAM EA EU WA	1272
	rs2307466^1,2	C,F,H	37229818(-)	`ACATCC/GTAAAC`	1	--	ut5¹		22		NA NS MN CSAM EA EU WA	1940
--	rs2307468^1,2	C,F	37229781(-)	`TCCCAA/CTAAAA`	1	--	ut5¹		7		NA NS MN CSAM EA	746
	rs4648246^1,2	F,H	37186883(-)	`aattcC/Gattta`	1	--	ng5¹		5		NS EU EA WA	596
--	rs12619587^1,2	A,C	37239405(+)	`GGGTAA/GAGTGT`	1	--	ng3¹		0	--	--	--	--
	rs11892108^1,2	A,C	37238955(+)	`CCTTGC/TAGCTC`	1	--	ng3¹		0	--	--	--	--
--	rs13018861^1,2	A	37237832(+)	`GACCCC/TGCACC`	1	--	ng3¹		0	--	--	--	--
--	rs11892180^1,2	A	37239160(+)	`TTTTCC/TGACTT`	1	--	ng3¹		0	--	--	--	--
--	rs12473749^1,2	C	37239497(+)	`ATTACA/CATATA`	1	--	ng3¹		0	--	--	--	--

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HapMap Linkage Disequilibrium images for EIF2AK2 (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
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OMIM: 176871

10/52 Novoseek disease relationships for EIF2AK2 gene (see all 52 )

Disease	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
virus infection	68.04	77	11232238 (2), 10878375 (2), 11752660 (2), 10712589 (2) (see all 53)
vesicular stomatitis	56.61	8	8974011 (2), 15070037 (2), 15174900 (1), 11838900 (1)
hepatitis c	56.03	27	14638359 (1), 15850464 (1), 10745229 (1), 10827164 (1) (see all 24)
influenza	46.18	29	17320139 (4), 8990167 (2), 8892939 (2), 10954584 (2) (see all 14)
herpes simplex	41.25	13	16414988 (2), 9765401 (2), 9223497 (2), 9023344 (1) (see all 10)
hepatitis c chronic	35.89	6	15535414 (2), 12210408 (1), 17501760 (1), 15684819 (1)
immunodeficiency	33.37	12	9079663 (2), 2180064 (1), 10400814 (1), 15737233 (1) (see all 10)
fanconis anemia	29.50	4	12882984 (2), 11238103 (1), 15299030 (1)
mumps	26.57	4	18567898 (3), 9856085 (1)
chronic fatigue syndrome	23.30	2	11698994 (1), 9243369 (1)

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Genetic Association Database: EIF2AK2
Human Genome Epidemiology Navigator: EIF2AK2 (5 documents)

(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
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10/535 PubMed articles for EIF2AK2 gene (see all 535 ):

The Tat protein of human immunodeficiency virus type 1 is a substrate and inhibitor of the interferon-induced, virally activated protein kinase, PKR. (PubMed id 9079663)^{1, 3, 4} Brand S.R.... Mathews M.B. (1997)
The P58 cellular inhibitor complexes with the interferon-induced, double-stranded RNA-dependent protein kinase, PKR, to regulate its autophosphorylation and activity. (PubMed id 8576172)^{1, 3, 4} Polyak S.J.... Katze M.G. (1996)
Genomic features of human PKR: alternative splicing and a polymorphic CGG repeat in the 5'-untranslated region. (PubMed id 9726442)^{1, 3, 4} Xu Z. and Williams B.R. (1998)
Structural organization of the human gene (PKR) encoding an interferon-inducible RNA-dependent protein kinase (PKR) and differences from its mouse homolog. (PubMed id 8812437)^{1, 3, 4} Kuhen K.L.... Samuel C.E. (1996)
Polymorphisms in interferon-induced genes and the outcome of hepatitis C virus infection: roles of MxA, OAS-1 and PKR. (PubMed id 12944978)^{1, 3, 6} Knapp S....Thursz M.R. (2003)
Molecular cloning and characterization of the human double-stranded RNA-activated protein kinase induced by interferon. (PubMed id 1695551)^{1, 3, 4} Meurs E.... Hovanessian A.G. (1990)
Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PubMed id 15815621)^{3, 4} Hillier L.W....Wilson R.K. (2005)
Inhibition of PKR by vaccinia virus: role of the N- and C-terminal domains of E3L. (PubMed id 15207627)^{3, 4} Langland J.O. and Jacobs B.L. (2004)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{3, 4} Gerhard D.S....Malek J. (2004)
Genetic polymorphisms in interferon pathway and response to interferon treatment in hepatitis B patients: A pilot study. (PubMed id 12447867)^{3, 6} King J.K....Chen P.J. (2002)

(in PubMed, OMIM, and NCBI Bookshelf)
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Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
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Entrez Gene: 5610	HGNC: 9437	AceView: PRKR	Ensembl:ENSG00000055332	euGenes: HUgn5610
ECgene: EIF2AK2	H-InvDB: EIF2AK2

(According to HUGE)
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(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
ATLAS Chromosomes in Cancer entry for EIF2AK2	Genetics and Cytogenetics in Oncology and Haematology
NIEHS-SNPs	http://egp.gs.washington.edu/data/prkr/

Licensable Technologies for EIF2AK2
(Available from WIS Yeda, Salk, Tufts)

About This Section

(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
About This Section

Products for EIF2AK2:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for EIF2AK2-related products

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

	Predesigned and custom siRNAs for EIF2AK2		Antibodies for EIF2AK2
	Explore super-pooled esiRNAs		Proteins for EIF2AK2
	Lentivirus-delivered shRNAs for EIF2AK2		Browse small molecules at Sigma-Aldrich
	"Your Favorite Gene" Pathways		feedback

	Antibodies		Primer Pairs
	Cell Culture Products		ELISAs
	Flow Cytometry Kits		Protease Activity Assays & Reagents
	Cell Selection/Detection Kits & Reagents		ELISA/Assay Development Kits & Reagents
	Multiplex/Array Assay Kits & Reagents		ELISpot Kits & Development Modules
	Recombinant & Natural Proteins

	Recombinant Proteins (EIF2AK2)
	Antibodies (EIF2AK2)
	Chimera RNAi (EIF2AK2)
	Custom Service for Mouse Mab
	Custom Service for Rabbit Pab from Full-length Protein

Antibodies & Assays for EIF2AK2 (PKR)

	Recombinant Proteins (PKR)
	Antibodies (PKR)

Search OriGene for EIF2AK2

Search Tocris compounds for EIF2AK2

Search www.enzolifesicences.com for proteins, assays, substrates, inhibitors & antibodies

Antibodies for EIF2AK2

GeneCards Homepage - Last full update: 2 Jul 2009 Incremental update: 13 Oct 2009

Random Gene From GIFtS :

about GIFtS

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Developed at the Crown Human Genome Center & Weizmann Institute of Science

The GeneCards Human Gene Database: Copyright © 1996-2009, Weizmann Institute of Science. All Rights Reserved.
EIF2AK2 Gene at Home site.
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EIF2AK2 Gene

protein-coding GIFtS: 60

Aliases &
Descriptions
for EIF2AK2

Summaries
for EIF2AK2

Genomic Location
for EIF2AK2

Proteins
for EIF2AK2

Protein Domains/
Families
for EIF2AK2

Gene Function
for EIF2AK2

Pathways & Interactions
for EIF2AK2

Drugs & Compounds
for EIF2AK2

Transcripts
for EIF2AK2

Expression
for EIF2AK2

Orthologs
for EIF2AK2

Paralogs
for EIF2AK2

SNPs/Variants
for EIF2AK2

Disorders & Mutations
for EIF2AK2

Medical News
for EIF2AK2

Publications
for EIF2AK2

Search for EIF2AK2

Genome Databases showing EIF2AK2

Other Databases showing EIF2AK2

Specialized Databases showing EIF2AK2

Licensable Technologies
for EIF2AK2

Services
for EIF2AK2

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

EIF2AK2 Gene

protein-coding GIFtS: 60

Aliases & Descriptionsfor EIF2AK2

Summariesfor EIF2AK2

Genomic Locationfor EIF2AK2

Proteinsfor EIF2AK2

Protein Domains/Familiesfor EIF2AK2

Gene Functionfor EIF2AK2

Pathways & Interactionsfor EIF2AK2

Drugs & Compoundsfor EIF2AK2

Transcriptsfor EIF2AK2

Expression for EIF2AK2

Orthologsfor EIF2AK2

Paralogsfor EIF2AK2

SNPs/Variantsfor EIF2AK2

Disorders & Mutationsfor EIF2AK2

Medical Newsfor EIF2AK2

Publicationsfor EIF2AK2

Search for EIF2AK2

Genome Databases showing EIF2AK2

Other Databases showing EIF2AK2

Specialized Databases showing EIF2AK2

Licensable Technologiesfor EIF2AK2

Servicesfor EIF2AK2

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for EIF2AK2

Summaries
for EIF2AK2

Genomic Location
for EIF2AK2

Proteins
for EIF2AK2

Protein Domains/
Families
for EIF2AK2

Gene Function
for EIF2AK2

Pathways & Interactions
for EIF2AK2

Drugs & Compounds
for EIF2AK2

Transcripts
for EIF2AK2

Expression
for EIF2AK2

Orthologs
for EIF2AK2

Paralogs
for EIF2AK2

SNPs/Variants
for EIF2AK2

Disorders & Mutations
for EIF2AK2

Medical News
for EIF2AK2

Publications
for EIF2AK2

Licensable Technologies
for EIF2AK2

Services
for EIF2AK2