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Aliases for EIF2AK2 Gene

Aliases for EIF2AK2 Gene

  • Eukaryotic Translation Initiation Factor 2-Alpha Kinase 2 2 3 4
  • Protein Kinase, Interferon-Inducible Double Stranded RNA Dependent 2 3
  • Tyrosine-Protein Kinase EIF2AK2 3 4
  • P1/EIF-2A Protein Kinase 3 4
  • EIF-2A Protein Kinase 2 3 4
  • Protein Kinase R 3 4
  • P68 Kinase 3 4
  • PRKR 3 4
  • PKR 3 4
  • Interferon-Inducible RNA-Dependent Protein Kinase 4
  • Double Stranded RNA Activated Protein Kinase 3
  • Protein Phosphatase 1, Regulatory Subunit 83 3
  • Interferon-Inducible ElF2alpha Kinase 3
  • Protein Kinase RNA-Activated 4
  • Protein Phosphatase 1 2
  • Regulatory Subunit 83 2
  • EC 2.7.11.1 4
  • EC 2.7.10.2 4
  • EIF2AK1 3
  • PPP1R83 3

External Ids for EIF2AK2 Gene

Previous HGNC Symbols for EIF2AK2 Gene

  • PRKR

Previous GeneCards Identifiers for EIF2AK2 Gene

  • GC02M037246
  • GC02M037326

Summaries for EIF2AK2 Gene

Entrez Gene Summary for EIF2AK2 Gene

  • The protein encoded by this gene is a serine/threonine protein kinase that is activated by autophosphorylation after binding to dsRNA. The activated form of the encoded protein can phosphorylate translation initiation factor EIF2S1, which in turn inhibits protein synthesis. This protein is also activated by manganese ions and heparin. Three transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Oct 2011]

GeneCards Summary for EIF2AK2 Gene

EIF2AK2 (Eukaryotic Translation Initiation Factor 2-Alpha Kinase 2) is a Protein Coding gene. Diseases associated with EIF2AK2 include fanconi anemia, complementation group c and rift valley fever. Among its related pathways are Immune System and Infectious disease. GO annotations related to this gene include poly(A) RNA binding and protein kinase activity. An important paralog of this gene is EIF2AK4.

UniProtKB/Swiss-Prot for EIF2AK2 Gene

  • IFN-induced dsRNA-dependent serine/threonine-protein kinase which plays a key role in the innate immune response to viral infection and is also involved in the regulation of signal transduction, apoptosis, cell proliferation and differentiation. Exerts its antiviral activity on a wide range of DNA and RNA viruses including hepatitis C virus (HCV), hepatitis B virus (HBV), measles virus (MV) and herpes simplex virus 1 (HHV-1). Inhibits viral replication via phosphorylation of the alpha subunit of eukaryotic initiation factor 2 (EIF2S1), this phosphorylation impairs the recycling of EIF2S1 between successive rounds of initiation leading to inhibition of translation which eventually results in shutdown of cellular and viral protein synthesis. Also phosphorylates other substrates including p53/TP53, PPP2R5A, DHX9, ILF3, IRS1 and the HHV-1 viral protein US11. In addition to serine/threonine-protein kinase activity, also has tyrosine-protein kinase activity and phosphorylates CDK1 at Tyr-4 upon DNA damage, facilitating its ubiquitination and proteosomal degradation. Either as an adapter protein and/or via its kinase activity, can regulate various signaling pathways (p38 MAP kinase, NF-kappa-B and insulin signaling pathways) and transcription factors (JUN, STAT1, STAT3, IRF1, ATF3) involved in the expression of genes encoding proinflammatory cytokines and IFNs. Activates the NF-kappa-B pathway via interaction with IKBKB and TRAF family of proteins and activates the p38 MAP kinase pathway via interaction with MAP2K6. Can act as both a positive and negative regulator of the insulin signaling pathway (ISP). Negatively regulates ISP by inducing the inhibitory phosphorylation of insulin receptor substrate 1 (IRS1) at Ser-312 and positively regulates ISP via phosphorylation of PPP2R5A which activates FOXO1, which in turn up-regulates the expression of insulin receptor substrate 2 (IRS2). Can regulate NLRP3 inflammasome assembly and the activation of NLRP3, NLRP1, AIM2 and NLRC4 inflammasomes. Can trigger apoptosis via FADD-mediated activation of CASP8. Plays a role in the regulation of the cytoskeleton by binding to gelsolin (GSN), sequestering the protein in an inactive conformation away from actin.

Gene Wiki entry for EIF2AK2 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for EIF2AK2 Gene

Genomics for EIF2AK2 Gene

Regulatory Elements for EIF2AK2 Gene

Transcription factor binding sites by QIAGEN in the EIF2AK2 gene promoter:

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for EIF2AK2 Gene

Chromosome:
2
Start:
37,099,210 bp from pter
End:
37,157,065 bp from pter
Size:
57,856 bases
Orientation:
Minus strand

Genomic View for EIF2AK2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for EIF2AK2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for EIF2AK2 Gene

Proteins for EIF2AK2 Gene

  • Protein details for EIF2AK2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P19525-E2AK2_HUMAN
    Recommended name:
    Interferon-induced, double-stranded RNA-activated protein kinase
    Protein Accession:
    P19525
    Secondary Accessions:
    • A8K3P0
    • D6W584
    • E9PC80
    • Q52M43
    • Q7Z6F6
    • Q9UIR4

    Protein attributes for EIF2AK2 Gene

    Size:
    551 amino acids
    Molecular mass:
    62094 Da
    Quaternary structure:
    • Homodimer. Interacts with STRBP (By similarity). Interacts with DNAJC3. Inhibited by direct interaction with viral proteins such as HCV E2, HCV NS5A and influenza A NS1. Activated by the interaction with HIV-1 Tat (By similarity). Forms a complex with FANCA, FANCC, FANCG and HSP70. Interacts with ADAR/ADAR1. Interacts with IRS1 (By similarity). The inactive form interacts with NCK1 and GSN. Interacts (via the kinase catalytic domain) with STAT3 (via SH2 domain), TRAF2 (C-terminus), TRAF5 (C-terminus) and TRAF6 (C-terminus). Interacts with MAP2K6, IKBKB/IKKB, NPM1, TARBP2, NLRP1, NLRP3, NLRC4 and AIM2. Interacts (via DRBM 1 domain) with DUS2L (via DRBM domain). Interacts with DHX9 (via N-terminus) and this interaction is dependent upon activation of the kinase. Interacts with human herpes simplex virus 1 (HHV-1) protein US11 in an RNA-dependent manner. The inactive form interacts with Toscana virus (TOS) NSS. Interacts with herpes virus 8 protein v-IRF2; this interaction inhibits EIF2AK2 activation.

    Three dimensional structures from OCA and Proteopedia for EIF2AK2 Gene

    Alternative splice isoforms for EIF2AK2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for EIF2AK2 Gene

Proteomics data for EIF2AK2 Gene at MOPED

Post-translational modifications for EIF2AK2 Gene

  • Autophosphorylated on several Ser, Thr and Tyr residues. Autophosphorylation of Thr-451 is dependent on Thr-446 and is stimulated by dsRNA binding and dimerization. Autophosphorylation apparently leads to the activation of the kinase. Tyrosine autophosphorylation is essential for efficient dsRNA-binding, dimerization, and kinase activation.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for EIF2AK2 Gene

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for EIF2AK2 (PKR)

No data available for DME Specific Peptides for EIF2AK2 Gene

Domains & Families for EIF2AK2 Gene

Suggested Antigen Peptide Sequences for EIF2AK2 Gene

Graphical View of Domain Structure for InterPro Entry

P19525

UniProtKB/Swiss-Prot:

E2AK2_HUMAN :
  • Contains 2 DRBM (double-stranded RNA-binding) domains.
  • Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. GCN2 subfamily.
Domain:
  • Contains 2 DRBM (double-stranded RNA-binding) domains.
  • Contains 1 protein kinase domain.
Family:
  • Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. GCN2 subfamily.
genes like me logo Genes that share domains with EIF2AK2: view

Function for EIF2AK2 Gene

Molecular function for EIF2AK2 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
ATP + a protein = ADP + a phosphoprotein
UniProtKB/Swiss-Prot CatalyticActivity:
ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.
UniProtKB/Swiss-Prot EnzymeRegulation:
Initially produced in an inactive form and is activated by binding to viral dsRNA, which causes dimerization and autophosphorylation in the activation loop and stimulation of function. ISGylation can activate it in the absence of viral infection. Can also be activated by heparin, proinflammatory stimuli, growth factors, cytokines, oxidative stress and the cellular protein PRKRA. Activity is markedly stimulated by manganese ions. Activation is blocked by the viral components HIV-1 Tat protein and large amounts of HIV-1 trans-activation response (TAR) RNA element as well as by the cellular proteins TARBP2, DUS2L, NPM1, NCK1 and ADAR. Down-regulated by Toscana virus (TOS) and Rift valley fever virus (RVFV) NSS which promote its proteasomal degradation. Inhibited by vaccinia virus protein E3, probably via dsRNA sequestering.
UniProtKB/Swiss-Prot Function:
IFN-induced dsRNA-dependent serine/threonine-protein kinase which plays a key role in the innate immune response to viral infection and is also involved in the regulation of signal transduction, apoptosis, cell proliferation and differentiation. Exerts its antiviral activity on a wide range of DNA and RNA viruses including hepatitis C virus (HCV), hepatitis B virus (HBV), measles virus (MV) and herpes simplex virus 1 (HHV-1). Inhibits viral replication via phosphorylation of the alpha subunit of eukaryotic initiation factor 2 (EIF2S1), this phosphorylation impairs the recycling of EIF2S1 between successive rounds of initiation leading to inhibition of translation which eventually results in shutdown of cellular and viral protein synthesis. Also phosphorylates other substrates including p53/TP53, PPP2R5A, DHX9, ILF3, IRS1 and the HHV-1 viral protein US11. In addition to serine/threonine-protein kinase activity, also has tyrosine-protein kinase activity and phosphorylates CDK1 at Tyr-4 upon DNA damage, facilitating its ubiquitination and proteosomal degradation. Either as an adapter protein and/or via its kinase activity, can regulate various signaling pathways (p38 MAP kinase, NF-kappa-B and insulin signaling pathways) and transcription factors (JUN, STAT1, STAT3, IRF1, ATF3) involved in the expression of genes encoding proinflammatory cytokines and IFNs. Activates the NF-kappa-B pathway via interaction with IKBKB and TRAF family of proteins and activates the p38 MAP kinase pathway via interaction with MAP2K6. Can act as both a positive and negative regulator of the insulin signaling pathway (ISP). Negatively regulates ISP by inducing the inhibitory phosphorylation of insulin receptor substrate 1 (IRS1) at Ser-312 and positively regulates ISP via phosphorylation of PPP2R5A which activates FOXO1, which in turn up-regulates the expression of insulin receptor substrate 2 (IRS2). Can regulate NLRP3 inflammasome assembly and the activation of NLRP3, NLRP1, AIM2 and NLRC4 inflammasomes. Can trigger apoptosis via FADD-mediated activation of CASP8. Plays a role in the regulation of the cytoskeleton by binding to gelsolin (GSN), sequestering the protein in an inactive conformation away from actin.
UniProtKB/Swiss-Prot Induction:
By type I interferons.

Enzyme Numbers (IUBMB) for EIF2AK2 Gene

Gene Ontology (GO) - Molecular Function for EIF2AK2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003725 double-stranded RNA binding IDA 21266579
GO:0004672 protein kinase activity IMP 21123651
GO:0004674 protein serine/threonine kinase activity TAS 1695551
GO:0004694 eukaryotic translation initiation factor 2alpha kinase activity TAS 10866685
GO:0004715 non-membrane spanning protein tyrosine kinase activity IEA --
genes like me logo Genes that share ontologies with EIF2AK2: view
genes like me logo Genes that share phenotypes with EIF2AK2: view

Animal Models for EIF2AK2 Gene

MGI Knock Outs for EIF2AK2:

Animal Model Products

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for EIF2AK2

In Situ Assay Products

Flow Cytometry Products

No data available for Transcription Factor Targets and HOMER Transcription for EIF2AK2 Gene

Localization for EIF2AK2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for EIF2AK2 Gene

Cytoplasm. Nucleus. Cytoplasm, perinuclear region. Note=Nuclear localization is elevated in acute leukemia, myelodysplastic syndrome (MDS), melanoma, breast, colon, prostate and lung cancer patient samples or cell lines as well as neurocytes from advanced Creutzfeldt-Jakob disease patients.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for EIF2AK2 Gene COMPARTMENTS Subcellular localization image for EIF2AK2 gene
Compartment Confidence
nucleus 5
cytosol 4
endoplasmic reticulum 2

Gene Ontology (GO) - Cellular Components for EIF2AK2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005737 cytoplasm IDA 15121867
GO:0005829 cytosol TAS --
GO:0005840 ribosome TAS 10390359
GO:0016020 membrane IDA 19946888
genes like me logo Genes that share ontologies with EIF2AK2: view

Pathways & Interactions for EIF2AK2 Gene

genes like me logo Genes that share pathways with EIF2AK2: view

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays

SIGNOR curated interactions for EIF2AK2 Gene

Activates:
Inactivates:
Is activated by:

Gene Ontology (GO) - Biological Process for EIF2AK2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000186 activation of MAPKK activity IMP 15229216
GO:0001819 positive regulation of cytokine production ISS --
GO:0006351 transcription, DNA-templated IEA --
GO:0006412 translation IEA --
GO:0006468 protein phosphorylation IDA 19189853
genes like me logo Genes that share ontologies with EIF2AK2: view

Drugs & Compounds for EIF2AK2 Gene

(24) Drugs for EIF2AK2 Gene - From: NovoSeek, HMDB, and DGIdb

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Adenosine triphosphate Approved Nutra 0
Chloramphenicol Approved Pharma 6
chloroquine Approved Pharma Agonist 137
Gefitinib Approved, Investigational Pharma EGFR Inhibitors, Kinase Inhibitors, Epidermal growth factor receptor (EGFR) inhibitors 322
Heparin Approved, Investigational Pharma Antagonist 672,226

(21) Additional Compounds for EIF2AK2 Gene - From: HMDB and NovoSeek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
ADP
  • Adenosindiphosphorsaeure
  • Adenosine 5'-pyrophosphate
  • Adenosine diphosphate
  • Adenosine pyrophosphate
  • Adenosine-5'-diphosphate
Antagonist, Gating inhibitor 58-64-0
2,5-Oligoadenylate
arsenite
  • AArsenite (AsO33-)
  • Arsenic (III) oxide
  • Arsenic (III) trioxide
  • Arsenic sesquioxide
  • Arsenic trioxide
15502-74-6
aspartate
Ceramide
3102-57-6
genes like me logo Genes that share compounds with EIF2AK2: view

Transcripts for EIF2AK2 Gene

Unigene Clusters for EIF2AK2 Gene

Eukaryotic translation initiation factor 2-alpha kinase 2:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for EIF2AK2

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for EIF2AK2 Gene

No ASD Table

Relevant External Links for EIF2AK2 Gene

GeneLoc Exon Structure for
EIF2AK2
ECgene alternative splicing isoforms for
EIF2AK2

Expression for EIF2AK2 Gene

mRNA expression in normal human tissues for EIF2AK2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for EIF2AK2 Gene

This gene is overexpressed in Whole Blood (x4.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for EIF2AK2 Gene



SOURCE GeneReport for Unigene cluster for EIF2AK2 Gene Hs.131431

mRNA Expression by UniProt/SwissProt for EIF2AK2 Gene

P19525-E2AK2_HUMAN
Tissue specificity: Highly expressed in thymus, spleen and bone marrow compared to non-hematopoietic tissues such as small intestine, liver, or kidney tissues. Colocalizes with GSK3B and TAU in the Alzheimer disease (AD) brain. Elevated levels seen in breast and colon carcinomas,and which correlates with tumor progression and invasiveness or risk of progression.
genes like me logo Genes that share expression patterns with EIF2AK2: view

Protein tissue co-expression partners for EIF2AK2 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for Protein differential expression in normal tissues for EIF2AK2 Gene

Orthologs for EIF2AK2 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for EIF2AK2 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia EIF2AK2 35
  • 77.57 (n)
  • 65.22 (a)
EIF2AK2 36
  • 64 (a)
OneToOne
dog
(Canis familiaris)
Mammalia EIF2AK2 35
  • 76.95 (n)
  • 65.14 (a)
EIF2AK2 36
  • 63 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Eif2ak2 35
  • 70.83 (n)
  • 62.38 (a)
Eif2ak2 16
Eif2ak2 36
  • 61 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia EIF2AK2 35
  • 99.21 (n)
  • 98.73 (a)
EIF2AK2 36
  • 98 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Eif2ak2 35
  • 73.1 (n)
  • 63.19 (a)
oppossum
(Monodelphis domestica)
Mammalia EIF2AK2 36
  • 45 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia EIF2AK2 36
  • 43 (a)
OneToOne
chicken
(Gallus gallus)
Aves EIF2AK2 35
  • 53.43 (n)
  • 42.69 (a)
EIF2AK2 36
  • 35 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia EIF2AK2 36
  • 39 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia eif2ak2 35
  • 51.87 (n)
  • 39.71 (a)
zebrafish
(Danio rerio)
Actinopterygii eif2ak2 35
  • 49.6 (n)
  • 40.96 (a)
eif2ak2 36
  • 29 (a)
OneToMany
pkz 36
  • 28 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea gcn-2 36
  • 8 (a)
ManyToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes GCN2 36
  • 7 (a)
OneToMany
IKS1 38
Species with no ortholog for EIF2AK2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for EIF2AK2 Gene

ENSEMBL:
Gene Tree for EIF2AK2 (if available)
TreeFam:
Gene Tree for EIF2AK2 (if available)

Paralogs for EIF2AK2 Gene

Paralogs for EIF2AK2 Gene

(4) SIMAP similar genes for EIF2AK2 Gene using alignment to 7 proteins:

genes like me logo Genes that share paralogs with EIF2AK2: view

Variants for EIF2AK2 Gene

Sequence variations from dbSNP and Humsavar for EIF2AK2 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type MAF
rs2014498 -- 37,158,933(-) GGGAG(C/G)CAGAG upstream-variant-2KB
rs2254958 -- 37,149,148(-) GGCAT(C/T)GAGGT intron-variant, upstream-variant-2KB, utr-variant-5-prime
rs2270414 -- 37,148,789(-) AAATT(C/T)TGGGG intron-variant, upstream-variant-2KB
rs2287350 -- 37,141,309(-) GCTGG(A/G)TGGTT intron-variant
rs2300822 -- 37,110,741(-) ATCCT(A/G)TTTTA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for EIF2AK2 Gene

Variant ID Type Subtype PubMed ID
nsv511779 CNV Loss 21212237
esv2719931 CNV Deletion 23290073
esv2661177 CNV Deletion 23128226

Variation tolerance for EIF2AK2 Gene

Residual Variation Intolerance Score: 7.51% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.30; 6.67% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for EIF2AK2 Gene

HapMap Linkage Disequilibrium report
EIF2AK2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for EIF2AK2 Gene

Disorders for EIF2AK2 Gene

MalaCards: The human disease database

(12) MalaCards diseases for EIF2AK2 Gene - From: DISEASES, NovoSeek, and GeneCards

Disorder Aliases PubMed IDs
fanconi anemia, complementation group c
  • fanconi anemia complementation group c
rift valley fever
herpes simplex
  • herpesvirus hominis disease
hepatitis c
  • hepatitis c infection
vaccinia
- elite association

Relevant External Links for EIF2AK2

Genetic Association Database (GAD)
EIF2AK2
Human Genome Epidemiology (HuGE) Navigator
EIF2AK2
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
EIF2AK2
genes like me logo Genes that share disorders with EIF2AK2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for EIF2AK2 Gene

Publications for EIF2AK2 Gene

  1. Interaction of double-stranded RNA-dependent protein kinase (PKR) with the death receptor signaling pathway in amyloid beta (Abeta)-treated cells and in APPSLPS1 knock-in mice. (PMID: 19889624) Couturier J. … Page G. (J. Biol. Chem. 2010) 23 67
  2. Intrinsic cellular defenses against virus infection by antiviral type I interferon. (PMID: 20046508) Boo K.H. … Yang J.S. (Yonsei Med. J. 2010) 23 67
  3. Analysis of monomeric and dimeric phosphorylated forms of protein kinase R. (PMID: 20088595) Anderson E. … Cole J.L. (Biochemistry 2010) 23 67
  4. A role for PKR in hematologic malignancies. (PMID: 20232306) Blalock W.L. … Cocco L. (J. Cell. Physiol. 2010) 23 67
  5. TRBP control of PACT-induced phosphorylation of protein kinase R is reversed by stress. (PMID: 18936160) Daher A. … Gatignol A. (Mol. Cell. Biol. 2009) 23 67

Products for EIF2AK2 Gene

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat
  • Pathway & Disease-focused RT² Profiler PCR Arrays
  • QIAGEN qRT-PCR Assays for microRNAs that regulate EIF2AK2
  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat
  • Predesigned siRNA for gene silencing in human,mouse,rat for EIF2AK2
  • Block miRNA regulation of EIF2AK2 using miScript Target Protectors

Sources for EIF2AK2 Gene

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