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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

EIF2A Gene

protein-coding   GIFtS: 55
GCID: GC03P150264

eukaryotic translation initiation factor 2A, 65kDa
 Explore 16 diseases affiliated with
EIF2A via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for EIF2A    

Aliases
for EIF2A gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Eukaryotic Translation Initiation Factor 2A, 65kDa1 2     MSTP0042
EIF-2A1 2     MSTP0892
65 KDa Eukaryotic Translation Initiation Factor 2A2 3     Eukaryotic Translation Initiation Factor 2A2
MST0892     EIF-2A1 2

External Ids:    HGNC: 32541   Entrez Gene: 839392   Ensembl: ENSG000001448957   OMIM: 6092345   UniProtKB: Q9BY443   

Export aliases for EIF2A gene to outside databases

Previous GC identifers: GC03P151748 GC03P147638


Summaries
for EIF2A gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for EIF2A:
EIF2A is a 65-kD protein that catalyzes the formation of puromycin-sensitive 80S preinitiation complexes (Zoll et al.,
2002 (PubMed 12133843)).(supplied by OMIM, Mar 2008)

UniProtKB/Swiss-Prot: EIF2A_HUMAN, Q9BY44
Function: Functions in the early steps of protein synthesis of a small number of specific mRNAs. Acts by directing the
binding of methionyl-tRNAi to 40S ribosomal subunits. In contrast to the eIF-2 complex, it binds methionyl-tRNAi to 40
S subunits in a codon-dependent manner, whereas the eIF-2 complex binds methionyl-tRNAi to 40 S subunits in a
GTP-dependent manner. May act by impiging the expression of specific proteins

Gene Wiki entry for EIF2A


Genomic Views
for EIF2A gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000003.11  NC_018914.1  NT_005612.16  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the EIF2A gene promoter:
         NF-1   Pbx1a   AML1a   POU3F2   GATA-2   C/EBPalpha   CHOP-10   SRY   CBF(2)   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: EIF2A promoter sequence
   Search SABiosciences Chromatin IP Primers for EIF2A

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat EIF2A


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 3q25.1   Ensembl cytogenetic band:  3q25.1   HGNC cytogenetic band: 3q25.1

EIF2A Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
EIF2A gene location

GeneLoc information about chromosome 3         GeneLoc Exon Structure

GeneLoc location for GC03P150264:  view genomic region     (about GC identifiers)

Start:
 150,264,465 bp from pter      End:
 150,303,803 bp from pter
Size:
 39,339 bases      Orientation:
 plus strand

Proteins
for EIF2A gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: EIF2A_HUMAN, Q9BY44 (See protein sequence)
Recommended Name: Eukaryotic translation initiation factor 2A  
Size: 585 amino acids; 64990 Da
Caution: Was initially thought to constitute the ortholog of prokaryotic IF-2 (infB) protein
Sequence caution: Sequence=AAK14926.1; Type=Erroneous initiation; Sequence=AAM83402.1; Type=Frameshift; Positions=82,
90; Sequence=AAQ13506.1; Type=Frameshift; Positions=513; Sequence=AAQ13612.1; Type=Erroneous initiation;
Secondary accessions: A8MPS6 D3DNI9 Q5QTR2 Q7Z4E9 Q8NFM1 Q96EW9 Q96K81
Alternative splicing: 2 isoforms:  Q9BY44-1   Q9BY44-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for EIF2A: NX_Q9BY44

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q9BY44

    • EIF2A Protein expression data from MOPED and PaxDb:    About this image 
    EIF2A Protein Expression
    REFSEQ proteins: NP_114414.2  
    ENSEMBL proteins: 
     ENSP00000420537   ENSP00000417229   ENSP00000419456   ENSP00000385292   ENSP00000418698  
     ENSP00000273435   ENSP00000417575   ENSP00000420495   ENSP00000420493   ENSP00000420611  
     ENSP00000372513  

    Human Recombinant Protein Products for EIF2A: 
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    Novus Biologicals EIF2A Protein
    Novus Biologicals EIF2A Lysates
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    Browse ProSpec Recombinant Proteins
    Uscn Proteins for EIF2A

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm IDA12133843
    GO:0005850eukaryotic translation initiation factor 2 complex IDA12133843

    EIF2A for ontologies           About GeneDecksing



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    Uscn ELISAs and CLIAs for EIF2A

    Protein Domains /
    Families
    for EIF2A gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    EIF2A for domains           About GeneDecksing

    3 InterPro domains/families:
     IPR013979 TIF2A_beta_prop-like
     IPR011387 TIF2A
     IPR015943 WD40/YVTN_repeat-like_dom

    Graphical View of Domain Structure for InterPro Entry Q9BY44

    ProtoNet protein and cluster: Q9BY44

    1 Blocks protein family: IPB013979 Eukaryotic translation initiation factor 2A

    UniProtKB/Swiss-Prot: EIF2A_HUMAN, Q9BY44
    Similarity: Belongs to the WD repeat EIF2A family
    Similarity: Contains 3 WD repeats


    Function
    for EIF2A gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, Sirion Biotech, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, Sirion Biotech, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Molecular Function:

         UniProtKB/Swiss-Prot Summary: EIF2A_HUMAN, Q9BY44
    Function: Functions in the early steps of protein synthesis of a small number of specific mRNAs. Acts by directing the
    binding of methionyl-tRNAi to 40S ribosomal subunits. In contrast to the eIF-2 complex, it binds methionyl-tRNAi to 40
    S subunits in a codon-dependent manner, whereas the eIF-2 complex binds methionyl-tRNAi to 40 S subunits in a
    GTP-dependent manner. May act by impiging the expression of specific proteins

         Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000049tRNA binding IMP12133843
    GO:0003743translation initiation factor activity IMP12133843
    GO:0005515protein binding IPI18816594
    GO:0043022ribosome binding IMP12133843
         
    EIF2A for ontologies           About GeneDecksing


    Animal Models:
       inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for EIF2A 

    miRNA
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    hsa-miR-522 hsa-miR-1261 hsa-miR-507 hsa-miR-224* hsa-miR-511 hsa-miR-629 hsa-miR-3662 hsa-miR-29a*
    SwitchGear 3'UTR luciferase reporter plasmid: EIF2A 3' UTR sequence
    Inhib. RNA
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    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for EIF2A (see all 7)
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    OriGene siRNA: EIF2A
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    Gene Editing
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    Clone
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    Cell Line
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    In Situ Assay
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    Pathways & Interactions
    for EIF2A gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways  About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1TGF-beta receptor signaling
    		TGF-beta receptor signaling1.00
    2IL-6 Signaling Pathway
    		IL-6 Signaling Pathway1.00


    2 BioSystems Pathways for EIF2A 
        IL-6 Signaling Pathway
    TGF-beta receptor signaling


    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for EIF2A

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/131 Interacting proteins for EIF2A (Q9BY442, 3 ENSP000004172294) via UniProtKB, MINT, STRING, and/or I2D (see all 131)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    EEF2P136392, 3, ENSP000003079404MINT-6542674 I2D: score=1 STRING: ENSP00000307940
    RPL8P629172, 3, ENSP000002625844MINT-6542674 I2D: score=1 STRING: ENSP00000262584
    RPS13P622772, 3, ENSP000002281404MINT-6542674 I2D: score=1 STRING: ENSP00000228140
    EEF1A1P681042, 3MINT-6542674 I2D: score=2 
    RPL10AP629062, 3MINT-6542674 I2D: score=1 
    About this table

    Gene Ontology (GO): 5/7 biological process terms (GO ID links to tree view) (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006412translation ----
    GO:0006413translational initiation ----
    GO:0006417regulation of translation IMP12133843
    GO:0006468protein phosphorylation IEA--
    GO:0009967positive regulation of signal transduction IEA--

    EIF2A for ontologies           About GeneDecksing



    Drugs & Compounds
    for EIF2A gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for EIF2A

    1 HMDB Compound for EIF2A    About this table
    CompoundSynonyms CAS #PubMed Ids
    Guanosine triphosphate5'-GTP (see all 10)86-01-1--
    Search CenterWatch for drugs/clinical trials and news about EIF2A 

    Transcripts
    for EIF2A gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, Sirion Biotech, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for EIF2A gene: 
    NM_032025.3  

    Unigene Cluster for EIF2A:

    Eukaryotic translation initiation factor 2A, 65kDa
    Hs.655782  [show with all ESTs]
    Unigene Representative Sequence: NM_032025
    17 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000463863 ENST00000487799 ENST00000460851(uc003eya.3 uc003eyb.3 uc003eyc.3 uc011bnv.2 uc011bnw.2)
    ENST00000473499 ENST00000494558 ENST00000474505 ENST00000406576 ENST00000482093
    ENST00000469331 ENST00000273435 ENST00000490505 ENST00000462221 ENST00000477551(uc003eyd.3)
    ENST00000472926 ENST00000465535 ENST00000482471 ENST00000383043

    miRNA
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    8 QIAGEN miScript miRNA Assays for microRNAs that regulate EIF2A:
    hsa-miR-522 hsa-miR-1261 hsa-miR-507 hsa-miR-224* hsa-miR-511 hsa-miR-629 hsa-miR-3662 hsa-miR-29a*
    SwitchGear 3'UTR luciferase reporter plasmid: EIF2A 3' UTR sequence
    Inhib. RNA
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    OriGene shRNA RFP: EIF2A
    OriGene siRNA: EIF2A
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    Clone
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    Primer
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    Additional cDNA sequence: 

    AF109358.1 AF172818.1 AF212241.1 AF497978.1 AK027356.1 AK293993.1 AK298586.1 AL833101.1 
    BC011885.1 BX647951.1 

    24/31 DOTS entries (see all 31):

    DT.452574  DT.92046475  DT.101983860  DT.100827279  DT.120912442  DT.92476267  DT.40121380  DT.100827283 
    DT.120912640  DT.311655  DT.120912587  DT.91647719  DT.87016647  DT.120912588  DT.100827275  DT.120912426 
    DT.120912427  DT.120912589  DT.120912635  DT.92002107  DT.100757070  DT.120912429  DT.120912672  DT.92339977 

    24/445 AceView cDNA sequences (see all 445):

    BM990766 BX423544 CB115122 BX455882 AA401784 BM470054 BQ924674 BM667811 
    CK820782 BG033953 CR607540 AA903809 CR601134 H06861 BX281596 BX385914 
    BM848252 BM741537 BI467294 BM715175 BQ777577 BU154926 AA128197 AW272664 

    GeneLoc Exon Structure


    Expression
    for EIF2A gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    EIF2A expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: TAAATGAATA
    EIF2A Expression
    About this image
    See EIF2A Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for EIF2A

    SOURCE GeneReport for Unigene cluster: Hs.655782

    UniProtKB/Swiss-Prot: EIF2A_HUMAN, Q9BY44
    Tissue specificity: Widely expressed. Expressed at higher level in pancreas, heart, brain and placenta

        SABiosciences Expression via Pathway-Focused PCR Array including EIF2A: 
              Unfolded Protein Response in human mouse rat

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    In Situ
    Assay Products:     
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    Orthologs
    for EIF2A gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of eukaryotes.

    Orthologs for EIF2A gene from 10/33 species (see all 33)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    mouse
    (Mus musculus)    		 Mammalia Eif2a1 , 5 eukaryotic translation initiation factor 2A1, 5 89.73(n)1
    93.46(a)1    		   3 (28.58 cM)5
    2293171  NM_001005509.21  NP_001005509.11 
     585258215 
    chicken
    (Gallus gallus)    		 Aves EIF2A1 eukaryotic translation initiation factor 2A, 65kDa 79.89(n)
    84.62(a)    		   425042  NM_001031323.1  NP_001026494.1 
    lizard
    (Anolis carolinensis)    		 Reptilia EIF2A6
    --
    		 --
    		 79(a)
    10(a)
    		 1 ↔ 1
    possible ortholog
    		 3(18369377-18384582)
    GL343307.1(1301747-1303336)
    African clawed frog
    (Xenopus laevis)    		 Amphibia LOC3984452 hypothetical protein LOC398445 76.79(n)    BC044026.1 
    zebrafish
    (Danio rerio)    		 Actinopterygii BM530352.12   -- 73.28(n)    BM530352.1 
    fruit fly
    (Drosophila melanogaster)    		 Insecta CG74141 CG7414 46.97(n)
    40.21(a)    		   40431  NM_141108.2  NP_649365.1 
    worm
    (Caenorhabditis elegans)    		 Secernentea E04D5.11 Protein E04D5.1 49.81(n)
    40.67(a)    		   174606  NM_063838.3  NP_496239.2 
    baker's yeast
    (Saccharomyces cerevisiae)    		 Saccharomycetes (YGR054W)4
    YGR054W1    		 Eukaryotic initiation factor (eIF) 2A; associates specifically with both 40S subunits and 80 S ribosomes, and interacts genetically with both eIF5b and eIF4E; homologous to mammalian eIF2A less4
    hypothetical protein1    		 43.59(n)1
    33.08(a)1    		   7(596693-598621)4
    8529451, 4  NP_011568.31  NP_011568.14 
    thale cress
    (Arabidopsis thaliana)    		 eudicotyledons AT1G731806
    		 eukaryotic translation initiation factor eIF2A-lik...
    		 31(a)
    		 1 ↔ 1
    		 1(27517916-27521649)
    rice
    (Oryza sativa)    		 Liliopsida --
    		 eukaryotic translation initiation factor 2A, putat...
    		 31(a)
    		 1 ↔ 1
    		 2(23743163-23747367)


    ENSEMBL Gene Tree for EIF2A (if available)
    TreeFam Gene Tree for EIF2A (if available) 

    Paralogs
    for EIF2A gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for EIF2A gene
    WIBG2  
    1 SIMAP similar gene for EIF2A using alignment to 10 protein entries:     EIF2A_HUMAN (see all proteins):
    ZNF701

    EIF2A for paralogs           About GeneDecksing


    5 Pseudogenes.org Pseudogenes for EIF2A
    PGOHUM00000238758 PGOHUM00000238759 PGOHUM00000233074 PGOHUM00000233077 PGOHUM00000233079


    Genomic Variants
    for EIF2A gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/555 NCBI SNPs in EIF2A are shown (see all 555)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 3 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs58534831,2
    		C,F--147654192(+) GGGGGA/-AAAAG 1 -- int1 trp32Minor allele frequency- -:0.50NA 4
    rs1865081121,2
    		--150266560(+) TGTAAA/GAGCTT 1 -- int10--------
    rs1901724661,2
    		--150266593(+) TCTTCA/GTATTC 1 -- int10--------
    rs1818254591,2
    		--150266634(+) TGGTCC/TGATTC 1 -- int10--------
    rs1428293471,2
    		--150266639(+) CGATTC/TACACT 1 -- int10--------
    rs98561811,2
    		C,F,A,H--150266660(+) AGGATT/CAGGAT 1 -- int113Minor allele frequency- C:0.37NS EA NA CSA WA 790
    rs1153922701,2
    		F--150266793(+) ATCTTT/CTGTTA 1 -- int11Minor allele frequency- C:0.03NA 120
    rs1870430721,2
    		--150266828(+) GCTGTG/TAATAA 1 -- int10--------
    rs114385481,2
    		C--150266911(+) TTTTTT/-AAACT 1 -- int11Minor allele frequency- -:0.00NA 2
    rs1474035811,2
    		--150266930(+) CTCGTA/GTAACC 1 -- int10--------

    HapMap Linkage Disequilibrium report for EIF2A (150264465 - 150303803 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for EIF2A: --

    SABiosciences Cancer Mutation PCR Assays
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    Disorders / Diseases
    for EIF2A gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    EIF2A for disorders           About GeneDecksing

    OMIM gene information: 609234    OMIM disorders: --

    16 diseases for EIF2A:    About MalaCards
    herpes simplex    brain ischemia    squamous cell carcinoma    multiple myeloma
    hepatitis b    vaccinia    ischemia    myeloma
    breast cancer    hepatitis    hypoxia    melanoma
    carcinoma    pancreatitis    malaria    neuronitis

    Human Genome Epidemiology (HuGE) Navigator: EIF2A (5 documents)

    Export disorders for EIF2A gene to outside databases

    Publications
    for EIF2A gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for EIF2A gene, integrated from 9 sources (see all 62):
    (articles sorted by number of sources associating them with EIF2A)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Characterization of mammalian eIF2A and identification of the yeast homolog. (PubMed id 12133843)1, 2, 3 Zoll W.L.... Merrick W.C. (2002)
    2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    3. Mechanism and regulation of eukaryotic protein synthe sis. (PubMed id 1620067)1, 3 Merrick W.C. (1992)
    4. Diallyl tetrasulfane activates both the eIF2a and Nrf2 /HO-1 pathways. (PubMed id 23046979)1 Saidu N.E....Montenarh M. (2013)
    5. A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (2012)
    6. Methods for quantification of in vivo changes in prote in ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724)1 Udeshi N.D....Carr S.A. (2012)
    7. A high-throughput approach for measuring temporal chan ges in the interactome. (PubMed id 22863883)1 Kristensen A.R....Foster L.J. (2012)
    8. Protein kinase PKR amplification of interferon b induc tion occurs through initiation factor eIF-2a-mediated translational control. (PubMed id 22948139)1 McAllister C.S....Samuel C.E. (2012)
    9. A subunit of eukaryotic translation initiation factor 2a-phosphatase (CreP/PPP1R15B) regulates membrane traffic. (PubMed id 22915583)1 Kloft N....Husmann M. (2012)
    10. Inhibition of nonsense-mediated RNA decay by the tumo r microenvironment promotes tumorigenesis. (PubMed id 21730287)1 Wang D....Gardner L.B. (2011)

    External Searches for EIF2A gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
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      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
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    Genome Databases showing EIF2A gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 83939 HGNC: 3254 AceView: eIF2A Ensembl:ENSG00000144895 euGenes: HUgn83939
    ECgene: EIF2A H-InvDB: EIF2A

    Other Databases showing EIF2A gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing EIF2A gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for EIF2A Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for EIF2A gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for EIF2A gene:
    Search GeneIP for patents involving EIF2A

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    About This Section

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