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EIF2A Gene

protein-coding   GIFtS: 60
GCID: GC03P150264

Eukaryotic Translation Initiation Factor 2A, 65kDa

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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Eukaryotic Translation Initiation Factor 2A, 65kDa1 2     MSTP0042
65 KDa Eukaryotic Translation Initiation Factor 2A2 3     MSTP0892
EIF-2A2     Eukaryotic Translation Initiation Factor 2A2
MST0892     eIF-2A3

External Ids:    HGNC: 32541   Entrez Gene: 839392   Ensembl: ENSG000001448957   OMIM: 6092345   UniProtKB: Q9BY443   

Export aliases for EIF2A gene to outside databases

Previous GC identifers: GC03P151748 GC03P147638


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for EIF2A Gene:
EIF2A is a 65-kD protein that catalyzes the formation of puromycin-sensitive 80S preinitiation complexes (Zoll et
al., 2002 (PubMed 12133843)).(supplied by OMIM, Mar 2008)

GeneCards Summary for EIF2A Gene:
EIF2A (eukaryotic translation initiation factor 2A, 65kDa) is a protein-coding gene. GO annotations related to this gene include ribosome binding and translation initiation factor activity.

UniProtKB/Swiss-Prot: EIF2A_HUMAN, Q9BY44
Function: Functions in the early steps of protein synthesis of a small number of specific mRNAs. Acts by directing
the binding of methionyl-tRNAi to 40S ribosomal subunits. In contrast to the eIF-2 complex, it binds
methionyl-tRNAi to 40 S subunits in a codon-dependent manner, whereas the eIF-2 complex binds methionyl-tRNAi to
40 S subunits in a GTP-dependent manner. May act by impiging the expression of specific proteins

Gene Wiki entry for EIF2A Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000003.11  NC_018914.2  NT_005612.17  
Regulatory elements:
   Regulatory transcription factor binding sites in the EIF2A gene promoter:
         NF-1   Pbx1a   AML1a   POU3F2   GATA-2   C/EBPalpha   CHOP-10   SRY   CBF(2)   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidEIF2A promoter sequence
   Search Chromatin IP Primers for EIF2A

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat EIF2A


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 3q25.1   Ensembl cytogenetic band:  3q25.1   HGNC cytogenetic band: 3q25.1

EIF2A Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
EIF2A gene location

GeneLoc information about chromosome 3         GeneLoc Exon Structure

GeneLoc location for GC03P150264:  view genomic region     (about GC identifiers)

Start:
150,264,465 bp from pter      End:
150,303,803 bp from pter
Size:
39,339 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: EIF2A_HUMAN, Q9BY44 (See protein sequence)
Recommended Name: Eukaryotic translation initiation factor 2A  
Size: 585 amino acids; 64990 Da
Caution: Was initially thought to constitute the ortholog of prokaryotic IF-2 (infB) protein
Sequence caution: Sequence=AAK14926.1; Type=Erroneous initiation; Sequence=AAM83402.1; Type=Frameshift;
Positions=82, 90; Sequence=AAQ13506.1; Type=Frameshift; Positions=513; Sequence=AAQ13612.1; Type=Erroneous
initiation;
Secondary accessions: A8MPS6 D3DNI9 Q5QTR2 Q7Z4E9 Q8NFM1 Q96EW9 Q96K81
Alternative splicing: 2 isoforms:  Q9BY44-1   Q9BY44-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for EIF2A: NX_Q9BY44

Explore proteomics data for EIF2A at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys115, Lys127
  • Modification sites at PhosphoSitePlus

  • See EIF2A Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_114414.2  
    ENSEMBL proteins: 
     ENSP00000420537   ENSP00000417229   ENSP00000419456   ENSP00000385292   ENSP00000418698  
     ENSP00000273435   ENSP00000417575   ENSP00000420495   ENSP00000420493   ENSP00000420611  
     ENSP00000372513  

    EIF2A Human Recombinant Protein Products:

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    Cloud-Clone Corp. Proteins for EIF2A

     
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    antibodies-online proteins for EIF2A (4 products) 

     
    antibodies-online peptides for EIF2A

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    antibodies-online kits for EIF2A (2 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    4 InterPro protein domains:
     IPR013979 TIF_beta_prop-like
     IPR011387 TIF2A
     IPR017986 WD40_repeat_dom
     IPR015943 WD40/YVTN_repeat-like_dom

    Graphical View of Domain Structure for InterPro Entry Q9BY44

    ProtoNet protein and cluster: Q9BY44

    1 Blocks protein domain: IPB013979 Eukaryotic translation initiation factor 2A

    UniProtKB/Swiss-Prot: EIF2A_HUMAN, Q9BY44
    Similarity: Belongs to the WD repeat EIF2A family
    Similarity: Contains 3 WD repeats


    Find genes that share domains with EIF2A           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: EIF2A_HUMAN, Q9BY44
    Function: Functions in the early steps of protein synthesis of a small number of specific mRNAs. Acts by directing
    the binding of methionyl-tRNAi to 40S ribosomal subunits. In contrast to the eIF-2 complex, it binds
    methionyl-tRNAi to 40 S subunits in a codon-dependent manner, whereas the eIF-2 complex binds methionyl-tRNAi to
    40 S subunits in a GTP-dependent manner. May act by impiging the expression of specific proteins

         Gene Ontology (GO): 4 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000049tRNA binding IMP12133843
    GO:0003743translation initiation factor activity IMP12133843
    GO:0005515protein binding IPI18816594
    GO:0043022ribosome binding IMP12133843
         
    Find genes that share ontologies with EIF2A           About GenesLikeMe


    Animal Models:
       genOway: Develop your customized and physiologically relevant rodent model for EIF2A

    miRNA
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    miRTarBase miRNAs that target EIF2A:
    hsa-mir-16-5p (MIRT031752), hsa-mir-186-5p (MIRT044991), hsa-mir-30c-5p (MIRT048013)

    Block miRNA regulation of human, mouse, rat EIF2A using miScript Target Protectors
    8 qRT-PCR Assays for microRNAs that regulate EIF2A:
    hsa-miR-522 hsa-miR-1261 hsa-miR-507 hsa-miR-224* hsa-miR-511 hsa-miR-629 hsa-miR-3662 hsa-miR-29a*
    SwitchGear 3'UTR luciferase reporter plasmidEIF2A 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat EIF2A

    Gene Editing
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol3
    endoplasmic reticulum2
    nucleus2
    mitochondrion1
    peroxisome1

    Gene Ontology (GO): 4 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005615extracellular space IDA--
    GO:0005737cytoplasm IDA12133843
    GO:0005850eukaryotic translation initiation factor 2 complex IDA12133843
    GO:0072562blood microparticle IDA--

    Find genes that share ontologies with EIF2A           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for EIF2A About    
    See pathways by source

    SuperPathContained pathways About
    1TGF-beta receptor signaling
    TGF-beta receptor signaling
    2IL-6 Signaling Pathway
    IL-6 Signaling Pathway


    2 BioSystems Pathways for EIF2A
        IL-6 Signaling Pathway
    TGF-beta receptor signaling



        Pathway & Disease-focused RT2 Profiler PCR Array including EIF2A: 
              Unfolded Protein Response in human mouse rat

    Interactions:

        Search GeneGlobe Interaction Network for EIF2A

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for EIF2A (Q9BY442, 3 ENSP000004172294) via UniProtKB, MINT, STRING, and/or I2D (see all 240)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    EEF2P136392, 3, ENSP000003079404MINT-6542674 I2D: score=1 STRING: ENSP00000307940
    RPS13P622772, 3, ENSP000002281404MINT-6542674 I2D: score=1 STRING: ENSP00000228140
    RPS4XP627012, 3, ENSP000003627444MINT-6542674 I2D: score=1 STRING: ENSP00000362744
    RPS8P622412, 3, ENSP000003798884MINT-6542674 I2D: score=1 STRING: ENSP00000379888
    RPL10AP629062, 3MINT-6542674 I2D: score=1 
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006412translation ----
    GO:0006417regulation of translation IMP12133843
    GO:0006468protein phosphorylation IEA--
    GO:0009967positive regulation of signal transduction IEA--
    GO:0032933SREBP signaling pathway IEA--

    Find genes that share ontologies with EIF2A           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for EIF2A

    1 HMDB Compound for EIF2A    About this table
    CompoundSynonyms CAS #PubMed Ids
    Guanosine triphosphate5'-GTP (see all 10)86-01-1--



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for EIF2A gene: 
    NM_032025.3  

    Unigene Cluster for EIF2A:

    Eukaryotic translation initiation factor 2A, 65kDa
    Hs.655782  [show with all ESTs]
    Unigene Representative Sequence: NM_032025
    17 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000463863 ENST00000487799 ENST00000460851(uc003eya.3 uc003eyb.3 uc003eyc.3 uc011bnv.2 uc011bnw.2)
    ENST00000473499 ENST00000494558 ENST00000474505 ENST00000406576 ENST00000482093
    ENST00000469331 ENST00000273435 ENST00000490505 ENST00000462221 ENST00000477551(uc003eyd.3)
    ENST00000472926 ENST00000465535 ENST00000482471 ENST00000383043
    miRNA
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    8 qRT-PCR Assays for microRNAs that regulate EIF2A:
    hsa-miR-522 hsa-miR-1261 hsa-miR-507 hsa-miR-224* hsa-miR-511 hsa-miR-629 hsa-miR-3662 hsa-miR-29a*
    SwitchGear 3'UTR luciferase reporter plasmidEIF2A 3' UTR sequence
    Inhib. RNA
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      QuantiFast Probe-based Assays in human, mouse, rat EIF2A

    Additional mRNA sequence: 

    AF109358.1 AF172818.1 AF212241.1 AF497978.1 AK027356.1 AK293993.1 AK298586.1 AL833101.1 
    BC011885.1 BX647951.1 

    Selected DOTS entries (see all 31):

    DT.452574  DT.92046475  DT.101983860  DT.100827279  DT.120912442  DT.92476267  DT.40121380  DT.100827283 
    DT.120912640  DT.311655  DT.120912587  DT.91647719  DT.87016647  DT.120912588  DT.100827275  DT.120912426 
    DT.120912427  DT.120912589  DT.120912635  DT.92002107  DT.97780537  DT.100757070  DT.120912429  DT.120912672 

    Selected AceView cDNA sequences (see all 445):

    BM715175 BX358106 BQ716964 BM990766 CB115122 CR608205 CR601134 BQ431084 
    BU192433 AI628597 AW272664 CA774501 AA903809 AW272652 AA355821 AI261739 
    BQ015383 BE782655 BX281596 BQ924674 CR607540 BU154926 H06861 BG033953 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    EIF2A expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TAAATGAATA
    EIF2A Expression
    About this image


    EIF2A expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 14) fully expand
     
     Bone (Muscoskeletal System)
             Bone Marrow
     
     Colon (Gastrointestinal Tract)
     
     Kidney (Urinary System)
     
     Uterus (Reproductive System)
     
     Lung (Respiratory System)
    EIF2A Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    EIF2A Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.655782

    UniProtKB/Swiss-Prot: EIF2A_HUMAN, Q9BY44
    Tissue specificity: Widely expressed. Expressed at higher level in pancreas, heart, brain and placenta

        Pathway & Disease-focused RT2 Profiler PCR Array including EIF2A: 
              Unfolded Protein Response in human mouse rat

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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for EIF2A

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of eukaryotes.

    Orthologs for EIF2A gene from Selected species (see all 22)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Eif2a1 , 5 eukaryotic translation initiation factor 2A1, 5 89.69(n)1
    93.5(a)1
      3 (28.58 cM)5
    2293171  NM_001005509.21  NP_001005509.11 
     585258215 
    chicken
    (Gallus gallus)
    Aves EIF2A1 eukaryotic translation initiation factor 2A, 65kDa 79.93(n)
    84.47(a)
      425042  NM_001031323.1  NP_001026494.1 
    lizard
    (Anolis carolinensis)
    Reptilia EIF2A6
    eukaryotic translation initiation factor 2A, 65kDa...
    79(a)
    1 ↔ 1
    3(18367033-18392145)
    African clawed frog
    (Xenopus laevis)
    Amphibia LOC3984452 hypothetical protein LOC398445 76.79(n)    BC044026.1 
    zebrafish
    (Danio rerio)
    Actinopterygii BM530352.12   -- 73.28(n)    BM530352.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG74141 CG7414 46.99(n)
    39.89(a)
      40431  NM_141108.2  NP_649365.1 
    worm
    (Caenorhabditis elegans)
    Secernentea E04D5.11 E04D5.1 49.68(n)
    40.3(a)
      174606  NM_063838.4  NP_496239.2 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes (YGR054W)4
    YGR054W1
    Eukaryotic initiation factor (eIF) 2A; associates specifically more4
    YGR054W1
    43.88(n)1
    34.57(a)1
      7(596693-598621)4
    8529451, 4  NP_011568.31  NP_011568.14 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons AT1G731801 AT1G73180 46.49(n)
    38(a)
      843652  NM_105977.3  NP_565058.1 


    ENSEMBL Gene Tree for EIF2A (if available)
    TreeFam Gene Tree for EIF2A (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for EIF2A gene
    1 SIMAP similar gene for EIF2A using alignment to 10 protein entries:     EIF2A_HUMAN (see all proteins):
    ZNF701

    Find genes that share paralogs with EIF2A           About GenesLikeMe


    5 Pseudogenes.org Pseudogenes for EIF2A
    PGOHUM00000238758 PGOHUM00000238759 PGOHUM00000233074 PGOHUM00000233077 PGOHUM00000233079


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for EIF2A (see all 664)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 3 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1865081121,2
    --150266560(+) TGTAAA/GAGCTT 1 -- int10--------
    rs1901724661,2
    --150266593(+) TCTTCA/GTATTC 1 -- int10--------
    rs1818254591,2
    --150266634(+) TGGTCC/TGATTC 1 -- int10--------
    rs1428293471,2
    --150266639(+) CGATTC/TACACT 1 -- int10--------
    rs98561811,2
    C,F,A,H--150266660(+) AGGATT/CAGGAT 1 -- int113Minor allele frequency- C:0.37NS EA NA CSA WA 790
    rs1153922701,2
    F--150266793(+) ATCTTT/CTGTTA 1 -- int11Minor allele frequency- C:0.03NA 120
    rs1870430721,2
    --150266828(+) GCTGTG/TAATAA 1 -- int10--------
    rs114385481,2
    C--150266910(+) TTTTTT/-AAACT 1 -- int11Minor allele frequency- -:0.00NA 2
    rs1474035811,2
    C--150266930(+) CTCGTA/GTAACC 1 -- int10--------
    rs2009051851,2
    --150267004(+) TTCTT-/TCTTTCT 1 -- int10--------

    HapMap Linkage Disequilibrium report for EIF2A (150264465 - 150303803 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for EIF2A:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv507130CNV Insertion20534489
    nsv511101CNV Complex20534489

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing EIF2A
    DNA2.0 Custom Variant and Variant Library Synthesis for EIF2A

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 609234    OMIM disorders: --


    Find genes that share disorders with EIF2A           About GenesLikeMe

    Genetic Association Database (GAD): EIF2A
    Human Genome Epidemiology (HuGE) Navigator: EIF2A (5 documents)

    Export disorders for EIF2A gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for EIF2A gene, integrated from 10 sources (see all 71):
    (articles sorted by number of sources associating them with EIF2A)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Characterization of mammalian eIF2A and identification of the yeast homolog. (PubMed id 12133843)1, 2, 3 Zoll W.L.... Merrick W.C. (J. Biol. Chem. 2002)
    2. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1, 4 Bailey S.D....Anand S. (Diabetes Care 2010)
    3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    4. Mechanism and regulation of eukaryotic protein synthesis. (PubMed id 1620067)1, 3 Merrick W.C. (Microbiol. Rev. 1992)
    5. Eukaryotic initiation factor 2I+ phosphorylation mediates fetal hemoglobin induction through a post-transcriptional mechanism. (PubMed id 23690448)1 Hahn C.K. and Lowrey C.H. (Blood 2013)
    6. Diallyl tetrasulfane activates both the eIF2I+ and Nrf2/HO-1 pathways. (PubMed id 23046979)1 Saidu N.E....Montenarh M. (Biochim. Biophys. Acta 2013)
    7. PERK/eIF2I+ signaling protects therapy resistant hypoxic cells through induction of glutathione synthesis and protection against ROS. (PubMed id 23471998)1 Rouschop K.M....Wouters B.G. (Proc. Natl. Acad. Sci. U.S.A. 2013)
    8. A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (Cell 2012)
    9. A high-throughput approach for measuring temporal changes in the interactome. (PubMed id 22863883)1 Kristensen A.R....Foster L.J. (Nat. Methods 2012)
    10. A subunit of eukaryotic translation initiation factor 2I+-phosphatase (CreP/PPP1R15B) regulates membrane traffic. (PubMed id 22915583)1 Kloft N....Husmann M. (J. Biol. Chem. 2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 83939 HGNC: 3254 AceView: eIF2A Ensembl:ENSG00000144895 euGenes: HUgn83939
    ECgene: EIF2A H-InvDB: EIF2A

    (According to HUGE)
    About This Section

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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for EIF2A Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for EIF2A gene:
    Search GeneIP for patents involving EIF2A

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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