Aliases for EIF2A Gene
External Ids for EIF2A Gene
Previous GeneCards Identifiers for EIF2A Gene
EIF2A is a 65-kD protein that catalyzes the formation of puromycin-sensitive 80S preinitiation complexes (Zoll et al., 2002 [PubMed 12133843]).[supplied by OMIM, Mar 2008]
GeneCards Summary for EIF2A Gene
EIF2A (Eukaryotic Translation Initiation Factor 2A, 65kDa) is a Protein Coding gene. Among its related pathways are IL-6 Signaling Pathway and TGF-beta receptor signaling. GO annotations related to this gene include translation initiation factor activity and ribosome binding.
UniProtKB/Swiss-Prot for EIF2A Gene
Functions in the early steps of protein synthesis of a small number of specific mRNAs. Acts by directing the binding of methionyl-tRNAi to 40S ribosomal subunits. In contrast to the eIF-2 complex, it binds methionyl-tRNAi to 40 S subunits in a codon-dependent manner, whereas the eIF-2 complex binds methionyl-tRNAi to 40 S subunits in a GTP-dependent manner. May act by impiging the expression of specific proteins.