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Aliases for EIF2A Gene

Aliases for EIF2A Gene

  • Eukaryotic Translation Initiation Factor 2A, 65kDa 2 3
  • 65 KDa Eukaryotic Translation Initiation Factor 2A 3 4
  • EIF-2A 3 4
  • Eukaryotic Translation Initiation Factor 2A 3
  • MSTP004 3
  • MSTP089 3
  • MST089 3
  • CDA02 3

External Ids for EIF2A Gene

Previous GeneCards Identifiers for EIF2A Gene

  • GC03P151748
  • GC03P150264
  • GC03P147638

Summaries for EIF2A Gene

Entrez Gene Summary for EIF2A Gene

  • EIF2A is a 65-kD protein that catalyzes the formation of puromycin-sensitive 80S preinitiation complexes (Zoll et al., 2002 [PubMed 12133843]).[supplied by OMIM, Mar 2008]

GeneCards Summary for EIF2A Gene

EIF2A (Eukaryotic Translation Initiation Factor 2A, 65kDa) is a Protein Coding gene. Among its related pathways are IL-6 Signaling Pathway and TGF-beta receptor signaling. GO annotations related to this gene include translation initiation factor activity and ribosome binding.

UniProtKB/Swiss-Prot for EIF2A Gene

  • Functions in the early steps of protein synthesis of a small number of specific mRNAs. Acts by directing the binding of methionyl-tRNAi to 40S ribosomal subunits. In contrast to the eIF-2 complex, it binds methionyl-tRNAi to 40 S subunits in a codon-dependent manner, whereas the eIF-2 complex binds methionyl-tRNAi to 40 S subunits in a GTP-dependent manner. May act by impiging the expression of specific proteins.

Gene Wiki entry for EIF2A Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for EIF2A Gene

Genomics for EIF2A Gene

Regulatory Elements for EIF2A Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for EIF2A Gene

Start:
150,546,678 bp from pter
End:
150,586,016 bp from pter
Size:
39,339 bases
Orientation:
Plus strand

Genomic View for EIF2A Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for EIF2A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for EIF2A Gene

Proteins for EIF2A Gene

  • Protein details for EIF2A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9BY44-EIF2A_HUMAN
    Recommended name:
    Eukaryotic translation initiation factor 2A
    Protein Accession:
    Q9BY44
    Secondary Accessions:
    • A8MPS6
    • B4DF96
    • B4DQ14
    • D3DNI9
    • Q5QTR2
    • Q7Z4E9
    • Q8NFM1
    • Q96EW9
    • Q96K81

    Protein attributes for EIF2A Gene

    Size:
    585 amino acids
    Molecular mass:
    64990 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAK14926.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=AAM83402.1; Type=Frameshift; Positions=82, 90; Evidence={ECO:0000305}; Sequence=AAQ13506.1; Type=Frameshift; Positions=513; Evidence={ECO:0000305}; Sequence=AAQ13612.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for EIF2A Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for EIF2A Gene

Proteomics data for EIF2A Gene at MOPED

Post-translational modifications for EIF2A Gene

  • Ubiquitination at Lys115 and Lys127
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for EIF2A Gene

Domains for EIF2A Gene

Graphical View of Domain Structure for InterPro Entry

Q9BY44

UniProtKB/Swiss-Prot:

EIF2A_HUMAN :
  • Q9BY44
Family:
  • Belongs to the WD repeat EIF2A family.
Similarity:
  • Contains 7 WD repeats.
genes like me logo Genes that share domains with EIF2A: view

No data available for Gene Families for EIF2A Gene

Function for EIF2A Gene

Molecular function for EIF2A Gene

UniProtKB/Swiss-Prot Function: Functions in the early steps of protein synthesis of a small number of specific mRNAs. Acts by directing the binding of methionyl-tRNAi to 40S ribosomal subunits. In contrast to the eIF-2 complex, it binds methionyl-tRNAi to 40 S subunits in a codon-dependent manner, whereas the eIF-2 complex binds methionyl-tRNAi to 40 S subunits in a GTP-dependent manner. May act by impiging the expression of specific proteins.

Gene Ontology (GO) - Molecular Function for EIF2A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000049 tRNA binding IMP 12133843
GO:0003743 translation initiation factor activity IMP 12133843
GO:0005515 protein binding IPI 18816594
GO:0043022 ribosome binding IMP 12133843
genes like me logo Genes that share ontologies with EIF2A: view

Animal Model Products

CRISPR Products

miRNA for EIF2A Gene

miRTarBase miRNAs that target EIF2A

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for EIF2A Gene

Localization for EIF2A Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for EIF2A Gene COMPARTMENTS Subcellular localization image for EIF2A gene
Compartment Confidence
cytosol 3
endoplasmic reticulum 2
nucleus 2
mitochondrion 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for EIF2A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005615 extracellular space IDA 22664934
GO:0005737 cytoplasm IDA 12133843
GO:0005850 eukaryotic translation initiation factor 2 complex IDA 12133843
GO:0072562 blood microparticle IDA 22516433
genes like me logo Genes that share ontologies with EIF2A: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for EIF2A Gene

Pathways for EIF2A Gene

genes like me logo Genes that share pathways with EIF2A: view

Pathways by source for EIF2A Gene

2 BioSystems pathways for EIF2A Gene

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays

Gene Ontology (GO) - Biological Process for EIF2A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006412 translation --
GO:0006413 translational initiation IEA --
GO:0006417 regulation of translation IMP 12133843
GO:0006468 protein phosphorylation IEA --
GO:0009967 positive regulation of signal transduction IEA --
genes like me logo Genes that share ontologies with EIF2A: view

Compounds for EIF2A Gene

(1) HMDB Compounds for EIF2A Gene

Compound Synonyms Cas Number PubMed IDs
Guanosine triphosphate
  • 5'-GTP
86-01-1
genes like me logo Genes that share compounds with EIF2A: view

Transcripts for EIF2A Gene

Unigene Clusters for EIF2A Gene

Eukaryotic translation initiation factor 2A, 65kDa:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for EIF2A

Primer Products

  • OriGene qSTAR qPCR primer pairs in human,mouse,rat for EIF2A

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for EIF2A Gene

No ASD Table

Relevant External Links for EIF2A Gene

GeneLoc Exon Structure for
EIF2A
ECgene alternative splicing isoforms for
EIF2A

Expression for EIF2A Gene

mRNA expression in normal human tissues for EIF2A Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for EIF2A Gene

SOURCE GeneReport for Unigene cluster for EIF2A Gene Hs.655782

mRNA Expression by UniProt/SwissProt for EIF2A Gene

Q9BY44-EIF2A_HUMAN
Tissue specificity: Widely expressed. Expressed at higher level in pancreas, heart, brain and placenta.
genes like me logo Genes that share expressions with EIF2A: view

In Situ Assay Products

No data available for mRNA differential expression in normal tissues for EIF2A Gene

Orthologs for EIF2A Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for EIF2A Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia EIF2A 35
  • 99.66 (n)
  • 99.32 (a)
EIF2A 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia EIF2A 35
  • 92.42 (n)
  • 93.5 (a)
EIF2A 36
  • 94 (a)
OneToOne
dog
(Canis familiaris)
Mammalia EIF2A 35
  • 93.45 (n)
  • 96.07 (a)
EIF2A 36
  • 96 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Eif2a 35
  • 89.69 (n)
  • 93.5 (a)
Eif2a 16
Eif2a 36
  • 93 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia EIF2A 36
  • 89 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia EIF2A 36
  • 87 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Eif2a 35
  • 88.74 (n)
  • 92.69 (a)
chicken
(Gallus gallus)
Aves EIF2A 35
  • 79.93 (n)
  • 84.47 (a)
EIF2A 36
  • 85 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia EIF2A 36
  • 79 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia LOC398445 35
tropical clawed frog
(Silurana tropicalis)
Amphibia eif2a 35
  • 72.46 (n)
  • 77.3 (a)
zebrafish
(Danio rerio)
Actinopterygii eif2a 35
  • 66.25 (n)
  • 70.27 (a)
eif2a 36
  • 70 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP002525 35
  • 46.12 (n)
  • 41.56 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG7414 35
  • 46.99 (n)
  • 39.89 (a)
CG7414 36
  • 35 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea E04D5.1 35
  • 49.68 (n)
  • 40.3 (a)
E04D5.1 36
  • 35 (a)
OneToOne
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AEL286C 35
  • 44.92 (n)
  • 37.22 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes -- 36
  • 26 (a)
OneToOne
-- 38
YGR054W 35
  • 43.88 (n)
  • 34.57 (a)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0A02761g 35
  • 46.33 (n)
  • 35.63 (a)
thale cress
(Arabidopsis thaliana)
eudicotyledons AT1G73180 35
  • 46.49 (n)
  • 38 (a)
bread mold
(Neurospora crassa)
Ascomycetes NCU06099 35
  • 45.38 (n)
  • 39.92 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes SPBC4B4.04 35
  • 49.17 (n)
  • 40.05 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 45 (a)
OneToOne
Species with no ortholog for EIF2A:
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for EIF2A Gene

ENSEMBL:
Gene Tree for EIF2A (if available)
TreeFam:
Gene Tree for EIF2A (if available)

Paralogs for EIF2A Gene

Selected SIMAP similar genes for EIF2A Gene using alignment to 10 proteins:

genes like me logo Genes that share paralogs with EIF2A: view

No data available for Paralogs for EIF2A Gene

Variants for EIF2A Gene

Sequence variations from dbSNP and Humsavar for EIF2A Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type MAF
rs1132979 - 150,562,658(+) TTACA(C/G)TAGTA reference, missense
rs4343650 -- 150,562,466(-) ATACC(A/T)CTTTT intron-variant
rs4681635 -- 150,550,274(+) TACGC(A/C)TTGTA intron-variant
rs4681636 -- 150,554,518(+) agctc(A/G)ttaaa intron-variant
rs5853482 -- 150,562,420(+) ATCTC(-/A)AAAAA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for EIF2A Gene

Variant ID Type Subtype PubMed ID
nsv511101 CNV Complex 20534489
nsv507130 CNV Insertion 20534489

Relevant External Links for EIF2A Gene

HapMap Linkage Disequilibrium report
EIF2A

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for EIF2A Gene

Disorders for EIF2A Gene

Relevant External Links for EIF2A

Genetic Association Database (GAD)
EIF2A
Human Genome Epidemiology (HuGE) Navigator
EIF2A
genes like me logo Genes that share disorders with EIF2A: view

No data available for UniProtKB/Swiss-Prot for EIF2A Gene

Publications for EIF2A Gene

  1. Characterization of mammalian eIF2A and identification of the yeast homolog. (PMID: 12133843) Zoll W.L. … Merrick W.C. (J. Biol. Chem. 2002) 2 3 4
  2. Mechanism and regulation of eukaryotic protein synthesis. (PMID: 1620067) Merrick W.C. (Microbiol. Rev. 1992) 2 3
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  4. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PMID: 20628086) Bailey S.D. … Anand S. (Diabetes Care 2010) 3 48
  5. Cytoskeletal scaffolding proteins interact with Lynch-Syndrome associated mismatch repair protein MLH1. (PMID: 20706999) Brieger A. … Trojan J. (Proteomics 2010) 3

Products for EIF2A Gene

Sources for EIF2A Gene

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