Aliases for EIF2A Gene
External Ids for EIF2A Gene
Previous GeneCards Identifiers for EIF2A Gene
This gene encodes a eukaryotic translation initiation factor that catalyzes the formation of puromycin-sensitive 80 S preinitiation complexes and the poly(U)-directed synthesis of polyphenylalanine at low concentrations of Mg2+. This gene should not be confused with eIF2-alpha (EIF2S1, Gene ID: 1965), the alpha subunit of the eIF2 translation initiation complex. Although both of these proteins function in binding initiator tRNA to the 40 S ribosomal subunit, the encoded protein does so in a codon-dependent manner, whereas eIF2 complex requires GTP. Alternative splicing of this gene results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jan 2016]
GeneCards Summary for EIF2A Gene
EIF2A (Eukaryotic Translation Initiation Factor 2A) is a Protein Coding gene. Among its related pathways are TGF-beta receptor signaling (Pathway Interaction Database) and Nanog in Mammalian ESC Pluripotency. Gene Ontology (GO) annotations related to this gene include translation initiation factor activity and ribosome binding.
UniProtKB/Swiss-Prot for EIF2A Gene
Functions in the early steps of protein synthesis of a small number of specific mRNAs. Acts by directing the binding of methionyl-tRNAi to 40S ribosomal subunits. In contrast to the eIF-2 complex, it binds methionyl-tRNAi to 40 S subunits in a codon-dependent manner, whereas the eIF-2 complex binds methionyl-tRNAi to 40 S subunits in a GTP-dependent manner. May act by impiging the expression of specific proteins.