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Aliases for EIF1AY Gene

Aliases for EIF1AY Gene

  • Eukaryotic Translation Initiation Factor 1A, Y-Linked 2 3 5
  • Eukaryotic Translation Initiation Factor 1A, Y Chromosome 2 3
  • Eukaryotic Translation Initiation Factor 4C 3 4
  • EIF-1A Y Isoform 3 4
  • EIF-4C 3 4

External Ids for EIF1AY Gene

Previous GeneCards Identifiers for EIF1AY Gene

  • GC0YP021892
  • GC0YP021583
  • GC0YP021584
  • GC0YP021075
  • GC0YP022737
  • GC0YP016322

Summaries for EIF1AY Gene

Entrez Gene Summary for EIF1AY Gene

  • This gene is located on the non-recombining region of the Y chromosome. It encodes a protein related to eukaryotic translation initiation factor 1A (EIF1A), which may function in stabilizing the binding of the initiator Met-tRNA to 40S ribosomal subunits. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013]

GeneCards Summary for EIF1AY Gene

EIF1AY (Eukaryotic Translation Initiation Factor 1A, Y-Linked) is a Protein Coding gene. Among its related pathways are RNA transport and Apoptotic Pathways in Synovial Fibroblasts. GO annotations related to this gene include RNA binding and translation initiation factor activity. An important paralog of this gene is EIF1AX.

UniProtKB/Swiss-Prot for EIF1AY Gene

  • Seems to be required for maximal rate of protein biosynthesis. Enhances ribosome dissociation into subunits and stabilizes the binding of the initiator Met-tRNA(I) to 40 S ribosomal subunits (By similarity).

Gene Wiki entry for EIF1AY Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for EIF1AY Gene

Genomics for EIF1AY Gene

Regulatory Elements for EIF1AY Gene

Enhancers for EIF1AY Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around EIF1AY on UCSC Golden Path with GeneCards custom track

Genomic Location for EIF1AY Gene

Chromosome:
Y
Start:
20,575,711 bp from pter
End:
20,593,154 bp from pter
Size:
17,444 bases
Orientation:
Plus strand

Genomic View for EIF1AY Gene

Genes around EIF1AY on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
EIF1AY Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for EIF1AY Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for EIF1AY Gene

Proteins for EIF1AY Gene

  • Protein details for EIF1AY Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O14602-IF1AY_HUMAN
    Recommended name:
    Eukaryotic translation initiation factor 1A, Y-chromosomal
    Protein Accession:
    O14602
    Secondary Accessions:
    • Q9BS77

    Protein attributes for EIF1AY Gene

    Size:
    144 amino acids
    Molecular mass:
    16442 Da
    Quaternary structure:
    No Data Available

neXtProt entry for EIF1AY Gene

Proteomics data for EIF1AY Gene at MOPED

Post-translational modifications for EIF1AY Gene

  • Ubiquitination at Lys 56 and Lys 88
  • Modification sites at PhosphoSitePlus

Other Protein References for EIF1AY Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for EIF1AY Gene

Domains & Families for EIF1AY Gene

Suggested Antigen Peptide Sequences for EIF1AY Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

O14602

UniProtKB/Swiss-Prot:

IF1AY_HUMAN :
  • Contains 1 S1-like domain.
  • Belongs to the eIF-1A family.
Domain:
  • Contains 1 S1-like domain.
Family:
  • Belongs to the eIF-1A family.
genes like me logo Genes that share domains with EIF1AY: view

No data available for Gene Families for EIF1AY Gene

Function for EIF1AY Gene

Molecular function for EIF1AY Gene

GENATLAS Biochemistry:
eukaryotic initiation factor 1A on chromosome Y,ubiquitous in a AZF deleted region
UniProtKB/Swiss-Prot Function:
Seems to be required for maximal rate of protein biosynthesis. Enhances ribosome dissociation into subunits and stabilizes the binding of the initiator Met-tRNA(I) to 40 S ribosomal subunits (By similarity).

Phenotypes for EIF1AY Gene

GenomeRNAi human phenotypes for EIF1AY:
genes like me logo Genes that share phenotypes with EIF1AY: view

Animal Model Products

CRISPR Products

miRNA for EIF1AY Gene

miRTarBase miRNAs that target EIF1AY

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for EIF1AY Gene

Localization for EIF1AY Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for EIF1AY Gene COMPARTMENTS Subcellular localization image for EIF1AY gene
Compartment Confidence
cytosol 3
nucleus 2
mitochondrion 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for EIF1AY Gene

Pathways & Interactions for EIF1AY Gene

genes like me logo Genes that share pathways with EIF1AY: view

Pathways by source for EIF1AY Gene

1 BioSystems pathway for EIF1AY Gene
1 KEGG pathway for EIF1AY Gene
1 Qiagen pathway for EIF1AY Gene

Gene Ontology (GO) - Biological Process for EIF1AY Gene

None

No data available for SIGNOR curated interactions for EIF1AY Gene

Drugs & Compounds for EIF1AY Gene

No Compound Related Data Available

Transcripts for EIF1AY Gene

Unigene Clusters for EIF1AY Gene

Eukaryotic translation initiation factor 1A, Y-linked:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for EIF1AY Gene

No ASD Table

Relevant External Links for EIF1AY Gene

GeneLoc Exon Structure for
EIF1AY
ECgene alternative splicing isoforms for
EIF1AY

Expression for EIF1AY Gene

mRNA expression in normal human tissues for EIF1AY Gene

mRNA differential expression in normal tissues according to GTEx for EIF1AY Gene

This gene is overexpressed in Heart - Left Ventricle (x6.5) and Heart - Atrial Appendage (x4.3).

Protein differential expression in normal tissues from HIPED for EIF1AY Gene

This gene is overexpressed in Frontal cortex (9.9), Pancreas (9.7), Blymphocyte (8.7), and CD4 Tcells (8.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for EIF1AY Gene



SOURCE GeneReport for Unigene cluster for EIF1AY Gene Hs.461178

mRNA Expression by UniProt/SwissProt for EIF1AY Gene

O14602-IF1AY_HUMAN
Tissue specificity: Ubiquitous.
genes like me logo Genes that share expression patterns with EIF1AY: view

Primer Products

In Situ Assay Products

No data available for Protein tissue co-expression partners for EIF1AY Gene

Orthologs for EIF1AY Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for EIF1AY Gene

Organism Taxonomy Gene Similarity Type Details
mouse
(Mus musculus)
Mammalia Eif1ax 35
  • 89.12 (n)
  • 99.31 (a)
Eif1ax 16
BB287469 36
  • 90 (a)
ManyToMany
Eif1a 36
  • 98 (a)
ManyToMany
Gm10264 36
  • 88 (a)
ManyToMany
Gm16368 36
  • 92 (a)
ManyToMany
Gm2016 36
  • 92 (a)
ManyToMany
Gm2035 36
  • 92 (a)
ManyToMany
Gm2046 36
  • 90 (a)
ManyToMany
Gm2056 36
  • 93 (a)
ManyToMany
Gm2075 36
  • 90 (a)
ManyToMany
Gm21319 36
  • 92 (a)
ManyToMany
Gm21936 36
  • 91 (a)
ManyToMany
Gm4027 36
  • 90 (a)
ManyToMany
Gm5039 36
  • 94 (a)
ManyToMany
Gm5662 36
  • 92 (a)
ManyToMany
Gm6803 36
  • 90 (a)
ManyToMany
Gm8300 36
  • 93 (a)
ManyToMany
Gm8332 36
  • 93 (a)
ManyToMany
chimpanzee
(Pan troglodytes)
Mammalia EIF1AY 35
  • 99.54 (n)
  • 99.31 (a)
EIF1AY 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Eif1ax 35
  • 88.66 (n)
  • 99.31 (a)
cow
(Bos Taurus)
Mammalia EIF1AY 36
  • 81 (a)
ManyToMany
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 92 (a)
ManyToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 98 (a)
OneToMany
chicken
(Gallus gallus)
Aves EIF1AY 35
  • 88.89 (n)
  • 100 (a)
EIF1AY 36
  • 100 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia EIF1AY 36
  • 100 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.29347 35
zebrafish
(Danio rerio)
Actinopterygii eif1axa 35
  • 80.15 (n)
  • 97.71 (a)
eif1axa 36
  • 96 (a)
ManyToMany
fruit fly
(Drosophila melanogaster)
Insecta eIF-1A 37
  • 81 (a)
eIF-1A 35
  • 67.94 (n)
  • 82.44 (a)
eIF-1A 36
  • 77 (a)
OneToMany
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP003119 35
  • 67.18 (n)
  • 83.21 (a)
worm
(Caenorhabditis elegans)
Secernentea H06H21.3 37
  • 65 (a)
eif-1.A 35
  • 64.58 (n)
  • 72.66 (a)
eif-1.A 36
  • 46 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes TIF11 36
  • 61 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.11104 36
  • 51 (a)
OneToMany
Species with no ortholog for EIF1AY:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for EIF1AY Gene

ENSEMBL:
Gene Tree for EIF1AY (if available)
TreeFam:
Gene Tree for EIF1AY (if available)

Paralogs for EIF1AY Gene

Paralogs for EIF1AY Gene

(1) SIMAP similar genes for EIF1AY Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with EIF1AY: view

Variants for EIF1AY Gene

Sequence variations from dbSNP and Humsavar for EIF1AY Gene

SNP ID Clin Chr 0Y pos Sequence Context AA Info Type
rs1064253 -- 20,592,684(+) TGCTG(A/G)GTTCT utr-variant-3-prime
rs1558843 -- 20,588,697(+) GCCTG(A/C)GTATT intron-variant
rs7067423 -- 20,581,711(+) AAGCT(A/G)TTATT intron-variant
rs9341308 -- 20,576,889(+) CCGAA(A/G)ACCCA intron-variant
rs9341309 -- 20,578,470(+) CCTGA(C/G)GCAGC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for EIF1AY Gene

Variant ID Type Subtype PubMed ID
nsv10025 CNV Gain 18304495

Relevant External Links for EIF1AY Gene

HapMap Linkage Disequilibrium report
EIF1AY

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for EIF1AY Gene

Disorders for EIF1AY Gene

Relevant External Links for EIF1AY

Genetic Association Database (GAD)
EIF1AY
Human Genome Epidemiology (HuGE) Navigator
EIF1AY
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
EIF1AY

No disorders were found for EIF1AY Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for EIF1AY Gene

Publications for EIF1AY Gene

  1. Functional coherence of the human Y chromosome. (PMID: 9381176) Lahn B.T. … Page D.C. (Science 1997) 2 3 4 67
  2. Quantitative Lys-I/-Gly-Gly (diGly) proteomics coupled with inducible RNAi reveals ubiquitin-mediated proteolysis of DNA damage-inducible transcript 4 (DDIT4) by the E3 ligase HUWE1. (PMID: 25147182) Thompson J.W. … Luchansky S.J. (J. Biol. Chem. 2014) 3
  3. The protein interaction landscape of the human CMGC kinase group. (PMID: 23602568) Varjosalo M. … Gstaiger M. (Cell Rep 2013) 3
  4. The interaction between eukaryotic initiation factor 1A and eIF5 retains eIF1 within scanning preinitiation complexes. (PMID: 24319994) Luna R.E. … Asano K. (Biochemistry 2013) 3
  5. HSFY genes and the P4 palindrome in the AZFb interval of the human Y chromosome are not required for spermatocyte maturation. (PMID: 22158087) Kichine E. … Mitchell M.J. (Hum. Reprod. 2012) 3

Products for EIF1AY Gene

Sources for EIF1AY Gene

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