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Aliases for EIF1AY Gene

Aliases for EIF1AY Gene

  • Eukaryotic Translation Initiation Factor 1A, Y-Linked 2 3 5
  • Eukaryotic Translation Initiation Factor 1A, Y Chromosome 2 3
  • Eukaryotic Translation Initiation Factor 4C 3 4
  • EIF-1A Y Isoform 3 4
  • EIF-4C 3 4
  • Eukaryotic Translation Initiation Factor 1A, Y-Chromosomal 3

External Ids for EIF1AY Gene

Previous GeneCards Identifiers for EIF1AY Gene

  • GC0YP021892
  • GC0YP021583
  • GC0YP021584
  • GC0YP021075
  • GC0YP022737
  • GC0YP016322

Summaries for EIF1AY Gene

Entrez Gene Summary for EIF1AY Gene

  • This gene is located on the non-recombining region of the Y chromosome. It encodes a protein related to eukaryotic translation initiation factor 1A (EIF1A), which may function in stabilizing the binding of the initiator Met-tRNA to 40S ribosomal subunits. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013]

GeneCards Summary for EIF1AY Gene

EIF1AY (Eukaryotic Translation Initiation Factor 1A, Y-Linked) is a Protein Coding gene. Among its related pathways are Apoptotic Pathways in Synovial Fibroblasts and RNA transport. GO annotations related to this gene include RNA binding and translation initiation factor activity. An important paralog of this gene is EIF1AX.

UniProtKB/Swiss-Prot for EIF1AY Gene

  • Seems to be required for maximal rate of protein biosynthesis. Enhances ribosome dissociation into subunits and stabilizes the binding of the initiator Met-tRNA(I) to 40 S ribosomal subunits (By similarity).

Gene Wiki entry for EIF1AY Gene

Additional gene information for EIF1AY Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for EIF1AY Gene

Genomics for EIF1AY Gene

Regulatory Elements for EIF1AY Gene

Enhancers for EIF1AY Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH0YH020573 0.3 FANTOM5 17.3 -2.0 -2031 0 EIF1AY KDM5DP1
GH0YH021073 0.3 FANTOM5 2.3 +498.2 498185 0 EIF1AY ENSG00000254488 TOMM22P1
GH0YH020574 0.8 ENCODE 0.7 +0.1 121 2 CTCF TBP DRAP1 MXI1 SAP130 ARID4B SIN3A DMAP1 KMT2B GATAD1 EIF1AY FAM8A9P
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around EIF1AY on UCSC Golden Path with GeneCards custom track

Genomic Location for EIF1AY Gene

Chromosome:
Y
Start:
20,575,711 bp from pter
End:
20,593,154 bp from pter
Size:
17,444 bases
Orientation:
Plus strand

Genomic View for EIF1AY Gene

Genes around EIF1AY on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
EIF1AY Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for EIF1AY Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for EIF1AY Gene

Proteins for EIF1AY Gene

  • Protein details for EIF1AY Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O14602-IF1AY_HUMAN
    Recommended name:
    Eukaryotic translation initiation factor 1A, Y-chromosomal
    Protein Accession:
    O14602
    Secondary Accessions:
    • Q9BS77

    Protein attributes for EIF1AY Gene

    Size:
    144 amino acids
    Molecular mass:
    16442 Da
    Quaternary structure:
    No Data Available

neXtProt entry for EIF1AY Gene

Post-translational modifications for EIF1AY Gene

  • Ubiquitination at posLast=5656 and isoforms=88
  • Modification sites at PhosphoSitePlus

Other Protein References for EIF1AY Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for EIF1AY Gene

Domains & Families for EIF1AY Gene

Gene Families for EIF1AY Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Suggested Antigen Peptide Sequences for EIF1AY Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

O14602

UniProtKB/Swiss-Prot:

IF1AY_HUMAN :
  • Belongs to the eIF-1A family.
Family:
  • Belongs to the eIF-1A family.
genes like me logo Genes that share domains with EIF1AY: view

Function for EIF1AY Gene

Molecular function for EIF1AY Gene

GENATLAS Biochemistry:
eukaryotic initiation factor 1A on chromosome Y,ubiquitous in a AZF deleted region
UniProtKB/Swiss-Prot Function:
Seems to be required for maximal rate of protein biosynthesis. Enhances ribosome dissociation into subunits and stabilizes the binding of the initiator Met-tRNA(I) to 40 S ribosomal subunits (By similarity).

Gene Ontology (GO) - Molecular Function for EIF1AY Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003743 translation initiation factor activity IEA --
GO:0005515 protein binding IPI 12569173
GO:0043023 ribosomal large subunit binding IEA --
genes like me logo Genes that share ontologies with EIF1AY: view

Phenotypes for EIF1AY Gene

GenomeRNAi human phenotypes for EIF1AY:
genes like me logo Genes that share phenotypes with EIF1AY: view

Animal Model Products

CRISPR Products

miRNA for EIF1AY Gene

miRTarBase miRNAs that target EIF1AY

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for EIF1AY
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for EIF1AY Gene

Localization for EIF1AY Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for EIF1AY gene
Compartment Confidence
cytosol 3
nucleus 2
mitochondrion 1

Subcellular locations from the

Human Protein Atlas (HPA)

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for EIF1AY Gene

Pathways & Interactions for EIF1AY Gene

genes like me logo Genes that share pathways with EIF1AY: view

Pathways by source for EIF1AY Gene

1 BioSystems pathway for EIF1AY Gene
1 KEGG pathway for EIF1AY Gene
1 Qiagen pathway for EIF1AY Gene

Gene Ontology (GO) - Biological Process for EIF1AY Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006412 translation IEA --
GO:0006413 translational initiation IEA --
genes like me logo Genes that share ontologies with EIF1AY: view

No data available for SIGNOR curated interactions for EIF1AY Gene

Drugs & Compounds for EIF1AY Gene

No Compound Related Data Available

Transcripts for EIF1AY Gene

Unigene Clusters for EIF1AY Gene

Eukaryotic translation initiation factor 1A, Y-linked:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for EIF1AY
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for EIF1AY Gene

No ASD Table

Relevant External Links for EIF1AY Gene

GeneLoc Exon Structure for
EIF1AY
ECgene alternative splicing isoforms for
EIF1AY

Expression for EIF1AY Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for EIF1AY Gene

mRNA differential expression in normal tissues according to GTEx for EIF1AY Gene

This gene is overexpressed in Heart - Left Ventricle (x6.5) and Heart - Atrial Appendage (x4.3).

Protein differential expression in normal tissues from HIPED for EIF1AY Gene

This gene is overexpressed in Frontal cortex (9.9), Pancreas (9.7), Blymphocyte (8.7), and CD4 Tcells (8.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for EIF1AY Gene



NURSA nuclear receptor signaling pathways regulating expression of EIF1AY Gene:

EIF1AY

SOURCE GeneReport for Unigene cluster for EIF1AY Gene:

Hs.461178

mRNA Expression by UniProt/SwissProt for EIF1AY Gene:

O14602-IF1AY_HUMAN
Tissue specificity: Ubiquitous.

Evidence on tissue expression from TISSUES for EIF1AY Gene

  • Heart(4.4)
  • Kidney(2.1)
genes like me logo Genes that share expression patterns with EIF1AY: view

Primer Products

No data available for Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for EIF1AY Gene

Orthologs for EIF1AY Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for EIF1AY Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia EIF1AY 33 34
  • 99.54 (n)
mouse
(Mus musculus)
Mammalia Eif1a 34
  • 98 (a)
ManyToMany
Gm5039 34
  • 94 (a)
ManyToMany
Gm2056 34
  • 93 (a)
ManyToMany
Gm8300 34
  • 93 (a)
ManyToMany
Gm8332 34
  • 93 (a)
ManyToMany
Gm16368 34
  • 92 (a)
ManyToMany
Gm2016 34
  • 92 (a)
ManyToMany
Gm2035 34
  • 92 (a)
ManyToMany
Gm21319 34
  • 92 (a)
ManyToMany
Gm5662 34
  • 92 (a)
ManyToMany
Gm21936 34
  • 91 (a)
ManyToMany
BB287469 34
  • 90 (a)
ManyToMany
Gm2046 34
  • 90 (a)
ManyToMany
Gm2075 34
  • 90 (a)
ManyToMany
Gm4027 34
  • 90 (a)
ManyToMany
Gm6803 34
  • 90 (a)
ManyToMany
Eif1ax 33 16
  • 89.12 (n)
Gm10264 34
  • 88 (a)
ManyToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 98 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia -- 34
  • 92 (a)
ManyToMany
rat
(Rattus norvegicus)
Mammalia Eif1ax 33
  • 88.66 (n)
cow
(Bos Taurus)
Mammalia EIF1AY 34
  • 81 (a)
ManyToMany
chicken
(Gallus gallus)
Aves EIF1AY 33 34
  • 88.89 (n)
lizard
(Anolis carolinensis)
Reptilia EIF1AY 34
  • 100 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.29347 33
zebrafish
(Danio rerio)
Actinopterygii eif1axa 33 34
  • 80.15 (n)
fruit fly
(Drosophila melanogaster)
Insecta eIF-1A 35 33 34
  • 67.94 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP003119 33
  • 67.18 (n)
worm
(Caenorhabditis elegans)
Secernentea H06H21.3 35
  • 65 (a)
eif-1.A 33 34
  • 64.58 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes TIF11 34
  • 61 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.11104 34
  • 51 (a)
OneToMany
Species where no ortholog for EIF1AY was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for EIF1AY Gene

ENSEMBL:
Gene Tree for EIF1AY (if available)
TreeFam:
Gene Tree for EIF1AY (if available)

Paralogs for EIF1AY Gene

Paralogs for EIF1AY Gene

(1) SIMAP similar genes for EIF1AY Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with EIF1AY: view

Variants for EIF1AY Gene

Sequence variations from dbSNP and Humsavar for EIF1AY Gene

SNP ID Clin Chr 0Y pos Sequence Context AA Info Type
rs1000190714 -- 20,586,834(+) ATATA(C/T)CAAAT intron-variant
rs1000556477 -- 20,581,531(+) TTCAC(C/T)ATGTT intron-variant
rs1000624790 -- 20,587,583(+) GTGCC(C/T)GGCCT intron-variant
rs1000919475 -- 20,580,345(+) TATGA(G/T)GATAA intron-variant
rs1004212641 -- 20,575,073(+) TAGCA(A/G)TTGTA upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for EIF1AY Gene

Variant ID Type Subtype PubMed ID
nsv10025 CNV gain 18304495

Relevant External Links for EIF1AY Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
EIF1AY

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for EIF1AY Gene

Disorders for EIF1AY Gene

Relevant External Links for EIF1AY

Genetic Association Database (GAD)
EIF1AY
Human Genome Epidemiology (HuGE) Navigator
EIF1AY
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
EIF1AY

No disorders were found for EIF1AY Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for EIF1AY Gene

Publications for EIF1AY Gene

  1. Functional coherence of the human Y chromosome. (PMID: 9381176) Lahn BT … Page DC (Science (New York, N.Y.) 1997) 2 3 4 60
  2. Association of Y chromosome haplotypes with autism. (PMID: 19605777) Serajee FJ … Mahbubul Huq AH (Journal of child neurology 2009) 3 45 60
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 60
  4. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 60
  5. A Global Analysis of the Receptor Tyrosine Kinase-Protein Phosphatase Interactome. (PMID: 28065597) Yao Z … Stagljar I (Molecular cell 2016) 3 60

Products for EIF1AY Gene

Sources for EIF1AY Gene

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