Aliases for EIF1AX Gene
External Ids for EIF1AX Gene
Previous HGNC Symbols for EIF1AX Gene
Previous GeneCards Identifiers for EIF1AX Gene
This gene encodes an essential eukaryotic translation initiation factor. The protein is required for the binding of the 43S complex (a 40S subunit, eIF2/GTP/Met-tRNAi and eIF3) to the 5' end of capped RNA. [provided by RefSeq, Jul 2008]
GeneCards Summary for EIF1AX Gene
EIF1AX (Eukaryotic Translation Initiation Factor 1A, X-Linked) is a Protein Coding gene. Diseases associated with EIF1AX include Differentiated Thyroid Carcinoma and Uveal Melanoma. Among its related pathways are Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S and Apoptotic Pathways in Synovial Fibroblasts. GO annotations related to this gene include poly(A) RNA binding and translation initiation factor activity. An important paralog of this gene is EIF1AY.
UniProtKB/Swiss-Prot for EIF1AX Gene
Seems to be required for maximal rate of protein biosynthesis. Enhances ribosome dissociation into subunits and stabilizes the binding of the initiator Met-tRNA(I) to 40 S ribosomal subunits.