Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 



EIF1AX Gene

protein-coding   GIFtS: 61
GCID: GC0XM020052

Eukaryotic Translation Initiation Factor 1A, X-Linked

(Previous names: eukaryotic translation initiation factor 1A, X chromosome)
(Previous symbols: EIF4C, EIF1A)
  Search for EIF1AX
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

TryGeneCards Plus

Aliases
Eukaryotic Translation Initiation Factor 1A, X-Linked1 2     EIF-1A X Isoform2 3
EIF1A1 2 3 5     EIF1AP12
EIF4C1 2 3 5     eIF-1A2
Eukaryotic Translation Initiation Factor 1A, X Chromosome1 2     Eukaryotic Translation Initiation Factor 1A, X-Chromosomal2
Eukaryotic Translation Initiation Factor 4C2 3     Putative Eukaryotic Translation Initiation Factor 1A2
eIF-4C2 3     

External Ids:    HGNC: 32501   Entrez Gene: 19642   Ensembl: ENSG000001736747   OMIM: 3001865   UniProtKB: P478133   

Export aliases for EIF1AX gene to outside databases

Previous GC identifers: GC0XU990358 GC0XM019505 GC0XM019902 GC0XM017884


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

TryGeneCards Plus

Entrez Gene summary for EIF1AX Gene:
This gene encodes an essential eukaryotic translation initiation factor. The protein is required for the binding
of the 43S complex (a 40S subunit, eIF2/GTP/Met-tRNAi and eIF3) to the 5' end of capped RNA. (provided by RefSeq,
Jul 2008)

GeneCards Summary for EIF1AX Gene:
EIF1AX (eukaryotic translation initiation factor 1A, X-linked) is a protein-coding gene. GO annotations related to this gene include translation factor activity, nucleic acid binding and translation initiation factor activity. An important paralog of this gene is EIF1AY.

UniProtKB/Swiss-Prot: IF1AX_HUMAN, P47813
Function: Seems to be required for maximal rate of protein biosynthesis. Enhances ribosome dissociation into
subunits and stabilizes the binding of the initiator Met-tRNA(I) to 40 S ribosomal subunits

Gene Wiki entry for EIF1AX Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

TryGeneCards Plus
RefSeq DNA sequence at NCBI GenBank:
NC_000023.10  NC_018934.2  NT_167197.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the EIF1AX gene promoter:
         Max1   Spz1   Pax-6   C/EBPalpha   CHOP-10   Nkx6-1   POU2F1   POU2F1a   FOXO1a   FOXO1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidEIF1AX promoter sequence
   Search Chromatin IP Primers for EIF1AX

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat EIF1AX


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: Xp22.12   Ensembl cytogenetic band:  Xp22.12   HGNC cytogenetic band: Xp22.13

EIF1AX Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
EIF1AX gene location

GeneLoc information about chromosome X         GeneLoc Exon Structure

GeneLoc location for GC0XM020052:  view genomic region     (about GC identifiers)

Start:
20,142,636 bp from pter      End:
20,159,966 bp from pter
Size:
17,331 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
About This Section

TryGeneCards Plus

UniProtKB/Swiss-Prot: IF1AX_HUMAN, P47813 (See protein sequence)
Recommended Name: Eukaryotic translation initiation factor 1A, X-chromosomal  
Size: 144 amino acids; 16460 Da
Sequence caution: Sequence=CAI40551.1; Type=Erroneous gene model prediction;
4 PDB 3D structures from and Proteopedia for EIF1AX:
1D7Q (3D)        3ZJY (3D)        4KZY (3D)        4KZZ (3D)    
Secondary accessions: B2R5U5 Q0VGC2 Q5JPS5 Q5JPS6

Explore the universe of human proteins at neXtProt for EIF1AX: NX_P47813

Explore proteomics data for EIF1AX at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys40, Lys56, Lys88, Lys94, Lys104
  • Modification sites at PhosphoSitePlus

  • See EIF1AX Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_001403.1  
    ENSEMBL proteins: 
     ENSP00000368927   ENSP00000368912  
    Reactome Protein details: P47813

    EIF1AX Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Proteins for EIF1AX
    OriGene Protein Over-expression Lysate for EIF1AX
    OriGene Custom MassSpec
    OriGene Custom Protein Services for EIF1AX
    GenScript Custom Purified and Recombinant Proteins Services for EIF1AX
    Novus Biologicals EIF1AX Proteins
    Novus Biologicals EIF1AX Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    ProSpec Recombinant Protein for EIF1AX
    Cloud-Clone Corp. Proteins for EIF1AX

     
    Search eBioscience for Proteins for EIF1AX 

    EIF1AX Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    Browse OriGene Antibodies
    OriGene Custom Antibody Services for EIF1AX
    Novus Biologicals EIF1AX Antibodies
    Abcam antibodies for EIF1AX
    Cloud-Clone Corp. Antibodies for EIF1AX
    ThermoFisher Antibodies for EIF1AX
    LSBio Antibodies in human, mouse, rat for EIF1AX

    EIF1AX Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for EIF1AX
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for EIF1AX
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for EIF1AX
    Cloud-Clone Corp. CLIAs for EIF1AX
    Search eBioscience for ELISAs for EIF1AX 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    TryGeneCards Plus
    4 InterPro protein domains:
     IPR012340 NA-bd_OB-fold
     IPR006196 RNA-binding_domain_S1_IF1
     IPR018104 TIF_eIF-1A_CS
     IPR001253 TIF_eIF-1A

    Graphical View of Domain Structure for InterPro Entry P47813

    ProtoNet protein and cluster: P47813

    1 Blocks protein domain: IPB001253 Eukaryotic initiation factor 1A (eIF-1A)

    UniProtKB/Swiss-Prot: IF1AX_HUMAN, P47813
    Similarity: Belongs to the eIF-1A family
    Similarity: Contains 1 S1-like domain


    Find genes that share domains with EIF1AX           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: IF1AX_HUMAN, P47813
    Function: Seems to be required for maximal rate of protein biosynthesis. Enhances ribosome dissociation into
    subunits and stabilizes the binding of the initiator Met-tRNA(I) to 40 S ribosomal subunits

         Genatlas biochemistry entry for EIF1AX:
    eukaryotic initiation factor 1A on chromosome X,escaping inactivation,ubiquitous

         Gene Ontology (GO): 4 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003723RNA binding ----
    GO:0003743translation initiation factor activity IEA--
    GO:0008135translation factor activity, nucleic acid binding TAS8106356
    GO:0044822poly(A) RNA binding IDA--
         
    Find genes that share ontologies with EIF1AX           About GenesLikeMe


    Phenotypes:
         3 GenomeRNAi human phenotypes for EIF1AX:
     Decreased viability  Decreased viability of wild-ty  Increased gamma-H2AX phosphory 

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for EIF1AX
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for EIF1AX

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for EIF1AX
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for EIF1AX

    miRNA
    Products:
        
    miRTarBase miRNAs that target EIF1AX:
    hsa-mir-18a-3p (MIRT040809), hsa-mir-26b-5p (MIRT029813), hsa-mir-345-5p (MIRT042730)

    Block miRNA regulation of human, mouse, rat EIF1AX using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate EIF1AX (see all 37):
    hsa-miR-124* hsa-miR-142-5p hsa-miR-4328 hsa-miR-3167 hsa-miR-374a* hsa-miR-1184 hsa-miR-29a* hsa-miR-3163
    SwitchGear 3'UTR luciferase reporter plasmidEIF1AX 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for EIF1AX
    Predesigned siRNA for gene silencing in human, mouse, rat EIF1AX

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for EIF1AX

    Clone
    Products:
         
    OriGene clones in human, mouse for EIF1AX (see all 6)
    OriGene ORF clones in mouse, rat for EIF1AX
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: EIF1AX (NM_001412)
    Sino Biological Human cDNA Clone for EIF1AX
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for EIF1AX
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat EIF1AX

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for EIF1AX
    Browse ESI BIO Cell Lines and PureStem Progenitors for EIF1AX 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for EIF1AX


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol4
    nucleus2
    extracellular1
    mitochondrion1

    Gene Ontology (GO): 1 cellular component term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005829cytosol TAS--

    Find genes that share ontologies with EIF1AX           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
    About This Section

    TryGeneCards Plus

    SuperPaths for EIF1AX About   (see all 6)  
    See pathways by source

    SuperPathContained pathways About
    1Influenza Viral RNA Transcription and Replication
    L13a-mediated translational silencing of Ceruloplasmin expression0.94
    Cap-dependent Translation Initiation0.89
    Formation of a pool of free 40S subunits0.94
    Eukaryotic Translation Initiation0.89
    GTP hydrolysis and joining of the 60S ribosomal subunit0.93
    Translation0.82
    2Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S
    Translation initiation complex formation0.91
    Formation of the ternary complex, and subsequently, the 43S complex0.91
    Ribosomal scanning and start codon recognition0.91
    Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S0.90
    3Gene Expression
    Gene Expression0.40
    4Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein
    Metabolism of proteins0.30
    5Translation Factors
    Translation Factors


    Find genes that share SuperPaths with EIF1AX           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    2 Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for EIF1AX
        eIF2 Pathway
    Insulin Receptor Pathway

    1 BioSystems Pathway for EIF1AX
        Translation Factors


    Selected Reactome Pathways for EIF1AX (see all 6)
        Formation of the ternary complex, and subsequently, the 43S complex
    L13a-mediated translational silencing of Ceruloplasmin expression
    GTP hydrolysis and joining of the 60S ribosomal subunit
    Ribosomal scanning and start codon recognition
    Formation of a pool of free 40S subunits


    1 Kegg Pathway  (Kegg details for EIF1AX):
        RNA transport

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for EIF1AX
    Interactions:

        GeneGlobe Interaction Network for EIF1AX

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for EIF1AX (P478132, 3 ENSP000003689274) via UniProtKB, MINT, STRING, and/or I2D (see all 130)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    EIF5P550102, 3, ENSP000002165544MINT-16382 MINT-16381 I2D: score=4 STRING: ENSP00000216554
    ENSG00000096150P622693I2D: score=2 
    ENSG00000223367P622693I2D: score=2 
    ENSG00000226225P622693I2D: score=2 
    ENSG00000235650P622693I2D: score=2 
    About this table

    Gene Ontology (GO): 4 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006412translation TAS--
    GO:0006413translational initiation TAS--
    GO:0010467gene expression TAS--
    GO:0044267cellular protein metabolic process TAS--

    Find genes that share ontologies with EIF1AX           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
    About This Section

    TryGeneCards Plus
    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for EIF1AX (IF1AX)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
    About This Section

    TryGeneCards Plus

    REFSEQ mRNAs for EIF1AX gene: 
    NM_001412.3  

    Unigene Cluster for EIF1AX:

    Eukaryotic translation initiation factor 1A, X-linked
    Hs.522590  [show with all ESTs]
    Unigene Representative Sequence: NM_001412
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000379607(uc004czt.3) ENST00000379593
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat EIF1AX using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate EIF1AX (see all 37):
    hsa-miR-124* hsa-miR-142-5p hsa-miR-4328 hsa-miR-3167 hsa-miR-374a* hsa-miR-1184 hsa-miR-29a* hsa-miR-3163
    SwitchGear 3'UTR luciferase reporter plasmidEIF1AX 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for EIF1AX
    Predesigned siRNA for gene silencing in human, mouse, rat EIF1AX
    Clone
    Products:
         
    OriGene clones in human, mouse for EIF1AX (see all 6)
    OriGene ORF clones in mouse, rat for EIF1AX
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: EIF1AX (NM_001412)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for EIF1AX
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat EIF1AX
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for EIF1AX
    OriGene qSTAR qPCR primer pairs in human, mouse for EIF1AX
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat EIF1AX
      QuantiTect SYBR Green Assays in human, mouse, rat EIF1AX
      QuantiFast Probe-based Assays in human, mouse, rat EIF1AX

    Additional mRNA sequence: 

    AK312320.1 AL079283.1 AL832930.1 BC000793.1 BC047573.1 BC067851.1 BC110421.1 BT007064.1 
    L18960.1 

    17 DOTS entries:

    DT.419086  DT.91770289  DT.100886803  DT.97847960  DT.100029862  DT.100886800  DT.121315923  DT.121315926 
    DT.121409780  DT.95352676  DT.95352677  DT.95352694  DT.100886802  DT.101978531  DT.121315864  DT.121315927 
    DT.95092784 

    Selected AceView cDNA sequences (see all 546):

    AA029033 AI739302 BP355479 BM661824 BM975264 BG142253 CR610950 AI271801 
    AI523253 BM720759 CB121019 BX280453 BF529731 AW841345 AA098967 AW603333 
    AI346296 BQ436116 CD677690 AI351670 AI090044 AA744861 CD368260 CA312695 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TryGeneCards Plus

    EIF1AX expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: ACAGCTAATT
    EIF1AX Expression
    About this image

    EIF1AX Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    EIF1AX Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.522590
        Custom PCR Arrays for EIF1AX
    Primer
    Products:
    OriGene qPCR primer pairs and template standards for EIF1AX
    OriGene qSTAR qPCR primer pairs in human, mouse for EIF1AX
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat EIF1AX
    QuantiTect SYBR Green Assays in human, mouse, rat EIF1AX
    QuantiFast Probe-based Assays in human, mouse, rat EIF1AX
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for EIF1AX

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    TryGeneCards Plus

    This gene was present in the common ancestor of eukaryotes.

    Orthologs for EIF1AX gene from Selected species (see all 27)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Eif1a1 , 5 eukaryotic translation initiation factor 1A1, 5 87.73(n)1
    98.61(a)1
      18 (24.68 cM)5
    136641  NM_010120.51  NP_034250.31 
     465977045 
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.248112 Xenopus laevis transcribed sequence with strong similarity more 85.56(n)    CA983472.1 
    zebrafish
    (Danio rerio)
    Actinopterygii Dr.150022 Transcribed sequence with strong similarity to protein more 80.91(n)    BM534055.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta eIF-1A6
    Eukaryotic initiation factor 1A
    78(a)
    1 → many
    3R(14100387-14108206)
    worm
    (Caenorhabditis elegans)
    Secernentea eif-1.A6
    Protein EIF-1.A (eif-1.A) mRNA, complete cds
    46(a)
    1 → many
    IV(4810934-4811981) WBGene00019162
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes TIF11(YMR260C)4
    TIF111
    Translation initiation factor eIF1A, essential protein more4
    TIF111
    65.14(n)1
    65.65(a)1
      13(789839-789378)4
    8553021, 4  NP_013987.11, 4 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons AT2G045201 AT2G04520 65.9(n)
    74.81(a)
      814994  NM_126483.3  NP_178531.1 
    rice
    (Oryza sativa)
    Liliopsida Os.47112 Oryza sativa (japonica cultivar-group) mRNA for eukaryotic more 77.9(n)    AK120036.1 


    ENSEMBL Gene Tree for EIF1AX (if available)
    TreeFam Gene Tree for EIF1AX (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

    TryGeneCards Plus
    Paralogs for EIF1AX gene
    EIF1AY2  
    1 SIMAP similar gene for EIF1AX using alignment to 2 protein entries:     IF1AX_HUMAN (see all proteins):
    EIF1AY

    Find genes that share paralogs with EIF1AX           About GenesLikeMe


    1 Pseudogenes.org Pseudogene for EIF1AX
    PGOHUM00000247832


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

    TryGeneCards Plus

    Selected SNPs for EIF1AX (see all 202)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr X posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1875072341,2
    --20142221(+) GAACTA/GAACAA 1 -- ds50010--------
    rs1924275281,2
    --20142286(+) CCAGAA/GGTGTA 1 -- ds50010--------
    rs1485814391,2
    C--20142323(+) GCATCA/GTATAA 1 -- ds50010--------
    rs1429566701,2
    C--20142419(+) GATTTA/GTGACA 1 -- ds50010--------
    rs1841564321,2
    --20142421(+) TTTGTA/GACAAA 1 -- ds50010--------
    rs1509373031,2
    C--20142508(+) AGACAA/GAAATA 1 -- ds50010--------
    rs1875026001,2
    --20142519(+) AAAACA/CAGGTA 1 -- ds50010--------
    rs59558841,2
    C,F--20142560(+) TTAAAA/TACAGC 1 -- ds50011Minor allele frequency- T:0.00NA 2
    rs2000428381,2
    C--20142590(+) ATATG-/AATA  
            
    AATAG
    1 -- ds50010--------
    rs1927408311,2
    --20142630(+) AATCAA/GTTGTA 1 -- ds50010--------

    HapMap Linkage Disequilibrium report for EIF1AX (20142636 - 20159966 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for EIF1AX:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv820390CNV Duplication20802225
    esv25136CNV Gain+Loss19812545

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing EIF1AX
    DNA2.0 Custom Variant and Variant Library Synthesis for EIF1AX

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    TryGeneCards Plus
    OMIM gene information: 300186    OMIM disorders: --


    Find genes that share disorders with EIF1AX           About GenesLikeMe


    Export disorders for EIF1AX gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    TryGeneCards Plus

    PubMed articles for EIF1AX gene, integrated from 10 sources (see all 38):
    (articles sorted by number of sources associating them with EIF1AX)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Determination of the amino acid sequence of rabbit, human, and wheat germ protein synthesis factor eIF-4C by cloning and chemical sequencing. (PubMed id 8106356)1, 2, 3 Dever T.E....Hershey J.W.B. (J. Biol. Chem. 1994)
    2. The DNA sequence of the human X chromosome. (PubMed id 15772651)1, 2 Ross M.T.... Bentley D.R. (Nature 2005)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    4. The eIF1A solution structure reveals a large RNA-binding surface important for scanning function. (PubMed id 10678173)1, 2 Battiste J.L.... Wagner G. (Mol. Cell 2000)
    5. Functional coherence of the human Y chromosome. (PubMed id 9381176)1, 3 Lahn B.T. and Page D.C. (Science 1997)
    6. Domains of eIF1A that mediate binding to eIF2, eIF3 and eIF5B and promote ternary complex recruitment in vivo. (PubMed id 12514125)1, 9 Olsen D.S....Hinnebusch A.G. (EMBO J. 2003)
    7. Importin 13: a novel mediator of nuclear import and export. (PubMed id 11447110)1, 9 Mingot J.-M.... Goerlich D. (EMBO J. 2001)
    8. Exome sequencing identifies recurrent somatic mutations in EIF1AX and SF3B1 in uveal melanoma with disomy 3. (PubMed id 23793026)1 Martin M....Zeschnigk M. (Nat. Genet. 2013)
    9. Coordinated movements of eukaryotic translation initiation factors eIF1, eIF1A, and eIF5 trigger phosphate release from eIF2 in response to start codon recognition by the ribosomal preinitiation complex. (PubMed id 23293029)1 Nanda J.S....Lorsch J.R. (J. Biol. Chem. 2013)
    10. Pathway Analysis of ChIP-Seq-Based NRF1 Target Genes Suggests a Logical Hypothesis of their Involvement in the Pathogenesis of Neurodegenerative Diseases. (PubMed id 24250222)1 Satoh J....Yamamoto Y. (Gene Regul Syst Bio 2013)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

    TryGeneCards Plus
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

    TryGeneCards Plus
    Entrez Gene: 1964 HGNC: 3250 AceView: EIF1AX Ensembl:ENSG00000173674 euGenes: HUgn1964
    ECgene: EIF1AX Kegg: 1964 H-InvDB: EIF1AX

    (According to HUGE)
    About This Section

    TryGeneCards Plus
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

    TryGeneCards Plus
    NameDescription
    PharmGKB entry for EIF1AX Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for EIF1AX Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

    TryGeneCards Plus
    Patent Information for EIF1AX gene:
    Search GeneIP for patents involving EIF1AX

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

    TryGeneCards Plus

     
     EMD Millipore genomic analysis products

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Enzyme Activity Assays/Reagents  
     Browse ELISpot/FluoroSpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Luminex Assays  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Recombinant/Natural Proteins   Browse Stem Cell Products  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     Browse OriGene Antibodies   OriGene RNAi products in human, mouse, rat for EIF1AX  
     OriGene qPCR primer pairs and template standards for EIF1AX   OriGene Protein Over-expression Lysate for EIF1AX  
     OriGene Custom Mass Spec   OriGene clones in human, mouse for EIF1AX  
     OriGene qSTAR qPCR primer pairs in human, mouse for EIF1AX   OriGene Purified Protein for EIF1AX  
     OriGene ORF clones in mouse, rat for EIF1AX   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for EIF1AX   OriGene Custom Protein Services for EIF1AX  

     
     
     Block miRNA regulation of human, mouse, rat EIF1AX using miScript Target Protectors SeqTarget long-range PCR primers for resequencing EIF1AX
     DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat EIF1AX Predesigned siRNA for gene silencing in human, mouse, rat EIF1AX
     QuantiFast Probe-based Assays in human, mouse, rat EIF1AX QuantiTect SYBR Green Assays in human, mouse, rat EIF1AX
     Custom PCR Arrays for EIF1AX Search Chromatin IP Primers for EIF1AX
     Pre-validated RT2 qPCR Primer Assay in human, mouse, rat EIF1AX  GeneGlobe Interaction Network for EIF1AX
     Regulatory tfbs in EIF1AX promoter
     GenScript Custom Purified and Recombinant Proteins Services for EIF1AX GenScript cDNA clones with any tag delivered in your preferred vector for EIF1AX
     GenScript Custom Assay Services for EIF1AX GenScript Custom overexpressing Cell Line Services for EIF1AX
     CloneReady with Over 120,000 Genes  Gene Synthesis: Any Gene in Any Vector
     Vector-based siRNA and miRNA, Ready for Transfection Gene Mutant Library, Variants up to 10^11
     Plasmid Preparation Custom Peptide Services
     Search for Antibodies & Assays

     Search Tocris compounds for EIF1AX (IF1AX)
     Browse Sino Biological Proteins
     Browse Sino Biological Cell Lysates
     cDNA Clones for EIF1AX
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

     Novus Tissue Slides
     EIF1AX antibodies
     EIF1AX proteins
     EIF1AX lysates
     Antibodies for EIF1AX
     See all of Abcam's Antibodies, Kits and Proteins for EIF1AX
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Recombinant Protein for EIF1AX
     Proteins for EIF1AX
     Antibodies for EIF1AX
     ELISAs for EIF1AX
     CLIAs for EIF1AX



     Browse ESI BIO Cell Lines and PureStem Progenitors for EIF1AX
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for EIF1AX
     SwitchGear 3'UTR luciferase reporter plasmids for EIF1AX
     SwitchGear Promoter luciferase reporter plasmids for EIF1AX
     ThermoFisher Antibodies for EIF1AX
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat EIF1AX
     inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for EIF1AX
     inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for EIF1AX
     LSBio Antibodies in human, mouse, rat for EIF1AX
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
     Browse compounds at ApexBio
     Search Addgene for plasmids for EIF1AX
      Search eBioscience for proteins for EIF1AX
      Search eBioscience for elisas for EIF1AX
      eBioscience FlowRNA Probe Sets
           
    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014 , 21 Aug 2014 , 8 Sep 2014

    View Random Gene

    Category
    (GIFtS: )
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      EIF1AX gene at Home site.
    Version: 3.12.212 17 Sep 2014
    hostname: 356977-web1.xennexinc.com index build: 128 solr: 1.4