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Aliases for EIF1AX Gene

Aliases for EIF1AX Gene

  • Eukaryotic Translation Initiation Factor 1A, X-Linked 2 3 5
  • Eukaryotic Translation Initiation Factor 1A, X Chromosome 2 3
  • Eukaryotic Translation Initiation Factor 4C 3 4
  • EIF-1A X Isoform 3 4
  • EIF-4C 3 4
  • EIF1A 3 4
  • EIF4C 3 4
  • Eukaryotic Translation Initiation Factor 1A, X-Chromosomal 3
  • Putative Eukaryotic Translation Initiation Factor 1A 3
  • EIF1AP1 3
  • EIF-1A 3

External Ids for EIF1AX Gene

Previous HGNC Symbols for EIF1AX Gene

  • EIF4C
  • EIF1A

Previous GeneCards Identifiers for EIF1AX Gene

  • GC0XU990358
  • GC0XM019505
  • GC0XM019902
  • GC0XM017884

Summaries for EIF1AX Gene

Entrez Gene Summary for EIF1AX Gene

  • This gene encodes an essential eukaryotic translation initiation factor. The protein is required for the binding of the 43S complex (a 40S subunit, eIF2/GTP/Met-tRNAi and eIF3) to the 5' end of capped RNA. [provided by RefSeq, Jul 2008]

GeneCards Summary for EIF1AX Gene

EIF1AX (Eukaryotic Translation Initiation Factor 1A, X-Linked) is a Protein Coding gene. Diseases associated with EIF1AX include Differentiated Thyroid Carcinoma and Uveal Melanoma. Among its related pathways are Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S and Apoptotic Pathways in Synovial Fibroblasts. GO annotations related to this gene include poly(A) RNA binding and translation initiation factor activity. An important paralog of this gene is EIF1AY.

UniProtKB/Swiss-Prot for EIF1AX Gene

  • Seems to be required for maximal rate of protein biosynthesis. Enhances ribosome dissociation into subunits and stabilizes the binding of the initiator Met-tRNA(I) to 40 S ribosomal subunits.

Gene Wiki entry for EIF1AX Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for EIF1AX Gene

Genomics for EIF1AX Gene

Regulatory Elements for EIF1AX Gene

Enhancers for EIF1AX Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH0XF019839 1.4 FANTOM5 Ensembl ENCODE 4.4 +300.7 300748 3.8 HDGF PKNOX1 WRNIP1 TEAD4 BMI1 EBF1 POLR2A SCRT2 PRDM10 ETV6 CXorf23 EIF1AX SH3KBP1 GC0XP019714
GH0XF020251 1.1 Ensembl ENCODE 4.2 -111.0 -111024 1.9 ELF3 CBX3 ZFP64 THRB RAD21 RARA KAT2B GATA4 ZNF143 FOS CXorf23 EIF1AX RPS6KA3
GH0XF020139 1 ENCODE 0.8 +0.2 150 4.1 HDGF PKNOX1 ATF1 WRNIP1 ZNF133 ARID4B SIN3A FEZF1 DMAP1 ZNF2 CXorf23 EIF1AX EIF1AX-AS1
GH0XF020309 0.2 ENCODE 4 -168.1 -168111 0.9 CXorf23 EIF1AX ENSG00000283631 RPS6KA3
GH0XF019487 0.2 ENCODE 3.7 +654.2 654153 0.7 EIF1AX EIF5P2 GC0XM019413
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around EIF1AX on UCSC Golden Path with GeneCards custom track

Promoters for EIF1AX Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001488789 448 2801 HDGF PKNOX1 ATF1 WRNIP1 ZNF133 ARID4B SIN3A FEZF1 DMAP1 ZNF2

Genomic Location for EIF1AX Gene

Chromosome:
X
Start:
20,124,518 bp from pter
End:
20,141,848 bp from pter
Size:
17,331 bases
Orientation:
Minus strand

Genomic View for EIF1AX Gene

Genes around EIF1AX on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
EIF1AX Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for EIF1AX Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for EIF1AX Gene

Proteins for EIF1AX Gene

  • Protein details for EIF1AX Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P47813-IF1AX_HUMAN
    Recommended name:
    Eukaryotic translation initiation factor 1A, X-chromosomal
    Protein Accession:
    P47813
    Secondary Accessions:
    • B2R5U5
    • Q0VGC2
    • Q5JPS5
    • Q5JPS6

    Protein attributes for EIF1AX Gene

    Size:
    144 amino acids
    Molecular mass:
    16460 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=CAI40551.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for EIF1AX Gene

neXtProt entry for EIF1AX Gene

Post-translational modifications for EIF1AX Gene

  • Ubiquitination at Lys 56
  • Modification sites at PhosphoSitePlus

Other Protein References for EIF1AX Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for EIF1AX Gene

Domains & Families for EIF1AX Gene

Suggested Antigen Peptide Sequences for EIF1AX Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P47813

UniProtKB/Swiss-Prot:

IF1AX_HUMAN :
  • Contains 1 S1-like domain.
  • Belongs to the eIF-1A family.
Domain:
  • Contains 1 S1-like domain.
Family:
  • Belongs to the eIF-1A family.
genes like me logo Genes that share domains with EIF1AX: view

No data available for Gene Families for EIF1AX Gene

Function for EIF1AX Gene

Molecular function for EIF1AX Gene

GENATLAS Biochemistry:
eukaryotic initiation factor 1A on chromosome X,escaping inactivation,ubiquitous
UniProtKB/Swiss-Prot Function:
Seems to be required for maximal rate of protein biosynthesis. Enhances ribosome dissociation into subunits and stabilizes the binding of the initiator Met-tRNA(I) to 40 S ribosomal subunits.

Gene Ontology (GO) - Molecular Function for EIF1AX Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003743 translation initiation factor activity IEA --
GO:0005515 protein binding IPI 21139563
GO:0008135 translation factor activity, RNA binding TAS 8106356
GO:0044822 poly(A) RNA binding IDA 22658674
genes like me logo Genes that share ontologies with EIF1AX: view
genes like me logo Genes that share phenotypes with EIF1AX: view

Human Phenotype Ontology for EIF1AX Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Model Products

miRNA for EIF1AX Gene

miRTarBase miRNAs that target EIF1AX

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targets and HOMER Transcription for EIF1AX Gene

Localization for EIF1AX Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for EIF1AX gene
Compartment Confidence
cytosol 5
nucleus 2
extracellular 1
mitochondrion 1

Gene Ontology (GO) - Cellular Components for EIF1AX Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with EIF1AX: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for EIF1AX Gene

Pathways & Interactions for EIF1AX Gene

genes like me logo Genes that share pathways with EIF1AX: view

Gene Ontology (GO) - Biological Process for EIF1AX Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006412 translation IEA --
GO:0006413 translational initiation IEA,TAS --
genes like me logo Genes that share ontologies with EIF1AX: view

No data available for SIGNOR curated interactions for EIF1AX Gene

Transcripts for EIF1AX Gene

mRNA/cDNA for EIF1AX Gene

Unigene Clusters for EIF1AX Gene

Eukaryotic translation initiation factor 1A, X-linked:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for EIF1AX Gene

No ASD Table

Relevant External Links for EIF1AX Gene

GeneLoc Exon Structure for
EIF1AX
ECgene alternative splicing isoforms for
EIF1AX

Expression for EIF1AX Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for EIF1AX Gene

Protein differential expression in normal tissues from HIPED for EIF1AX Gene

This gene is overexpressed in Islet of Langerhans (9.1) and Pancreas (6.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for EIF1AX Gene



Protein tissue co-expression partners for EIF1AX Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of EIF1AX Gene:

EIF1AX

SOURCE GeneReport for Unigene cluster for EIF1AX Gene:

Hs.522590
genes like me logo Genes that share expression patterns with EIF1AX: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for EIF1AX Gene

Orthologs for EIF1AX Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for EIF1AX Gene

Organism Taxonomy Gene Similarity Type Details
dog
(Canis familiaris)
Mammalia EIF1AX 35
  • 100 (a)
OneToOne
LOC611715 34
  • 94.21 (n)
oppossum
(Monodelphis domestica)
Mammalia EIF1AX 35
  • 100 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Eif1ax 35
  • 100 (a)
OneToOne
Eif1a 34 16
  • 87.73 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 99 (a)
OneToMany
chimpanzee
(Pan troglodytes)
Mammalia -- 35
  • 99 (a)
ManyToMany
cow
(Bos Taurus)
Mammalia EIF1AX 34 35
  • 90.74 (n)
rat
(Rattus norvegicus)
Mammalia Eif1a 34
  • 85.5 (n)
tropical clawed frog
(Silurana tropicalis)
Amphibia eif1ax 34
  • 86.81 (n)
Str.7119 34
African clawed frog
(Xenopus laevis)
Amphibia Xl.24811 34
zebrafish
(Danio rerio)
Actinopterygii eif1axb 34 35
  • 81.48 (n)
Dr.15002 34
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.679 34
fruit fly
(Drosophila melanogaster)
Insecta eIF-1A 35
  • 78 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea eif-1.A 35
  • 46 (a)
OneToMany
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0E11287g 34
  • 66.16 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes TIF11 34 35 37
  • 65.14 (n)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AER275C 34
  • 61.32 (n)
thale cress
(Arabidopsis thaliana)
eudicotyledons AT2G04520 34
  • 65.9 (n)
soybean
(Glycine max)
eudicotyledons Gma.5683 34
Alicante grape
(Vitis vinifera)
eudicotyledons Vvi.8105 34
rice
(Oryza sativa)
Liliopsida Os06g0342200 34
  • 63.61 (n)
Os.4711 34
barley
(Hordeum vulgare)
Liliopsida Hv.12801 34
wheat
(Triticum aestivum)
Liliopsida Ta.14227 34
corn
(Zea mays)
Liliopsida Zm.16531 34
bread mold
(Neurospora crassa)
Ascomycetes NCU07437 34
  • 67.94 (n)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes tif11 34
  • 67.18 (n)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.11104 35
  • 52 (a)
OneToMany
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.10045 34
Species where no ortholog for EIF1AX was found in the sources mined by GeneCards:
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • beta proteobacteria (Neisseria meningitidis)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)

Evolution for EIF1AX Gene

ENSEMBL:
Gene Tree for EIF1AX (if available)
TreeFam:
Gene Tree for EIF1AX (if available)

Paralogs for EIF1AX Gene

Paralogs for EIF1AX Gene

(1) SIMAP similar genes for EIF1AX Gene using alignment to 2 proteins:

Pseudogenes.org Pseudogenes for EIF1AX Gene

genes like me logo Genes that share paralogs with EIF1AX: view

Variants for EIF1AX Gene

Sequence variations from dbSNP and Humsavar for EIF1AX Gene

SNP ID Clin Chr 0X pos Sequence Context AA Info Type
rs10284116 -- 20,140,695(+) ACTTA(C/T)GGACT intron-variant, downstream-variant-500B
rs1043014 -- 20,126,287(-) TTCTT(C/T)TACTA utr-variant-3-prime
rs111358705 -- 20,134,160(+) GGTGG(A/G)CGGAT intron-variant
rs111831757 -- 20,143,126(+) TTCAC(G/T)TTCTA upstream-variant-2KB
rs111992396 -- 20,129,040(+) AAGAA(C/G/T)AGAAT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for EIF1AX Gene

Variant ID Type Subtype PubMed ID
nsv820390 CNV duplication 20802225
esv25136 CNV gain+loss 19812545

Variation tolerance for EIF1AX Gene

Residual Variation Intolerance Score: 45.3% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for EIF1AX Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
EIF1AX

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for EIF1AX Gene

Disorders for EIF1AX Gene

MalaCards: The human disease database

(2) MalaCards diseases for EIF1AX Gene - From: Orphanet, DISEASES, and GeneCards

Disorder Aliases PubMed IDs
differentiated thyroid carcinoma
  • papillary or follicular thyroid carcinoma
uveal melanoma
  • melanoma of uvea
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for EIF1AX

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
EIF1AX
genes like me logo Genes that share disorders with EIF1AX: view

No data available for UniProtKB/Swiss-Prot and Genatlas for EIF1AX Gene

Publications for EIF1AX Gene

  1. Determination of the amino acid sequence of rabbit, human, and wheat germ protein synthesis factor eIF-4C by cloning and chemical sequencing. (PMID: 8106356) Dever T.E. … Hershey J.W.B. (J. Biol. Chem. 1994) 2 3 4 64
  2. The DNA sequence of the human X chromosome. (PMID: 15772651) Ross M.T. … Bentley D.R. (Nature 2005) 3 4 64
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  4. Domains of eIF1A that mediate binding to eIF2, eIF3 and eIF5B and promote ternary complex recruitment in vivo. (PMID: 12514125) Olsen D.S. … Hinnebusch A.G. (EMBO J. 2003) 3 22 64
  5. Importin 13: a novel mediator of nuclear import and export. (PMID: 11447110) Mingot J.-M. … Goerlich D. (EMBO J. 2001) 3 22 64

Products for EIF1AX Gene

Sources for EIF1AX Gene

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