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Aliases for EIF1AD Gene

Aliases for EIF1AD Gene

  • Eukaryotic Translation Initiation Factor 1A Domain Containing 2 3 5
  • Eukaryotic Translation Initiation Factor 1A Domain-Containing Protein 3 4
  • Haponin 3 4
  • Probable RNA-Binding Protein EIF1AD 3

External Ids for EIF1AD Gene

Previous GeneCards Identifiers for EIF1AD Gene

  • GC11M065522
  • GC11M065764
  • GC11M062090

Summaries for EIF1AD Gene

GeneCards Summary for EIF1AD Gene

EIF1AD (Eukaryotic Translation Initiation Factor 1A Domain Containing) is a Protein Coding gene. GO annotations related to this gene include RNA binding and translation initiation factor activity.

UniProtKB/Swiss-Prot for EIF1AD Gene

  • Plays a role into cellular response to oxidative stress. Decreases cell proliferation.

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for EIF1AD Gene

Genomics for EIF1AD Gene

Regulatory Elements for EIF1AD Gene

Enhancers for EIF1AD Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH11G065470 2.7 VISTA FANTOM5 Ensembl ENCODE dbSUPER 39.5 +512.1 512093 40.0 MLX CREB3L1 AGO1 ZFP64 FEZF1 DMAP1 YBX1 YY1 SLC30A9 ZNF143 LOC105369352 ZFPL1 KAT5 ENSG00000254461 EIF1AD NEAT1 FRMD8 EHBP1L1 POLA2 LOC101927789
GH11G065414 2.2 FANTOM5 Ensembl ENCODE dbSUPER 31.8 +578.0 577995 18.8 MLX CREB3L1 AGO1 ZFP64 FEZF1 DMAP1 YBX1 YY1 SLC30A9 ZNF143 ZFPL1 NEAT1 LOC105369352 KAT5 EIF1AD FRMD8 MUS81 PCNX3 POLA2 ENSG00000255320
GH11G065650 2.1 FANTOM5 Ensembl ENCODE dbSUPER 28.8 +349.5 349465 5.4 CREB3L1 MLX AGO1 ZFP64 DMAP1 FEZF1 YY1 SLC30A9 ZNF143 ZNF263 EIF1AD MAP3K11 ZFPL1 SIPA1 RNASEH2C LOC105369352 MRPL11 RBM14 KAT5 PCNX3
GH11G066078 1.9 FANTOM5 Ensembl ENCODE dbSUPER 30.2 -79.6 -79634 7.5 HDGF PKNOX1 FOXA2 AGO1 SIN3A YBX1 FEZF1 ZNF121 GATA2 CBX5 EIF1AD ENSG00000255320 SF3B2 SIPA1 RBM14 PACS1 ENSG00000258297 ZFPL1 PCNX3 KAT5
GH11G066342 1.8 FANTOM5 ENCODE dbSUPER 29.8 -346.4 -346369 11.8 MLX CREB3L1 ZFP64 DMAP1 YY1 SLC30A9 ZNF143 SP3 NFYC TBX21 RIN1 EIF1AD ENSG00000258297 ACTN3 RAD9A RBM14 KAT5 ENSG00000255320 LOC105369352 CTSF
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around EIF1AD on UCSC Golden Path with GeneCards custom track

Promoters for EIF1AD Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000040919 176 2401 CREB3L1 ZFP64 FEZF1 DMAP1 YY1 SLC30A9 ZNF143 ZNF263 SP3 TBX21

Genomic Location for EIF1AD Gene

Chromosome:
11
Start:
65,996,545 bp from pter
End:
66,002,176 bp from pter
Size:
5,632 bases
Orientation:
Minus strand

Genomic View for EIF1AD Gene

Genes around EIF1AD on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
EIF1AD Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for EIF1AD Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for EIF1AD Gene

Proteins for EIF1AD Gene

  • Protein details for EIF1AD Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8N9N8-EIF1A_HUMAN
    Recommended name:
    Probable RNA-binding protein EIF1AD
    Protein Accession:
    Q8N9N8
    Secondary Accessions:
    • B2R4N5
    • Q9BSC1

    Protein attributes for EIF1AD Gene

    Size:
    165 amino acids
    Molecular mass:
    19053 Da
    Quaternary structure:
    • Interacts with GAPDH and STAT1.

    Three dimensional structures from OCA and Proteopedia for EIF1AD Gene

neXtProt entry for EIF1AD Gene

Post-translational modifications for EIF1AD Gene

  • Ubiquitination at isoforms=56, Lys98, and Lys112
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for EIF1AD Gene

Domains & Families for EIF1AD Gene

Suggested Antigen Peptide Sequences for EIF1AD Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8N9N8

UniProtKB/Swiss-Prot:

EIF1A_HUMAN :
  • Belongs to the EIF1AD family.
Family:
  • Belongs to the EIF1AD family.
genes like me logo Genes that share domains with EIF1AD: view

No data available for Gene Families for EIF1AD Gene

Function for EIF1AD Gene

Molecular function for EIF1AD Gene

UniProtKB/Swiss-Prot Function:
Plays a role into cellular response to oxidative stress. Decreases cell proliferation.

Gene Ontology (GO) - Molecular Function for EIF1AD Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003743 translation initiation factor activity IEA --
GO:0005515 protein binding IPI 16189514
genes like me logo Genes that share ontologies with EIF1AD: view
genes like me logo Genes that share phenotypes with EIF1AD: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for EIF1AD Gene

Localization for EIF1AD Gene

Subcellular locations from UniProtKB/Swiss-Prot for EIF1AD Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for EIF1AD gene
Compartment Confidence
nucleus 5
cytoskeleton 2
cytosol 2
mitochondrion 1

Gene Ontology (GO) - Cellular Components for EIF1AD Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IBA,IEA --
genes like me logo Genes that share ontologies with EIF1AD: view

Pathways & Interactions for EIF1AD Gene

SuperPathways for EIF1AD Gene

No Data Available

Gene Ontology (GO) - Biological Process for EIF1AD Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006413 translational initiation IEA --
genes like me logo Genes that share ontologies with EIF1AD: view

No data available for Pathways by source and SIGNOR curated interactions for EIF1AD Gene

Drugs & Compounds for EIF1AD Gene

No Compound Related Data Available

Transcripts for EIF1AD Gene

Unigene Clusters for EIF1AD Gene

Eukaryotic translation initiation factor 1A domain containing:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for EIF1AD Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b · 3c ^ 4 ^ 5a · 5b ^ 6 ^ 7a · 7b
SP1: -
SP2: - -
SP3: - -
SP4: - - - -
SP5:

Relevant External Links for EIF1AD Gene

GeneLoc Exon Structure for
EIF1AD
ECgene alternative splicing isoforms for
EIF1AD

Expression for EIF1AD Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for EIF1AD Gene

Protein differential expression in normal tissues from HIPED for EIF1AD Gene

This gene is overexpressed in Peripheral blood mononuclear cells (12.5), Breast (11.1), Lung (9.7), CD8 Tcells (6.9), and Pancreas (6.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for EIF1AD Gene



Protein tissue co-expression partners for EIF1AD Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of EIF1AD Gene:

EIF1AD

SOURCE GeneReport for Unigene cluster for EIF1AD Gene:

Hs.425178

mRNA Expression by UniProt/SwissProt for EIF1AD Gene:

Q8N9N8-EIF1A_HUMAN
Tissue specificity: Expressed in the glioblastoma cell line U-87MG, the embryonic kidney cell line HEK293, the pancreatic carcinoma cell line PANC-1, the breast carcinoma cell line MCF-7, the lung cancer cell line NCI-H460, and the chronic myelogenous leukemia cell line K-562.

Evidence on tissue expression from TISSUES for EIF1AD Gene

  • Muscle(4.2)
  • Skin(4.2)
genes like me logo Genes that share expression patterns with EIF1AD: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for EIF1AD Gene

Orthologs for EIF1AD Gene

This gene was present in the common ancestor of animals.

Orthologs for EIF1AD Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia EIF1AD 34 35
  • 99.8 (n)
dog
(Canis familiaris)
Mammalia EIF1AD 34 35
  • 92.32 (n)
cow
(Bos Taurus)
Mammalia EIF1AD 34 35
  • 91.92 (n)
oppossum
(Monodelphis domestica)
Mammalia -- 35
  • 90 (a)
OneToMany
-- 35
  • 88 (a)
OneToMany
mouse
(Mus musculus)
Mammalia Eif1ad 34 16 35
  • 88.24 (n)
rat
(Rattus norvegicus)
Mammalia Eif1ad 34
  • 87.36 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia EIF1AD 35
  • 73 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia eif1ad 34
  • 66.45 (n)
zebrafish
(Danio rerio)
Actinopterygii eif1ad 34 35
  • 59.91 (n)
-- 34
fruit fly
(Drosophila melanogaster)
Insecta CG31957 34 35
  • 59.06 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP010181 34
  • 58.85 (n)
worm
(Caenorhabditis elegans)
Secernentea ZK856.11 34 35
  • 47.38 (n)
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 41 (a)
OneToOne
Species where no ortholog for EIF1AD was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for EIF1AD Gene

ENSEMBL:
Gene Tree for EIF1AD (if available)
TreeFam:
Gene Tree for EIF1AD (if available)

Paralogs for EIF1AD Gene

No data available for Paralogs for EIF1AD Gene

Variants for EIF1AD Gene

Sequence variations from dbSNP and Humsavar for EIF1AD Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type
rs387906871 Pathogenic 66,003,284(+) TCGTG(A/G)CAGAG upstream-variant-2KB, reference, missense
rs78790365 Likely benign 66,002,276(+) AGGAA(G/T)TCCTC upstream-variant-2KB, utr-variant-5-prime
rs117774800 Uncertain significance 66,002,122(+) TGCGA(C/T)GTGAG upstream-variant-2KB, utr-variant-5-prime
rs141605220 Uncertain significance 66,002,233(+) GTCAA(A/G)CCTAA upstream-variant-2KB, utr-variant-5-prime
rs142270527 Uncertain significance 66,004,045(+) ACCCC(C/G)ACCCT upstream-variant-2KB, utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for EIF1AD Gene

Variant ID Type Subtype PubMed ID
nsv819658 CNV loss 19587683
nsv832191 CNV loss 17160897

Variation tolerance for EIF1AD Gene

Residual Variation Intolerance Score: 54.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.40; 63.72% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for EIF1AD Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
EIF1AD

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for EIF1AD Gene

Disorders for EIF1AD Gene

Relevant External Links for EIF1AD

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
EIF1AD

No disorders were found for EIF1AD Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for EIF1AD Gene

Publications for EIF1AD Gene

  1. Novel protein haponin regulates cellular response to oxidative stress. (PMID: 22095125) Smirnova E.V. … Lipkin V.M. (Dokl. Biochem. Biophys. 2011) 3 4 64
  2. Towards a proteome-scale map of the human protein-protein interaction network. (PMID: 16189514) Rual J.F. … Vidal M. (Nature 2005) 3 4 64
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 2 3 64
  5. Genome-wide association study identifies three novel susceptibility loci for severe Acne vulgaris. (PMID: 24927181) Navarini A.A. … Barker J.N. (Nat Commun 2014) 3 64

Products for EIF1AD Gene

Sources for EIF1AD Gene

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