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Aliases for EIF1AD Gene

Aliases for EIF1AD Gene

  • Eukaryotic Translation Initiation Factor 1A Domain Containing 2 3 5
  • Eukaryotic Translation Initiation Factor 1A Domain-Containing Protein 3 4
  • Haponin 3 4
  • Probable RNA-Binding Protein EIF1AD 3

External Ids for EIF1AD Gene

Previous GeneCards Identifiers for EIF1AD Gene

  • GC11M065522
  • GC11M065764
  • GC11M062090

Summaries for EIF1AD Gene

GeneCards Summary for EIF1AD Gene

EIF1AD (Eukaryotic Translation Initiation Factor 1A Domain Containing) is a Protein Coding gene. GO annotations related to this gene include RNA binding and translation initiation factor activity.

UniProtKB/Swiss-Prot for EIF1AD Gene

  • Plays a role into cellular response to oxidative stress. Decreases cell proliferation.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for EIF1AD Gene

Genomics for EIF1AD Gene

Regulatory Elements for EIF1AD Gene

Enhancers for EIF1AD Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH11F065470 2.5 VISTA FANTOM5 Ensembl ENCODE 43.3 +512.1 512093 40.0 MLX CREB3L1 ZFP64 FEZF1 DMAP1 YBX1 YY1 SLC30A9 ZNF143 ZNF263 LOC105369353 LOC105369352 KAT5 SSSCA1-AS1 NEAT1 ZFPL1 EIF1AD EHBP1L1 MRPL11 POLA2
GH11F065414 1.7 FANTOM5 ENCODE 57.3 +578.0 577995 18.8 CREB3L1 MLX ZFP64 YBX1 FEZF1 DMAP1 YY1 SLC30A9 ZNF143 ZNF263 NEAT1 ZFPL1 KAT5 EIF1AD LOC105369352 POLA2 MUS81 PCNX3 FRMD8 ENSG00000255320
GH11F065851 1.2 ENCODE 47.5 +144.7 144692 12.2 CREB3L1 MLX ZFP64 FEZF1 DMAP1 YY1 SLC30A9 ZNF143 ZNF263 SP3 SNX32 EIF1AD ZFPL1 PCNX3 POLA2 MRPL11 FRMD8 ENSG00000258297 NEAT1 ENSG00000255320
GH11F065886 1.6 FANTOM5 ENCODE 34.6 +106.7 106718 18.4 CREB3L1 ZFP64 FEZF1 DMAP1 YY1 SLC30A9 ZNF143 ZNF263 SP3 NFYC SNX32 CTSW MRPL11 EIF1AD NEAT1 MUS81 ENSG00000258297 KAT5 FAU POLA2
GH11F066342 1.8 FANTOM5 Ensembl ENCODE 29.8 -346.4 -346369 11.8 CREB3L1 MLX ZFP64 DMAP1 YY1 SLC30A9 ZNF143 SP3 NFYC TBX21 ENSG00000258297 RBM14 RIN1 MRPL11 SSSCA1-AS1 EIF1AD RCE1 LOC105369352 CD248 ACTN3
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around EIF1AD on UCSC Golden Path with GeneCards custom track

Promoters for EIF1AD Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000109964 76 2601 CREB3L1 ZFP64 FEZF1 DMAP1 YY1 SLC30A9 ZNF143 ZNF263 SP3 TBX21

Genomic Location for EIF1AD Gene

Chromosome:
11
Start:
65,996,545 bp from pter
End:
66,002,176 bp from pter
Size:
5,632 bases
Orientation:
Minus strand

Genomic View for EIF1AD Gene

Genes around EIF1AD on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
EIF1AD Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for EIF1AD Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for EIF1AD Gene

Proteins for EIF1AD Gene

  • Protein details for EIF1AD Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8N9N8-EIF1A_HUMAN
    Recommended name:
    Probable RNA-binding protein EIF1AD
    Protein Accession:
    Q8N9N8
    Secondary Accessions:
    • B2R4N5
    • Q9BSC1

    Protein attributes for EIF1AD Gene

    Size:
    165 amino acids
    Molecular mass:
    19053 Da
    Quaternary structure:
    • Interacts with GAPDH and STAT1.

    Three dimensional structures from OCA and Proteopedia for EIF1AD Gene

neXtProt entry for EIF1AD Gene

Post-translational modifications for EIF1AD Gene

  • Ubiquitination at Lys 56, Lys 98, and Lys 112
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for EIF1AD Gene

Domains & Families for EIF1AD Gene

Suggested Antigen Peptide Sequences for EIF1AD Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8N9N8

UniProtKB/Swiss-Prot:

EIF1A_HUMAN :
  • Contains 1 S1-like domain.
  • Belongs to the EIF1AD family.
Domain:
  • Contains 1 S1-like domain.
Family:
  • Belongs to the EIF1AD family.
genes like me logo Genes that share domains with EIF1AD: view

No data available for Gene Families for EIF1AD Gene

Function for EIF1AD Gene

Molecular function for EIF1AD Gene

UniProtKB/Swiss-Prot Function:
Plays a role into cellular response to oxidative stress. Decreases cell proliferation.

Gene Ontology (GO) - Molecular Function for EIF1AD Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003743 translation initiation factor activity IEA --
GO:0005515 protein binding IPI 16189514
genes like me logo Genes that share ontologies with EIF1AD: view
genes like me logo Genes that share phenotypes with EIF1AD: view

Animal Model Products

Inhibitory RNA Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for EIF1AD Gene

Localization for EIF1AD Gene

Subcellular locations from UniProtKB/Swiss-Prot for EIF1AD Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for EIF1AD gene
Compartment Confidence
nucleus 5
cytoskeleton 2
cytosol 2
mitochondrion 1

Gene Ontology (GO) - Cellular Components for EIF1AD Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA,IBA --
GO:0005654 nucleoplasm IDA --
GO:0043231 intracellular membrane-bounded organelle IDA --
GO:0045111 intermediate filament cytoskeleton IDA --
genes like me logo Genes that share ontologies with EIF1AD: view

Pathways & Interactions for EIF1AD Gene

SuperPathways for EIF1AD Gene

No Data Available

Gene Ontology (GO) - Biological Process for EIF1AD Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006413 translational initiation IEA --
genes like me logo Genes that share ontologies with EIF1AD: view

No data available for Pathways by source and SIGNOR curated interactions for EIF1AD Gene

Transcripts for EIF1AD Gene

Unigene Clusters for EIF1AD Gene

Eukaryotic translation initiation factor 1A domain containing:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for EIF1AD Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b · 3c ^ 4 ^ 5a · 5b ^ 6 ^ 7a · 7b
SP1: -
SP2: - -
SP3: - -
SP4: - - - -
SP5:

Relevant External Links for EIF1AD Gene

GeneLoc Exon Structure for
EIF1AD
ECgene alternative splicing isoforms for
EIF1AD

Expression for EIF1AD Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for EIF1AD Gene

Protein differential expression in normal tissues from HIPED for EIF1AD Gene

This gene is overexpressed in Peripheral blood mononuclear cells (12.5), Breast (11.1), Lung (9.7), CD8 Tcells (6.9), and Pancreas (6.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for EIF1AD Gene



Protein tissue co-expression partners for EIF1AD Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of EIF1AD Gene:

EIF1AD

SOURCE GeneReport for Unigene cluster for EIF1AD Gene:

Hs.425178

mRNA Expression by UniProt/SwissProt for EIF1AD Gene:

Q8N9N8-EIF1A_HUMAN
Tissue specificity: Expressed in the glioblastoma cell line U-87MG, the embryonic kidney cell line HEK293, the pancreatic carcinoma cell line PANC-1, the breast carcinoma cell line MCF-7, the lung cancer cell line NCI-H460, and the chronic myelogenous leukemia cell line K-562.
genes like me logo Genes that share expression patterns with EIF1AD: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for EIF1AD Gene

Orthologs for EIF1AD Gene

This gene was present in the common ancestor of animals.

Orthologs for EIF1AD Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia EIF1AD 34 35
  • 99.8 (n)
dog
(Canis familiaris)
Mammalia EIF1AD 34 35
  • 92.32 (n)
cow
(Bos Taurus)
Mammalia EIF1AD 34 35
  • 91.92 (n)
oppossum
(Monodelphis domestica)
Mammalia -- 35
  • 90 (a)
OneToMany
-- 35
  • 88 (a)
OneToMany
mouse
(Mus musculus)
Mammalia Eif1ad 34 16 35
  • 88.24 (n)
rat
(Rattus norvegicus)
Mammalia Eif1ad 34
  • 87.36 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia EIF1AD 35
  • 73 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia eif1ad 34
  • 66.45 (n)
zebrafish
(Danio rerio)
Actinopterygii eif1ad 34 35
  • 59.91 (n)
-- 34
fruit fly
(Drosophila melanogaster)
Insecta CG31957 34 35
  • 59.06 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP010181 34
  • 58.85 (n)
worm
(Caenorhabditis elegans)
Secernentea ZK856.11 34 35
  • 47.38 (n)
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 41 (a)
OneToOne
Species where no ortholog for EIF1AD was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for EIF1AD Gene

ENSEMBL:
Gene Tree for EIF1AD (if available)
TreeFam:
Gene Tree for EIF1AD (if available)

Paralogs for EIF1AD Gene

No data available for Paralogs for EIF1AD Gene

Variants for EIF1AD Gene

Sequence variations from dbSNP and Humsavar for EIF1AD Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type
rs387906871 Pathogenic 66,003,284(+) TCGTG(A/G)CAGAG upstream-variant-2KB, reference, missense
rs1047464 -- 66,001,985(+) AGAGG(A/T)TCGTC intron-variant, upstream-variant-2KB, utr-variant-5-prime
rs111702851 -- 65,999,031(+) ACATA(A/G)CAGAT intron-variant
rs11227374 -- 65,996,250(+) TAGCC(A/G)GGCGT downstream-variant-500B
rs113448289 -- 65,999,751(+) GTTCT(A/G)TCTCC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for EIF1AD Gene

Variant ID Type Subtype PubMed ID
nsv819658 CNV loss 19587683
nsv832191 CNV loss 17160897

Variation tolerance for EIF1AD Gene

Residual Variation Intolerance Score: 54.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.40; 63.72% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for EIF1AD Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
EIF1AD

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for EIF1AD Gene

Disorders for EIF1AD Gene

Relevant External Links for EIF1AD

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
EIF1AD

No disorders were found for EIF1AD Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for EIF1AD Gene

Publications for EIF1AD Gene

  1. Novel protein haponin regulates cellular response to oxidative stress. (PMID: 22095125) Smirnova E.V. … Lipkin V.M. (Dokl. Biochem. Biophys. 2011) 3 4 64
  2. Towards a proteome-scale map of the human protein-protein interaction network. (PMID: 16189514) Rual J.F. … Vidal M. (Nature 2005) 3 4 64
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 2 3 64
  5. Genome-wide association study identifies three novel susceptibility loci for severe Acne vulgaris. (PMID: 24927181) Navarini A.A. … Barker J.N. (Nat Commun 2014) 3 64

Products for EIF1AD Gene

Sources for EIF1AD Gene

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