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Aliases for EIF1AD Gene

Aliases for EIF1AD Gene

  • Eukaryotic Translation Initiation Factor 1A Domain Containing 2 3 5
  • Eukaryotic Translation Initiation Factor 1A Domain-Containing Protein 3 4
  • Haponin 3 4

External Ids for EIF1AD Gene

Previous GeneCards Identifiers for EIF1AD Gene

  • GC11M065522
  • GC11M065764
  • GC11M062090

Summaries for EIF1AD Gene

GeneCards Summary for EIF1AD Gene

EIF1AD (Eukaryotic Translation Initiation Factor 1A Domain Containing) is a Protein Coding gene. GO annotations related to this gene include RNA binding and translation initiation factor activity.

UniProtKB/Swiss-Prot for EIF1AD Gene

  • Plays a role into cellular response to oxidative stress. Decreases cell proliferation.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for EIF1AD Gene

Genomics for EIF1AD Gene

Regulatory Elements for EIF1AD Gene

Promoters for EIF1AD Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around EIF1AD on UCSC Golden Path with GeneCards custom track

Genomic Location for EIF1AD Gene

Chromosome:
11
Start:
65,996,545 bp from pter
End:
66,002,176 bp from pter
Size:
5,632 bases
Orientation:
Minus strand

Genomic View for EIF1AD Gene

Genes around EIF1AD on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
EIF1AD Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for EIF1AD Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for EIF1AD Gene

Proteins for EIF1AD Gene

  • Protein details for EIF1AD Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8N9N8-EIF1A_HUMAN
    Recommended name:
    Probable RNA-binding protein EIF1AD
    Protein Accession:
    Q8N9N8
    Secondary Accessions:
    • B2R4N5
    • Q9BSC1

    Protein attributes for EIF1AD Gene

    Size:
    165 amino acids
    Molecular mass:
    19053 Da
    Quaternary structure:
    • Interacts with GAPDH and STAT1.

    Three dimensional structures from OCA and Proteopedia for EIF1AD Gene

neXtProt entry for EIF1AD Gene

Proteomics data for EIF1AD Gene at MOPED

Post-translational modifications for EIF1AD Gene

  • Ubiquitination at Lys 56, Lys 98, and Lys 112
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for EIF1AD Gene

Domains & Families for EIF1AD Gene

Protein Domains for EIF1AD Gene

Suggested Antigen Peptide Sequences for EIF1AD Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8N9N8

UniProtKB/Swiss-Prot:

EIF1A_HUMAN :
  • Contains 1 S1-like domain.
  • Belongs to the EIF1AD family.
Domain:
  • Contains 1 S1-like domain.
Family:
  • Belongs to the EIF1AD family.
genes like me logo Genes that share domains with EIF1AD: view

No data available for Gene Families for EIF1AD Gene

Function for EIF1AD Gene

Molecular function for EIF1AD Gene

UniProtKB/Swiss-Prot Function:
Plays a role into cellular response to oxidative stress. Decreases cell proliferation.
genes like me logo Genes that share phenotypes with EIF1AD: view

Animal Model Products

CRISPR Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for EIF1AD Gene

Localization for EIF1AD Gene

Subcellular locations from UniProtKB/Swiss-Prot for EIF1AD Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for EIF1AD Gene COMPARTMENTS Subcellular localization image for EIF1AD gene
Compartment Confidence
cytoskeleton 5
nucleus 5
cytosol 2
mitochondrion 1

Gene Ontology (GO) - Cellular Components for EIF1AD Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0043231 intracellular membrane-bounded organelle IDA --
genes like me logo Genes that share ontologies with EIF1AD: view

Pathways & Interactions for EIF1AD Gene

SuperPathways for EIF1AD Gene

No Data Available

Gene Ontology (GO) - Biological Process for EIF1AD Gene

None

No data available for Pathways by source and SIGNOR curated interactions for EIF1AD Gene

Drugs & Compounds for EIF1AD Gene

No Compound Related Data Available

Transcripts for EIF1AD Gene

Unigene Clusters for EIF1AD Gene

Eukaryotic translation initiation factor 1A domain containing:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for EIF1AD Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b · 3c ^ 4 ^ 5a · 5b ^ 6 ^ 7a · 7b
SP1: -
SP2: - -
SP3: - -
SP4: - - - -
SP5:

Relevant External Links for EIF1AD Gene

GeneLoc Exon Structure for
EIF1AD
ECgene alternative splicing isoforms for
EIF1AD

Expression for EIF1AD Gene

mRNA expression in normal human tissues for EIF1AD Gene

Protein differential expression in normal tissues from HIPED for EIF1AD Gene

This gene is overexpressed in Peripheral blood mononuclear cells (12.5), Breast (11.1), Lung (9.7), CD8 Tcells (6.9), and Pancreas (6.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for EIF1AD Gene



SOURCE GeneReport for Unigene cluster for EIF1AD Gene Hs.425178

mRNA Expression by UniProt/SwissProt for EIF1AD Gene

Q8N9N8-EIF1A_HUMAN
Tissue specificity: Expressed in the glioblastoma cell line U-87MG, the embryonic kidney cell line HEK293, the pancreatic carcinoma cell line PANC-1, the breast carcinoma cell line MCF-7, the lung cancer cell line NCI-H460, and the chronic myelogenous leukemia cell line K-562.
genes like me logo Genes that share expression patterns with EIF1AD: view

Protein tissue co-expression partners for EIF1AD Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for EIF1AD Gene

Orthologs for EIF1AD Gene

This gene was present in the common ancestor of animals.

Orthologs for EIF1AD Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia EIF1AD 35
  • 99.8 (n)
  • 100 (a)
EIF1AD 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia EIF1AD 36
  • 95 (a)
OneToOne
EIF1AD 35
  • 91.92 (n)
  • 94.55 (a)
dog
(Canis familiaris)
Mammalia EIF1AD 35
  • 92.32 (n)
  • 97.58 (a)
EIF1AD 36
  • 97 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Eif1ad 35
  • 88.24 (n)
  • 91.5 (a)
Eif1ad 36
  • 89 (a)
OneToOne
Eif1ad 16
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 88 (a)
OneToMany
-- 36
  • 90 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia EIF1AD 36
  • 73 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Eif1ad 35
  • 87.36 (n)
  • 91.5 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia eif1ad 35
  • 66.45 (n)
  • 65.13 (a)
zebrafish
(Danio rerio)
Actinopterygii eif1ad 36
  • 56 (a)
OneToOne
-- 35
eif1ad 35
  • 59.91 (n)
  • 61.49 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP010181 35
  • 58.85 (n)
  • 57.81 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG31957 36
  • 43 (a)
OneToOne
CG31957 35
  • 59.06 (n)
  • 50 (a)
worm
(Caenorhabditis elegans)
Secernentea ZK856.11 35
  • 47.38 (n)
  • 40.5 (a)
ZK856.11 36
  • 34 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 41 (a)
OneToOne
Species with no ortholog for EIF1AD:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for EIF1AD Gene

ENSEMBL:
Gene Tree for EIF1AD (if available)
TreeFam:
Gene Tree for EIF1AD (if available)

Paralogs for EIF1AD Gene

No data available for Paralogs for EIF1AD Gene

Variants for EIF1AD Gene

Sequence variations from dbSNP and Humsavar for EIF1AD Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type
VAR_037851 -
rs2276017 - 65,998,621(+) CTTCA(C/T)TCTCC reference, missense
rs2030 -- 65,996,761(+) acgct(C/T)gACAC utr-variant-3-prime
rs540584 -- 65,998,395(+) TCTCC(C/G)TCCCC utr-variant-3-prime
rs610497 -- 65,998,080(-) TCCCC(A/G)CCTTT utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for EIF1AD Gene

Variant ID Type Subtype PubMed ID
nsv832191 CNV Loss 17160897
dgv1186n71 CNV Loss 21882294
nsv819658 CNV Loss 19587683

Variation tolerance for EIF1AD Gene

Residual Variation Intolerance Score: 54.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.40; 63.72% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for EIF1AD Gene

HapMap Linkage Disequilibrium report
EIF1AD

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for EIF1AD Gene

Disorders for EIF1AD Gene

Relevant External Links for EIF1AD

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
EIF1AD

No disorders were found for EIF1AD Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for EIF1AD Gene

Publications for EIF1AD Gene

  1. Novel protein haponin regulates cellular response to oxidative stress. (PMID: 22095125) Smirnova E.V. … Lipkin V.M. (Dokl. Biochem. Biophys. 2011) 3 4 67
  2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 2 3
  3. Genome-wide association study identifies three novel susceptibility loci for severe Acne vulgaris. (PMID: 24927181) Navarini A.A. … Barker J.N. (Nat Commun 2014) 3
  4. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 3
  5. Insights into RNA biology from an atlas of mammalian mRNA-binding proteins. (PMID: 22658674) Castello A. … Hentze M.W. (Cell 2012) 3

Products for EIF1AD Gene

Sources for EIF1AD Gene

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