Free for academic non-profit institutions. Other users need a Commercial license

Aliases for EIF1 Gene

Aliases for EIF1 Gene

  • Eukaryotic Translation Initiation Factor 1 2 3
  • Protein Translation Factor SUI1 Homolog 3 4
  • Sui1iso1 3 4
  • A121 3 4
  • SUI1 3 4
  • EIF-1 3
  • EIF1A 3
  • ISO1 3
  • EIF1 4

External Ids for EIF1 Gene

Previous GeneCards Identifiers for EIF1 Gene

  • GC00U990093
  • GC17P037099
  • GC17P039845
  • GC17P035607

Summaries for EIF1 Gene

GeneCards Summary for EIF1 Gene

EIF1 (Eukaryotic Translation Initiation Factor 1) is a Protein Coding gene. Among its related pathways are Apoptotic Pathways in Synovial Fibroblasts and Translational Control. GO annotations related to this gene include poly(A) RNA binding and translation factor activity, RNA binding. An important paralog of this gene is EIF1B.

UniProtKB/Swiss-Prot for EIF1 Gene

  • Necessary for scanning and involved in initiation site selection. Promotes the assembly of 48S ribosomal complexes at the authentic initiation codon of a conventional capped mRNA

Gene Wiki entry for EIF1 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for EIF1 Gene

Genomics for EIF1 Gene

Regulatory Elements for EIF1 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for EIF1 Gene

Chromosome:
17
Start:
41,688,875 bp from pter
End:
41,692,668 bp from pter
Size:
3,794 bases
Orientation:
Plus strand

Genomic View for EIF1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
GeneLoc Logo Gene Density

RefSeq DNA sequence for EIF1 Gene

Proteins for EIF1 Gene

  • Protein details for EIF1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P41567-EIF1_HUMAN
    Recommended name:
    Eukaryotic translation initiation factor 1
    Protein Accession:
    P41567
    Secondary Accessions:
    • Q9UNQ9

    Protein attributes for EIF1 Gene

    Size:
    113 amino acids
    Molecular mass:
    12732 Da
    Quaternary structure:
    • Interacts with RENT2.

    Three dimensional structures from OCA and Proteopedia for EIF1 Gene

neXtProt entry for EIF1 Gene

Proteomics data for EIF1 Gene at MOPED

Post-translational modifications for EIF1 Gene

  • Ubiquitination at Lys 91
  • Modification sites at PhosphoSitePlus

Other Protein References for EIF1 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for EIF1 (eIF1)

No data available for DME Specific Peptides for EIF1 Gene

Domains & Families for EIF1 Gene

Protein Domains for EIF1 Gene

Suggested Antigen Peptide Sequences for EIF1 Gene

Graphical View of Domain Structure for InterPro Entry

P41567

UniProtKB/Swiss-Prot:

EIF1_HUMAN :
  • Belongs to the SUI1 family.
Family:
  • Belongs to the SUI1 family.
genes like me logo Genes that share domains with EIF1: view

No data available for Gene Families for EIF1 Gene

Function for EIF1 Gene

Molecular function for EIF1 Gene

UniProtKB/Swiss-Prot Function:
Necessary for scanning and involved in initiation site selection. Promotes the assembly of 48S ribosomal complexes at the authentic initiation codon of a conventional capped mRNA

Gene Ontology (GO) - Molecular Function for EIF1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003743 translation initiation factor activity NAS 10347211
GO:0008135 translation factor activity, RNA binding TAS 10347211
GO:0044822 poly(A) RNA binding IDA 22681889
genes like me logo Genes that share ontologies with EIF1: view
genes like me logo Genes that share phenotypes with EIF1: view

Animal Model Products

miRNA for EIF1 Gene

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for EIF1

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targets and HOMER Transcription for EIF1 Gene

Localization for EIF1 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for EIF1 Gene COMPARTMENTS Subcellular localization image for EIF1 gene
Compartment Confidence
nucleus 5
cytosol 1

Gene Ontology (GO) - Cellular Components for EIF1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA 12426392
GO:0005737 cytoplasm IDA 12426392
genes like me logo Genes that share ontologies with EIF1: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for EIF1 Gene

Pathways & Interactions for EIF1 Gene

genes like me logo Genes that share pathways with EIF1: view

Pathways by source for EIF1 Gene

2 Qiagen pathways for EIF1 Gene
1 Cell Signaling Technology pathway for EIF1 Gene
1 BioSystems pathway for EIF1 Gene
1 KEGG pathway for EIF1 Gene

Gene Ontology (GO) - Biological Process for EIF1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006413 translational initiation IEA --
GO:0006446 regulation of translational initiation IDA 22156057
GO:0006950 response to stress NAS 10347211
GO:0009048 dosage compensation by inactivation of X chromosome IEA --
genes like me logo Genes that share ontologies with EIF1: view

No data available for SIGNOR curated interactions for EIF1 Gene

Drugs & Compounds for EIF1 Gene

(2) Additional Compounds for EIF1 Gene - From: NovoSeek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
gtp
Partial agonist, Agonist
tRNA
genes like me logo Genes that share compounds with EIF1: view

Transcripts for EIF1 Gene

Unigene Clusters for EIF1 Gene

Eukaryotic translation initiation factor 1:
Representative Sequences:

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for EIF1

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for EIF1 Gene

ExUns: 1a · 1b · 1c · 1d · 1e ^ 2a · 2b ^ 3a · 3b ^ 4a · 4b · 4c · 4d · 4e
SP1: - -
SP2: - -
SP3: - - -
SP4: - -
SP5: -
SP6:

Relevant External Links for EIF1 Gene

GeneLoc Exon Structure for
EIF1
ECgene alternative splicing isoforms for
EIF1

Expression for EIF1 Gene

mRNA expression in normal human tissues for EIF1 Gene

Protein differential expression in normal tissues from HIPED for EIF1 Gene

This gene is overexpressed in Fetal ovary (8.7), NK cells (7.6), and Spinal cord (7.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for EIF1 Gene



SOURCE GeneReport for Unigene cluster for EIF1 Gene Hs.150580

genes like me logo Genes that share expression patterns with EIF1: view

Protein tissue co-expression partners for EIF1 Gene

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for EIF1 Gene

Orthologs for EIF1 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for EIF1 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia EIF1 35
  • 97.94 (n)
  • 100 (a)
EIF1 36
  • 100 (a)
OneToOne
dog
(Canis familiaris)
Mammalia EIF1 35
  • 97.94 (n)
  • 100 (a)
SUI1ISO1 36
  • 100 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia EIF1 35
  • 100 (n)
  • 100 (a)
EIF1 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Eif1l1 35
  • 97.64 (n)
  • 98.23 (a)
mouse
(Mus musculus)
Mammalia Eif1 16
Eif1 36
  • 99 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia EIF1 36
  • 43 (a)
OneToOne
chicken
(Gallus gallus)
Aves EIF1 35
  • 89.68 (n)
  • 98.23 (a)
EIF1 36
  • 83 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia EIF1 36
  • 99 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia eif1 35
  • 77.88 (n)
  • 86.73 (a)
zebrafish
(Danio rerio)
Actinopterygii eif1b 35
  • 82.01 (n)
  • 92.04 (a)
wufb54a12 35
eif1b 36
  • 92 (a)
ManyToMany
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.11829 35
fruit fly
(Drosophila melanogaster)
Insecta CG17737 36
  • 71 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea eif-1 36
  • 52 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes SUI1 36
  • 61 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.6142 36
  • 67 (a)
OneToMany
Species with no ortholog for EIF1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for EIF1 Gene

ENSEMBL:
Gene Tree for EIF1 (if available)
TreeFam:
Gene Tree for EIF1 (if available)

Paralogs for EIF1 Gene

Paralogs for EIF1 Gene

(3) SIMAP similar genes for EIF1 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with EIF1: view

Variants for EIF1 Gene

Sequence variations from dbSNP and Humsavar for EIF1 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type MAF
rs3385 -- 41,690,827(-) AAGCA(C/T)TTAAA utr-variant-3-prime
rs3386 -- 41,690,799(-) TGATC(A/G)TCCTT reference, synonymous-codon
rs3387 - 41,690,160(-) CTTGC(C/G)TTGGT reference, missense
rs3388 -- 41,690,159(-) TTGCG(C/T)TGGTC reference, synonymous-codon
rs3389 -- 41,690,123(-) TATTC(C/T)GGATG synonymous-codon, reference

Structural Variations from Database of Genomic Variants (DGV) for EIF1 Gene

Variant ID Type Subtype PubMed ID
dgv961e1 CNV Complex 17122850
dgv962e1 CNV Complex 17122850

Variation tolerance for EIF1 Gene

Residual Variation Intolerance Score: 50.73% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.66; 56.99% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for EIF1 Gene

HapMap Linkage Disequilibrium report
EIF1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for EIF1 Gene

Disorders for EIF1 Gene

Relevant External Links for EIF1

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
EIF1
genes like me logo Genes that share disorders with EIF1: view

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for EIF1 Gene

Publications for EIF1 Gene

  1. The role of ABCE1 in eukaryotic posttermination ribosomal recycling. (PMID: 20122402) Pisarev A.V. … Pestova T.V. (Mol. Cell 2010) 23 67
  2. Position of eukaryotic translation initiation factor eIF1A on the 40S ribosomal subunit mapped by directed hydroxyl radical probing. (PMID: 19561193) Yu Y. … Pestova T.V. (Nucleic Acids Res. 2009) 23 67
  3. eIF1 controls multiple steps in start codon recognition during eukaryotic translation initiation. (PMID: 19751744) Nanda J.S. … Lorsch J.R. (J. Mol. Biol. 2009) 23 67
  4. Should I stay or should I go? Eukaryotic translation initiation factors 1 and 1A control start codon recognition. (PMID: 18593708) Mitchell S.F. … Lorsch J.R. (J. Biol. Chem. 2008) 23 67
  5. Translation initiation factor 2gamma mutant alters start codon selection independent of Met-tRNA binding. (PMID: 18794367) Alone P.V. … Dever T.E. (Mol. Cell. Biol. 2008) 23 67

Products for EIF1 Gene

Sources for EIF1 Gene

Back to Top

Content