EIF1 Gene
protein-coding GIFtS: 53
GCID: GC17P039845
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eukaryotic translation initiation factor 1
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Aliases
for EIF1 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Eukaryotic Translation Initiation Factor 11 2 | | ISO11 2 | | A1211 2 3 | | Protein Translation Factor SUI1 Homolog2 3 | | SUI11 2 3 | | Sui1iso13 | | EIF-11 2 | | Sui1iso13 | | EIF1A1 2 | | EIF11 |
Export aliases for EIF1 gene to outside databasesPrevious GC identifers: GC00U990093 GC17P037099 GC17P035607 |
Summaries
for EIF1 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
UniProtKB/Swiss-Prot: EIF1_HUMAN, P41567Function: Necessary for scanning and involved in initiation site selection. Promotes the assembly of 48S ribosomalcomplexes at the authentic initiation codon of a conventional capped mRNA
Gene Wiki entry for EIF1
|
Genomic Views
for EIF1 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000017.10 NC_018928.1 NT_010783.15
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the EIF1 gene promoter:
C/EBPbeta C/EBPalpha AREB6 NF-AT4 NF-AT2 Cart-1 NF-AT3 NF-Y CBF(2) NF-AT1
Other transcription factors
Search SABiosciences Chromatin IP Primers for EIF1
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat EIF1 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 17q21.2 Ensembl cytogenetic band: 17q21.2 HGNC cytogenetic band: 17q21.2EIF1 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 17 GeneLoc Exon Structure GeneLoc location for GC17P039845: view genomic region
(about GC identifiers)
Start:
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39,845,127 bp from pter |
End:
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39,848,920 bp from pter |
Size:
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3,794 bases |
Orientation:
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plus strand |
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Proteins
for EIF1 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: EIF1_HUMAN, P41567 (See
protein sequence)Recommended Name: Eukaryotic translation initiation factor 1 Size: 113 amino acids; 12732 Da
Subunit: Interacts with RENT2
1 PDB 3D structure from  and Proteopedia  for EIF1:2IF1 (3D)
Secondary accessions: Q9UNQ9Explore the universe of human proteins at neXtProt for EIF1: NX_P41567
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_P41567
EIF1 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_005792.1
ENSEMBL proteins: ENSP00000466321 ENSP00000419449 ENSP00000467918
Human Recombinant Protein Products:
Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table
EIF1 for ontologies About GeneDecksing
EIF1 Antibody Products:
Assay Products for EIF1: |
Protein
Domains /
Families
for EIF1 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
EIF1 for domains About GeneDecksing
2 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry P41567ProtoNet protein and cluster: P41567 1 Blocks protein family: IPB001950 Translation initiation factor SUI1
UniProtKB/Swiss-Prot: EIF1_HUMAN, P41567Similarity: Belongs to the SUI1 family |
Function
for EIF1 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: EIF1_HUMAN, P41567Function: Necessary for scanning and involved in initiation site selection. Promotes the assembly of 48S ribosomalcomplexes at the authentic initiation codon of a conventional capped mRNA
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for EIF1 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for EIF1
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: EIF1 (NM_001412) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for EIF1 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat EIF1 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for EIF1 |
Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view): About this table
EIF1 for ontologies About GeneDecksing
|
Pathways & Interactions
for EIF1 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | Translation Factors | | | 2 | RNA transport | |
Pathway sources
See GeneCards unified pathways
Show all pathways
1  BioSystems Pathway for EIF1
1 
Kegg Pathway (Kegg details for EIF1):
EIF1 for pathways About GeneDecksing
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for EIF1
STRING Interaction
Network Preview (showing 5 interactants - click image to see 25)
5/106 Interacting proteins for EIF1 (P415672, 3 ENSP000004194494) via UniProtKB, MINT, STRING, and/or I2D (see all 106)About this table
Gene Ontology (GO): 4 biological process terms (GO ID links to tree view): About this table
EIF1 for ontologies About GeneDecksing
|
Drugs & Compounds
for EIF1 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
EIF1 for compounds About GeneDecksing
 Browse Tocris compounds for EIF1
2 Novoseek chemical compound relationships for EIF1 gene About this table
Search CenterWatch for drugs/clinical trials and news about EIF1
|
Transcripts
for EIF1 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for EIF1 gene: NM_005801.3 Unigene Cluster for EIF1: Eukaryotic translation initiation factor 1 Hs.150580 [show with all ESTs]Unigene Representative Sequence: BQ2784558 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000462917(uc002hxj.3 uc002hxk.3) ENST00000591776 ENST00000469257
ENST00000482111 ENST00000310837 ENST00000469308 ENST00000479972 ENST00000586699
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for EIF1 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for EIF1
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: EIF1 (NM_001412) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for EIF1 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat EIF1 |
Additional cDNA sequence: AF083441.1 AF100737.1 AJ012375.1 AK311209.1 AK311862.1 BC005118.1 BC008710.1 BT006645.1 CR457051.1 L26247.1 24/54 DOTS entries (see all 54): DT.97857707 DT.87017930 DT.87000962 DT.100060625 DT.100688807 DT.91769712 DT.100688802 DT.95170862 DT.91932427 DT.40124100 DT.95170828 DT.100688801 DT.95170729 DT.121022158 DT.92379834 DT.120959094 DT.120959090 DT.120959114 DT.100688811 DT.100866432 DT.120959199 DT.97852514 DT.97852539 DT.100688792 24/2215 AceView cDNA sequences (see all 2215): N90225 BQ777882 F26248 BU071320 BG109357 CR595493 BQ684573 CA306140 CR615866 CA417695 BQ684557 W33150 F03131 CR606182 BM772792 BM550265 BM758715 BU077711 F35497 AV660675 AW025390 BU731134 BI715166 AA581967
GeneLoc Exon Structure
5/6 Alternative Splicing Database (ASD) splice patterns (SP) for EIF1 (see all 6) About this scheme
| ExUns: | 1a | · | 1b | · | 1c | · | 1d | · | 1e | ^ | 2a | · | 2b | ^ | 3a | · | 3b | ^ | 4a | · | 4b | · | 4c | · | 4d | · | 4e |
|---|
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| SP1: | | | | | | | | | - | | - | | | | | | | | | | | | | | | | | | |
| SP2: | | | | | | | | | - | | - | | | | | | | | | | | | | | | | | | |
| SP3: | | | | | | | | | - | | - | | - | | | | | | | | | | | | | | | | |
| SP4: | | | | | | | | | - | | - | | | | | | | | | | | | | | | | | | |
| SP5: | | | | | | | | | | | - | | | | | | | | | | | | | | | | | |
ECgene alternative splicing isoforms for EIF1
|
Expression
for EIF1 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| EIF1 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: CAATAAACTG
About this image
See EIF1 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for EIF1
SOURCE GeneReport for Unigene cluster: Hs.150580
SABiosciences Custom PCR Arrays for EIF1
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for EIF1
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat EIF1 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat EIF1 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat EIF1 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for EIF1 |
Orthologs
for EIF1 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of eukaryotes.
Orthologs for EIF1 gene from 7/30 species (see all 30) About this table
ENSEMBL Gene Tree for EIF1 (if available)
TreeFam Gene Tree for EIF1 (if available) |
Paralogs
for EIF1 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for EIF1 gene
- EIF1B2
3 SIMAP similar genes for EIF1 using alignment to 3 protein entries: EIF1_HUMAN (see all proteins):SUI1 EIF1B GC20
EIF1 for paralogs About GeneDecksing
5/7 Pseudogenes.org Pseudogenes for EIF1 (see all 7)
PGOHUM00000248699 PGOHUM00000236978 PGOHUM00000234120 PGOHUM00000243973 PGOHUM00000245114
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Genomic Variants
for EIF1 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 17 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for EIF1 (39845127 - 39848920 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 2 variations for EIF1
2 CNVs: 3145 4036 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing EIF1 |
|
Disorders
/ Diseases
for EIF1 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
EIF1 for disorders About GeneDecksing
5  diseases for EIF1: About MalaCardsvestibular neuronitis hepatitis b hepatitis neuronitis
malaria
Export disorders for EIF1 gene to outside databases
|
Publications
for EIF1 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for EIF1 gene, integrated from 9 sources (see all 43):
(articles sorted by number of sources associating them with EIF1) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Cloning and characterization of a human genotoxic and endoplasmic reticulum stress-inducible cDNA that encodes translation initiation factor 1 (eIF1(A121/SUI1)). (PubMed id 10347211)1, 2, 3 Sheikh M.S.... Fornace A.J. Jr. (1999)
- Expressed sequence tags identify a human isolog of the suil translation initiation factor. (PubMed id 7904817)1, 2, 3 Fields C.A. and Adams M.D. (1994)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Novel Upf2p orthologues suggest a functional link between translation initiation and nonsense surveillance complexes. (PubMed id 11073994)1, 2 Mendell J.T.... Dietz H.C. (2000)
- Structure and interactions of the translation initiation factor eIF1. (PubMed id 10228174)1, 2 Fletcher C.M.... Wagner G. (1999)
- A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (2012)
- Methods for quantification of in vivo changes in prote in ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724)1 Udeshi N.D....Carr S.A. (2012)
- Proteome-wide identification of ubiquitylation sites b y conjugation of engineered lysine-less ubiquitin. (PubMed id 22053931)1 Oshikawa K....Nakayama K.I. (2012)
- A proteome-wide, quantitative survey of in vivo ubiqui tylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (2011)
- A directed protein interaction network for investigat ing intracellular signal transduction. (PubMed id 21900206)1 Vinayagam A....Wanker E.E. (2011)
|
External Searches for EIF1 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing EIF1 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing EIF1 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing EIF1 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
|
About This Section
| Patent Information for EIF1 gene:
Search GeneIP for patents involving EIF1
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for EIF1 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | OriGene Antibodies for EIF1 | | OriGene shRNA RFP for EIF1 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for EIF1 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for EIF1 | | | OriGene Protein Over-expression Lysate for EIF1 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for EIF1 | | OriGene 3'-UTR Clone for EIF1 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for EIF1 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for EIF1 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | OriGene Purified Protein for EIF1 | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for EIF1 | | OriGene Custom Protein Services for EIF1 | | | OriGene Custom Immunoassay Development | | |
| |
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 |
| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat EIF1 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing EIF1 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat EIF1 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat EIF1 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat EIF1 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat EIF1 |
| |
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| |  |  |  |  | | | | | | Recombinant Protein for EIF1 |
|
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 | | | EIF1 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for EIF1 |
|  |  |  | | | | Search ThermoFisher Antibodies for EIF1 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat EIF1 |
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