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EIF1 Gene

protein-coding   GIFtS: 57
GCID: GC17P039845

Eukaryotic Translation Initiation Factor 1

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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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This gene clusters with an RNA gene
Subcategory (RNA class): lncRNA

Quality score for the ORGUL clustered with this gene is 3

Aliases
Eukaryotic Translation Initiation Factor 11 2     ISO12
Protein Translation Factor SUI1 Homolog2 3     sui1iso12
A1212 3     Sui1iso13
SUI12 3     eIF13
EIF-12     EIF1AY5
EIF1A2     

External Ids:    HGNC: 32491   Entrez Gene: 102092   Ensembl: ENSG000001738127   OMIM: 4000145   UniProtKB: P415673   
ORGUL members:         

Export aliases for EIF1 gene to outside databases

Previous GC identifers: GC00U990093 GC17P037099 GC17P035607


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for EIF1 Gene:
EIF1 (eukaryotic translation initiation factor 1) is a protein-coding gene. GO annotations related to this gene include translation factor activity, nucleic acid binding and translation initiation factor activity. An important paralog of this gene is EIF1B.

UniProtKB/Swiss-Prot: EIF1_HUMAN, P41567
Function: Necessary for scanning and involved in initiation site selection. Promotes the assembly of 48S ribosomal
complexes at the authentic initiation codon of a conventional capped mRNA

Gene Wiki entry for EIF1 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000017.10  NC_018928.2  NT_010783.16  
Regulatory elements:
   Regulatory transcription factor binding sites in the EIF1 gene promoter:
         C/EBPbeta   C/EBPalpha   AREB6   NF-AT4   NF-AT2   Cart-1   NF-AT3   NF-Y   CBF(2)   NF-AT1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidEIF1 promoter sequence
   Search Chromatin IP Primers for EIF1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat EIF1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 17q21.2   Ensembl cytogenetic band:  17q21.2   HGNC cytogenetic band: 17q21.2

EIF1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
EIF1 gene location

GeneLoc information about chromosome 17         GeneLoc Exon Structure

GeneLoc location for GC17P039845:  view genomic region     (about GC identifiers)

Start:
39,845,127 bp from pter      End:
39,848,920 bp from pter
Size:
3,794 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: EIF1_HUMAN, P41567 (See protein sequence)
Recommended Name: Eukaryotic translation initiation factor 1  
Size: 113 amino acids; 12732 Da
Subunit: Interacts with RENT2
3 PDB 3D structures from and Proteopedia for EIF1:
2IF1 (3D)        4KZX (3D)        4KZY (3D)    
Secondary accessions: Q9UNQ9

Explore the universe of human proteins at neXtProt for EIF1: NX_P41567

Explore proteomics data for EIF1 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys42, Lys91
  • Modification sites at PhosphoSitePlus

  • See EIF1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_005792.1  
    ENSEMBL proteins: 
     ENSP00000466321   ENSP00000419449   ENSP00000467918  

    EIF1 Human Recombinant Protein Products:

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    OriGene Purified Protein for EIF1
    OriGene Protein Over-expression Lysate for EIF1
    OriGene MassSpec for EIF1
    OriGene Custom Protein Services for EIF1
    GenScript Custom Purified and Recombinant Proteins Services for EIF1
    Novus Biologicals EIF1 Proteins
    Novus Biologicals EIF1 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    ProSpec Recombinant Protein for EIF1
    Cloud-Clone Corp. Proteins for EIF1

     
    Search eBioscience for Proteins for EIF1 

     
    antibodies-online proteins for EIF1 (19 products) 

     
    antibodies-online peptides for EIF1

    EIF1 Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
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    Novus Biologicals EIF1 Antibodies
    Search for Antibodies for EIF1 at Abcam
    Cloud-Clone Corp. Antibodies for EIF1
    ThermoFisher Antibody for EIF1
    antibodies-online antibodies for EIF1 (21 products) 

    EIF1 Assay Products:

    Browse Kits and Assays available from EMD Millipore
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    GenScript Custom Assay Services for EIF1
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for EIF1
    Cloud-Clone Corp. CLIAs for EIF1
    Search eBioscience for ELISAs for EIF1 
    antibodies-online kits for EIF1 (8 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    2 InterPro protein domains:
     IPR001950 TIF_SUI1
     IPR005874 SUI1_euk

    Graphical View of Domain Structure for InterPro Entry P41567

    ProtoNet protein and cluster: P41567

    1 Blocks protein domain: IPB001950 Translation initiation factor SUI1

    UniProtKB/Swiss-Prot: EIF1_HUMAN, P41567
    Similarity: Belongs to the SUI1 family


    Find genes that share domains with EIF1           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: EIF1_HUMAN, P41567
    Function: Necessary for scanning and involved in initiation site selection. Promotes the assembly of 48S ribosomal
    complexes at the authentic initiation codon of a conventional capped mRNA

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003743translation initiation factor activity NAS10347211
    GO:0008135translation factor activity, nucleic acid binding TAS10347211
    GO:0044822poly(A) RNA binding IDA--
         
    Find genes that share ontologies with EIF1           About GenesLikeMe


    Animal Models:
       genOway: Develop your customized and physiologically relevant rodent model for EIF1

    miRNA
    Products:
        
    miRTarBase miRNAs that target EIF1:
    hsa-mir-10a-5p (MIRT047677), hsa-mir-10b-5p (MIRT047434), hsa-mir-16-5p (MIRT031390), hsa-mir-193b-3p (MIRT041198), hsa-mir-30a-5p (MIRT028444), hsa-mir-186-5p (MIRT044979)

    Block miRNA regulation of human, mouse, rat EIF1 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate EIF1 (see all 25):
    hsa-miR-623 hsa-miR-323-3p hsa-miR-4317 hsa-miR-100* hsa-miR-4328 hsa-miR-300 hsa-miR-522 hsa-miR-570
    SwitchGear 3'UTR luciferase reporter plasmidEIF1 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for EIF1
    Predesigned siRNA for gene silencing in human, mouse, rat EIF1

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for EIF1

    Clone
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    OriGene clones in human, mouse for EIF1 (see all 6)
    OriGene ORF clones in mouse, rat for EIF1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: EIF1 (NM_001412)
    Sino Biological Human cDNA Clone for EIF1
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for EIF1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat EIF1

    Cell Line
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    GenScript Custom overexpressing Cell Line Services for EIF1
    Browse ESI BIO Cell Lines and PureStem Progenitors for EIF1 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for EIF1


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol2
    nucleus2
    peroxisome1

    Gene Ontology (GO): 1 cellular component term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm TAS10347211

    Find genes that share ontologies with EIF1           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for EIF1 About    
    See pathways by source

    SuperPathContained pathways About
    1Translational Control
    Translational Control
    2Translation Factors
    Translation Factors
    3RNA transport
    RNA transport


    Find genes that share SuperPaths with EIF1           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    2 Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for EIF1
        eIF2 Pathway
    Insulin Receptor Pathway

    1 Cell Signaling Technology (CST) Pathway for EIF1
        Translational Control

    1 BioSystems Pathway for EIF1
        Translation Factors



    1 Kegg Pathway  (Kegg details for EIF1):
        RNA transport

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for EIF1
    Interactions:

        Search GeneGlobe Interaction Network for EIF1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for EIF1 (P415672, 3 ENSP000004194494) via UniProtKB, MINT, STRING, and/or I2D (see all 174)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    OLFM2O958972, 3MINT-63323 I2D: score=3 
    MAPK6Q166592, 3MINT-8261054 I2D: score=2 
    RASA1P209362, 3, ENSP000002743764MINT-8268207 I2D: score=2 STRING: ENSP00000274376
    EIF3CQ996133, ENSP000003326044I2D: score=8 STRING: ENSP00000332604
    EIF3BP558843, ENSP000003541254I2D: score=7 STRING: ENSP00000354125
    About this table

    Gene Ontology (GO): 4 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006413translational initiation ----
    GO:0006446regulation of translational initiation TAS10347211
    GO:0006950response to stress NAS10347211
    GO:0009048dosage compensation by inactivation of X chromosome IEA--

    Find genes that share ontologies with EIF1           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for EIF1

    2 Novoseek inferred chemical compound relationships for EIF1 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    gtp 62.4 17 15601822 (5), 10659855 (1), 16362046 (1), 18593708 (1) (see all 6)
    trna 55.9 5 17956730 (2), 16362046 (1), 17434125 (1)



    Find genes that share compounds with EIF1           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for EIF1 gene: 
    NM_005801.3  

    Unigene Cluster for EIF1:

    Eukaryotic translation initiation factor 1
    Hs.150580  [show with all ESTs]
    Unigene Representative Sequence: BQ278455
    7 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000462917(uc002hxj.3 uc002hxk.3) ENST00000591776 ENST00000469257
    ENST00000482111 ENST00000310837 ENST00000469308 ENST00000586699
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat EIF1 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate EIF1 (see all 25):
    hsa-miR-623 hsa-miR-323-3p hsa-miR-4317 hsa-miR-100* hsa-miR-4328 hsa-miR-300 hsa-miR-522 hsa-miR-570
    SwitchGear 3'UTR luciferase reporter plasmidEIF1 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for EIF1
    Predesigned siRNA for gene silencing in human, mouse, rat EIF1
    Clone
    Products:
         
    OriGene clones in human, mouse for EIF1 (see all 6)
    OriGene ORF clones in mouse, rat for EIF1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: EIF1 (NM_001412)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for EIF1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat EIF1
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for EIF1
    OriGene qSTAR qPCR primer pairs in human, mouse for EIF1
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat EIF1
      QuantiTect SYBR Green Assays in human, mouse, rat EIF1
      QuantiFast Probe-based Assays in human, mouse, rat EIF1

    Additional mRNA sequence: 

    AF083441.1 AF100737.1 AJ012375.1 AK311209.1 AK311862.1 BC005118.1 BC008710.1 BT006645.1 
    CR457051.1 L26247.1 

    Selected DOTS entries (see all 54):

    DT.87017930  DT.97857707  DT.87000962  DT.100060625  DT.100688807  DT.91769712  DT.100688802  DT.95170862 
    DT.91932427  DT.40124100  DT.95170828  DT.100688801  DT.95170729  DT.121022158  DT.92379834  DT.120959094 
    DT.120959090  DT.120959114  DT.100688811  DT.100866432  DT.120959199  DT.97852514  DT.97852539  DT.100688792 

    Selected AceView cDNA sequences (see all 2215):

    BX393183 CB306418 N40037 W42679 AF074649 AW090809 CD107610 AA384528 
    F24673 AA187652 BU170599 BQ677399 W67411 T34700 AI630668 AA296091 
    BQ222358 BM091452 CR595398 BM829971 AI832689 F03160 AI160330 BU838757 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for EIF1 (see all 6)    About this scheme

    ExUns: 1a · 1b · 1c · 1d · 1e ^ 2a · 2b ^ 3a · 3b ^ 4a · 4b · 4c · 4d · 4e
    SP1:                          -     -                                                   
    SP2:                          -     -                                                   
    SP3:                          -     -     -                                             
    SP4:                          -     -                                                   
    SP5:                                -                                                   


    ECgene alternative splicing isoforms for EIF1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    EIF1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CAATAAACTG
    EIF1 Expression
    About this image

    EIF1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    EIF1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.150580
        Custom PCR Arrays for EIF1
    Primer
    Products:
    OriGene qPCR primer pairs and template standards for EIF1
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    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat EIF1
    QuantiTect SYBR Green Assays in human, mouse, rat EIF1
    QuantiFast Probe-based Assays in human, mouse, rat EIF1
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for EIF1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of eukaryotes.

    Orthologs for EIF1 gene from Selected species (see all 20)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Eif15 eukaryotic translation initiation factor 1   --   11 (63.46 cM) 100319885 
    chicken
    (Gallus gallus)
    Aves EIF11 eukaryotic translation initiation factor 1 89.68(n)
    98.23(a)
      420037  NM_001167735.1  NP_001161207.1 
    lizard
    (Anolis carolinensis)
    Reptilia EIF16
    eukaryotic translation initiation factor 1
    99(a)
    1 ↔ 1
    6(70956314-70962904)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia eif11 eukaryotic translation initiation factor 1 77.88(n)
    86.73(a)
      448694  NM_001005114.1  NP_001005114.1 
    zebrafish
    (Danio rerio)
    Actinopterygii wufb54a122 wufb54a12 82.2(n)   322237  AY398352.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG177376
    --
    71(a)
    1 → many
    3L(3223341-3224650)
    worm
    (Caenorhabditis elegans)
    Secernentea eif-16
    Protein EIF-1 (eif-1) mRNA, complete cds
    52(a)
    1 → many
    II(4990831-4993580) WBGene00020868
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes SUI16
    Translation initiation factor eIF1; component of a...
    61(a)
    1 → many
    XIV(187170-187496) YNL244C
    soybean
    (Glycine max)
    eudicotyledons 445176982   -- 73.36(n)  
    barley
    (Hordeum vulgare)
    Liliopsida AJ476519.12   -- 72.3(n)    AJ476519.1 


    ENSEMBL Gene Tree for EIF1 (if available)
    TreeFam Gene Tree for EIF1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for EIF1 gene
    EIF1B2  
    3 SIMAP similar genes for EIF1 using alignment to 3 protein entries:     EIF1_HUMAN (see all proteins):
    SUI1    EIF1B    GC20

    Find genes that share paralogs with EIF1           About GenesLikeMe


    Selected Pseudogenes.org Pseudogenes for EIF1 (see all 7)
    PGOHUM00000248699 PGOHUM00000236978 PGOHUM00000234120 PGOHUM00000243973 PGOHUM00000245114


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for EIF1 (see all 152)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 17 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs571537921,2
    C,F--39843198(+) CAGCCA/GGAATG 1 -- us2k13Minor allele frequency- G:0.21WA CSA 122
    rs1857116441,2
    --39843287(+) TTGGCA/GCCTCT 1 -- us2k10--------
    rs596414681,2
    --39843370(+) ATGGCA/GCCATC 1 -- us2k10--------
    rs1893146831,2
    --39843401(+) CTTCCC/TGGGTT 1 -- us2k10--------
    rs556675601,2
    C,F--39843411(+) TCAAAT/CAATTA 1 -- us2k13Minor allele frequency- C:0.21WA CSA 122
    rs1389291681,2
    --39843434(+) CTCCCA/GAGTAG 1 -- us2k10--------
    rs1819057011,2
    C--39843457(+) GCACAC/TGCCAC 1 -- us2k10--------
    rs1159279111,2
    C,F--39843601(+) ACAGCG/ACCCAG 1 -- us2k11Minor allele frequency- A:0.03WA 118
    rs1854897971,2
    --39843633(+) TTAGTC/GGCTCT 1 -- us2k10--------
    rs1172945551,2
    C,F--39843645(+) TCTCCC/TGCTGG 1 -- us2k11Minor allele frequency- T:0.01NA 120

    HapMap Linkage Disequilibrium report for EIF1 (39845127 - 39848920 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for EIF1:    About this table    
    Variant IDTypeSubtypePubMed ID
    dgv962e1CNV Complex17122850
    dgv961e1CNV Complex17122850

    Site Specific Mutation Identification with PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 400014    OMIM disorders: --


    Find genes that share disorders with EIF1           About GenesLikeMe


    Export disorders for EIF1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for EIF1 gene, integrated from 10 sources (see all 48):
    (articles sorted by number of sources associating them with EIF1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Cloning and characterization of a human genotoxic and endoplasmic reticulum stress-inducible cDNA that encodes translation initiation factor 1 (eIF1(A121/SUI1)). (PubMed id 10347211)1, 2, 3 Sheikh M.S.... Fornace A.J. Jr. (J. Biol. Chem. 1999)
    2. Expressed sequence tags identify a human isolog of the suil translation initiation factor. (PubMed id 7904817)1, 2, 3 Fields C.A. and Adams M.D. (Biochem. Biophys. Res. Commun. 1994)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    4. Novel Upf2p orthologues suggest a functional link between translation initiation and nonsense surveillance complexes. (PubMed id 11073994)1, 2 Mendell J.T.... Dietz H.C. (Mol. Cell. Biol. 2000)
    5. Structure and interactions of the translation initiation factor eIF1. (PubMed id 10228174)1, 2 Fletcher C.M.... Wagner G. (EMBO J. 1999)
    6. Coordinated movements of eukaryotic translation initiation factors eIF1, eIF1A, and eIF5 trigger phosphate release from eIF2 in response to start codon recognition by the ribosomal preinitiation complex. (PubMed id 23293029)1 Nanda J.S....Lorsch J.R. (J. Biol. Chem. 2013)
    7. Pathway Analysis of ChIP-Seq-Based NRF1 Target Genes Suggests a Logical Hypothesis of their Involvement in the Pathogenesis of Neurodegenerative Diseases. (PubMed id 24250222)1 Satoh J....Yamamoto Y. (Gene Regul Syst Bio 2013)
    8. A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (Cell 2012)
    9. Methods for quantification of in vivo changes in protein ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724)1 Udeshi N.D....Carr S.A. (amp 2012)
    10. Proteome-wide identification of ubiquitylation sites by conjugation of engineered lysine-less ubiquitin. (PubMed id 22053931)1 Oshikawa K....Nakayama K.I. (J. Proteome Res. 2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
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    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 10209 HGNC: 3249 AceView: SUI1 Ensembl:ENSG00000173812 euGenes: HUgn10209
    ECgene: EIF1 Kegg: 10209 H-InvDB: EIF1

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for EIF1 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for EIF1 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for EIF1 gene:
    Search GeneIP for patents involving EIF1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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