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Aliases for EID3 Gene

Aliases for EID3 Gene

  • EP300 Interacting Inhibitor Of Differentiation 3 2 3 5
  • Non-Structural Maintenance Of Chromosomes Element 4 Homolog B 3 4
  • EID-1-Like Inhibitor Of Differentiation 3 3 4
  • E1A-Like Inhibitor Of Differentiation 3 3 4
  • Non-SMC Element 4 Homolog B 3 4
  • EID-3 3 4
  • NS4EB 3 4
  • Testis Tissue Sperm-Binding Protein Li 96mP 3
  • NSMCE4B 3
  • NSE4B 3

External Ids for EID3 Gene

Previous GeneCards Identifiers for EID3 Gene

  • GC12U900507
  • GC12P103221
  • GC12P104697

Summaries for EID3 Gene

GeneCards Summary for EID3 Gene

EID3 (EP300 Interacting Inhibitor Of Differentiation 3) is a Protein Coding gene. Among its related pathways are Transport to the Golgi and subsequent modification and SUMOylation. GO annotations related to this gene include identical protein binding. An important paralog of this gene is NSMCE4A.

UniProtKB/Swiss-Prot for EID3 Gene

  • Tissue-specific component of the SMC5-SMC6 complex, a complex involved in repair of DNA double-strand breaks by homologous recombination. The complex may promote sister chromatid homologous recombination by recruiting the SMC1-SMC3 cohesin complex to double-strand breaks. The complex is required for telomere maintenance via recombination and mediates sumoylation of shelterin complex (telosome) components.

  • Acts as a repressor of nuclear receptor-dependent transcription possibly by interfering with CREBBP-dependent coactivation. May function as a coinhibitor of other CREBBP/EP300-dependent transcription factors.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for EID3 Gene

Genomics for EID3 Gene

Regulatory Elements for EID3 Gene

Enhancers for EID3 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around EID3 on UCSC Golden Path with GeneCards custom track

Promoters for EID3 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around EID3 on UCSC Golden Path with GeneCards custom track

Genomic Location for EID3 Gene

Chromosome:
12
Start:
104,303,732 bp from pter
End:
104,305,205 bp from pter
Size:
1,474 bases
Orientation:
Plus strand

Genomic View for EID3 Gene

Genes around EID3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
EID3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for EID3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for EID3 Gene

Proteins for EID3 Gene

  • Protein details for EID3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8N140-EID3_HUMAN
    Recommended name:
    EP300-interacting inhibitor of differentiation 3
    Protein Accession:
    Q8N140

    Protein attributes for EID3 Gene

    Size:
    333 amino acids
    Molecular mass:
    38168 Da
    Quaternary structure:
    • Component of the SMC5-SMC6 complex which consists at least of SMC5, SMC6, NSMCE2, NSMCE1, NSMCE4A or EID3 and NSMCE3; EID3 seems to be a testis-specific subunit. NSMCE1, NSMCE4A or EID3 and NSMCE3 probably form a subcomplex that bridges the head domains of the SMC5:SMC6 heterodimer. Homodimer, and heterodimer with EID2 (By similarity). Interacts with the C-terminal region of CREBBP.

neXtProt entry for EID3 Gene

Proteomics data for EID3 Gene at MOPED

Post-translational modifications for EID3 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for EID3 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for EID3 Gene

Domains & Families for EID3 Gene

Protein Domains for EID3 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for EID3 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8N140

UniProtKB/Swiss-Prot:

EID3_HUMAN :
  • Belongs to the NSE4 family.
Family:
  • Belongs to the NSE4 family.
genes like me logo Genes that share domains with EID3: view

No data available for Gene Families for EID3 Gene

Function for EID3 Gene

Molecular function for EID3 Gene

UniProtKB/Swiss-Prot Function:
Tissue-specific component of the SMC5-SMC6 complex, a complex involved in repair of DNA double-strand breaks by homologous recombination. The complex may promote sister chromatid homologous recombination by recruiting the SMC1-SMC3 cohesin complex to double-strand breaks. The complex is required for telomere maintenance via recombination and mediates sumoylation of shelterin complex (telosome) components.
UniProtKB/Swiss-Prot Function:
Acts as a repressor of nuclear receptor-dependent transcription possibly by interfering with CREBBP-dependent coactivation. May function as a coinhibitor of other CREBBP/EP300-dependent transcription factors.

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for EID3 Gene

Localization for EID3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for EID3 Gene

Nucleus. Cytoplasm. Chromosome, telomere. Note=May shuttle between nucleus and cytoplasm. {ECO:0000269 PubMed:15987788}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for EID3 Gene COMPARTMENTS Subcellular localization image for EID3 gene
Compartment Confidence
nucleus 4

Gene Ontology (GO) - Cellular Components for EID3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000781 chromosome, telomeric region IEA --
GO:0005737 cytoplasm IEA --
genes like me logo Genes that share ontologies with EID3: view

Pathways & Interactions for EID3 Gene

genes like me logo Genes that share pathways with EID3: view

Gene Ontology (GO) - Biological Process for EID3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006310 DNA recombination IEA --
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0016925 protein sumoylation TAS --
genes like me logo Genes that share ontologies with EID3: view

No data available for SIGNOR curated interactions for EID3 Gene

Drugs & Compounds for EID3 Gene

No Compound Related Data Available

Transcripts for EID3 Gene

mRNA/cDNA for EID3 Gene

(1) REFSEQ mRNAs :
(2) Additional mRNA sequences :
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for EID3 Gene

EP300 interacting inhibitor of differentiation 3:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for EID3 Gene

No ASD Table

Relevant External Links for EID3 Gene

GeneLoc Exon Structure for
EID3
ECgene alternative splicing isoforms for
EID3

Expression for EID3 Gene

mRNA expression in normal human tissues for EID3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for EID3 Gene

This gene is overexpressed in Testis (x15.9).

Protein differential expression in normal tissues from HIPED for EID3 Gene

This gene is overexpressed in Monocytes (39.3) and Lung (25.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for EID3 Gene



SOURCE GeneReport for Unigene cluster for EID3 Gene Hs.659857

mRNA Expression by UniProt/SwissProt for EID3 Gene

Q8N140-EID3_HUMAN
Tissue specificity: Highly expressed in testis.
genes like me logo Genes that share expression patterns with EID3: view

Protein tissue co-expression partners for EID3 Gene

Primer Products

In Situ Assay Products

Orthologs for EID3 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for EID3 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia EID3 35
  • 83.65 (n)
  • 79.87 (a)
dog
(Canis familiaris)
Mammalia EID3 35
  • 86.07 (n)
  • 81.42 (a)
mouse
(Mus musculus)
Mammalia Eid3 35
  • 77.43 (n)
  • 72.73 (a)
Eid3 16
chimpanzee
(Pan troglodytes)
Mammalia EID3 35
  • 99.1 (n)
  • 97.6 (a)
rat
(Rattus norvegicus)
Mammalia Eid3 35
  • 79.73 (n)
  • 76.18 (a)
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 44 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 55 (a)
OneToMany
chicken
(Gallus gallus)
Aves -- 36
  • 40 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 42 (a)
OneToMany
zebrafish
(Danio rerio)
Actinopterygii nsmce4a 36
  • 40 (a)
OneToMany
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes nse4 35
  • 41.61 (n)
  • 29.2 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 27 (a)
OneToMany
Species with no ortholog for EID3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for EID3 Gene

ENSEMBL:
Gene Tree for EID3 (if available)
TreeFam:
Gene Tree for EID3 (if available)

Paralogs for EID3 Gene

Paralogs for EID3 Gene

(1) SIMAP similar genes for EID3 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with EID3: view

Variants for EID3 Gene

Structural Variations from Database of Genomic Variants (DGV) for EID3 Gene

Variant ID Type Subtype PubMed ID
nsv899493 CNV Gain 21882294
nsv899494 CNV Gain 21882294
nsv52994 CNV Loss 16902084

Variation tolerance for EID3 Gene

Residual Variation Intolerance Score: 65.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.05; 37.70% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for EID3 Gene

HapMap Linkage Disequilibrium report
EID3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations from dbSNP and Humsavar for EID3 Gene

Disorders for EID3 Gene

Relevant External Links for EID3

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
EID3

No disorders were found for EID3 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for EID3 Gene

Publications for EID3 Gene

  1. EID3 is a novel EID family member and an inhibitor of CBP-dependent co-activation. (PMID: 15987788) Bavner A. … Treuter E. (Nucleic Acids Res. 2005) 2 3 4 67
  2. Qri2/Nse4, a component of the essential Smc5/6 DNA repair complex. (PMID: 15752197) Hu B. … Panaretou B. (Mol. Microbiol. 2005) 2 3
  3. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  4. Citalopram and escitalopram plasma drug and metabolite concentrations: genome-wide associations. (PMID: 24528284) Ji Y. … Weinshilboum R.M. (Br J Clin Pharmacol 2014) 3
  5. The F-box protein FBXO25 promotes the proteasome-dependent degradation of ELK-1 protein. (PMID: 23940030) Teixeira F.R. … Gomes M.D. (J. Biol. Chem. 2013) 3

Products for EID3 Gene

Sources for EID3 Gene

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