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Aliases for EID3 Gene

Aliases for EID3 Gene

  • EP300 Interacting Inhibitor Of Differentiation 3 2 3 5
  • Non-Structural Maintenance Of Chromosomes Element 4 Homolog B 3 4
  • EID-1-Like Inhibitor Of Differentiation 3 3 4
  • E1A-Like Inhibitor Of Differentiation 3 3 4
  • Non-SMC Element 4 Homolog B 3 4
  • EID-3 3 4
  • NS4EB 3 4
  • EP300-Interacting Inhibitor Of Differentiation 3 3
  • Testis Tissue Sperm-Binding Protein Li 96mP 3
  • NSMCE4B 3
  • NSE4B 3

External Ids for EID3 Gene

Previous GeneCards Identifiers for EID3 Gene

  • GC12U900507
  • GC12P103221
  • GC12P104697

Summaries for EID3 Gene

GeneCards Summary for EID3 Gene

EID3 (EP300 Interacting Inhibitor Of Differentiation 3) is a Protein Coding gene. Among its related pathways are Metabolism of proteins and SUMOylation. GO annotations related to this gene include identical protein binding. An important paralog of this gene is NSMCE4A.

UniProtKB/Swiss-Prot for EID3 Gene

  • Tissue-specific component of the SMC5-SMC6 complex, a complex involved in repair of DNA double-strand breaks by homologous recombination. The complex may promote sister chromatid homologous recombination by recruiting the SMC1-SMC3 cohesin complex to double-strand breaks. The complex is required for telomere maintenance via recombination and mediates sumoylation of shelterin complex (telosome) components.

  • Acts as a repressor of nuclear receptor-dependent transcription possibly by interfering with CREBBP-dependent coactivation. May function as a coinhibitor of other CREBBP/EP300-dependent transcription factors.

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for EID3 Gene

Genomics for EID3 Gene

Regulatory Elements for EID3 Gene

Enhancers for EID3 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH12G104283 1.4 ENCODE dbSUPER 43.7 -16.4 -16396 6.7 MLX CREB3L1 ZFP64 FEZF1 DMAP1 YY1 SLC30A9 ZNF143 ZNF263 SP3 EID3 WASHC4 APPL2 ENSG00000257732
GH12G104302 1 ENCODE dbSUPER 45.5 +0.1 97 2.2 HDGF MXI1 NFIB BACH1 MAX SIN3A RBBP5 CHD7 POLR2A CREM EID3 GC12P104350 PIR31122
GH12G104295 1 ENCODE dbSUPER 44.3 -7.9 -7921 2.6 BCOR CTCF FOXA2 ZMYM3 SIN3A CHD7 ZNF664 ZNF121 CTBP1 GATA3 EID3 ENSG00000257732
GH12G104275 1.9 FANTOM5 Ensembl ENCODE dbSUPER 15.3 -26.6 -26632 2.6 HDGF PKNOX1 FOXA2 SIN3A FEZF1 YY1 FOS DEK ZNF263 JUNB EID3 WASHC4 RPL18AP3 ENSG00000257681 TXNRD1 ENSG00000257732 GC12P104268
GH12G104262 1.1 Ensembl ENCODE dbSUPER 19.6 -39.9 -39916 2.0 GATA3 JUND ZNF687 HLF SIN3A FOXP2 ZIC2 EID3 RPL18AP3 TXNRD1
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around EID3 on UCSC Golden Path with GeneCards custom track

Promoters for EID3 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000056527 -32 601 CTCF HDGF MXI1 BACH1 MAX SIN3A RBBP5 CHD7 POLR2A CREM

Genomic Location for EID3 Gene

Chromosome:
12
Start:
104,303,732 bp from pter
End:
104,305,205 bp from pter
Size:
1,474 bases
Orientation:
Plus strand

Genomic View for EID3 Gene

Genes around EID3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
EID3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for EID3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for EID3 Gene

Proteins for EID3 Gene

  • Protein details for EID3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8N140-EID3_HUMAN
    Recommended name:
    EP300-interacting inhibitor of differentiation 3
    Protein Accession:
    Q8N140

    Protein attributes for EID3 Gene

    Size:
    333 amino acids
    Molecular mass:
    38168 Da
    Quaternary structure:
    • Component of the SMC5-SMC6 complex which consists at least of SMC5, SMC6, NSMCE2, NSMCE1, NSMCE4A or EID3 and NSMCE3; EID3 seems to be a testis-specific subunit. NSMCE1, NSMCE4A or EID3 and NSMCE3 probably form a subcomplex that bridges the head domains of the SMC5:SMC6 heterodimer. Homodimer, and heterodimer with EID2 (By similarity). Interacts with the C-terminal region of CREBBP.

neXtProt entry for EID3 Gene

Post-translational modifications for EID3 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for EID3 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for EID3 Gene

Domains & Families for EID3 Gene

Protein Domains for EID3 Gene

Suggested Antigen Peptide Sequences for EID3 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8N140

UniProtKB/Swiss-Prot:

EID3_HUMAN :
  • Belongs to the NSE4 family.
Family:
  • Belongs to the NSE4 family.
genes like me logo Genes that share domains with EID3: view

No data available for Gene Families for EID3 Gene

Function for EID3 Gene

Molecular function for EID3 Gene

UniProtKB/Swiss-Prot Function:
Tissue-specific component of the SMC5-SMC6 complex, a complex involved in repair of DNA double-strand breaks by homologous recombination. The complex may promote sister chromatid homologous recombination by recruiting the SMC1-SMC3 cohesin complex to double-strand breaks. The complex is required for telomere maintenance via recombination and mediates sumoylation of shelterin complex (telosome) components.
UniProtKB/Swiss-Prot Function:
Acts as a repressor of nuclear receptor-dependent transcription possibly by interfering with CREBBP-dependent coactivation. May function as a coinhibitor of other CREBBP/EP300-dependent transcription factors.

Gene Ontology (GO) - Molecular Function for EID3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 15970276
GO:0042802 identical protein binding IPI 15970276
genes like me logo Genes that share ontologies with EID3: view

Animal Model Products

Inhibitory RNA Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for EID3 Gene

Localization for EID3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for EID3 Gene

Nucleus. Cytoplasm. Chromosome, telomere. Note=May shuttle between nucleus and cytoplasm. {ECO:0000269 PubMed:15987788}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for EID3 gene
Compartment Confidence
nucleus 4

Gene Ontology (GO) - Cellular Components for EID3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000781 chromosome, telomeric region IEA --
GO:0005634 nucleus IDA --
GO:0005654 nucleoplasm TAS --
GO:0005694 chromosome IEA --
GO:0005730 nucleolus IDA --
genes like me logo Genes that share ontologies with EID3: view

Pathways & Interactions for EID3 Gene

genes like me logo Genes that share pathways with EID3: view

Gene Ontology (GO) - Biological Process for EID3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006281 DNA repair IEA --
GO:0006310 DNA recombination IEA --
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0006974 cellular response to DNA damage stimulus IEA --
genes like me logo Genes that share ontologies with EID3: view

No data available for SIGNOR curated interactions for EID3 Gene

Drugs & Compounds for EID3 Gene

No Compound Related Data Available

Transcripts for EID3 Gene

mRNA/cDNA for EID3 Gene

(1) REFSEQ mRNAs :
(2) Additional mRNA sequences :
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for EID3 Gene

EP300 interacting inhibitor of differentiation 3:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for EID3 Gene

No ASD Table

Relevant External Links for EID3 Gene

GeneLoc Exon Structure for
EID3
ECgene alternative splicing isoforms for
EID3

Expression for EID3 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for EID3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for EID3 Gene

This gene is overexpressed in Testis (x15.9).

Protein differential expression in normal tissues from HIPED for EID3 Gene

This gene is overexpressed in Monocytes (39.3) and Lung (25.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for EID3 Gene



Protein tissue co-expression partners for EID3 Gene

NURSA nuclear receptor signaling pathways regulating expression of EID3 Gene:

EID3

SOURCE GeneReport for Unigene cluster for EID3 Gene:

Hs.659857

mRNA Expression by UniProt/SwissProt for EID3 Gene:

Q8N140-EID3_HUMAN
Tissue specificity: Highly expressed in testis.
genes like me logo Genes that share expression patterns with EID3: view

Primer Products

No data available for Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for EID3 Gene

Orthologs for EID3 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for EID3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia EID3 34
  • 99.1 (n)
dog
(Canis familiaris)
Mammalia EID3 34
  • 86.07 (n)
cow
(Bos Taurus)
Mammalia EID3 34
  • 83.65 (n)
rat
(Rattus norvegicus)
Mammalia Eid3 34
  • 79.73 (n)
mouse
(Mus musculus)
Mammalia Eid3 34 16
  • 77.43 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 55 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia -- 35
  • 44 (a)
OneToMany
chicken
(Gallus gallus)
Aves -- 35
  • 40 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 35
  • 42 (a)
OneToMany
zebrafish
(Danio rerio)
Actinopterygii nsmce4a 35
  • 40 (a)
OneToMany
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes nse4 34
  • 41.61 (n)
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 27 (a)
OneToMany
Species where no ortholog for EID3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for EID3 Gene

ENSEMBL:
Gene Tree for EID3 (if available)
TreeFam:
Gene Tree for EID3 (if available)

Paralogs for EID3 Gene

Paralogs for EID3 Gene

(1) SIMAP similar genes for EID3 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with EID3: view

Variants for EID3 Gene

Sequence variations from dbSNP and Humsavar for EID3 Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type
rs1000106768 -- 104,303,449(+) AGCGT(G/T)TTAAA intron-variant, upstream-variant-2KB
rs1000293297 -- 104,302,742(+) CCTCG(G/T)CCTCC intron-variant, upstream-variant-2KB
rs1002688695 -- 104,303,027(+) TGGCC(-/T)TTAGC intron-variant, upstream-variant-2KB
rs1003058269 -- 104,301,911(+) CAGTG(G/T)GTAGG intron-variant, upstream-variant-2KB
rs1003631224 -- 104,305,228(+) ATTTG(C/T)AAAAC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for EID3 Gene

Variant ID Type Subtype PubMed ID
esv3580448 CNV loss 25503493
esv3630634 CNV gain 21293372
nsv52994 CNV deletion 16902084

Variation tolerance for EID3 Gene

Residual Variation Intolerance Score: 65.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.05; 37.70% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for EID3 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
EID3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for EID3 Gene

Disorders for EID3 Gene

Relevant External Links for EID3

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
EID3

No disorders were found for EID3 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for EID3 Gene

Publications for EID3 Gene

  1. EID3 is a novel EID family member and an inhibitor of CBP-dependent co-activation. (PMID: 15987788) Bavner A. … Treuter E. (Nucleic Acids Res. 2005) 2 3 4 64
  2. Interactions between the Nse3 and Nse4 components of the SMC5-6 complex identify evolutionarily conserved interactions between MAGE and EID Families. (PMID: 21364888) Hudson J.J. … Palecek J. (PLoS ONE 2011) 3 4 64
  3. Identification of the proteins, including MAGEG1, that make up the human SMC5-6 protein complex. (PMID: 18086888) Taylor E.M. … Lehmann A.R. (Mol. Cell. Biol. 2008) 3 4 64
  4. Qri2/Nse4, a component of the essential Smc5/6 DNA repair complex. (PMID: 15752197) Hu B. … Panaretou B. (Mol. Microbiol. 2005) 2 3 64
  5. The melanoma-associated antigen 1 (MAGEA1) protein stimulates the E3 ubiquitin-ligase activity of TRIM31 within a TRIM31-MAGEA1-NSE4 complex. (PMID: 25590999) Kozakova L. … Palecek J.J. (Cell Cycle 2015) 3 64

Products for EID3 Gene

Sources for EID3 Gene

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