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Aliases for EID2B Gene

Aliases for EID2B Gene

  • EP300 Interacting Inhibitor Of Differentiation 2B 2 3 5
  • EID-2B 3 4
  • EID-3 3 4
  • EID-2-Like Inhibitor Of Differentiation-3 3
  • EID-2-Like Inhibitor Of Differentiation 3 4
  • EID3 4

External Ids for EID2B Gene

Previous GeneCards Identifiers for EID2B Gene

  • GC19M044715
  • GC19M040021
  • GC19M036467

Summaries for EID2B Gene

GeneCards Summary for EID2B Gene

EID2B (EP300 Interacting Inhibitor Of Differentiation 2B) is a Protein Coding gene. Among its related pathways are Transport to the Golgi and subsequent modification and SUMOylation. An important paralog of this gene is EID2.

UniProtKB/Swiss-Prot for EID2B Gene

  • Acts as a repressor of MYOD-dependent transcription, glucocorticoid receptor-dependent transcription, and muscle differentiation.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for EID2B Gene

Genomics for EID2B Gene

Regulatory Elements for EID2B Gene

Promoters for EID2B Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around EID2B on UCSC Golden Path with GeneCards custom track

Genomic Location for EID2B Gene

Chromosome:
19
Start:
39,530,990 bp from pter
End:
39,532,867 bp from pter
Size:
1,878 bases
Orientation:
Minus strand

Genomic View for EID2B Gene

Genes around EID2B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
EID2B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for EID2B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for EID2B Gene

Proteins for EID2B Gene

  • Protein details for EID2B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96D98-EID2B_HUMAN
    Recommended name:
    EP300-interacting inhibitor of differentiation 2B
    Protein Accession:
    Q96D98
    Secondary Accessions:
    • Q8N8S0

    Protein attributes for EID2B Gene

    Size:
    161 amino acids
    Molecular mass:
    16985 Da
    Quaternary structure:
    • Homodimer and heterodimer with EID2. Interacts with HDAC1 and HDAC2.

neXtProt entry for EID2B Gene

Proteomics data for EID2B Gene at MOPED

Post-translational modifications for EID2B Gene

No Post-translational modifications

Other Protein References for EID2B Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for EID2B Gene

Domains & Families for EID2B Gene

Protein Domains for EID2B Gene

ProtoNet:

Suggested Antigen Peptide Sequences for EID2B Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q96D98

UniProtKB/Swiss-Prot:

EID2B_HUMAN :
  • The C-terminal portion of EID2B is required for nuclear localization.
Domain:
  • The C-terminal portion of EID2B is required for nuclear localization.
genes like me logo Genes that share domains with EID2B: view

No data available for Gene Families for EID2B Gene

Function for EID2B Gene

Molecular function for EID2B Gene

UniProtKB/Swiss-Prot Function:
Acts as a repressor of MYOD-dependent transcription, glucocorticoid receptor-dependent transcription, and muscle differentiation.
genes like me logo Genes that share phenotypes with EID2B: view

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for EID2B Gene

Localization for EID2B Gene

Subcellular locations from UniProtKB/Swiss-Prot for EID2B Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for EID2B Gene COMPARTMENTS Subcellular localization image for EID2B gene
Compartment Confidence
nucleus 4
cytosol 2
extracellular 1

No data available for Gene Ontology (GO) - Cellular Components for EID2B Gene

Pathways & Interactions for EID2B Gene

genes like me logo Genes that share pathways with EID2B: view

Interacting Proteins for EID2B Gene

Gene Ontology (GO) - Biological Process for EID2B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0007517 muscle organ development IEA --
GO:0030154 cell differentiation IEA --
genes like me logo Genes that share ontologies with EID2B: view

No data available for SIGNOR curated interactions for EID2B Gene

Drugs & Compounds for EID2B Gene

No Compound Related Data Available

Transcripts for EID2B Gene

mRNA/cDNA for EID2B Gene

(1) REFSEQ mRNAs :
(4) Additional mRNA sequences :
(23) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for EID2B Gene

EP300 interacting inhibitor of differentiation 2B:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for EID2B Gene

No ASD Table

Relevant External Links for EID2B Gene

GeneLoc Exon Structure for
EID2B
ECgene alternative splicing isoforms for
EID2B

Expression for EID2B Gene

mRNA expression in normal human tissues for EID2B Gene

Protein differential expression in normal tissues from HIPED for EID2B Gene

This gene is overexpressed in Platelet (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for EID2B Gene



SOURCE GeneReport for Unigene cluster for EID2B Gene Hs.135181

genes like me logo Genes that share expression patterns with EID2B: view

Protein tissue co-expression partners for EID2B Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for EID2B Gene

Orthologs for EID2B Gene

This gene was present in the common ancestor of human and mouse.

Orthologs for EID2B Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia EID2B 35
  • 99.17 (n)
  • 99.38 (a)
EID2B 36
  • 99 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Eid2b 16
Eid2b 36
  • 55 (a)
OneToOne
Eid2b 35
  • 68.43 (n)
  • 54.97 (a)
rat
(Rattus norvegicus)
Mammalia Eid2b 35
  • 69.09 (n)
  • 58.94 (a)
Species with no ortholog for EID2B:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for EID2B Gene

ENSEMBL:
Gene Tree for EID2B (if available)
TreeFam:
Gene Tree for EID2B (if available)

Paralogs for EID2B Gene

Paralogs for EID2B Gene

genes like me logo Genes that share paralogs with EID2B: view

Variants for EID2B Gene

Sequence variations from dbSNP and Humsavar for EID2B Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
rs1123301 -- 39,532,668(+) TCCCG(A/G)GCCTC reference, synonymous-codon
rs1368468 -- 39,533,684(+) tttta(C/T)tgggg upstream-variant-2KB
rs1368469 -- 39,533,724(+) catcg(A/C/T)ccatt upstream-variant-2KB
rs3082162 -- 39,533,857(+) AAGTC(-/TA)TGTTC upstream-variant-2KB
rs5828041 -- 39,533,858(+) AGTCT(-/AT)GTTCC upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for EID2B Gene

Variant ID Type Subtype PubMed ID
dgv3863n71 CNV Loss 21882294
dgv3864n71 CNV Loss 21882294
nsv911694 CNV Loss 21882294
nsv137930 CNV Loss 16902084

Variation tolerance for EID2B Gene

Residual Variation Intolerance Score: 63.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.54; 11.78% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for EID2B Gene

HapMap Linkage Disequilibrium report
EID2B

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for EID2B Gene

Disorders for EID2B Gene

Relevant External Links for EID2B

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
EID2B

No disorders were found for EID2B Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for EID2B Gene

Publications for EID2B Gene

  1. A novel EID family member, EID-3, inhibits differentiation and forms a homodimer or heterodimer with EID-2. (PMID: 15970276) Sasajima Y. … Yuasa Y. (Biochem. Biophys. Res. Commun. 2005) 2 3 4 67
  2. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  3. Interactions between the Nse3 and Nse4 components of the SMC5-6 complex identify evolutionarily conserved interactions between MAGE and EID Families. (PMID: 21364888) Hudson J.J. … Palecek J. (PLoS ONE 2011) 3
  4. A human protein-protein interaction network: a resource for annotating the proteome. (PMID: 16169070) Stelzl U. … Wanker E.E. (Cell 2005) 3
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3

Products for EID2B Gene

Sources for EID2B Gene

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