EID2B Gene
protein-coding GIFtS: 37
GCID: GC19M040021
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EP300 interacting inhibitor of differentiation 2B
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Aliases
for EID2B gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| EP300 Interacting Inhibitor Of Differentiation 2B1 2 | | FLJ389441 | | EID-31 2 3 | | EID-2-Like Inhibitor Of Differentiation-32 | | EID-2B2 3 | | EP300-Interacting Inhibitor Of Differentiation 2B2 | | EID-2-Like Inhibitor Of Differentiation 32 3 | | EID33 |
Export aliases for EID2B gene to outside databasesPrevious GC identifers: GC19M044715 GC19M036467 |
Summaries
for EID2B gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
UniProtKB/Swiss-Prot: EID2B_HUMAN, Q96D98Function: Acts as a repressor of MYOD-dependent transcription, glucocorticoid receptor-dependent transcription, andmuscle differentiation
|
Genomic Views
for EID2B gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000019.9 NC_018930.1 NT_011109.16
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the EID2B gene promoter:
p53 RelA POU6F1 (c2) Roaz GATA-1 YY1 c-Rel STAT3 Zic3 En-1
Other transcription factors
Search SABiosciences Chromatin IP Primers for EID2B
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat EID2B |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 19q13.2 Ensembl cytogenetic band: 19q13.2 HGNC cytogenetic band: 19q13.2EID2B Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 19 GeneLoc Exon Structure GeneLoc location for GC19M040021: view genomic region
(about GC identifiers)
Start:
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40,021,630 bp from pter |
End:
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40,023,494 bp from pter |
Size:
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1,865 bases |
Orientation:
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minus strand |
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Proteins
for EID2B gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: EID2B_HUMAN, Q96D98 (See
protein sequence)Recommended Name: EP300-interacting inhibitor of differentiation 2B Size: 161 amino acids; 16985 Da
Subunit: Homodimer and heterodimer with EID2. Interacts with HDAC1 and HDAC2
Subcellular location: Nucleus
Secondary accessions: Q8N8S0Explore the universe of human proteins at neXtProt for EID2B: NX_Q96D98
EID2B Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_689574.1
ENSEMBL proteins: ENSP00000317564
Human Recombinant Protein Products:
Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005634 | nucleus |
IEA | -- |
EID2B for ontologies About GeneDecksing
EID2B Antibody Products:
Assay Products for EID2B: |
Protein
Domains /
Families
for EID2B gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
| ProtoNet protein and cluster: Q96D98 UniProtKB/Swiss-Prot: EID2B_HUMAN, Q96D98Domain: The C-terminal portion of EID2B is required for nuclear localization |
Function
for EID2B gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: EID2B_HUMAN, Q96D98Function: Acts as a repressor of MYOD-dependent transcription, glucocorticoid receptor-dependent transcription, andmuscle differentiation
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for EID2B (see all 2)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for EID2B
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: EID2B (NM_152361) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for EID2B | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat EID2B |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for EID2B |
|
Pathways & Interactions
for EID2B gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for EID2B
STRING Interaction
Network Preview (showing 5 interactants - click image to see more details)
5/6 Interacting proteins for EID2B (Q96D983 ENSP000003175644) via UniProtKB, MINT, STRING, and/or I2D (see all 6)About this table
Gene Ontology (GO): 4 biological process terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0006351 | transcription, DNA-dependent |
IEA | -- | | GO:0006355 | regulation of transcription, DNA-dependent |
IEA | -- | | GO:0007517 | muscle organ development |
IEA | -- | | GO:0030154 | cell differentiation |
IEA | -- |
EID2B for ontologies About GeneDecksing
|
Drugs & Compounds
for EID2B gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for EID2B
Search CenterWatch for drugs/clinical trials and news about EID2B
|
Transcripts
for EID2B gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for EID2B gene: NM_152361.1 Unigene Cluster for EID2B: EP300 interacting inhibitor of differentiation 2B Hs.135181 [show with all ESTs]Unigene Representative Sequence: AK0962631 Ensembl transcript including schematic representation, and UCSC links where relevant: ENST00000326282(uc002olz.1)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for EID2B (see all 2)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for EID2B
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: EID2B (NM_152361) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for EID2B | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat EID2B |
Additional cDNA sequence: AK096263.1 BC009725.1 BC040157.1 BC051333.1 1 DOTS entry: DT.70102096 23 AceView cDNA sequences: BX097841 BC040157 CA412392 BC009725 BC051333 CF127101 BP352703 BX460183 AK096263 AI093963 BE905484 BU602950 AI147883 NM_152361 BG831362 BG334233 BI834979 BI495740 BQ674089 BQ182601 AA609111 BE179442 AA527118
GeneLoc Exon Structure
|
Expression
for EID2B gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| EID2B expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: --
About this image
See EID2B Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for EID2B
SOURCE GeneReport for Unigene cluster: Hs.135181
SABiosciences Custom PCR Arrays for EID2B
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for EID2B
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat EID2B | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat EID2B | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat EID2B | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for EID2B |
Orthologs
for EID2B gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
--
ENSEMBL Gene Tree for EID2B (if available)
TreeFam Gene Tree for EID2B (if available) |
Paralogs
for EID2B gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for EID2B gene
- EID22
EID2B for paralogs About GeneDecksing
|
Genomic Variants
for EID2B gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 19 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for EID2B (40021630 - 40023494 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for EID2B
1 CNV: 5954 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing EID2B |
|
Disorders
/ Diseases
for EID2B gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
| -- |
Publications
for EID2B gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for EID2B gene integrated from 9 sources:
(articles sorted by number of sources associating them with EID2B) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- A novel EID family member, EID-3, inhibits differentiation and forms a homodimer or heterodimer with EID-2. (PubMed id 15970276)1, 2, 3 Sasajima Y.... Yuasa Y. (2005)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
- A human protein-protein interaction network: a resource for annotating the proteome. (PubMed id 16169070)1 Stelzl U.... Wanker E.E. (2005)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S....Malek J. (2004)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
|
External Searches for EID2B gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
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Genome Databases showing EID2B gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing EID2B gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing EID2B gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for EID2B | Pharmacogenomics, SNPs, Pathways |
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| | |
About This Section
| Patent Information for EID2B gene:
Search GeneIP for patents involving EID2B
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for EID2B gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for EID2B | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for EID2B | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for EID2B | | | OriGene Protein Over-expression Lysate for EID2B | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for EID2B | | OriGene 3'-UTR Clone for EID2B | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for EID2B | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for EID2B | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | OriGene Purified Protein for EID2B | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for EID2B | | OriGene Custom Protein Services for EID2B | | | OriGene Custom Immunoassay Development | | |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat EID2B | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing EID2B | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat EID2B | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat EID2B | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat EID2B | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat EID2B |
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| | | | Search Tocris compounds for EID2B |
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 | | | EID2B Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for EID2B |
|  |  |  | | | | Search ThermoFisher Antibodies for EID2B |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat EID2B |
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