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Aliases for EID2 Gene

Aliases for EID2 Gene

  • EP300 Interacting Inhibitor Of Differentiation 2 2 3
  • CREBBP/EP300 Inhibitor 2 2 3 4
  • EID-1-Like Inhibitor Of Differentiation 2 3 4
  • CREBBP/EP300 Inhibitory Protein 2 2 3
  • EID-2 3 4
  • CRI2 3 4
  • E1A Like Inhibitor Of Differentiation 2 3

External Ids for EID2 Gene

Previous HGNC Symbols for EID2 Gene

  • CRI2

Previous GeneCards Identifiers for EID2 Gene

  • GC19M044722
  • GC19M040028
  • GC19M036475

Summaries for EID2 Gene

GeneCards Summary for EID2 Gene

EID2 (EP300 Interacting Inhibitor Of Differentiation 2) is a Protein Coding gene. Among its related pathways are TGF-beta Receptor Signaling Pathway. GO annotations related to this gene include SMAD binding. An important paralog of this gene is EID2B.

UniProtKB/Swiss-Prot for EID2 Gene

  • Interacts with EP300 and acts as a repressor of MYOD-dependent transcription and muscle differentiation. Inhibits EP300 histone acetyltransferase activity. Acts as a repressor of TGFB/SMAD transcriptional responses. May act as a repressor of the TGFB/SMAD3-dependent signaling by selectively blocking formation of TGFB-induced SMAD3-SMAD4 complex.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for EID2 Gene

Genomics for EID2 Gene

Regulatory Elements for EID2 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for EID2 Gene

Chromosome:
19
Start:
39,538,250 bp from pter
End:
39,540,230 bp from pter
Size:
1,981 bases
Orientation:
Minus strand

Genomic View for EID2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
GeneLoc Logo Gene Density

RefSeq DNA sequence for EID2 Gene

Proteins for EID2 Gene

  • Protein details for EID2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8N6I1-EID2_HUMAN
    Recommended name:
    EP300-interacting inhibitor of differentiation 2
    Protein Accession:
    Q8N6I1
    Secondary Accessions:
    • A7YQ71
    • Q6X7T0
    • Q6ZR61

    Protein attributes for EID2 Gene

    Size:
    236 amino acids
    Molecular mass:
    25190 Da
    Quaternary structure:
    • Heterodimer with EID2B. Interacts with the C-terminus of EP300. Interacts with HDAC1 and HDAC2. Interacts with SMAD2, SMAD4 and with the MH2 domain of SMAD3.

    Alternative splice isoforms for EID2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for EID2 Gene

Proteomics data for EID2 Gene at MOPED

Post-translational modifications for EID2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for EID2 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for EID2 Gene

Domains & Families for EID2 Gene

Protein Domains for EID2 Gene

ProtoNet:

Suggested Antigen Peptide Sequences for EID2 Gene

Graphical View of Domain Structure for InterPro Entry

Q8N6I1

UniProtKB/Swiss-Prot:

EID2_HUMAN :
  • The N-terminal portion of EID2 is required for nuclear localization.
Domain:
  • The N-terminal portion of EID2 is required for nuclear localization.
genes like me logo Genes that share domains with EID2: view

No data available for Gene Families for EID2 Gene

Function for EID2 Gene

Molecular function for EID2 Gene

UniProtKB/Swiss-Prot Function:
Interacts with EP300 and acts as a repressor of MYOD-dependent transcription and muscle differentiation. Inhibits EP300 histone acetyltransferase activity. Acts as a repressor of TGFB/SMAD transcriptional responses. May act as a repressor of the TGFB/SMAD3-dependent signaling by selectively blocking formation of TGFB-induced SMAD3-SMAD4 complex.

Gene Ontology (GO) - Molecular Function for EID2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 14612439
GO:0046332 SMAD binding IDA 14612439
genes like me logo Genes that share ontologies with EID2: view

Phenotypes for EID2 Gene

GenomeRNAi human phenotypes for EID2:
genes like me logo Genes that share phenotypes with EID2: view

Animal Model Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for EID2

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targets and HOMER Transcription for EID2 Gene

Localization for EID2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for EID2 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for EID2 Gene COMPARTMENTS Subcellular localization image for EID2 gene
Compartment Confidence
nucleus 4

Gene Ontology (GO) - Cellular Components for EID2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IC 14612439
GO:0005654 nucleoplasm IDA --
genes like me logo Genes that share ontologies with EID2: view

Pathways & Interactions for EID2 Gene

genes like me logo Genes that share pathways with EID2: view

Pathways by source for EID2 Gene

1 BioSystems pathway for EID2 Gene

SIGNOR curated interactions for EID2 Gene

Inactivates:

Gene Ontology (GO) - Biological Process for EID2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0007181 transforming growth factor beta receptor complex assembly IDA 14612439
GO:0007183 SMAD protein complex assembly IDA 14612439
GO:0007517 muscle organ development IEA --
GO:0017015 regulation of transforming growth factor beta receptor signaling pathway IDA 14612439
genes like me logo Genes that share ontologies with EID2: view

Drugs & Compounds for EID2 Gene

No Compound Related Data Available

Transcripts for EID2 Gene

mRNA/cDNA for EID2 Gene

(1) REFSEQ mRNAs :
(4) Additional mRNA sequences :
(71) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for EID2 Gene

EP300 interacting inhibitor of differentiation 2:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for EID2

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for EID2 Gene

No ASD Table

Relevant External Links for EID2 Gene

GeneLoc Exon Structure for
EID2
ECgene alternative splicing isoforms for
EID2

Expression for EID2 Gene

mRNA expression in normal human tissues for EID2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for EID2 Gene

This gene is overexpressed in Bone (61.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for EID2 Gene



SOURCE GeneReport for Unigene cluster for EID2 Gene Hs.18949

mRNA Expression by UniProt/SwissProt for EID2 Gene

Q8N6I1-EID2_HUMAN
Tissue specificity: Most abundantly expressed in placenta. Highly expressed in liver, brain, heart, skeletal muscle, and kidney.
genes like me logo Genes that share expression patterns with EID2: view

Protein tissue co-expression partners for EID2 Gene

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues for EID2 Gene

Orthologs for EID2 Gene

This gene was present in the common ancestor of mammals.

Orthologs for EID2 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia EID2 35
  • 83.18 (n)
  • 78.44 (a)
EID2 36
  • 77 (a)
OneToOne
dog
(Canis familiaris)
Mammalia EID2 35
  • 74.64 (n)
  • 75.54 (a)
EID2 36
  • 83 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Eid2 35
  • 72.79 (n)
  • 73.08 (a)
Eid2 16
Eid2 36
  • 76 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia EID2 35
  • 99.86 (n)
  • 99.58 (a)
EID2 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Eid2 35
  • 74.5 (n)
  • 76.07 (a)
Species with no ortholog for EID2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for EID2 Gene

ENSEMBL:
Gene Tree for EID2 (if available)
TreeFam:
Gene Tree for EID2 (if available)

Paralogs for EID2 Gene

Paralogs for EID2 Gene

Pseudogenes.org Pseudogenes for EID2 Gene

genes like me logo Genes that share paralogs with EID2: view

Variants for EID2 Gene

Sequence variations from dbSNP and Humsavar for EID2 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type MAF
rs1045389 -- 39,539,365(-) AGTTA(G/T)GTGGT utr-variant-3-prime
rs1433108 -- 39,539,561(+) TCAAG(C/T)TCTTG synonymous-codon, reference
rs3746086 - 39,539,901(+) GACCT(G/T)CCCTG reference, missense
rs7252027 - 39,540,064(+) GTCTG(C/T)GGGCA missense, reference
rs8100692 -- 39,541,492(+) tggga(C/T)tacag upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for EID2 Gene

Variant ID Type Subtype PubMed ID
dgv3863n71 CNV Loss 21882294
dgv3864n71 CNV Loss 21882294
nsv911694 CNV Loss 21882294

Variation tolerance for EID2 Gene

Residual Variation Intolerance Score: 63.98% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 8.22; 84.92% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for EID2 Gene

HapMap Linkage Disequilibrium report
EID2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for EID2 Gene

Disorders for EID2 Gene

Relevant External Links for EID2

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
EID2
genes like me logo Genes that share disorders with EID2: view

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for EID2 Gene

Publications for EID2 Gene

  1. EID-2, a novel member of the EID family of p300-binding proteins inhibits transactivation by MyoD. (PMID: 14585496) Ji A. … MacLellan W.R. (Gene 2003) 2 67
  2. Interactions between the Nse3 and Nse4 components of the SMC5-6 complex identify evolutionarily conserved interactions between MAGE and EID Families. (PMID: 21364888) Hudson J.J. … Palecek J. (PLoS ONE 2011) 67
  3. Toward a confocal subcellular atlas of the human proteome. (PMID: 18029348) Barbe L. … Andersson-Svahn H. (Mol. Cell Proteomics 2008) 67
  4. A novel EID family member, EID-3, inhibits differentiation and forms a homodimer or heterodimer with EID-2. (PMID: 15970276) Sasajima Y. … Yuasa Y. (Biochem. Biophys. Res. Commun. 2005) 67
  5. A novel E1A-like inhibitor of differentiation (EID) family member, EID-2, suppresses transforming growth factor (TGF)-beta signaling by blocking TGF-beta-induced formation of Smad3-Smad4 complexes. (PMID: 14612439) Lee H.-J. … Kim S.-J. (J. Biol. Chem. 2004) 67

Products for EID2 Gene

Sources for EID2 Gene

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