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Aliases for EID1 Gene

Aliases for EID1 Gene

  • EP300 Interacting Inhibitor Of Differentiation 1 2 3 5
  • CREBBP/EP300 Inhibitory Protein 1 2 3 4
  • E1A-Like Inhibitor Of Differentiation 1 3 4
  • 21 KDa PRb-Associated Protein 3 4
  • CREBBP/EP300 Inhibitor 1 2 3
  • C15orf3 3 4
  • EID-1 3 4
  • RBP21 3 4
  • CRI1 3 4
  • Retinoblastoma Protein-Associated Protein 3
  • Rb- And P300-Binding Protein EID-1 3
  • NB4 Apoptosis Related Protein 3
  • IRO45620 3
  • PNAS-22 3
  • PTD014 3

External Ids for EID1 Gene

Previous HGNC Symbols for EID1 Gene

  • C15orf3
  • CRI1

Previous GeneCards Identifiers for EID1 Gene

  • GC15P046958
  • GC15P049171
  • GC15P049172

Summaries for EID1 Gene

GeneCards Summary for EID1 Gene

EID1 (EP300 Interacting Inhibitor Of Differentiation 1) is a Protein Coding gene. GO annotations related to this gene include transcription corepressor activity and histone acetyltransferase regulator activity.

UniProtKB/Swiss-Prot for EID1 Gene

  • Interacts with RB1 and EP300 and acts as a repressor of MYOD1 transactivation. Inhibits EP300 and CBP histone acetyltransferase activity. May be involved in coupling cell cycle exit to the transcriptional activation of genes required for cellular differentiation. May act as a candidate coinhibitory factor for NR0B2 that can be directly linked to transcription inhibitory mechanisms.

Gene Wiki entry for EID1 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for EID1 Gene

Genomics for EID1 Gene

Regulatory Elements for EID1 Gene

Enhancers for EID1 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around EID1 on UCSC Golden Path with GeneCards custom track

Promoters for EID1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around EID1 on UCSC Golden Path with GeneCards custom track

Genomic Location for EID1 Gene

Chromosome:
15
Start:
48,877,886 bp from pter
End:
48,880,183 bp from pter
Size:
2,298 bases
Orientation:
Plus strand

Genomic View for EID1 Gene

Genes around EID1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
EID1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for EID1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for EID1 Gene

Proteins for EID1 Gene

  • Protein details for EID1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9Y6B2-EID1_HUMAN
    Recommended name:
    EP300-interacting inhibitor of differentiation 1
    Protein Accession:
    Q9Y6B2
    Secondary Accessions:
    • B2RD11
    • Q8N7I4
    • Q9BZT9

    Protein attributes for EID1 Gene

    Size:
    187 amino acids
    Molecular mass:
    20876 Da
    Quaternary structure:
    • Interacts via its LXCXE motif with the entire pocket region of RB1. Interacts with EP300, NR0B2 and TRIM27.
    Miscellaneous:
    • Inhibition of MYOD1 may be partly due to the ability of EID1 to bind and inhibit EP300 histone acetyltransferase activity.
    SequenceCaution:
    • Sequence=AAK07524.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for EID1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for EID1 Gene

Proteomics data for EID1 Gene at MOPED

Post-translational modifications for EID1 Gene

  • Ubiquitinated in U2OS osteosarcoma cells and is rapidly degraded by proteasome as cells exit the cell cycle exit.
  • Ubiquitination at Lys 72 and Lys 133
  • Modification sites at PhosphoSitePlus

Other Protein References for EID1 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for EID1 Gene

Domains & Families for EID1 Gene

Protein Domains for EID1 Gene

ProtoNet:

Suggested Antigen Peptide Sequences for EID1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with EID1: view

No data available for Gene Families and UniProtKB/Swiss-Prot for EID1 Gene

Function for EID1 Gene

Molecular function for EID1 Gene

UniProtKB/Swiss-Prot Function:
Interacts with RB1 and EP300 and acts as a repressor of MYOD1 transactivation. Inhibits EP300 and CBP histone acetyltransferase activity. May be involved in coupling cell cycle exit to the transcriptional activation of genes required for cellular differentiation. May act as a candidate coinhibitory factor for NR0B2 that can be directly linked to transcription inhibitory mechanisms.
UniProtKB/Swiss-Prot Induction:
Down-regulated in differentiating U-937 leukemia cells.

Gene Ontology (GO) - Molecular Function for EID1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0035035 histone acetyltransferase binding IDA 11073990
genes like me logo Genes that share ontologies with EID1: view

Phenotypes for EID1 Gene

GenomeRNAi human phenotypes for EID1:
genes like me logo Genes that share phenotypes with EID1: view

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for EID1 Gene

Localization for EID1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for EID1 Gene

Nucleus. Cytoplasm. Note=May shuttle between nucleus and cytoplasm. {ECO:0000250 UniProtKB:Q9DCR4, ECO:0000269 PubMed:11223246}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for EID1 Gene COMPARTMENTS Subcellular localization image for EID1 gene
Compartment Confidence
nucleus 5

Gene Ontology (GO) - Cellular Components for EID1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IPI 11073990
GO:0005737 cytoplasm IEA --
genes like me logo Genes that share ontologies with EID1: view

Pathways & Interactions for EID1 Gene

SuperPathways for EID1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for EID1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000122 negative regulation of transcription from RNA polymerase II promoter IDA 11073990
GO:0035065 regulation of histone acetylation IDA 11073990
GO:0045892 negative regulation of transcription, DNA-templated IDA 11073990
genes like me logo Genes that share ontologies with EID1: view

No data available for Pathways by source and SIGNOR curated interactions for EID1 Gene

Drugs & Compounds for EID1 Gene

No Compound Related Data Available

Transcripts for EID1 Gene

mRNA/cDNA for EID1 Gene

Unigene Clusters for EID1 Gene

EP300 interacting inhibitor of differentiation 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for EID1 Gene

No ASD Table

Relevant External Links for EID1 Gene

GeneLoc Exon Structure for
EID1
ECgene alternative splicing isoforms for
EID1

Expression for EID1 Gene

mRNA expression in normal human tissues for EID1 Gene

SOURCE GeneReport for Unigene cluster for EID1 Gene Hs.255973

mRNA Expression by UniProt/SwissProt for EID1 Gene

Q9Y6B2-EID1_HUMAN
Tissue specificity: Widely expressed. Most abundantly expressed in heart, skeletal muscle, pancreas, brain and testis. Expressed at much lower levels in placenta and peripheral blood leukocyte. Barely detectable in lung. Also weakly expressed in lung carcinoma A-549 and various leukemia cell lines.
genes like me logo Genes that share expression patterns with EID1: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression and Protein tissue co-expression partners for EID1 Gene

Orthologs for EID1 Gene

This gene was present in the common ancestor of mammals.

Orthologs for EID1 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia EID1 35
  • 88.95 (n)
  • 87.17 (a)
-- 36
  • 85 (a)
OneToMany
EID1 36
  • 85 (a)
OneToMany
dog
(Canis familiaris)
Mammalia EID1 35
  • 89.48 (n)
  • 89.3 (a)
EID1 36
  • 87 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Eid1 35
  • 73.59 (n)
  • 73.38 (a)
Eid1 16
Eid1 36
  • 70 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia EID1 35
  • 99.47 (n)
  • 99.47 (a)
EID1 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Eid1 35
  • 73.81 (n)
  • 74.68 (a)
Species with no ortholog for EID1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for EID1 Gene

ENSEMBL:
Gene Tree for EID1 (if available)
TreeFam:
Gene Tree for EID1 (if available)

Paralogs for EID1 Gene

No data available for Paralogs for EID1 Gene

Variants for EID1 Gene

Structural Variations from Database of Genomic Variants (DGV) for EID1 Gene

Variant ID Type Subtype PubMed ID
nsv833001 CNV Gain 17160897

Variation tolerance for EID1 Gene

Residual Variation Intolerance Score: 25.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.37; 8.19% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations from dbSNP and Humsavar and Relevant External Links for EID1 Gene

Disorders for EID1 Gene

Relevant External Links for EID1

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
EID1

No disorders were found for EID1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for EID1 Gene

Publications for EID1 Gene

  1. A novel Rb- and p300-binding protein inhibits transactivation by MyoD. (PMID: 11073990) MacLellan W.R. … Schneider M.D. (Mol. Cell. Biol. 2000) 2 3 4 67
  2. Identification and expression analysis of C15orf3, a novel gene on chromosome 15q21.1-->q21.2. (PMID: 10828624) Carim L. … Escarceller M. (Cytogenet. Cell Genet. 2000) 2 3
  3. Cells degrade a novel inhibitor of differentiation with E1A-like properties upon exiting the cell cycle. (PMID: 11073989) Miyake S. … Kaelin W.G. Jr. (Mol. Cell. Biol. 2000) 3 23
  4. FBXO21 mediates the ubiquitylation and proteasomal degradation of EID1. (PMID: 26085330) Watanabe K. … Nakayama K.I. (Genes Cells 2015) 3
  5. A deep proteomics perspective on CRM1-mediated nuclear export and nucleocytoplasmic partitioning. (PMID: 26673895) KA+rlA+ K. … GAPrlich D. (Elife 2015) 3

Products for EID1 Gene

Sources for EID1 Gene

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