EHMT2 Gene
protein-coding GIFtS: 60
GCID: GC06M031847
|
|
euchromatic histone-lysine N-methyltransferase 2(Previous names: chromosome 6 open reading frame 30, HLA-B associated transcript...)
(Previous symbols: C6orf30, BAT8)
| |
Aliases
for EHMT2 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Euchromatic Histone-Lysine N-Methyltransferase 21 2 3 | | HLA-B-Associated Transcript 82 3 | | BAT81 2 3 | | Em:AF134726.31 | | C6orf301 2 3 | | NG36/G9a1 | | G9A1 2 3 | | Chromosome 6 Open Reading Frame 301 | | KMT1C1 2 3 | | GAT82 | | HLA-B Associated Transcript 81 2 | | Ankyrin Repeat-Containing Protein2 | | Histone H3-K9 Methyltransferase 32 3 | | G9A Histone Methyltransferase2 | | Lysine N-Methyltransferase 1C2 3 | | Histone-Lysine N-Methyltransferase EHMT22 | | Protein G9a2 3 | | Histone-Lysine N-Methyltransferase, H3 Lysine-9 Specific 32 | | NG362 3 | | EC 2.1.1.-3 | | H3-K9-HMTase 32 3 | | EC 2.1.1.433 |
Export aliases for EHMT2 gene to outside databasesPrevious GC identifers: GC06M031956 GC06M031633 |
Summaries
for EHMT2 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for EHMT2:
A cluster of genes, BAT1-BAT5, has been localized in the vicinity of the genes for TNF alpha and TNF beta. This gene isfound near this cluster; it was mapped near the gene for C2 within a 120-kb region that included a HSP70 gene pair.These genes are all within the human major histocompatibility complex class III region. This gene was thought to betwo different genes, NG36 and G9a, adjacent to each other but a recent publication shows that there is only a singlegene. The protein encoded by this gene is thought to be involved in intracellular protein-protein interaction. Thereare three alternatively spliced transcript variants of this gene but only two are fully described. (provided byRefSeq, Jul 2008)
UniProtKB/Swiss-Prot: EHMT2_HUMAN, Q96KQ7Function: Histone methyltransferase that specifically mono- and dimethylates 'Lys-9' of histone H3 (H3K9me1 andH3K9me2, respectively) in euchromatin. H3K9me represents a specific tag for epigenetic transcriptional repression byrecruiting HP1 proteins to methylated histones. Also mediates monomethylation of 'Lys-56' of histone H3 (H3K56me1) inG1 phase, leading to promote interaction between histone H3 and PCNA and regulating DNA replication. Also weaklymethylates 'Lys-27' of histone H3 (H3K27me). Also required for DNA methylation, the histone methyltransferase activityis not required for DNA methylation, suggesting that these 2 activities function independently. Probably targeted tohistone H3 by different DNA-binding proteins like E2F6, MGA, MAX and/or DP1. May also methylate histone H1. Inaddition to the histone methyltransferase activity, also methylates non-histone proteins: mediates dimethylation of'Lys-373' of p53/TP53. Also methylates CDYL, WIZ, ACIN1, DNMT1, HDAC1, ERCC6, KLF12 and itself
Gene Wiki entry for EHMT2
|
Genomic Views
for EHMT2 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000006.11 NC_018917.1 NT_007592.15 NT_113891.2 NT_167244.1 NT_167245.1 NT_167247.1 NT_167248.1
- NT_167249.1
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the EHMT2 gene promoter:
AREB6 C/EBPbeta AP-1 ATF-2 p300 c-Jun IRF-1
Other transcription factors
Search SABiosciences Chromatin IP Primers for EHMT2
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat EHMT2 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 6p21.31 Ensembl cytogenetic band: 6p21.33 HGNC cytogenetic band: 6p21.3EHMT2 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 6 GeneLoc Exon Structure GeneLoc location for GC06M031847: view genomic region
(about GC identifiers)
Start:
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31,847,536 bp from pter |
End:
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31,865,464 bp from pter |
Size:
|
17,929 bases |
Orientation:
|
minus strand |
6 alternative locations:
| Chr6-,ALT_REF_LOCI_1 31,858,893-31,885,128 | Chr6-,ALT_REF_LOCI_6 31,837,931-31,891,439 | Chr6-,ALT_REF_LOCI_3 31,829,721-31,858,687 | | Chr6-,ALT_REF_LOCI_5 31,838,832-31,856,767 | Chr6-,ALT_REF_LOCI_2 31,835,086-31,892,202 | Chr6-,ALT_REF_LOCI_7 31,769,744-31,779,595 | |
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Proteins
for EHMT2 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: EHMT2_HUMAN, Q96KQ7 (See
protein sequence)Recommended Name: Histone-lysine N-methyltransferase EHMT2 Size: 1210 amino acids; 132370 Da
Subunit: Heterodimer; heterodimerizes with EHMT1/GLP. Interacts with GFI1B and WIZ. Part of the E2F6.com-1 complex inG0 phase composed of E2F6, MGA, MAX, TFDP1, CBX3, BAT8, EHMT1, RING1, RNF2, MBLR, L3MBTL2 and YAF2. Part of a complexcomposed of TRIM28, HDAC1, HDAC2 and EHMT2. Interacts with UHRF1
Subcellular location: Nucleus. Chromosome. Note=Associates with euchromatic regions. Does not associate withheterochromatin
Caution: While NG36 and G9a were originally thought to derive from 2 separate genes, all G9A transcripts also containthe in frame coding sequence of NG36 (PubMed:11707778)
Caution: It is uncertain whether Met-1 or Met-21 is the initiator methionine
Sequence caution: Sequence=AAD21811.1; Type=Erroneous gene model prediction; Sequence=AAD21812.1; Type=Erroneous genemodel prediction; Sequence=AAH02686.2; Type=Erroneous initiation; Note=Translation N-terminally shortened;Sequence=AAH09351.1; Type=Erroneous initiation; Note=Translation N-terminally shortened; Sequence=AAH18718.1;Type=Erroneous initiation; Note=Translation N-terminally extended; Sequence=AAH20970.2; Type=Erroneous initiation;Note=Translation N-terminally shortened; Sequence=BAB63294.1; Type=Erroneous gene model prediction;Sequence=BAB63295.1; Type=Erroneous gene model prediction; Sequence=CAA49491.1; Type=Erroneous initiation;Note=Translation N-terminally extended;
4 PDB 3D structures from  and Proteopedia  for EHMT2:2O8J (3D)
3DM1 (3D)
3K5K (3D)
3RJW (3D)
Secondary accessions: B0UZY2 Q14349 Q5JP83 Q5JQ92 Q5JQA1 Q5JQG3 Q6PK06 Q96MH5 Q96QD0 Q9UQL8 Q9Y331Alternative splicing: 3 isoforms: Q96KQ7-1 Q96KQ7-2 Q96KQ7-3 Explore the universe of human proteins at neXtProt for EHMT2: NX_Q96KQ7
Post-translational modifications:
Methylated at Lys-185; automethylated1
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q96KQ7
EHMT2 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins (2 alternative transcripts):
NP_006700.3 NP_079532.5
ENSEMBL proteins: ENSP00000379078 ENSP00000364678 ENSP00000364680 ENSP00000364687 ENSP00000412353
Human Recombinant Protein Products:
Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view): About this table
EHMT2 for ontologies About GeneDecksing
EHMT2 Antibody Products:
Assay Products for EHMT2: |
Protein
Domains /
Families
for EHMT2 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
EHMT2 for domains About GeneDecksing
5/6 InterPro domains/families (see all 6):Graphical View of Domain Structure for InterPro Entry Q96KQ7ProtoNet protein and cluster: Q96KQ7 4 Blocks protein families: IPB001214 Nuclear protein SET IPB002110 Ankyrin repeat signature IPB003606 Nuclear protein Zn2+-binding IPB003616 SET-related region
UniProtKB/Swiss-Prot: EHMT2_HUMAN, Q96KQ7Domain: The SET domain mediates interaction with WIZDomain: The ANK repeats bind H3K9me1 and H3K9me2Similarity: Belongs to the histone-lysine methyltransferase family. Suvar3-9 subfamilySimilarity: Contains 7 ANK repeatsSimilarity: Contains 1 post-SET domainSimilarity: Contains 1 pre-SET domainSimilarity: Contains 1 SET domain |
Function
for EHMT2 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: EHMT2_HUMAN, Q96KQ7Function: Histone methyltransferase that specifically mono- and dimethylates 'Lys-9' of histone H3 (H3K9me1 andH3K9me2, respectively) in euchromatin. H3K9me represents a specific tag for epigenetic transcriptional repression byrecruiting HP1 proteins to methylated histones. Also mediates monomethylation of 'Lys-56' of histone H3 (H3K56me1) inG1 phase, leading to promote interaction between histone H3 and PCNA and regulating DNA replication. Also weaklymethylates 'Lys-27' of histone H3 (H3K27me). Also required for DNA methylation, the histone methyltransferase activityis not required for DNA methylation, suggesting that these 2 activities function independently. Probably targeted tohistone H3 by different DNA-binding proteins like E2F6, MGA, MAX and/or DP1. May also methylate histone H1. Inaddition to the histone methyltransferase activity, also methylates non-histone proteins: mediates dimethylation of'Lys-373' of p53/TP53. Also methylates CDYL, WIZ, ACIN1, DNMT1, HDAC1, ERCC6, KLF12 and itselfCatalytic activity: S-adenosyl-L-methionine + L-lysine-[histone] = S-adenosyl-L-homocysteine +N(6)-methyl-L-lysine-[histone]Enzyme Numbers (IUBMB): EC 2.1.1.431 EC 2.1.1.-1
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for EHMT2 (see all 5)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for EHMT2 (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
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Synthesis Service for EHMT2 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat EHMT2 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for EHMT2 |
Gene Ontology (GO): 5/7 molecular function terms (GO ID links to tree view) (see all 7): About this table
EHMT2 for ontologies About GeneDecksing
Animal Models:
Mouse knock-outs for EHMT2: Ehmt2tm1Yshk Ehmt2tm2.1Yshk
11 MGI mutant phenotypes (inferred from 6 alleles ) (MGI details for Ehmt2):
EHMT2 for phenotypes About GeneDecksing
|
Pathways & Interactions
for EHMT2 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | Chromatin Regulation / Acetylation | | | 2 | Regulation of Androgen receptor activity | | | 3 | Lysine degradation | | | 4 | Signal transduction Activin A signaling regulation | |
Pathway sources
See GeneCards unified pathways
Show all pathways
1 EMD Millipore Pathway for EHMT2
1 
Cell Signaling Technology (CST) Pathway for EHMT2
1  BioSystems Pathway for EHMT2
1 
Kegg Pathway (Kegg details for EHMT2):
EHMT2 for pathways About GeneDecksing
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for EHMT2
STRING Interaction
Network Preview (showing 5 interactants - click image to see 25)
5/95 Interacting proteins for EHMT2 (Q96KQ71, 2, 3 ENSP000003646874) via UniProtKB, MINT, STRING, and/or I2D (see all 95)About this table
Gene Ontology (GO): 5/16 biological process terms (GO ID links to tree view) (see all 16): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0000122 | negative regulation of transcription from RNA polymerase II promoter |
IEA | -- | | GO:0000239 | pachytene |
IEA | -- | | GO:0006275 | regulation of DNA replication |
IMP | -- | | GO:0006306 | DNA methylation |
ISS | -- | | GO:0006357 | regulation of transcription from RNA polymerase II promoter |
-- | -- |
EHMT2 for ontologies About GeneDecksing
|
Drugs & Compounds
for EHMT2 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
EHMT2 for compounds About GeneDecksing
 Compounds for EHMT2 available from Tocris Bioscience About this table
| Compound | Action |
CAS
# |
|---|
| UNC 0638 | Selective G9a and GLP histone lysine methyltransferase inhibitor | [1255517-77-1] | | UNC 0224 | Potent G9a histone lysine methyltransferase (HMTase) inhibitor | [1197196-48-7] | | BIX 01294 | G9a-like protein and G9a histone lysine methyltransferase (HMTase) inhibitor | [935693-62-2] |
3 HMDB Compounds for EHMT2 About this table
1 Novoseek chemical compound relationship for EHMT2 gene About this table
Search CenterWatch for drugs/clinical trials and news about EHMT2
|
Transcripts
for EHMT2 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for EHMT2 gene (2 alternative transcripts): NM_006709.3 NM_025256.5 Unigene Cluster for EHMT2: Euchromatic histone-lysine N-methyltransferase 2 Hs.709218 [show with all ESTs]Unigene Representative Sequence: AB20943312 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000478491 ENST00000461880 ENST00000494816(uc003nxx.1) ENST00000480912(uc003nxy.1)
ENST00000395728 ENST00000375528(uc011don.1) ENST00000375530 ENST00000375537(uc003nxz.1 uc003nya.1)
ENST00000436026 ENST00000477678 ENST00000463484 ENST00000465429(uc003nyb.1)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for EHMT2 (see all 5)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for EHMT2 (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector (see all 2): EHMT2 (NM_006709) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for EHMT2 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat EHMT2 |
Additional cDNA sequence: AB209433.2 AJ315532.1 AK302904.1 BC002686.1 BC009351.1 BC018718.1 BC020970.1 X69838.1 17 DOTS entries: DT.445503 DT.102841782 DT.95331384 DT.91779944 DT.100788894 DT.121318949 DT.100788886 DT.91779993 DT.95331377 DT.95331392 DT.100788888 DT.100788892 DT.70102212 DT.100788896 DT.40115699 DT.95131925 DT.95331421 24/332 AceView cDNA sequences (see all 332): BC020970 BU507178 AW131154 AW627708 CK822427 AI198369 CR624754 BF221510 BF725830 AI380588 BU158595 BE328125 AI262836 CD245439 BQ070714 AW245851 AA219452 BF796440 BM669954 NM_025256 BU507640 BC002686 CB244002 BU173832
GeneLoc Exon Structure
|
Expression
for EHMT2 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| EHMT2 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: CCTGGGGGTG
About this image
See EHMT2 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for EHMT2
SOURCE GeneReport for Unigene cluster: Hs.709218
UniProtKB/Swiss-Prot: EHMT2_HUMAN, Q96KQ7Tissue specificity: Expressed in all tissues examined, with high levels in fetal liver, thymus, lymph node, spleen andperipheral blood leukocytes and lower level in bone marrow
SABiosciences Expression via Pathway-Focused PCR Array including EHMT2:
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for EHMT2
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat EHMT2 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat EHMT2 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat EHMT2 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for EHMT2 |
Orthologs
for EHMT2 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of eukaryotes.
Orthologs for EHMT2 gene from 6/20 species (see all 20) About this table
ENSEMBL Gene Tree for EHMT2 (if available)
TreeFam Gene Tree for EHMT2 (if available) |
Paralogs
for EHMT2 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for EHMT2 gene
- NSD12 EZH12 WHSC12 SUV39H22 WHSC1L12 SETDB22 SETD22 SUV39H12
- EHMT12 SETDB12 EZH22
8 SIMAP similar genes for EHMT2 using alignment to 11 protein entries: EHMT2_HUMAN (see all proteins):FP13812 EHMT1 SUV39H2 IkBa PSMD10 DKFZp761E1322
MTPN ANKDD1A
EHMT2 for paralogs About GeneDecksing
|
Genomic Variants
for EHMT2 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 6 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for EHMT2 (31847536 - 31865464 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for EHMT2: --
Human Gene Mutation Database (HGMD): EHMT2
| SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing EHMT2 |
|
Disorders
/ Diseases
for EHMT2 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database, Novoseek,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
EHMT2 for disorders About GeneDecksing
OMIM gene information: 604599
OMIM disorders: --
20/21  diseases for EHMT2 (see all 21): About MalaCardsprader-willi syndrome idiopathic pulmonary fibrosis systemic lupus erythematosus lupus erythematosus
pulmonary fibrosis sporadic breast cancer macular degeneration cockayne syndrome
fibrosis vaccinia breast cancer homocysteine
hepatocellular carcinoma gastric cancer colorectal cancer ataxia
esophagitis adenocarcinoma carcinoma hepatitis
2 Novoseek disease relationships for EHMT2 gene About this table
Human Genome Epidemiology (HuGE) Navigator: EHMT2 (8 documents)
Export disorders for EHMT2 gene to outside databases
|
Publications
for EHMT2 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for EHMT2 gene, integrated from 9 sources (see all 144):
(articles sorted by number of sources associating them with EHMT2) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- The G9a gene in the human major histocompatibility complex encodes a novel protein containing ankyrin-like repeats. (PubMed id 8457211)1, 2, 3, 9 Milner C.M. and Campbell R.D. (1993)
- Set domain-containing protein, G9a, is a novel lysine-preferring mammalian histone methyltransferase with hyperactivity and specific selectivity to lysines 9 and 27 of histone H3. (PubMed id 11316813)1, 2, 3, 9 Tachibana M.... Shinkai Y. (2001)
- Novel NG36/G9a gene products encoded within the human and mouse MHC class III regions. (PubMed id 11707778)1, 2, 9 Brown S.E.... Sanderson C.M. (2001)
- G9a and Glp methylate lysine 373 in the tumor suppres sor p53. (PubMed id 20118233)1, 2, 9 Huang J....Berger S.L. (2010)
- UHRF1 binds G9a and participates in p21 transcriptional regulation in mammalian cells. (PubMed id 19056828)1, 2, 9 Kim J.K....Pradhan S. (2009)
- Histone H3 lysine 56 methylation regulates DNA replication through its interaction wwith PCNA. (PubMed id 22387026)1, 2 Yu Y.... Grunstein M. (2012)
- Maintenance of silent chromatin through replication r equires SWI/SNF-like chromatin remodeler SMARCAD1. (PubMed id 21549307)1, 2 Rowbotham S.P....Mermoud J.E. (2011)
- Structural biology of human H3K9 methyltransferases. (PubMed id 20084102)1, 2 Wu H....Schapira M. (2010)
- Zinc finger protein Wiz links G9a/GLP histone methyltransferases to the co-repressor molecule CtBP. (PubMed id 16702210)1, 2 Ueda J.... Shinkai Y. (2006)
- Gfi1b alters histone methylation at target gene promoters and sites of gamma-satellite containing heterochromatin. (PubMed id 16688220)1, 2 Vassen L.... Moeroey T. (2006)
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External Searches for EHMT2 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
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Genome Databases showing EHMT2 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
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Other Databases showing EHMT2 gene
(According to HUGE)
About This Section
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Specialized Databases showing EHMT2 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
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| Name | Description |
| PharmGKB entry for EHMT2 | Pharmacogenomics, SNPs, Pathways |
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About This Section
| Patent Information for EHMT2 gene:
Search GeneIP for patents involving EHMT2
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
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Products
for EHMT2 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
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| | |  | OriGene Antibodies for EHMT2 | | OriGene shRNA RFP for EHMT2 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for EHMT2 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for EHMT2 | | | OriGene Protein Over-expression Lysate for EHMT2 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for EHMT2 | | OriGene 3'-UTR Clone for EHMT2 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for EHMT2 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for EHMT2 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | OriGene Purified Protein for EHMT2 | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for EHMT2 | | OriGene Custom Protein Services for EHMT2 | | | OriGene Custom Immunoassay Development | | |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat EHMT2 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing EHMT2 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat EHMT2 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat EHMT2 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat EHMT2 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat EHMT2 |
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| | Antibodies & Assays for EHMT2 |
| | | | Tocris compounds for EHMT2 |
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 | | | EHMT2 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for EHMT2 |
|  |  |  | | | | ThermoFisher Antibodies for EHMT2 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat EHMT2 |
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