EHMT1 Gene
protein-coding GIFtS: 62
GCID: GC09P140513
|
|
euchromatic histone-lysine N-methyltransferase 1(Previous name: euchromatic histone methyltransferase 1 )
| |
Aliases
for EHMT1 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Euchromatic Histone-Lysine N-Methyltransferase 11 2 3 | | H3-K9-HMTase 52 3 | | Eu-HMTase11 2 3 | | FLJ128791 | | KMT1D1 2 3 | | Euchromatic Histone Methyltransferase 11 | | EUHMTASE12 3 5 | | FP138122 | | BA188C12.11 | | G9a Like Protein2 | | KIAA18761 3 | | Histone-Lysine N-Methyltransferase EHMT12 | | Histone H3-K9 Methyltransferase 52 3 | | Histone-Lysine N-Methyltransferase, H3 Lysine-9 Specific 52 | | Lysine N-Methyltransferase 1D2 3 | | EC 2.1.1.-3 | | GLP2 3 | | EC 2.1.1.433 | | GLP12 3 | | DEL9q345 | | G9a-Like Protein 12 3 | | |
Export aliases for EHMT1 gene to outside databasesPrevious GC identifers: GC09P135825 GC09P137881 GC09P139633 GC09P139725 GC09P110067 |
Summaries
for EHMT1 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for EHMT1:
The protein encoded by this gene is a histone methyltransferase that is part of the E2F6 complex, which repressestranscription. The encoded protein methylates the Lys-9 position of histone H3, which tags it for transcriptionalrepression. This protein may be involved in the silencing of MYC- and E2F-responsive genes and therefore could play arole in the G0/G1 cell cycle transition. Defects in this gene are a cause of chromosome 9q subtelomeric deletionsyndrome (9q-syndrome). Two transcript variants encoding different isoforms have been found for this gene. (providedby RefSeq, Mar 2009)
UniProtKB/Swiss-Prot: EHMT1_HUMAN, Q9H9B1Function: Histone methyltransferase that specifically mono- and dimethylates 'Lys-9' of histone H3 (H3K9me1 andH3K9me2, respectively) in euchromatin. H3K9me represents a specific tag for epigenetic transcriptional repression byrecruiting HP1 proteins to methylated histones. Also weakly methylates 'Lys-27' of histone H3 (H3K27me). Also requiredfor DNA methylation, the histone methyltransferase activity is not required for DNA methylation, suggesting that these2 activities function independently. Probably targeted to histone H3 by different DNA-binding proteins like E2F6, MGA,MAX and/or DP1. During G0 phase, it probably contributes to silencing of MYC- and E2F-responsive genes, suggesting arole in G0/G1 transition in cell cycle. In addition to the histone methyltransferase activity, also methylatesnon-histone proteins: mediates dimethylation of 'Lys-373' of p53/TP53
|
Genomic Views
for EHMT1 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000009.11 NC_018920.1 NT_024000.16
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the EHMT1 gene promoter:
p53 ATF-2 Pax-2 Pax-2a HNF-4alpha1 CRE-BP1 PPAR-gamma1 Pax-2b c-Myb PPAR-gamma2
Other transcription factors
Search SABiosciences Chromatin IP Primers for EHMT1
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat EHMT1 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 9q34.3 Ensembl cytogenetic band: 9q34.3 HGNC chromosome: 9EHMT1 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 9 GeneLoc Exon Structure GeneLoc location for GC09P140513: view genomic region
(about GC identifiers)
Start:
|
140,513,444 bp from pter |
End:
|
140,764,468 bp from pter |
Size:
|
251,025 bases |
Orientation:
|
plus strand |
|
Proteins
for EHMT1 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: EHMT1_HUMAN, Q9H9B1 (See
protein sequence)Recommended Name: Histone-lysine N-methyltransferase EHMT1 Size: 1298 amino acids; 141466 Da
Subunit: Heterodimer; heterodimerizes with EHMT2/G9a. Interacts with WIZ and EHMT2. Part of the E2F6.com-1 complex inG0 phase composed of E2F6, MGA, MAX, TFDP1, CBX3, BAT8, EHMT1, RING1, RNF2, MBLR, L3MBTL2 and YAF2. Interacts (via ANKrepeats) with RELA (when monomethylated at 'Lys-310'). Interacts with MPHOSPH8
Subcellular location: Nucleus. Chromosome. Note=Associates with euchromatic regions
Sequence caution: Sequence=CAD28534.1; Type=Miscellaneous discrepancy; Note=Intron retention; Sequence=CAH71077.1;Type=Erroneous gene model prediction; Sequence=CAI17354.1; Type=Erroneous gene model prediction;
6/12 PDB 3D structures from  and Proteopedia  for EHMT1 (see all 12):2IGQ (3D)
2RFI (3D)
3B7B (3D)
3B95 (3D)
3FPD (3D)
3HNA (3D)
Secondary accessions: B1AQ58 B1AQ59 Q86X08 Q8TCN7 Q96F53 Q96JF1 Q96KH4Alternative splicing: 4 isoforms: Q9H9B1-1 Q9H9B1-2 Q9H9B1-3 Q9H9B1-4 Explore the universe of human proteins at neXtProt for EHMT1: NX_Q9H9B1
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q9H9B1
EHMT1 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins (2 alternative transcripts):
NP_001138999.1 NP_079033.4
ENSEMBL proteins: ENSP00000417328 ENSP00000417980 ENSP00000436107 ENSP00000334476
Human Recombinant Protein Products for EHMT1:
Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view): About this table
EHMT1 for ontologies About GeneDecksing
EHMT1 Antibody Products:
Assay Products for EHMT1: |
Protein
Domains /
Families
for EHMT1 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
EHMT1 for domains About GeneDecksing
5 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q9H9B1ProtoNet protein and cluster: Q9H9B1 3 Blocks protein families: IPB001214 Nuclear protein SET IPB002110 Ankyrin repeat signature IPB003606 Nuclear protein Zn2+-binding
UniProtKB/Swiss-Prot: EHMT1_HUMAN, Q9H9B1Domain: The ANK repeats recognize and bind RELA subunit of NF-kappa-B, when RELA is monomethylated at 'Lys-310' (Bysimilarity). They also specifically recognize and bind H3K9me1 and H3K9me2Domain: The SET domain mediates interaction with WIZSimilarity: Belongs to the histone-lysine methyltransferase familySimilarity: Contains 8 ANK repeatsSimilarity: Contains 1 pre-SET domainSimilarity: Contains 1 SET domain |
Function
for EHMT1 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
inGenious Targeting Laboratory,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase,
shRNA from
OriGene,
Sirion Biotech,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Sirion Biotech,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
Sirion Biotech,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Molecular Function:
UniProtKB/Swiss-Prot Summary: EHMT1_HUMAN, Q9H9B1Function: Histone methyltransferase that specifically mono- and dimethylates 'Lys-9' of histone H3 (H3K9me1 andH3K9me2, respectively) in euchromatin. H3K9me represents a specific tag for epigenetic transcriptional repression byrecruiting HP1 proteins to methylated histones. Also weakly methylates 'Lys-27' of histone H3 (H3K27me). Also requiredfor DNA methylation, the histone methyltransferase activity is not required for DNA methylation, suggesting that these2 activities function independently. Probably targeted to histone H3 by different DNA-binding proteins like E2F6, MGA,MAX and/or DP1. During G0 phase, it probably contributes to silencing of MYC- and E2F-responsive genes, suggesting arole in G0/G1 transition in cell cycle. In addition to the histone methyltransferase activity, also methylatesnon-histone proteins: mediates dimethylation of 'Lys-373' of p53/TP53Catalytic activity: S-adenosyl-L-methionine + L-lysine-[histone] = S-adenosyl-L-homocysteine +N(6)-methyl-L-lysine-[histone]Enzyme regulation: Methyltransferase activity is inhibited by BIX-01294. Efficiently inhibited by compound E72, aBIX-01294 derivative in which the diazepane ring and the benzyl are replaced with a 3-dimethylaminopropyl and a5-aminopentyl group at sites B and C, respectively Enzyme Numbers (IUBMB): EC 2.1.1.431 EC 2.1.1.-1
Gene Ontology (GO): 5/8 molecular function terms (GO ID links to tree view) (see all 8): About this table
EHMT1 for ontologies About GeneDecksing
Phenotypes:
5 MGI mutant phenotypes (inferred from 3 alleles ) (MGI details for Ehmt1):
EHMT1 for phenotypes About GeneDecksing
Animal Models:
Mouse knock-outs for EHMT1: Ehmt1tm1.2Tara Ehmt1tm1Yshk
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for EHMT1 (see all 8)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for EHMT1 (see all 3)
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector (see all 2): EHMT1 (NM_024757) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for EHMT1 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat EHMT1 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for EHMT1 |
|
Pathways & Interactions
for EHMT1 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | Lysine degradation | |
Pathway sources
See GeneCards unified pathways
Show all pathways
1 
Kegg Pathway (Kegg details for EHMT1):
EHMT1 for pathways About GeneDecksing
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for EHMT1
STRING Interaction
Network Preview (showing 5 interactants - click image to see 25)
5/568 Interacting proteins for EHMT1 (Q9H9B11, 2, 3 ENSP000004179804) via UniProtKB, MINT, STRING, and/or I2D (see all 568)About this table
Gene Ontology (GO): 5/11 biological process terms (GO ID links to tree view) (see all 11): About this table
EHMT1 for ontologies About GeneDecksing
|
Drugs & Compounds
for EHMT1 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Compounds for EHMT1 available from Tocris Bioscience About this table
| Compound | Action |
CAS
# |
|---|
| UNC 0638 | Selective G9a and GLP histone lysine methyltransferase inhibitor | [1255517-77-1] | | BIX 01294 | G9a-like protein and G9a histone lysine methyltransferase (HMTase) inhibitor | [935693-62-2] |
3 HMDB Compounds for EHMT1 About this table
Search CenterWatch for drugs/clinical trials and news about EHMT1
|
Transcripts
for EHMT1 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
Sirion Biotech,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for EHMT1 gene (2 alternative transcripts): NM_001145527.1 NM_024757.4 Unigene Cluster for EHMT1: Euchromatic histone-lysine N-methyltransferase 1 Hs.495511 [show with all ESTs]Unigene Representative Sequence: NM_02475718/19 Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 19): ENST00000462484(uc004coa.3) ENST00000460843(uc011mfc.2) ENST00000371394(uc004cob.1)
ENST00000492232 ENST00000460486 ENST00000495657 ENST00000478940 ENST00000462942
ENST00000465566 ENST00000493484 ENST00000482340 ENST00000486164 ENST00000488242
ENST00000483653 ENST00000494249(uc004coe.3) ENST00000475564 ENST00000472849
ENST00000475704
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for EHMT1 (see all 8)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for EHMT1 (see all 3)
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector (see all 2): EHMT1 (NM_024757) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for EHMT1 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat EHMT1 |
Additional cDNA sequence: AB028932.1 AF461894.1 AK022941.1 AK309602.1 AL713772.1 AL832865.1 AY083210.1 BC011608.2 BC025772.1 BC047504.1 17 DOTS entries: DT.444464 DT.100754667 DT.97844244 DT.97773094 DT.97772087 DT.100754666 DT.121183747 DT.99929894 DT.40228397 DT.75101770 DT.121183727 DT.95320763 DT.99970780 DT.95320741 DT.101956884 DT.121183907 DT.95069933 24/97 AceView cDNA sequences (see all 97): AI522003 AI637854 BQ647702 AW590136 BG757171 BF224311 BU173683 BU185654 BE350686 AI373044 BE504570 CA426038 AI083699 AI092112 AW137187 AW512406 BQ180955 BG149933 AI150350 BQ448180 AW206004 AI521262 BU166398 AW339317
GeneLoc Exon Structure
|
Expression
for EHMT1 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| EHMT1 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TTTATTTTTT
About this image
See EHMT1 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for EHMT1
SOURCE GeneReport for Unigene cluster: Hs.495511
UniProtKB/Swiss-Prot: EHMT1_HUMAN, Q9H9B1Tissue specificity: Widely expressed
SABiosciences Custom PCR Arrays for EHMT1
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for EHMT1
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat EHMT1 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat EHMT1 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat EHMT1 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for EHMT1 |
Orthologs
for EHMT1 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of eukaryotes.
Orthologs for EHMT1 gene from 7/20 species (see all 20) About this table
ENSEMBL Gene Tree for EHMT1 (if available)
TreeFam Gene Tree for EHMT1 (if available) |
Paralogs
for EHMT1 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for EHMT1 gene
- NSD12 EZH12 WHSC12 SUV39H22 WHSC1L12 SETDB22 SETD22 SUV39H12
- EHMT22 EZH22 SETDB12
12 SIMAP similar genes for EHMT1 using alignment to 2 protein entries: EHMT1_HUMAN (see all proteins):FP13812 EHMT2 SUV39H2 IkBa PPP1R12A ZDHHC17
GABPB1 PSMD10 ANKDD1A DKFZp761E1322 MTPN SETMAR
EHMT1 for paralogs About GeneDecksing
|
Genomic Variants
for EHMT1 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 9 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for EHMT1 (140513444 - 140763444 bp, first 250kb of EHMT1)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 14 variations for EHMT1
9 CNVs: 36936 36932 36933 36937 100812 36934 36935 70852 100813
5 Indels: 47679 70851 29113 47681 47680
Human Gene Mutation Database (HGMD): EHMT1
| SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing EHMT1 |
|
Disorders
/ Diseases
for EHMT1 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
EHMT1 for disorders About GeneDecksing
OMIM gene information: 607001
OMIM disorders: 610253
UniProtKB/Swiss-Prot: EHMT1_HUMAN, Q9H9B1
Defects in EHMT1 are the cause of chromosome 9q subtelomeric deletion syndrome (9q- syndrome) [MIM:610253].Common features seen in these patients are severe mental retardation, hypotonia, brachy(micro)cephaly, epilepticseizures, flat face with hypertelorism, synophrys, anteverted nares, cupid bow or tented upper lip, everted lower lip,prognathism, macroglossia, conotruncal heart defects, and behavioral problems
11  diseases for EHMT1: About MalaCardskleefstra syndrome macroglossia intellectual disability fanconi's anemia
hypotonia anemia homocysteine colorectal cancer
breast cancer esophagitis adenocarcinoma
1 disease from the University of Copenhagen DISEASES database for EHMT1:Intellectual disability Human Genome Epidemiology (HuGE) Navigator: EHMT1 (8 documents)
Export disorders for EHMT1 gene to outside databases
|
Publications
for EHMT1 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for EHMT1 gene, integrated from 9 sources (see all 63):
(articles sorted by number of sources associating them with EHMT1) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- A complex with chromatin modifiers that occupies E2F- and Myc- responsive genes in G0 cells. (PubMed id 12004135)1, 2, 3 Ogawa H.... Nakatani Y. (2002)
- Prediction of the coding sequences of unidentified human genes. XX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 11347906)1, 2, 3 Nagase T.... Ohara O. (2001)
- G9a and Glp methylate lysine 373 in the tumor suppres sor p53. (PubMed id 20118233)1, 2, 9 Huang J....Berger S.L. (2010)
- The ankyrin repeats of G9a and GLP histone methyltransferases are mono- and dimethyllysine binding modules. (PubMed id 18264113)1, 2, 9 Collins R.E....Cheng X. (2008)
- Structural biology of human H3K9 methyltransferases. (PubMed id 20084102)1, 2 Wu H....Schapira M. (2010)
- Zinc finger protein Wiz links G9a/GLP histone methyltransferases to the co-repressor molecule CtBP. (PubMed id 16702210)1, 2 Ueda J.... Shinkai Y. (2006)
- Loss-of-function mutations in euchromatin histone methyl transferase 1 (EHMT1) cause the 9q34 subtelomeric deletion syndrome. (PubMed id 16826528)1, 2 Kleefstra T.... van Bokhoven H. (2006)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones. (PubMed id 12168954)1, 2 Nakajima D.... Nagase T. (2002)
|
External Searches for EHMT1 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing EHMT1 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing EHMT1 gene
(According to HUGE)
About This Section
| |
Specialized Databases showing EHMT1 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for EHMT1 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for EHMT1 gene:
Search GeneIP for patents involving EHMT1
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for EHMT1 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory)
About This Section
|
 | |
 | |
 |
| | |  | OriGene Antibodies for EHMT1 | | OriGene shRNA RFP for EHMT1 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for EHMT1 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for EHMT1 | | | OriGene Protein Over-expression Lysate for EHMT1 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for EHMT1 | | OriGene 3'-UTR Clone for EHMT1 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for EHMT1 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for EHMT1 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for EHMT1 | | OriGene Custom Protein Services for EHMT1 | | | OriGene Custom Immunoassay Development | | |
| |
 |
 |
| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat EHMT1 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing EHMT1 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat EHMT1 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat EHMT1 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat EHMT1 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat EHMT1 |
| |
 |  |  |  | |
| | | | Tocris compounds for EHMT1 |
| |  |  |  |  | | | | |
 |
 |
 |
 | | | EHMT1 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for EHMT1 |
|  |  |  |  | | | | ThermoFisher Antibodies for EHMT1 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat EHMT1 |
| |  | |
|
|
|
