Aliases for EHMT1 Gene
Aliases for EHMT1 Gene
External Ids for EHMT1 Gene
- HGNC: 24650
- Entrez Gene: 79813
- Ensembl: ENSG00000181090
- OMIM: 607001
- UniProtKB: Q9H9B1
Previous GeneCards Identifiers for EHMT1 Gene
- GC09P135825
- GC09P137881
- GC09P139633
- GC09P139725
- GC09P140513
- GC09P110067
Summaries for EHMT1 Gene
-
The protein encoded by this gene is a histone methyltransferase that is part of the E2F6 complex, which represses transcription. The encoded protein methylates the Lys-9 position of histone H3, which tags it for transcriptional repression. This protein may be involved in the silencing of MYC- and E2F-responsive genes and therefore could play a role in the G0/G1 cell cycle transition. Defects in this gene are a cause of chromosome 9q subtelomeric deletion syndrome (9q-syndrome, also known as Kleefstra syndrome). Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2014]
GeneCards Summary for EHMT1 Gene
EHMT1 (Euchromatic Histone-Lysine N-Methyltransferase 1) is a Protein Coding gene. Diseases associated with EHMT1 include Kleefstra Syndrome and Alcohol Dependence. Among its related pathways are Gene Expression and Regulation of TP53 Activity. GO annotations related to this gene include methyltransferase activity and histone-lysine N-methyltransferase activity. An important paralog of this gene is SETDB1.
UniProtKB/Swiss-Prot for EHMT1 Gene
-
Histone methyltransferase that specifically mono- and dimethylates Lys-9 of histone H3 (H3K9me1 and H3K9me2, respectively) in euchromatin. H3K9me represents a specific tag for epigenetic transcriptional repression by recruiting HP1 proteins to methylated histones. Also weakly methylates Lys-27 of histone H3 (H3K27me). Also required for DNA methylation, the histone methyltransferase activity is not required for DNA methylation, suggesting that these 2 activities function independently. Probably targeted to histone H3 by different DNA-binding proteins like E2F6, MGA, MAX and/or DP1. During G0 phase, it probably contributes to silencing of MYC- and E2F-responsive genes, suggesting a role in G0/G1 transition in cell cycle. In addition to the histone methyltransferase activity, also methylates non-histone proteins: mediates dimethylation of Lys-373 of p53/TP53.
-
Lysine methyltransferases are enyzmes that catalyze the transfer of methyl groups from S-adenosylmethionine (SAM) to the lysine residues on histones, particularly histones H3 and H4. The dysregulation of this methylation is critical in the development of cancer.
No data available for Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for EHMT1 Gene
Genomics for EHMT1 Gene
Regulatory Elements for EHMT1 Gene
Enhancers for EHMT1 Gene
| GeneHancer Identifier | Score | Enhancer Sources | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites within enhancer | Other Gene Targets for Enhancer |
|---|
Enhancers around EHMT1 on UCSC Golden Path with GeneCards custom track
Promoters for EHMT1 Gene
| Ensembl Regulatory Elements (ENSRs) | TSS Distance (bp) | Size (bp) | Binding Sites for Transcription Factors within promoters |
|---|
ENSRs around EHMT1 on UCSC Golden Path with GeneCards custom track
- Transcription factor binding sites by QIAGEN in the EHMT1 gene promoter:
Regulatory Element Products
Genomic Location for EHMT1 Gene
- Chromosome:
- 9
- Start:
- 137,618,963 bp from pter
- End:
- 137,870,016 bp from pter
- Size:
- 251,054 bases
- Orientation:
- Plus strand
Genomic View for EHMT1 Gene
Genes around EHMT1 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 9q34.3 by Ensembl
- 9q34.3 by Entrez Gene
- 9q34.3 by HGNC
EHMT1 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for EHMT1 Gene
Proteins for EHMT1 Gene
-
Protein details for EHMT1 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q9H9B1-EHMT1_HUMAN
- Recommended name:
- Histone-lysine N-methyltransferase EHMT1
- Protein Accession:
- Q9H9B1
- B1AQ58
- B1AQ59
- Q86X08
- Q8TCN7
- Q96F53
- Q96JF1
- Q96KH4
Protein attributes for EHMT1 Gene
- Size:
- 1298 amino acids
- Molecular mass:
- 141466 Da
- Quaternary structure:
-
- Heterodimer; heterodimerizes with EHMT2. Interacts with WIZ and EHMT2. Part of the E2F6.com-1 complex in G0 phase composed of E2F6, MGA, MAX, TFDP1, CBX3, BAT8, EHMT1, RING1, RNF2, MBLR, L3MBTL2 and YAF2. Interacts (via ANK repeats) with RELA (when monomethylated at Lys-310). Interacts with MPHOSPH8. Interacts with CDYL. Interacts with REST only in the presence of CDYL. Part of a complex containing at least CDYL, REST, WIZ, SETB1, EHMT1 and EHMT2.
- SequenceCaution:
-
- Sequence=BAB14321.1; Type=Erroneous translation; Note=Wrong choice of CDS.; Evidence={ECO:0000305}; Sequence=CAD28534.1; Type=Miscellaneous discrepancy; Note=Intron retention.; Evidence={ECO:0000305}; Sequence=CAH71077.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=CAI17354.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
Three dimensional structures from OCA and Proteopedia for EHMT1 Gene
Protein Expression for EHMT1 Gene
Post-translational modifications for EHMT1 Gene
Other Protein References for EHMT1 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- EMD Millipore Complete listing of Mono and Polychlonal Antibodies for EHMT1
- R&D Systems Antibodies for EHMT1 (GLP/EHMT1)
- Novus Biologicals Antibodies for EHMT1
- Abcam antibodies for EHMT1/GLP
- Invitrogen Antibodies for EHMT1
- antibodies-online Antibodies for EHMT1: See all 551
- GeneTex EHMT1 antibody for EHMT1
-
Santa Cruz Biotechnology (SCBT) Antibodies for EHMT1
Protein Products
-
OriGene Purified Proteins for EHMT1
- Search Origene for MassSpec and Protein Over-expression Lysates for EHMT1
- Origene Custom Protein Services for EHMT1
- antibodies-online Proteins for EHMT1: See all 72
- Search antibodies-online for peptides
- Search GeneTex for Proteins for EHMT1
Assay Products
- antibodies-online Kits for EHMT1: See all 202
No data available for DME Specific Peptides for EHMT1 Gene
Domains & Families for EHMT1 Gene
Gene Families for EHMT1 Gene
Protein Domains for EHMT1 Gene
Suggested Antigen Peptide Sequences for EHMT1 Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
Q9H9B1UniProtKB/Swiss-Prot:
EHMT1_HUMAN :- The ANK repeats recognize and bind RELA subunit of NF-kappa-B, when RELA is monomethylated at Lys-310 (By similarity). They also specifically recognize and bind H3K9me1 and H3K9me2.
- Belongs to the class V-like SAM-binding methyltransferase superfamily.
- Contains 8 ANK repeats.
- Domain:
-
- The ANK repeats recognize and bind RELA subunit of NF-kappa-B, when RELA is monomethylated at Lys-310 (By similarity). They also specifically recognize and bind H3K9me1 and H3K9me2.
- The SET domain mediates interaction with WIZ.
- In the pre-SET domain, Cys residues bind 3 zinc ions that are arranged in a triangular cluster; some of these Cys residues contribute to the binding of two zinc ions within the cluster.
- Contains 1 pre-SET domain.
- Contains 1 SET domain.
- Family:
-
- Belongs to the class V-like SAM-binding methyltransferase superfamily.
- Similarity:
-
- Contains 8 ANK repeats.
Function for EHMT1 Gene
Molecular function for EHMT1 Gene
- UniProtKB/Swiss-Prot CatalyticActivity:
- S-adenosyl-L-methionine + L-lysine-[histone] = S-adenosyl-L-homocysteine + N(6)-methyl-L-lysine-[histone].
- UniProtKB/Swiss-Prot EnzymeRegulation:
- Methyltransferase activity is inhibited by BIX-01294. Efficiently inhibited by compound E72, a BIX-01294 derivative in which the diazepane ring and the benzyl are replaced with a 3-dimethylaminopropyl and a 5-aminopentyl group at sites B and C, respectively.
- UniProtKB/Swiss-Prot Function:
- Histone methyltransferase that specifically mono- and dimethylates Lys-9 of histone H3 (H3K9me1 and H3K9me2, respectively) in euchromatin. H3K9me represents a specific tag for epigenetic transcriptional repression by recruiting HP1 proteins to methylated histones. Also weakly methylates Lys-27 of histone H3 (H3K27me). Also required for DNA methylation, the histone methyltransferase activity is not required for DNA methylation, suggesting that these 2 activities function independently. Probably targeted to histone H3 by different DNA-binding proteins like E2F6, MGA, MAX and/or DP1. During G0 phase, it probably contributes to silencing of MYC- and E2F-responsive genes, suggesting a role in G0/G1 transition in cell cycle. In addition to the histone methyltransferase activity, also methylates non-histone proteins: mediates dimethylation of Lys-373 of p53/TP53.
Enzyme Numbers (IUBMB) for EHMT1 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0002039 | p53 binding | IPI | 20118233 |
| GO:0008168 | methyltransferase activity | IDA | 12004135 |
| GO:0016279 | protein-lysine N-methyltransferase activity | IDA | 20118233 |
| GO:0070742 | C2H2 zinc finger domain binding | IEA | -- |
Phenotypes for EHMT1 Gene
- MGI mutant phenotypes for EHMT1:
- inferred from 5 alleles
- GenomeRNAi human phenotypes for EHMT1:
Animal Models for EHMT1 Gene
Animal Model Products
-
Taconic Biosciences Mouse Models for EHMT1
-
ViGene Biosciences lentiviral particle packaged cDNA for EHMT1 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for EHMT1 gene
- Search ViGene Biosciences for EHMT1
CRISPR Products
-
OriGene CRISPR knockouts for EHMT1
-
Santa Cruz Biotechnology (SCBT) CRISPR for EHMT1
- GenScript: Design CRISPR guide RNA sequences for EHMT1
miRNA for EHMT1 Gene
- miRTarBase miRNAs that target EHMT1
miRNA Products
- Search ViGene Biosciences for EHMT1
Clone Products
- OriGene clones in human for EHMT1
- OriGene ORF clones in human,mouse,rat for EHMT1
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
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Cell Line Products
-
ViGene Biosciences adenoviral particle packaged cDNA for EHMT1 gene
-
ViGene Biosciences lentiviral particle packaged cDNA for EHMT1 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for EHMT1 gene
Flow Cytometry Products
No data available for Transcription Factor Targets and HOMER Transcription for EHMT1 Gene
Localization for EHMT1 Gene
Subcellular locations from UniProtKB/Swiss-Prot for EHMT1 Gene
- Nucleus. Chromosome. Note=Associates with euchromatic regions.
| Compartment | Confidence |
|---|---|
| nucleus | 5 |
| cytosol | 3 |
| plasma membrane | 2 |
No data available for Gene Ontology (GO) - Cellular Components for EHMT1 Gene
Pathways & Interactions for EHMT1 Gene
More details on SuperPathways for EHMT1| Superpath | Contained pathways | ||
|---|---|---|---|
| 1 | Cellular Senescence | ||
| 2 | Regulation of TP53 Activity | ||
| 3 | Chromatin organization | ||
| 4 | Gene Expression |
.49
|
|
| 5 | Longevity regulating pathway - multiple species |
Pathways by source for EHMT1 Gene
1 GeneTex pathway for EHMT1 Gene
11 Reactome pathways for EHMT1 Gene
2 KEGG pathways for EHMT1 Gene
1 R&D Systems pathway for EHMT1 Gene
Interacting Proteins for EHMT1 Gene
Selected Interacting proteins:
Q9H9B1-EHMT1_HUMAN
ENSP00000417980
for EHMT1 Gene via
MINT
STRING
UniProtKB
I2D
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000122 | negative regulation of transcription from RNA polymerase II promoter | IEA | -- |
| GO:0006306 | DNA methylation | ISS | -- |
| GO:0006325 | chromatin organization | TAS | -- |
| GO:0009790 | embryo development | ISS | -- |
| GO:0016568 | chromatin modification | IDA | 12004135 |
No data available for SIGNOR curated interactions for EHMT1 Gene
Drugs & Compounds for EHMT1 Gene
| Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
|---|---|---|---|---|---|---|
| Entacapone | Approved, Investigational | Pharma | COMT inhibitor, Potent COMT inhibitor; blocks alpha-synuclein aggregation | 48 | ||
| L-Lysine | Approved | Nutra | Full agonist, Agonist | 0 | ||
| S-Adenosylmethionine | Approved | Nutra | 0 | |||
| s-adenosylhomocysteine | Experimental | Pharma | 0 | |||
| EPZ004777 | Pharma | DOT1L inhibitor | 0 |
| Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs | |
|---|---|---|---|---|---|---|
| C 21 |
|
1229236-78-5 |
|
|
||
| Furamidine dihydrochloride |
|
55368-40-6 |
|
|
||
| SGC 707 |
|
|
|
|||
| TC-E 5003 |
|
17328-16-4 |
|
|
||
| UNC 2327 |
|
1426152-53-5 |
|
|
(5) Tocris Compounds for EHMT1 Gene
| Compound | Action | Cas Number |
|---|---|---|
| C 21 | Selective PRMT1 inhibitor | 1229236-78-5 |
| Furamidine dihydrochloride | Selective PRMT1 inhibitor | 55368-40-6 |
| SGC 707 | Potent and selective allosteric inhibitor of PRMT3 | |
| TC-E 5003 | Selective PRMT1 inhibitor | 17328-16-4 |
| UNC 2327 | Allosteric inhibitor of PRMT3 | 1426152-53-5 |
(5) ApexBio Compounds for EHMT1 Gene
| Compound | Action | Cas Number |
|---|---|---|
| Entacapone | COMT inhibitor | 130929-57-6 |
| EPZ004777 | DOT1L inhibitor | 1338466-77-5 |
| PFI-2 | 1627676-59-8 | |
| SGI-1027 | DNMT inhibitor | 1020149-73-8 |
| UNC 0631 | G9a inhibitor | 1320288-19-4 |
Drug Products
- ApexBio compounds for EHMT1
Transcripts for EHMT1 Gene
mRNA/cDNA for EHMT1 Gene
- (18) REFSEQ mRNAs :
- (10) Additional mRNA sequences :
- (97) Selected AceView cDNA sequences:
- (23) Ensembl transcripts including schematic representations, and UCSC links where relevant :
Unigene Clusters for EHMT1 Gene
CRISPR Products
-
OriGene CRISPR knockouts for EHMT1
-
Santa Cruz Biotechnology (SCBT) CRISPR for EHMT1
- GenScript: Design CRISPR guide RNA sequences for EHMT1
miRNA Products
- Search ViGene Biosciences for EHMT1
Clone Products
- OriGene clones in human for EHMT1
- OriGene ORF clones in human,mouse,rat for EHMT1
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- Addgene plasmids for EHMT1
Flow Cytometry Products
Expression for EHMT1 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
-
Epiblast (Early Embryonic Tissues)
- Primordial Germ Cell Precursors Epiblast
-
Gonad
- Primordial Germ Cell Precursors Epiblast
-
Spleen (Hematopoietic System)
This gene is overexpressed in Peripheral blood mononuclear cells (16.7), Lung (7.5), and CD8 Tcells (6.1).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for EHMT1 Gene
SOURCE GeneReport for Unigene cluster for EHMT1 Gene Hs.495511
mRNA Expression by UniProt/SwissProt for EHMT1 Gene
Q9H9B1-EHMT1_HUMAN
Tissue specificity:
Widely expressed.
- Elite partner
Primer Products
-
OriGene qPCR primer pairs for EHMT1
No data available for mRNA differential expression in normal tissues for EHMT1 Gene
Orthologs for EHMT1 Gene
This gene was present in the common ancestor of animals.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| cow (Bos Taurus) |
Mammalia | EHMT1 35 |
|
||
| EHMT1 36 |
|
OneToOne | |||
| dog (Canis familiaris) |
Mammalia | EHMT1 35 |
|
||
| EHMT1 36 |
|
OneToOne | |||
| mouse (Mus musculus) |
Mammalia | Ehmt1 35 |
|
||
| Ehmt1 16 |
|
||||
| Ehmt1 36 |
|
OneToOne | |||
| chimpanzee (Pan troglodytes) |
Mammalia | EHMT1 35 |
|
||
| EHMT1 36 |
|
OneToOne | |||
| rat (Rattus norvegicus) |
Mammalia | Ehmt1 35 |
|
||
| oppossum (Monodelphis domestica) |
Mammalia | EHMT1 36 |
|
OneToOne | |
| platypus (Ornithorhynchus anatinus) |
Mammalia | EHMT1 36 |
|
OneToOne | |
| chicken (Gallus gallus) |
Aves | EHMT1 35 |
|
||
| EHMT1 36 |
|
OneToOne | |||
| lizard (Anolis carolinensis) |
Reptilia | EHMT1 36 |
|
OneToOne | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | ehmt1 35 |
|
||
| zebrafish (Danio rerio) |
Actinopterygii | ehmt1b 35 |
|
||
| ehmt1a 36 |
|
OneToMany | |||
| ehmt1b 36 |
|
OneToMany | |||
| fruit fly (Drosophila melanogaster) |
Insecta | G9a 36 |
|
OneToMany | |
| sea squirt (Ciona savignyi) |
Ascidiacea | CSA.117 36 |
|
OneToMany |
- Species with no ortholog for EHMT1:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
- worm (Caenorhabditis elegans)
Paralogs for EHMT1 Gene
Paralogs for EHMT1 Gene
(12) SIMAP similar genes for EHMT1 Gene using alignment to 2 proteins:
Variants for EHMT1 Gene
| SNP ID | Clin | Chr 09 pos | Sequence Context | AA Info | Type |
|---|---|---|---|---|---|
| rs11137198 | - | 137,744,082(+) | ATCGC(A/C/G)CCCAG | reference, missense | |
| VAR_036345 | A breast cancer sample | ||||
| VAR_036346 | A breast cancer sample | ||||
| VAR_069183 | Kleefstra syndrome (KLESTS) | ||||
| rs975978 | -- | 137,692,704(+) | GTCAG(A/G)AGCAC | intron-variant |
Residual Variation Intolerance Score:
1.73% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
4.19;
61.87% of all genes are more intolerant (likely to be disease-causing)
Relevant External Links for EHMT1 Gene
- Human Gene Mutation Database (HGMD)
- EHMT1
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for EHMT1 Gene
Disorders for EHMT1 Gene
(5) MalaCards diseases for EHMT1 Gene - From: OMIM, ClinVar, GeneTests, Orphanet, Swiss-Prot, DISEASES, and GeneCards
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| kleefstra syndrome |
|
|
| alcohol dependence |
|
|
| kleefstra syndrome due to a point mutation |
|
|
| kleefstra syndrome due to 9q34 microdeletion |
|
|
| hypoplastic left heart syndrome |
|
|
Search EHMT1 in MalaCards
View complete list of genes associated with diseases
UniProtKB/Swiss-Prot
EHMT1_HUMAN- Kleefstra syndrome (KLESTS) [MIM:610253]: A syndrome characterized by severe mental retardation, hypotonia, brachy(micro)cephaly, and facial dysmorphisms. Additionally, congenital heart defects, urogenital defects, epilepsy and behavioral problems are frequently observed. {ECO:0000269 PubMed:16826528, ECO:0000269 PubMed:19264732}. Note=The disease is caused by mutations affecting the gene represented in this entry (PubMed:16826528). The syndrome can be either caused by intragenic EHMT1 mutations leading to haploinsufficiency of the EHMT1 gene or by a submicroscopic 9q34.3 deletion. Although it is not known if and to what extent other genes in the 9q34.3 region contribute to the syndrome observed in deletion cases, EHMT1 seems to be the major determinant of the core disease phenotype (PubMed:19264732). {ECO:0000269 PubMed:16826528, ECO:0000269 PubMed:19264732}.
Relevant External Links for EHMT1
No data available for Genatlas for EHMT1 Gene
Publications for EHMT1 Gene
- A complex with chromatin modifiers that occupies E2F- and Myc- responsive genes in G0 cells. (PMID: 12004135) Ogawa H. … Nakatani Y. (Science 2002) 2 3 4 67
- G9a and Glp methylate lysine 373 in the tumor suppressor p53. (PMID: 20118233) Huang J. … Berger S.L. (J. Biol. Chem. 2010) 3 23
- A jumonji (Jarid2) protein complex represses cyclin D1 expression by methylation of histone H3-K9. (PMID: 19010785) Shirato H. … Takeuchi T. (J. Biol. Chem. 2009) 3 23
- Distinct roles for histone methyltransferases G9a and GLP in cancer germ-line antigen gene regulation in human cancer cells and murine embryonic stem cells. (PMID: 19531572) Link P.A. … Karpf A.R. (Mol. Cancer Res. 2009) 3 23
- The ankyrin repeats of G9a and GLP histone methyltransferases are mono-and dimethyllysine binding modules. (PMID: 18264113) Collins R.E. … Cheng X. (Nat. Struct. Mol. Biol. 2008) 3 23
Products for EHMT1 Gene
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- Taconic Biosciences Mouse Models for EHMT1
- Find your next knockout model in the Taconic Knockout Repository
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- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
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- antibodies-online Antibodies for EHMT1: See all 551
- antibodies-online Kits for EHMT1: See all 202
- antibodies-online Proteins for EHMT1: See all 72
- Search antibodies-online for peptides
- GeneTex EHMT1 antibody for EHMT1
- Search GeneTex for Proteins for EHMT1
- ViGene Biosciences adenoviral particle packaged cDNA for EHMT1 gene
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- Search ViGene Biosciences for EHMT1
- Search ViGene Biosciences for EHMT1
- Santa Cruz Biotechnology (SCBT) Antibodies for EHMT1
- Search Santa Cruz Biotechnology (SCBT) for EHMT1 siRNA/shRNA
- Santa Cruz Biotechnology (SCBT) CRISPR for EHMT1
Sources for EHMT1 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) I2D
- (22) IntAct
- (23) Novoseek
- (24) PharmGKB
- (25) DrugBank
- (26) HMDB
- (27) UniGene
- (28) AceView
- (29) RNAdb
- (30) ASD
- (31) ECgene
- (32) GeneAnnot
- (33) SAGE
- (34) SOURCE
- (35) HomoloGene
- (36) PanEnsembl
- (37) euGenes
- (38) SGD
- (39) FlyBase
- (40) WormBase
- (41) Pseudogene
- (42) DGV
- (43) dbSNP
- (44) HapMap
- (45) GenAtlas
- (46) GeneTests
- (47) HGMD
- (48) GAD
- (49) LSDB
- (50) BGMUT
- (51) HuGE
- (52) eBioscience
- (53) Atlas
- (54) Cell Signaling Technology
- (55) GenBank
- (56) H-invDB
- (57) HORDE
- (58) HUGE
- (59) IMGT
- (60) Leiden
- (61) MILLIPORE
- (62) miRBase
- (63) DME
- (64) Nature
- (65) NCBI
- (66) OriGene
- (67) PubMed
- (68) R&D Systems
- (69) Salk
- (70) TGDB
- (71) Tufts
- (72) YEDA
- (73) CROW21
- (74) Tocris
- (75) Abcam
- (76) Novus
- (77) ProSpec
- (78) Sino Biological
- (79) GenScript
- (80) Qiagen
- (81) Cloud-Clone Corp.
- (82) Enzo Life Sciences
- (83) OCA
- (84) Proteopedia
- (85) MOPED
- (86) SPIRE
- (87) neXtProt
- (88) Reactome
- (89) GeneGo (Thomson Reuters)
- (90) fRNAdb
- (91) DISEASES
- (92) SIMAP
- (93) GenomeRNAi
- (94) LifeMap
- (95) miRTarBase
- (96) MalaCards
- (97) Invitrogen
- (98) BitterDB
- (99) Vector BioLabs
- (100) ESI-BIO
- (101) RefSeq
- (102) BioSystems
- (103) MaxQB
- (104) IUPHAR
- (105) BioGPS
- (106) Illumina
- (107) COMPARTMENTS
- (108) HOMER
- (109) PaxDb
- (110) ApexBio
- (111) Addgene
- (112) Advanced Cell Diagnostics
- (113) antibodies-online
- (114) CYP
- (115) NONCODE
- (116) SwitchGear Genomics
- (117) TreeFam
- (118) PathCards
- (119) GeneReviews
- (120) GeneTex
- (121) Taconic Biosciences
- (122) GTEx
- (123) ProteomicsDB
- (124) SCBT
- (125) DGIdb
- (126) ClinicalTrials
- (127) FDA Approved Drugs
- (128) RVIS
- (129) SIGNOR
- (130) diseasecard
- (131) NIH Rare Diseases
- (132) Orphanet
- (133) UMLS
- (134) GTR
- (135) Disease Ontology
- (136) Genetics Home Reference
- (137) MeSH
- (138) MedlinePlus
- (139) CDC
- (140) NINDS
- (141) NCBI Bookshelf
- (142) ClinVar
- (143) Gene Damage Index
- (144) ViGene Biosciences
- (145) HPO
- (146) UDN
- (147) VISTA
- (148) FANTOM5
- (149) ENCODE
- (150) ProSci
- (151) Horizon