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EHF Gene

protein-coding   GIFtS: 61
GCID: GC11P034599

Ets Homologous Factor

  See EHF-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Ets Homologous Factor1 2     ESEJ2 3
ESE32 3 5     ETS Domain-Containing Transcription Factor2 3
ESE3 Transcription Factor1 2     hEHF2 3
Epithelium-Specific Ets Transcription Factor 32 3     Epithelium-Specific Ets Factor 31
ESE3B2 3     ESE-33

External Ids:    HGNC: 32461   Entrez Gene: 262982   Ensembl: ENSG000001353737   OMIM: 6054395   UniProtKB: Q9NZC43   

Export aliases for EHF gene to outside databases

Previous GC identifers: GC11P036195 GC11P035320 GC11P034681 GC11P034606 GC11P034339


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for EHF Gene:
This gene encodes a protein that belongs to an ETS transcription factor subfamily characterized by
epithelial-specific expression (ESEs). The encoded protein acts as a transcriptional repressor and may be
involved in epithelial differentiation and carcinogenesis. Three transcript variants encoding different isoforms
have been found for this gene. (provided by RefSeq, Jun 2011)

GeneCards Summary for EHF Gene:
EHF (ets homologous factor) is a protein-coding gene. Diseases associated with EHF include vertebrobasilar insufficiency, and allergic urticaria. GO annotations related to this gene include sequence-specific DNA binding and sequence-specific DNA binding transcription factor activity. An important paralog of this gene is ELK4.

UniProtKB/Swiss-Prot: EHF_HUMAN, Q9NZC4
Function: Transcriptional activator that may play a role in regulating epithelial cell differentiation and
proliferation. May act as a repressor for a specific subset of ETS/AP-1-responsive genes and as a modulator of
the nuclear response to mitogen-activated protein kinase signaling cascades. Binds to DNA sequences containing
the consensus nucleotide core sequence GGAA. Involved in regulation of TNFRSF10B/DR5 expression through
Ets-binding sequences on the TNFRSF10B/DR5 promoter. May contribute to development and carcinogenesis by acting
as a tumor suppressor gene or anti-oncogene

Gene Wiki entry for EHF Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000011.9  NT_009237.19  NC_018922.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the EHF gene promoter:
         Bach2   FOXD1   Ik-3   Evi-1   Roaz   GATA-2   GATA-1   AREB6   POU2F1   POU2F1a   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidEHF promoter sequence
   Search Chromatin IP Primers for EHF

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat EHF


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11p12   Ensembl cytogenetic band:  11p13   HGNC cytogenetic band: 11p12

EHF Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
EHF gene location

GeneLoc information about chromosome 11         GeneLoc Exon Structure

GeneLoc location for GC11P034599:  view genomic region     (about GC identifiers)

Start:
34,642,588 bp from pter      End:
34,684,835 bp from pter
Size:
42,248 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: EHF_HUMAN, Q9NZC4 (See protein sequence)
Recommended Name: ETS homologous factor  
Size: 300 amino acids; 34892 Da
Secondary accessions: D3DR08 D3DR10 E9PSB2 Q9H509 Q9UKF9 Q9Y5V4 Q9Y5V5
Alternative splicing: 3 isoforms:  Q9NZC4-1   Q9NZC4-2   Q9NZC4-3   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for EHF: NX_Q9NZC4

Explore proteomics data for EHF at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See EHF Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (3 alternative transcripts): 
    NP_001193544.1  NP_001193545.1  NP_036285.2  

    ENSEMBL proteins: 
     ENSP00000257831   ENSP00000399733   ENSP00000433508   ENSP00000435837   ENSP00000432905  
     ENSP00000436357   ENSP00000434395   ENSP00000435835   ENSP00000432460   ENSP00000436158  

    EHF Human Recombinant Protein Products:

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    Novus Biologicals EHF Proteins
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    ProSpec Recombinant Protein for EHF
    Cloud-Clone Corp. Proteins for EHF

     
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    EHF Assay Products:

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    4 InterPro protein domains:
     IPR011991 WHTH_DNA-bd_dom
     IPR003118 Pointed_dom
     IPR013761 SAM/pointed
     IPR000418 Ets_dom

    Graphical View of Domain Structure for InterPro Entry Q9NZC4

    ProtoNet protein and cluster: Q9NZC4

    1 Blocks protein domain: IPB003118 Sterile alpha motif (SAM)/Pointed domain

    UniProtKB/Swiss-Prot: EHF_HUMAN, Q9NZC4
    Domain: The PNT domain acts as a transcriptional activator (By similarity)
    Similarity: Belongs to the ETS family
    Similarity: Contains 1 ETS DNA-binding domain
    Similarity: Contains 1 PNT (pointed) domain


    Find genes that share domains with EHF           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: EHF_HUMAN, Q9NZC4
    Function: Transcriptional activator that may play a role in regulating epithelial cell differentiation and
    proliferation. May act as a repressor for a specific subset of ETS/AP-1-responsive genes and as a modulator of
    the nuclear response to mitogen-activated protein kinase signaling cascades. Binds to DNA sequences containing
    the consensus nucleotide core sequence GGAA. Involved in regulation of TNFRSF10B/DR5 expression through
    Ets-binding sequences on the TNFRSF10B/DR5 promoter. May contribute to development and carcinogenesis by acting
    as a tumor suppressor gene or anti-oncogene
    Induction: By IL1B/interleukin-1 beta and TNF in bronchial smooth muscle cells and fibroblasts. By
    IL10/interleukin-10 and IFNG/IFN-gamma in monocyte-derived dendritic cells

         Genatlas biochemistry entry for EHF:
    ETS homologous factor,ETS transcription regulator family,differentially expressed in normal tissues and
    carcinomas,noteworthy in carcinomas associated with an 11p12 deletion (see TSG11G) repressing ETS2 induced
    activity of stromelysin 1 (MMP3) and collagenase 1 (MMP8) promoters

         Gene Ontology (GO): 4 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000981sequence-specific DNA binding RNA polymerase II transcription factor activity IBA--
    GO:0003677DNA binding TAS10527851
    GO:0003700sequence-specific DNA binding transcription factor activity IDA10644770
    GO:0043565sequence-specific DNA binding IEA--
         
    Find genes that share ontologies with EHF           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for EHF:
     Synthetic lethal with imatinib 

    Animal Models:
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for EHF
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for EHF

    Transcription Factor Targeting: 
    Targeting motifs: HOMER Transcription Factor Regulatory Elements motif viewer 
                                          Consensus sequence:  AVCAGGAAGT 

    miRNA
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    miRTarBase miRNAs that target EHF:
    hsa-mir-335-5p (MIRT017515)

    Block miRNA regulation of human, mouse, rat EHF using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate EHF (see all 70):
    hsa-miR-607 hsa-miR-361-5p hsa-miR-146a hsa-miR-128 hsa-miR-3074-3p hsa-miR-342-3p hsa-miR-3613-3p hsa-miR-29a*
    SwitchGear 3'UTR luciferase reporter plasmidEHF 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat EHF

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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    EHF_HUMAN, Q9NZC4: Nucleus
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    cytosol3
    extracellular1
    mitochondrion1

    Gene Ontology (GO): 1 cellular component term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IC10644770

    Find genes that share ontologies with EHF           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for EHF
    Interactions:

        GeneGlobe Interaction Network for EHF

    STRING Interaction Network Preview (showing 5 interactants - click image to see 10)

    Selected Interacting proteins for EHF (Q9NZC42, 3 ENSP000002578314) via UniProtKB, MINT, STRING, and/or I2D (see all 10)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    FRZBQ927652, 3, ENSP000002951134MINT-8255459 I2D: score=2 STRING: ENSP00000295113
    NFKBIZQ9BYH83, ENSP000003256634I2D: score=1 STRING: ENSP00000325663
    ELF3P785453, ENSP000003526734I2D: score=2 STRING: ENSP00000352673
    NFKBIDENSP000003801094STRING: ENSP00000380109
    UBE2SENSP000002645524STRING: ENSP00000264552
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006351transcription, DNA-templated ----
    GO:0006355regulation of transcription, DNA-templated ----
    GO:0006357regulation of transcription from RNA polymerase II promoter IBA--
    GO:0006366transcription from RNA polymerase II promoter IBA--
    GO:0007275multicellular organismal development TAS10644770

    Find genes that share ontologies with EHF           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for EHF



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for EHF gene (3 alternative transcripts): 
    NM_001206615.1  NM_001206616.1  NM_012153.5  

    Unigene Cluster for EHF:

    Ets homologous factor
    Hs.653859  [show with all ESTs]
    Unigene Representative Sequence: NM_001206616
    12 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000527001 ENST00000257831(uc001mvr.2 uc009yke.2 uc009ykf.2 uc021qfu.1)
    ENST00000450654 ENST00000530286 ENST00000533754 ENST00000529527 ENST00000531728
    ENST00000525253 ENST00000531794 ENST00000529161 ENST00000532302 ENST00000527935

    miRNA
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    Block miRNA regulation of human, mouse, rat EHF using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate EHF (see all 70):
    hsa-miR-607 hsa-miR-361-5p hsa-miR-146a hsa-miR-128 hsa-miR-3074-3p hsa-miR-342-3p hsa-miR-3613-3p hsa-miR-29a*
    SwitchGear 3'UTR luciferase reporter plasmidEHF 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat EHF
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    OriGene ORF clones in mouse, rat for EHF
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    GenScript: all cDNA clones in your preferred vector (see all 3): EHF (NM_012153)
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    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat EHF
      QuantiTect SYBR Green Assays in human, mouse, rat EHF
      QuantiFast Probe-based Assays in human, mouse, rat EHF

    Additional mRNA sequence: 

    AF124438.1 AF124439.1 AF170583.1 AF203977.1 AF212848.1 AK026517.1 AK309318.1 AK310867.1 
    AY882601.1 BC038995.2 

    15 DOTS entries:

    DT.100796525  DT.91926463  DT.75188116  DT.97796149  DT.312572  DT.100734104  DT.120748644  DT.40252686 
    DT.99952009  DT.100796524  DT.120748676  DT.120748678  DT.86848298  DT.95070040  DT.75157494 

    Selected AceView cDNA sequences (see all 207):

    CD722845 CD723595 AI609633 CB130708 CB122697 AI201463 AW150115 AW074041 
    AI400359 CB113049 BU684240 AI972977 AI284098 CD723583 AA577041 AL708639 
    CB240726 BG742099 CK429387 AI142902 AA593133 AI903513 BU676246 CK430343 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for EHF (see all 16)    About this scheme

    ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10a · 10b · 10c ^ 11a · 11b · 11c ^ 12 ^ 13a · 13b ^ 14a · 14b ^ 15a · 15b ^
    SP1:                          -     -     -     -     -     -     -     -                                         -                                   -         
    SP2:                                -     -     -     -     -     -     -                                         -                                   -         
    SP3:                                                                                                              -                       -     -     -         
    SP4:                                                                                                              -                                   -         
    SP5:                                                  -     -     -     -                                         -                                             

    ExUns: 16a · 16b ^ 17a · 17b · 17c · 17d
    SP1:                                    
    SP2:                                    
    SP3:                                    
    SP4:                                    
    SP5:                                    


    ECgene alternative splicing isoforms for EHF

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    EHF expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GGCCCATATG
    EHF Expression
    About this image


    EHF expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 3) fully expand
     
     Kidney (Urinary System)    fully expand to see all 4 entries
             Ureteric Bud Cells Ureteric Bud
             Renal Collecting Duct System
     
     Colon (Gastrointestinal Tract)
     
     Epidermis (Integumentary System)
    EHF Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    EHF Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.653859

    UniProtKB/Swiss-Prot: EHF_HUMAN, Q9NZC4
    Tissue specificity: Expressed exclusively in tissues with a high content of epithelial cells. Highly expressed in
    salivary gland, mammary gland, prostate, and lung. Weakly expressed in kidney and colon. Not detected in heart,
    brain, placenta, liver, skeletal muscle, spleen, thymus, testis, ovary, small intestine or peripheral blood
    leukocytes

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    QuantiFast Probe-based Assays in human, mouse, rat EHF
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for EHF

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for EHF gene from Selected species (see all 15)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Ehf1 , 5 ets homologous factor1, 5 89(n)1
    93.67(a)1
      2 (54.43 cM)5
    136611  NM_007914.31  NP_031940.11 
     1032634335 
    chicken
    (Gallus gallus)
    Aves EHF1 ets homologous factor 79.53(n)
    86.24(a)
      425791  NM_001277584.1  NP_001264513.1 
    lizard
    (Anolis carolinensis)
    Reptilia EHF6
    ets homologous factor
    76(a)
    1 ↔ 1
    GL343283.1(1652781-1707738)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia ehf1 ets homologous factor 72.26(n)
    72.26(a)
      100493880  XM_002937289.2  XP_002937335.2 
    zebrafish
    (Danio rerio)
    Actinopterygii ehf1 ets homologous factor 62.53(n)
    60.64(a)
      568223  NM_001039822.1  NP_001034911.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta aop6
    anterior open
    9(a)
    1 → many
    2L(2156484-2178749)
    worm
    (Caenorhabditis elegans)
    Secernentea tag-976
    Protein TAG-97, isoform a
    15(a)
    1 → many
    X(15369998-15377685) WBGene00006462


    ENSEMBL Gene Tree for EHF (if available)
    TreeFam Gene Tree for EHF (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for EHF gene
    ELK42  ELF32  ELF42  ELF12  ELF52  ETV72  ELK12  ETV62  
    ELF22  SPDEF2  ELK32  
    2 SIMAP similar genes for EHF using alignment to 5 protein entries:     EHF_HUMAN (see all proteins):
    ELF5    ELF3

    Find genes that share paralogs with EHF           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for EHF (see all 1010)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 11 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs361246621,2
    C--34344056(+) TGGAGT/-CCTTT 2 -- int12Minor allele frequency- -:0.25NA CSA 4
    rs1856616461,2
    --34356757(+) TTTTTC/TCCTTT 3 -- int10--------
    rs1422788731,2
    C--34371551(+) GTGAA-/AGAAATT 3 -- int10--------
    rs340885051,2
    C--34371552(+) TGAAA-/G/GA  
            
    AAATT
    3 -- int11NA 2
    rs749030441,2
    --34371552(+) TGAAAA/GAAATT 3 -- int10--------
    rs49874131,2
    C--34371553(-) AATTT-/T/TC  
            
    CTTTC
    3 -- int10--------
    rs1430856341,2
    --34569286(+) ACAGGA/GCCTAT 2 -- us2k10--------
    rs1470731911,2
    C--34569423(+) AGGCAA/GTGGTG 2 -- us2k10--------
    rs1382710741,2
    --34569481(+) TAATGC/TTTCCC 2 -- us2k10--------
    rs1858783531,2
    --34569504(+) TGCCCC/TGCCAC 2 -- us2k10--------

    HapMap Linkage Disequilibrium report for EHF (34642588 - 34684835 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 3 variations for EHF:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv832117CNV Loss17160897
    dgv63n21CNV Gain19592680
    nsv832116CNV Gain17160897

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing EHF
    DNA2.0 Custom Variant and Variant Library Synthesis for EHF

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 605439    OMIM disorders: --

    3 diseases for EHF:    
    About MalaCards
    vertebrobasilar insufficiency    allergic urticaria    ebola hemorrhagic fever

    4 diseases from the University of Copenhagen DISEASES database for EHF:
    Vertebrobasilar insufficiency     Ebola hemorrhagic fever     Leprosy     Allergic urticaria

    Find genes that share disorders with EHF           About GenesLikeMe

    3 Novoseek inferred disease relationships for EHF gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    carcinoma 5.87 2 11259407 (1)
    tumors 0 2 18475289 (1), 12874078 (1)
    cancer 0 1 17172423 (1)

    Genetic Association Database (GAD): EHF
    Human Genome Epidemiology (HuGE) Navigator: EHF (3 documents)

    Export disorders for EHF gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for EHF gene, integrated from 10 sources (see all 47):
    (articles sorted by number of sources associating them with EHF)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Human chromosomal localization, tissue/tumor expression, and regulatory function of the ets family gene EHF. (PubMed id 10527851)1, 2, 3, 9 Kleinbaum L.A....Burton F.H. (Biochem. Biophys. Res. Commun. 1999)
    2. ESE-3, a novel member of an epithelium-specific ets transcription factor subfamily, demonstrates different target gene specificity from ESE-1. (PubMed id 10644770)1, 2, 9 Kas K.... Libermann T.A. (J. Biol. Chem. 2000)
    3. The epithelium-specific ETS protein EHF/ESE-3 is a context-dependent transcriptional repressor downstream of MAPK signaling cascades. (PubMed id 11259407)1, 2, 9 Tugores A.... McCormick M.K. (J. Biol. Chem. 2001)
    4. Genome-wide pharmacogenomic study of neurocognition as an indicator of antipsychotic treatment response in schizophrenia. (PubMed id 21107309)1, 4 McClay J.L....van den Oord E.J. (Neuropsychopharmacology 2011)
    5. Evaluating new candidate SNPs as low penetrance risk factors in sporadic breast cancer: a two-stage Spanish case-control study. (PubMed id 18950845)1, 4 Vega A....Carracedo A. (Gynecol. Oncol. 2009)
    6. Genetic correlates of brain aging on MRI and cognitive test measures: a genome-wide association and linkage analysis in the Framingham Study. (PubMed id 17903297)1, 4 Seshadri S....Wolf P.A. (BMC Med. Genet. 2007)
    7. ESE-3 transcription factor is involved in the expression of death receptor (DR)-5 through putative Ets sites. (PubMed id 17027647)1, 2 Lim J.H.... Kwon T.K. (Biochem. Biophys. Res. Commun. 2006)
    8. Human chromosome 11 DNA sequence and analysis including novel gene identification. (PubMed id 16554811)1, 2 Taylor T.D....Sakaki Y. (Nature 2006)
    9. Epithelial-specific transcription factor ESE-3 is involved in the development of monocyte-derived DCs. (PubMed id 16380452)1, 2 Appel S....Brossart P. (Blood 2006)
    10. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 26298 HGNC: 3246 AceView: EHF Ensembl:ENSG00000135373 euGenes: HUgn26298
    ECgene: EHF H-InvDB: EHF

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for EHF Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for EHF Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for EHF gene:
    Search GeneIP for patents involving EHF

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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