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EHD4 Gene

protein-coding   GIFtS: 56
GCID: GC15M042190

EH-Domain Containing 4


(Previous symbol: PAST4)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
EH-Domain Containing 41 2     EH Domain-Containing Protein 42
PAST41 2 3     Hepatocellular Carcinoma-Associated Protein HCA112
Hepatocellular Carcinoma-Associated Protein 10/112 3     Ortholog Of Rat Pincher2
PAST Homolog 42 3     HCA103
EH Domain Containing 42     HCA113

External Ids:    HGNC: 32451   Entrez Gene: 308442   Ensembl: ENSG000001039667   OMIM: 6058925   UniProtKB: Q9H2233   

Export aliases for EHD4 gene to outside databases

Previous GC identifers: GC15M037559 GC15M035087 GC15M039770 GC15M039907 GC15M039978 GC15M019040


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for EHD4 Gene:
EHD4 (EH-domain containing 4) is a protein-coding gene. Diseases associated with EHD4 include poland syndrome, and hepatocellular carcinoma. GO annotations related to this gene include nucleic acid binding and calcium ion binding. An important paralog of this gene is REPS1.

UniProtKB/Swiss-Prot: EHD4_HUMAN, Q9H223
Function: Plays a role in early endosomal transport

Gene Wiki entry for EHD4 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000015.10  NC_018926.2  NT_010194.18  
Regulatory elements:
   Regulatory transcription factor binding sites in the EHD4 gene promoter:
         SRF   ATF-2   SRF (504 AA)   Lmo2   Olf-1   CUTL1   POU6F1 (c2)   STAT5A   LyF-1   ATF   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): EHD4 promoter sequence
   Search Chromatin IP Primers for EHD4

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat EHD4


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 15q11.1   Ensembl cytogenetic band:  15q15.1   HGNC cytogenetic band: 15q11.1

EHD4 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
EHD4 gene location

GeneLoc information about chromosome 15         GeneLoc Exon Structure

GeneLoc location for GC15M042190:  view genomic region     (about GC identifiers)

Start:
42,190,950 bp from pter      End:
42,264,776 bp from pter
Size:
73,827 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: EHD4_HUMAN, Q9H223 (See protein sequence)
Recommended Name: EH domain-containing protein 4  
Size: 541 amino acids; 61175 Da
Subunit: Homooligomer, and heterooligomer with EHD1, EHD2 and EHD3
Secondary accessions: Q9HAR1 Q9NZN2

Explore the universe of human proteins at neXtProt for EHD4: NX_Q9H223

Explore proteomics data for EHD4 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys35
  • Modification sites at PhosphoSitePlus

  • See EHD4 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_644670.1  
    ENSEMBL proteins: 
     ENSP00000220325  

    EHD4 Human Recombinant Protein Products:

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    EHD4 Assay Products:

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    Cloud-Clone Corp. ELISAs for EHD4
    Cloud-Clone Corp. CLIAs for EHD4


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    EFHAND: EF-hand domain containing

    Selected InterPro protein domains (see all 6):
     IPR018247 EF_Hand_1_Ca_BS
     IPR001401 Dynamin_GTPase
     IPR011992 EF-hand-dom_pair
     IPR002048 EF_hand_dom
     IPR027417 P-loop_NTPase

    Graphical View of Domain Structure for InterPro Entry Q9H223

    ProtoNet protein and cluster: Q9H223

    1 Blocks protein domain: IPB000261 EPS15 homology (EH)

    UniProtKB/Swiss-Prot: EHD4_HUMAN, Q9H223
    Domain: The EH domain interacts with Asn-Pro-Phe (NPF) motifs of target proteins (By similarity)
    Similarity: Contains 1 EF-hand domain
    Similarity: Contains 1 EH domain


    EHD4 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: EHD4_HUMAN, Q9H223
    Function: Plays a role in early endosomal transport

         Gene Ontology (GO): Selected molecular function terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003676nucleic acid binding TAS10673336
    GO:0003924GTPase activity IEA--
    GO:0005509calcium ion binding IEA--
    GO:0005515protein binding IPI17233914
    GO:0005524ATP binding IEA--
         
    EHD4 for ontologies           About GeneDecksing


    Phenotypes:
         10 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Ehd4):
     cardiovascular system  cellular  endocrine/exocrine gland  growth/size/body  hearing/vestibular/ear 
     homeostasis/metabolism  mortality/aging  no phenotypic analysis  renal/urinary system  reproductive system 

    EHD4 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Ehd4tm1.1Haba for EHD4

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for EHD4
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for EHD4

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for EHD4
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for EHD4

    miRNA
    Products:
        
    miRTarBase miRNAs that target EHD4:
    hsa-mir-10a-5p (MIRT047751), hsa-let-7b-5p (MIRT032472)

    Block miRNA regulation of human, mouse, rat EHD4 using miScript Target Protectors
    8 qRT-PCR Assays for microRNAs that regulate EHD4:
    hsa-miR-34c-5p hsa-miR-1283 hsa-miR-449b hsa-miR-449a hsa-miR-34a hsa-miR-199a-5p hsa-miR-9 hsa-miR-199b-5p
    SwitchGear 3'UTR luciferase reporter plasmidEHD4 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for EHD4
    Predesigned siRNA for gene silencing in human, mouse, rat EHD4

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for EHD4

    Clone
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    OriGene clones in human, mouse for EHD4 (see all 7)
    OriGene ORF clones in mouse, rat for EHD4
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: EHD4 (NM_139265)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for EHD4
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat EHD4

    Cell Line
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    Browse ESI BIO Cell Lines and PureStem Progenitors for EHD4 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for EHD4


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    EHD4_HUMAN, Q9H223: Cell membrane (By similarity). Early endosome membrane; Peripheral membrane protein.
    Recycling endosome membrane; Peripheral membrane protein
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    endosome5
    endoplasmic reticulum4
    nucleus4
    cytosol3
    plasma membrane2
    extracellular1

    Gene Ontology (GO): Selected cellular component terms (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus TAS10673336
    GO:0005783endoplasmic reticulum IDA--
    GO:0005886plasma membrane IEA--
    GO:0031901early endosome membrane IEA--
    GO:0048471perinuclear region of cytoplasm IEA--

    EHD4 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for EHD4 About    
    See pathways by source

    SuperPathContained pathways About
    1Trk receptor signaling mediated by the MAPK pathway
    Trk receptor signaling mediated by the MAPK pathway
    2Neurotrophic factor-mediated Trk receptor signaling
    Neurotrophic factor-mediated Trk receptor signaling
    3Endocytosis
    Endocytosis

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    2 BioSystems Pathways for EHD4
        Neurotrophic factor-mediated Trk receptor signaling
    Trk receptor signaling mediated by the MAPK pathway


    1 Kegg Pathway  (Kegg details for EHD4):
        Endocytosis


    EHD4 for pathways           About GeneDecksing

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for EHD4
    Interactions:

        Search GeneGlobe Interaction Network for EHD4

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for EHD4 (Q9H2232, 3 ENSP000002203254) via UniProtKB, MINT, STRING, and/or I2D (see all 804)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CDC5LQ994592, ENSP000003605324MINT-7945693 MINT-7947479 STRING: ENSP00000360532
    CCT7Q998322, ENSP000002580914MINT-7945693 MINT-7947479 STRING: ENSP00000258091
    PSMC1P621912, ENSP000002613034MINT-7945693 MINT-7947479 STRING: ENSP00000261303
    RPLP0P053882, ENSP000003390274MINT-7945693 MINT-7947479 STRING: ENSP00000339027
    SNW1Q135732, ENSP000002615314MINT-7945693 MINT-7947479 STRING: ENSP00000261531
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006907pinocytosis IEA--
    GO:0030100regulation of endocytosis IEA--
    GO:0032456endocytic recycling IGI17233914
    GO:0050731positive regulation of peptidyl-tyrosine phosphorylation IEA--
    GO:0051260protein homooligomerization IPI17233914

    EHD4 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for EHD4



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for EHD4 gene: 
    NM_139265.3  

    Unigene Cluster for EHD4:

    EH-domain containing 4
    Hs.143703  [show with all ESTs]
    Unigene Representative Sequence: BC006287
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000220325(uc001zot.3) ENST00000569223(uc001zou.2)
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat EHD4 using miScript Target Protectors
    8 qRT-PCR Assays for microRNAs that regulate EHD4:
    hsa-miR-34c-5p hsa-miR-1283 hsa-miR-449b hsa-miR-449a hsa-miR-34a hsa-miR-199a-5p hsa-miR-9 hsa-miR-199b-5p
    SwitchGear 3'UTR luciferase reporter plasmidEHD4 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for EHD4
    Predesigned siRNA for gene silencing in human, mouse, rat EHD4
    Clone
    Products:
         
    OriGene clones in human, mouse for EHD4 (see all 7)
    OriGene ORF clones in mouse, rat for EHD4
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: EHD4 (NM_139265)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for EHD4
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat EHD4
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for EHD4
    OriGene qSTAR qPCR primer pairs in human, mouse for EHD4
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat EHD4
      QuantiTect SYBR Green Assays in human, mouse, rat EHD4
      QuantiFast Probe-based Assays in human, mouse, rat EHD4

    Additional mRNA sequence: 

    AF086163.1 AF181265.1 AF307137.1 AF323924.1 AF454953.1 AK024902.1 AK074621.1 AK292634.1 
    BC006287.2 BC051823.1 BC077716.1 

    10 DOTS entries:

    DT.422470  DT.86859211  DT.100780976  DT.100029092  DT.92376237  DT.100780975  DT.100653537  DT.121078170 
    DT.95171768  DT.95211254 

    Selected AceView cDNA sequences (see all 172):

    BU179619 BF793649 AI832117 BI819581 BM905006 BG291272 AA412632 C04838 
    BI759219 CD364594 BQ435152 AL137436 CO406075 AW069505 BU071012 BU196308 
    BM272295 BF206083 BM691572 CF139259 BI818113 BM477935 BG055095 AW337318 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    EHD4 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TCAAATCACA
    EHD4 Expression
    About this image


    EHD4 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 2) fully expand
     
     Trophoblast (Extraembryonic Tissues)
             Mural Trophectoderm Cells Mural Trophectoderm
     
     Blood (Hematopoietic System)
             Monocytes Peripheral Blood
    EHD4 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    EHD4 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.143703

    UniProtKB/Swiss-Prot: EHD4_HUMAN, Q9H223
    Tissue specificity: Highly expressed in pancreas and heart

        Custom PCR Arrays for EHD4
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    QuantiFast Probe-based Assays in human, mouse, rat EHD4
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for EHD4

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of eukaryotes.

    Orthologs for EHD4 gene from Selected species (see all 17)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Ehd41 , 5 EH-domain containing 41, 5 90.76(n)1
    97.04(a)1
      2 (60.16 cM)5
    988781  NM_133838.41  NP_598599.21 
     1200891755 
    chicken
    (Gallus gallus)
    Aves LOC1008598601 EH domain-containing protein 4-like 77.07(n)
    89.45(a)
      100859860  XM_003641349.2  XP_003641397.2 
    lizard
    (Anolis carolinensis)
    Reptilia EHD46
    EH-domain containing 4
    87(a)
    1 ↔ 1
    1(40545999-40570775)
    African clawed frog
    (Xenopus laevis)
    Amphibia BC045029.12   -- 73.59(n)    BC045029.1 
    zebrafish
    (Danio rerio)
    Actinopterygii im:71471831 im:7147183 71.31(n)
    77.32(a)
      569546  XM_692941.4  XP_698033.4 
    Alicante grape
    (Vitis vinifera)
    eudicotyledons Vvi.15912 Vitis vinifera transcribed sequence with moderate similarity more 75.41(n)    CA808935.1 
    corn
    (Zea mays)
    Liliopsida Zm.37192 Zea mays CL37059_1 mRNA sequence 72.3(n)    AY110908.1 


    ENSEMBL Gene Tree for EHD4 (if available)
    TreeFam Gene Tree for EHD4 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for EHD4 gene
    REPS12  EPS15L12  EHD32  REPS22  EHD22  EHD12  ITSN12  EPS152  
    ITSN22  SRL2  
    4 SIMAP similar genes for EHD4 using alignment to 1 protein entry:     EHD4_HUMAN:
    EHD1    EHD3    EHD2    SRL

    EHD4 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for EHD4 (see all 1597)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 15 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1871588181,2
    --42191197(+) TAAATA/GCTTCT 1 -- int10--------
    rs346076491,2
    C--42191264(+) AAAAAA/-TTATG 1 -- int12Minor allele frequency- -:0.25NA CSA 4
    rs116361781,2
    C,F,H--42191348(+) CATACC/TATGTG 1 -- int16Minor allele frequency- T:0.09NA WA 248
    rs1457038151,2
    --42191453(+) GAAAAC/GTCACC 1 -- int10--------
    rs1489409201,2
    --42191506(+) CCTGAC/TGCAGG 1 -- int10--------
    rs110703531,2
    C,F,A,H--42191519(+) TCTGAG/ACAGCA 1 -- int111Minor allele frequency- A:0.28NA WA CSA EA 374
    rs1904396981,2
    --42191604(+) TGCCTC/TGTGAT 1 -- int10--------
    rs1458783921,2
    C--42191654(+) GGTTTC/TATATG 1 -- ut310--------
    rs1809459371,2
    --42191716(+) AAAAAA/CCACAA 1 -- ut310--------
    rs10481751,2
    C,F,O,A,H--42191909(+) GACCTC/GGGGAT 1 -- ut31 ese316Minor allele frequency- G:0.38MN NS EA NA WA CSA 974

    HapMap Linkage Disequilibrium report for EHD4 (42190950 - 42264776 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 7 variations for EHD4:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv273033CNV Insertion20981092
    dgv2366n71CNV Loss21882294
    dgv2364n71CNV Loss21882294
    nsv519577CNV Loss19592680
    nsv904116CNV Loss21882294
    nsv904129CNV Loss21882294
    nsv9244CNV Gain18304495

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing EHD4
    DNA2.0 Custom Variant and Variant Library Synthesis for EHD4

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 605892    OMIM disorders: --

    5 diseases for EHD4:    
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    poland syndrome    hepatocellular carcinoma    endometritis    hiv-1
    endotheliitis


    EHD4 for disorders           About GeneDecksing

    Genetic Association Database (GAD): EHD4

    Export disorders for EHD4 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for EHD4 gene, integrated from 10 sources (see all 30):
    (articles sorted by number of sources associating them with EHD4)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. EHD2, EHD3, and EHD4 encode novel members of a highly conserved family of EH domain-containing proteins. (PubMed id 10673336)1, 2, 3 Pohl U.... Louis D.N. (Genomics 2000)
    2. A role for EHD4 in the regulation of early endosomal transport. (PubMed id 18331452)1, 2 Sharma M.... Caplan S. (Traffic 2008)
    3. Shared as well as distinct roles of EHD proteins revealed by biochemical and functional comparisons in mammalian cells and C. elegans. (PubMed id 17233914)1, 2 George M.... Band H. (BMC Cell Biol. 2007)
    4. Immunoaffinity profiling of tyrosine phosphorylation in cancer cells. (PubMed id 15592455)1, 2 Rush J.... Comb M.J. (Nat. Biotechnol. 2005)
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    6. Large scale identification of human hepatocellular carcinoma- associated antigens by autoantibodies. (PubMed id 12097419)1, 2 Wang Y....Chen W.-F. (J. Immunol. 2002)
    7. Characterization of EHD4, an EH domain-containing protein expressed in the extracellular matrix. (PubMed id 11533061)1, 3 Kuo H.J....Glanville R.W. (J. Biol. Chem. 2001)
    8. Comparative proteomic analysis of HIV-1 particles reveals a role for Ezrin and EHD4 in the Nef-dependent increase of virus infectivity. (PubMed id 23325686)1 BrAcgnard C....Basmaciogullari S. (J. Virol. 2013)
    9. Differential roles of C-terminal Eps15 homology domain proteins as vesiculators and tubulators of recycling endosomes. (PubMed id 24019528)1 Cai B....Caplan S. (J. Biol. Chem. 2013)
    10. A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (Cell 2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 30844 HGNC: 3245 AceView: EHD4 Ensembl:ENSG00000103966 euGenes: HUgn30844
    ECgene: EHD4 Kegg: 30844 H-InvDB: EHD4

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for EHD4 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for EHD4 gene:
    Search GeneIP for patents involving EHD4

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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