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EHD2 Gene

protein-coding   GIFtS: 57
GCID: GC19P048216

EH-Domain Containing 2


(Previous symbol: PAST2)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
EH-Domain Containing 21 2
PAST21 2 3
PAST Homolog 22 3
EH Domain Containing 22
EH Domain-Containing Protein 22

External Ids:    HGNC: 32431   Entrez Gene: 308462   Ensembl: ENSG000000244227   OMIM: 6058905   UniProtKB: Q9NZN43   

Export aliases for EHD2 gene to outside databases

Previous GC identifers: GC19P048863 GC19P048607 GC19P052892 GC19P052908 GC19P044643


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for EHD2 Gene:
This gene encodes a member of the EH domain-containing protein family. These proteins are characterized by a
C-terminal EF-hand domain, a nucleotide-binding consensus site at the N terminus and a bipartite nuclear
localization signal. The encoded protein interacts with the actin cytoskeleton through an N-terminal domain and
also binds to an EH domain-binding protein through the C-terminal EH domain. This interaction appears to connect
clathrin-dependent endocytosis to actin, suggesting that this gene product participates in the endocytic pathway.
(provided by RefSeq, Jul 2008)

GeneCards Summary for EHD2 Gene:
EHD2 (EH-domain containing 2) is a protein-coding gene. Diseases associated with EHD2 include pathological gambling, and hemorrhagic disease. GO annotations related to this gene include nucleic acid binding and calcium ion binding. An important paralog of this gene is REPS1.

UniProtKB/Swiss-Prot: EHD2_HUMAN, Q9NZN4
Function: Plays a role in membrane reorganization in response to nucleotide hydrolysis. Binds to liposomes and
deforms them into tubules. Plays a role in membrane trafficking between the plasma membrane and endosomes.
Important for the internalization of GLUT4. Required for normal fusion of myoblasts to skeletal muscle myotubes.
Required for translocation of FER1L5 to the plasma membrane. Binds ATP; does not bind GTP (By similarity)

Gene Wiki entry for EHD2 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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Regulatory elements:
   Regulatory transcription factor binding sites in the EHD2 gene promoter:
         Spz1   MyoD   HNF-4alpha2   LCR-F1   HNF-4alpha1   CREB   STAT3   ATF6   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidEHD2 promoter sequence
   Search Chromatin IP Primers for EHD2

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat EHD2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19q13.3   Ensembl cytogenetic band:  19q13.33   HGNC cytogenetic band: 19q13.3

EHD2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
EHD2 gene location

GeneLoc information about chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19P048216:  view genomic region     (about GC identifiers)

Start:
48,216,600 bp from pter      End:
48,246,391 bp from pter
Size:
29,792 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: EHD2_HUMAN, Q9NZN4 (See protein sequence)
Recommended Name: EH domain-containing protein 2  
Size: 543 amino acids; 61161 Da
Subunit: Interacts with Asn-Pro-Phe (NPF) motifs in target proteins. Interacts with EHBP1. Interacts with FER1L5
(via second C2 domain) (By similarity). Homodimer and homooligomer. Interacts with EHD1 and MYOF. May also
interact with EHD3 and EHD4
Secondary accessions: B2RDH9 Q96CB6

Explore the universe of human proteins at neXtProt for EHD2: NX_Q9NZN4

Explore proteomics data for EHD2 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See EHD2 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_055416.2  
    ENSEMBL proteins: 
     ENSP00000263277   ENSP00000439036   ENSP00000471766  
    Reactome Protein details: Q9NZN4

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    EFHAND: EF-hand domain containing

    Selected InterPro protein domains (see all 6):
     IPR018247 EF_Hand_1_Ca_BS
     IPR001401 Dynamin_GTPase
     IPR011992 EF-hand-dom_pair
     IPR002048 EF_hand_dom
     IPR027417 P-loop_NTPase

    Graphical View of Domain Structure for InterPro Entry Q9NZN4

    ProtoNet protein and cluster: Q9NZN4

    1 Blocks protein domain: IPB000261 EPS15 homology (EH)

    UniProtKB/Swiss-Prot: EHD2_HUMAN, Q9NZN4
    Domain: The EH domain interacts with Asn-Pro-Phe (NPF) motifs of target proteins (By similarity)
    Similarity: Contains 1 EF-hand domain
    Similarity: Contains 1 EH domain


    EHD2 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: EHD2_HUMAN, Q9NZN4
    Function: Plays a role in membrane reorganization in response to nucleotide hydrolysis. Binds to liposomes and
    deforms them into tubules. Plays a role in membrane trafficking between the plasma membrane and endosomes.
    Important for the internalization of GLUT4. Required for normal fusion of myoblasts to skeletal muscle myotubes.
    Required for translocation of FER1L5 to the plasma membrane. Binds ATP; does not bind GTP (By similarity)
    Enzyme regulation: The very low intrinsic ATPase activity is increased upon interaction with liposomes (By
    similarity)

         Gene Ontology (GO): Selected molecular function terms (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003676nucleic acid binding TAS10673336
    GO:0003924GTPase activity IEA--
    GO:0005509calcium ion binding IEA--
    GO:0005515protein binding IPI17233914
    GO:0005524ATP binding IEA--
         
    EHD2 for ontologies           About GeneDecksing


    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for EHD2
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    miRNA
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    miRTarBase miRNAs that target EHD2:
    hsa-mir-197-3p (MIRT004199), hsa-mir-124-3p (MIRT022318)

    Block miRNA regulation of human, mouse, rat EHD2 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate EHD2 (see all 14):
    hsa-miR-600 hsa-miR-29a hsa-miR-29c hsa-miR-3907 hsa-miR-3137 hsa-miR-3150a-3p hsa-miR-214 hsa-miR-544b
    SwitchGear 3'UTR luciferase reporter plasmidEHD2 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat EHD2

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    GenScript: all cDNA clones in your preferred vector: EHD2 (NM_014601)
    Sino Biological Human cDNA Clone for EHD2
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat EHD2

    Cell Line
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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for EHD2


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    EHD2_HUMAN, Q9NZN4: Cell membrane; Peripheral membrane protein; Cytoplasmic side. Endosome membrane; Peripheral
    membrane protein (By similarity). Note=Colocalizes with GLUT4 in intracellular tubulovesicular structures that
    are associated with cortical F-actin. Colocalizes with FER1L5 at plasma membrane in myoblasts and myotubes (By
    similarity)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    endosome5
    plasma membrane5
    nucleus4
    cytosol3
    cytoskeleton1
    mitochondrion1

    Gene Ontology (GO): Selected cellular component terms (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus TAS10673336
    GO:0005886plasma membrane ISS--
    GO:0010008endosome membrane TAS--
    GO:0016020membrane ----
    GO:0048471perinuclear region of cytoplasm IEA--

    EHD2 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for EHD2 About    
    See pathways by source

    SuperPathContained pathways About
    1Hemostasis
    Hemostasis0.43
    2Insulin Signaling
    Insulin Signaling
    3Factors involved in megakaryocyte development and platelet production
    Factors involved in megakaryocyte development and platelet production
    4Endocytosis
    Endocytosis

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 BioSystems Pathway for EHD2
        Insulin Signaling


    1 Reactome Pathway for EHD2
        Factors involved in megakaryocyte development and platelet production


    1 Kegg Pathway  (Kegg details for EHD2):
        Endocytosis


    EHD2 for pathways           About GeneDecksing

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for EHD2
    Interactions:

        GeneGlobe Interaction Network for EHD2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for EHD2 (Q9NZN43 ENSP000002632774) via UniProtKB, MINT, STRING, and/or I2D (see all 41)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    SLC2A4P146723, ENSP000003209354I2D: score=3 STRING: ENSP00000320935
    EHBP1Q8NDI13, ENSP000002639914I2D: score=2 STRING: ENSP00000263991
    AP1M2Q9Y6Q53, ENSP000002502444I2D: score=1 STRING: ENSP00000250244
    AP2M1Q96CW13, ENSP000002928074I2D: score=2 STRING: ENSP00000292807
    MYOFQ9NZM13, ENSP000003522084I2D: score=1 STRING: ENSP00000352208
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006897endocytosis IEA--
    GO:0007596blood coagulation TAS--
    GO:0030866cortical actin cytoskeleton organization IEA--
    GO:0032456endocytic recycling IGI17233914
    GO:0072659protein localization to plasma membrane ISS--

    EHD2 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for EHD2

    1 HMDB Compound for EHD2    About this table
    CompoundSynonyms CAS #PubMed Ids
    Guanosine triphosphate5'-GTP (see all 10)86-01-1--



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for EHD2 gene: 
    NM_014601.3  

    5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000263277(uc002phj.4 uc010xyu.2) ENST00000538399 ENST00000602215
    ENST00000596225 ENST00000540884
    miRNA
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    Block miRNA regulation of human, mouse, rat EHD2 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate EHD2 (see all 14):
    hsa-miR-600 hsa-miR-29a hsa-miR-29c hsa-miR-3907 hsa-miR-3137 hsa-miR-3150a-3p hsa-miR-214 hsa-miR-544b
    SwitchGear 3'UTR luciferase reporter plasmidEHD2 3' UTR sequence
    Inhib. RNA
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      QuantiTect SYBR Green Assays in human, mouse, rat EHD2
      QuantiFast Probe-based Assays in human, mouse, rat EHD2

    Selected AceView cDNA sequences (see all 205):

    BQ219550 AA708621 AI755034 CN484049 BE313316 BG913167 BP372276 BP343219 
    CB153909 BG831594 AA699711 BP352521 CR607936 AI148368 BM697990 T35648 
    AW015358 CD516703 BE877088 BE908282 AW732371 CR609202 AA404366 BU147498 

    GeneLoc Exon Structure

    4 Alternative Splicing Database (ASD) splice patterns (SP) for EHD2    About this scheme

    ExUns: 1 ^ 2a · 2b ^ 3a · 3b ^ 4a · 4b ^ 5a · 5b ^ 6 ^ 7 ^ 8
    SP1:                                                                        
    SP2:              -     -     -     -                                       
    SP3:                                                                        
    SP4:                                                                        


    ECgene alternative splicing isoforms for EHD2

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    EHD2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GCTGGGAGGG
    EHD2 Expression
    About this image


    EHD2 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 5) fully expand
     
     Lung (Respiratory System)    fully expand to see all 2 entries
             Basal Cells Respiratory Bronchioles
     
     Endothelium (Cardiovascular System)
             Extraembryonic Angioblasts Extraembryonic Capillary Plexus
     
     Extraembryonic Mesoderm (Extraembryonic Tissues)
             Extraembryonic Angioblasts Extraembryonic Capillary Plexus
     
     Adipose (Muscoskeletal System)
     
     Bone (Muscoskeletal System)
    EHD2 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    EHD2 Protein Expression

    UniProtKB/Swiss-Prot: EHD2_HUMAN, Q9NZN4
    Tissue specificity: Highly expressed in heart and moderately expressed in placenta, lung, and skeletal muscle

        Custom PCR Arrays for EHD2
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    QuantiFast Probe-based Assays in human, mouse, rat EHD2
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for EHD2

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for EHD2 gene from Selected species (see all 12)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Ehd21 , 5 EH-domain containing 21, 5 87.48(n)1
    96.69(a)1
      7 (8.65 cM)5
    2593001  NM_153068.31  NP_694708.21 
     159469775 
    lizard
    (Anolis carolinensis)
    Reptilia --
    --
    Uncharacterized protein
    84(a)
    76(a)
    many → 1
    many → 1
    GL344061.1(96339-102077)
    GL344801.1(5201-15929)
    African clawed frog
    (Xenopus laevis)
    Amphibia MGC642662 hypothetical protein MGC64266 74.59(n)    BC054951.1 
    zebrafish
    (Danio rerio)
    Actinopterygii BC063963.12   -- 78.49(n)   337401  BC063963.1 


    ENSEMBL Gene Tree for EHD2 (if available)
    TreeFam Gene Tree for EHD2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for EHD2 gene
    REPS12  EPS15L12  EHD32  REPS22  EHD12  EHD42  ITSN12  EPS152  
    ITSN22  SRL2  
    4 SIMAP similar genes for EHD2 using alignment to 3 protein entries:     EHD2_HUMAN (see all proteins):
    EHD1    EHD3    EHD4    SRL

    EHD2 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for EHD2 (see all 835)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 19 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs602958741,2
    C--44645950(+) TTTTT-/T/TT  
            
    GAGAT
    1 -- int11NA 2
    rs723742861,2
    C--48214661(+) CGCCG-/TTAATC 1 -- us2k10--------
    rs1828306441,2
    C--48214738(+) GAGATC/TGTGCC 1 -- us2k10--------
    rs1465574651,2
    --48214739(+) AGATCA/GTGCCA 1 -- us2k10--------
    rs1139207141,2
    C,F--48214850(+) CTGGGG/AAGATT 1 -- us2k12Minor allele frequency- A:0.03CSA NA 122
    rs1412068871,2
    --48214887(+) GAGGCA/GGAGGT 1 -- us2k10--------
    rs1887949921,2
    --48214933(+) CTGGGC/TGATAG 1 -- us2k10--------
    rs621307031,2
    --48214971(+) AAAACA/CAAAAC 1 -- us2k11Minor allele frequency- C:0.00CSA 1
    rs563956111,2
    C--48214977(+) AAAACC/TCCAAA 1 -- us2k10--------
    rs1928583931,2
    --48215015(+) GGTTCA/GATGAG 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for EHD2 (48216600 - 48246391 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 9 variations for EHD2:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2718666CNV Deletion23290073
    nsv912211CNV Loss21882294
    nsv912206CNV Loss21882294
    nsv138164CNV Loss16902084
    dgv3964n71CNV Loss21882294
    nsv912205CNV Loss21882294
    nsv912203CNV Gain21882294
    nsv912210CNV Gain21882294
    nsv912204CNV Gain21882294

    Human Gene Mutation Database (HGMD): EHD2
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing EHD2
    DNA2.0 Custom Variant and Variant Library Synthesis for EHD2

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 605890    OMIM disorders: --

    6 diseases for EHD2:    
    About MalaCards
    pathological gambling    hemorrhagic disease    bronchiolitis    esophageal squamous cell carcinoma
    esophagitis    squamous cell carcinoma

    1 disease from the University of Copenhagen DISEASES database for EHD2:
    Pathological gambling

    EHD2 for disorders           About GeneDecksing


    Export disorders for EHD2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for EHD2 gene, integrated from 10 sources (see all 32):
    (articles sorted by number of sources associating them with EHD2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. EHD2, EHD3, and EHD4 encode novel members of a highly conserved family of EH domain-containing proteins. (PubMed id 10673336)1, 2, 3 Pohl U.... Louis D.N. (Genomics 2000)
    2. Shared as well as distinct roles of EHD proteins revealed by biochemical and functional comparisons in mammalian cells and C. elegans. (PubMed id 17233914)1, 2 George M.... Band H. (BMC Cell Biol. 2007)
    3. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)1, 2 Olsen J.V....Mann M. (Cell 2006)
    4. Vectorial proteomics reveal targeting, phosphorylation and specific fragmentation of polymerase I and transcript release factor (PTRF) at the surface of caveolae in human adipocytes. (PubMed id 15242332)1, 2 Aboulaich N.... Vener A.V. (Biochem. J. 2004)
    5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    6. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    7. Effects of EHD2 interference on migration of esophageal squamous cell carcinoma. (PubMed id 23354948)1 Li M....Wang H. (Med. Oncol. 2013)
    8. A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (Cell 2012)
    9. EHD2 shuttles to the nucleus and represses transcription. (PubMed id 22448906)1 Pekar O....Horowitz M. (Biochem. J. 2012)
    10. Oligomers of the ATPase EHD2 confine caveolae to the plasma membrane through association with actin. (PubMed id 22505029)1 Stoeber M....Helenius A. (EMBO J. 2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 30846 HGNC: 3243 AceView: EHD2 Ensembl:ENSG00000024422 euGenes: HUgn30846
    ECgene: EHD2 Kegg: 30846 H-InvDB: EHD2

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for EHD2 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for EHD2 gene:
    Search GeneIP for patents involving EHD2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014

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