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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

EGR4 Gene

protein-coding   GIFtS: 57
GCID: GC02M073518

Early Growth Response 4

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Early Growth Response 41 2     NGFI-C2
AT1332 3     PAT1332
EGR-42 3     Early Growth Response Protein 42
NGFIC2 5     

External Ids:    HGNC: 32411   Entrez Gene: 19612   Ensembl: ENSG000001356257   OMIM: 1289925   UniProtKB: Q052153   

Export aliases for EGR4 gene to outside databases

Previous GC identifers: GC02M073527 GC02M073728 GC02M073493 GC02M073494 GC02M073430 GC02M073253


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for EGR4 Gene: 
EGR4 (early growth response 4) is a protein-coding gene. Diseases associated with EGR4 include tooth disease, and charcot-marie-tooth disease, and among its related super-pathways are Calcium signaling in the CD4+ TCR pathway. GO annotations related to this gene include DNA binding and sequence-specific DNA binding transcription factor activity. An important paralog of this gene is EGR3.

UniProtKB/Swiss-Prot: EGR4_HUMAN, Q05215
Function: Transcriptional regulator. Recognizes and binds to the DNA sequence 5'-GCGGGGGCG-3' (GSG). Activates the
transcription of target genes whose products are required for mitogenesis and differentiation (By similarity)

Gene Wiki entry for EGR4 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000002.11  NC_018913.2  NT_022184.15  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the EGR4 gene promoter:
         STAT1   GATA-3   NRSF form 1   MyoD   NRSF form 2   STAT1alpha   CP2   ZIC2/Zic2   Pax-4a   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidEGR4 promoter sequence
   Search SABiosciences Chromatin IP Primers for EGR4

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat EGR4


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2p13   Ensembl cytogenetic band:  2p13.1   HGNC cytogenetic band: 2p13

EGR4 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
EGR4 gene location

GeneLoc information about chromosome 2         GeneLoc Exon Structure

GeneLoc location for GC02M073518:  view genomic region     (about GC identifiers)

Start:
73,518,057 bp from pter      End:
73,520,833 bp from pter
Size:
2,777 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: EGR4_HUMAN, Q05215 (See protein sequence)
Recommended Name: Early growth response protein 4  
Size: 589 amino acids; 61623 Da
Subcellular location: Nucleus (Probable)
Caution: It is uncertain whether Met-1 or Met-104 is the initiator. Some orthologous sequences can not be extended
Sequence caution: Sequence=AAX88903.1; Type=Erroneous initiation; Note=Translation N-terminally extended;
Sequence=BAG36840.1; Type=Erroneous initiation; Note=Translation N-terminally extended; Sequence=CAA42698.1;
Type=Frameshift; Positions=66; Sequence=CAA49214.1; Type=Frameshift; Positions=66;
Secondary accessions: B2RAE3 G3V1T5 Q2Z1P5

Explore the universe of human proteins at neXtProt for EGR4: NX_Q05215

Explore proteomics data for EGR4 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q05215

  • EGR4 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    EGR4 Protein Expression
    REFSEQ proteins: NP_001956.3  
    ENSEMBL proteins: 
     ENSP00000419687   ENSP00000445626  

    Human Recombinant Protein Products for EGR4: 
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    Novus Biologicals EGR4 Protein
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for EGR4 

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IBA--
    GO:0005737cytoplasm IBA--

    EGR4 for ontologies           About GeneDecksing



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    LSBio Antibodies in human, mouse, rat for EGR4 

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    Browse Kits and Assays available from EMD Millipore
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    Cloud-Clone Corp. ELISAs for EGR4 
    Cloud-Clone Corp. CLIAs for EGR4


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    ZNF: Zinc fingers, C2H2-type

    3 InterPro protein domains:
     IPR015880 Znf_C2H2-like
     IPR013087 Znf_C2H2/integrase_DNA-bd
     IPR007087 Znf_C2H2

    Graphical View of Domain Structure for InterPro Entry Q05215

    ProtoNet protein and cluster: Q05215

    1 Blocks protein domain: IPB007086 C2H2-type zinc finger signature

    UniProtKB/Swiss-Prot: EGR4_HUMAN, Q05215
    Similarity: Belongs to the EGR C2H2-type zinc-finger protein family
    Similarity: Contains 3 C2H2-type zinc fingers


    EGR4 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: EGR4_HUMAN, Q05215
    Function: Transcriptional regulator. Recognizes and binds to the DNA sequence 5'-GCGGGGGCG-3' (GSG). Activates the
    transcription of target genes whose products are required for mitogenesis and differentiation (By similarity)
    Induction: By PHA/PMA or by serum

         Genatlas biochemistry entry for EGR4:
    immediate early growth response,gene 4 (pAT133),nerve growth factor induced clone C

         Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003677DNA binding IEA--
    GO:0003700sequence-specific DNA binding transcription factor activity NAS1584812
    GO:0008270zinc ion binding ----
    GO:0046872metal ion binding IEA--
         
    EGR4 for ontologies           About GeneDecksing


    Phenotypes:
         4 MGI mutant phenotypes (inferred from 1 allele(MGI details for Egr4):
     cellular  endocrine/exocrine gland  homeostasis/metabolism  reproductive system 

    EGR4 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Egr4tm1Jmi for EGR4

       inGenious Targeting Laboratory - Custom generated mouse model solutions for EGR4 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for EGR4

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for EGR4 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for EGR4 

    miRNA
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    8/17 QIAGEN miScript miRNA Assays for microRNAs that regulate EGR4 (see all 17):
    hsa-miR-100* hsa-miR-4328 hsa-miR-520d-5p hsa-miR-330-5p hsa-miR-637 hsa-miR-326 hsa-miR-330-3p hsa-miR-374b*
    SwitchGear 3'UTR luciferase reporter plasmidEGR4 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for EGR4
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    Gene Editing
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    Clone
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    OriGene ORF clones in mouse, rat for EGR4
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                         Customized lentivirus expression plasmids for stable overexpression of EGR4 

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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for EGR4


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for EGR4 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Calcium signaling in the CD4+ TCR pathway
    Calcineurin-regulated NFAT-dependent transcription in lymphocytes0.38
    2Downstream signaling in naive CD8+ T cells
    Downstream signaling in naive CD8+ T cells


    2 BioSystems Pathways for EGR4
        Calcineurin-regulated NFAT-dependent transcription in lymphocytes
    Downstream signaling in naive CD8+ T cells


    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for EGR4

    STRING Interaction Network Preview (showing 3 interactants - click image to see more details)

    3 Interacting proteins for EGR4 (Q052153 ENSP000004196874) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    NFATC1O956443, ENSP000003278504I2D: score=1 STRING: ENSP00000327850
    NFATC2Q134693, ENSP000003793304I2D: score=1 STRING: ENSP00000379330
    NFATC3ENSP000003006594STRING: ENSP00000300659
    About this table

    Gene Ontology (GO): 5 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006351transcription, DNA-dependent IEA--
    GO:0008284positive regulation of cell proliferation TAS1658795
    GO:0043066negative regulation of apoptotic process IBA--
    GO:0071320cellular response to cAMP IBA--
    GO:0071371cellular response to gonadotropin stimulus IBA--

    EGR4 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for EGR4

    Search CenterWatch for drugs/clinical trials and news about EGR4

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for EGR4 gene: 
    NM_001965.3  

    Unigene Cluster for EGR4:

    Early growth response 4
    Hs.3052  [show with all ESTs]
    Unigene Representative Sequence: NM_001965
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000436467 ENST00000545030(uc010yrj.2 uc010yrk.1)
    miRNA
    Products:
         
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat EGR4
    8/17 QIAGEN miScript miRNA Assays for microRNAs that regulate EGR4 (see all 17):
    hsa-miR-100* hsa-miR-4328 hsa-miR-520d-5p hsa-miR-330-5p hsa-miR-637 hsa-miR-326 hsa-miR-330-3p hsa-miR-374b*
    SwitchGear 3'UTR luciferase reporter plasmidEGR4 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for EGR4
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat EGR4
    Clone
    Products:
         
    OriGene clones in human, mouse for EGR4 (see all 9)
    OriGene ORF clones in mouse, rat for EGR4
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: EGR4 (NM_001965)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for EGR4
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat EGR4
    Sirion Biotech Customized lentivirus for stable overexpression of EGR4 
                         Customized lentivirus expression plasmids for stable overexpression of EGR4 
    Primer
    Products:
        
    OriGene qSTAR qPCR primer pairs in human, mouse for EGR4
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat EGR4
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat EGR4
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat EGR4

    Additional mRNA sequence: 

    AK314154.1 BC136252.1 BC143379.1 X60104.1 

    2 DOTS entries:

    DT.104276  DT.95199431 

    8 AceView cDNA sequences:

    H42245 BC034462 X60104 NM_001965 BX395919 AI223359 BM563959 BI822363 

    GeneLoc Exon Structure

    2 Alternative Splicing Database (ASD) splice patterns (SP) for EGR4    About this scheme

    ExUns: 1a · 1b ^ 2a · 2b
    SP1:                        
    SP2:                        


    ECgene alternative splicing isoforms for EGR4

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    EGR4 expression in normal human tissues (normalized intensities)      EGR4 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TCGGGCATCT
    EGR4 Expression
    About this image


    EGR4 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/7 selected tissues (see all 7) fully expand
     
     Neural Tube (Nervous System)
             Prosencephalon
     
     Skeletal Muscle (Muscoskeletal System)
             Muscle Progenitor Cells Thoracic Ventrolateral Dermomyotome Lip
     
     Somite (Muscoskeletal System)
             Muscle Progenitor Cells Thoracic Ventrolateral Dermomyotome Lip
     
     Lung (Respiratory System)
     
     Epidermis (Integumentary System)

    See EGR4 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for EGR4

    SOURCE GeneReport for Unigene cluster: Hs.3052
        SABiosciences Expression via Pathway-Focused PCR Array including EGR4: 
              Synaptic Plasticity in human mouse rat

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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for EGR4

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for EGR4 gene from 5/10 species (see all 10)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Egr41 , 5 early growth response 41, 5 85.32(n)1
    86.79(a)1
      6 (37.48 cM)5
    136561  NM_020596.21  NP_065621.11 
     855111225 
    chicken
    (Gallus gallus)
    Aves EGR41 early growth response 4 62(n)
    56.48(a)
      422950  XM_420888.1  XP_420888.1 
    zebrafish
    (Danio rerio)
    Actinopterygii CF998734.12   -- 82.93(n)    CF998734.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta klu6
    klumpfuss
    10(a)
    possible ortholog
    3L(10974271-11001933)
    worm
    (Caenorhabditis elegans)
    Secernentea C27C12.23 Zinc finger, C2H2 type (3 domains) 75(a)
    (best of 2)
      X(14881084-14882208)   --


    ENSEMBL Gene Tree for EGR4 (if available)
    TreeFam Gene Tree for EGR4 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for EGR4 gene
    EGR32  EGR12  WT12  EGR22  
    18/27 SIMAP similar genes for EGR4 using alignment to 2 protein entries:     EGR4_HUMAN (see all proteins) (see all similar genes):
    WT1    DKFZp434J0650    DKFZp686N0199    ZNF468    ZFS-5    A-328A3.4
    smap-7    ZNF697    ZNF78L1    DKFZp686M04222    DKFZp686O1631    ZNF740
    ZNF    ZNF138    kr-znf3    ZFS-6    ZNF72    DKFZp547H249

    EGR4 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/115 SNPs in EGR4 are shown (see all 115)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 2 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs116886411,2
    C,F,H--73517757(+) ATGCGA/GGGATT 1 -- int15Minor allele frequency- G:0.01NS EA NA 420
    rs1129593391,2
    C,F--73517956(+) CAGGGT/CCTGTA 1 -- int12Minor allele frequency- C:0.05CSA WA 119
    rs1433875571,2
    C--73518038(+) CAGGA-/GCT   
      TACATG
    GCAGA
    1 -- int10--------
    rs1464853431,2
    C--73518365(+) CAAAGC/TGCGGC 1 -- ut310--------
    rs75845401,2
    C,F--73518461(+) ACTGGA/GAGCGG 1 -- ut31 ese31Minor allele frequency- G:0.03WA 118
    rs1930166561,2
    --73518485(+) CCCTCA/GGGCGT 1 -- ut310--------
    rs1852916471,2
    C--73518515(+) AGAGCG/TGGGAG 1 -- ut310--------
    rs22292941,2
    C,F,H--73518533(-) GAGTTC/TCGGGC 1 -- ut3126Minor allele frequency- T:0.24MN NA NS EA WA CSA EU 3555
    rs1901645571,2
    --73518567(+) CAACCC/GATAAA 1 -- ut310--------
    rs1484093941,2
    C,F--73518628(+) CGAGGC/GCCTTG 2 A G mis12Minor allele frequency- G:0.00NA EU 5079

    HapMap Linkage Disequilibrium report for EGR4 (73518057 - 73520833 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for EGR4: --
    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing EGR4
    DNA2.0 Custom Variant and Variant Library Synthesis for EGR4

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 128992    OMIM disorders: --

    3 diseases for EGR4:    About MalaCards
    tooth disease    charcot-marie-tooth disease    schizophrenia


    EGR4 for disorders           About GeneDecksing

    Genetic Association Database (GAD): EGR4
    Human Genome Epidemiology (HuGE) Navigator: EGR4 (2 documents)

    Export disorders for EGR4 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for EGR4 gene, integrated from 9 sources (see all 13):
    (articles sorted by number of sources associating them with EGR4)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. No association between EGR gene family polymorphisms and schizophrenia in the Chinese population. (PubMed id 20144677)1, 4 Liu B.C....He G. (2010)
    2. Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PubMed id 15815621)1, 2 Hillier L.W....Wilson R.K. (2005)
    3. Genomic organization, chromosomal localization and promoter function of the human zinc-finger gene pAT133. (PubMed id 8504297)1, 2 Holst C.... Zipfel P.F. (1993)
    4. Neural-specific expression, genomic structure, and chromosomal localization of the gene encoding the zinc-finger transcription factor NGFI-C. (PubMed id 1584812)1, 3 Crosby S.D....Milbrandt J. (1992)
    5. Clone pAT133 identifies a gene that encodes another human member of a class of growth factor-induced genes with almost identical zinc-finger domains. (PubMed id 1658795)1, 2 Mueller H.-J.... Zipfel P.F. (1991)
    6. Genetic and functional analyses of early growth respon se (EGR) family genes in schizophrenia. (PubMed id 22691714)1 Cheng M.C....Chen C.H. (2012)
    7. EGR4 is a master gene responsible for fertility in cr yptorchidism. (PubMed id 19828938)1 Hadziselimovic F....Oakeley E.J. (2009)
    8. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (2006)
    9. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)2 Ota T.... Sugano S. (2004)
    10. Early growth response proteins (EGR) and nuclear factors of activated T cells (NFAT) form heterodimers and regulate proinflammatory cytokine gene expression. (PubMed id 12560487)1 Decker E.L....Skerka C. (2003)

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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 1961 HGNC: 3241 AceView: EGR4 Ensembl:ENSG00000135625 euGenes: HUgn1961
    ECgene: EGR4 H-InvDB: EGR4

    (According to HUGE)
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    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
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    About This Section
    NameDescription
    PharmGKB entry for EGR4 Pharmacogenomics, SNPs, Pathways

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