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Aliases for EGR4 Gene

Aliases for EGR4 Gene

  • Early Growth Response 4 2 3 5
  • AT133 3 4
  • EGR-4 3 4
  • Early Growth Response Protein 4 3
  • NGFI-C 3
  • PAT133 3
  • NGFIC 3

External Ids for EGR4 Gene

Previous GeneCards Identifiers for EGR4 Gene

  • GC02M073527
  • GC02M073728
  • GC02M073493
  • GC02M073494
  • GC02M073430
  • GC02M073253
  • GC02M073518

Summaries for EGR4 Gene

GeneCards Summary for EGR4 Gene

EGR4 (Early Growth Response 4) is a Protein Coding gene. Diseases associated with EGR4 include Cryptorchidism. Among its related pathways are Downstream signaling in naive CD8+ T cells and Calcineurin-regulated NFAT-dependent transcription in lymphocytes. GO annotations related to this gene include transcription factor activity, sequence-specific DNA binding. An important paralog of this gene is EGR2.

UniProtKB/Swiss-Prot for EGR4 Gene

  • Transcriptional regulator. Recognizes and binds to the DNA sequence 5-GCGGGGGCG-3 (GSG). Activates the transcription of target genes whose products are required for mitogenesis and differentiation (By similarity).

Gene Wiki entry for EGR4 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for EGR4 Gene

Genomics for EGR4 Gene

Regulatory Elements for EGR4 Gene

Enhancers for EGR4 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH02F073175 1.3 FANTOM5 Ensembl ENCODE 1.4 +117.1 117051 3.2 HDGF CREB3L1 ZFP64 ARID4B SIN3A DMAP1 ZNF2 YY1 SLC30A9 ZNF143 SMYD5 SFXN5 DUSP11 PRADC1 ENSG00000273245 NOTO SPR EMX1 CCT7 EGR4
GH02F073291 0.2 ENCODE 0.8 +2.4 2398 0.2 ELF3 MLX ARID4B SIN3A ZNF48 ZSCAN9 DNMT3B ZEB1 RARA CHAMP1 SMYD5 FBXO41 EGR4
GH02F073293 0.8 ENCODE 0.8 0.0 -3 0.2 GTF2F1 CTCF ATF1 SUZ12 SAP130 ARID4B MAX SIN3A E2F1 ZNF316 EGR4 RNU6-111P
GH02F073283 0.9 ENCODE 0.4 +9.2 9169 2.7 HDGF ZNF76 SIN3A ARID4B DMAP1 ZNF48 RARA GLIS2 EGR1 ZNF143 FBXO41 EGR4
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around EGR4 on UCSC Golden Path with GeneCards custom track

Promoters for EGR4 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001824158 105 401 GTF2F1 CTCF ATF1 SUZ12 SAP130 ARID4B SIN3A E2F1 ZNF316 GLIS2

Genomic Location for EGR4 Gene

Chromosome:
2
Start:
73,290,929 bp from pter
End:
73,293,705 bp from pter
Size:
2,777 bases
Orientation:
Minus strand

Genomic View for EGR4 Gene

Genes around EGR4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
EGR4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for EGR4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for EGR4 Gene

Proteins for EGR4 Gene

  • Protein details for EGR4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q05215-EGR4_HUMAN
    Recommended name:
    Early growth response protein 4
    Protein Accession:
    Q05215
    Secondary Accessions:
    • B2RAE3
    • G3V1T5
    • Q2Z1P5

    Protein attributes for EGR4 Gene

    Size:
    589 amino acids
    Molecular mass:
    61623 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAX88903.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=BAG36840.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=CAA42698.1; Type=Frameshift; Positions=66; Evidence={ECO:0000305}; Sequence=CAA49214.1; Type=Frameshift; Positions=66; Evidence={ECO:0000305};

neXtProt entry for EGR4 Gene

Post-translational modifications for EGR4 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for EGR4 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for EGR4 Gene

Domains & Families for EGR4 Gene

Gene Families for EGR4 Gene

Protein Domains for EGR4 Gene

Suggested Antigen Peptide Sequences for EGR4 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q05215

UniProtKB/Swiss-Prot:

EGR4_HUMAN :
  • Belongs to the EGR C2H2-type zinc-finger protein family.
  • Contains 3 C2H2-type zinc fingers.
Family:
  • Belongs to the EGR C2H2-type zinc-finger protein family.
Similarity:
  • Contains 3 C2H2-type zinc fingers.
genes like me logo Genes that share domains with EGR4: view

Function for EGR4 Gene

Molecular function for EGR4 Gene

GENATLAS Biochemistry:
immediate early growth response,gene 4 (pAT133),nerve growth factor induced clone C
UniProtKB/Swiss-Prot Function:
Transcriptional regulator. Recognizes and binds to the DNA sequence 5-GCGGGGGCG-3 (GSG). Activates the transcription of target genes whose products are required for mitogenesis and differentiation (By similarity).
UniProtKB/Swiss-Prot Induction:
By PHA/PMA or by serum.

Gene Ontology (GO) - Molecular Function for EGR4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IEA --
GO:0003700 transcription factor activity, sequence-specific DNA binding NAS 1584812
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with EGR4: view
genes like me logo Genes that share phenotypes with EGR4: view

Animal Models for EGR4 Gene

MGI Knock Outs for EGR4:

Animal Model Products

Transcription Factor Targets for EGR4 Gene

Selected GeneGlobe predicted Target genes for EGR4

Inhibitory RNA Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , miRNA and HOMER Transcription for EGR4 Gene

Localization for EGR4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for EGR4 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for EGR4 Gene COMPARTMENTS Subcellular localization image for EGR4 gene
Compartment Confidence
nucleus 5

Gene Ontology (GO) - Cellular Components for EGR4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with EGR4: view

Pathways & Interactions for EGR4 Gene

genes like me logo Genes that share pathways with EGR4: view

Pathways by source for EGR4 Gene

Gene Ontology (GO) - Biological Process for EGR4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0008284 positive regulation of cell proliferation TAS 1658795
genes like me logo Genes that share ontologies with EGR4: view

No data available for SIGNOR curated interactions for EGR4 Gene

Transcripts for EGR4 Gene

mRNA/cDNA for EGR4 Gene

(1) REFSEQ mRNAs :
(4) Additional mRNA sequences :
(8) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for EGR4 Gene

Early growth response 4:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for EGR4 Gene

ExUns: 1a · 1b ^ 2a · 2b
SP1:
SP2:

Relevant External Links for EGR4 Gene

GeneLoc Exon Structure for
EGR4
ECgene alternative splicing isoforms for
EGR4

Expression for EGR4 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for EGR4 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for EGR4 Gene

This gene is overexpressed in Brain - Cerebellar Hemisphere (x8.8), Brain - Cerebellum (x7.0), Brain - Putamen (basal ganglia) (x6.3), Brain - Nucleus accumbens (basal ganglia) (x4.8), and Brain - Caudate (basal ganglia) (x4.5).

NURSA nuclear receptor signaling pathways regulating expression of EGR4 Gene:

EGR4

SOURCE GeneReport for Unigene cluster for EGR4 Gene:

Hs.3052
genes like me logo Genes that share expression patterns with EGR4: view

Primer Products

No data available for Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and mRNA Expression by UniProt/SwissProt for EGR4 Gene

Orthologs for EGR4 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for EGR4 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia EGR4 34 35
  • 99.49 (n)
dog
(Canis familiaris)
Mammalia EGR4 34 35
  • 86.88 (n)
cow
(Bos Taurus)
Mammalia EGR4 34 35
  • 86.86 (n)
rat
(Rattus norvegicus)
Mammalia Egr4 34
  • 85.05 (n)
mouse
(Mus musculus)
Mammalia Egr4 34 16 35
  • 84.98 (n)
oppossum
(Monodelphis domestica)
Mammalia EGR4 35
  • 66 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 57 (a)
ManyToMany
chicken
(Gallus gallus)
Aves EGR4 34 35
  • 60.64 (n)
tropical clawed frog
(Silurana tropicalis)
Amphibia egr4 34
  • 52.2 (n)
zebrafish
(Danio rerio)
Actinopterygii EGR4 (1 of 2) 35
  • 34 (a)
OneToMany
EGR4 (2 of 2) 35
  • 32 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta sr 35
  • 13 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea C27C12.2 36
  • 75 (a)
Y55F3AM.7 36
  • 68 (a)
egrh-3 35
  • 21 (a)
ManyToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes MIG1 35
  • 10 (a)
ManyToMany
MIG2 35
  • 9 (a)
ManyToMany
MIG3 35
  • 9 (a)
ManyToMany
Species where no ortholog for EGR4 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for EGR4 Gene

ENSEMBL:
Gene Tree for EGR4 (if available)
TreeFam:
Gene Tree for EGR4 (if available)

Paralogs for EGR4 Gene

Paralogs for EGR4 Gene

genes like me logo Genes that share paralogs with EGR4: view

Variants for EGR4 Gene

Sequence variations from dbSNP and Humsavar for EGR4 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type
rs112387203 -- 73,293,393(+) GCTGG(C/T)GGTAG reference, synonymous-codon
rs112959339 -- 73,290,828(+) CAGGG(C/T)CTGTA downstream-variant-500B
rs113117246 -- 73,292,438(+) GAGGC(C/T)TCCCA reference, synonymous-codon
rs114378699 -- 73,292,306(+) GCGTA(A/G)GGACC reference, synonymous-codon
rs11453421 -- 73,294,830(+) TTGAG(-/A)AAAAA upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for EGR4 Gene

Variant ID Type Subtype PubMed ID
nsv1013190 CNV loss 25217958

Variation tolerance for EGR4 Gene

Residual Variation Intolerance Score: 47.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.50; 29.18% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for EGR4 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
EGR4

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for EGR4 Gene

Disorders for EGR4 Gene

MalaCards: The human disease database

(1) MalaCards diseases for EGR4 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
cryptorchidism
  • cryptorchism
- elite association - COSMIC cancer census association via MalaCards
Search EGR4 in MalaCards View complete list of genes associated with diseases

Relevant External Links for EGR4

Genetic Association Database (GAD)
EGR4
Human Genome Epidemiology (HuGE) Navigator
EGR4
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
EGR4
genes like me logo Genes that share disorders with EGR4: view

No data available for UniProtKB/Swiss-Prot and Genatlas for EGR4 Gene

Publications for EGR4 Gene

  1. No association between EGR gene family polymorphisms and schizophrenia in the Chinese population. (PMID: 20144677) Liu B.C. … He G. (Prog. Neuropsychopharmacol. Biol. Psychiatry 2010) 3 46 64
  2. Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PMID: 15815621) Hillier L.W. … Wilson R.K. (Nature 2005) 3 4 64
  3. Genomic organization, chromosomal localization and promoter function of the human zinc-finger gene pAT133. (PMID: 8504297) Holst C. … Zipfel P.F. (Hum. Mol. Genet. 1993) 3 4 64
  4. Neural-specific expression, genomic structure, and chromosomal localization of the gene encoding the zinc-finger transcription factor NGFI-C. (PMID: 1584812) Crosby S.D. … Milbrandt J. (Proc. Natl. Acad. Sci. U.S.A. 1992) 2 3 64
  5. Clone pAT133 identifies a gene that encodes another human member of a class of growth factor-induced genes with almost identical zinc-finger domains. (PMID: 1658795) Mueller H.-J. … Zipfel P.F. (Proc. Natl. Acad. Sci. U.S.A. 1991) 3 4 64

Products for EGR4 Gene

Sources for EGR4 Gene

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