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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

EGR4 Gene

protein-coding   GIFtS: 56
GCID: GC02M073518

early growth response 4
 Explore 3 diseases affiliated with
EGR4 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for EGR4    

Aliases
for EGR4 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Early Growth Response 41 2     EGR-42 3
NGFI-C1 2     NGFIC2 5
PAT1331 2     Early Growth Response Protein 42
AT1332 3     

External Ids:    HGNC: 32411   Entrez Gene: 19612   Ensembl: ENSG000001356257   OMIM: 1289925   UniProtKB: Q052153   

Export aliases for EGR4 gene to outside databases

Previous GC identifers: GC02M073527 GC02M073728 GC02M073493 GC02M073494 GC02M073430 GC02M073253


Summaries
for EGR4 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
UniProtKB/Swiss-Prot: EGR4_HUMAN, Q05215
Function: Transcriptional regulator. Recognizes and binds to the DNA sequence 5'-GCGGGGGCG-3' (GSG). Activates the
transcription of target genes whose products are required for mitogenesis and differentiation (By similarity)

Gene Wiki entry for EGR4


Genomic Views
for EGR4 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000002.11  NC_018913.1  NT_022184.15  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the EGR4 gene promoter:
         STAT1   GATA-3   NRSF form 1   MyoD   NRSF form 2   STAT1alpha   CP2   ZIC2/Zic2   Pax-4a   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: EGR4 promoter sequence
   Search SABiosciences Chromatin IP Primers for EGR4

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat EGR4


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2p13   Ensembl cytogenetic band:  2p13.1   HGNC cytogenetic band: 2p13

EGR4 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
EGR4 gene location

GeneLoc information about chromosome 2         GeneLoc Exon Structure

GeneLoc location for GC02M073518:  view genomic region     (about GC identifiers)

Start:
 73,518,057 bp from pter      End:
 73,520,833 bp from pter
Size:
 2,777 bases      Orientation:
 minus strand

Proteins
for EGR4 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: EGR4_HUMAN, Q05215 (See protein sequence)
Recommended Name: Early growth response protein 4  
Size: 486 amino acids; 50799 Da
Subcellular location: Nucleus (Probable)
Secondary accessions: Q2Z1P5

Explore the universe of human proteins at neXtProt for EGR4: NX_Q05215

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q05215

    • EGR4 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_001956.3  
    ENSEMBL proteins: 
     ENSP00000419687   ENSP00000445626  

    Human Recombinant Protein Products: 
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    Novus Biologicals EGR4 Protein
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Uscn Proteins for EGR4

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005622intracellular ----
    GO:0005634nucleus IEA--


    EGR4 for ontologies           About GeneDecksing



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    Uscn ELISAs and CLIAs for EGR4

    Protein Domains /
    Families
    for EGR4 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    EGR4 for domains           About GeneDecksing

    3 InterPro domains/families:
     IPR015880 Znf_C2H2-like
     IPR013087 Znf_C2H2/integrase_DNA-bd
     IPR007087 Znf_C2H2

    Graphical View of Domain Structure for InterPro Entry Q05215

    ProtoNet protein and cluster: Q05215

    1 Blocks protein family: IPB007086 C2H2-type zinc finger signature

    UniProtKB/Swiss-Prot: EGR4_HUMAN, Q05215
    Similarity: Belongs to the EGR C2H2-type zinc-finger protein family
    Similarity: Contains 3 C2H2-type zinc fingers


    Function
    for EGR4 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: EGR4_HUMAN, Q05215
    Function: Transcriptional regulator. Recognizes and binds to the DNA sequence 5'-GCGGGGGCG-3' (GSG). Activates the
    transcription of target genes whose products are required for mitogenesis and differentiation (By similarity)
    Induction: By PHA/PMA or by serum

         Genatlas biochemistry entry for EGR4:
    immediate early growth response,gene 4 (pAT133),nerve growth factor induced clone C

    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat EGR4
    8/17 QIAGEN miScript miRNA Assays for microRNAs that regulate EGR4 (see all 17):
    hsa-miR-100* hsa-miR-4328 hsa-miR-520d-5p hsa-miR-330-5p hsa-miR-637 hsa-miR-326 hsa-miR-330-3p hsa-miR-374b*
    SwitchGear 3'UTR luciferase reporter plasmid: EGR4 3' UTR sequence
    Inhib. RNA
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    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for EGR4 (see all 7)
    OriGene shRNA RFP: EGR4
    OriGene siRNA: EGR4
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat EGR4

    Gene Editing
    Products:    		DNA2.0 Custom Protein Engineering Service for EGR4

    Clone
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    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for EGR4 (see all 4)
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat EGR4 

    Cell Line
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    Search LifeMap BioReagents cell lines for EGR4

    In Situ Assay
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    Gene Ontology (GO): 5 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003676nucleic acid binding ----
    GO:0003677DNA binding IEA--
    GO:0003700sequence-specific DNA binding transcription factor activity NAS1584812
    GO:0008270zinc ion binding IEA--
    GO:0016563transcription activator activity ----


    EGR4 for ontologies           About GeneDecksing


    Animal Models:
         Mouse knock-out Egr4tm1Jmi for EGR4
         4 MGI mutant phenotypes (inferred from 1 allele) (MGI details for Egr4):
     cellular  endocrine/exocrine gland  homeostasis/metabolism  reproductive system 

    EGR4 for phenotypes           About GeneDecksing


    Pathways & Interactions
    for EGR4 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways  About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Downstream signaling in naive CD8+ T cells
    		Downstream signaling in naive CD8+ T cells1.00
    2Calcium signaling in the CD4+ TCR pathway
    		Calcineurin-regulated NFAT-dependent transcription in lymphocytes0.38


    2 BioSystems Pathways for EGR4 
        Calcineurin-regulated NFAT-dependent transcription in lymphocytes
    Downstream signaling in naive CD8+ T cells


    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for EGR4

    STRING Interaction Network Preview (showing 3 interactants - click image to see more details)

    3 Interacting proteins for EGR4 (Q052153 ENSP000004196874) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    NFATC1O956443, ENSP000003278504I2D: score=1 STRING: ENSP00000327850
    NFATC2Q134693, ENSP000003793304I2D: score=1 STRING: ENSP00000379330
    NFATC3ENSP000003006594STRING: ENSP00000300659
    About this table

    Gene Ontology (GO): 4 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006351transcription, DNA-dependent IEA--
    GO:0006355regulation of transcription, DNA-dependent ----
    GO:0008284positive regulation of cell proliferation TAS1658795
    GO:0045893positive regulation of transcription, DNA-dependent ----


    EGR4 for ontologies           About GeneDecksing



    Drugs & Compounds
    for EGR4 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for EGR4
    Search CenterWatch for drugs/clinical trials and news about EGR4 

    Transcripts
    for EGR4 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for EGR4 gene: 
    NM_001965.3  

    Unigene Cluster for EGR4:

    Early growth response 4
    Hs.3052  [show with all ESTs]
    Unigene Representative Sequence: NM_001965
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000436467 ENST00000545030(uc010yrj.2 uc010yrk.1)

    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat EGR4
    8/17 QIAGEN miScript miRNA Assays for microRNAs that regulate EGR4 (see all 17):
    hsa-miR-100* hsa-miR-4328 hsa-miR-520d-5p hsa-miR-330-5p hsa-miR-637 hsa-miR-326 hsa-miR-330-3p hsa-miR-374b*
    SwitchGear 3'UTR luciferase reporter plasmid: EGR4 3' UTR sequence
    Inhib. RNA
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    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for EGR4 (see all 7)
    OriGene shRNA RFP: EGR4
    OriGene siRNA: EGR4
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat EGR4
    Clone
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    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector: EGR4 (NM_001965)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for EGR4
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat EGR4 
    Primer
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat EGR4
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat EGR4

    Additional cDNA sequence: 

    AK314154.1 BC136252.1 BC143379.1 X60104.1 

    2 DOTS entries:

    DT.104276  DT.95199431 

    8 AceView cDNA sequences:

    H42245 BC034462 NM_001965 X60104 BX395919 BM563959 AI223359 BI822363 

    GeneLoc Exon Structure

    2 Alternative Splicing Database (ASD) splice patterns (SP) for EGR4    About this scheme

    ExUns: 1a · 1b ^ 2a · 2b
    SP1:                        
    SP2:                        


    ECgene alternative splicing isoforms for EGR4

    Expression
    for EGR4 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    EGR4 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: TCGGGCATCT

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    EGR4 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    3 LifeMap In Vivo Development Anatomical Compartments/Cells 
    Tissue Anatomical Compartment CellCategory (developmental path)
    PancreasDorsal Pancreatic BudImmature Beta Progenitor CellsPancreas
    PancreasVentral Pancreatic BudImmature Beta Progenitor CellsPancreas
    SomiteThoracic Ventrolateral Dermomyotome LipMuscle Progenitor CellsSkeletal Muscle
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization

    See EGR4 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for EGR4

    SOURCE GeneReport for Unigene cluster: Hs.3052
        SABiosciences Expression via Pathway-Focused PCR Array including EGR4: 
              Synaptic Plasticity in human mouse rat

    Primer
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    In Situ
    Assay Products:     
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    Orthologs
    for EGR4 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of animals.

    Orthologs for EGR4 gene from 4/15 species (see all 15)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    chicken
    (Gallus gallus)    		 Aves EGR41 early growth response 4 62(n)
    56.48(a)    		   422950  XM_420888.1  XP_420888.1 
    zebrafish
    (Danio rerio)    		 Actinopterygii CF998734.12   -- 82.93(n)    CF998734.1 
    fruit fly
    (Drosophila melanogaster)    		 Insecta sr6
    		 stripe
    		 9(a)
    		 1 → many
    		 3R(13916525-13959471)
    worm
    (Caenorhabditis elegans)    		 Secernentea C27C12.23 Zinc finger, C2H2 type (3 domains) 75(a)
    (best of 2)    		   X(14881084-14882208)   --


    ENSEMBL Gene Tree for EGR4 (if available)
    TreeFam Gene Tree for EGR4 (if available) 

    Paralogs
    for EGR4 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for EGR4 gene
    EGR32  EGR12  WT12  EGR22  
    18/28 SIMAP similar genes for EGR4 using alignment to 3 protein entries:     EGR4_HUMAN (see all proteins) (see all similar genes):
    WT1    DKFZp434J0650    DKFZp686N0199    ZNF468    ZFS-5    A-328A3.4
    smap-7    ZNF697    ZNF78L1    DKFZp686M04222    DKFZp686O1631    ZNF740
    ZNF    ZNF138    kr-znf3    ZFS-6    ZNF72    DKFZp547H249

    EGR4 for paralogs           About GeneDecksing



    Genomic Variants
    for EGR4 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/82 NCBI SNPs in EGR4 are shown (see all 82)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 2 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs116886411,2
    		C,F,H,--73517757(+) ATGCGA/GGGATT 1 -- int15Minor allele frequency- G:0.01NS EA NA 420
    rs1129593391,2
    		--73517956(+) CAGGGT/CCTGTA 1 -- int12Minor allele frequency- C:0.05CSA WA 119
    rs1433875571,2
    		C,--73518038(+) CAGGA-/GCT   
      TACATG    GCAGA     		1 -- int10--------
    rs1464853431,2
    		--73518365(+) CAAAGC/TGCGGC 1 -- ut310--------
    rs75845401,2
    		C,F,--73518461(+) ACTGGA/GAGCGG 1 -- ut31 ese31Minor allele frequency- G:0.03WA 118
    rs1930166561,2
    		--73518485(+) CCCTCA/GGGCGT 1 -- ut310--------
    rs1852916471,2
    		--73518515(+) AGAGCG/TGGGAG 1 -- ut310--------
    rs22292941,2
    		C,F,H,--73518533(-) GAGTTC/TCGGGC 1 -- ut3126Minor allele frequency- T:0.24MN NA NS EA WA CSA EU 3555
    rs1901645571,2
    		--73518567(+) CAACCC/GATAAA 1 -- ut310--------
    rs1484093941,2
    		C,F--73518628(+) CGAGGC/GCCTTG 2 A G mis12Minor allele frequency- G:0.00NA EU 5079

    HapMap Linkage Disequilibrium report for EGR4 (73518057 - 73520833 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for EGR4: --

    SABiosciences Cancer Mutation PCR Assays
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing EGR4
    DNA2.0 Custom Variant and Variant Library Synthesis for EGR4

    Disorders / Diseases
    for EGR4 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    EGR4 for disorders           About GeneDecksing

    OMIM gene information: 128992    OMIM disorders: --

    3 diseases for EGR4:    About MalaCards
    charcot-marie-tooth disease    tooth disease    schizophrenia

    Human Genome Epidemiology (HuGE) Navigator: EGR4 (2 documents)

    Export disorders for EGR4 gene to outside databases

    Publications
    for EGR4 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for EGR4 gene, integrated from 9 sources (see all 12):
    (articles sorted by number of sources associating them with EGR4)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PubMed id 15815621)1, 2 Hillier L.W....Wilson R.K. (2005)
    2. Genomic organization, chromosomal localization and promoter function of the human zinc-finger gene pAT133. (PubMed id 8504297)1, 2 Holst C.... Zipfel P.F. (1993)
    3. Neural-specific expression, genomic structure, and chromosomal localization of the gene encoding the zinc-finger transcription factor NGFI-C. (PubMed id 1584812)1, 3 Crosby S.D....Milbrandt J. (1992)
    4. Clone pAT133 identifies a gene that encodes another human member of a class of growth factor-induced genes with almost identical zinc-finger domains. (PubMed id 1658795)1, 2 Mueller H.-J.... Zipfel P.F. (1991)
    5. Genetic and functional analyses of early growth respon se (EGR) family genes in schizophrenia. (PubMed id 22691714)1 Cheng M.C....Chen C.H. (2012)
    6. No association between EGR gene family polymorphisms and schizophrenia in the Chinese population. (PubMed id 20144677)1 Liu B.C....He G. (2010)
    7. EGR4 is a master gene responsible for fertility in cr yptorchidism. (PubMed id 19828938)1 Hadziselimovic F....Oakeley E.J. (2009)
    8. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (2006)
    9. Early growth response proteins (EGR) and nuclear factors of activated T cells (NFAT) form heterodimers and regulate proinflammatory cytokine gene expression. (PubMed id 12560487)1 Decker E.L....Skerka C. (2003)
    10. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)

    External Searches for EGR4 gene

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    Genome Databases showing EGR4 gene

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    Entrez Gene: 1961 HGNC: 3241 AceView: EGR4 Ensembl:ENSG00000135625 euGenes: HUgn1961
    ECgene: EGR4 H-InvDB: EGR4

    Other Databases showing EGR4 gene

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    Specialized Databases showing EGR4 gene

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    PharmGKB entry for EGR4 Pharmacogenomics, SNPs, Pathways

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