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EGR4 Gene

protein-coding   GIFtS: 55
GCID: GC02M073518

Early Growth Response 4

  Search for EGR4
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Early Growth Response 41 2     NGFI-C2
AT1332 3     PAT1332
EGR-42 3     Early Growth Response Protein 42
NGFIC2 5     

External Ids:    HGNC: 32411   Entrez Gene: 19612   Ensembl: ENSG000001356257   OMIM: 1289925   UniProtKB: Q052153   

Export aliases for EGR4 gene to outside databases

Previous GC identifers: GC02M073527 GC02M073728 GC02M073493 GC02M073494 GC02M073430 GC02M073253


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for EGR4 Gene:
EGR4 (early growth response 4) is a protein-coding gene. GO annotations related to this gene include sequence-specific DNA binding transcription factor activity. An important paralog of this gene is EGR3.

UniProtKB/Swiss-Prot: EGR4_HUMAN, Q05215
Function: Transcriptional regulator. Recognizes and binds to the DNA sequence 5'-GCGGGGGCG-3' (GSG). Activates the
transcription of target genes whose products are required for mitogenesis and differentiation (By similarity)

Gene Wiki entry for EGR4 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000002.11  NC_018913.2  NT_022184.16  
Regulatory elements:
   Regulatory transcription factor binding sites in the EGR4 gene promoter:
         STAT1   GATA-3   NRSF form 1   MyoD   NRSF form 2   STAT1alpha   CP2   ZIC2/Zic2   Pax-4a   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidEGR4 promoter sequence
   Search Chromatin IP Primers for EGR4

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat EGR4


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2p13   Ensembl cytogenetic band:  2p13.1   HGNC cytogenetic band: 2p13

EGR4 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
EGR4 gene location

GeneLoc information about chromosome 2         GeneLoc Exon Structure

GeneLoc location for GC02M073518:  view genomic region     (about GC identifiers)

Start:
73,518,057 bp from pter      End:
73,520,833 bp from pter
Size:
2,777 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: EGR4_HUMAN, Q05215 (See protein sequence)
Recommended Name: Early growth response protein 4  
Size: 589 amino acids; 61623 Da
Caution: It is uncertain whether Met-1 or Met-104 is the initiator. Some orthologous sequences can not be extended
Sequence caution: Sequence=AAX88903.1; Type=Erroneous initiation; Note=Translation N-terminally extended;
Sequence=BAG36840.1; Type=Erroneous initiation; Note=Translation N-terminally extended; Sequence=CAA42698.1;
Type=Frameshift; Positions=66; Sequence=CAA49214.1; Type=Frameshift; Positions=66;
Secondary accessions: B2RAE3 G3V1T5 Q2Z1P5

Explore the universe of human proteins at neXtProt for EGR4: NX_Q05215

Explore proteomics data for EGR4 at MOPED


See EGR4 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

REFSEQ proteins: NP_001956.3  
ENSEMBL proteins: 
 ENSP00000419687   ENSP00000445626  

EGR4 Human Recombinant Protein Products:

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OriGene Protein Over-expression Lysate for EGR4
OriGene Custom MassSpec
OriGene Custom Protein Services for EGR4
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Novus Biologicals EGR4 Protein
Browse Sino Biological Recombinant Proteins
Browse Sino Biological Cell Lysates
Browse ProSpec Recombinant Proteins
Cloud-Clone Corp. Proteins for EGR4

 
Search eBioscience for Proteins for EGR4 

EGR4 Antibody Products:

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Novus Biologicals EGR4 Antibodies
Abcam antibodies for EGR4
Cloud-Clone Corp. Antibodies for EGR4
ThermoFisher Antibodies for EGR4
LSBio Antibodies in human, mouse, rat for EGR4

EGR4 Assay Products:

Browse Kits and Assays available from EMD Millipore
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GenScript Custom Assay Services for EGR4
Browse Enzo Life Sciences for kits & assays
Cloud-Clone Corp. ELISAs for EGR4
Cloud-Clone Corp. CLIAs for EGR4
Search eBioscience for ELISAs for EGR4 


(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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HGNC Gene Families:
ZNF: Zinc fingers, C2H2-type

3 InterPro protein domains:
 IPR015880 Znf_C2H2-like
 IPR013087 Znf_C2H2/integrase_DNA-bd
 IPR007087 Znf_C2H2

Graphical View of Domain Structure for InterPro Entry Q05215

ProtoNet protein and cluster: Q05215

1 Blocks protein domain: IPB007086 C2H2-type zinc finger signature

UniProtKB/Swiss-Prot: EGR4_HUMAN, Q05215
Similarity: Belongs to the EGR C2H2-type zinc-finger protein family
Similarity: Contains 3 C2H2-type zinc fingers


Find genes that share domains with EGR4           About GenesLikeMe


(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Molecular Function:

     UniProtKB/Swiss-Prot Summary: EGR4_HUMAN, Q05215
Function: Transcriptional regulator. Recognizes and binds to the DNA sequence 5'-GCGGGGGCG-3' (GSG). Activates the
transcription of target genes whose products are required for mitogenesis and differentiation (By similarity)
Induction: By PHA/PMA or by serum

     Genatlas biochemistry entry for EGR4:
immediate early growth response,gene 4 (pAT133),nerve growth factor induced clone C

     Gene Ontology (GO): 3 molecular function terms:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0003677DNA binding IEA--
GO:0003700sequence-specific DNA binding transcription factor activity NAS1584812
GO:0046872metal ion binding IEA--
     
Find genes that share ontologies with EGR4           About GenesLikeMe


Phenotypes:
     4 MGI mutant phenotypes (inferred from 1 allele(MGI details for Egr4):
 cellular  endocrine/exocrine gland  homeostasis/metabolism  reproductive system 

Find genes that share phenotypes with EGR4           About GenesLikeMe

Animal Models:
     MGI mouse knock-out Egr4tm1Jmi for EGR4

   inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for EGR4
   inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for EGR4

   genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for EGR4
   genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for EGR4

Transcription Factor Targeting: 
Selected GeneGlobe predicted Target genes for EGR4 (see all 385):
ACBD3,  ACTL6B,  ADAMTSL3,  ADCY8,  AGAP10,  AGAP9,  AGFG2,  AKR1B10,  AKR7A2,  AMMECR1

miRNA
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Block miRNA regulation of human, mouse, rat EGR4 using miScript Target Protectors
Selected qRT-PCR Assays for microRNAs that regulate EGR4 (see all 17):
hsa-miR-100* hsa-miR-4328 hsa-miR-520d-5p hsa-miR-330-5p hsa-miR-637 hsa-miR-326 hsa-miR-330-3p hsa-miR-374b*
SwitchGear 3'UTR luciferase reporter plasmidEGR4 3' UTR sequence
Inhib. RNA
Products:
    
OriGene RNAi products in human, mouse, rat for EGR4
Predesigned siRNA for gene silencing in human, mouse, rat EGR4

Gene Editing
Products:
DNA2.0 Custom Protein Engineering Service for EGR4

Clone
Products:
     
OriGene clones in human, mouse for EGR4 (see all 8)
OriGene ORF clones in mouse, rat for EGR4
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
GenScript: all cDNA clones in your preferred vector: EGR4 (NM_001965)
Browse Sino Biological Human cDNA Clones
DNA2.0 Custom Codon Optimized Gene Synthesis Service for EGR4
Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat EGR4

Cell Line
Products:
     
GenScript Custom overexpressing Cell Line Services for EGR4
Browse ESI BIO Cell Lines and PureStem Progenitors for EGR4 
In Situ Assay
Products:
   

 
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for EGR4


(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Subcellular locations from UniProtKB/Swiss-Prot
EGR4_HUMAN, Q05215: Nucleus (Probable)
Subcellular locations from COMPARTMENTS: 

CompartmentConfidence
nucleus4
cytosol1

Gene Ontology (GO): 2 cellular component terms:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0005634nucleus IBA--
GO:0005737cytoplasm IBA--

Find genes that share ontologies with EGR4           About GenesLikeMe


(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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SuperPaths for EGR4 About    
See pathways by source

SuperPathContained pathways About
1Calcineurin-regulated NFAT-dependent transcription in lymphocytes
Calcineurin-regulated NFAT-dependent transcription in lymphocytes0.38
2Downstream signaling in naive CD8+ T cells
Downstream signaling in naive CD8+ T cells


2 BioSystems Pathways for EGR4
    Calcineurin-regulated NFAT-dependent transcription in lymphocytes
Downstream signaling in naive CD8+ T cells


    Pathway & Disease-focused RT2 Profiler PCR Array including EGR4: 
          Synaptic Plasticity in human mouse rat

Interactions:

    Search GeneGlobe Interaction Network for EGR4

STRING Interaction Network Preview (showing 3 interactants - click image to see more details)

3 Interacting proteins for EGR4 (Q052153 ENSP000004196874) via UniProtKB, MINT, STRING, and/or I2D
InteractantInteraction Details
GeneCardExternal ID(s)
NFATC1O956443, ENSP000003278504I2D: score=1 STRING: ENSP00000327850
NFATC2Q134693, ENSP000003793304I2D: score=1 STRING: ENSP00000379330
NFATC3ENSP000003006594STRING: ENSP00000300659
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Gene Ontology (GO): 5 biological process terms:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0006351transcription, DNA-templated IEA--
GO:0008284positive regulation of cell proliferation TAS1658795
GO:0043066negative regulation of apoptotic process IBA--
GO:0071320cellular response to cAMP IBA--
GO:0071371cellular response to gonadotropin stimulus IBA--

Find genes that share ontologies with EGR4           About GenesLikeMe



(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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Browse Small Molecules at EMD Millipore
   Browse drugs & compounds from Enzo Life Sciences
  Browse compounds at ApexBio 

Browse Tocris compounds for EGR4



(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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REFSEQ mRNAs for EGR4 gene: 
NM_001965.3  

Unigene Cluster for EGR4:

Early growth response 4
Hs.3052  [show with all ESTs]
Unigene Representative Sequence: NM_001965
2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
ENST00000436467 ENST00000545030(uc010yrj.2 uc010yrk.1)
miRNA
Products:
     
Block miRNA regulation of human, mouse, rat EGR4 using miScript Target Protectors
Selected qRT-PCR Assays for microRNAs that regulate EGR4 (see all 17):
hsa-miR-100* hsa-miR-4328 hsa-miR-520d-5p hsa-miR-330-5p hsa-miR-637 hsa-miR-326 hsa-miR-330-3p hsa-miR-374b*
SwitchGear 3'UTR luciferase reporter plasmidEGR4 3' UTR sequence
Inhib. RNA
Products:
     
OriGene RNAi products in human, mouse, rat for EGR4
Predesigned siRNA for gene silencing in human, mouse, rat EGR4
Clone
Products:
     
OriGene clones in human, mouse for EGR4 (see all 8)
OriGene ORF clones in mouse, rat for EGR4
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
GenScript: all cDNA clones in your preferred vector: EGR4 (NM_001965)
DNA2.0 Custom Codon Optimized Gene Synthesis Service for EGR4
Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat EGR4
Primer
Products:
    
OriGene qSTAR qPCR primer pairs in human, mouse for EGR4
Pre-validated RT2 qPCR Primer Assay in human, mouse, rat EGR4
  QuantiTect SYBR Green Assays in human, mouse, rat EGR4
  QuantiFast Probe-based Assays in human, mouse, rat EGR4

Additional mRNA sequence: 

AK314154.1 BC136252.1 BC143379.1 X60104.1 

2 DOTS entries:

DT.104276  DT.95199431 

8 AceView cDNA sequences:

BC034462 H42245 NM_001965 X60104 BX395919 AI223359 BM563959 BI822363 

GeneLoc Exon Structure

2 Alternative Splicing Database (ASD) splice patterns (SP) for EGR4    About this scheme

ExUns: 1a · 1b ^ 2a · 2b
SP1:                        
SP2:                        


ECgene alternative splicing isoforms for EGR4

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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EGR4 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>2/3
CGAP TAG: TCGGGCATCT
EGR4 Expression
About this image


EGR4 expression in embryonic tissues and stem cells    About this table
Data from LifeMap, the Embryonic Development and Stem Cells Database
 selected tissues (see all 3) fully expand
 
 Skeletal Muscle (Muscoskeletal System)
         Muscle Progenitor Cells Thoracic Ventrolateral Dermomyotome Lip
 
 Somite (Muscoskeletal System)
         Muscle Progenitor Cells Thoracic Ventrolateral Dermomyotome Lip
 
 Dermis (Integumentary System)
EGR4 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

EGR4 Protein Expression

SOURCE GeneReport for Unigene cluster: Hs.3052
    Pathway & Disease-focused RT2 Profiler PCR Array including EGR4: 
          Synaptic Plasticity in human mouse rat

Primer
Products:
OriGene qSTAR qPCR primer pairs in human, mouse for EGR4
Pre-validated RT2 qPCR Primer Assay in human, mouse, rat EGR4
QuantiTect SYBR Green Assays in human, mouse, rat EGR4
QuantiFast Probe-based Assays in human, mouse, rat EGR4
In Situ
Assay Products:
 

 
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for EGR4

(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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This gene was present in the common ancestor of animals and fungi.

Orthologs for EGR4 gene from Selected species (see all 13)    About this table
Organism Taxonomic
classification
Gene Description Human
Similarity
Orthology
Type
Details
mouse
(Mus musculus)
Mammalia Egr41 , 5 early growth response 41, 5 84.98(n)1
86.37(a)1
  6 (37.48 cM)5
136561  NM_020596.21  NP_065621.11 
 855111225 
chicken
(Gallus gallus)
Aves EGR41 early growth response 4 60.64(n)
54.01(a)
  422950  XM_420888.2  XP_420888.1 
tropical clawed frog
(Xenopus tropicalis)
Amphibia egr41 early growth response 4 52.2(n)
45.37(a)
  100487839  XM_004911289.1  XP_004911346.1 
zebrafish
(Danio rerio)
Actinopterygii CF998734.12   -- 82.93(n)    CF998734.1 
fruit fly
(Drosophila melanogaster)
Insecta sr6
stripe
13(a)
1 → many
3R(13916525-13959471)
worm
(Caenorhabditis elegans)
Secernentea C27C12.23 Zinc finger, C2H2 type (3 domains) 75(a)
(best of 2)
  X(14881084-14882208)   --
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes MIG26
MIG36
(see all 3)
Protein containing zinc fingers, involved in repre...
Probable transcriptional repressor involved in res...
(see all 3)
9(a)
9(a)
(see all 3)
many ↔ many
many ↔ many
(see all 3)
VII(95858-97006) YGL209W
V(210692-211876) YER028C


ENSEMBL Gene Tree for EGR4 (if available)
TreeFam Gene Tree for EGR4 (if available)

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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Paralogs for EGR4 gene
EGR32  EGR12  WT12  EGR22  
Selected SIMAP similar genes for EGR4 using alignment to 2 protein entries:     EGR4_HUMAN (see all proteins) (see all similar genes):
WT1    DKFZp434J0650    DKFZp686N0199    ZNF468    ZFS-5    A-328A3.4
smap-7    ZNF697    ZNF78L1    DKFZp686M04222    DKFZp686O1631    ZNF740
ZNF    ZNF138    kr-znf3    ZFS-6    ZNF72    DKFZp547H249

Find genes that share paralogs with EGR4           About GenesLikeMe



(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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Selected SNPs for EGR4 (see all 115)    About this table                                 

Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidClinical
significance
Chr 2 posSequence#AA
Chg
TypeMore#Allele
freq
PopTotal
sample
More
----------
rs116886411,2
C,F,H--73517757(+) ATGCGA/GGGATT 1 -- int15Minor allele frequency- G:0.01NS EA NA 420
rs1129593391,2
C,F--73517956(+) CAGGGT/CCTGTA 1 -- int12Minor allele frequency- C:0.05CSA WA 119
rs1433875571,2
C--73518038(+) CAGGA-/GCT   
  TACATG
GCAGA
1 -- int10--------
rs1464853431,2
C--73518365(+) CAAAGC/TGCGGC 1 -- ut310--------
rs75845401,2
C,F--73518461(+) ACTGGA/GAGCGG 1 -- ut31 ese31Minor allele frequency- G:0.03WA 118
rs1930166561,2
--73518485(+) CCCTCA/GGGCGT 1 -- ut310--------
rs1852916471,2
C--73518515(+) AGAGCG/TGGGAG 1 -- ut310--------
rs22292941,2
C,F,H--73518533(-) GAGTTC/TCGGGC 1 -- ut3126Minor allele frequency- T:0.24MN NA NS EA WA CSA EU 3555
rs1901645571,2
--73518567(+) CAACCC/GATAAA 1 -- ut310--------
rs1484093941,2
C,F--73518628(+) CGAGGC/GCCTTG 2 A G mis12Minor allele frequency- G:0.00NA EU 5079

HapMap Linkage Disequilibrium report for EGR4 (73518057 - 73520833 bp)

Structural Variations
      Database of Genomic Variants (DGV) variations for EGR4: --
Site Specific Mutation Identification with PCR Assays
SeqTarget long-range PCR primers for resequencing EGR4
DNA2.0 Custom Variant and Variant Library Synthesis for EGR4

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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OMIM gene information: 128992    OMIM disorders: --


Find genes that share disorders with EGR4           About GenesLikeMe

Genetic Association Database (GAD): EGR4
Human Genome Epidemiology (HuGE) Navigator: EGR4 (2 documents)

Export disorders for EGR4 gene to outside databases

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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PubMed articles for EGR4 gene, integrated from 10 sources (see all 13):
(articles sorted by number of sources associating them with EGR4)
    Utopia: connect your pdf to the dynamic
world of online information

  1. No association between EGR gene family polymorphisms and schizophrenia in the Chinese population. (PubMed id 20144677)1, 4 Liu B.C....He G. (amp 2010)
  2. Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PubMed id 15815621)1, 2 Hillier L.W.... Wilson R.K. (Nature 2005)
  3. Genomic organization, chromosomal localization and promoter function of the human zinc-finger gene pAT133. (PubMed id 8504297)1, 2 Holst C.... Zipfel P.F. (Hum. Mol. Genet. 1993)
  4. Neural-specific expression, genomic structure, and chromosomal localization of the gene encoding the zinc-finger transcription factor NGFI-C. (PubMed id 1584812)1, 3 Crosby S.D....Milbrandt J. (Proc. Natl. Acad. Sci. U.S.A. 1992)
  5. Clone pAT133 identifies a gene that encodes another human member of a class of growth factor-induced genes with almost identical zinc-finger domains. (PubMed id 1658795)1, 2 Mueller H.-J.... Zipfel P.F. (Proc. Natl. Acad. Sci. U.S.A. 1991)
  6. Genetic and functional analyses of early growth response (EGR) family genes in schizophrenia. (PubMed id 22691714)1 Cheng M.C....Chen C.H. (amp 2012)
  7. EGR4 is a master gene responsible for fertility in cryptorchidism. (PubMed id 19828938)1 Hadziselimovic F....Oakeley E.J. (Sex Dev 2009)
  8. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (Genome Res. 2006)
  9. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)2 Ota T.... Sugano S. (Nat. Genet. 2004)
  10. Early growth response proteins (EGR) and nuclear factors of activated T cells (NFAT) form heterodimers and regulate proinflammatory cytokine gene expression. (PubMed id 12560487)1 Decker E.L....Skerka C. (Nucleic Acids Res. 2003)

(in PubMed, OMIM, and NCBI Bookshelf)
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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 1961 HGNC: 3241 AceView: EGR4 Ensembl:ENSG00000135625 euGenes: HUgn1961
ECgene: EGR4 H-InvDB: EGR4

(According to HUGE)
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(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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NameDescription
PharmGKB entry for EGR4 Pharmacogenomics, SNPs, Pathways

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from LifeMap Sciences, Inc.)
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Patent Information for EGR4 gene:
Search GeneIP for patents involving EGR4

GeneCards and IP:
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