EGR3 Gene

Aliases
for EGR3 gene

Previous GC identifers: GC08P022058 GC08M022898 GC08M022365 GC08M022567 GC08M022601 GC08M021088

Summaries
for EGR3 gene

Genomic Views
for EGR3 gene

RefSeq DNA sequence:

NC_000008.10  NC_018919.1  NT_167187.1  

SwitchGear Promoter luciferase reporter plasmid: EGR3 promoter sequence

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat EGR3

EGR3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)


GeneLoc information about chromosome 8         GeneLoc Exon Structure

GeneLoc location for GC08M022545:  view genomic region     (about GC identifiers)

Proteins
for EGR3 gene

Explore the universe of human proteins at neXtProt for EGR3: NX_Q06889

Post-translational modifications:

	Browse Purified and Recombinant Proteins at EMD Millipore
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	Browse recombinant and purified proteins available from Enzo Life Sciences
	Browse OriGene full length recombinant human proteins expressed in human HEK293 cells OriGene Protein Over-expression Lysate: EGR3 OriGene Custom Protein Services for EGR3
	GenScript Custom Purified and Recombinant Proteins Services for EGR3
	Novus Biologicals EGR3 Lysate
	Browse Sino Biological Recombinant Proteins
	Browse ProSpec Recombinant Proteins
	Uscn Proteins for EGR3

Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

	Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
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	Cell Signaling Technology (CST) Antibodies for EGR3
	Browse OriGene Antibodies OriGene Custom Antibody Services for EGR3
	GenScript Custom Superior Antibodies Services for EGR3
	Novus Biologicals EGR3 Antibodies
	Abcam antibodies for EGR3
	Uscn Antibodies for EGR3
	Search ThermoFisher Antibodies for EGR3

	Browse Kits and Assays available from EMD Millipore
	OriGene Custom Immunoassay Development Browse OriGene Fluorogenic Cell Assay Kits
	Browse R&D Systems for biochemical assays
	GenScript Custom Assay Services for EGR3
	Browse Enzo Life Sciences for kits & assays
	Uscn ELISAs and CLIAs for EGR3

Protein Domains /
Families
for EGR3 gene

ProtoNet protein and cluster: Q06889

Function
for EGR3 gene

miRNA Products:		miRTarBase miRNAs that target EGR3: hsa-let-7a (MIRT004963)
		OriGene 3'-UTR Clone: EGR3 Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat EGR3
		8/145 QIAGEN miScript miRNA Assays for microRNAs that regulate EGR3 (see all 145):
		hsa-miR-132* hsa-miR-106a hsa-miR-128 hsa-miR-605 hsa-miR-508-5p hsa-miR-200b hsa-miR-130b hsa-miR-130a*
		SwitchGear 3'UTR luciferase reporter plasmid: EGR3 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for EGR3 (see all 7) OriGene shRNA RFP: EGR3 OriGene siRNA: EGR3
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat EGR3

Gene Editing Products:

DNA2.0 Custom Protein Engineering Service for EGR3

Clone Products:		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for EGR3 (see all 3) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for EGR3 OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector (see all 3): EGR3 (NM_004430)
		Browse Sino Biological Human cDNA Clones
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for EGR3
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat EGR3

Cell Line Products:		GenScript Custom overexpressing Cell Line Services for EGR3
		Search LifeMap BioReagents cell lines for EGR3

In Situ Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for EGR3

Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view):    About this table

(inferred from 2 alleles) (MGI details for Egr3)

Pathways & Interactions
for EGR3 gene

	Super-pathway	contained gene-specific pathways
1	Neuroscience	Neuroscience 1.00
2	Calcium signaling in the CD4+ TCR pathway	Calcineurin-regulated NFAT-dependent transcription in lymphocytes 0.38

1 Cell Signaling Technology (CST) Pathway for EGR3

Neuroscience

1 BioSystems Pathway for EGR3

Calcineurin-regulated NFAT-dependent transcription in lymphocytes

Gene Ontology (GO): 5/12 biological process terms (GO ID links to tree view) (see all 12):    About this table

Drugs & Compounds
for EGR3 gene

Transcripts
for EGR3 gene

Expression
for EGR3 gene

EGR3 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: ATAATTGAGT

2 LifeMap In Vivo Development Anatomical Compartments/Cells
	Tissue Anatomical Compartment Cell			Category (developmental path)
	OvaryAntral FollicleMature Granulosa Cells			Ovary
	SomiteThoracic Ventrolateral Dermomyotome LipMuscle Progenitor Cells			Skeletal Muscle
Expression: Positive    Negative     Selective marker Experimental details: Curated     Microarrays     In-situ hybridization

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for EGR3 Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT2 qPCR Primer Assay in human, mouse, rat EGR3
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat EGR3
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat EGR3

In Situ Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for EGR3

Orthologs
for EGR3 gene

Paralogs
for EGR3 gene

Paralogs for EGR3 gene

EGR1²  EGR4²  WT1²  EGR2²  

3 SIMAP similar genes for EGR3 using alignment to 2 protein entries:     EGR3_HUMAN (see all proteins):

EGR1    EGR2    ZNF323

EGR3 for paralogs           About GeneDecksing

Genomic Variants
for EGR3 gene

10/77 NCBI SNPs in EGR3 are shown (see all 77)     About this table

Genomic Data					Transcription Related Data				Allele Frequencies
SNP ID	Valid	Clinical significance	Chr 8 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
-1st2nd3rd	-1st2nd3rd	-1st2nd3rd	-1st2nd3rd	--	--	--	-1st2nd3rd	--	--	-1st2nd3rd	-1st2nd3rd	-1st2nd3rd
rs1420325241,2		--	22544803(+)	GTCTCC/TAGAGA	3	--	int1		0	--	--	--	--
rs1461504921,2		--	22544830(+)	GGAGAC/TCTCCT	3	--	int1		0	--	--	--	--
rs1401473681,2		--	22544858(+)	ACCCAC/TTGGAA	3	--	int1		0	--	--	--	--
rs1129577431,2	F,	--	22544906(+)	CCCTGA/GCTCCC	3	--	int1		3		CSA WA	122
rs1421180261,2		--	22544932(+)	CTGTTC/GGCCTA	3	--	int1		0	--	--	--	--
rs1463386321,2		--	22545044(+)	ACAAAA/GTTCTG	3	--	int1		0	--	--	--	--
rs38336881,2	C	--	22545638(+)	GTTGC-/TTTTTT	3	--	ut31 trp3		0	--	--	--	--
rs1864646411,2		--	22545753(+)	AACAAA/GGGAAA	3	--	ut31		0	--	--	--	--
rs1173028651,2	C,F,	--	22545840(+)	TCTAGC/TTTGGA	3	--	ut31		1		NA	120
rs1891115131,2		--	22546035(+)	TCTTCA/GATATC	3	--	ut31		0	--	--	--	--

HapMap Linkage Disequilibrium report for EGR3 (22545172 - 22550815 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 3 variations for EGR3
     3 CNVs: 2746 3726 31436
Human Gene Mutation Database (HGMD): EGR3

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing EGR3

DNA2.0 Custom Variant and Variant Library Synthesis for EGR3

Disorders / Diseases
for EGR3 gene

14 diseases for EGR3

1 Novoseek disease relationship for EGR3 gene    About this table

Publications
for EGR3 gene

PubMed articles for EGR3 gene, integrated from 9 sources (see all 53): (articles sorted by number of sources associating them with EGR3)

Utopia: connect your pdf to the dynamic world of online information

1. EGR3, a novel member of the Egr family of genes encoding immediate- early transcription factors. (PubMed id 1906159)^{1, 2, 3, 9} Patwardhan S.... Sukhatme V.P. (1991)
2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
3. HIV Tat binds Egr proteins and enhances Egr-dependent transactivation of the Fas ligand promoter. (PubMed id 11909874)^{1, 3} Yang Y....Ashwell J.D. (2002)
4. Expression of PILOT, a putative transcription factor, requires two signals and is cyclosporin A sensitive in T cells. (PubMed id 8443122)^{1, 2} Mages H.W.... Kroczek R.A. (1993)
5. Vascular endothelial growth factor activation of endo thelial cells is mediated by early growth response-3. (PubMed id 19965691)^{1, 9} Suehiro J....Minami T. (2010)
6. The zinc-finger transcription factor, early growth response 3, mediates VEGF-induced angiogenesis. (PubMed id 18059339)^{1, 9} Liu D....Zachary I. (2008)
7. Transcription factor EGR3 is involved in the estrogen-signaling pathway in breast cancer cells. (PubMed id 15171706)^{1, 9} Inoue A....Hayashi S.I. (2004)
8. Vascular endothelial growth factor-regulated gene expression in endothelial cells: KDR-mediated induction of Egr3 and the related nuclear receptors Nur77, Nurr1, and Nor1. (PubMed id 14525795)^{1, 9} Liu D....Zachary I. (2003)
9. Family-based association study of early growth respons e gene 3 with child bipolar I disorder. (PubMed id 22370066)¹ Gallitano A.L....Geller B. (2012)
10. Genetic evidence for the association between the early growth response 3 (EGR3) gene and schizophrenia. (PubMed id 22276163)¹ Zhang R....Ma J. (2012)

External Searches for EGR3 gene

Genome Databases showing EGR3 gene

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Specialized Databases showing EGR3 gene

Products
for EGR3 gene