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EGR3 Gene

protein-coding   GIFtS: 60
GCID: GC08M022545

Early Growth Response 3

  See EGR3-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Early Growth Response 31 2
Zinc Finger Protein Pilot1 2 3
EGR-32 3
PILOT2 3
Early Growth Response Protein 32

External Ids:    HGNC: 32401   Entrez Gene: 19602   Ensembl: ENSG000001793887   OMIM: 6024195   UniProtKB: Q068893   

Export aliases for EGR3 gene to outside databases

Previous GC identifers: GC08P022058 GC08M022898 GC08M022365 GC08M022567 GC08M022601 GC08M021088


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for EGR3 Gene:
This gene encodes a transcriptional regulator that belongs to the EGR family of C2H2-type zinc-finger proteins. It
is an immediate-early growth response gene which is induced by mitogenic stimulation. The protein encoded by this
gene participates in the transcriptional regulation of genes in controling biological rhythm. It may also play a
role in a wide variety of processes including muscle development, lymphocyte development, endothelial cell growth
and migration, and neuronal development. Alternative splicing results in multiple transcript variants encoding
distinct isoforms.(provided by RefSeq, Dec 2010)

GeneCards Summary for EGR3 Gene:
EGR3 (early growth response 3) is a protein-coding gene. Diseases associated with EGR3 include chondromalacia, and chondromalacia patellae. GO annotations related to this gene include sequence-specific DNA binding transcription factor activity. An important paralog of this gene is EGR1.

UniProtKB/Swiss-Prot: EGR3_HUMAN, Q06889
Function: Probable transcription factor involved in muscle spindle development

Gene Wiki entry for EGR3 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000008.10  NT_167187.2  NC_018919.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the EGR3 gene promoter:
         Nkx3-1 v2   Nkx3-1   PPAR-alpha   AREB6   HSF2   Nkx3-1 v1   c-Ets-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidEGR3 promoter sequence
   Search Chromatin IP Primers for EGR3

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat EGR3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 8p23-p21   Ensembl cytogenetic band:  8p21.3   HGNC cytogenetic band: 8p23-p21

EGR3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
EGR3 gene location

GeneLoc information about chromosome 8         GeneLoc Exon Structure

GeneLoc location for GC08M022545:  view genomic region     (about GC identifiers)

Start:
22,545,172 bp from pter      End:
22,550,815 bp from pter
Size:
5,644 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: EGR3_HUMAN, Q06889 (See protein sequence)
Recommended Name: Early growth response protein 3  
Size: 387 amino acids; 42613 Da
Developmental stage: In T-cells, expressed 20 minutes following activation
Secondary accessions: A8K8U9 B4DHJ5 E7EW38 Q2M3W2
Alternative splicing: 2 isoforms:  Q06889-1   Q06889-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for EGR3: NX_Q06889

Explore proteomics data for EGR3 at MOPED


See EGR3 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

REFSEQ proteins (3 alternative transcripts): 
NP_001186809.1  NP_001186810.1  NP_004421.2  

ENSEMBL proteins: 
 ENSP00000318057   ENSP00000430310   ENSP00000429370  

EGR3 Human Recombinant Protein Products:

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OriGene Purified Protein for EGR3
OriGene Protein Over-expression Lysate for EGR3
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Novus Biologicals EGR3 Lysate
Browse Sino Biological Recombinant Proteins
Browse Sino Biological Cell Lysates
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Cloud-Clone Corp. Proteins for EGR3

 
Search eBioscience for Proteins for EGR3 

 
antibodies-online proteins for EGR3 (4 products) 

 
antibodies-online peptides for EGR3

EGR3 Antibody Products:

Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
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Cell Signaling Technology (CST) Antibodies for EGR3 
OriGene Antibodies for EGR3
OriGene Custom Antibody Services for EGR3
Novus Biologicals EGR3 Antibodies
Abcam antibodies for EGR3
Cloud-Clone Corp. Antibodies for EGR3
Search ThermoFisher Antibodies for EGR3
antibodies-online antibodies for EGR3 (37 products) 

EGR3 Assay Products:

Browse Kits and Assays available from EMD Millipore
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GenScript Custom Assay Services for EGR3
Browse Enzo Life Sciences for kits & assays
Cloud-Clone Corp. ELISAs for EGR3
Cloud-Clone Corp. CLIAs for EGR3
Search eBioscience for ELISAs for EGR3 
antibodies-online kits for EGR3 (25 products) 


(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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HGNC Gene Families:
ZNF: Zinc fingers, C2H2-type

4 InterPro protein domains:
 IPR015880 Znf_C2H2-like
 IPR013087 Znf_C2H2/integrase_DNA-bd
 IPR007087 Znf_C2H2
 IPR021849 DUF3446

Graphical View of Domain Structure for InterPro Entry Q06889

ProtoNet protein and cluster: Q06889

1 Blocks protein domain: IPB007086 C2H2-type zinc finger signature

UniProtKB/Swiss-Prot: EGR3_HUMAN, Q06889
Similarity: Belongs to the EGR C2H2-type zinc-finger protein family
Similarity: Contains 3 C2H2-type zinc fingers


Find genes that share domains with EGR3           About GenesLikeMe


(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Molecular Function:

     UniProtKB/Swiss-Prot Summary: EGR3_HUMAN, Q06889
Function: Probable transcription factor involved in muscle spindle development

     Genatlas biochemistry entry for EGR3:
immediate early growth response,gene 3,homologous to EGR1,EGR2

     Gene Ontology (GO): 3 molecular function terms:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0003677DNA binding IEA--
GO:0003700sequence-specific DNA binding transcription factor activity TAS1906159
GO:0046872metal ion binding IEA--
     
Find genes that share ontologies with EGR3           About GenesLikeMe


Phenotypes:
     1 GenomeRNAi human phenotype for EGR3:
 Synthetic lethal with imatinib 

     8 MGI mutant phenotypes (inferred from 5 alleles(MGI details for Egr3):
 behavior/neurological  homeostasis/metabolism  mortality/aging  muscle  nervous system 
 no phenotypic analysis  skeleton  vision/eye 

Find genes that share phenotypes with EGR3           About GenesLikeMe

Animal Models:
     MGI mouse knock-out Egr3tm1Jmi for EGR3

   genOway: Develop your customized and physiologically relevant rodent model for EGR3

Transcription Factor Targeting: 
Selected GeneGlobe predicted Target genes for EGR3 (see all 271):
ABHD12,  ABLIM2,  ACSL4,  ACVR2B,  ADM2,  AKIRIN2,  ANKRD33B,  APOO,  ARRDC5,  ASB6

miRNA
Products:
    
miRTarBase miRNAs that target EGR3:
hsa-mir-26b-5p (MIRT029689), hsa-mir-335-5p (MIRT018262), hsa-let-7a-5p (MIRT004963)

Block miRNA regulation of human, mouse, rat EGR3 using miScript Target Protectors
Selected qRT-PCR Assays for microRNAs that regulate EGR3 (see all 145):
hsa-miR-132* hsa-miR-106a hsa-miR-128 hsa-miR-605 hsa-miR-508-5p hsa-miR-200b hsa-miR-130b hsa-miR-130a*
SwitchGear 3'UTR luciferase reporter plasmidEGR3 3' UTR sequence
Inhib. RNA
Products:
    
OriGene RNAi products in human, mouse, rat for EGR3
Predesigned siRNA for gene silencing in human, mouse, rat EGR3

Gene Editing
Products:
DNA2.0 Custom Protein Engineering Service for EGR3

Clone
Products:
     
OriGene clones in human, mouse for EGR3 (see all 6)
OriGene ORF clones in mouse, rat for EGR3
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
GenScript: all cDNA clones in your preferred vector (see all 3): EGR3 (NM_004430)
Browse Sino Biological Human cDNA Clones
DNA2.0 Custom Codon Optimized Gene Synthesis Service for EGR3
Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat EGR3

Cell Line
Products:
     
GenScript Custom overexpressing Cell Line Services for EGR3
Browse ESI BIO Cell Lines and PureStem Progenitors for EGR3 
In Situ Assay
Products:
   

 
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for EGR3


(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Subcellular locations from UniProtKB/Swiss-Prot
EGR3_HUMAN, Q06889: Nucleus (Probable)
Subcellular locations from COMPARTMENTS: 

CompartmentConfidence
nucleus4
cytoskeleton2
cytosol2
extracellular1

Gene Ontology (GO): 2 cellular component terms:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0005634nucleus IBA--
GO:0005737cytoplasm IBA--

Find genes that share ontologies with EGR3           About GenesLikeMe


(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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SuperPaths for EGR3 About    
See pathways by source

SuperPathContained pathways About
1Calcineurin-regulated NFAT-dependent transcription in lymphocytes
Calcineurin-regulated NFAT-dependent transcription in lymphocytes0.38
2Toll-like receptor signaling pathway
Hepatitis B0.31
3Viral carcinogenesis
Viral carcinogenesis
4Neuroscience
Neuroscience


Find genes that share SuperPaths with EGR3           About GenesLikeMe

Pathways by source                                                                                                                                                                 See SuperPaths
Show all pathways


1 Cell Signaling Technology (CST) Pathway for EGR3
    Neuroscience

1 BioSystems Pathway for EGR3
    Calcineurin-regulated NFAT-dependent transcription in lymphocytes


2 Kegg Pathways  (Kegg details for EGR3):
    Hepatitis B
Viral carcinogenesis

    Pathway & Disease-focused RT2 Profiler PCR Arrays including EGR3 (see all 9): 
          Stem Cell Transcription Factors in human mouse rat
          Leukemia in human mouse rat
          Prostate Cancer in human mouse rat
          Estrogen Receptor Signaling in human mouse rat
          Notch Signaling Targets in human mouse rat

Interactions:

    Search GeneGlobe Interaction Network for EGR3

STRING Interaction Network Preview (showing 5 interactants - click image to see 12)

Selected Interacting proteins for EGR3 (ENSP000003180574) via UniProtKB, MINT, STRING, and/or I2D (see all 12)
InteractantInteraction Details
GeneCardExternal ID(s)
FASLGENSP000003566944STRING: ENSP00000356694
IL2ENSP000002267304STRING: ENSP00000226730
NFATC1ENSP000003278504STRING: ENSP00000327850
NFATC2ENSP000003793304STRING: ENSP00000379330
NFATC3ENSP000003006594STRING: ENSP00000300659
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Gene Ontology (GO): Selected biological process terms (see all 13):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0001938positive regulation of endothelial cell proliferation IMP18059339
GO:0002042cell migration involved in sprouting angiogenesis IDA18059339
GO:0006351transcription, DNA-templated IEA--
GO:0007274neuromuscular synaptic transmission IEA--
GO:0007422peripheral nervous system development IEA--

Find genes that share ontologies with EGR3           About GenesLikeMe



(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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Browse Small Molecules at EMD Millipore
   Browse drugs & compounds from Enzo Life Sciences
  Browse compounds at ApexBio 

Browse Tocris compounds for EGR3

5 Novoseek inferred chemical compound relationships for EGR3 gene    About this table
Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
zinc 47.7 4 15837802 (1), 19154798 (1), 1906159 (1)
oligonucleotide 24 1 18059339 (1)
serine 16.5 1 15913882 (1)
cyclosporin a 8.35 2 9632757 (2)
estrogen 0.235 3 15171706 (2)



Find genes that share compounds with EGR3           About GenesLikeMe



(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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REFSEQ mRNAs for EGR3 gene (3 alternative transcripts): 
NM_001199880.1  NM_001199881.1  NM_004430.2  

Unigene Cluster for EGR3:

Early growth response 3
Hs.534313  [show with all ESTs]
Unigene Representative Sequence: NM_004430
5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
ENST00000317216(uc011kzn.1 uc011kzo.2 uc003xcm.1) ENST00000522910
ENST00000519492 ENST00000524088 ENST00000518773
miRNA
Products:
     
Block miRNA regulation of human, mouse, rat EGR3 using miScript Target Protectors
Selected qRT-PCR Assays for microRNAs that regulate EGR3 (see all 145):
hsa-miR-132* hsa-miR-106a hsa-miR-128 hsa-miR-605 hsa-miR-508-5p hsa-miR-200b hsa-miR-130b hsa-miR-130a*
SwitchGear 3'UTR luciferase reporter plasmidEGR3 3' UTR sequence
Inhib. RNA
Products:
     
OriGene RNAi products in human, mouse, rat for EGR3
Predesigned siRNA for gene silencing in human, mouse, rat EGR3
Clone
Products:
     
OriGene clones in human, mouse for EGR3 (see all 6)
OriGene ORF clones in mouse, rat for EGR3
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
GenScript: all cDNA clones in your preferred vector (see all 3): EGR3 (NM_004430)
DNA2.0 Custom Codon Optimized Gene Synthesis Service for EGR3
Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat EGR3
Primer
Products:
    
OriGene qPCR primer pairs and template standards for EGR3
OriGene qSTAR qPCR primer pairs in human, mouse for EGR3
Pre-validated RT2 qPCR Primer Assay in human, mouse, rat EGR3
  QuantiTect SYBR Green Assays in human, mouse, rat EGR3
  QuantiFast Probe-based Assays in human, mouse, rat EGR3

Additional mRNA sequence: 

AK292464.1 AK294968.1 AK295134.1 AK295834.1 AK313604.1 BC104765.1 BC112279.1 S40832.1 
X63741.1 

4 DOTS entries:

DT.211793  DT.101973857  DT.121466214  DT.121466198 

Selected AceView cDNA sequences (see all 50):

AA987624 CA443276 NM_004430 AI379641 BQ888150 CA392670 BE504464 AI912628 
BF477940 CA435467 AW615252 AW949526 S40832 CK002675 CA449499 BF438165 
AV645754 AI214530 BG741741 D57703 X63741 AI692740 AA916212 AI356714 

GeneLoc Exon Structure


(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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EGR3 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>2/3
CGAP TAG: ATAATTGAGT
EGR3 Expression
About this image


EGR3 expression in embryonic tissues and stem cells    About this table
Data from LifeMap, the Embryonic Development and Stem Cells Database
 selected tissues (see all 10) fully expand
 
 Ovary (Reproductive System)    fully expand to see all 2 entries
         Mature Granulosa Cells Antral Follicle
         Oviduct
 
 Thymus (Hematopoietic System)    fully expand to see all 2 entries
         T Helper Cells Thymus
 
 Blood (Cardiovascular System)    fully expand to see all 2 entries
         T Helper Cells Thymus
 
 Brain (Nervous System)    fully expand to see all 2 entries
         Cerebellum
 
 Bone (Muscoskeletal System)
         Bone Marrow
EGR3 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

EGR3 Protein Expression

SOURCE GeneReport for Unigene cluster: Hs.534313
    Pathway & Disease-focused RT2 Profiler PCR Arrays including EGR3 (see all 9): 
          Stem Cell Transcription Factors in human mouse rat
          Leukemia in human mouse rat
          Prostate Cancer in human mouse rat
          Estrogen Receptor Signaling in human mouse rat
          Notch Signaling Targets in human mouse rat

Primer
Products:
OriGene qPCR primer pairs and template standards for EGR3
OriGene qSTAR qPCR primer pairs in human, mouse for EGR3
Pre-validated RT2 qPCR Primer Assay in human, mouse, rat EGR3
QuantiTect SYBR Green Assays in human, mouse, rat EGR3
QuantiFast Probe-based Assays in human, mouse, rat EGR3
In Situ
Assay Products:
 

 
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for EGR3

(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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This gene was present in the common ancestor of animals and fungi.

Orthologs for EGR3 gene from Selected species (see all 12)    About this table
Organism Taxonomic
classification
Gene Description Human
Similarity
Orthology
Type
Details
mouse
(Mus musculus)
Mammalia Egr31 , 5 early growth response 31, 5 94.32(n)1
98.97(a)1
  14 (36.20 cM)5
136551  NM_018781.21  NP_061251.11 
 700774455 
tropical clawed frog
(Xenopus tropicalis)
Amphibia egr31 early growth response 3 68.01(n)
71.51(a)
  100488713  XM_002932703.2  XP_002932749.1 
zebrafish
(Danio rerio)
Actinopterygii egr31 early growth response 3 68.74(n)
70.13(a)
  436920  NM_001002647.1  NP_001002647.1 
fruit fly
(Drosophila melanogaster)
Insecta sr3 tracheal cell migration (sensu Insecta)
RNA polymerase more
82(a)     --
worm
(Caenorhabditis elegans)
Secernentea C27C12.23 Zinc finger, C2H2 type (3 domains) 80(a)
(best of 2)
  X(14881084-14882208)   --
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes RIM101(YHL027W)4 Transcriptional repressor involved in response to pH more   --   8(51111-52988) 856358  NP_011836.1 


ENSEMBL Gene Tree for EGR3 (if available)
TreeFam Gene Tree for EGR3 (if available)

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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Paralogs for EGR3 gene
EGR12  EGR42  WT12  EGR22  
3 SIMAP similar genes for EGR3 using alignment to 2 protein entries:     EGR3_HUMAN (see all proteins):
EGR1    EGR2    ZNF323

Find genes that share paralogs with EGR3           About GenesLikeMe



(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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Selected SNPs for EGR3 (see all 103)    About this table                                 

Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidClinical
significance
Chr 8 posSequence#AA
Chg
TypeMore#Allele
freq
PopTotal
sample
More
----------
rs1420325241,2
C--22544803(+) GTCTCC/TAGAGA 3 -- int10--------
rs1461504921,2
--22544830(+) GGAGAC/TCTCCT 3 -- int10--------
rs1401473681,2
--22544858(+) ACCCAC/TTGGAA 3 -- int10--------
rs1129577431,2
F--22544906(+) CCCTGA/GCTCCC 3 -- int13Minor allele frequency- G:0.05CSA WA 122
rs1421180261,2
--22544932(+) CTGTTC/GGCCTA 3 -- int10--------
rs1463386321,2
--22545044(+) ACAAAA/GTTCTG 3 -- int10--------
rs38336881,2
C--22545638(+) GTTGC-/TTTTTT 3 -- ut31 trp30--------
rs1864646411,2
--22545753(+) AACAAA/GGGAAA 3 -- ut310--------
rs1173028651,2
C,F--22545840(+) TCTAGC/TTTGGA 3 -- ut311Minor allele frequency- T:0.02NA 120
rs1891115131,2
--22546035(+) TCTTCA/GATATC 3 -- ut310--------

HapMap Linkage Disequilibrium report for EGR3 (22545172 - 22550815 bp)

Structural Variations
     Database of Genomic Variants (DGV) 6 variations for EGR3:    About this table    
Variant IDTypeSubtypePubMed ID
nsv6117CNV Insertion18451855
nsv890678CNV Loss21882294
nsv890677CNV Loss21882294
nsv8322CNV Gain18304495
essv21913CNV CNV17122850
essv19243CNV CNV17122850

Human Gene Mutation Database (HGMD): EGR3
Site Specific Mutation Identification with PCR Assays
SeqTarget long-range PCR primers for resequencing EGR3
DNA2.0 Custom Variant and Variant Library Synthesis for EGR3

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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OMIM gene information: 602419    OMIM disorders: --

5 diseases for EGR3:    
About MalaCards
chondromalacia    chondromalacia patellae    ancylostomiasis    bipolar i disorder
rheumatic fever

4 diseases from the University of Copenhagen DISEASES database for EGR3:
Rheumatic fever     Chondromalacia patellae     Schizophrenia     Ancylostomiasis

Find genes that share disorders with EGR3           About GenesLikeMe

1 Novoseek inferred disease relationship for EGR3 gene    About this table

Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
cancer 0 1 15171706 (1)

Genetic Association Database (GAD): EGR3
Human Genome Epidemiology (HuGE) Navigator: EGR3 (9 documents)

Export disorders for EGR3 gene to outside databases

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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PubMed articles for EGR3 gene, integrated from 10 sources (see all 58):
(articles sorted by number of sources associating them with EGR3)
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  1. EGR3, a novel member of the Egr family of genes encoding immediate- early transcription factors. (PubMed id 1906159)1, 2, 3, 9 Patwardhan S.... Sukhatme V.P. (Oncogene 1991)
  2. Association of calcineurin A gamma subunit (PPP3CC) and early growth response 3 (EGR3) gene polymorphisms with susceptibility to schizophrenia in a Japanese population. (PubMed id 20537399)1, 4 Kyogoku C....Kumagai S. (Psychiatry Res 2011)
  3. EGR3 as a potential susceptibility gene for schizophrenia in Korea. (PubMed id 20687139)1, 4 Kim S.H....Kim Y.S. (Am. J. Med. Genet. B Neuropsychiatr. Genet. 2010)
  4. Maternal genes and facial clefts in offspring: a comprehensive search for genetic associations in two population-based cleft studies from Scandinavia. (PubMed id 20634891)1, 4 Jugessur A....Murray J.C. (PLoS ONE 2010)
  5. No association between EGR gene family polymorphisms and schizophrenia in the Chinese population. (PubMed id 20144677)1, 4 Liu B.C....He G. (amp 2010)
  6. Association study of 21 circadian genes with bipolar I disorder, schizoaffective disorder, and schizophrenia. (PubMed id 19839995)1, 4 Mansour H.A....Nimgaonkar V.L. (Bipolar Disord 2009)
  7. High-density association study of 383 candidate genes for volumetric BMD at the femoral neck and lumbar spine among older men. (PubMed id 19453261)1, 4 Yerges L.M....Zmuda J.M. (J. Bone Miner. Res. 2009)
  8. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
  9. HIV Tat binds Egr proteins and enhances Egr-dependent transactivation of the Fas ligand promoter. (PubMed id 11909874)1, 3 Yang Y....Ashwell J.D. (J. Biol. Chem. 2002)
  10. Expression of PILOT, a putative transcription factor, requires two signals and is cyclosporin A sensitive in T cells. (PubMed id 8443122)1, 2 Mages H.W.... Kroczek R.A. (Int. Immunol. 1993)

(in PubMed, OMIM, and NCBI Bookshelf)
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 ANDOR
Aliases
Disorders
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  Query String
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OMIM
NCBI Bookshelf
  (Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 1960 HGNC: 3240 AceView: EGR3 Ensembl:ENSG00000179388 euGenes: HUgn1960
ECgene: EGR3 Kegg: 1960 H-InvDB: EGR3

(According to HUGE)
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  --

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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NameDescription
PharmGKB entry for EGR3 Pharmacogenomics, SNPs, Pathways
ATLAS Chromosomes in Cancer entry for EGR3 Genetics and Cytogenetics in Oncology and Haematology

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from LifeMap Sciences, Inc.)
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Patent Information for EGR3 gene:
Search GeneIP for patents involving EGR3

GeneCards and IP:
Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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