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Aliases for EGR3 Gene

Aliases for EGR3 Gene

  • Early Growth Response 3 2 3 5
  • Zinc Finger Protein Pilot 2 3 4
  • EGR-3 3 4
  • PILOT 3 4
  • Early Growth Response Protein 3 3

External Ids for EGR3 Gene

Previous GeneCards Identifiers for EGR3 Gene

  • GC08P022058
  • GC08M022898
  • GC08M022365
  • GC08M022567
  • GC08M022601
  • GC08M022545
  • GC08M021088

Summaries for EGR3 Gene

Entrez Gene Summary for EGR3 Gene

  • This gene encodes a transcriptional regulator that belongs to the EGR family of C2H2-type zinc-finger proteins. It is an immediate-early growth response gene which is induced by mitogenic stimulation. The protein encoded by this gene participates in the transcriptional regulation of genes in controling biological rhythm. It may also play a role in a wide variety of processes including muscle development, lymphocyte development, endothelial cell growth and migration, and neuronal development. Alternative splicing results in multiple transcript variants encoding distinct isoforms.[provided by RefSeq, Dec 2010]

GeneCards Summary for EGR3 Gene

EGR3 (Early Growth Response 3) is a Protein Coding gene. Diseases associated with EGR3 include Patella, Chondromalacia Of and Ancylostomiasis. Among its related pathways are Circadian rythm related genes and Toll-like Receptor Signaling Pathway. GO annotations related to this gene include transcription factor activity, sequence-specific DNA binding. An important paralog of this gene is EGR2.

UniProtKB/Swiss-Prot for EGR3 Gene

  • Probable transcription factor involved in muscle spindle development.

Gene Wiki entry for EGR3 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for EGR3 Gene

Genomics for EGR3 Gene

Regulatory Elements for EGR3 Gene

Enhancers for EGR3 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH08G023550 1.9 FANTOM5 Ensembl ENCODE dbSUPER 5.5 -859.8 -859751 5.7 ATF1 PKNOX1 SIN3A BRCA1 ZNF2 YY1 GATA2 ZNF143 FOS ZNF263 SLC25A37 ENTPD4 ENSG00000253390 EGR3 ENSG00000253200 TNFRSF10B GC08M023551
GH08G022998 1.8 FANTOM5 Ensembl ENCODE dbSUPER 5.1 -308.4 -308362 5.9 HDGF ATF1 ARID4B SIN3A YY1 GLIS2 SP3 YY2 NFYC REST RHOBTB2 EGR3 ENSG00000251034 PIR37908 PEBP4
GH08G023557 1.8 FANTOM5 Ensembl ENCODE dbSUPER 5 -866.8 -866791 4.8 ELF3 FOXA2 ZSCAN4 ZNF48 ZSCAN9 RAD21 RARA YY1 GATA2 FOS SLC25A37 ENSG00000253200 C8orf58 ENTPD4 LOC107986927 ENSG00000253390 NKX3-1 RNU4-71P EGR3 TNFRSF10C
GH08G022996 0.8 FANTOM5 dbSUPER 6.3 -303.4 -303443 0.3 ZSCAN4 ZNF248 RHOBTB2 EGR3 PEBP4
GH08G022700 2.1 FANTOM5 Ensembl ENCODE dbSUPER 1.9 -10.0 -9972 6.0 HDGF PKNOX1 FOXA2 MLX WRNIP1 ARID4B SIN3A YBX1 FEZF1 ZNF2 BIN3 XPO7 NPM2 TNFRSF10C PDLIM2 TNFRSF10B PPP3CC EGR3 GC08P022700 GC08M022705
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around EGR3 on UCSC Golden Path with GeneCards custom track

Promoters for EGR3 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000222102 2 1001 HDGF SIN3A ARID4B YBX1 FOS ZNF548 SP3 MXD4 TBX21 MIER3

Genomic Location for EGR3 Gene

Chromosome:
8
Start:
22,687,659 bp from pter
End:
22,693,302 bp from pter
Size:
5,644 bases
Orientation:
Minus strand

Genomic View for EGR3 Gene

Genes around EGR3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
EGR3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for EGR3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for EGR3 Gene

Proteins for EGR3 Gene

  • Protein details for EGR3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q06889-EGR3_HUMAN
    Recommended name:
    Early growth response protein 3
    Protein Accession:
    Q06889
    Secondary Accessions:
    • A8K8U9
    • B4DHJ5
    • E7EW38
    • Q2M3W2

    Protein attributes for EGR3 Gene

    Size:
    387 amino acids
    Molecular mass:
    42613 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for EGR3 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for EGR3 Gene

Post-translational modifications for EGR3 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for EGR3 Gene

No data available for DME Specific Peptides for EGR3 Gene

Domains & Families for EGR3 Gene

Gene Families for EGR3 Gene

Protein Domains for EGR3 Gene

Graphical View of Domain Structure for InterPro Entry

Q06889

UniProtKB/Swiss-Prot:

EGR3_HUMAN :
  • Belongs to the EGR C2H2-type zinc-finger protein family.
Family:
  • Belongs to the EGR C2H2-type zinc-finger protein family.
genes like me logo Genes that share domains with EGR3: view

Function for EGR3 Gene

Molecular function for EGR3 Gene

GENATLAS Biochemistry:
immediate early growth response,gene 3,homologous to EGR1,EGR2
UniProtKB/Swiss-Prot Function:
Probable transcription factor involved in muscle spindle development.

Gene Ontology (GO) - Molecular Function for EGR3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003676 nucleic acid binding IEA --
GO:0003677 DNA binding IEA --
GO:0003700 transcription factor activity, sequence-specific DNA binding TAS 1906159
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with EGR3: view
genes like me logo Genes that share phenotypes with EGR3: view

Animal Models for EGR3 Gene

MGI Knock Outs for EGR3:

Animal Model Products

CRISPR Products

Transcription Factor Targets for EGR3 Gene

Selected GeneGlobe predicted Target genes for EGR3

Inhibitory RNA Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology and HOMER Transcription for EGR3 Gene

Localization for EGR3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for EGR3 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for EGR3 gene
Compartment Confidence
nucleus 5
cytosol 3
cytoskeleton 2
extracellular 1

Gene Ontology (GO) - Cellular Components for EGR3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with EGR3: view

Pathways & Interactions for EGR3 Gene

genes like me logo Genes that share pathways with EGR3: view

Pathways by source for EGR3 Gene

1 Cell Signaling Technology pathway for EGR3 Gene
2 KEGG pathways for EGR3 Gene

Gene Ontology (GO) - Biological Process for EGR3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001938 positive regulation of endothelial cell proliferation IMP 18059339
GO:0002042 cell migration involved in sprouting angiogenesis IDA 18059339
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0007274 neuromuscular synaptic transmission IEA --
genes like me logo Genes that share ontologies with EGR3: view

No data available for SIGNOR curated interactions for EGR3 Gene

Drugs & Compounds for EGR3 Gene

(4) Drugs for EGR3 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(1) Additional Compounds for EGR3 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with EGR3: view

Transcripts for EGR3 Gene

Unigene Clusters for EGR3 Gene

Early growth response 3:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for EGR3 Gene

No ASD Table

Relevant External Links for EGR3 Gene

GeneLoc Exon Structure for
EGR3
ECgene alternative splicing isoforms for
EGR3

Expression for EGR3 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for EGR3 Gene

mRNA differential expression in normal tissues according to GTEx for EGR3 Gene

This gene is overexpressed in Skin - Not Sun Exposed (Suprapubic) (x4.2) and Skin - Sun Exposed (Lower leg) (x4.0).

NURSA nuclear receptor signaling pathways regulating expression of EGR3 Gene:

EGR3

SOURCE GeneReport for Unigene cluster for EGR3 Gene:

Hs.534313

Evidence on tissue expression from TISSUES for EGR3 Gene

  • Nervous system(4.8)
  • Blood(4.3)
genes like me logo Genes that share expression patterns with EGR3: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for EGR3 Gene

Orthologs for EGR3 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for EGR3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia EGR3 34 35
  • 100 (n)
dog
(Canis familiaris)
Mammalia EGR3 34 35
  • 96.3 (n)
cow
(Bos Taurus)
Mammalia EGR3 34 35
  • 95 (n)
mouse
(Mus musculus)
Mammalia Egr3 34 16 35
  • 94.32 (n)
rat
(Rattus norvegicus)
Mammalia Egr3 34
  • 93.97 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia EGR3 35
  • 91 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia EGR3 35
  • 86 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia egr3 34
  • 68.01 (n)
zebrafish
(Danio rerio)
Actinopterygii egr3 34 35
  • 68.74 (n)
fruit fly
(Drosophila melanogaster)
Insecta sr 36 35
  • 82 (a)
worm
(Caenorhabditis elegans)
Secernentea C27C12.2 36
  • 80 (a)
Y55F3AM.7 36
  • 72 (a)
ZC328.2 35
  • 18 (a)
ManyToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes MIG2 35
  • 12 (a)
ManyToMany
MIG3 35
  • 11 (a)
ManyToMany
RIM101 37
Species where no ortholog for EGR3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for EGR3 Gene

ENSEMBL:
Gene Tree for EGR3 (if available)
TreeFam:
Gene Tree for EGR3 (if available)

Paralogs for EGR3 Gene

Paralogs for EGR3 Gene

(3) SIMAP similar genes for EGR3 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with EGR3: view

Variants for EGR3 Gene

Sequence variations from dbSNP and Humsavar for EGR3 Gene

SNP ID Clin Chr 08 pos Sequence Context AA Info Type
rs1000336113 -- 22,690,439(+) GCACT(A/G)GAGGG utr-variant-3-prime
rs1000451981 -- 22,690,289(+) CTGGC(C/T)CCTGA utr-variant-3-prime
rs1000672938 -- 22,692,112(+) CTAGG(C/G)AGGGT intron-variant, utr-variant-5-prime
rs1000787092 -- 22,691,910(+) CGCCG(C/T)GCCTT intron-variant, reference, missense
rs1000846963 -- 22,695,009(+) GGGCT(A/G)GGGAC upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for EGR3 Gene

Variant ID Type Subtype PubMed ID
esv2759604 CNV loss 17122850
nsv1112959 CNV deletion 24896259
nsv6117 CNV insertion 18451855
nsv8322 CNV gain 18304495

Variation tolerance for EGR3 Gene

Residual Variation Intolerance Score: 24.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.38; 8.40% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for EGR3 Gene

Human Gene Mutation Database (HGMD)
EGR3
SNPedia medical, phenotypic, and genealogical associations of SNPs for
EGR3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for EGR3 Gene

Disorders for EGR3 Gene

MalaCards: The human disease database

(5) MalaCards diseases for EGR3 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
patella, chondromalacia of
  • chondromalacia patellae
ancylostomiasis
  • ancylostoma duodenale infection
bipolar i disorder
plexopathy
schizophrenia
  • schizophrenia 12
- elite association - COSMIC cancer census association via MalaCards
Search EGR3 in MalaCards View complete list of genes associated with diseases

Relevant External Links for EGR3

Genetic Association Database (GAD)
EGR3
Human Genome Epidemiology (HuGE) Navigator
EGR3
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
EGR3
genes like me logo Genes that share disorders with EGR3: view

No data available for UniProtKB/Swiss-Prot and Genatlas for EGR3 Gene

Publications for EGR3 Gene

  1. EGR3, a novel member of the Egr family of genes encoding immediate- early transcription factors. (PMID: 1906159) Patwardhan S. … Sukhatme V.P. (Oncogene 1991) 2 3 4 22 64
  2. Association of calcineurin A gamma subunit (PPP3CC) and early growth response 3 (EGR3) gene polymorphisms with susceptibility to schizophrenia in a Japanese population. (PMID: 20537399) Kyogoku C. … Kumagai S. (Psychiatry Res 2011) 3 46 64
  3. Maternal genes and facial clefts in offspring: a comprehensive search for genetic associations in two population-based cleft studies from Scandinavia. (PMID: 20634891) Jugessur A. … Murray J.C. (PLoS ONE 2010) 3 46 64
  4. Vascular endothelial growth factor activation of endothelial cells is mediated by early growth response-3. (PMID: 19965691) Suehiro J. … Minami T. (Blood 2010) 3 22 64
  5. No association between EGR gene family polymorphisms and schizophrenia in the Chinese population. (PMID: 20144677) Liu B.C. … He G. (Prog. Neuropsychopharmacol. Biol. Psychiatry 2010) 3 46 64

Products for EGR3 Gene

Sources for EGR3 Gene

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