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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

EGR3 Gene

protein-coding   GIFtS: 61
GCID: GC08M022545

Early Growth Response 3

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Early Growth Response 31 2
Zinc Finger Protein Pilot1 2 3
EGR-32 3
PILOT2 3
Early Growth Response Protein 32

External Ids:    HGNC: 32401   Entrez Gene: 19602   Ensembl: ENSG000001793887   OMIM: 6024195   UniProtKB: Q068893   

Export aliases for EGR3 gene to outside databases

Previous GC identifers: GC08P022058 GC08M022898 GC08M022365 GC08M022567 GC08M022601 GC08M021088


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for EGR3 Gene:
This gene encodes a transcriptional regulator that belongs to the EGR family of C2H2-type zinc-finger proteins. It
is an immediate-early growth response gene which is induced by mitogenic stimulation. The protein encoded by this
gene participates in the transcriptional regulation of genes in controling biological rhythm. It may also play a
role in a wide variety of processes including muscle development, lymphocyte development, endothelial cell growth
and migration, and neuronal development. Alternative splicing results in multiple transcript variants encoding
distinct isoforms.(provided by RefSeq, Dec 2010)

GeneCards Summary for EGR3 Gene: 
EGR3 (early growth response 3) is a protein-coding gene. Diseases associated with EGR3 include bipolar i disorder, and chondromalacia patellae, and among its related super-pathways are Calcium signaling in the CD4+ TCR pathway and Toll-like receptor signaling pathway. GO annotations related to this gene include DNA binding and sequence-specific DNA binding transcription factor activity. An important paralog of this gene is EGR1.

UniProtKB/Swiss-Prot: EGR3_HUMAN, Q06889
Function: Probable transcription factor involved in muscle spindle development

Gene Wiki entry for EGR3 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000008.10  NT_167187.1  NC_018919.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the EGR3 gene promoter:
         Nkx3-1 v2   Nkx3-1   PPAR-alpha   AREB6   HSF2   Nkx3-1 v1   c-Ets-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidEGR3 promoter sequence
   Search SABiosciences Chromatin IP Primers for EGR3

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat EGR3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 8p23-p21   Ensembl cytogenetic band:  8p21.3   HGNC cytogenetic band: 8p23-p21

EGR3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
EGR3 gene location

GeneLoc information about chromosome 8         GeneLoc Exon Structure

GeneLoc location for GC08M022545:  view genomic region     (about GC identifiers)

Start:
22,545,172 bp from pter      End:
22,550,815 bp from pter
Size:
5,644 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: EGR3_HUMAN, Q06889 (See protein sequence)
Recommended Name: Early growth response protein 3  
Size: 387 amino acids; 42613 Da
Subcellular location: Nucleus (Probable)
Developmental stage: In T-cells, expressed 20 minutes following activation
Secondary accessions: A8K8U9 B4DHJ5 E7EW38 Q2M3W2
Alternative splicing: 2 isoforms:  Q06889-1   Q06889-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for EGR3: NX_Q06889

Explore proteomics data for EGR3 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q06889

  • EGR3 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    EGR3 Protein Expression
    REFSEQ proteins (3 alternative transcripts): 
    NP_001186809.1  NP_001186810.1  NP_004421.2  

    ENSEMBL proteins: 
     ENSP00000318057   ENSP00000430310   ENSP00000429370  

    Human Recombinant Protein Products for EGR3: 
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    Novus Biologicals EGR3 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for EGR3 

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IBA--
    GO:0005737cytoplasm IBA--

    EGR3 for ontologies           About GeneDecksing



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    Cloud-Clone Corp. CLIAs for EGR3


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    ZNF: Zinc fingers, C2H2-type

    4 InterPro protein domains:
     IPR015880 Znf_C2H2-like
     IPR013087 Znf_C2H2/integrase_DNA-bd
     IPR007087 Znf_C2H2
     IPR021849 DUF3446

    Graphical View of Domain Structure for InterPro Entry Q06889

    ProtoNet protein and cluster: Q06889

    1 Blocks protein domain: IPB007086 C2H2-type zinc finger signature

    UniProtKB/Swiss-Prot: EGR3_HUMAN, Q06889
    Similarity: Belongs to the EGR C2H2-type zinc-finger protein family
    Similarity: Contains 3 C2H2-type zinc fingers


    EGR3 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: EGR3_HUMAN, Q06889
    Function: Probable transcription factor involved in muscle spindle development

         Genatlas biochemistry entry for EGR3:
    immediate early growth response,gene 3,homologous to EGR1,EGR2

         Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003677DNA binding IEA--
    GO:0003700sequence-specific DNA binding transcription factor activity TAS1906159
    GO:0008270zinc ion binding ----
    GO:0046872metal ion binding IEA--
         
    EGR3 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for EGR3:
     Synthetic lethal with imatinib 

         7 MGI mutant phenotypes (inferred from 4 alleles(MGI details for Egr3):
     behavior/neurological  mortality/aging  muscle  nervous system  no phenotypic analysis 
     skeleton  vision/eye 

    EGR3 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Egr3tm1Jmi for EGR3

       inGenious Targeting Laboratory - Custom generated mouse model solutions for EGR3 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for EGR3

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for EGR3 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for EGR3 

    miRNA
    Products:
        
    miRTarBase miRNAs that target EGR3:
    hsa-let-7a (MIRT004963)

    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat EGR3
    8/145 QIAGEN miScript miRNA Assays for microRNAs that regulate EGR3 (see all 145):
    hsa-miR-132* hsa-miR-106a hsa-miR-128 hsa-miR-605 hsa-miR-508-5p hsa-miR-200b hsa-miR-130b hsa-miR-130a*
    SwitchGear 3'UTR luciferase reporter plasmidEGR3 3' UTR sequence
    Inhib. RNA
    Products:
        
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    Gene Editing
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for EGR3


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for EGR3 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Calcium signaling in the CD4+ TCR pathway
    Calcineurin-regulated NFAT-dependent transcription in lymphocytes0.38
    2Toll-like receptor signaling pathway
    Hepatitis B0.31
    3Viral carcinogenesis
    Viral carcinogenesis
    4Neuroscience
    Neuroscience

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 Cell Signaling Technology (CST) Pathway for EGR3
        Neuroscience

    1 BioSystems Pathway for EGR3
        Calcineurin-regulated NFAT-dependent transcription in lymphocytes


    2         Kegg Pathways  (Kegg details for EGR3):
        Hepatitis B
    Viral carcinogenesis


    EGR3 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for EGR3

    STRING Interaction Network Preview (showing 5 interactants - click image to see more details)

    5 Interacting proteins for EGR3 (ENSP000003180574) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    FASLGENSP000003566944STRING: ENSP00000356694
    IL2ENSP000002267304STRING: ENSP00000226730
    NFATC1ENSP000003278504STRING: ENSP00000327850
    NFATC2ENSP000003793304STRING: ENSP00000379330
    NFATC3ENSP000003006594STRING: ENSP00000300659
    About this table

    Gene Ontology (GO): 5/13 biological process terms (GO ID links to tree view) (see all 13):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001938positive regulation of endothelial cell proliferation IMP18059339
    GO:0002042cell migration involved in sprouting angiogenesis IDA18059339
    GO:0006351transcription, DNA-dependent IEA--
    GO:0007274neuromuscular synaptic transmission IEA--
    GO:0007422peripheral nervous system development IEA--

    EGR3 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    EGR3 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for EGR3

    5 Novoseek inferred chemical compound relationships for EGR3 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    zinc 47.7 4 15837802 (1), 19154798 (1), 1906159 (1)
    oligonucleotide 24 1 18059339 (1)
    serine 16.5 1 15913882 (1)
    cyclosporin a 8.35 2 9632757 (2)
    estrogen 0.235 3 15171706 (2)

    Search CenterWatch for drugs/clinical trials and news about EGR3

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for EGR3 gene (3 alternative transcripts): 
    NM_001199880.1  NM_001199881.1  NM_004430.2  

    Unigene Cluster for EGR3:

    Early growth response 3
    Hs.534313  [show with all ESTs]
    Unigene Representative Sequence: NM_004430
    5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000317216(uc011kzn.1 uc011kzo.2 uc003xcm.1) ENST00000522910
    ENST00000519492 ENST00000524088 ENST00000518773
    miRNA
    Products:
         
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat EGR3
    8/145 QIAGEN miScript miRNA Assays for microRNAs that regulate EGR3 (see all 145):
    hsa-miR-132* hsa-miR-106a hsa-miR-128 hsa-miR-605 hsa-miR-508-5p hsa-miR-200b hsa-miR-130b hsa-miR-130a*
    SwitchGear 3'UTR luciferase reporter plasmidEGR3 3' UTR sequence
    Inhib. RNA
    Products:
         
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    DNA2.0 Custom Codon Optimized Gene Synthesis Service for EGR3
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat EGR3
    Sirion Biotech Customized lentivirus for stable overexpression of EGR3 
                         Customized lentivirus expression plasmids for stable overexpression of EGR3 
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat EGR3
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat EGR3

    Additional mRNA sequence: 

    AK292464.1 AK294968.1 AK295134.1 AK295834.1 AK313604.1 BC104765.1 BC112279.1 S40832.1 
    X63741.1 

    4 DOTS entries:

    DT.211793  DT.101973857  DT.121466214  DT.121466198 

    24/50 AceView cDNA sequences (see all 50):

    NM_004430 AA987624 CA443276 BE504464 CA392670 AI379641 BQ888150 AI214530 
    D57703 BF110306 AI911960 BG741741 AI356714 CA449499 BG743653 AV645754 
    AI912628 AI692740 AA916212 AW615252 AA971502 X63741 AI697529 AW949526 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    EGR3 expression in normal human tissues (normalized intensities)      EGR3 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: ATAATTGAGT
    EGR3 Expression
    About this image


    EGR3 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/8 selected tissues (see all 8) fully expand
     
     Thymus (Hematopoietic System)    fully expand to see all 2 entries
             T Helper Cells Thymus
     
     Tooth (Integumentary System)    fully expand to see all 2 entries
             visceral organ/oral region/upper jaw   
     
     Blood (Cardiovascular System)    fully expand to see all 2 entries
             T Helper Cells Thymus
     
     Somite (Muscoskeletal System)
             Muscle Progenitor Cells Thoracic Ventrolateral Dermomyotome Lip
     
     Ovary (Reproductive System)
             Mature Granulosa Cells Antral Follicle

    See EGR3 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for EGR3

    SOURCE GeneReport for Unigene cluster: Hs.534313
        SABiosciences Expression via Pathway-Focused PCR Arrays including EGR3 (see all 9): 
              Stem Cell Transcription Factors in human mouse rat
              Leukemia in human mouse rat
              Prostate Cancer in human mouse rat
              Estrogen Receptor Signaling in human mouse rat
              Notch Signaling Targets in human mouse rat

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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for EGR3

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for EGR3 gene from 4/11 species (see all 11)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Egr31 , 5 early growth response 31, 5 94.32(n)1
    98.97(a)1
      14 (36.20 cM)5
    136551  NM_018781.21  NP_061251.11 
     700774455 
    zebrafish
    (Danio rerio)
    Actinopterygii zgc:920201 zgc:92020 68.57(n)
    70.13(a)
      436920  NM_001002647.1  NP_001002647.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta sr3 tracheal cell migration (sensu Insecta)
    RNA polymerase more
    82(a)     --
    worm
    (Caenorhabditis elegans)
    Secernentea C27C12.23 Zinc finger, C2H2 type (3 domains) 80(a)
    (best of 2)
      X(14881084-14882208)   --


    ENSEMBL Gene Tree for EGR3 (if available)
    TreeFam Gene Tree for EGR3 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for EGR3 gene
    EGR12  EGR42  WT12  EGR22  
    3 SIMAP similar genes for EGR3 using alignment to 2 protein entries:     EGR3_HUMAN (see all proteins):
    EGR1    EGR2    ZNF323

    EGR3 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/103 SNPs in EGR3 are shown (see all 103)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 8 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1420325241,2
    C--22544803(+) GTCTCC/TAGAGA 3 -- int10--------
    rs1461504921,2
    --22544830(+) GGAGAC/TCTCCT 3 -- int10--------
    rs1401473681,2
    --22544858(+) ACCCAC/TTGGAA 3 -- int10--------
    rs1129577431,2
    F--22544906(+) CCCTGA/GCTCCC 3 -- int13Minor allele frequency- G:0.05CSA WA 122
    rs1421180261,2
    --22544932(+) CTGTTC/GGCCTA 3 -- int10--------
    rs1463386321,2
    --22545044(+) ACAAAA/GTTCTG 3 -- int10--------
    rs38336881,2
    C--22545638(+) GTTGC-/TTTTTT 3 -- ut31 trp30--------
    rs1864646411,2
    --22545753(+) AACAAA/GGGAAA 3 -- ut310--------
    rs1173028651,2
    C,F--22545840(+) TCTAGC/TTTGGA 3 -- ut311Minor allele frequency- T:0.02NA 120
    rs1891115131,2
    --22546035(+) TCTTCA/GATATC 3 -- ut310--------

    HapMap Linkage Disequilibrium report for EGR3 (22545172 - 22550815 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 6 variations for EGR3:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv6117CNV Insertion18451855
    nsv890678CNV Loss21882294
    nsv890677CNV Loss21882294
    nsv8322CNV Gain18304495
    essv21913CNV CNV17122850
    essv19243CNV CNV17122850


    Human Gene Mutation Database (HGMD): EGR3
    SABiosciences Cancer Mutation PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 602419    OMIM disorders: --

    17 diseases for EGR3:    About MalaCards
    bipolar i disorder    chondromalacia patellae    chondromalacia    ancylostomiasis
    rheumatic fever    schizoaffective disorder    endotheliitis    hepatitis b
    schizophrenia    ischemia    ataxia    hepatitis
    neuronitis    breast cancer    prostate cancer    leukemia
    prostatitis

    4 diseases from the University of Copenhagen DISEASES database for EGR3:
    Rheumatic fever     Chondromalacia patellae     Schizophrenia     Ancylostomiasis

    EGR3 for disorders           About GeneDecksing

    1 Novoseek inferred disease relationship for EGR3 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    cancer 0 1 15171706 (1)

    Genetic Association Database (GAD): EGR3
    Human Genome Epidemiology (HuGE) Navigator: EGR3 (9 documents)

    Export disorders for EGR3 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for EGR3 gene, integrated from 9 sources (see all 56):
    (articles sorted by number of sources associating them with EGR3)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. EGR3, a novel member of the Egr family of genes encoding immediate- early transcription factors. (PubMed id 1906159)1, 2, 3, 9 Patwardhan S.... Sukhatme V.P. (1991)
    2. EGR3 as a potential susceptibility gene for schizophr enia in Korea. (PubMed id 20687139)1, 4 Kim S.H....Kim Y.S. (2010)
    3. Maternal genes and facial clefts in offspring: a comp rehensive search for genetic associations in two population-based cleft studies from Scandinavia. (PubMed id 20634891)1, 4 Jugessur A....Murray J.C. (2010)
    4. No association between EGR gene family polymorphisms and schizophrenia in the Chinese population. (PubMed id 20144677)1, 4 Liu B.C....He G. (2010)
    5. Association of calcineurin A gamma subunit (PPP3CC) a nd early growth response 3 (EGR3) gene polymorphisms with susceptibility to sch izophrenia in a Japanese population. (PubMed id 20537399)1, 4 Kyogoku C....Kumagai S. (2010)
    6. Association study of 21 circadian genes with bipolar I disorder, schizoaffective disorder, and schizophrenia. (PubMed id 19839995)1, 4 Mansour H.A....Nimgaonkar V.L. (2009)
    7. High-density association study of 383 candidate genes for volumetric BMD at the femoral neck and lumbar spine among older men. (PubMed id 19453261)1, 4 Yerges L.M....Zmuda J.M. (2009)
    8. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    9. HIV Tat binds Egr proteins and enhances Egr-dependent transactivation of the Fas ligand promoter. (PubMed id 11909874)1, 3 Yang Y....Ashwell J.D. (2002)
    10. Expression of PILOT, a putative transcription factor, requires two signals and is cyclosporin A sensitive in T cells. (PubMed id 8443122)1, 2 Mages H.W.... Kroczek R.A. (1993)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 1960 HGNC: 3240 AceView: EGR3 Ensembl:ENSG00000179388 euGenes: HUgn1960
    ECgene: EGR3 Kegg: 1960 H-InvDB: EGR3

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for EGR3 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for EGR3 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for EGR3 gene:
    Search GeneIP for patents involving EGR3

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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