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Aliases for EGR3 Gene

Aliases for EGR3 Gene

  • Early Growth Response 3 2 3 5
  • Zinc Finger Protein Pilot 2 3 4
  • EGR-3 3 4
  • PILOT 3 4

External Ids for EGR3 Gene

Previous GeneCards Identifiers for EGR3 Gene

  • GC08P022058
  • GC08M022898
  • GC08M022365
  • GC08M022567
  • GC08M022601
  • GC08M022545
  • GC08M021088

Summaries for EGR3 Gene

Entrez Gene Summary for EGR3 Gene

  • This gene encodes a transcriptional regulator that belongs to the EGR family of C2H2-type zinc-finger proteins. It is an immediate-early growth response gene which is induced by mitogenic stimulation. The protein encoded by this gene participates in the transcriptional regulation of genes in controling biological rhythm. It may also play a role in a wide variety of processes including muscle development, lymphocyte development, endothelial cell growth and migration, and neuronal development. Alternative splicing results in multiple transcript variants encoding distinct isoforms.[provided by RefSeq, Dec 2010]

GeneCards Summary for EGR3 Gene

EGR3 (Early Growth Response 3) is a Protein Coding gene. Diseases associated with EGR3 include Chondromalacia Patellae and Ancylostomiasis. Among its related pathways are Calcineurin-regulated NFAT-dependent transcription in lymphocytes and Viral carcinogenesis. GO annotations related to this gene include transcription factor activity, sequence-specific DNA binding. An important paralog of this gene is EGR1.

UniProtKB/Swiss-Prot for EGR3 Gene

  • Probable transcription factor involved in muscle spindle development.

Gene Wiki entry for EGR3 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for EGR3 Gene

Genomics for EGR3 Gene

Regulatory Elements for EGR3 Gene

Enhancers for EGR3 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around EGR3 on UCSC Golden Path with GeneCards custom track

Promoters for EGR3 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around EGR3 on UCSC Golden Path with GeneCards custom track

Genomic Location for EGR3 Gene

22,687,659 bp from pter
22,693,302 bp from pter
5,644 bases
Minus strand

Genomic View for EGR3 Gene

Genes around EGR3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
EGR3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for EGR3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for EGR3 Gene

Proteins for EGR3 Gene

  • Protein details for EGR3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Early growth response protein 3
    Protein Accession:
    Secondary Accessions:
    • A8K8U9
    • B4DHJ5
    • E7EW38
    • Q2M3W2

    Protein attributes for EGR3 Gene

    387 amino acids
    Molecular mass:
    42613 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for EGR3 Gene


neXtProt entry for EGR3 Gene

Proteomics data for EGR3 Gene at MOPED

Post-translational modifications for EGR3 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for EGR3 Gene

No data available for DME Specific Peptides for EGR3 Gene

Domains & Families for EGR3 Gene

Gene Families for EGR3 Gene

Protein Domains for EGR3 Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the EGR C2H2-type zinc-finger protein family.
  • Contains 3 C2H2-type zinc fingers.
  • Belongs to the EGR C2H2-type zinc-finger protein family.
  • Contains 3 C2H2-type zinc fingers.
genes like me logo Genes that share domains with EGR3: view

Function for EGR3 Gene

Molecular function for EGR3 Gene

GENATLAS Biochemistry:
immediate early growth response,gene 3,homologous to EGR1,EGR2
UniProtKB/Swiss-Prot Function:
Probable transcription factor involved in muscle spindle development.
genes like me logo Genes that share phenotypes with EGR3: view

Animal Models for EGR3 Gene

MGI Knock Outs for EGR3:

Animal Model Products

Transcription Factor Targets for EGR3 Gene

Selected GeneGlobe predicted Target genes for EGR3

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology and HOMER Transcription for EGR3 Gene

Localization for EGR3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for EGR3 Gene

Subcellular locations from

Jensen Localization Image for EGR3 Gene COMPARTMENTS Subcellular localization image for EGR3 gene
Compartment Confidence
nucleus 5
cytosol 3
cytoskeleton 1
extracellular 1

No data available for Gene Ontology (GO) - Cellular Components for EGR3 Gene

Pathways & Interactions for EGR3 Gene

genes like me logo Genes that share pathways with EGR3: view

Pathways by source for EGR3 Gene

1 Cell Signaling Technology pathway for EGR3 Gene
2 KEGG pathways for EGR3 Gene

Interacting Proteins for EGR3 Gene

Gene Ontology (GO) - Biological Process for EGR3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001938 positive regulation of endothelial cell proliferation IMP 18059339
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0007274 neuromuscular synaptic transmission IEA --
GO:0007517 muscle organ development TAS 9731539
GO:0007623 circadian rhythm TAS 9488654
genes like me logo Genes that share ontologies with EGR3: view

No data available for SIGNOR curated interactions for EGR3 Gene

Drugs & Compounds for EGR3 Gene

(4) Drugs for EGR3 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(1) Additional Compounds for EGR3 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with EGR3: view

Transcripts for EGR3 Gene

Unigene Clusters for EGR3 Gene

Early growth response 3:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for EGR3 Gene

No ASD Table

Relevant External Links for EGR3 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for EGR3 Gene

mRNA expression in normal human tissues for EGR3 Gene

mRNA differential expression in normal tissues according to GTEx for EGR3 Gene

This gene is overexpressed in Skin - Not Sun Exposed (Suprapubic) (x4.2) and Skin - Sun Exposed (Lower leg) (x4.0).

SOURCE GeneReport for Unigene cluster for EGR3 Gene Hs.534313

genes like me logo Genes that share expression patterns with EGR3: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for EGR3 Gene

Orthologs for EGR3 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for EGR3 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia EGR3 35
  • 95 (n)
  • 98.97 (a)
EGR3 36
  • 99 (a)
(Canis familiaris)
Mammalia EGR3 35
  • 96.3 (n)
  • 99.48 (a)
EGR3 36
  • 99 (a)
(Mus musculus)
Mammalia Egr3 35
  • 94.32 (n)
  • 98.97 (a)
Egr3 16
Egr3 36
  • 99 (a)
(Pan troglodytes)
Mammalia EGR3 35
  • 100 (n)
  • 100 (a)
EGR3 36
  • 100 (a)
(Rattus norvegicus)
Mammalia Egr3 35
  • 93.97 (n)
  • 98.71 (a)
(Monodelphis domestica)
Mammalia EGR3 36
  • 86 (a)
(Ornithorhynchus anatinus)
Mammalia EGR3 36
  • 91 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia egr3 35
  • 68.01 (n)
  • 71.51 (a)
(Danio rerio)
Actinopterygii egr3 35
  • 68.74 (n)
  • 70.13 (a)
egr3 36
  • 64 (a)
fruit fly
(Drosophila melanogaster)
Insecta sr 37
  • 82 (a)
sr 36
  • 12 (a)
(Caenorhabditis elegans)
Secernentea C27C12.2 37
  • 80 (a)
Y55F3AM.7 37
  • 72 (a)
ZC328.2 36
  • 18 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes MIG2 36
  • 12 (a)
MIG3 36
  • 11 (a)
RIM101 38
Species with no ortholog for EGR3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for EGR3 Gene

Gene Tree for EGR3 (if available)
Gene Tree for EGR3 (if available)

Paralogs for EGR3 Gene

Paralogs for EGR3 Gene

(3) SIMAP similar genes for EGR3 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with EGR3: view

Variants for EGR3 Gene

Sequence variations from dbSNP and Humsavar for EGR3 Gene

SNP ID Clin Chr 08 pos Sequence Context AA Info Type
rs3750191 -- 22,688,556(+) TAGTA(G/T)TATTT utr-variant-3-prime
rs3750192 -- 22,691,277(+) GTGCT(G/T)AGCGC reference, synonymous-codon
rs11136094 -- 22,689,539(+) GGCAG(A/G)GGGCA utr-variant-3-prime
rs6988888 -- 22,691,594(+) GCGTA(G/T)CGCAT intron-variant
rs1049155 -- 22,688,472(-) AGAAG(G/T)AGAGA utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for EGR3 Gene

Variant ID Type Subtype PubMed ID
essv19243 CNV CNV 17122850
essv21913 CNV CNV 17122850
nsv6117 CNV Insertion 18451855
nsv890677 CNV Loss 21882294
nsv8322 CNV Gain 18304495
nsv890678 CNV Loss 21882294

Variation tolerance for EGR3 Gene

Residual Variation Intolerance Score: 24.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.38; 8.40% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for EGR3 Gene

Human Gene Mutation Database (HGMD)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for EGR3 Gene

Disorders for EGR3 Gene

MalaCards: The human disease database

(4) MalaCards diseases for EGR3 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
chondromalacia patellae
  • chondromalacia of patella
  • ancylostomosis
bipolar i disorder
  • schizophrenia 12
- elite association - COSMIC cancer census association via MalaCards
Search EGR3 in MalaCards View complete list of genes associated with diseases

Relevant External Links for EGR3

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with EGR3: view

No data available for UniProtKB/Swiss-Prot and Genatlas for EGR3 Gene

Publications for EGR3 Gene

  1. EGR3, a novel member of the Egr family of genes encoding immediate- early transcription factors. (PMID: 1906159) Patwardhan S. … Sukhatme V.P. (Oncogene 1991) 2 3 4 23 67
  2. Vascular endothelial growth factor activation of endothelial cells is mediated by early growth response-3. (PMID: 19965691) Suehiro J. … Minami T. (Blood 2010) 3 23
  3. The zinc-finger transcription factor, early growth response 3, mediates VEGF-induced angiogenesis. (PMID: 18059339) Liu D. … Zachary I. (Oncogene 2008) 3 23
  4. Transcription factor EGR3 is involved in the estrogen-signaling pathway in breast cancer cells. (PMID: 15171706) Inoue A. … Hayashi S.I. (J. Mol. Endocrinol. 2004) 3 23
  5. Vascular endothelial growth factor-regulated gene expression in endothelial cells: KDR-mediated induction of Egr3 and the related nuclear receptors Nur77, Nurr1, and Nor1. (PMID: 14525795) Liu D. … Zachary I. (Arterioscler. Thromb. Vasc. Biol. 2003) 3 23

Products for EGR3 Gene

Sources for EGR3 Gene