Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 



EGR2 Gene

protein-coding   GIFtS: 72
GCID: GC10M064571

Early Growth Response 2

(Previous names: early growth response 2 (Krox-20 homolog, Drosophila))
(Previous symbol: KROX20)
  See EGR2-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

TryGeneCards Plus

This gene clusters with an RNA gene
Subcategory (RNA class): lncRNA

Quality score for the ORGUL clustered with this gene is 3

Aliases
Early Growth Response 21 2     Krox-20 Homolog1
KROX201 2 3 5     CMT1D2
Early Growth Response Protein 22 3     CMT4E2
Zinc Finger Protein Krox-202 3     E3 SUMO-Protein Ligase EGR22
AT5912 3     KROX-20, Drosophila, Homolog (Early Growth Response-2)2
Drosophila1     EC 6.3.2.-3
Early Growth Response 2 (Krox-20 Homolog, Drosophila)1     EGR-23

External Ids:    HGNC: 32391   Entrez Gene: 19592   Ensembl: ENSG000001228777   OMIM: 1290105   UniProtKB: P111613   
ORGUL members:         

Export aliases for EGR2 gene to outside databases

Previous GC identifers: GC10M063383 GC10M063658 GC10M064464 GC10M063916 GC10M064241 GC10M058563


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

TryGeneCards Plus

Entrez Gene summary for EGR2 Gene:
The protein encoded by this gene is a transcription factor with three tandem C2H2-type zinc fingers. Defects in
this gene are associated with Charcot-Marie-Tooth disease type 1D (CMT1D), Charcot-Marie-Tooth disease type 4E
(CMT4E), and with Dejerine-Sottas syndrome (DSS). Multiple transcript variants encoding two different isoforms
have been found for this gene. (provided by RefSeq, Oct 2008)

GeneCards Summary for EGR2 Gene:
EGR2 (early growth response 2) is a protein-coding gene. Diseases associated with EGR2 include charcot-marie-tooth neuropathy type 1d, and charcot-marie-tooth disease type 3. GO annotations related to this gene include transcription regulatory region DNA binding and sequence-specific DNA binding transcription factor activity. An important paralog of this gene is EGR3.

UniProtKB/Swiss-Prot: EGR2_HUMAN, P11161
Function: Sequence-specific DNA-binding transcription factor. Binds to two specific DNA sites located in the
promoter region of HOXA4
Function: E3 SUMO-protein ligase helping SUMO1 conjugation to its coregulators NAB1 and NAB2, whose sumoylation
down-regulates EGR2 own transcriptional activity

Gene Wiki entry for EGR2 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

TryGeneCards Plus
RefSeq DNA sequence at NCBI GenBank:
NC_000010.10  NT_030059.14  NC_018921.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the EGR2 gene promoter:
         SRF   SRF (504 AA)   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidEGR2 promoter sequence
   Search Chromatin IP Primers for EGR2

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat EGR2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 10q21.1   Ensembl cytogenetic band:  10q21.3   HGNC cytogenetic band: 10q21.1

EGR2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
EGR2 gene location

GeneLoc information about chromosome 10         GeneLoc Exon Structure

GeneLoc location for GC10M064571:  view genomic region     (about GC identifiers)

Start:
64,571,756 bp from pter      End:
64,679,660 bp from pter
Size:
107,905 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
About This Section

TryGeneCards Plus

UniProtKB/Swiss-Prot: EGR2_HUMAN, P11161 (See protein sequence)
Recommended Name: E3 SUMO-protein ligase EGR2  
Size: 476 amino acids; 50302 Da
Subunit: Interacts with HCFC1. Interacts with WWP2. Interacts with UBC9
Sequence caution: Sequence=AAA52372.1; Type=Erroneous initiation; Note=Translation N-terminally extended;
Sequence=AAA52372.1; Type=Frameshift; Positions=449;
Secondary accessions: B2R724 B3KRD7 Q68CZ5 Q8IV26 Q9UNA6
Alternative splicing: 2 isoforms:  P11161-1   P11161-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for EGR2: NX_P11161

Explore proteomics data for EGR2 at MOPED

Post-translational modifications: 

  • Ubiquitinated by WWP2 leading to proteasomal degradation (By similarity)1
  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See EGR2 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (4 alternative transcripts): 
    NP_000390.2  NP_001129649.1  NP_001129650.1  NP_001129651.1  

    ENSEMBL proteins: 
     ENSP00000242480   ENSP00000402040   ENSP00000387634  
    Reactome Protein details: P11161

    EGR2 Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Enzo Life Sciences proteins for EGR2
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    OriGene Protein Over-expression Lysate for EGR2
    OriGene Custom MassSpec
    OriGene Custom Protein Services for EGR2
    GenScript Custom Purified and Recombinant Proteins Services for EGR2
    Novus Biologicals EGR2 Proteins
    Novus Biologicals EGR2 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for EGR2

     
    Search eBioscience for Proteins for EGR2 

     
    antibodies-online proteins for EGR2 (11 products) 

     
    antibodies-online peptides for EGR2

    EGR2 Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    OriGene Antibodies for EGR2
    OriGene Custom Antibody Services for EGR2
    Novus Biologicals EGR2 Antibodies
    Abcam antibodies for EGR2
    Cloud-Clone Corp. Antibodies for EGR2
    ThermoFisher Antibodies for EGR2
    antibodies-online antibodies for EGR2 (63 products) 

    EGR2 Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for EGR2
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for EGR2
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for EGR2
    Cloud-Clone Corp. CLIAs for EGR2
    Search eBioscience for ELISAs for EGR2 
    antibodies-online kits for EGR2 (27 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    TryGeneCards Plus
    HGNC Gene Families:
    ZNF: Zinc fingers, C2H2-type

    4 InterPro protein domains:
     IPR015880 Znf_C2H2-like
     IPR013087 Znf_C2H2/integrase_DNA-bd
     IPR007087 Znf_C2H2
     IPR021849 DUF3446

    Graphical View of Domain Structure for InterPro Entry P11161

    ProtoNet protein and cluster: P11161

    1 Blocks protein domain: IPB007086 C2H2-type zinc finger signature

    UniProtKB/Swiss-Prot: EGR2_HUMAN, P11161
    Similarity: Belongs to the EGR C2H2-type zinc-finger protein family
    Similarity: Contains 3 C2H2-type zinc fingers


    Find genes that share domains with EGR2           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: EGR2_HUMAN, P11161
    Function: Sequence-specific DNA-binding transcription factor. Binds to two specific DNA sites located in the
    promoter region of HOXA4
    Function: E3 SUMO-protein ligase helping SUMO1 conjugation to its coregulators NAB1 and NAB2, whose sumoylation
    down-regulates EGR2 own transcriptional activity

         Genatlas biochemistry entry for EGR2:
    immediate early growth response,gene 2 (pAT591),involved in early myelination of the peripheral nervous system

         Enzyme Number (IUBMB): EC 6.3.2.-1

         Gene Ontology (GO): Selected molecular function terms (see all 10):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001102RNA polymerase II activating transcription factor binding ISS--
    GO:0003677DNA binding ----
    GO:0003682chromatin binding ISS--
    GO:0003700sequence-specific DNA binding transcription factor activity IDA14532282
    GO:0005515protein binding IPI14532282
         
    Find genes that share ontologies with EGR2           About GenesLikeMe


    Phenotypes:
         2 GenomeRNAi human phenotypes for EGR2:
     Increased gamma-H2AX phosphory  Synthetic lethal with cisplati 

         Selected MGI mutant phenotypes (inferred from 10 alleles(MGI details for Egr2) (see all 17):
     behavior/neurological  cellular  craniofacial  embryogenesis  growth/size/body 
     hearing/vestibular/ear  homeostasis/metabolism  integument  limbs/digits/tail  mortality/aging 
     nervous system  no phenotypic analysis  normal  reproductive system  respiratory system 

    Find genes that share phenotypes with EGR2           About GenesLikeMe

    Animal Models:
         MGI mouse knock-outs for EGR2: Egr2tm1Jmi Egr2tm3.1Pch Egr2tm1Grid

       genOway: Develop your customized and physiologically relevant rodent model for EGR2

    Transcription Factor Targeting: 
    Selected GeneGlobe predicted Target genes for EGR2 (see all 368):
    ABCD3,  ACOX1,  ACTR1A,  ADRM1,  AGPS,  AHCTF1,  AHNAK,  AKAP8L,  ALDH3B1,  AMIGO1

    Targeting motifs: HOMER Transcription Factor Regulatory Elements motif viewer 
                                          Consensus sequence:  NGCGTGGGCGGR 

    miRNA
    Products:
        
    miRTarBase miRNAs that target EGR2:
    hsa-mir-124-3p (MIRT022653), hsa-mir-100-5p (MIRT003417), hsa-mir-130b-3p (MIRT020183), hsa-mir-93-5p (MIRT028079), hsa-mir-150-5p (MIRT003222)

    Block miRNA regulation of human, mouse, rat EGR2 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate EGR2 (see all 75):
    hsa-miR-140-5p hsa-miR-106a hsa-miR-200a hsa-miR-374a hsa-miR-3921 hsa-miR-519a hsa-miR-1273d hsa-miR-4325
    SwitchGear 3'UTR luciferase reporter plasmidEGR2 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for EGR2
    Predesigned siRNA for gene silencing in human, mouse, rat EGR2

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for EGR2

    Clone
    Products:
         
    OriGene clones in human, mouse for EGR2 (see all 23)
    OriGene ORF clones in mouse, rat for EGR2
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 4): EGR2 (NM_000399)
    Sino Biological Human cDNA Clone for EGR2
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for EGR2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat EGR2

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for EGR2
    Browse ESI BIO Cell Lines and PureStem Progenitors for EGR2 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for EGR2


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Subcellular locations from UniProtKB/Swiss-Prot
    EGR2_HUMAN, P11161: Nucleus
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus ISS--
    GO:0005737cytoplasm ISS--

    Find genes that share ontologies with EGR2           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
    About This Section

    TryGeneCards Plus

    SuperPaths for EGR2 About   (see all 9)  
    See pathways by source

    SuperPathContained pathways About
    1L1CAM interactions
    Developmental Biology0.63
    2Calcineurin-regulated NFAT-dependent transcription in lymphocytes
    Calcineurin-regulated NFAT-dependent transcription in lymphocytes0.38
    3Fatty acid, triacylglycerol, and ketone body metabolism
    Transcriptional Regulation of White Adipocyte Differentiation0.38
    4Toll-like receptor signaling pathway
    Hepatitis B0.31
    5Viral carcinogenesis
    Viral carcinogenesis


    Find genes that share SuperPaths with EGR2           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    4 BioSystems Pathways for EGR2
        Adipogenesis
    BDNF signaling pathway
    IL4-mediated signaling events
    Calcineurin-regulated NFAT-dependent transcription in lymphocytes


    1 Reactome Pathway for EGR2
        Transcriptional regulation of white adipocyte differentiation


    3 Kegg Pathways  (Kegg details for EGR2):
        Hepatitis B
    HTLV-I infection
    Viral carcinogenesis

    UniProtKB/Swiss-Prot: EGR2_HUMAN, P11161
    Pathway: Protein modification; protein sumoylation

        Pathway & Disease-focused RT2 Profiler PCR Arrays including EGR2: 

              cAMP / Ca2+ Signaling PathwayFinder in human mouse rat
              NFKB Signaling Targets in human mouse rat
              T-Cell Anergy & Immune Tolerance in human mouse rat
              Synaptic Plasticity in human mouse rat
              Adipogenesis in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for EGR2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for EGR2 (P111612, 3 ENSP000002424804) via UniProtKB, MINT, STRING, and/or I2D (see all 79)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ACP5P136862, 3MINT-63454 I2D: score=5 
    MED31Q9Y3C72, 3, ENSP000002257284MINT-63455 I2D: score=5 STRING: ENSP00000225728
    HCFC1P516103, ENSP000003095554I2D: score=4 STRING: ENSP00000309555
    NAB2Q157423, ENSP000003001314I2D: score=2 STRING: ENSP00000300131
    WWP2O003083, ENSP000003482834I2D: score=2 STRING: ENSP00000348283
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 27):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006355regulation of transcription, DNA-templated ----
    GO:0006366transcription from RNA polymerase II promoter ISS--
    GO:0006611protein export from nucleus ISS--
    GO:0007420brain development TAS9537424
    GO:0007422peripheral nervous system development TAS9537424

    Find genes that share ontologies with EGR2           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
    About This Section

    TryGeneCards Plus
    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for EGR2

    5 Novoseek inferred chemical compound relationships for EGR2 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    zinc 44.1 13 2111009 (3), 9987007 (1), 8443122 (1), 8035792 (1) (see all 9)
    dbc-amp 25.8 2 1331750 (1)
    dexamethasone 8.45 3 1497907 (2), 1864967 (1)
    calcium 0 5 7812677 (2), 18678671 (1)
    tyrosine 0 1 10080384 (1)



    Find genes that share compounds with EGR2           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
    About This Section

    TryGeneCards Plus

    REFSEQ mRNAs for EGR2 gene (4 alternative transcripts): 
    NM_000399.3  NM_001136177.1  NM_001136178.1  NM_001136179.1  

    Unigene Cluster for EGR2:

    Early growth response 2
    Hs.1395  [show with all ESTs]
    Unigene Representative Sequence: BC035625
    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000242480(uc010qim.2 uc001jmi.3) ENST00000493899 ENST00000439032(uc010qio.2 uc009xph.3)
    ENST00000411732(uc010qin.2)
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat EGR2 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate EGR2 (see all 75):
    hsa-miR-140-5p hsa-miR-106a hsa-miR-200a hsa-miR-374a hsa-miR-3921 hsa-miR-519a hsa-miR-1273d hsa-miR-4325
    SwitchGear 3'UTR luciferase reporter plasmidEGR2 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for EGR2
    Predesigned siRNA for gene silencing in human, mouse, rat EGR2
    Clone
    Products:
         
    OriGene clones in human, mouse for EGR2 (see all 23)
    OriGene ORF clones in mouse, rat for EGR2
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 4): EGR2 (NM_000399)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for EGR2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat EGR2
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for EGR2
    OriGene qSTAR qPCR primer pairs in human, mouse for EGR2
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat EGR2
      QuantiTect SYBR Green Assays in human, mouse, rat EGR2
      QuantiFast Probe-based Assays in human, mouse, rat EGR2

    Additional mRNA sequence: 

    AF139463.1 AK091399.1 AK296830.1 AK312813.1 BC035625.1 CR749641.1 J04076.1 

    7 DOTS entries:

    DT.100748388  DT.211438  DT.95159416  DT.121263753  DT.121263774  DT.100692586  DT.92421282 

    Selected AceView cDNA sequences (see all 69):

    AK091399 BG743293 AF139463 BI772084 BQ716551 AU141563 BC035625 AA593330 
    CA308591 NM_000399 BI002784 AI264201 AI347984 AI588869 J04076 BX414563 
    AU142101 BQ575265 AA018188 AI801548 AI367702 AW338296 AL569994 AW014396 

    GeneLoc Exon Structure

    4 Alternative Splicing Database (ASD) splice patterns (SP) for EGR2    About this scheme

    ExUns: 1 ^ 2 ^ 3a · 3b · 3c · 3d ^ 4a · 4b · 4c · 4d
    SP1:              -     -                                       
    SP2:                    -                                       
    SP3:                          -                                 
    SP4:                                                            


    ECgene alternative splicing isoforms for EGR2

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TryGeneCards Plus

    EGR2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TAAATGGGTT
    EGR2 Expression
    About this image


    EGR2 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 15) fully expand
     
     Peripheral Nervous System (Nervous System)    fully expand to see all 4 entries
             Myelinating Schwann Cells Peripheral Nerve Domain
             Schwann-like cells
     
     Schwann Cells (Nervous System)    fully expand to see all 3 entries
             Schwann-like cells
     
     Ovary (Reproductive System)    fully expand to see all 4 entries
             Mature Granulosa Cells Antral Follicle
             Secondary follicles
     
     Epithelial Cells
             Fetal Precortex Cells Hair Shaft
     
     Tendon & Ligament (Muscoskeletal System)    fully expand to see all 2 entries
             Early Tenocyte Cells Limb Tendon Primordia
    EGR2 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    EGR2 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.1395
        Pathway & Disease-focused RT2 Profiler PCR Arrays including EGR2: 
              cAMP / Ca2+ Signaling PathwayFinder in human mouse rat
              NFKB Signaling Targets in human mouse rat
              T-Cell Anergy & Immune Tolerance in human mouse rat
              Synaptic Plasticity in human mouse rat
              Adipogenesis in human mouse rat

    Primer
    Products:
    OriGene qPCR primer pairs and template standards for EGR2
    OriGene qSTAR qPCR primer pairs in human, mouse for EGR2
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat EGR2
    QuantiTect SYBR Green Assays in human, mouse, rat EGR2
    QuantiFast Probe-based Assays in human, mouse, rat EGR2
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for EGR2

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    TryGeneCards Plus

    This gene was present in the common ancestor of animals and fungi.

    Orthologs for EGR2 gene from Selected species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Egr21 , 5 early growth response 21, 5 86.24(n)1
    89.57(a)1
      10 (34.96 cM)5
    136541  NM_010118.31  NP_034248.21 
     675354755 
    lizard
    (Anolis carolinensis)
    Reptilia EGR26
    early growth response 2
    60(a)
    1 ↔ 1
    GL343204.1(2650531-2656564)
    African clawed frog
    (Xenopus laevis)
    Amphibia egr2-A2 early growth response 2 (Krox-20 homolog) 74.77(n)    S56884.1 
    zebrafish
    (Danio rerio)
    Actinopterygii egr2b2 early growth response 2b 74.33(n)   30190  NM_130997.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta sr3 tracheal cell migration (sensu Insecta)
    RNA polymerase more
    78(a)     --
    worm
    (Caenorhabditis elegans)
    Secernentea C27C12.23 Zinc finger, C2H2 type (3 domains) 83(a)
    (best of 2)
      X(14881084-14882208)   --
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes (YER130C)4 Protein of unknown function; transcription is regulated more   --   5(422446-421115) 856867  NP_011056.1 


    ENSEMBL Gene Tree for EGR2 (if available)
    TreeFam Gene Tree for EGR2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

    TryGeneCards Plus
    Paralogs for EGR2 gene
    EGR32  EGR12  EGR42  WT12  
    3 SIMAP similar genes for EGR2 using alignment to 1 protein entry:     EGR2_HUMAN:
    EGR3    EGR1    ZNF323

    Find genes that share paralogs with EGR2           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

    TryGeneCards Plus

    Selected SNPs for EGR2 (see all 181)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 10 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0299584
    Charcot-Marie-Tooth disease 1D (CMT1D)4--see VAR_0299582 R C mis40--------
    VAR_0077384
    Charcot-Marie-Tooth disease 1D (CMT1D)4--see VAR_0077382 R W mis40--------
    VAR_0077354
    Neuropathy, congenital hypomyelinating or amyelinating (CHN)4--see VAR_0077352 I N mis40--------
    VAR_0098754
    Charcot-Marie-Tooth disease 1D (CMT1D)4--see VAR_0098752 R H mis40--------
    VAR_0299594
    Charcot-Marie-Tooth disease 1D (CMT1D)4--see VAR_0299592 D Y mis40--------
    VAR_0098744
    Dejerine-Sottas syndrome (DSS)4--see VAR_0098742 R W mis40--------
    VAR_0077364
    Charcot-Marie-Tooth disease 1D (CMT1D)4--see VAR_0077362 D V mis40--------
    rs1048941591,2
    Cpathogenic164945911(-) TTGCCC/TGGAGT 8 R W mis10--------
    rs1048941601,2
    Cpathogenic164945989(-) GCAGTG/TACCAC 8 D Y mis10--------
    rs1048941611,2
    Cpathogenic164946061(-) TGACAC/TGGCAC 8 R W mis10--------

    HapMap Linkage Disequilibrium report for EGR2 (64571756 - 64679660 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for EGR2:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv895570CNV Loss21882294

    Human Gene Mutation Database (HGMD): EGR2
    Locus Specific Mutation Databases (LSDB): EGR2

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing EGR2
    DNA2.0 Custom Variant and Variant Library Synthesis for EGR2

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    TryGeneCards Plus
    OMIM gene information: 129010   
    OMIM disorders: 605253  607678  145900  
    UniProtKB/Swiss-Prot: EGR2_HUMAN, P11161
  • Neuropathy, congenital hypomyelinating or amyelinating (CHN) [MIM:605253]: A severe degenerating
    neuropathy that results from a congenital impairment in myelin formation. It is clinically characterized by early
    onset of hypotonia, areflexia, distal muscle weakness, and very slow nerve conduction velocities (as low as
    3m/s). Some patients manifest nearly complete absence of spontaneous limb movements, respiratory distress at
    birth, and complete absence of myelin shown by electron microscopy of peripheral nerves. Inheritance can be
    autosomal dominant or recessive. Note=The disease is caused by mutations affecting the gene represented in this
    entry. Patients affected by the amyelinating form carry a causative, homozygous deletion encompassing a
    myelin-specific enhancer of EGR2 (PubMed:22522483)
  • Charcot-Marie-Tooth disease 1D (CMT1D) [MIM:607678]: A dominant demyelinating form of Charcot-Marie-Tooth
    disease, a disorder of the peripheral nervous system, characterized by progressive weakness and atrophy,
    initially of the peroneal muscles and later of the distal muscles of the arms. Charcot-Marie-Tooth disease is
    classified in two main groups on the basis of electrophysiologic properties and histopathology: primary
    peripheral demyelinating neuropathies (designated CMT1 when they are dominantly inherited) and primary peripheral
    axonal neuropathies (CMT2). Demyelinating neuropathies are characterized by severely reduced nerve conduction
    velocities (less than 38 m/sec), segmental demyelination and remyelination with onion bulb formations on nerve
    biopsy, slowly progressive distal muscle atrophy and weakness, absent deep tendon reflexes, and hollow feet.
    Note=The disease is caused by mutations affecting the gene represented in this entry
  • Dejerine-Sottas syndrome (DSS) [MIM:145900]: A severe degenerating neuropathy of the demyelinating
    Charcot-Marie-Tooth disease category, with onset by age 2 years. Characterized by motor and sensory neuropathy
    with very slow nerve conduction velocities, increased cerebrospinal fluid protein concentrations, hypertrophic
    nerve changes, delayed age of walking as well as areflexia. There are both autosomal dominant and autosomal
    recessive forms of Dejerine-Sottas syndrome. Note=The disease is caused by mutations affecting the gene
    represented in this entry

  • 13 diseases for EGR2:    
    About MalaCards
    charcot-marie-tooth neuropathy type 1d    charcot-marie-tooth disease type 3    neuropathy, congenital hypomyelinating, 1    charcot-marie-tooth neuropathy type 4e
    charcot-marie-tooth disease type 1d    dejerine-sottas disease, autosomal recessive    charcot-marie-tooth disease type 4    charcot-marie-tooth neuropathy type 1
    charcot-marie-tooth disease type 1    charcot-marie-tooth neuropathy type 4    charcot-marie-tooth disease type 4e    tooth disease
    charcot-marie-tooth disease

    3 diseases from the University of Copenhagen DISEASES database for EGR2:
    Neuropathy     Myopathy     Demyelinating polyneuropathy

    Find genes that share disorders with EGR2           About GenesLikeMe

    Selected Novoseek inferred disease relationships for EGR2 gene (see all 13)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    neuropathy, congenital hypomyelinating 95.3 6 11523566 (1), 12030330 (1), 9537424 (1), 16872830 (1) (see all 6)
    dejerine-sottas disease 92 6 11523566 (2), 12030330 (1), 12736090 (1), 10371530 (1) (see all 5)
    charcot-marie-tooth disease 91.6 16 19691535 (2), 15241803 (2), 11523566 (1), 20513111 (1) (see all 14)
    myelinopathy 88.3 6 9537424 (2), 11523566 (1), 10369870 (1), 12030330 (1)
    hereditary peripheral neuropathy 83 1 16988048 (1)
    dental disorder 60.8 2 11493034 (1), 11239949 (1)
    sensory neuropathy 57.6 2 16106622 (1), 19327944 (1)
    demyelination 46.6 2 16988048 (2)
    wilms tumor 43.6 4 1367123 (1), 2072895 (1), 14965266 (1), 8584037 (1)
    polyneuropathy 34.2 1 16106622 (1)

    GeneTests: EGR2
    GeneReviews: EGR2
    Genetic Association Database (GAD): EGR2
    Human Genome Epidemiology (HuGE) Navigator: EGR2 (15 documents)

    Export disorders for EGR2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    TryGeneCards Plus

    PubMed articles for EGR2 gene, integrated from 10 sources (see all 174):
    (articles sorted by number of sources associating them with EGR2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. A novel mutation (D305V) in the early growth response 2 gene is associated with severe Charcot-Marie-Tooth type 1 disease. (PubMed id 10502832)1, 2, 4, 9 Bellone E.... Mandich P. (Hum. Mutat. 1999)
    2. The serum and TPA responsive promoter and intron-exon structure of EGR2, a human early growth response gene encoding a zinc finger protein. (PubMed id 2111009)1, 2, 9 Rangnekar V.M.... Sukhatme V.P. (Nucleic Acids Res. 1990)
    3. Mutations in the early growth response 2 (EGR2) gene are associated with hereditary myelinopathies. (PubMed id 9537424)1, 2, 9 Warner L.E.... Lupski J.R. (Nat. Genet. 1998)
    4. Novel EGR2 mutation R359Q is associated with CMT type 1 and progressive scoliosis. (PubMed id 16198564)1, 4, 9 MikesovA! E....Seeman P. (Neuromuscul. Disord. 2005)
    5. Two missense mutations of EGR2 R359W and GJB1 V136A in a Charcot- Marie-Tooth disease family. (PubMed id 15947997)1, 2, 9 Chung K.W.... Choi B.O. (Neurogenetics 2005)
    6. Screening of the early growth response 2 gene in Japanese patients with Charcot-Marie-Tooth disease type 1. (PubMed id 12736090)1, 2, 9 Numakura C.... Hayasaka K. (J. Neurol. Sci. 2003)
    7. Mutational analysis of PMP22, MPZ, GJB1, EGR2 and NEFL in Korean Charcot-Marie-Tooth neuropathy patients. (PubMed id 15241803)1, 2, 9 Choi B.-O.... Chung K.W. (Hum. Mutat. 2004)
    8. A novel missense mutation in the early growth response 2 gene associated with late-onset Charcot-Marie-Tooth disease type 1. (PubMed id 11239949)1, 2, 9 Yoshihara T.... Sobue G. (J. Neurol. Sci. 2001)
    9. Cranial nerve involvement in CMT disease type 1 due to early growth response 2 gene mutation. (PubMed id 10762521)1, 2, 9 Pareyson D.... Sghirlanzoni A. (Neurology 2000)
    10. Mutation frequency for Charcot-Marie-Tooth disease type 1 in the Chinese population is similar to that in the global ethnic patients. (PubMed id 16912585)1, 4, 9 Song S....Zhong N. (Genet. Med. 2006)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

    TryGeneCards Plus
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

    TryGeneCards Plus
    Entrez Gene: 1959 HGNC: 3239 AceView: EGR2 Ensembl:ENSG00000122877 euGenes: HUgn1959
    ECgene: EGR2 Kegg: 1959 H-InvDB: EGR2

    (According to HUGE)
    About This Section

    TryGeneCards Plus
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

    TryGeneCards Plus
    NameDescription
    PharmGKB entry for EGR2 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for EGR2 Genetics and Cytogenetics in Oncology and Haematology
    Inherited peripheral neuropathies mutation dbhttp://www.molgen.ua.ac.be/CMTMutations/
    GeneReviewshttp://www.ncbi.nlm.nih.gov/books/NBK1116/?term=EGR2[genesymbol]

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

    TryGeneCards Plus
    Patent Information for EGR2 gene:
    Search GeneIP for patents involving EGR2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from genOway)
    About This Section

    TryGeneCards Plus

     
     EMD Millipore genomic analysis products

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Enzyme Activity Assays/Reagents  
     Browse ELISpot/FluoroSpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Luminex Assays  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Recombinant/Natural Proteins   Browse Stem Cell Products  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     OriGene Antibodies for EGR2   OriGene RNAi products in human, mouse, rat for EGR2  
     OriGene qPCR primer pairs and template standards for EGR2   OriGene Protein Over-expression Lysate for EGR2  
     OriGene Custom Mass Spec   OriGene clones in human, mouse for EGR2  
     OriGene qSTAR qPCR primer pairs in human, mouse for EGR2   Browse OriGene full length recombinant human proteins expressed in human HEK293 cells  
     OriGene ORF clones in mouse, rat for EGR2   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for EGR2   OriGene Custom Protein Services for EGR2  

     
     
     Block miRNA regulation of human, mouse, rat EGR2 using miScript Target Protectors SeqTarget long-range PCR primers for resequencing EGR2
     DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat EGR2 Predesigned siRNA for gene silencing in human, mouse, rat EGR2
     QuantiFast Probe-based Assays in human, mouse, rat EGR2 QuantiTect SYBR Green Assays in human, mouse, rat EGR2
     PCR Arrays including human, mouse, rat EGR2 Search Chromatin IP Primers for EGR2
     Pre-validated RT2 qPCR Primer Assay in human, mouse, rat EGR2  GeneGlobe Interaction Network for EGR2
     Regulatory tfbs in EGR2 promoter
     GenScript Custom Purified and Recombinant Proteins Services for EGR2 GenScript cDNA clones with any tag delivered in your preferred vector for EGR2
     GenScript Custom Assay Services for EGR2 GenScript Custom overexpressing Cell Line Services for EGR2
     CloneReady with Over 120,000 Genes  Gene Synthesis: Any Gene in Any Vector
     Vector-based siRNA and miRNA, Ready for Transfection Gene Mutant Library, Variants up to 10^11
     Plasmid Preparation Custom Peptide Services
     Search for Antibodies & Assays

     Search Tocris compounds for EGR2
     Browse Sino Biological Proteins
     Browse Sino Biological Cell Lysates
     cDNA Clones for EGR2
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Proteins for EGR2
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

     Novus Tissue Slides
     EGR2 antibodies
     EGR2 proteins
     EGR2 lysates
     Antibodies for EGR2
     See all of Abcam's Antibodies, Kits and Proteins for EGR2
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins
     Proteins for EGR2
     Antibodies for EGR2
     ELISAs for EGR2
     CLIAs for EGR2



     Browse ESI BIO Cell Lines and PureStem Progenitors for EGR2
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for EGR2
     SwitchGear 3'UTR luciferase reporter plasmids for EGR2
     SwitchGear Promoter luciferase reporter plasmids for EGR2
     ThermoFisher Antibodies for EGR2
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat EGR2
     Browse compounds at ApexBio
     Search Addgene for plasmids for EGR2
      Search eBioscience for proteins for EGR2
      Search eBioscience for elisas for EGR2
      eBioscience FlowRNA Probe Sets
     genOway: Develop your customized and physiologically relevant rodent model for EGR2
     antibodies-online antibodies for EGR2 (63 products)
     antibodies-online kits for EGR2 (27 products)
     antibodies-online peptides for EGR2
     antibodies-online proteins for EGR2 (11 products)
           
    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014 , 21 Aug 2014 , 8 Sep 2014 , 7 Oct 2014

    View Random Gene

    Category
    (GIFtS: )
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      EGR2 gene at Home site.
    Version: 3.12.252 27 Nov 2014
    hostname: 356977-web1.xennexinc.com index build: 128 solr: 1.4