Aliases for EGR1 Gene
External Ids for EGR1 Gene
Previous GeneCards Identifiers for EGR1 Gene
The protein encoded by this gene belongs to the EGR family of C2H2-type zinc-finger proteins. It is a nuclear protein and functions as a transcriptional regulator. The products of target genes it activates are required for differentitation and mitogenesis. Studies suggest this is a cancer suppressor gene. [provided by RefSeq, Dec 2014]
GeneCards Summary for EGR1 Gene
EGR1 (Early Growth Response 1) is a Protein Coding gene. Diseases associated with EGR1 include Familial Tumoral Calcinosis and Wilms Tumor Susceptibility-5. Among its related pathways are Immune response IFN alpha/beta signaling pathway and Development_Leptin signaling via JAK/STAT and MAPK cascades. GO annotations related to this gene include transcription factor activity, sequence-specific DNA binding and transcription factor binding. An important paralog of this gene is EGR2.
UniProtKB/Swiss-Prot for EGR1 Gene
Transcriptional regulator. Recognizes and binds to the DNA sequence 5-CGCCCCCGC-3(EGR-site). Activates the transcription of target genes whose products are required for mitogenesis and differentiation.