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Aliases for EGR1 Gene

Aliases for EGR1 Gene

  • Early Growth Response 1 2 3
  • Nerve Growth Factor-Induced Protein A 2 3 4
  • Transcription Factor ETR103 2 3 4
  • Zinc Finger Protein 225 2 3 4
  • Transcription Factor Zif268 3 4
  • Zinc Finger Protein Krox-24 3 4
  • NGFI-A 3 4
  • ZNF225 3 4
  • AT225 3 4
  • EGR-1 3 4
  • Early Growth Response Protein 1 2
  • KROX-24 3
  • ZIF-268 3
  • KROX24 4
  • G0S30 3
  • TIS8 3

External Ids for EGR1 Gene

Previous GeneCards Identifiers for EGR1 Gene

  • GC05P137675
  • GC05P138476
  • GC05P137832
  • GC05P137877
  • GC05P137829
  • GC05P137801
  • GC05P132991

Summaries for EGR1 Gene

Entrez Gene Summary for EGR1 Gene

  • The protein encoded by this gene belongs to the EGR family of C2H2-type zinc-finger proteins. It is a nuclear protein and functions as a transcriptional regulator. The products of target genes it activates are required for differentitation and mitogenesis. Studies suggest this is a cancer suppressor gene. [provided by RefSeq, Dec 2014]

GeneCards Summary for EGR1 Gene

EGR1 (Early Growth Response 1) is a Protein Coding gene. Diseases associated with EGR1 include familial tumoral calcinosis and tumoral calcinosis. Among its related pathways are Immune System and Interleukin receptor SHC signaling. GO annotations related to this gene include transcription factor activity, sequence-specific DNA binding and transcription factor binding. An important paralog of this gene is WT1.

UniProtKB/Swiss-Prot for EGR1 Gene

  • Transcriptional regulator. Recognizes and binds to the DNA sequence 5-CGCCCCCGC-3(EGR-site). Activates the transcription of target genes whose products are required for mitogenesis and differentiation

Gene Wiki entry for EGR1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for EGR1 Gene

Genomics for EGR1 Gene

Regulatory Elements for EGR1 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for EGR1 Gene

Chromosome:
5
Start:
138,465,490 bp from pter
End:
138,469,315 bp from pter
Size:
3,826 bases
Orientation:
Plus strand

Genomic View for EGR1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for EGR1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for EGR1 Gene

Proteins for EGR1 Gene

  • Protein details for EGR1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P18146-EGR1_HUMAN
    Recommended name:
    Early growth response protein 1
    Protein Accession:
    P18146

    Protein attributes for EGR1 Gene

    Size:
    543 amino acids
    Molecular mass:
    57507 Da
    Quaternary structure:
    • Interacts with SNAI1 and SP1 upon 12-O-tetradecanoylphorbol-13-acetate (TPA) induction.

    Three dimensional structures from OCA and Proteopedia for EGR1 Gene

neXtProt entry for EGR1 Gene

Proteomics data for EGR1 Gene at MOPED

Post-translational modifications for EGR1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for EGR1 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for EGR1 (EGR1)

No data available for DME Specific Peptides for EGR1 Gene

Domains & Families for EGR1 Gene

Gene Families for EGR1 Gene

Protein Domains for EGR1 Gene

Graphical View of Domain Structure for InterPro Entry

P18146

UniProtKB/Swiss-Prot:

EGR1_HUMAN :
  • Belongs to the EGR C2H2-type zinc-finger protein family.
  • Contains 3 C2H2-type zinc fingers.
Family:
  • Belongs to the EGR C2H2-type zinc-finger protein family.
Similarity:
  • Contains 3 C2H2-type zinc fingers.
genes like me logo Genes that share domains with EGR1: view

Function for EGR1 Gene

Molecular function for EGR1 Gene

GENATLAS Biochemistry:
immediate early growth response,gene 1 (pAT225),nerve growth factor induced clone A,specifically expressed in Schwann cells,induced by a wide variety of extracellular stimuli,involved in cell proliferation,macrophage differentiation,synaptic activation and long term potentiation,coactivated by CREBBP
UniProtKB/Swiss-Prot Function:
Transcriptional regulator. Recognizes and binds to the DNA sequence 5-CGCCCCCGC-3(EGR-site). Activates the transcription of target genes whose products are required for mitogenesis and differentiation
UniProtKB/Swiss-Prot Induction:
By growth factors

Gene Ontology (GO) - Molecular Function for EGR1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000976 transcription regulatory region sequence-specific DNA binding IDA 18718911
GO:0000977 RNA polymerase II regulatory region sequence-specific DNA binding IDA 14979875
GO:0000979 RNA polymerase II core promoter sequence-specific DNA binding IEA --
GO:0000982 transcription factor activity, RNA polymerase II core promoter proximal region sequence-specific binding --
GO:0001077 transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding IEA --
genes like me logo Genes that share ontologies with EGR1: view
genes like me logo Genes that share phenotypes with EGR1: view

Animal Models for EGR1 Gene

MGI Knock Outs for EGR1:

Animal Model Products

Transcription Factor Targets for EGR1 Gene

Selected GeneGlobe predicted Target genes for EGR1
Targeted motifs for EGR1 Gene
HOMER Transcription Factor Regulatory Elements motif EGR1
  • Consensus sequence: TGCGTGGGYG Submotif: canonical Cell Type: K562 GEO ID: GSE32465

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) for EGR1 Gene

Localization for EGR1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for EGR1 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for EGR1 Gene COMPARTMENTS Subcellular localization image for EGR1 gene
Compartment Confidence
nucleus 5
cytoskeleton 2
cytosol 2
extracellular 2
plasma membrane 2
endoplasmic reticulum 1
mitochondrion 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for EGR1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus ISS --
GO:0005654 nucleoplasm TAS --
GO:0005737 cytoplasm ISS --
genes like me logo Genes that share ontologies with EGR1: view

Pathways & Interactions for EGR1 Gene

genes like me logo Genes that share pathways with EGR1: view

PCR Array Products

SIGNOR curated interactions for EGR1 Gene

Is activated by:

Gene Ontology (GO) - Biological Process for EGR1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000122 negative regulation of transcription from RNA polymerase II promoter IEA --
GO:0001975 response to amphetamine IEA --
GO:0006355 regulation of transcription, DNA-templated --
GO:0006366 transcription from RNA polymerase II promoter IDA 19057511
GO:0007611 learning or memory IEA --
genes like me logo Genes that share ontologies with EGR1: view

Drugs & Compounds for EGR1 Gene

(68) Drugs for EGR1 Gene - From: NovoSeek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Amphetamine Approved, Illicit Pharma 96
Atropine Approved Pharma Antagonist MAChRs antagonist 101
Carbachol Approved Pharma Full agonist, Agonist 3
Chloramphenicol Approved Pharma 6
Cisplatin Approved Pharma Inhibits DNA synthesis,chemotherapy drug, Platinum, Potent pro-apoptotic anticancer agent; activates caspase-3 2437

(54) Additional Compounds for EGR1 Gene - From: NovoSeek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
1,25 DIHYDROXY VITAMIN D3
12-O-Tetradecanoylphorbol 13-acetate
15-deoxy-delta-12,14-prostaglandin j2
87893-55-8
5fluorouracil
Actinomycin D
genes like me logo Genes that share compounds with EGR1: view

Transcripts for EGR1 Gene

mRNA/cDNA for EGR1 Gene

(1) REFSEQ mRNAs :
(8) Additional mRNA sequences :
(292) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for EGR1 Gene

Early growth response 1:
Representative Sequences:

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for EGR1 Gene

No ASD Table

Relevant External Links for EGR1 Gene

GeneLoc Exon Structure for
EGR1
ECgene alternative splicing isoforms for
EGR1

Expression for EGR1 Gene

mRNA expression in normal human tissues for EGR1 Gene

mRNA differential expression in normal tissues according to GTEx for EGR1 Gene

This gene is overexpressed in Fallopian Tube (x9.0) and Adipose - Visceral (Omentum) (x4.2).

SOURCE GeneReport for Unigene cluster for EGR1 Gene Hs.326035

genes like me logo Genes that share expression patterns with EGR1: view

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for EGR1 Gene

Orthologs for EGR1 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for EGR1 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia EGR1 35
  • 89.67 (n)
  • 92.02 (a)
EGR1 36
  • 94 (a)
OneToOne
dog
(Canis familiaris)
Mammalia EGR1 35
  • 89.59 (n)
  • 92.98 (a)
EGR1 36
  • 94 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Egr1 35
  • 86.77 (n)
  • 91.87 (a)
Egr1 16
Egr1 36
  • 93 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia EGR1 35
  • 98.11 (n)
  • 97.46 (a)
rat
(Rattus norvegicus)
Mammalia Egr1 35
  • 86.13 (n)
  • 91.12 (a)
chicken
(Gallus gallus)
Aves EGR1 35
  • 72.74 (n)
  • 75.25 (a)
EGR1 36
  • 75 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia egr1 35
  • 71.51 (n)
  • 76.21 (a)
Str.19374 35
African clawed frog
(Xenopus laevis)
Amphibia Xl.637 35
zebrafish
(Danio rerio)
Actinopterygii egr1 35
  • 69.1 (n)
  • 66.53 (a)
egr1 36
  • 64 (a)
OneToOne
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.9236 35
fruit fly
(Drosophila melanogaster)
Insecta sr 37
  • 76 (a)
sr 36
  • 12 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea C27C12.2 37
  • 84 (a)
Y55F3AM.7 37
  • 64 (a)
egrh-3 36
  • 24 (a)
ManyToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes MIG2 36
  • 14 (a)
ManyToMany
MIG3 36
  • 14 (a)
ManyToMany
Species with no ortholog for EGR1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for EGR1 Gene

ENSEMBL:
Gene Tree for EGR1 (if available)
TreeFam:
Gene Tree for EGR1 (if available)

Paralogs for EGR1 Gene

Paralogs for EGR1 Gene

(2) SIMAP similar genes for EGR1 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with EGR1: view

Variants for EGR1 Gene

Sequence variations from dbSNP and Humsavar for EGR1 Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type MAF
VAR_029330 -
VAR_029331 -
VAR_029332 -
VAR_052712 -

Structural Variations from Database of Genomic Variants (DGV) for EGR1 Gene

Variant ID Type Subtype PubMed ID
nsv5024 CNV Insertion 18451855
nsv528851 CNV Loss 19592680
nsv5025 CNV Loss 18451855

Variation tolerance for EGR1 Gene

Residual Variation Intolerance Score: 9.66% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.49; 29.02% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for EGR1 Gene

HapMap Linkage Disequilibrium report
EGR1
Human Gene Mutation Database (HGMD)
EGR1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for EGR1 Gene

Disorders for EGR1 Gene

MalaCards: The human disease database

(7) MalaCards diseases for EGR1 Gene - From: DISEASES, NovoSeek, and GeneCards

Disorder Aliases PubMed IDs
familial tumoral calcinosis
  • galnt3-cdg
tumoral calcinosis
  • calcinosis, tumoral
monocytic leukemia
  • schilling's leukemia
wilms tumor susceptibility-5
  • wilms tumor
pheochromocytoma
  • pheochromocytoma, modifier of
- elite association
Search EGR1 in MalaCards View complete list of genes associated with diseases

Relevant External Links for EGR1

Genetic Association Database (GAD)
EGR1
Human Genome Epidemiology (HuGE) Navigator
EGR1
Tumor Gene Database (TGDB):
EGR1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
EGR1
genes like me logo Genes that share disorders with EGR1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for EGR1 Gene

Publications for EGR1 Gene

  1. Vascular endothelial growth factor activation of endothelial cells is mediated by early growth response-3. (PMID: 19965691) Suehiro J. … Minami T. (Blood 2010) 23 67
  2. The effect of siRNA-Egr-1 and camptothecin on growth and chemosensitivity of breast cancer cell lines. (PMID: 20204305) Parra E. … Ferreira J. (Oncol. Rep. 2010) 23 67
  3. Downregulation of stathmin expression is mediated directly by Egr1 and associated with p53 activity in lung cancer cell line A549. (PMID: 19786090) Fang L. … Huizhong Z. (Cell. Signal. 2010) 23 67
  4. Inhibition of protein kinase Cdelta reduces tristetraprolin expression by destabilizing its mRNA in activated macrophages. (PMID: 19925787) LeppAonen T. … Moilanen E. (Eur. J. Pharmacol. 2010) 23 67
  5. A role for nitric oxide-driven retrograde signaling in the consolidation of a fear memory. (PMID: 20161806) Overeem K.A. … Schafe G.E. (Front Behav Neurosci 2010) 23 67

Products for EGR1 Gene

Sources for EGR1 Gene

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