Aliases for EGR1 Gene
External Ids for EGR1 Gene
Previous GeneCards Identifiers for EGR1 Gene
The protein encoded by this gene belongs to the EGR family of C2H2-type zinc-finger proteins. It is a nuclear protein and functions as a transcriptional regulator. The products of target genes it activates are required for differentitation and mitogenesis. Studies suggest this is a cancer suppressor gene. [provided by RefSeq, Dec 2014]
GeneCards Summary for EGR1 Gene
EGR1 (Early Growth Response 1) is a Protein Coding gene. Diseases associated with EGR1 include familial tumoral calcinosis and fibrosarcoma. Among its related pathways are Integrated Pancreatic Cancer Pathway and Glucocorticoid receptor regulatory network. GO annotations related to this gene include sequence-specific DNA binding transcription factor activity and transcription factor binding. An important paralog of this gene is WT1.
UniProtKB/Swiss-Prot for EGR1 Gene
Transcriptional regulator. Recognizes and binds to the DNA sequence 5-CGCCCCCGC-3(EGR-site). Activates the transcription of target genes whose products are required for mitogenesis and differentiation