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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

EGR1 Gene

protein-coding GIFtS: 70
GCID: GC05P137801

early growth response 1

Explore 110 diseases affiliated with
EGR1 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Early Growth Response 1¹ ²		Nerve Growth Factor-Induced Protein A² ³
AT225¹ ² ³		Transcription Factor ETR103² ³
NGFI-A¹ ² ³		Transcription Factor Zif268² ³
ZNF225¹ ² ³		Zinc Finger Protein 225² ³
G0S30¹ ²		Zinc Finger Protein Krox-24² ³
KROX-24¹ ²		EGR-1² ³
TIS8¹ ²		Early Growth Response Protein 1²
ZIF-268¹ ²		KROX24³

External Ids:	HGNC: 3238¹	Entrez Gene: 1958²	Ensembl: ENSG00000120738⁷	OMIM: 128990⁵	UniProtKB: P18146³

Export aliases for EGR1 gene to outside databases

Previous GC identifers: GC05P137675 GC05P138476 GC05P137832 GC05P137877 GC05P137829 GC05P132991

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for EGR1:

The protein encoded by this gene belongs to the EGR family of C2H2-type zinc-finger proteins. It is a nuclear protein

and functions as a transcriptional regulator. The products of target genes it activates are required for

differentitation and mitogenesis. Studies suggest this is a cancer suppresor gene. (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: EGR1_HUMAN, P18146

Function: Transcriptional regulator. Recognizes and binds to the DNA sequence 5'-CGCCCCCGC-3'(EGR-site). Activates the

transcription of target genes whose products are required for mitogenesis and differentiation

Gene Wiki entry for EGR1

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000005.9 NC_018916.1 NT_034772.6

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the EGR1 gene promoter:
GR CREB GR-beta deltaCREB GR-alpha c-Ets-1
Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): EGR1 promoter sequence

Search SABiosciences Chromatin IP Primers for EGR1

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat EGR1

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 5q31.1 Ensembl cytogenetic band: 5q31.2 HGNC cytogenetic band: 5q23-q31

EGR1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
EGR1 gene location

GeneLoc information about chromosome 5 GeneLoc Exon Structure

GeneLoc location for GC05P137801: view genomic region (about GC identifiers)

Start:	137,801,179 bp from pter	End:	137,805,004 bp from pter
Size:	3,826 bases	Orientation:	plus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: EGR1_HUMAN, P18146 (See protein sequence)

Recommended Name: Early growth response protein 1

Size: 543 amino acids; 57507 Da

Subunit: Interacts with SNAI1 and SP1 upon 12-O-tetradecanoylphorbol-13-acetate (TPA) induction

Subcellular location: Nucleus

Explore the universe of human proteins at neXtProt for EGR1: NX_P18146

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_P18146

EGR1 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins: NP_001955.1

ENSEMBL proteins:

ENSP00000239938

Reactome Protein details: P18146
Human Recombinant Protein Products:

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	Uscn Proteins for EGR1

Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005634	nucleus	ISS	--
GO:0005654	nucleoplasm	TAS	--
GO:0005737	cytoplasm	ISS	--

EGR1 for ontologies About GeneDecksing

EGR1 Antibody Products:

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	Uscn ELISAs and CLIAs for EGR1

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

EGR1 for domains About GeneDecksing

5 InterPro domains/families:

IPR015880 Znf_C2H2-like

IPR021839 DUF3432

IPR013087 Znf_C2H2/integrase_DNA-bd

IPR007087 Znf_C2H2

IPR021849 DUF3446

Graphical View of Domain Structure for InterPro Entry P18146

ProtoNet protein and cluster: P18146

1 Blocks protein family: IPB007086 C2H2-type zinc finger signature

UniProtKB/Swiss-Prot: EGR1_HUMAN, P18146

Similarity: Belongs to the EGR C2H2-type zinc-finger protein family

Similarity: Contains 3 C2H2-type zinc fingers

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

UniProtKB/Swiss-Prot: EGR1_HUMAN, P18146

Function: Transcriptional regulator. Recognizes and binds to the DNA sequence 5'-CGCCCCCGC-3'(EGR-site). Activates the

transcription of target genes whose products are required for mitogenesis and differentiation

Induction: By growth factors

Genatlas biochemistry entry for EGR1:

immediate early growth response,gene 1 (pAT225),nerve growth factor induced clone A,specifically expressed in Schwann

cells,induced by a wide variety of extracellular stimuli,involved in cell proliferation,macrophage

differentiation,synaptic activation and long term potentiation,coactivated by CREBBP

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		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat EGR1
		8/46 QIAGEN miScript miRNA Assays for microRNAs that regulate EGR1 (see all 46):
		hsa-miR-548j hsa-miR-24-1* hsa-miR-199a-3p hsa-miR-124 hsa-miR-548d-5p hsa-miR-548a-5p hsa-miR-506 hsa-miR-510

		SwitchGear 3'UTR luciferase reporter plasmid: EGR1 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for EGR1 (see all 7) OriGene shRNA RFP: EGR1 OriGene siRNA: EGR1
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Gene Editing
Products:

DNA2.0 Custom Protein Engineering Service for EGR1

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		GenScript: all cDNA clones in your preferred vector: EGR1 (NM_001964)
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Cell Line Products:		GenScript Custom overexpressing Cell Line Services for EGR1
		Search LifeMap BioReagents cell lines for EGR1

In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for EGR1

Gene Ontology (GO): 5/14 molecular function terms (GO ID links to tree view) (see all 14): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0000976	transcription regulatory region sequence-specific DNA binding	IDA	18718911
GO:0000979	RNA polymerase II core promoter sequence-specific DNA binding	IEA	--
GO:0000982	RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity	--	--
GO:0001077	RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription	IEA	--
GO:0003677	DNA binding	IDA	12560508

EGR1 for ontologies About GeneDecksing

1 GenomeRNAi human phenotype for EGR1:

Synthetic lethal with c-Myc af

Animal Models:
Mouse knock-outs for EGR1: Egr1^tm1Jmi Egr1^tm1The
15/17 MGI mutant phenotypes (inferred from 4 alleles) (MGI details for Egr1) (see all 17):

behavior/neurological	cardiovascular system	cellular	endocrine/exocrine gland	growth/size
hematopoietic system	homeostasis/metabolism	immune system	integument	liver/biliary system
mortality/aging	nervous system	reproductive system	respiratory system	skeleton

EGR1 for phenotypes About GeneDecksing

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways - 5/27 super-pathways (see all 27) About this table

See pathways by source

Super-pathway

contained gene-specific pathways

Immune response_IL-2 activation and signaling pathway

	Immune response IL-2 activation and signaling pathway	1.00			Immune response_IL-3 activation and signaling pathway	0.41
	Immune response_IL-2 activation and signaling pathway	1.00			Immune response IL-3 activation and signaling pathway	0.41

Development HGF signaling pathway

	Development_HGF signaling pathway	0.78			Apoptosis and survival Role of CDK5 in neuronal death and survival	0.24
	Apoptosis and survival_Role of CDK5 in neuronal death and survival	0.24			Signaling events mediated by Hepatocyte Growth Factor Receptor (c-Met)	0.23

Development_CNTF receptor signaling

	Development_Growth hormone signaling via PI3K/AKT and MAPK cascades	0.34			Development_Leptin signaling via JAK/STAT and MAPK cascades	0.25
	Development Growth hormone signaling via PI3K/AKT and MAPK cascades	0.34			Development Leptin signaling via JAK/STAT and MAPK cascades	0.25

G-protein signaling_Ras family GTPases in kinase cascades (scheme)

	Immune response Oncostatin M signaling via MAPK in human cells	0.39			Oncostatin M Signaling Pathway	0.15
	Immune response_Oncostatin M signaling via MAPK in human cells	0.39

Development_Hedgehog and PTH signaling pathways in bone and cartilage development

Development_Hedgehog and PTH signaling pathways in bone and cartilage development

1.00

Development Hedgehog and PTH signaling pathways in bone and cartilage development

0.97

Pathway sources
See GeneCards unified pathways
Show all pathways

5/10 EMD Millipore Pathways for EGR1 (see all 10)

	Development Hedgehog and PTH signaling pathways in bone and cartilage development
	Development Growth hormone signaling via PI3K/AKT and MAPK cascades
	Immune response BCR pathway
	Apoptosis and survival Role of CDK5 in neuronal death and survival
	Transcription factors in neurogenesis

1 Downloadable PowerPoint Slide of QIAGEN Pathway Central Maps for EGR1

CDK5 Pathway

1 Cell Signaling Technology (CST) Pathway for EGR1

Neuroscience

5/10 GeneGo (Thomson Reuters) Pathways for EGR1 (see all 10)

	Development Hedgehog and PTH signaling pathways in bone and cartilage development
	Development Leptin signaling via JAK/STAT and MAPK cascades
	Immune response BCR pathway
	Development ACM2 and ACM4 activation of ERK
	Immune response IL-2 activation and signaling pathway

5/16 BioSystems Pathways for EGR1 (see all 16)

	Oncostatin M Signaling Pathway
	Serotonin Receptor 4/6/7 and NR3C Signaling
	SIDS Susceptibility Pathways
	Integrated Pancreatic Cancer Pathway
	Insulin Signaling

5 Reactome Pathways for EGR1

	Interferon alpha/beta signaling
	Cytokine Signaling in Immune system
	Expression of IFN-induced genes
	Interferon Signaling
	Immune System

1 Kegg Pathway (Kegg details for EGR1):

Prion diseases

EGR1 for pathways About GeneDecksing

Interactions:

SABiosciences Gene Network Central^TM Interacting Genes and Proteins Network for EGR1

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

5/82 Interacting proteins for EGR1 (P18146^{1, 2, 3} ENSP00000239938⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 82)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
CDKN2A	Q8N726²^,³, ENSP00000355153⁴	MINT-7011792 MINT-7011820 MINT-7011781 MINT-7011806 I2D: score=1 STRING: ENSP00000355153
TP53	P04637²^,³, ENSP00000269305⁴	MINT-4793180 I2D: score=5 STRING: ENSP00000269305
EP300	Q09472²^,³, ENSP00000263253⁴	MINT-7306489 MINT-7306512 MINT-7306501 I2D: score=4 STRING: ENSP00000263253
VDR	P11473², ENSP00000229022⁴	MINT-7306489 MINT-7306512 MINT-7306501 STRING: ENSP00000229022
SUMO1	P63165²^,³, ENSP00000376076⁴	MINT-7011835 I2D: score=1 STRING: ENSP00000376076

About this table

Gene Ontology (GO): 5/45 biological process terms (GO ID links to tree view) (see all 45): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0000122	negative regulation of transcription from RNA polymerase II promoter	IEA	--
GO:0001975	response to amphetamine	IEA	--
GO:0006351	transcription, DNA-dependent	--	--
GO:0006355	regulation of transcription, DNA-dependent	--	--
GO:0006366	transcription from RNA polymerase II promoter	IDA	19057511

EGR1 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

EGR1 for compounds About GeneDecksing

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for EGR1
10/122 Novoseek chemical compound relationships for EGR1 gene (see all 122) About this table

Compound	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
zinc	66.8	120	8132543 (4), 9485332 (3), 8336701 (2), 10671503 (2) (see all 72)
pd 98,059	65.8	24	17230532 (2), 11121417 (2), 12483323 (1), 12457461 (1) (see all 22)
ptx1	55.9	4	10859489 (2), 10082522 (1), 15469090 (1)
12-o-tetradecanoylphorbol 13-acetate	54.6	37	15910736 (4), 8018558 (2), 1417981 (2), 11751871 (1) (see all 16)
nogalamycin	52.7	2	8798634 (1), 11222751 (1)
phorbol-12-myristate	48	4	7519845 (1), 11007455 (1), 15231681 (1), 10674404 (1)
sulindac sulfide	42.4	9	17599376 (4), 16079301 (2), 15509713 (1)
phosphatidylinositol	41.3	28	10050043 (4), 8302296 (2), 16424010 (2), 11403719 (2) (see all 18)
vegf	41.3	48	19526316 (7), 11149911 (5), 10339488 (4), 16103054 (4) (see all 21)
ly294002	40.4	14	16489044 (3), 18831964 (2), 15449318 (1), 17715378 (1) (see all 7)

Search CenterWatch for drugs/clinical trials and news about EGR1

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
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Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for EGR1 gene:

NM_001964.2

Unigene Clusters for EGR1:

Early growth response 1

Hs.326035 [show with all ESTs], Hs.708393 [show with all ESTs]

Unigene Representative Sequences: NM_001964, CD522629

1 Ensembl transcript including schematic representation, and UCSC links where relevant:

ENST00000239938(uc003ldb.1)

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		hsa-miR-548j hsa-miR-24-1* hsa-miR-199a-3p hsa-miR-124 hsa-miR-548d-5p hsa-miR-548a-5p hsa-miR-506 hsa-miR-510

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		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat EGR1
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat EGR1

Additional cDNA sequence: M24019.1

16 DOTS entries:

DT.451515 DT.92410441 DT.100815176 DT.92444091 DT.92444078 DT.100815174 DT.100652567 DT.100815170

DT.100838251 DT.120828084 DT.75188226 DT.92444088 DT.95168866 DT.95288077 DT.91927235 DT.95243780

24/292 AceView cDNA sequences (see all 292):

BF438983 BC073983 BM854744 BX645009 AI581640 AI741775 AI582664 BM310258

AI978658 CD236972 AI083849 AI701078 H88614 BQ447364 AA679209 AL553329

BX425480 BU198010 R83762 BQ181084 BG059835 AA398179 AL602754 BU952514

GeneLoc Exon Structure

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

EGR1 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GGATATGTGG

About this image

EGR1 expression in embryonic tissues and stem cells

Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

10/20 LifeMap In Vivo Development Anatomical Compartments/Cells (see all 20)

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Limb

Limb Bud

Limb Bud Mesenchyme Cells

Mesoderm

Tendons & Ligaments

Axial Tendon Primordia

Early Tenocyte Cells

Tendons & Ligaments

Limb Tendon Primordia

Early Tenocyte Cells

Tendons & Ligaments

Limb Tendons and Ligamnets

Tenocytes

Tendons & Ligaments

Kidney

Bowman's Capsule

Parietal Epithelial Cells

Kidney

Cap Mesenchyme

Cap Mesenchyme Cells

Kidney

Interstitial Stroma

Interstitial Stroma Cells

Kidney

S-shaped Body

S-shaped Body Cells

Kidney

Ureteric Bud

Ureteric Bud Tip Cells

Kidney

Testis

Seminiferous Tubules

Sertoli cells

Testis

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

Stem Cell Differentiation: 4 LifeMap Cells

Name

Category

PureStem™ mesenchymal progenitor 7SMOO32 (Embryonic Progenitor Cell)

Adipose, Bone, Cartilage

PureStem™ progenitor EN27 (Embryonic Progenitor Cell)

PureStem™ progenitor SK17 (Embryonic Progenitor Cell)

Secondary follicles (Primary Cell)

Ovary, Reproductive System

See EGR1 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for EGR1

SOURCE GeneReport for Unigene clusters: Hs.326035 Hs.708393

SABiosciences Expression via Pathway-Focused PCR Arrays including EGR1 (see all 19):

Multiple Sclerosis in human mouse rat

Nitric Oxide Signaling Pathway in human mouse rat

Hypoxia Signaling Pathway in human mouse rat

T-cell & B-cell Activation in human mouse rat

cAMP / Ca2+ Signaling PathwayFinder in human mouse rat

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for EGR1 Browse OriGene validated miRNA SYBR primer pairs
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		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat EGR1

In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for EGR1

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of animals.

Orthologs for EGR1 gene from 6/18 species (see all 18) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Details
mouse (Mus musculus)	Mammalia	Egr1^{1 , 5}	early growth response 1^{1, 5}	87.59(n)¹ 93.42(a)¹	18 (18.76 cM)⁵ 13653¹ NM_007913.5¹ NP_031939.1¹ 34859823⁵
chicken (Gallus gallus)	Aves	EGR1¹	early growth response 1	73.2(n) 76.04(a)	373931 NM_204136.2 NP_989467.2
African clawed frog (Xenopus laevis)	Amphibia	Xl.637²	Xenopus laevis early growth response protein mRNA, more	77.47(n)	AF250345.1
zebrafish (Danio rerio)	Actinopterygii	egr1²	early growth response 1	76.22(n)	30498 NM_131248.1
fruit fly (Drosophila melanogaster)	Insecta	sr³	tracheal cell migration (sensu Insecta) RNA polymerase more	76(a)	--
worm (Caenorhabditis elegans)	Secernentea	C27C12.2³	Zinc finger, C2H2 type (3 domains)	84(a) (best of 2)	X(14881084-14882208) --

ENSEMBL Gene Tree for EGR1 (if available)
TreeFam Gene Tree for EGR1 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
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Paralogs for EGR1 gene

EGR3² EGR4² WT1² EGR2²

2 SIMAP similar genes for EGR1 using alignment to 2 protein entries: EGR1_HUMAN (see all proteins):

EGR3 EGR2

EGR1 for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
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SNP ID	Valid	Clinical significance	Chr 5 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs76606969^1,2	F,	--	132989953(+)	`CCCTCC/ACCCAC`	1	--	us2k¹		1		WA	118
rs201538814^1,2	C	--	132989991(-)	`CCCCAA/CCAGCC`	1	--	us2k¹		0	--	--	--	--
rs77541789^1,2		--	132990231(+)	`GGAGAA/CCTGCG`	1	--	us2k¹		0	--	--	--	--
rs34620091^1,2	C,F,H,	--	132990681(+)	`CACCAC/TAAGGA`	1	--	us2k¹		10		MN NS NA	1128
rs34838824^1,2	C,F,	--	132990819(+)	`ACAGGG/AGACCC`	1	--	us2k¹		5		MN	408
rs35125460^1,2	F	--	132991017(+)	`GGCGGG/ACCCAG`	1	--	us2k¹		5		MN	408
rs1800778^1,2	C,	--	132991578(+)	`GGGCGC/TTGTCG`	1	--	us2k¹		3		MN NA	1090
rs28365161^1,2	C,F,	--	132991974(+)	`CTGCAC/G/TCCCCC`	2	--	ut5¹		1		--	22
rs6873141^1,2	C,	--	132991979(+)	`CCCCCC/GCGCCC`	1	--	ut5¹		0	--	--	--	--
rs202023911^1,2	C	--	132992039(+)	`GAGATG/ACAGCT`	2	/I /M	mis¹		1		EU	1317

HapMap Linkage Disequilibrium report for EGR1 (137801179 - 137805004 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for EGR1
1 CNV: 36348

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

EGR1 for disorders           About GeneDecksing

OMIM gene information: 128990    OMIM disorders: --

20/110 diseases for EGR1 (see all 110):    About MalaCards

normophosphatemic familial tumoral calcinosis familial tumoral calcinosis abdominal aortic aneurysm calcinosis

aortic aneurysm multiple endocrine neoplasia chronic obstructive pulmonary disease herpes simplex

absence epilepsy small cell carcinoma burkitt's lymphoma monocytic leukemia

b-cell lymphomas brain ischemia malignant glioma silicosis

prostate small cell carcinoma inflammatory breast cancer esophageal squamous cell carcinoma wilms tumor

2 diseases from the University of Copenhagen DISEASES database for EGR1:

Cancer Vascular disease

10/77 Novoseek disease relationships for EGR1 gene (see all 77) About this table

Disease	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
wilms tumor	50.9	19	11106242 (5), 20123987 (2), 7823937 (1), 11734301 (1) (see all 12)
tumors	47.6	195	9212230 (6), 15774784 (6), 19878561 (5), 16093249 (5) (see all 99)
myeloid leukemia	37.1	5	1864967 (1), 8381016 (1), 7690249 (1), 7706752 (1) (see all 5)
necrosis	36.8	32	11586099 (1), 14726502 (1), 18814180 (1), 1730654 (1) (see all 29)
monocytic leukemia	33	3	11734301 (2), 2064996 (1)
ocular dominance	31.2	3	8481787 (2), 11797318 (1)
leukemia t-cell	31.1	1	1359492 (1)
fibrosarcoma	30.9	15	8876223 (2), 9714058 (2), 11121417 (2), 7585551 (1) (see all 9)
atherosclerosis	29.2	16	19036858 (2), 10712437 (2), 17967787 (2), 11676978 (1) (see all 10)
carcinoma embryonal	29.2	6	1909429 (1), 8180132 (1), 8176254 (1), 9824160 (1) (see all 5)

Genetic Association Database (GAD): EGR1
Human Genome Epidemiology (HuGE) Navigator: EGR1 (7 documents)
Tumor Gene Database (TGDB): EGR1

Export disorders for EGR1 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for EGR1 gene, integrated from 9 sources (see all 996):
(articles sorted by number of sources associating them with EGR1)

Utopia: connect your pdf to the dynamic
world of online information

Snail associates with EGR-1 and SP-1 to upregulate tr anscriptional activation of p15INK4b. (PubMed id 20121949)^{1, 2, 9} Hu C.T....Wu W.S. (2010)
A gene coding for a zinc finger protein is induced during 12-O- tetradecanoylphorbol-13-acetate-stimulated HL-60 cell differentiation. (PubMed id 1569051)^{1, 2, 9} Shimizu N....Utiyama H. (1992)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
Expression of a zinc finger gene in HTLV-I- and HTLV-II-transformed cells. (PubMed id 2110381)^{1, 2} Wright J.J....Siebenlist U. (1990)
cDNA sequence of the human cellular early growth response gene Egr- 1. (PubMed id 2377485)^{1, 2} Suggs S.V.... Sukhatme V.P. (1990)
A zinc finger-encoding gene coregulated with c-fos during growth and differentiation, and after cellular depolarization. (PubMed id 3127059)^{1, 3} Sukhatme V.P....Curran T. (1988)
Basal EGR-1 (zif268, NGFI-A, Krox-24) expression in developing striatal patches: role of dopamine and glutamate. (PubMed id 12470865)^{1, 9} Snyder-Keller A....Mitchell E.S. (2002)
Concurrent down-regulation of Egr-1 and gelsolin in the majority of human breast cancer cells. (PubMed id 18204200)^{1, 9} Liu J....Huang R.P. (2007)
Regulation of expression of the early growth response gene-1 (EGR-1) in malignant and benign cells of the prostate. (PubMed id 15486985)^{1, 9} Mora G.R....Tindall D.J. (2005)
The egr-1 gene is induced by DNA-damaging agents and non-genotoxic drugs in both normal and neoplastic human cells. (PubMed id 12706485)^{1, 9} Quinones A....Rainov N.G. (2003)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Disorders
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 1958	HGNC: 3238	AceView: EGR1	Ensembl:ENSG00000120738	euGenes: HUgn1958
ECgene: EGR1	Kegg: 1958	H-InvDB: EGR1

(According to HUGE)
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(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for EGR1	Pharmacogenomics, SNPs, Pathways
ATLAS Chromosomes in Cancer entry for EGR1	Genetics and Cytogenetics in Oncology and Haematology

Intellectual Property for EGR1 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

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Patent Information for EGR1 gene:
Search GeneIP for patents involving EGR1

GeneCards and IP:
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early growth response 1

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