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Aliases for EGR1 Gene

Aliases for EGR1 Gene

  • Early Growth Response 1 2 3
  • Nerve Growth Factor-Induced Protein A 2 3 4
  • Transcription Factor ETR103 2 3 4
  • Zinc Finger Protein 225 2 3 4
  • Early Growth Response Protein 1 2 3
  • Transcription Factor Zif268 3 4
  • Zinc Finger Protein Krox-24 3 4
  • NGFI-A 3 4
  • ZNF225 3 4
  • AT225 3 4
  • EGR-1 3 4
  • KROX-24 3
  • ZIF-268 3
  • KROX24 4
  • G0S30 3
  • TIS8 3

External Ids for EGR1 Gene

Previous GeneCards Identifiers for EGR1 Gene

  • GC05P137675
  • GC05P138476
  • GC05P137832
  • GC05P137877
  • GC05P137829
  • GC05P137801
  • GC05P132991

Summaries for EGR1 Gene

Entrez Gene Summary for EGR1 Gene

  • The protein encoded by this gene belongs to the EGR family of C2H2-type zinc-finger proteins. It is a nuclear protein and functions as a transcriptional regulator. The products of target genes it activates are required for differentitation and mitogenesis. Studies suggest this is a cancer suppressor gene. [provided by RefSeq, Dec 2014]

GeneCards Summary for EGR1 Gene

EGR1 (Early Growth Response 1) is a Protein Coding gene. Diseases associated with EGR1 include familial tumoral calcinosis and fibrosarcoma. Among its related pathways are Integrated Pancreatic Cancer Pathway and Glucocorticoid receptor regulatory network. GO annotations related to this gene include sequence-specific DNA binding transcription factor activity and transcription factor binding. An important paralog of this gene is WT1.

UniProtKB/Swiss-Prot for EGR1 Gene

  • Transcriptional regulator. Recognizes and binds to the DNA sequence 5-CGCCCCCGC-3(EGR-site). Activates the transcription of target genes whose products are required for mitogenesis and differentiation

Gene Wiki entry for EGR1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for EGR1 Gene

Genomics for EGR1 Gene

Regulatory Elements for EGR1 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for EGR1 Gene

Start:
138,465,490 bp from pter
End:
138,469,315 bp from pter
Size:
3,826 bases
Orientation:
Plus strand

Genomic View for EGR1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for EGR1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for EGR1 Gene

Proteins for EGR1 Gene

  • Protein details for EGR1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P18146-EGR1_HUMAN
    Recommended name:
    Early growth response protein 1
    Protein Accession:
    P18146
    Secondary Accessions:

    Protein attributes for EGR1 Gene

    Size:
    543 amino acids
    Molecular mass:
    57507 Da
    Quaternary structure:
    • Interacts with SNAI1 and SP1 upon 12-O-tetradecanoylphorbol-13-acetate (TPA) induction.

    Three dimensional structures from OCA and Proteopedia for EGR1 Gene

neXtProt entry for EGR1 Gene

Proteomics data for EGR1 Gene at MOPED

Post-translational modifications for EGR1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for EGR1 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for EGR1 (EGR1)

No data available for DME Specific Peptides for EGR1 Gene

Domains for EGR1 Gene

Gene Families for EGR1 Gene

HGNC:
  • ZNF :Zinc fingers, C2H2-type

Protein Domains for EGR1 Gene

Graphical View of Domain Structure for InterPro Entry

P18146

UniProtKB/Swiss-Prot:

EGR1_HUMAN :
  • P18146
Family:
  • Belongs to the EGR C2H2-type zinc-finger protein family.
Similarity:
  • Contains 3 C2H2-type zinc fingers.
genes like me logo Genes that share domains with EGR1: view

Function for EGR1 Gene

Molecular function for EGR1 Gene

GENATLAS Biochemistry: immediate early growth response,gene 1 (pAT225),nerve growth factor induced clone A,specifically expressed in Schwann cells,induced by a wide variety of extracellular stimuli,involved in cell proliferation,macrophage differentiation,synaptic activation and long term potentiation,coactivated by CREBBP
UniProtKB/Swiss-Prot Function: Transcriptional regulator. Recognizes and binds to the DNA sequence 5-CGCCCCCGC-3(EGR-site). Activates the transcription of target genes whose products are required for mitogenesis and differentiation
UniProtKB/Swiss-Prot Induction: By growth factors

Gene Ontology (GO) - Molecular Function for EGR1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000976 transcription regulatory region sequence-specific DNA binding IDA 18718911
GO:0000977 RNA polymerase II regulatory region sequence-specific DNA binding --
GO:0000979 RNA polymerase II core promoter sequence-specific DNA binding IEA --
GO:0000982 RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity --
GO:0001077 RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription IEA --
genes like me logo Genes that share ontologies with EGR1: view
genes like me logo Genes that share phenotypes with EGR1: view

Animal Models for EGR1 Gene

MGI Knock Outs for EGR1:

Animal Model Products

CRISPR Products

miRNA for EGR1 Gene

Transcription Factor Targeting for EGR1 Gene

Selected GeneGlobe predicted Target genes for EGR1
Targeting motifs for EGR1 Gene
HOMER Transcription Factor Regulatory Elements motif EGR1
  • Consensus sequence: TGCGTGGGYG Submotif: canonical Cell Type: K562 GeoId: GSE32465

miRNA Products

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) for EGR1 Gene

Localization for EGR1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for EGR1 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for EGR1 Gene COMPARTMENTS Subcellular localization image for EGR1 gene
Compartment Confidence
nucleus 5
cytoskeleton 2
extracellular 2
plasma membrane 2
endoplasmic reticulum 1

Gene Ontology (GO) - Cellular Components for EGR1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus ISS --
GO:0005654 nucleoplasm TAS --
GO:0005737 cytoplasm ISS --
genes like me logo Genes that share ontologies with EGR1: view

Pathways for EGR1 Gene

genes like me logo Genes that share pathways with EGR1: view

PCR Array Products

Gene Ontology (GO) - Biological Process for EGR1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000122 negative regulation of transcription from RNA polymerase II promoter IEA --
GO:0001975 response to amphetamine IEA --
GO:0006355 regulation of transcription, DNA-templated --
GO:0006366 transcription from RNA polymerase II promoter IDA 19057511
GO:0007611 learning or memory IEA --
genes like me logo Genes that share ontologies with EGR1: view

Compounds for EGR1 Gene

(122) Novoseek inferred chemical compound relationships for EGR1 Gene

Compound -log(P) Hits PubMed IDs
zinc 66.8 90
pd 98,059 65.8 24
ptx1 55.9 4
12-o-tetradecanoylphorbol 13-acetate 54.6 21
nogalamycin 52.7 2
genes like me logo Genes that share compounds with EGR1: view

Transcripts for EGR1 Gene

mRNA/cDNA for EGR1 Gene

(292) Selected AceView cDNA sequences:
(8) Additional mRNA sequences :
(1) REFSEQ mRNAs :
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for EGR1 Gene

Early growth response 1:
Representative Sequences:

CRISPR Products

miRNA Products

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for EGR1 Gene

No ASD Table

Relevant External Links for EGR1 Gene

GeneLoc Exon Structure for
EGR1
ECgene alternative splicing isoforms for
EGR1

Expression for EGR1 Gene

mRNA expression in normal human tissues for EGR1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for EGR1 Gene

This gene is overexpressed in Fallopian Tube (9.0) and Adipose - Visceral (Omentum) (4.2).

SOURCE GeneReport for Unigene cluster for EGR1 Gene Hs.326035

genes like me logo Genes that share expressions with EGR1: view

In Situ Assay Products

No data available for Protein expression and mRNA Expression by UniProt/SwissProt for EGR1 Gene

Orthologs for EGR1 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for EGR1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia EGR1 35
  • 98.11 (n)
  • 97.46 (a)
cow
(Bos Taurus)
Mammalia EGR1 35
  • 89.67 (n)
  • 92.02 (a)
EGR1 36
  • 94 (a)
OneToOne
dog
(Canis familiaris)
Mammalia EGR1 35
  • 89.59 (n)
  • 92.98 (a)
EGR1 36
  • 94 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Egr1 35
  • 86.77 (n)
  • 91.87 (a)
Egr1 16
Egr1 36
  • 93 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Egr1 35
  • 86.13 (n)
  • 91.12 (a)
chicken
(Gallus gallus)
Aves EGR1 35
  • 72.74 (n)
  • 75.25 (a)
EGR1 36
  • 75 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.637 35
tropical clawed frog
(Silurana tropicalis)
Amphibia egr1 35
  • 71.51 (n)
  • 76.21 (a)
Str.19374 35
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.9236 35
zebrafish
(Danio rerio)
Actinopterygii egr1 35
  • 69.1 (n)
  • 66.53 (a)
egr1 36
  • 64 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta sr 36
  • 12 (a)
OneToMany
sr 37
  • 76 (a)
worm
(Caenorhabditis elegans)
Secernentea egrh-3 36
  • 24 (a)
ManyToMany
Y55F3AM.7 37
  • 64 (a)
C27C12.2 37
  • 84 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes MIG2 36
  • 14 (a)
ManyToMany
MIG3 36
  • 14 (a)
ManyToMany
Species with no ortholog for EGR1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for EGR1 Gene

ENSEMBL:
Gene Tree for EGR1 (if available)
TreeFam:
Gene Tree for EGR1 (if available)

Paralogs for EGR1 Gene

Paralogs for EGR1 Gene

Selected SIMAP similar genes for EGR1 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with EGR1: view

Variants for EGR1 Gene

Sequence variations from dbSNP and Humsavar for EGR1 Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type MAF
rs6914 -- 138,468,946(+) ATGAT(A/C/T)TGGGG utr-variant-3-prime
rs1042086 -- 138,465,688(+) GCAAC(G/T)GTGTC utr-variant-5-prime
rs1042088 -- 138,467,421(+) AAGTA(C/T)CCCAA reference, synonymous-codon
rs1042197 -- 138,468,598(+) AAAAA(A/G)AAAAG utr-variant-3-prime
rs1800778 -- 138,465,324(+) GGGCG(C/T)TGTCG upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for EGR1 Gene

Variant ID Type Subtype PubMed ID
nsv5024 CNV Insertion 18451855
nsv528851 CNV Loss 19592680
nsv5025 CNV Loss 18451855

Relevant External Links for EGR1 Gene

HapMap Linkage Disequilibrium report
EGR1
Human Gene Mutation Database (HGMD)
EGR1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for EGR1 Gene

Disorders for EGR1 Gene

MalaCards: The human disease database

MalaCards: The human disease database. (3) Diseases for EGR1 Gene including...

Search for EGR1 Gene in MalaCards »

(2) University of Copenhagen DISEASES for EGR1 Gene

(77) Novoseek inferred disease relationships for EGR1 Gene

Disease -log(P) Hits PubMed IDs
wilms tumor 50.9 17
tumors 47.6 143
myeloid leukemia 37.1 5
necrosis 36.8 29
monocytic leukemia 33 3

Relevant External Links for EGR1

Genetic Association Database (GAD)
EGR1
Human Genome Epidemiology (HuGE) Navigator
EGR1
Tumor Gene Database (TGDB):
EGR1
genes like me logo Genes that share disorders with EGR1: view

No data available for UniProtKB/Swiss-Prot for EGR1 Gene

Publications for EGR1 Gene

  1. A gene coding for a zinc finger protein is induced during 12-O- tetradecanoylphorbol-13-acetate-stimulated HL-60 cell differentiation. (PMID: 1569051) Shimizu N. … Utiyama H. (J. Biochem. 1992) 3 4 23
  2. Association of early growth response-1 gene polymorphisms with total IgE and atopy in asthmatic children. (PMID: 18507785) Chan I.H. … Lam C.W. (Pediatr Allergy Immunol 2009) 3 23 48
  3. Aryl hydrocarbon receptor is activated by glucose and regulates the thrombospondin-1 gene promoter in endothelial cells. (PMID: 18515748) Dabir P. … Stenina O.I. (Circ. Res. 2008) 3 23
  4. Egr-1 abrogates the E2F-1 block in terminal myeloid differentiation and suppresses leukemia. (PMID: 17599039) Gibbs J.D. … Hoffman B. (Oncogene 2008) 3 23
  5. Transcriptional regulation of EGR-1 by the interleukin-1-JNK-MKK7-c-Jun pathway. (PMID: 18281687) Hoffmann E. … Kracht M. (J. Biol. Chem. 2008) 3 23

Products for EGR1 Gene

  • Addgene plasmids for EGR1

Sources for EGR1 Gene

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