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Aliases for EGR1 Gene

Aliases for EGR1 Gene

  • Early Growth Response 1 2 3 5
  • Nerve Growth Factor-Induced Protein A 2 3 4
  • Transcription Factor ETR103 2 3 4
  • Zinc Finger Protein 225 2 3 4
  • Transcription Factor Zif268 3 4
  • Zinc Finger Protein Krox-24 3 4
  • NGFI-A 3 4
  • ZNF225 3 4
  • AT225 3 4
  • EGR-1 3 4
  • Early Growth Response Protein 1 2
  • KROX-24 3
  • ZIF-268 3
  • KROX24 4
  • G0S30 3
  • TIS8 3

External Ids for EGR1 Gene

Previous GeneCards Identifiers for EGR1 Gene

  • GC05P137675
  • GC05P138476
  • GC05P137832
  • GC05P137877
  • GC05P137829
  • GC05P137801
  • GC05P132991

Summaries for EGR1 Gene

Entrez Gene Summary for EGR1 Gene

  • The protein encoded by this gene belongs to the EGR family of C2H2-type zinc-finger proteins. It is a nuclear protein and functions as a transcriptional regulator. The products of target genes it activates are required for differentitation and mitogenesis. Studies suggest this is a cancer suppressor gene. [provided by RefSeq, Dec 2014]

GeneCards Summary for EGR1 Gene

EGR1 (Early Growth Response 1) is a Protein Coding gene. Diseases associated with EGR1 include Familial Tumoral Calcinosis and Monocytic Leukemia. Among its related pathways are HTLV-I infection and Trk receptor signaling mediated by PI3K and PLC-gamma. GO annotations related to this gene include transcription factor activity, sequence-specific DNA binding and transcription factor binding. An important paralog of this gene is EGR4.

UniProtKB/Swiss-Prot for EGR1 Gene

  • Transcriptional regulator. Recognizes and binds to the DNA sequence 5-CGCCCCCGC-3(EGR-site). Activates the transcription of target genes whose products are required for mitogenesis and differentiation.

Gene Wiki entry for EGR1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for EGR1 Gene

Genomics for EGR1 Gene

Regulatory Elements for EGR1 Gene

Enhancers for EGR1 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around EGR1 on UCSC Golden Path with GeneCards custom track

Promoters for EGR1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around EGR1 on UCSC Golden Path with GeneCards custom track

Genomic Location for EGR1 Gene

Chromosome:
5
Start:
138,465,490 bp from pter
End:
138,469,315 bp from pter
Size:
3,826 bases
Orientation:
Plus strand

Genomic View for EGR1 Gene

Genes around EGR1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
EGR1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for EGR1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for EGR1 Gene

Proteins for EGR1 Gene

  • Protein details for EGR1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P18146-EGR1_HUMAN
    Recommended name:
    Early growth response protein 1
    Protein Accession:
    P18146

    Protein attributes for EGR1 Gene

    Size:
    543 amino acids
    Molecular mass:
    57507 Da
    Quaternary structure:
    • Interacts with SNAI1 and SP1 upon 12-O-tetradecanoylphorbol-13-acetate (TPA) induction.

    Three dimensional structures from OCA and Proteopedia for EGR1 Gene

neXtProt entry for EGR1 Gene

Proteomics data for EGR1 Gene at MOPED

Post-translational modifications for EGR1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for EGR1 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for EGR1 (EGR1)

No data available for DME Specific Peptides for EGR1 Gene

Domains & Families for EGR1 Gene

Gene Families for EGR1 Gene

Protein Domains for EGR1 Gene

Graphical View of Domain Structure for InterPro Entry

P18146

UniProtKB/Swiss-Prot:

EGR1_HUMAN :
  • Belongs to the EGR C2H2-type zinc-finger protein family.
  • Contains 3 C2H2-type zinc fingers.
Family:
  • Belongs to the EGR C2H2-type zinc-finger protein family.
Similarity:
  • Contains 3 C2H2-type zinc fingers.
genes like me logo Genes that share domains with EGR1: view

Function for EGR1 Gene

Molecular function for EGR1 Gene

GENATLAS Biochemistry:
immediate early growth response,gene 1 (pAT225),nerve growth factor induced clone A,specifically expressed in Schwann cells,induced by a wide variety of extracellular stimuli,involved in cell proliferation,macrophage differentiation,synaptic activation and long term potentiation,coactivated by CREBBP
UniProtKB/Swiss-Prot Function:
Transcriptional regulator. Recognizes and binds to the DNA sequence 5-CGCCCCCGC-3(EGR-site). Activates the transcription of target genes whose products are required for mitogenesis and differentiation.
UniProtKB/Swiss-Prot Induction:
By growth factors.

Gene Ontology (GO) - Molecular Function for EGR1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000977 RNA polymerase II regulatory region sequence-specific DNA binding IEA,IDA 14979875
GO:0000982 transcription factor activity, RNA polymerase II core promoter proximal region sequence-specific binding IEA --
GO:0005515 protein binding IPI 19057511
genes like me logo Genes that share ontologies with EGR1: view
genes like me logo Genes that share phenotypes with EGR1: view

Animal Models for EGR1 Gene

MGI Knock Outs for EGR1:

Animal Model Products

  • Taconic Biosciences Mouse Models for EGR1

Transcription Factor Targets for EGR1 Gene

Selected GeneGlobe predicted Target genes for EGR1
Targeted motifs for EGR1 Gene
HOMER Transcription Factor Regulatory Elements motif EGR1
  • Consensus sequence: TGCGTGGGYG Submotif: canonical Cell Type: K562 GEO ID: GSE32465

No data available for Enzyme Numbers (IUBMB) and Human Phenotype Ontology for EGR1 Gene

Localization for EGR1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for EGR1 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for EGR1 Gene COMPARTMENTS Subcellular localization image for EGR1 gene
Compartment Confidence
nucleus 5
cytoskeleton 2
cytosol 2
extracellular 2
mitochondrion 2
plasma membrane 2
endoplasmic reticulum 1
peroxisome 1

No data available for Gene Ontology (GO) - Cellular Components for EGR1 Gene

Pathways & Interactions for EGR1 Gene

genes like me logo Genes that share pathways with EGR1: view

SIGNOR curated interactions for EGR1 Gene

Is activated by:

Gene Ontology (GO) - Biological Process for EGR1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006366 transcription from RNA polymerase II promoter IDA 19057511
GO:0019221 cytokine-mediated signaling pathway TAS --
GO:0030217 T cell differentiation IEA --
GO:0030509 BMP signaling pathway IEA --
GO:0032868 response to insulin IEA --
genes like me logo Genes that share ontologies with EGR1: view

Drugs & Compounds for EGR1 Gene

(68) Drugs for EGR1 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(54) Additional Compounds for EGR1 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with EGR1: view

Transcripts for EGR1 Gene

mRNA/cDNA for EGR1 Gene

(1) REFSEQ mRNAs :
(8) Additional mRNA sequences :
(292) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for EGR1 Gene

Early growth response 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for EGR1 Gene

No ASD Table

Relevant External Links for EGR1 Gene

GeneLoc Exon Structure for
EGR1
ECgene alternative splicing isoforms for
EGR1

Expression for EGR1 Gene

mRNA expression in normal human tissues for EGR1 Gene

mRNA differential expression in normal tissues according to GTEx for EGR1 Gene

This gene is overexpressed in Fallopian Tube (x9.0) and Adipose - Visceral (Omentum) (x4.2).

SOURCE GeneReport for Unigene cluster for EGR1 Gene Hs.326035

genes like me logo Genes that share expression patterns with EGR1: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for EGR1 Gene

Orthologs for EGR1 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for EGR1 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia EGR1 35
  • 89.67 (n)
  • 92.02 (a)
EGR1 36
  • 94 (a)
OneToOne
dog
(Canis familiaris)
Mammalia EGR1 35
  • 89.59 (n)
  • 92.98 (a)
EGR1 36
  • 94 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Egr1 35
  • 86.77 (n)
  • 91.87 (a)
Egr1 16
Egr1 36
  • 93 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia EGR1 35
  • 98.11 (n)
  • 97.46 (a)
rat
(Rattus norvegicus)
Mammalia Egr1 35
  • 86.13 (n)
  • 91.12 (a)
chicken
(Gallus gallus)
Aves EGR1 35
  • 72.74 (n)
  • 75.25 (a)
EGR1 36
  • 75 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia egr1 35
  • 71.51 (n)
  • 76.21 (a)
Str.19374 35
African clawed frog
(Xenopus laevis)
Amphibia Xl.637 35
zebrafish
(Danio rerio)
Actinopterygii egr1 35
  • 69.1 (n)
  • 66.53 (a)
egr1 36
  • 64 (a)
OneToOne
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.9236 35
fruit fly
(Drosophila melanogaster)
Insecta sr 37
  • 76 (a)
sr 36
  • 12 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea C27C12.2 37
  • 84 (a)
Y55F3AM.7 37
  • 64 (a)
egrh-3 36
  • 24 (a)
ManyToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes MIG2 36
  • 14 (a)
ManyToMany
MIG3 36
  • 14 (a)
ManyToMany
Species with no ortholog for EGR1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for EGR1 Gene

ENSEMBL:
Gene Tree for EGR1 (if available)
TreeFam:
Gene Tree for EGR1 (if available)

Paralogs for EGR1 Gene

Paralogs for EGR1 Gene

(2) SIMAP similar genes for EGR1 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with EGR1: view

Variants for EGR1 Gene

Sequence variations from dbSNP and Humsavar for EGR1 Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type
rs28365166 - 138,466,881(+) CCCAA(A/C)AGTGG reference, missense
rs28365164 - 138,466,884(+) AACAG(G/T)GGCAA reference, missense
rs28365165 - 138,467,106(+) CCTGA(G/T)CCACA reference, missense
rs13181973 - 138,465,844(+) GCCCA(C/T)CATGG reference, missense
rs6914 -- 138,468,946(+) ATGAT(A/C/T)TGGGG utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for EGR1 Gene

Variant ID Type Subtype PubMed ID
nsv5024 CNV Insertion 18451855
nsv528851 CNV Loss 19592680
nsv5025 CNV Loss 18451855

Variation tolerance for EGR1 Gene

Residual Variation Intolerance Score: 9.66% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.49; 29.02% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for EGR1 Gene

Human Gene Mutation Database (HGMD)
EGR1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for EGR1 Gene

Disorders for EGR1 Gene

MalaCards: The human disease database

(10) MalaCards diseases for EGR1 Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
familial tumoral calcinosis
monocytic leukemia
  • schilling's leukemia
wilms tumor susceptibility-5
  • wilms tumor
chlamydia
  • chlamydia trachomatis infectious disease
chemical colitis
- elite association - COSMIC cancer census association via MalaCards
Search EGR1 in MalaCards View complete list of genes associated with diseases

Relevant External Links for EGR1

Genetic Association Database (GAD)
EGR1
Human Genome Epidemiology (HuGE) Navigator
EGR1
Tumor Gene Database (TGDB):
EGR1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
EGR1
genes like me logo Genes that share disorders with EGR1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for EGR1 Gene

Publications for EGR1 Gene

  1. Snail associates with EGR-1 and SP-1 to upregulate transcriptional activation of p15INK4b. (PMID: 20121949) Hu C.T. … Wu W.S. (FEBS J. 2010) 3 4 67
  2. Downregulation of stathmin expression is mediated directly by Egr1 and associated with p53 activity in lung cancer cell line A549. (PMID: 19786090) Fang L. … Huizhong Z. (Cell. Signal. 2010) 3 23
  3. Phosphorylation and acetylation of histone H3 and autoregulation by early growth response 1 mediate interleukin 1beta induction of early growth response 1 transcription. (PMID: 20018936) Wang B. … Khachigian L.M. (Arterioscler. Thromb. Vasc. Biol. 2010) 3 23
  4. 15(S)-hydroxyeicosatetraenoic acid-induced angiogenesis requires Src-mediated Egr-1-dependent rapid induction of FGF-2 expression. (PMID: 20053757) Kundumani-Sridharan V. … Rao G.N. (Blood 2010) 3 23
  5. The effect of siRNA-Egr-1 and camptothecin on growth and chemosensitivity of breast cancer cell lines. (PMID: 20204305) Parra E. … Ferreira J. (Oncol. Rep. 2010) 3 23

Products for EGR1 Gene

Sources for EGR1 Gene

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