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EGR1 Gene

protein-coding   GIFtS: 69
GCID: GC05P137801

Early Growth Response 1

Microbiology & Infectious Diseases Congress
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Early Growth Response 11 2     EGR-12 3
Nerve Growth Factor-Induced Protein A1 2 3     NGFI-A2 3
Transcription Factor ETR1031 2 3     ZNF2252 3
Zinc Finger Protein 2251 2 3     G0S302
Early Growth Response Protein 11 2     KROX-242
Transcription Factor Zif2682 3     TIS82
Zinc Finger Protein Krox-242 3     ZIF-2682
AT2252 3     KROX243

External Ids:    HGNC: 32381   Entrez Gene: 19582   Ensembl: ENSG000001207387   OMIM: 1289905   UniProtKB: P181463   

Export aliases for EGR1 gene to outside databases

Previous GC identifers: GC05P137675 GC05P138476 GC05P137832 GC05P137877 GC05P137829 GC05P132991


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for EGR1 Gene:
The protein encoded by this gene belongs to the EGR family of C2H2-type zinc-finger proteins. It is a nuclear
protein and functions as a transcriptional regulator. The products of target genes it activates are required for
differentitation and mitogenesis. Studies suggest this is a cancer suppresor gene. (provided by RefSeq, Jul 2008)

GeneCards Summary for EGR1 Gene:
EGR1 (early growth response 1) is a protein-coding gene. Diseases associated with EGR1 include normophosphatemic familial tumoral calcinosis, and familial tumoral calcinosis. GO annotations related to this gene include transcription factor binding and sequence-specific DNA binding transcription factor activity. An important paralog of this gene is EGR3.

UniProtKB/Swiss-Prot: EGR1_HUMAN, P18146
Function: Transcriptional regulator. Recognizes and binds to the DNA sequence 5'-CGCCCCCGC-3'(EGR-site). Activates
the transcription of target genes whose products are required for mitogenesis and differentiation

Gene Wiki entry for EGR1 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000005.10  NC_018916.2  NT_034772.7  
Regulatory elements:
   Regulatory transcription factor binding sites in the EGR1 gene promoter:
         GR   CREB   GR-beta   deltaCREB   GR-alpha   c-Ets-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): EGR1 promoter sequence
   Search Chromatin IP Primers for EGR1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat EGR1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 5q31.1   Ensembl cytogenetic band:  5q31.2   HGNC cytogenetic band: 5q23-q31

EGR1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
EGR1 gene location

GeneLoc information about chromosome 5         GeneLoc Exon Structure

GeneLoc location for GC05P137801:  view genomic region     (about GC identifiers)

Start:
137,801,179 bp from pter      End:
137,805,004 bp from pter
Size:
3,826 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: EGR1_HUMAN, P18146 (See protein sequence)
Recommended Name: Early growth response protein 1  
Size: 543 amino acids; 57507 Da
Subunit: Interacts with SNAI1 and SP1 upon 12-O-tetradecanoylphorbol-13-acetate (TPA) induction

Explore the universe of human proteins at neXtProt for EGR1: NX_P18146

Explore proteomics data for EGR1 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See EGR1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_001955.1  
    ENSEMBL proteins: 
     ENSP00000239938  
    Reactome Protein details: P18146

    EGR1 Human Recombinant Protein Products:

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    Cloud-Clone Corp. Proteins for EGR1

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    EGR1 Assay Products:

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    Cloud-Clone Corp. ELISAs for EGR1
    Cloud-Clone Corp. CLIAs for EGR1


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    ZNF: Zinc fingers, C2H2-type

    5 InterPro protein domains:
     IPR015880 Znf_C2H2-like
     IPR021839 DUF3432
     IPR013087 Znf_C2H2/integrase_DNA-bd
     IPR007087 Znf_C2H2
     IPR021849 DUF3446

    Graphical View of Domain Structure for InterPro Entry P18146

    ProtoNet protein and cluster: P18146

    1 Blocks protein domain: IPB007086 C2H2-type zinc finger signature

    UniProtKB/Swiss-Prot: EGR1_HUMAN, P18146
    Similarity: Belongs to the EGR C2H2-type zinc-finger protein family
    Similarity: Contains 3 C2H2-type zinc fingers


    EGR1 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: EGR1_HUMAN, P18146
    Function: Transcriptional regulator. Recognizes and binds to the DNA sequence 5'-CGCCCCCGC-3'(EGR-site). Activates
    the transcription of target genes whose products are required for mitogenesis and differentiation
    Induction: By growth factors

         Genatlas biochemistry entry for EGR1:
    immediate early growth response,gene 1 (pAT225),nerve growth factor induced clone A,specifically expressed in
    Schwann cells,induced by a wide variety of extracellular stimuli,involved in cell proliferation,macrophage
    differentiation,synaptic activation and long term potentiation,coactivated by CREBBP

         Gene Ontology (GO): Selected molecular function terms (see all 14):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000976transcription regulatory region sequence-specific DNA binding IDA18718911
    GO:0000977RNA polymerase II regulatory region sequence-specific DNA binding ----
    GO:0000979RNA polymerase II core promoter sequence-specific DNA binding IEA--
    GO:0000982RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity ----
    GO:0001077RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription IEA--
         
    EGR1 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for EGR1:
     Synthetic lethal with c-Myc af 

         Selected MGI mutant phenotypes (inferred from 4 alleles(MGI details for Egr1) (see all 17):
     behavior/neurological  cardiovascular system  cellular  endocrine/exocrine gland  growth/size/body 
     hematopoietic system  homeostasis/metabolism  immune system  integument  liver/biliary system 
     mortality/aging  nervous system  reproductive system  respiratory system  skeleton 

    EGR1 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-outs for EGR1: Egr1tm1Jmi Egr1tm1The

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for EGR1
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for EGR1

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for EGR1
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for EGR1

    Transcription Factor Targeting: 
    Selected GeneGlobe predicted Target genes for EGR1 (see all 236):
    ABHD12,  ABTB2,  ACHE,  ACTR1B,  AKR1B10,  ALKBH2,  ALMS1,  ALOX5,  AMBP,  AMMECR1L

    Targeting motifs: HOMER Transcription Factor Regulatory Elements motif viewer 
                                          Consensus sequence:  TGCGTGGGYG 

    miRNA
    Products:
        
    miRTarBase miRNAs that target EGR1:
    hsa-mir-124-3p (MIRT023192), hsa-mir-192-5p (MIRT004130), hsa-mir-183-5p (MIRT006540), hsa-mir-215-5p (MIRT024271)

    Block miRNA regulation of human, mouse, rat EGR1 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate EGR1 (see all 46):
    hsa-miR-548j hsa-miR-24-1* hsa-miR-199a-3p hsa-miR-124 hsa-miR-548d-5p hsa-miR-548a-5p hsa-miR-506 hsa-miR-510
    SwitchGear 3'UTR luciferase reporter plasmidEGR1 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for EGR1
    Predesigned siRNA for gene silencing in human, mouse, rat EGR1

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for EGR1

    Clone
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    OriGene clones in human, mouse for EGR1 (see all 7)
    OriGene ORF clones in mouse, rat for EGR1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: EGR1 (NM_001964)
    Sino Biological Human cDNA Clone for EGR1
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for EGR1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat EGR1

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    Browse ESI BIO Cell Lines and PureStem Progenitors for EGR1 
    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for EGR1


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    EGR1_HUMAN, P18146: Nucleus
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    cytoskeleton2
    extracellular2
    plasma membrane2
    endoplasmic reticulum1

    Gene Ontology (GO): 4 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus ISS--
    GO:0005654nucleoplasm TAS--
    GO:0005730NOT nucleolus IDA--
    GO:0005737cytoplasm ISS--

    EGR1 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for EGR1 About   (see all 31)                                                                                              See pathways by source

    SuperPathContained pathways About
    1G protein signaling Ras family GTPases in kinase cascades scheme
    Immune response Oncostatin M signaling via MAPK in human cells0.39
    Oncostatin M Signaling Pathway0.37
    2Interferon Signaling
    Interferon Signaling0.59
    Cytokine Signaling in Immune system0.59
    3Immune response IL 2 activation and signaling pathway
    Immune response IL 2 activation and signaling pathway0.41
    Immune response IL 3 activation and signaling pathway0.41
    4Development Angiotensin activation of ERK
    Development ACM2 and ACM4 activation of ERK0.74
    5Immune response IFN alpha beta signaling pathway
    Interferon alpha/beta signaling0.43

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 Downloadable PowerPoint Slide of GeneGlobe Pathway Central Maps for EGR1
        CDK5 Pathway

    1 Cell Signaling Technology (CST) Pathway for EGR1
        Neuroscience

    Selected GeneGo (Thomson Reuters) Pathways for EGR1 (see all 10)
        Development Hedgehog and PTH signaling pathways in bone and cartilage development
    Development Leptin signaling via JAK/STAT and MAPK cascades
    Immune response BCR pathway
    Development ACM2 and ACM4 activation of ERK
    Immune response IL-2 activation and signaling pathway

    Selected BioSystems Pathways for EGR1 (see all 17)
        Insulin Signaling
    Serotonin Receptor 4/6/7 and NR3C Signaling
    SIDS Susceptibility Pathways
    Oncostatin M Signaling Pathway
    BDNF signaling pathway


    1 Reactome Pathway for EGR1
        Interferon alpha/beta signaling


    2 Kegg Pathways  (Kegg details for EGR1):
        Prion diseases
    HTLV-I infection


    EGR1 for pathways           About GeneDecksing

        Pathway & Disease-focused RT2 Profiler PCR Arrays including EGR1 (see all 19): 
              Multiple Sclerosis in human mouse rat
              Nitric Oxide Signaling Pathway in human mouse rat
              Hypoxia Signaling Pathway in human mouse rat
              T-cell & B-cell Activation in human mouse rat
              cAMP / Ca2+ Signaling PathwayFinder in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for EGR1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for EGR1 (P181461, 2, 3 ENSP000002399384) via UniProtKB, MINT, STRING, and/or I2D (see all 90)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CDKN2AQ8N7261, 2, 3, ENSP000003551534EBI-2834611,EBI-625922 MINT-7011792 MINT-7011820 MINT-7011781 MINT-7011806 I2D: score=1 STRING: ENSP00000355153
    TP53P046372, 3, ENSP000002693054MINT-4793180 I2D: score=5 STRING: ENSP00000269305
    EP300Q094722, 3, ENSP000002632534MINT-7306489 MINT-7306512 MINT-7306501 I2D: score=4 STRING: ENSP00000263253
    VDRP114732, ENSP000002290224MINT-7306489 MINT-7306512 MINT-7306501 STRING: ENSP00000229022
    SUMO1P631652, 3, ENSP000003760764MINT-7011835 I2D: score=1 STRING: ENSP00000376076
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 52):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000122negative regulation of transcription from RNA polymerase II promoter IEA--
    GO:0001975response to amphetamine IEA--
    GO:0006355regulation of transcription, DNA-templated ----
    GO:0006366transcription from RNA polymerase II promoter IDA19057511
    GO:0007611learning or memory IEA--

    EGR1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for EGR1

    Selected Novoseek inferred chemical compound relationships for EGR1 gene (see all 122)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    zinc 66.8 120 8132543 (4), 9485332 (3), 8336701 (2), 10671503 (2) (see all 72)
    pd 98,059 65.8 24 17230532 (2), 11121417 (2), 12483323 (1), 12457461 (1) (see all 22)
    ptx1 55.9 4 10859489 (2), 10082522 (1), 15469090 (1)
    12-o-tetradecanoylphorbol 13-acetate 54.6 37 15910736 (4), 8018558 (2), 1417981 (2), 11751871 (1) (see all 16)
    nogalamycin 52.7 2 8798634 (1), 11222751 (1)
    phorbol-12-myristate 48 4 7519845 (1), 11007455 (1), 15231681 (1), 10674404 (1)
    sulindac sulfide 42.4 9 17599376 (4), 16079301 (2), 15509713 (1)
    phosphatidylinositol 41.3 28 10050043 (4), 8302296 (2), 16424010 (2), 11403719 (2) (see all 18)
    vegf 41.3 48 19526316 (7), 11149911 (5), 10339488 (4), 16103054 (4) (see all 21)
    ly294002 40.4 14 16489044 (3), 18831964 (2), 15449318 (1), 17715378 (1) (see all 7)



    EGR1 for compounds           About GeneDecksing



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for EGR1 gene: 
    NM_001964.2  

    Unigene Cluster for EGR1:

    Early growth response 1
    Hs.326035  [show with all ESTs]
    Unigene Representative Sequence: NM_001964
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000239938(uc003ldb.1)
    Congresses - knowledge worth sharing:
    European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

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    Selected qRT-PCR Assays for microRNAs that regulate EGR1 (see all 46):
    hsa-miR-548j hsa-miR-24-1* hsa-miR-199a-3p hsa-miR-124 hsa-miR-548d-5p hsa-miR-548a-5p hsa-miR-506 hsa-miR-510
    SwitchGear 3'UTR luciferase reporter plasmidEGR1 3' UTR sequence
    Inhib. RNA
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    OriGene RNAi products in human, mouse, rat for EGR1
    Predesigned siRNA for gene silencing in human, mouse, rat EGR1
    Clone
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    OriGene clones in human, mouse for EGR1 (see all 7)
    OriGene ORF clones in mouse, rat for EGR1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: EGR1 (NM_001964)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for EGR1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat EGR1
    Primer
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    OriGene qPCR primer pairs and template standards for EGR1
    OriGene qSTAR qPCR primer pairs in human, mouse for EGR1
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat EGR1
      QuantiTect SYBR Green Assays in human, mouse, rat EGR1
      QuantiFast Probe-based Assays in human, mouse, rat EGR1

    Additional mRNA sequence: 

    AK298101.1 AK301065.1 BC041701.1 BC073983.1 M62829.1 M80583.1 X52541.1 

    13 DOTS entries:

    DT.451515  DT.92410441  DT.92444091  DT.100815176  DT.92444078  DT.100815174  DT.100652567  DT.100815170 
    DT.100838251  DT.120828084  DT.75188226  DT.95288077  DT.95243780 

    Selected AceView cDNA sequences (see all 292):

    AL602754 M62829 AI625815 N22267 AI479169 AA366121 D57841 CK905255 
    AI480152 BQ447364 H88614 BX645009 AA327475 NM_001964 CA435715 CK905254 
    AI906043 BF765441 BF438983 AI581640 AA300268 M80583 AI741775 BQ181084 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    EGR1 expression in normal human tissues (normalized intensities)      EGR1 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GGATATGTGG
    EGR1 Expression
    About this image


    EGR1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 26) fully expand
     
     Kidney (Urinary System)    fully expand to see all 12 entries
             Ureteric Bud Tip Cells Ureteric Bud
             Metanephros
     
     Tooth (Integumentary System)    fully expand to see all 8 entries
             Odontoblasts Dentin
             Dentin
     
     Epithelial Cells
             Early Ameloblasts Dental Enamel
     
     Brain (Nervous System)    fully expand to see all 2 entries
             Adult Dopaminergic Neurons Ventral Tegmental Area
             Cerebellum
     
     Tendon & Ligament (Muscoskeletal System)    fully expand to see all 2 entries
             Early Tenocyte Cells Limb Tendon Primordia
    EGR1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    EGR1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.326035
        Pathway & Disease-focused RT2 Profiler PCR Arrays including EGR1 (see all 19): 
              Multiple Sclerosis in human mouse rat
              Nitric Oxide Signaling Pathway in human mouse rat
              Hypoxia Signaling Pathway in human mouse rat
              T-cell & B-cell Activation in human mouse rat
              cAMP / Ca2+ Signaling PathwayFinder in human mouse rat

    Primer
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    OriGene qPCR primer pairs and template standards for EGR1
    OriGene qSTAR qPCR primer pairs in human, mouse for EGR1
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat EGR1
    QuantiTect SYBR Green Assays in human, mouse, rat EGR1
    QuantiFast Probe-based Assays in human, mouse, rat EGR1
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for EGR1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals and fungi.

    Orthologs for EGR1 gene from Selected species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Egr11 , 5 early growth response 11, 5 86.77(n)1
    91.87(a)1
      18 (18.76 cM)5
    136531  NM_007913.51  NP_031939.11 
     348598235 
    chicken
    (Gallus gallus)
    Aves EGR11 early growth response 1 72.74(n)
    75.25(a)
      373931  NM_204136.2  NP_989467.2 
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.6372 Xenopus laevis early growth response protein mRNA, more 77.47(n)    AF250345.1 
    zebrafish
    (Danio rerio)
    Actinopterygii egr12 early growth response 1 76.22(n)   30498  NM_131248.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta sr3 tracheal cell migration (sensu Insecta)
    RNA polymerase more
    76(a)     --
    worm
    (Caenorhabditis elegans)
    Secernentea C27C12.23 Zinc finger, C2H2 type (3 domains) 84(a)
    (best of 2)
      X(14881084-14882208)   --
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes MIG36
    MIG26
    Probable transcriptional repressor involved in res...
    Protein containing zinc fingers, involved in repre...
    14(a)
    14(a)
    many ↔ many
    many ↔ many
    V(210692-211876) YER028C
    VII(95858-97006) YGL209W


    ENSEMBL Gene Tree for EGR1 (if available)
    TreeFam Gene Tree for EGR1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for EGR1 gene
    EGR32  EGR42  WT12  EGR22  
    2 SIMAP similar genes for EGR1 using alignment to 2 protein entries:     EGR1_HUMAN (see all proteins):
    EGR3    EGR2

    EGR1 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for EGR1 (see all 283)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 5 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1863329591,2
    --138075446(+) TGAGAC/GGCGCA 1 -- us2k10--------
    rs561099151,2
    C,F--138075477(+) AACTCG/CGTAGA 1 -- us2k17Minor allele frequency- C:0.31NA WA EA 366
    rs1501128681,2
    --138075538(+) CGAGAC/GGAGGG 1 -- us2k10--------
    rs1904389941,2
    --138075546(+) GGGAGA/TCCTGG 1 -- us2k10--------
    rs766069691,2
    C,F--138075635(+) CCCTCC/ACCCAC 1 -- us2k11Minor allele frequency- A:0.03WA 118
    rs2015388141,2
    C--138075673(-) CCCCAA/CCAGCC 1 -- us2k10--------
    rs775417891,2
    --138075913(+) GGAGAA/CCTGCG 1 -- us2k10--------
    rs38133211,2
    C,F,A,H--138076271(+) CCAGAC/TAGCCC 1 -- us2k120Minor allele frequency- T:0.28EA NS NA WA 3300
    rs1488193451,2
    --138076291(+) CCCCTA/CTTTCG 1 -- us2k10--------
    rs346200911,2
    C,F,H--138076363(+) CACCAC/TAAGGA 1 -- us2k110Minor allele frequency- T:0.02MN NS NA 1128

    HapMap Linkage Disequilibrium report for EGR1 (137801179 - 137805004 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 3 variations for EGR1:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv5024CNV Insertion18451855
    nsv528851CNV Loss19592680
    nsv5025CNV Loss18451855

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing EGR1
    DNA2.0 Custom Variant and Variant Library Synthesis for EGR1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 128990    OMIM disorders: --

    Selected diseases for EGR1 (see all 104):    About MalaCards
    normophosphatemic familial tumoral calcinosis    familial tumoral calcinosis    silicosis    prostate small cell carcinoma
    aortic valve disease    calcinosis    brain ischemia    fibrosarcoma
    small cell carcinoma    leiomyoma    nephroblastoma    hyperinsulinism
    duodenal ulcer    phaeochromocytoma    prion disease    teratocarcinoma
    wilms tumor    duodenitis    monocytic leukemia    ischemia

    2 diseases from the University of Copenhagen DISEASES database for EGR1:
    Cancer     Vascular disease

    EGR1 for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:
    The International Symposium on Pneumococci and Pneumococcal Diseases (ISPPD) 9 - 13 March 2014
    Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015

    Selected Novoseek inferred disease relationships for EGR1 gene (see all 77)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    wilms tumor 50.9 19 11106242 (5), 20123987 (2), 7823937 (1), 11734301 (1) (see all 12)
    tumors 47.6 195 9212230 (6), 15774784 (6), 19878561 (5), 16093249 (5) (see all 99)
    myeloid leukemia 37.1 5 1864967 (1), 8381016 (1), 7690249 (1), 7706752 (1) (see all 5)
    necrosis 36.8 32 11586099 (1), 14726502 (1), 18814180 (1), 1730654 (1) (see all 29)
    monocytic leukemia 33 3 11734301 (2), 2064996 (1)
    ocular dominance 31.2 3 8481787 (2), 11797318 (1)
    leukemia t-cell 31.1 1 1359492 (1)
    fibrosarcoma 30.9 15 8876223 (2), 9714058 (2), 11121417 (2), 7585551 (1) (see all 9)
    atherosclerosis 29.2 16 19036858 (2), 10712437 (2), 17967787 (2), 11676978 (1) (see all 10)
    carcinoma embryonal 29.2 6 1909429 (1), 8180132 (1), 8176254 (1), 9824160 (1) (see all 5)

    Genetic Association Database (GAD): EGR1
    Human Genome Epidemiology (HuGE) Navigator: EGR1 (7 documents)
    Tumor Gene Database (TGDB): EGR1

    Export disorders for EGR1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for EGR1 gene, integrated from 10 sources (see all 1027):
    (articles sorted by number of sources associating them with EGR1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Snail associates with EGR-1 and SP-1 to upregulate transcriptional activation of p15INK4b. (PubMed id 20121949)1, 2, 9 Hu C.T.... Wu W.S. (FEBS J. 2010)
    2. Association of early growth response-1 gene polymorphisms with total IgE and atopy in asthmatic children. (PubMed id 18507785)1, 4, 9 Chan I.H....Lam C.W. (Pediatr Allergy Immunol 2009)
    3. A gene coding for a zinc finger protein is induced during 12-O- tetradecanoylphorbol-13-acetate-stimulated HL-60 cell differentiation. (PubMed id 1569051)1, 2, 9 Shimizu N....Utiyama H. (J. Biochem. 1992)
    4. No association between EGR gene family polymorphisms and schizophrenia in the Chinese population. (PubMed id 20144677)1, 4 Liu B.C....He G. (amp 2010)
    5. High-level expression of early growth response-1 and association of polymorphism with total IgE and atopy in allergic rhinitis adults. (PubMed id 19833116)1, 4 Chan I.H....Lam C.W. ( international journal of clinical chemistry 2010)
    6. Evaluation of EGR1 as a candidate gene for high myopia. (PubMed id 18636116)1, 4 Li T....Zhang Q. (Mol. Vis. 2008)
    7. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    8. Expression of a zinc finger gene in HTLV-I- and HTLV-II-transformed cells. (PubMed id 2110381)1, 2 Wright J.J....Siebenlist U. (Science 1990)
    9. cDNA sequence of the human cellular early growth response gene Egr- 1. (PubMed id 2377485)1, 2 Suggs S.V.... Sukhatme V.P. (Nucleic Acids Res. 1990)
    10. A zinc finger-encoding gene coregulated with c-fos during growth and differentiation, and after cellular depolarization. (PubMed id 3127059)1, 3 Sukhatme V.P....Curran T. (Cell 1988)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 1958 HGNC: 3238 AceView: EGR1 Ensembl:ENSG00000120738 euGenes: HUgn1958
    ECgene: EGR1 Kegg: 1958 H-InvDB: EGR1

    (According to HUGE)
    About This Section

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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for EGR1 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for EGR1 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for EGR1 gene:
    Search GeneIP for patents involving EGR1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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