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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

EGR1 Gene

protein-coding   GIFtS: 69
GCID: GC05P137801

Early Growth Response 1

Microbiology & Infectious Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Early Growth Response 11 2     EGR-12 3
Nerve Growth Factor-Induced Protein A1 2 3     NGFI-A2 3
Transcription Factor ETR1031 2 3     ZNF2252 3
Zinc Finger Protein 2251 2 3     G0S302
Early Growth Response Protein 11 2     KROX-242
Transcription Factor Zif2682 3     TIS82
Zinc Finger Protein Krox-242 3     ZIF-2682
AT2252 3     KROX243

External Ids:    HGNC: 32381   Entrez Gene: 19582   Ensembl: ENSG000001207387   OMIM: 1289905   UniProtKB: P181463   

Export aliases for EGR1 gene to outside databases

Previous GC identifers: GC05P137675 GC05P138476 GC05P137832 GC05P137877 GC05P137829 GC05P132991


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for EGR1 Gene:
The protein encoded by this gene belongs to the EGR family of C2H2-type zinc-finger proteins. It is a nuclear
protein and functions as a transcriptional regulator. The products of target genes it activates are required for
differentitation and mitogenesis. Studies suggest this is a cancer suppresor gene. (provided by RefSeq, Jul 2008)

GeneCards Summary for EGR1 Gene: 
EGR1 (early growth response 1) is a protein-coding gene. Diseases associated with EGR1 include normophosphatemic familial tumoral calcinosis, and familial tumoral calcinosis, and among its related super-pathways are Development HGF signaling pathway and G-protein signaling Ras family GTPases in kinase cascades (scheme). GO annotations related to this gene include transcription factor binding and sequence-specific DNA binding transcription factor activity. An important paralog of this gene is EGR3.

UniProtKB/Swiss-Prot: EGR1_HUMAN, P18146
Function: Transcriptional regulator. Recognizes and binds to the DNA sequence 5'-CGCCCCCGC-3'(EGR-site). Activates
the transcription of target genes whose products are required for mitogenesis and differentiation

Gene Wiki entry for EGR1 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000005.9  NC_018916.2  NT_034772.6  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the EGR1 gene promoter:
         GR   CREB   GR-beta   deltaCREB   GR-alpha   c-Ets-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): EGR1 promoter sequence
   Search SABiosciences Chromatin IP Primers for EGR1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat EGR1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 5q31.1   Ensembl cytogenetic band:  5q31.2   HGNC cytogenetic band: 5q23-q31

EGR1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
EGR1 gene location

GeneLoc information about chromosome 5         GeneLoc Exon Structure

GeneLoc location for GC05P137801:  view genomic region     (about GC identifiers)

Start:
137,801,179 bp from pter      End:
137,805,004 bp from pter
Size:
3,826 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: EGR1_HUMAN, P18146 (See protein sequence)
Recommended Name: Early growth response protein 1  
Size: 543 amino acids; 57507 Da
Subunit: Interacts with SNAI1 and SP1 upon 12-O-tetradecanoylphorbol-13-acetate (TPA) induction
Subcellular location: Nucleus

Explore the universe of human proteins at neXtProt for EGR1: NX_P18146

Explore proteomics data for EGR1 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_P18146

  • EGR1 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    EGR1 Protein Expression
    REFSEQ proteins: NP_001955.1  
    ENSEMBL proteins: 
     ENSP00000239938  
    Reactome Protein details: P18146
    Human Recombinant Protein Products for EGR1: 
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    Novus Biologicals EGR1 Protein
    Novus Biologicals EGR1 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for EGR1 

    Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus ISS--
    GO:0005654nucleoplasm TAS--
    GO:0005737cytoplasm ISS--

    EGR1 for ontologies           About GeneDecksing



    EGR1 Antibody Products: 
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    Assay Products for EGR1: 
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    Cloud-Clone Corp. ELISAs for EGR1 
    Cloud-Clone Corp. CLIAs for EGR1


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    ZNF: Zinc fingers, C2H2-type

    5 InterPro protein domains:
     IPR015880 Znf_C2H2-like
     IPR021839 DUF3432
     IPR013087 Znf_C2H2/integrase_DNA-bd
     IPR007087 Znf_C2H2
     IPR021849 DUF3446

    Graphical View of Domain Structure for InterPro Entry P18146

    ProtoNet protein and cluster: P18146

    1 Blocks protein domain: IPB007086 C2H2-type zinc finger signature

    UniProtKB/Swiss-Prot: EGR1_HUMAN, P18146
    Similarity: Belongs to the EGR C2H2-type zinc-finger protein family
    Similarity: Contains 3 C2H2-type zinc fingers


    EGR1 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: EGR1_HUMAN, P18146
    Function: Transcriptional regulator. Recognizes and binds to the DNA sequence 5'-CGCCCCCGC-3'(EGR-site). Activates
    the transcription of target genes whose products are required for mitogenesis and differentiation
    Induction: By growth factors

         Genatlas biochemistry entry for EGR1:
    immediate early growth response,gene 1 (pAT225),nerve growth factor induced clone A,specifically expressed in
    Schwann cells,induced by a wide variety of extracellular stimuli,involved in cell proliferation,macrophage
    differentiation,synaptic activation and long term potentiation,coactivated by CREBBP

         Gene Ontology (GO): 5/15 molecular function terms (GO ID links to tree view) (see all 15):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000976transcription regulatory region sequence-specific DNA binding IDA18718911
    GO:0000977RNA polymerase II regulatory region sequence-specific DNA binding ----
    GO:0000979RNA polymerase II core promoter sequence-specific DNA binding IEA--
    GO:0000982RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity ----
    GO:0001077RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription IEA--
         
    EGR1 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for EGR1:
     Synthetic lethal with c-Myc af 

         15/17 MGI mutant phenotypes (inferred from 4 alleles(MGI details for Egr1) (see all 17):
     behavior/neurological  cardiovascular system  cellular  endocrine/exocrine gland  growth/size 
     hematopoietic system  homeostasis/metabolism  immune system  integument  liver/biliary system 
     mortality/aging  nervous system  reproductive system  respiratory system  skeleton 

    EGR1 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-outs for EGR1: Egr1tm1Jmi Egr1tm1The

       inGenious Targeting Laboratory - Custom generated mouse model solutions for EGR1 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for EGR1

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for EGR1 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for EGR1 

    miRNA
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    miRTarBase miRNAs that target EGR1:
    hsa-mir-192 (MIRT004130)

    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat EGR1
    8/46 QIAGEN miScript miRNA Assays for microRNAs that regulate EGR1 (see all 46):
    hsa-miR-548j hsa-miR-24-1* hsa-miR-199a-3p hsa-miR-124 hsa-miR-548d-5p hsa-miR-548a-5p hsa-miR-506 hsa-miR-510
    SwitchGear 3'UTR luciferase reporter plasmidEGR1 3' UTR sequence
    Inhib. RNA
    Products:
        
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    Clone
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                         Customized lentivirus expression plasmids for stable overexpression of EGR1 

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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for EGR1


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for EGR1 About   (see all 31)                                                                                              See pathways by source

    SuperPathContained pathways About
    1Development HGF signaling pathway
    Development HGF signaling pathway0.78
    Signaling events mediated by Hepatocyte Growth Factor Receptor (c-Met)0.31
    Apoptosis and survival Role of CDK5 in neuronal death and survival0.37
    2G-protein signaling Ras family GTPases in kinase cascades (scheme)
    Immune response Oncostatin M signaling via MAPK in human cells0.39
    Oncostatin M Signaling Pathway0.37
    3Interferon Signaling
    Interferon Signaling0.61
    Cytokine Signaling in Immune system0.61
    4Immune response IL-2 activation and signaling pathway
    Immune response IL-3 activation and signaling pathway0.41
    Immune response IL-2 activation and signaling pathway0.41
    5Development Hedgehog and PTH signaling pathways in bone and cartilage development
    Development Hedgehog and PTH signaling pathways in bone and cartilage development0.97

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    5/10 EMD Millipore Pathways for EGR1 (see all 10)
        Development Hedgehog and PTH signaling pathways in bone and cartilage development
    Development Growth hormone signaling via PI3K/AKT and MAPK cascades
    Immune response BCR pathway
    Apoptosis and survival Role of CDK5 in neuronal death and survival
    Transcription factors in neurogenesis

    1 Downloadable PowerPoint Slide of QIAGEN Pathway Central Maps for EGR1
        CDK5 Pathway

    1 Cell Signaling Technology (CST) Pathway for EGR1
        Neuroscience

    5/10 GeneGo (Thomson Reuters) Pathways for EGR1 (see all 10)
        Development Hedgehog and PTH signaling pathways in bone and cartilage development
    Development Leptin signaling via JAK/STAT and MAPK cascades
    Immune response BCR pathway
    Development ACM2 and ACM4 activation of ERK
    Immune response IL-2 activation and signaling pathway

    5/17 BioSystems Pathways for EGR1 (see all 17)
        Insulin Signaling
    Serotonin Receptor 4/6/7 and NR3C Signaling
    SIDS Susceptibility Pathways
    Spinal Cord Injury
    Oncostatin M Signaling Pathway

    4        Reactome Pathways for EGR1
        Interferon alpha/beta signaling
    Cytokine Signaling in Immune system
    Interferon Signaling
    Immune System


    2         Kegg Pathways  (Kegg details for EGR1):
        Prion diseases
    HTLV-I infection


    EGR1 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for EGR1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/82 Interacting proteins for EGR1 (P181461, 2, 3 ENSP000002399384) via UniProtKB, MINT, STRING, and/or I2D (see all 82)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CDKN2AQ8N7262, 3, ENSP000003551534MINT-7011792 MINT-7011820 MINT-7011781 MINT-7011806 I2D: score=1 STRING: ENSP00000355153
    TP53P046372, 3, ENSP000002693054MINT-4793180 I2D: score=5 STRING: ENSP00000269305
    EP300Q094722, 3, ENSP000002632534MINT-7306489 MINT-7306512 MINT-7306501 I2D: score=4 STRING: ENSP00000263253
    VDRP114732, ENSP000002290224MINT-7306489 MINT-7306512 MINT-7306501 STRING: ENSP00000229022
    SUMO1P631652, 3, ENSP000003760764MINT-7011835 I2D: score=1 STRING: ENSP00000376076
    About this table

    Gene Ontology (GO): 5/52 biological process terms (GO ID links to tree view) (see all 52):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000122negative regulation of transcription from RNA polymerase II promoter IEA--
    GO:0001975response to amphetamine IEA--
    GO:0006355regulation of transcription, DNA-dependent ----
    GO:0006366transcription from RNA polymerase II promoter IDA19057511
    GO:0007611learning or memory IEA--

    EGR1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    EGR1 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for EGR1

    10/122 Novoseek inferred chemical compound relationships for EGR1 gene (see all 122)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    zinc 66.8 120 8132543 (4), 9485332 (3), 8336701 (2), 10671503 (2) (see all 72)
    pd 98,059 65.8 24 17230532 (2), 11121417 (2), 12483323 (1), 12457461 (1) (see all 22)
    ptx1 55.9 4 10859489 (2), 10082522 (1), 15469090 (1)
    12-o-tetradecanoylphorbol 13-acetate 54.6 37 15910736 (4), 8018558 (2), 1417981 (2), 11751871 (1) (see all 16)
    nogalamycin 52.7 2 8798634 (1), 11222751 (1)
    phorbol-12-myristate 48 4 7519845 (1), 11007455 (1), 15231681 (1), 10674404 (1)
    sulindac sulfide 42.4 9 17599376 (4), 16079301 (2), 15509713 (1)
    phosphatidylinositol 41.3 28 10050043 (4), 8302296 (2), 16424010 (2), 11403719 (2) (see all 18)
    vegf 41.3 48 19526316 (7), 11149911 (5), 10339488 (4), 16103054 (4) (see all 21)
    ly294002 40.4 14 16489044 (3), 18831964 (2), 15449318 (1), 17715378 (1) (see all 7)

    Search CenterWatch for drugs/clinical trials and news about EGR1

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
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    About This Section

    REFSEQ mRNAs for EGR1 gene: 
    NM_001964.2  

    Unigene Clusters for EGR1:

    Early growth response 1
    Hs.326035  [show with all ESTs], Hs.708393  [show with all ESTs]
    Unigene Representative Sequences: NM_001964, CD522629
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000239938(uc003ldb.1)
    Congresses - knowledge worth sharing:  
    European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

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    8/46 QIAGEN miScript miRNA Assays for microRNAs that regulate EGR1 (see all 46):
    hsa-miR-548j hsa-miR-24-1* hsa-miR-199a-3p hsa-miR-124 hsa-miR-548d-5p hsa-miR-548a-5p hsa-miR-506 hsa-miR-510
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    DNA2.0 Custom Codon Optimized Gene Synthesis Service for EGR1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat EGR1
    Sirion Biotech Customized lentivirus for stable overexpression of EGR1 
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    Primer
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    OriGene qPCR primer pairs and template standards for EGR1
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat EGR1
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat EGR1

    Additional mRNA sequence: M24019.1 

    16 DOTS entries:

    DT.451515  DT.92410441  DT.100815176  DT.92444091  DT.92444078  DT.100815174  DT.100652567  DT.100815170 
    DT.100838251  DT.120828084  DT.75188226  DT.92444088  DT.95168866  DT.95288077  DT.91927235  DT.95243780 

    24/292 AceView cDNA sequences (see all 292):

    AI625815 AL602754 AI978658 BU198010 AA300267 BF438983 AA300268 CA435715 
    AI701078 R83762 M62829 BQ447364 BQ896662 AI083849 BM854744 AA679209 
    BQ181084 AA327475 AI937024 BM310258 AA635527 BX425480 CD238597 AA366121 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    EGR1 expression in normal human tissues (normalized intensities)      EGR1 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GGATATGTGG
    EGR1 Expression
    About this image


    EGR1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/15 selected tissues (see all 15) fully expand
     
     Brain (Nervous System)    fully expand to see all 18 entries
             Adult Dopaminergic Neurons Ventral Tegmental Area
             Thalamus
             Trigeminal Ganglion   
     
     Kidney (Urinary System)    fully expand to see all 16 entries
             Ureteric Bud Tip Cells Ureteric Bud
             S-shaped Body
             visceral organ/mesonephros of male/paramesonephric duct of male, mesonephric portion   
     
     Lower Urinary Tract (Urinary System)    fully expand to see all 3 entries
             visceral organ   
     
     Tendon & Ligament (Muscoskeletal System)    fully expand to see all 3 entries
             Early Tenocyte Cells Limb Tendon Primordia
     
     Mesoderm (Gastrulation Derivatives)    fully expand to see all 2 entries
             Limb Bud Mesenchyme Cells Limb Bud
             mesenchyme   

    See EGR1 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for EGR1

    SOURCE GeneReport for Unigene clusters: Hs.326035 Hs.708393
        SABiosciences Expression via Pathway-Focused PCR Arrays including EGR1 (see all 19): 
              Multiple Sclerosis in human mouse rat
              Nitric Oxide Signaling Pathway in human mouse rat
              Hypoxia Signaling Pathway in human mouse rat
              T-cell & B-cell Activation in human mouse rat
              cAMP / Ca2+ Signaling PathwayFinder in human mouse rat

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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for EGR1 gene from 6/13 species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Egr11 , 5 early growth response 11, 5 87.59(n)1
    93.42(a)1
      18 (18.76 cM)5
    136531  NM_007913.51  NP_031939.11 
     348598235 
    chicken
    (Gallus gallus)
    Aves EGR11 early growth response 1 73.2(n)
    76.04(a)
      373931  NM_204136.2  NP_989467.2 
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.6372 Xenopus laevis early growth response protein mRNA, more 77.47(n)    AF250345.1 
    zebrafish
    (Danio rerio)
    Actinopterygii egr12 early growth response 1 76.22(n)   30498  NM_131248.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta sr3 tracheal cell migration (sensu Insecta)
    RNA polymerase more
    76(a)     --
    worm
    (Caenorhabditis elegans)
    Secernentea C27C12.23 Zinc finger, C2H2 type (3 domains) 84(a)
    (best of 2)
      X(14881084-14882208)   --


    ENSEMBL Gene Tree for EGR1 (if available)
    TreeFam Gene Tree for EGR1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for EGR1 gene
    EGR32  EGR42  WT12  EGR22  
    2 SIMAP similar genes for EGR1 using alignment to 2 protein entries:     EGR1_HUMAN (see all proteins):
    EGR3    EGR2

    EGR1 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/283 SNPs in EGR1 are shown (see all 283)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 5 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1863329591,2
    --138075446(+) TGAGAC/GGCGCA 1 -- us2k10--------
    rs561099151,2
    C,F--138075477(+) AACTCG/CGTAGA 1 -- us2k17Minor allele frequency- C:0.31NA WA EA 366
    rs1501128681,2
    --138075538(+) CGAGAC/GGAGGG 1 -- us2k10--------
    rs1904389941,2
    --138075546(+) GGGAGA/TCCTGG 1 -- us2k10--------
    rs766069691,2
    C,F--138075635(+) CCCTCC/ACCCAC 1 -- us2k11Minor allele frequency- A:0.03WA 118
    rs2015388141,2
    C--138075673(-) CCCCAA/CCAGCC 1 -- us2k10--------
    rs775417891,2
    --138075913(+) GGAGAA/CCTGCG 1 -- us2k10--------
    rs38133211,2
    C,F,A,H--138076271(+) CCAGAC/TAGCCC 1 -- us2k120Minor allele frequency- T:0.28EA NS NA WA 3300
    rs1488193451,2
    --138076291(+) CCCCTA/CTTTCG 1 -- us2k10--------
    rs346200911,2
    C,F,H--138076363(+) CACCAC/TAAGGA 1 -- us2k110Minor allele frequency- T:0.02MN NS NA 1128

    HapMap Linkage Disequilibrium report for EGR1 (137801179 - 137805004 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 3 variations for EGR1:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv5024CNV Insertion18451855
    nsv528851CNV Loss19592680
    nsv5025CNV Loss18451855

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 128990    OMIM disorders: --

    20/101 diseases for EGR1 (see all 101):    About MalaCards
    normophosphatemic familial tumoral calcinosis    familial tumoral calcinosis    silicosis    prostate small cell carcinoma
    calcinosis    brain ischemia    small cell carcinoma    fibrosarcoma
    leiomyoma    duodenal ulcer    prion disease    nephroblastoma
    hyperinsulinism    wilms tumor    phaeochromocytoma    teratocarcinoma
    duodenitis    monocytic leukemia    esophagitis    ischemia

    2 diseases from the University of Copenhagen DISEASES database for EGR1:
    Cancer     Vascular disease

    EGR1 for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:  
    Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015

    10/77 Novoseek inferred disease relationships for EGR1 gene (see all 77)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    wilms tumor 50.9 19 11106242 (5), 20123987 (2), 7823937 (1), 11734301 (1) (see all 12)
    tumors 47.6 195 9212230 (6), 15774784 (6), 19878561 (5), 16093249 (5) (see all 99)
    myeloid leukemia 37.1 5 1864967 (1), 8381016 (1), 7690249 (1), 7706752 (1) (see all 5)
    necrosis 36.8 32 11586099 (1), 14726502 (1), 18814180 (1), 1730654 (1) (see all 29)
    monocytic leukemia 33 3 11734301 (2), 2064996 (1)
    ocular dominance 31.2 3 8481787 (2), 11797318 (1)
    leukemia t-cell 31.1 1 1359492 (1)
    fibrosarcoma 30.9 15 8876223 (2), 9714058 (2), 11121417 (2), 7585551 (1) (see all 9)
    atherosclerosis 29.2 16 19036858 (2), 10712437 (2), 17967787 (2), 11676978 (1) (see all 10)
    carcinoma embryonal 29.2 6 1909429 (1), 8180132 (1), 8176254 (1), 9824160 (1) (see all 5)

    Genetic Association Database (GAD): EGR1
    Human Genome Epidemiology (HuGE) Navigator: EGR1 (7 documents)
    Tumor Gene Database (TGDB): EGR1

    Export disorders for EGR1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for EGR1 gene, integrated from 9 sources (see all 1012):
    (articles sorted by number of sources associating them with EGR1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Snail associates with EGR-1 and SP-1 to upregulate tr anscriptional activation of p15INK4b. (PubMed id 20121949)1, 2, 9 Hu C.T....Wu W.S. (2010)
    2. Association of early growth response-1 gene polymorphisms with total IgE and atopy in asthmatic children. (PubMed id 18507785)1, 4, 9 Chan I.H....Lam C.W. (2008)
    3. A gene coding for a zinc finger protein is induced during 12-O- tetradecanoylphorbol-13-acetate-stimulated HL-60 cell differentiation. (PubMed id 1569051)1, 2, 9 Shimizu N....Utiyama H. (1992)
    4. No association between EGR gene family polymorphisms and schizophrenia in the Chinese population. (PubMed id 20144677)1, 4 Liu B.C....He G. (2010)
    5. High-level expression of early growth response-1 and association of polymorphism with total IgE and atopy in allergic rhinitis adult s. (PubMed id 19833116)1, 4 Chan I.H....Lam C.W. (2010)
    6. Evaluation of EGR1 as a candidate gene for high myopia. (PubMed id 18636116)1, 4 Li T....Zhang Q. (2008)
    7. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    8. Expression of a zinc finger gene in HTLV-I- and HTLV-II-transformed cells. (PubMed id 2110381)1, 2 Wright J.J....Siebenlist U. (1990)
    9. cDNA sequence of the human cellular early growth response gene Egr- 1. (PubMed id 2377485)1, 2 Suggs S.V.... Sukhatme V.P. (1990)
    10. A zinc finger-encoding gene coregulated with c-fos during growth and differentiation, and after cellular depolarization. (PubMed id 3127059)1, 3 Sukhatme V.P....Curran T. (1988)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 1958 HGNC: 3238 AceView: EGR1 Ensembl:ENSG00000120738 euGenes: HUgn1958
    ECgene: EGR1 Kegg: 1958 H-InvDB: EGR1

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for EGR1 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for EGR1 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for EGR1 gene:
    Search GeneIP for patents involving EGR1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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