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Aliases for EGLN3 Gene

Aliases for EGLN3 Gene

  • Egl-9 Family Hypoxia Inducible Factor 3 2 3 5
  • Prolyl Hydroxylase Domain-Containing Protein 3 3 4
  • Hypoxia-Inducible Factor Prolyl Hydroxylase 3 3 4
  • HIF-Prolyl Hydroxylase 3 3 4
  • HIF-PH3 3 4
  • HPH-1 3 4
  • HPH-3 3 4
  • PHD3 3 4
  • Egl Nine Homolog 3 (C. Elegans) 2
  • Egl Nine-Like Protein 3 Isoform 3
  • HIF Prolyl Hydroxylase 3 2
  • Egl Nine Homolog 3 3
  • EC 1.14.11.29 4
  • EC 1.14.11 61
  • HIFP4H3 3
  • HIFPH3 3

External Ids for EGLN3 Gene

Previous GeneCards Identifiers for EGLN3 Gene

  • GC14M031770
  • GC14M028180
  • GC14M032383
  • GC14M033463
  • GC14M034393
  • GC14M014510

Summaries for EGLN3 Gene

GeneCards Summary for EGLN3 Gene

EGLN3 (Egl-9 Family Hypoxia Inducible Factor 3) is a Protein Coding gene. Diseases associated with EGLN3 include Hypoxia and Chronic Mountain Sickness. Among its related pathways are CDK-mediated phosphorylation and removal of Cdc6 and Development HGF signaling pathway. GO annotations related to this gene include oxidoreductase activity and oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen. An important paralog of this gene is EGLN2.

UniProtKB/Swiss-Prot for EGLN3 Gene

  • Cellular oxygen sensor that catalyzes, under normoxic conditions, the post-translational formation of 4-hydroxyproline in hypoxia-inducible factor (HIF) alpha proteins. Hydroxylates a specific proline found in each of the oxygen-dependent degradation (ODD) domains (N-terminal, NODD, and C-terminal, CODD) of HIF1A. Also hydroxylates HIF2A. Has a preference for the CODD site for both HIF1A and HIF2A. Hydroxylation on the NODD site by EGLN3 appears to require prior hydroxylation on the CODD site. Hydroxylated HIFs are then targeted for proteasomal degradation via the von Hippel-Lindau ubiquitination complex. Under hypoxic conditions, the hydroxylation reaction is attenuated allowing HIFs to escape degradation resulting in their translocation to the nucleus, heterodimerization with HIF1B, and increased expression of hypoxy-inducible genes. EGLN3 is the most important isozyme in limiting physiological activation of HIFs (particularly HIF2A) in hypoxia. Also hydroxylates PKM in hypoxia, limiting glycolysis. Under normoxia, hydroxylates and regulates the stability of ADRB2. Regulator of cardiomyocyte and neuronal apoptosis. In cardiomyocytes, inhibits the anti-apoptotic effect of BCL2 by disrupting the BAX-BCL2 complex. In neurons, has a NGF-induced proapoptotic effect, probably through regulating CASP3 activity. Also essential for hypoxic regulation of neutrophilic inflammation. Plays a crucial role in DNA damage response (DDR) by hydroxylating TELO2, promoting its interaction with ATR which is required for activation of the ATR/CHK1/p53 pathway. Target proteins are preferentially recognized via a LXXLAP motif.

Gene Wiki entry for EGLN3 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for EGLN3 Gene

Genomics for EGLN3 Gene

Regulatory Elements for EGLN3 Gene

Enhancers for EGLN3 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH14G034059 1.9 FANTOM5 Ensembl ENCODE dbSUPER 3.5 +402.5 402477 2.5 HDGF PKNOX1 CREB3L1 ARID4B SIN3A DMAP1 SLC30A9 FOS SP3 MXD4 EGLN3 GC14M034058 LOC105370444
GH14G034037 1.4 FANTOM5 ENCODE dbSUPER 4.4 +423.8 423820 2.1 TBP ELF3 FOXA2 MLX ARID4B ZSCAN9 RARA SLC30A9 FOS MIXL1 EGLN3 EGLN3-AS1 LOC105370446
GH14G034203 0.8 ENCODE 6.4 +259.2 259235 0.4 ELF3 CTCF SAP130 ZNF792 RAD21 CTBP1 GATA3 SMC3 FOSL2 FOS EGLN3 LOC102724945 LOC105370444
GH14G034063 1.7 FANTOM5 Ensembl ENCODE dbSUPER 1.8 +399.1 399052 1.2 ELF3 FOXA2 ATF1 MLX ARID4B RAD21 ZNF48 RARA SLC30A9 GATA4 EGLN3 GC14M034058 LOC105370444
GH14G034464 1.2 Ensembl ENCODE 0.7 -2.6 -2574 1.3 HDGF ATF1 FOXA2 ARNT TCF12 ZNF766 CBX5 FOS ZNF518A ZNF592 EGLN3 RPL23AP71
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around EGLN3 on UCSC Golden Path with GeneCards custom track

Promoters for EGLN3 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000067557 874 2201 HDGF PKNOX1 FOXA2 MLX ZFP64 ARID4B SIN3A YBX1 FEZF1 DMAP1

Genomic Location for EGLN3 Gene

Chromosome:
14
Start:
33,924,215 bp from pter
End:
34,462,774 bp from pter
Size:
538,560 bases
Orientation:
Minus strand

Genomic View for EGLN3 Gene

Genes around EGLN3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
EGLN3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for EGLN3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for EGLN3 Gene

Proteins for EGLN3 Gene

  • Protein details for EGLN3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9H6Z9-EGLN3_HUMAN
    Recommended name:
    Egl nine homolog 3
    Protein Accession:
    Q9H6Z9
    Secondary Accessions:
    • Q2TA79
    • Q3B8N4
    • Q6P1R2

    Protein attributes for EGLN3 Gene

    Size:
    239 amino acids
    Molecular mass:
    27261 Da
    Cofactor:
    Name=Fe(2+); Xref=ChEBI:CHEBI:29033;
    Cofactor:
    Name=L-ascorbate; Xref=ChEBI:CHEBI:38290;
    Quaternary structure:
    • Interacts with WDR83; the interaction leads to almost complete elimination of HIF-mediated reporter activity (By similarity). Interacts with BCL2 (via its BH4 domain); the interaction disrupts the BAX-BCL4 complex inhibiting the anti-apoptotic activity of BCL2. Interacts with ADRB2; the interaction hydroxylates ADRB2 facilitating its ubiquitination by the VHL-E3 ligase complex. Interacts with PAX2; the interaction targets PAX2 for destruction. Interacts with PKM; the interaction hydroxylates PKM in hypoxia.

neXtProt entry for EGLN3 Gene

Selected DME Specific Peptides for EGLN3 Gene

Q9H6Z9:
  • ALEYIVPC
  • RGDQITWI
  • GYVRHVDNP
  • TVWYFDA
  • FDRLLFFWSDRRNPHEVQP
  • GDGRCITCIYYLN

Post-translational modifications for EGLN3 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for EGLN3 Gene

Domains & Families for EGLN3 Gene

Protein Domains for EGLN3 Gene

Suggested Antigen Peptide Sequences for EGLN3 Gene

Graphical View of Domain Structure for InterPro Entry

Q9H6Z9

UniProtKB/Swiss-Prot:

EGLN3_HUMAN :
  • The Beta(2)beta(3) finger-like loop domain is important for substrate (HIFs CODD/NODD) selectivity.
Domain:
  • The Beta(2)beta(3) finger-like loop domain is important for substrate (HIFs CODD/NODD) selectivity.
genes like me logo Genes that share domains with EGLN3: view

No data available for Gene Families for EGLN3 Gene

Function for EGLN3 Gene

Molecular function for EGLN3 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
Hypoxia-inducible factor-L-proline + 2-oxoglutarate + O(2) = hypoxia-inducible factor-trans-4-hydroxy-L-proline + succinate + CO(2).
UniProtKB/Swiss-Prot EnzymeRegulation:
Activated in cardiovascular cells and Hela cells following exposure to hypoxia. Inhibited by polynitrogen compounds probably by chelation to Fe(2+) ions.
UniProtKB/Swiss-Prot Function:
Cellular oxygen sensor that catalyzes, under normoxic conditions, the post-translational formation of 4-hydroxyproline in hypoxia-inducible factor (HIF) alpha proteins. Hydroxylates a specific proline found in each of the oxygen-dependent degradation (ODD) domains (N-terminal, NODD, and C-terminal, CODD) of HIF1A. Also hydroxylates HIF2A. Has a preference for the CODD site for both HIF1A and HIF2A. Hydroxylation on the NODD site by EGLN3 appears to require prior hydroxylation on the CODD site. Hydroxylated HIFs are then targeted for proteasomal degradation via the von Hippel-Lindau ubiquitination complex. Under hypoxic conditions, the hydroxylation reaction is attenuated allowing HIFs to escape degradation resulting in their translocation to the nucleus, heterodimerization with HIF1B, and increased expression of hypoxy-inducible genes. EGLN3 is the most important isozyme in limiting physiological activation of HIFs (particularly HIF2A) in hypoxia. Also hydroxylates PKM in hypoxia, limiting glycolysis. Under normoxia, hydroxylates and regulates the stability of ADRB2. Regulator of cardiomyocyte and neuronal apoptosis. In cardiomyocytes, inhibits the anti-apoptotic effect of BCL2 by disrupting the BAX-BCL2 complex. In neurons, has a NGF-induced proapoptotic effect, probably through regulating CASP3 activity. Also essential for hypoxic regulation of neutrophilic inflammation. Plays a crucial role in DNA damage response (DDR) by hydroxylating TELO2, promoting its interaction with ATR which is required for activation of the ATR/CHK1/p53 pathway. Target proteins are preferentially recognized via a LXXLAP motif.
UniProtKB/Swiss-Prot Induction:
Induced by hypoxia in a number of cells including neutrophils and certain cancer cell lines. Up-regulated 10-fold in pancreatic cancers.

Enzyme Numbers (IUBMB) for EGLN3 Gene

Gene Ontology (GO) - Molecular Function for EGLN3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005506 iron ion binding IEA --
GO:0005515 protein binding IPI 15721254
GO:0016491 oxidoreductase activity IEA --
GO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen IEA --
GO:0016706 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors IDA 22955912
genes like me logo Genes that share ontologies with EGLN3: view
genes like me logo Genes that share phenotypes with EGLN3: view

Animal Models for EGLN3 Gene

MGI Knock Outs for EGLN3:

Animal Model Products

  • Taconic Biosciences Mouse Models for EGLN3

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for EGLN3

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for EGLN3 Gene

Localization for EGLN3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for EGLN3 Gene

Nucleus. Cytoplasm. Note=Colocalizes with WDR83 in the cytoplasm. {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for EGLN3 gene
Compartment Confidence
nucleus 5
cytosol 5
extracellular 1
mitochondrion 1
endoplasmic reticulum 1

Gene Ontology (GO) - Cellular Components for EGLN3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA,IEA 12615973
GO:0005654 nucleoplasm TAS --
GO:0005737 cytoplasm IEA,IDA 12615973
GO:0005829 cytosol TAS,IDA --
genes like me logo Genes that share ontologies with EGLN3: view

Pathways & Interactions for EGLN3 Gene

genes like me logo Genes that share pathways with EGLN3: view

Gene Ontology (GO) - Biological Process for EGLN3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001666 response to hypoxia IEP 20978507
GO:0006915 apoptotic process IEP 20978507
GO:0006919 activation of cysteine-type endopeptidase activity involved in apoptotic process IEP 20978507
GO:0006974 cellular response to DNA damage stimulus IEA --
GO:0018126 protein hydroxylation IDA 19584355
genes like me logo Genes that share ontologies with EGLN3: view

No data available for SIGNOR curated interactions for EGLN3 Gene

Drugs & Compounds for EGLN3 Gene

(9) Drugs for EGLN3 Gene - From: DrugBank, ApexBio, DGIdb, HMDB, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Vitamin C Approved Nutra Target 531,531
Oxygen Approved, Vet_approved Pharma 0
hydroxyproline Approved, Experimental Pharma 0
L-Proline Approved Nutra 0
Succinic acid Approved Nutra Full agonist, Agonist 0

(3) Additional Compounds for EGLN3 Gene - From: HMDB and Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Oxoglutaric acid
  • 2-Ketoglutarate
  • 2-Ketoglutaric acid
  • 2-Oxo-1,5-pentanedioate
  • 2-Oxo-1,5-pentanedioic acid
  • 2-Oxoglutarate
328-50-7

(1) ApexBio Compounds for EGLN3 Gene

Compound Action Cas Number
FG2216 HIF-prolyl hydroxylase inhibitor 223387-75-5
genes like me logo Genes that share compounds with EGLN3: view

Drug Products

Transcripts for EGLN3 Gene

Unigene Clusters for EGLN3 Gene

Egl nine homolog 3 (C. elegans):
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for EGLN3

Alternative Splicing Database (ASD) splice patterns (SP) for EGLN3 Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3 ^ 4 ^ 5a · 5b · 5c
SP1: -
SP2: - -
SP3:

Relevant External Links for EGLN3 Gene

GeneLoc Exon Structure for
EGLN3
ECgene alternative splicing isoforms for
EGLN3

Expression for EGLN3 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for EGLN3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for EGLN3 Gene

This gene is overexpressed in Heart - Left Ventricle (x6.6), Skin - Not Sun Exposed (Suprapubic) (x5.3), Skin - Sun Exposed (Lower leg) (x4.8), and Heart - Atrial Appendage (x4.4).

Protein differential expression in normal tissues from HIPED for EGLN3 Gene

This gene is overexpressed in Urinary Bladder (22.5), Heart (13.6), Gallbladder (10.9), Ovary (9.0), and Peripheral blood mononuclear cells (6.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for EGLN3 Gene



Protein tissue co-expression partners for EGLN3 Gene

NURSA nuclear receptor signaling pathways regulating expression of EGLN3 Gene:

EGLN3

SOURCE GeneReport for Unigene cluster for EGLN3 Gene:

Hs.135507

mRNA Expression by UniProt/SwissProt for EGLN3 Gene:

Q9H6Z9-EGLN3_HUMAN
Tissue specificity: Widely expressed at low levels. Expressed at higher levels in adult heart (cardiac myocytes, aortic endothelial cells and coronary artery smooth muscle), lung and placenta, and in fetal spleen, heart and skeletal muscle. Also expressed in pancreas. Localized to pancreatic acini and islet cells.

Evidence on tissue expression from TISSUES for EGLN3 Gene

  • Intestine(4.3)
  • Lung(4.2)
  • Skin(2.9)
  • Heart(2.8)
  • Muscle(2.6)
  • Nervous system(2.6)
  • Kidney(2)
genes like me logo Genes that share expression patterns with EGLN3: view

Primer Products

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for EGLN3 Gene

Orthologs for EGLN3 Gene

This gene was present in the common ancestor of animals.

Orthologs for EGLN3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia EGLN3 34 35
  • 99.86 (n)
dog
(Canis familiaris)
Mammalia EGLN3 34 35
  • 94.14 (n)
oppossum
(Monodelphis domestica)
Mammalia EGLN3 35
  • 93 (a)
OneToOne
cow
(Bos Taurus)
Mammalia EGLN3 34 35
  • 92.61 (n)
mouse
(Mus musculus)
Mammalia Egln3 16 35 34
  • 91.91 (n)
rat
(Rattus norvegicus)
Mammalia Egln3 34
  • 91.49 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia EGLN3 35
  • 90 (a)
OneToOne
chicken
(Gallus gallus)
Aves EGLN3 34 35
  • 82.71 (n)
lizard
(Anolis carolinensis)
Reptilia EGLN3 35
  • 85 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia egln3 34
  • 69.32 (n)
African clawed frog
(Xenopus laevis)
Amphibia Xl.16140 34
zebrafish
(Danio rerio)
Actinopterygii egln3 34 35
  • 66.22 (n)
wufj78a08 34
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.8898 34
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP003523 34
  • 59.97 (n)
fruit fly
(Drosophila melanogaster)
Insecta Hph 35
  • 22 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea egl-9 35
  • 13 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 30 (a)
OneToMany
Species where no ortholog for EGLN3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for EGLN3 Gene

ENSEMBL:
Gene Tree for EGLN3 (if available)
TreeFam:
Gene Tree for EGLN3 (if available)

Paralogs for EGLN3 Gene

Paralogs for EGLN3 Gene

(2) SIMAP similar genes for EGLN3 Gene using alignment to 6 proteins:

Pseudogenes.org Pseudogenes for EGLN3 Gene

genes like me logo Genes that share paralogs with EGLN3: view

Variants for EGLN3 Gene

Sequence variations from dbSNP and Humsavar for EGLN3 Gene

SNP ID Clin Chr 14 pos Sequence Context AA Info Type
rs1000058478 -- 33,940,628(+) TTCCA(C/G)ATAAT intron-variant
rs1000182950 -- 33,936,513(+) TGACT(A/G)TGGCC intron-variant
rs1000232779 -- 33,931,807(+) ACAAC(A/T)CAGGG intron-variant
rs1000405346 -- 33,949,277(+) TCAGC(A/G)TATTA intron-variant
rs1000603036 -- 33,941,936(+) GAAAG(A/C/G)AAGGC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for EGLN3 Gene

Variant ID Type Subtype PubMed ID
esv34070 CNV loss 18971310
nsv1036996 CNV gain 25217958
nsv1070213 CNV deletion 25765185
nsv1130912 CNV deletion 24896259
nsv1154054 CNV deletion 26484159
nsv832768 CNV gain 17160897
nsv832769 CNV loss 17160897

Variation tolerance for EGLN3 Gene

Residual Variation Intolerance Score: 24% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.88; 18.40% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for EGLN3 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
EGLN3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for EGLN3 Gene

Disorders for EGLN3 Gene

MalaCards: The human disease database

(3) MalaCards diseases for EGLN3 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
hypoxia
chronic mountain sickness
renal cell carcinoma
  • renal cell carcinoma, clear cell, somatic
- elite association - COSMIC cancer census association via MalaCards
Search EGLN3 in MalaCards View complete list of genes associated with diseases

Relevant External Links for EGLN3

Genetic Association Database (GAD)
EGLN3
Human Genome Epidemiology (HuGE) Navigator
EGLN3
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
EGLN3
genes like me logo Genes that share disorders with EGLN3: view

No data available for UniProtKB/Swiss-Prot and Genatlas for EGLN3 Gene

Publications for EGLN3 Gene

  1. Oxygen-regulated beta(2)-adrenergic receptor hydroxylation by EGLN3 and ubiquitylation by pVHL. (PMID: 19584355) Xie L. … Stamler J.S. (Sci. Signal. 2009) 3 4 22 64
  2. Differential function of the prolyl hydroxylases PHD1, PHD2, and PHD3 in the regulation of hypoxia-inducible factor. (PMID: 15247232) Appelhoff R.J. … Gleadle J.M. (J. Biol. Chem. 2004) 3 4 22 64
  3. Intracellular localisation of human HIF-1 alpha hydroxylases: implications for oxygen sensing. (PMID: 12615973) Metzen E. … Fandrey J. (J. Cell Sci. 2003) 3 4 22 64
  4. Differential regulation of HIF-1alpha prolyl-4-hydroxylase genes by hypoxia in human cardiovascular cells. (PMID: 12670503) Cioffi C.L. … Bowen B.R. (Biochem. Biophys. Res. Commun. 2003) 3 4 22 64
  5. Characterization and comparative analysis of the EGLN gene family. (PMID: 11574160) Taylor M.S. (Gene 2001) 3 4 22 64

Products for EGLN3 Gene

  • Addgene plasmids for EGLN3

Sources for EGLN3 Gene

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