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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

EGFR Gene

protein-coding   GIFtS: 79
GCID: GC07P055054

epidermal growth factor receptor

(Previous name: epidermal growth factor receptor (avian erythroblastic...)
(Previous symbol: ERBB)
 Explore 326 diseases affiliated with
EGFR via
MalaCards
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 Human Malady Compendium 
Biological research products
for EGFR    

Aliases
for EGFR gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Epidermal Growth Factor Receptor1 2     Epidermal Growth Factor Receptor (Avian Erythroblastic Leukemia Viral (V-Erb-B)
Oncogene Homolog)1
ERBB1 2 3     PIG612
ERBB11 2 3     Avian Erythroblastic Leukemia Viral (V-Erb-B) Oncogene Homolog2
Proto-Oncogene C-ErbB-12 3     Cell Growth Inhibiting Protein 402
Receptor Tyrosine-Protein Kinase ErbB-12 3     Cell Proliferation-Inducing Protein 612
HER12 3     MENA1
EC 2.7.10.13 8     EC 2.7.108

External Ids:    HGNC: 32361   Entrez Gene: 19562   Ensembl: ENSG000001466487   OMIM: 1315505   UniProtKB: P005333   

Export aliases for EGFR gene to outside databases

Previous GC identifers: GC07P054550 GC07P054794 GC07P054828 GC07P054860


Summaries
for EGFR gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for EGFR:
The protein encoded by this gene is a transmembrane glycoprotein that is a member of the protein kinase superfamily.
This protein is a receptor for members of the epidermal growth factor family. EGFR is a cell surface protein that
binds to epidermal growth factor. Binding of the protein to a ligand induces receptor dimerization and tyrosine
autophosphorylation and leads to cell proliferation. Mutations in this gene are associated with lung cancer. Multiple
alternatively spliced transcript variants that encode different protein isoforms have been found for this gene.
(provided by RefSeq, Jul 2010)

UniProtKB/Swiss-Prot: EGFR_HUMAN, P00533
Function: Receptor tyrosine kinase binding ligands of the EGF family and activating several signaling cascades to
convert extracellular cues into appropriate cellular responses. Known ligands include EGF, TGFA/TGF-alpha,
amphiregulin, epigen/EPGN, BTC/betacellulin, epiregulin/EREG and HBEGF/heparin-binding EGF. Ligand binding triggers
receptor homo- and/or heterodimerization and autophosphorylation on key cytoplasmic residues. The phosphorylated
receptor recruits adapter proteins like GRB2 which in turn activates complex downstream signaling cascades. Activates
at least 4 major downstream signaling cascades including the RAS-RAF-MEK-ERK, PI3 kinase-AKT, PLCgamma-PKC and STATs
modules. May also activate the NF-kappa-B signaling cascade. Also directly phosphorylates other proteins like RGS16,
activating its GTPase activity and probably coupling the EGF receptor signaling to the G protein-coupled receptor
signaling. Also phosphorylates MUC1 and increases its interaction with SRC and CTNNB1/beta-catenin
Function: Isoform 2 may act as an antagonist of EGF action

summary for EGFR:
The epidermal growth factor receptor (EGFR) is a receptor tyrosine kinase of the ErbB family. Four members
of the ErbB family have been identified; EGFR (ErbB1, HER1), ErbB2 (HER2), ErbB3 (HER3) and ErbB4 (HER4).
EGFR signaling is initiated by ligand binding to the extracellular ligand binding domain. This initiates
receptor homo-/hetero-dimerization and autophosphorylation by the intracellular kinase domain, resulting in
receptor activation. Following activation, phosphorylation of cytoplasmic substrates occurs and a signaling
cascade is initiated that drives many cellular responses, including changes in gene expression, cytoskeletal
rearrangement, anti-apoptosis and increased cell proliferation.

Gene Wiki entry for EGFR (Epidermal growth factor receptor)

PharmGKB "VIP" summary for EGFR


Genomic Views
for EGFR gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000007.13  NC_018918.1  NT_033968.6  NT_079592.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the EGFR gene promoter:
         Max1   p53   STAT3   c-Myc   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 6): EGFR promoter sequence
   Search SABiosciences Chromatin IP Primers for EGFR

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat EGFR


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 7p12   Ensembl cytogenetic band:  7p11.2   HGNC cytogenetic band: 7p12

EGFR Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
EGFR gene location

GeneLoc information about chromosome 7         GeneLoc Exon Structure

GeneLoc location for GC07P055054:  view genomic region     (about GC identifiers)

Start:
 55,086,714 bp from pter      End:
 55,324,313 bp from pter
Size:
 237,600 bases      Orientation:
 plus strand

1 alternative location:
Chr7+,CRA_TCAG 55,092,507-55,280,831     

Proteins
for EGFR gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: EGFR_HUMAN, P00533 (See protein sequence)
Recommended Name: Epidermal growth factor receptor precursor  
Size: 1210 amino acids; 134277 Da
Subunit: Binding of the ligand triggers homo- and/or heterodimerization of the receptor triggering its
autophosphorylation. Heterodimer with ERBB2. Interacts with ERRFI1; inhibits dimerization of the kinase domain and
autophosphorylation. Part of a complex with ERBB2 and either PIK3C2A or PIK3C2B. Interacts with GRB2; an adapter
protein coupling the receptor to downstream signaling pathways. Interacts with GAB2; involved in signaling downstream
of EGFR. Interacts with STAT3; mediates EGFR downstream signaling in cell proliferation. Interacts with RIPK1;
involved in NF-kappa-B activation. Interacts (autophosphorylated) with CBL; involved in EGFR ubiquitination and
regulation. Interacts with SOCS5; regulates EGFR degradation through TCEB1- and TCEB2-mediated ubiquitination and
proteasomal degradation. Interacts with PRMT5; methylates EGFR and enhances interaction with PTPN6. Interacts
(phosphorylated) with PTPN6; inhibits EGFR-dependent activation of MAPK/ERK. Interacts with COPG1; essential for
regulation of EGF-dependent nuclear transport of EGFR by retrograde trafficking from the Golgi to the ER. Interacts
with TNK2; this interaction is dependent on EGF stimulation and kinase activity of EGFR. Interacts with PCNA;
positively regulates PCNA. Interacts with PELP1. Interacts with MUC1. Interacts with AP2M1. Interacts with FER. May
interact with EPS8; mediates EPS8 phosphorylation. Interacts (via SH2 domains) with GRB2, NCK1 and NCK2. Interacts
with ATX2. Interacts with GAREM
Subcellular location: Cell membrane; Single-pass type I membrane protein. Endoplasmic reticulum membrane; Single-pass
type I membrane protein. Golgi apparatus membrane; Single-pass type I membrane protein. Nucleus membrane; Single-pass
type I membrane protein. Endosome. Endosome membrane. Note=In response to EGF, translocated from the cell membrane to
the nucleus via Golgi and ER. Endocytosed upon activation by ligand
Subcellular location: Isoform 2: Secreted
6/75 PDB 3D structures from and Proteopedia for EGFR (see all 75):
1DNQ (3D)        1DNR (3D)        1IVO (3D)        1M14 (3D)        1M17 (3D)        1MOX (3D)    
Secondary accessions: O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7
Q9UMD8 Q9UMG5
Alternative splicing: 4 isoforms:  P00533-1   P00533-2   P00533-3   P00533-4   

Explore the universe of human proteins at neXtProt for EGFR: NX_P00533

Post-translational modifications:

  • Phosphorylation at Ser-695 is partial and occurs only if Thr-693 is phosphorylated. Phosphorylation at Thr-678 and
    • Thr-693 by PRKD1 inhibits EGF-induced MAPK8/JNK1 activation. Dephosphorylation by PTPRJ prevents endocytosis and
    stabilizes the receptor at the plasma membrane. Autophosphorylation at Tyr-1197 is stimulated by methylation at
    Arg-1199 and enhances interaction with PTPN6. Autophosphorylation at Tyr-1092 and/or Tyr-1110 recruits STAT31
  • Monoubiquitinated and polyubiquitinated upon EGF stimulation; which does not affect tyrosine kinase activity or
    • signaling capacity but may play a role in lysosomal targeting. Polyubiquitin linkage is mainly through 'Lys-63', but
    linkage through 'Lys-48', 'Lys-11' and 'Lys-29' also occur. Deubiquitinated by OTUD7B, preventing degradation1
  • Methylated. Methylation at Arg-1199 by PRMT5 positively stimulates phosphorylation at Tyr-11971
  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_P00533

    • 4/27 DME Specific Peptides for EGFR (P00533) (see all 27)
     KPYDGIP  YGVTVWE  RDLAARN  RYLVIQG 

    EGFR Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins (4 alternative transcripts): 
    NP_005219.2  NP_958439.1  NP_958440.1  NP_958441.1  

    ENSEMBL proteins: 
     ENSP00000415559   ENSP00000342376   ENSP00000345973   ENSP00000413843   ENSP00000275493  
     ENSP00000413354   ENSP00000410031   ENSP00000395243  
    Reactome Protein details: P00533
    Human Recombinant Protein Products: 
    EMD Millipore Purified and/or Recombinant EGFR Protein
    R&D Systems Recombinant & Natural Proteins for EGFR (EGF R/ErbB1)
    Enzo Life Sciences proteins for EGFR
    OriGene Purified Proteins (see all 4): EGFR
    OriGene Protein Over-expression Lysate: EGFR
    OriGene Custom Protein Services for EGFR 
    GenScript Custom Purified and Recombinant Proteins Services for EGFR
    Novus Biologicals EGFR Proteins
    Novus Biologicals EGFR Lysates
    Sino Biological Recombinant Protein for EGFR
    ProSpec Recombinant Protein for EGFR
    Uscn Proteins for EGFR

    Gene Ontology (GO): 5/18 cellular component terms (GO ID links to tree view) (see all 18):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000139Golgi membrane IEA--
    GO:0005615extracellular space NAS9103388
    GO:0005622intracellular ----
    GO:0005634nucleus IDA17115032
    GO:0005737cytoplasm IDA--


    EGFR for ontologies           About GeneDecksing



    EGFR Antibody Products: 
    EMD Millipore Mono- and Polyclonal Antibodies for the study of EGFR
    R&D Systems Antibodies for EGFR (EGF R/ErbB1)
    Cell Signaling Technology (CST) Antibodies for EGFR 
    OriGene Antibodies (see all 17): EGFR
    OriGene Custom Antibody Services for EGFR 
    GenScript Superior Antibodies for EGFR
    Novus Biologicals EGFR Antibodies
    Abcam antibodies for EGFR 
    Uscn Antibodies for EGFR
    ThermoFisher Antibody for EGFR

    Assay Products for EGFR: 
    EMD Millipore Kits and Assays for the Analysis of EGFR
    OriGene Custom Immunoassay Development
    Browse OriGene Fluorogenic Cell Assay Kits
    R&D Systems ELISAs for EGFR (EGF R/ErbB1)         (see all)
    GenScript EGFR-Activity-based Kinase Assay for Compound Screening
    Cell Signaling Technology (CST) Sandwich ELISA Kits for EGFR
    Browse Enzo Life Sciences for kits & assays
    Uscn ELISAs and CLIAs for EGFR

    Protein Domains /
    Families
    for EGFR gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    EGFR for domains           About GeneDecksing

    5/11 InterPro domains/families (see all 11):
     IPR017441 Protein_kinase_ATP_BS
     IPR006212 Furin_repeat
     IPR000494 EGF_rcpt_L
     IPR001245 Ser-Thr/Tyr_kinase_cat_dom
     IPR009030 Growth_fac_rcpt

    Graphical View of Domain Structure for InterPro Entry P00533

    ProtoNet protein and cluster: P00533

    4 Blocks protein families:
    IPB000494 Epidermal growth-factor receptor (EGFR)
    IPB006211 Furin-like cysteine rich region
    IPB006212 Furin-like repeat
    IPB008266 Tyrosine protein kinase


    UniProtKB/Swiss-Prot: EGFR_HUMAN, P00533
    Similarity: Belongs to the protein kinase superfamily. Tyr protein kinase family. EGF receptor subfamily
    Similarity: Contains 1 protein kinase domain


    Function
    for EGFR gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: EGFR_HUMAN, P00533
    Function: Receptor tyrosine kinase binding ligands of the EGF family and activating several signaling cascades to
    convert extracellular cues into appropriate cellular responses. Known ligands include EGF, TGFA/TGF-alpha,
    amphiregulin, epigen/EPGN, BTC/betacellulin, epiregulin/EREG and HBEGF/heparin-binding EGF. Ligand binding triggers
    receptor homo- and/or heterodimerization and autophosphorylation on key cytoplasmic residues. The phosphorylated
    receptor recruits adapter proteins like GRB2 which in turn activates complex downstream signaling cascades. Activates
    at least 4 major downstream signaling cascades including the RAS-RAF-MEK-ERK, PI3 kinase-AKT, PLCgamma-PKC and STATs
    modules. May also activate the NF-kappa-B signaling cascade. Also directly phosphorylates other proteins like RGS16,
    activating its GTPase activity and probably coupling the EGF receptor signaling to the G protein-coupled receptor
    signaling. Also phosphorylates MUC1 and increases its interaction with SRC and CTNNB1/beta-catenin
    Function: Isoform 2 may act as an antagonist of EGF action
    Catalytic activity: ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate
    Enzyme regulation: Endocytosis and inhibition of the activated EGFR by phosphatases like PTPRJ and PTPRK constitute
    immediate regulatory mechanisms. Upon EGF-binding phosphorylates EPS15 that regulates EGFR endocytosis and activity.
    Moreover, inducible feedback inhibitors including LRIG1, SOCS4, SOCS5 and ERRFI1 constitute alternative regulatory
    mechanisms for the EGFR signaling

         Genatlas biochemistry entry for EGFR:
    epidermal growth factor receptor,also binding transforming growth factor alpha (TGFA),involved in early craniofacial
    development and palate closure,phosphorylating GJB1,amplified in prostate carcinoma and in astrocytomas,deleted in
    glioblastomas and mutated in malignant oral keratinocytes

    Enzyme Numbers (IUBMB): EC 2.7.10.11 2 EC 2.7.102

    miRNA
    Products:            		miRTarBase miRNAs that target EGFR:
    hsa-mir-146a (MIRT004730), hsa-mir-21 (MIRT005807), hsa-mir-7 (MIRT002289), hsa-mir-16 (MIRT001470), hsa-mir-128 (MIRT004353), hsa-mir-1 (MIRT001370)

    OriGene 3'-UTR Clone (see all 4): EGFR
    Browse MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat EGFR
    8/17 QIAGEN miScript miRNA Assays for microRNAs that regulate EGFR (see all 17):
    hsa-miR-579 hsa-miR-607 hsa-miR-186* hsa-miR-586 hsa-miR-875-5p hsa-miR-27a hsa-miR-548o hsa-miR-545
    SwitchGear 3'UTR luciferase reporter plasmid: EGFR 3' UTR sequence
    Inhib. RNA
    Products:            		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for EGFR (see all 7)
    OriGene shRNA RFP: EGFR
    OriGene siRNA: EGFR
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat EGFR

    Gene Editing
    Products:    		DNA2.0 Custom Protein Engineering Service for EGFR

    Clone
    Products:             		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for EGFR (see all 11)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for EGFR (see all 4)
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector (see all 4): EGFR (NM_201282)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for EGFR
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat EGFR 

    Cell Line
    Products:             		GenScript Custom overexpressing Cell Line Services for EGFR
    Search LifeMap BioReagents cell lines for EGFR

    In Situ Assay
    Products:       
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for EGFR

    Gene Ontology (GO): 5/17 molecular function terms (GO ID links to tree view) (see all 17):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003690double-stranded DNA binding NAS6325948
    GO:0004709MAP kinase kinase kinase activity NAS15542601
    GO:0004713protein tyrosine kinase activity TAS--
    GO:0004714transmembrane receptor protein tyrosine kinase activity TAS--
    GO:0004716receptor signaling protein tyrosine kinase activity IEA--


    EGFR for ontologies           About GeneDecksing


    6 GenomeRNAi human phenotypes for EGFR:
     Decreased focal adhesion (FA)   Decreased p24 protein expressi  Decreased substrate adherent c  Decreased viability with pacli 
     Increased S DNA content  Increased cell death HMECs cel 

    Animal Models:
         Mouse knock-outs for EGFR: Egfrtm1Arge Egfrtm1Rdk Egfrtm1.1Dwt Egfrtm1Mag
         15/27 MGI mutant phenotypes (inferred from 14 alleles) (MGI details for Egfr) (see all 27):
     adipose tissue  cardiovascular system  cellular  craniofacial  digestive/alimentary 
     embryogenesis  endocrine/exocrine gland  growth/size  hearing/vestibular/ear  hematopoietic system 
     homeostasis/metabolism  immune system  integument  limbs/digits/tail  liver/biliary system 

    EGFR for phenotypes           About GeneDecksing


    Pathways & Interactions
    for EGFR gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways - 5/102 super-pathways (see all 102) About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Apoptotic Pathways in Synovial Fibroblasts
    8/13 pathways (see all 13)
    		Apoptotic Pathways in Synovial Fibroblasts1.00
    		ERK5 Signaling0.61
    		p53 Mediated Apoptosis0.84
    		eIF2 Pathway0.60
    		Mitochondrial Apoptosis0.73
    		Rac1 Pathway0.58
    		Telomerase Components in Cell Signaling0.72
    		Nuclear Receptor Activation by Vitamin-A0.57
    2Signaling by FGFR
    8/12 pathways (see all 12)
    		Signaling by FGFR1.00
    		DAP12 signaling0.83
    		Downstream signaling of activated FGFR0.92
    		Signaling by EGFR in Cancer0.83
    		Signaling by FGFR in disease0.91
    		DAP12 interactions0.76
    		Signaling by ERBB20.89
    		Signaling by PDGF0.72
    3PIP3 activates AKT signaling
    8/10 pathways (see all 10)
    		PI-3K cascade1.00
    		PI3K/AKT activation0.97
    		PIP3 activates AKT signaling1.00
    		GAB1 signalosome0.96
    		PI3K/AKT Signaling in Cancer1.00
    		Constitutive PI3K/AKT Signaling in Cancer0.88
    		PI3K events in ERBB2 signaling1.00
    		Signaling by SCF-KIT0.72
    4GPCR Pathway
    		GPCR Pathway1.00
    		Estrogen Pathway0.55
    		Ras Pathway0.62
    		Pancreatic Adenocarcinoma0.55
    		Breast Cancer Regulation by Stathmin10.58
    		Paxillin Interactions0.53
    		NFAT in Immune Response0.58
    		P2Y Receptor Signaling0.38
    5Development_CNTF receptor signaling
    		Cell adhesion_PLAU signaling0.35
    		Translation Regulation activity of EIF4F0.32
    		Cell adhesion PLAU signaling0.35
    		Translation _Regulation of EIF2 activity0.25
    		Translation _Regulation of EIF4F activity0.32
    		Translation Regulation activity of EIF20.25

    Pathway sources
    See GeneCards unified pathways
    Show all pathways

    5/22 EMD Millipore Pathways for EGFR (see all 22)
        Transcription Androgen Receptor nuclear signaling
    Cell adhesion PLAU signaling
    Development Ligand-independent activation of ESR1 and ESR2
    Development EGFR signaling via PIP3
    Translation Regulation activity of EIF2

    5/78 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for EGFR (see all 78)
        Telomerase Components in Cell Signaling
    UVB-Induced MAPK Signaling
    Molecular Mechanisms of Cancer
    eIF2 Pathway
    Intracellular Calcium Signaling

    1 Cell Signaling Technology (CST) Pathway for EGFR
        Tyrosine Kinases / Adaptors

    4 Tocris Bioscience Pathways for EGFR
        Akt Pathway
    Apoptosis Pathway
    NF-kappaB Pathway
    MAPK Pathway

    5/24 GeneGo (Thomson Reuters) Pathways for EGFR (see all 24)
        Development Endothelin-1/EDNRA transactivation of EGFR
    Development EGFR signaling pathway
    Mucin expression in CF via TLRs, EGFR signaling pathways
    Development ERBB-family signaling
    Cell adhesion PLAU signaling

    5/29 BioSystems Pathways for EGFR (see all 29) 
        Focal Adhesion
    EGFR1 Signaling Pathway
    ErbB signaling pathway
    MAPK signaling pathway
    Signaling Pathways in Glioblastoma

    5/45        Reactome Pathways for EGFR (see all 45)
        L1CAM interactions
    Signaling by EGFR in Cancer
    EGFR Transactivation by Gastrin
    Signal transduction by L1
    Mature HBEGF binds to EGFR, triggering dimerisation and autophosphorylation of the receptor

    3 PharmGKB Pathways for EGFR
        EGFR Inhibitor Pathway, Pharmacodynamics
    Erlotinib Pathway, Pharmacokinetics
    Vemurafenib Pathway, Pharmacodynamics

    5/21         Kegg Pathways  (Kegg details for EGFR) (see all 21):
        MAPK signaling pathway
    ErbB signaling pathway
    Calcium signaling pathway
    Cytokine-cytokine receptor interaction
    Endocytosis


    EGFR for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for EGFR

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/703 Interacting proteins for EGFR (P005331, 2, 3 ENSP000002754934) via UniProtKB, MINT, STRING, and/or I2D (see all 703)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    GRB2P629931, 2, 3, ENSP000003390074EBI-297353,EBI-401755 MINT-8029342 MINT-8029357 MINT-74541 MINT-61494 MINT-8029326 MINT-58642 MINT-8029310 MINT-1793777 MINT-61502 MINT-8029261 MINT-61540 MINT-8038388 MINT-6169986 MINT-61498 MINT-8038373 MINT-8401377 MINT-61500 MINT-58641 MINT-61496 MINT-8029372 MINT-6805737 MINT-58640 MINT-61497 MINT-8029231 I2D: score=8 STRING: ENSP00000339007
    SHC1P293531, 2, 3, ENSP000004013034EBI-297353,EBI-78835 MINT-74727 MINT-74729 MINT-8038549 MINT-74731 MINT-1782377 MINT-61491 MINT-8038504 MINT-1782352 MINT-74732 MINT-61499 MINT-8401401 MINT-8038534 MINT-61501 MINT-74730 MINT-17353 MINT-8401377 MINT-61495 MINT-61482 MINT-74728 MINT-61503 MINT-61489 MINT-8038489 MINT-8038564 I2D: score=10 STRING: ENSP00000401303
    CBLP226811, 2, 3, ENSP000002640334EBI-297353,EBI-518228 MINT-6170185 MINT-16158 MINT-6539293 MINT-6539009 MINT-6539329 MINT-61493 MINT-6539305 MINT-6538916 MINT-6539317 MINT-6539560 MINT-6539574 MINT-6170566 MINT-60973 MINT-7046383 MINT-6539341 MINT-60972 I2D: score=9 STRING: ENSP00000264033
    EGFP011331, 2, 3, ENSP000002651714EBI-297353,EBI-640857 MINT-8146350 MINT-8146425 MINT-25095 MINT-8146487 MINT-8146461 MINT-8146623 MINT-8146300 MINT-8146514 MINT-8146500 MINT-8146380 MINT-8146287 MINT-6169912 I2D: score=6 STRING: ENSP00000265171
    HIST1H3HP684313, ENSP000003581604I2D: score=1 STRING: ENSP00000358160
    About this table

    Gene Ontology (GO): 5/42 biological process terms (GO ID links to tree view) (see all 42):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000165MAPK cascade NAS15542601
    GO:0000186activation of MAPKK activity NAS15542601
    GO:0000902cell morphogenesis ----
    GO:0001503ossification NAS12925580
    GO:0001892embryonic placenta development IEA--


    EGFR for ontologies           About GeneDecksing



    Drugs & Compounds
    for EGFR gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    EGFR for compounds           About GeneDecksing

    EMD Millipore small molecules for EGFR:
    Small Molecule - inhibitor
    Enzo Life Sciences drugs & compounds for EGFR

    Compounds for EGFR available from Tocris Bioscience    About this table
    CompoundAction CAS #
    Iressa Orally active, selective EGFR inhibitor [184475-35-2]
    JNJ 28871063 hydrochloridePotent ErbB receptor family inhibitor[944341-54-2]
    PD 153035 hydrochlorideEGFR-kinase inhibitor[153436-54-5]
    AG 1478 hydrochlorideHighly potent EGFR-kinase inhibitor[153436-53-4]

    4 HMDB Compounds for EGFR    About this table
    CompoundSynonyms CAS #PubMed Ids
    Aldosterone(+)-Aldosterone (see all 22)52-39-117681751
    ADPadenosindiphosphorsaeure (see all 8)58-64-0--
    Adenosine triphosphate5'-(tetrahydrogen triphosphate) Adenosine (see all 24)56-65-5--
    L-Tyrosine(-)-a-Amino-p-hydroxyhydrocinnamate (see all 28)60-18-4--

    10 DrugBank Compounds for EGFR    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    LapatinibFMM (see all 5)388082-78-8targetantagonist15163842 14751502 16894399 20110044 12214266 18803986 14967461 14737100 11752352 20658522 15374980 14633707
    Panitumumab-- 339177-26-3targetsuppressor12620146 11894013 20481659 18343240 16012181 14967460 18503402 16857825 17355997 11752352 20623992 11255078
    CetuximabAnti EGFR (see all 2)205923-56-4targetantagonist10480573 11408594 11752352 11431346 10628369 10601294
    Erlotinib-- 183321-74-6targetantagonist12517254 12814826 12820772 11752352 12840797 12498017
    Gefitinib-- 184475-35-2targetantagonist11585753 11566608 11752352 11522647 10815932 11673690
    FlavopiridolAlvocidib (see all 5)131740-09-5target--11752352
    LidocaineDilocaine (see all 2)137-58-6targetantagonist16551906
    N-[4-(3-BROMO-PHENYLAMINO)-QUINAZOLIN-6-YL]-ACRYLAMIDE-- --target--10592235
    S-{3-[(4-ANILINOQUINAZOLIN-6-YL)AMINO]-3-OXOPROPYL}-L-CYSTEINE-- --target--10592235
    TrastuzumabAnti HER2 (see all 2)180288-69-1target--11752352

    10/119 Novoseek chemical compound relationships for EGFR gene (see all 119)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    gefitinib 97.2 2922 17361439 (8), 16106023 (7), 16818686 (7), 16956694 (7) (see all 99)
    erlotinib 96.4 1156 16818686 (7), 17453292 (7), 16928826 (6), 19130057 (6) (see all 99)
    cetuximab 95.9 1196 12850474 (7), 16106023 (7), 20010090 (6), 17531336 (6) (see all 99)
    tyrosine 93.9 4999 16263724 (9), 16287490 (8), 12589790 (7), 10068444 (6) (see all 99)
    ag 1478 93.3 467 14676326 (5), 19947936 (5), 17092939 (4), 19816982 (4) (see all 99)
    panitumumab 92 186 17671148 (2), 18086972 (2), 20044619 (2), 18343240 (2) (see all 99)
    lapatinib 88.2 334 17635524 (6), 18644997 (5), 18199554 (5), 19529774 (4) (see all 99)
    pd153035 88 105 16211241 (2), 17934341 (2), 10473113 (2), 15562758 (2) (see all 60)
    zd6474 85.6 171 15604279 (8), 12684431 (5), 17145834 (4), 16688779 (3) (see all 67)
    trastuzumab 85.3 164 19188134 (5), 16161043 (4), 17622245 (4), 16163699 (2) (see all 95)

    10/11 PharmGKB related drug/compound annotations for EGFR gene (see all 11)
    Drug/compound PharmGKB Annotation
    Alkylating AgentsCA  
    carboplatinCA  
    cetuximabCA  DL  
    docetaxelCA  
    egfr inhibitorsCA  
    erlotinibCA  DL  
    gefitinibCA  DL  
    geldanamycinCA  
    gemcitabineCA  
    paclitaxelCA  
    About this table

    Search CenterWatch for drugs/clinical trials and news about EGFR 

    Transcripts
    for EGFR gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for EGFR gene (4 alternative transcripts): 
    NM_005228.3  NM_201282.1  NM_201283.1  NM_201284.1  

    Unigene Cluster for EGFR:

    Epidermal growth factor receptor
    Hs.488293  [show with all ESTs]
    Unigene Representative Sequence: NM_005228
    11 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000455089(uc022adm.1 uc010kzg.2 uc022ado.1) ENST00000342916(uc003tqi.3)
    ENST00000344576(uc003tqj.3) ENST00000420316(uc003tqh.3) ENST00000275493(uc003tqk.3 uc022adn.1 uc011kco.2)
    ENST00000459688 ENST00000463948 ENST00000450046 ENST00000485503 ENST00000442591(uc011kcq.1 uc011kcp.1)
    ENST00000454757

    miRNA
    Products:             		 OriGene 3'-UTR Clone (see all 4): EGFR
    Browse OriGene MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat EGFR
    8/17 QIAGEN miScript miRNA Assays for microRNAs that regulate EGFR (see all 17):
    hsa-miR-579 hsa-miR-607 hsa-miR-186* hsa-miR-586 hsa-miR-875-5p hsa-miR-27a hsa-miR-548o hsa-miR-545
    SwitchGear 3'UTR luciferase reporter plasmid: EGFR 3' UTR sequence
    Inhib. RNA
    Products:             		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for EGFR (see all 7)
    OriGene shRNA RFP: EGFR
    OriGene siRNA: EGFR
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat EGFR
    Clone
    Products:             		 OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for EGFR (see all 11)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for EGFR (see all 4)
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector (see all 4): EGFR (NM_201282)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for EGFR
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat EGFR 
    Primer
    Products:            		 OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for EGFR
    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat EGFR
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat EGFR
      Search QIAGEN QuantiFast Probe-based Assays in human, mouse, rat EGFR

    Additional cDNA sequence: 

    AB209442.1 AF125253.1 AF277897.1 AK225422.1 AK290352.1 AK294750.1 AY550966.1 AY698023.1 
    AY698024.1 BC070081.1 BC094761.1 BC118665.1 BC128419.1 BC134346.1 DQ088980.1 EF210210.1 
    EF210211.1 GU255993.1 HM437234.1 HM437235.1 HQ730875.1 HQ912715.1 HQ999997.1 K03193.1 
    U48722.1 U95089.1 X00588.1 X00663.1 

    21 DOTS entries:

    DT.97784849  DT.453606  DT.121058602  DT.86855651  DT.95165593  DT.101978019  DT.92446350  DT.100752430 
    DT.121058582  DT.91654361  DT.121058480  DT.121058532  DT.121058546  DT.121058650  DT.418647  DT.95254161 
    DT.97822681  DT.91963338  DT.95095929  DT.95165591  DT.95229256 

    24/484 AceView cDNA sequences (see all 484):

    CB269761 BQ575631 AI278317 BC070081 AW275823 AI336141 AL040990 BM747582 
    BF992436 AA463742 AI217671 NM_201282 BG619090 X00663 BX108964 BM715282 
    AI950585 H80439 CA436447 BX378635 BQ637472 AI301624 CB131985 NM_201283 

    GeneLoc Exon Structure


    Expression
    for EGFR gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    EGFR expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: CCCGCATTAG

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    EGFR expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    10/19 LifeMap In Vivo Development Anatomical Compartments/Cells (see all 19) 
    Tissue Anatomical Compartment CellCategory (developmental path)
    AdiposeVascular AdiposeStromal Vascular Preadipocyte Progenitor CellsAdipose
    HeartSemilunar ValvesSemilunar Valve CellsEndocardium, Neural Crest
    PlacentaExtravillous Cytotrophoblast LayerExtravillous Cytotrophoblast CellsExtraembryonic Tissues, Placenta
    Early Embryo (Zygote)Morula8-Cell EmbryoEarly Embryo
    Early Embryo (Zygote)ZygoteZygoteEarly Embryo
    HeartAtrioventricular Endocardial CushionEndocardial Cushion CellsEndocardium
    HeartEndocardiumEndocardial CellsEndocardium
    OvaryAntral FollicleCumulus CellsOvary
    EyeInner Nuclear LayernGnG Amacrine CellsAmacrine, Retina
    LimbZeugopodMesenchymal Condensate CellsBone, Cartilage
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization
    Stem Cell Differentiation: 1 LifeMap Cell 
    NameCategory
    PureStem™ mesenchymal progenitor 7SMOO32 (Embryonic Progenitor Cell)Adipose, Bone, Cartilage

    See EGFR Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for EGFR

    SOURCE GeneReport for Unigene cluster: Hs.488293

    UniProtKB/Swiss-Prot: EGFR_HUMAN, P00533
    Tissue specificity: Ubiquitously expressed. Isoform 2 is also expressed in ovarian cancers

        SABiosciences Expression via Pathway-Focused PCR Arrays including EGFR (see all 24): 
              Lung Cancer in human mouse rat
              Wound Healing in human mouse rat
              Nitric Oxide Signaling Pathway in human mouse rat
              Prostate Cancer in human mouse rat
              Cell Motility in human mouse rat

    Primer
    Products:    		 OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for EGFR
    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat EGFR
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat EGFR
    Search QIAGEN QuantiFast Probe-based Assays in human, mouse, rat EGFR
    In Situ
    Assay Products:     
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for EGFR

    Orthologs
    for EGFR gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of animals.

    Orthologs for EGFR gene from 5/17 species (see all 17)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    chicken
    (Gallus gallus)    		 Aves EGFR1 epidermal growth factor receptor 73.88(n)
    78.29(a)    		   396494  NM_205497.2  NP_990828.2 
    lizard
    (Anolis carolinensis)    		 Reptilia EGFR6
    		 --
    		 72(a)
    		 1 ↔ 1
    		 6(51109066-51161436)
    zebrafish
    (Danio rerio)    		 Actinopterygii egfr2 epidermal growth factor receptor 75.84(n)   378478  AY154658.1 
    fruit fly
    (Drosophila melanogaster)    		 Insecta Egfr3 eggshell pattern formation epidermal growth
    factor receptor less    		 40(a)     --
    worm
    (Caenorhabditis elegans)    		 Secernentea let-233 tyrosine-protein kinase (Epidermal growth
    factor receptor subfamily) less    		 29(a)   II(9197428-9206848)   --


    ENSEMBL Gene Tree for EGFR (if available)
    TreeFam Gene Tree for EGFR (if available) 

    Paralogs
    for EGFR gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for EGFR gene
    SYK2  TNK12  JAK22  JAK32  TNK22  TYK22  ERBB42  JAK12  
    ERBB32  PTK22  ERBB22  ZAP702  PTK2B2  
    18/47 SIMAP similar genes for EGFR using alignment to 29 protein entries:     EGFR_HUMAN (see all proteins) (see all similar genes):
    EPHA4    ERBB2    ERBB4    FLT4    MATK    ERBB3
    TXK    FGFR1    ABL1    RET/PTC2    DKFZp686M05208    c-erbB-3
    MAPK3    RPS6KA2    TNK2    HER-2    TYK2    JAK2

    EGFR for paralogs           About GeneDecksing



    Genomic Variants
    for EGFR gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/3860 NCBI SNPs in EGFR are shown (see all 3860)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 7 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs289294951,2
    		Cdrug-response55247498(+) TGCTGA/G/TGCTCC 3 S G C mis1 ese32NA 4
    rs1214345691,2
    		Cpathogenic55254862(+) CATCAC/TGCAGC 2 T M mis10--------
    rs1048860121,2
    		Cother55265277(+) ACACCA/G/TCAGCA 3 P syn11NA 4552
    rs1871425261,2
    		--55084909(+) CTAGTA/CATTCT 4 -- us2k10--------
    rs1407038361,2
    		--55084933(+) TGTTTC/GTTGTG 4 -- us2k10--------
    rs69654691,2
    		C,F,H,--55084967(+) ATATAC/TAAGCC 4 -- us2k123Minor allele frequency- T:0.07NS EA NA WA 3062
    rs1165935471,2
    		F,--55085029(+) TTCTTA/CCATGC 4 -- us2k11Minor allele frequency- C:0.03WA 118
    rs1431830691,2
    		--55085038(+) GCTGTC/TTTTTT 4 -- us2k10--------
    rs1511323701,2
    		--55085085(+) CAGTTA/GTAGCT 4 -- us2k10--------
    rs1912025091,2
    		--55085203(+) ATTGTA/TTTCAG 4 -- us2k10--------

    HapMap Linkage Disequilibrium report for EGFR (55086714 - 55324313 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 6 variations for EGFR
         3 CNVs: 62653 52258 64824
         3 Indels: 99957 12932 64823
    Human Gene Mutation Database (HGMD): EGFR

    5/56 SABiosciences Cancer Mutation PCR Assays for EGFR (see all 56):
    Cosmic IdAA Change
    13427p.E709A
    13551p.E746_T751>I
    6252p.G719S
    21687p.A289V
    21684p.T263P
    5/12 SABiosciences Cancer Mutation PCR Arrays containing EGFR (see all 12):
    Esophageal Cancer
    Cancer Comprehensive Panel 384HT
    Lung Cancer
    Oncogene Panel 384HT
    Receptor Tyrosine Kinase (RTK) (Panel I)
    4 SABiosciences qBiomarker Copy Number PCR Arrays containing EGFR:
    Oncogenes & Tumor Suppressor Genes 384HC
    Breast Cancer
    Lung Cancer
    Kinases & Phosphatases
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing EGFR
    DNA2.0 Custom Variant and Variant Library Synthesis for EGFR

    Disorders / Diseases
    for EGFR gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    EGFR for disorders           About GeneDecksing

    OMIM gene information: 131550   
    OMIM disorders: 211980  
    UniProtKB/Swiss-Prot: EGFR_HUMAN, P00533
  • Defects in EGFR are associated with lung cancer (LNCR) [MIM:211980]. LNCR is a common malignancy affecting
    • tissues of the lung. The most common form of lung cancer is non-small cell lung cancer (NSCLC) that can be divided
    into 3 major histologic subtypes: squamous cell carcinoma, adenocarcinoma, and large cell lung cancer. NSCLC is often
    diagnosed at an advanced stage and has a poor prognosis

    20/326 diseases for EGFR (see all 326):    About MalaCards
    nonsmall cell lung cancer, response to tyrosine kinase inhibitor in    adenocarcinoma of lung, response to tyrosine kinase inhibitor in    malignant peripheral nerve sheath tumor    lung cancer
    progesterone-receptor negative breast cancer    estrogen-receptor positive breast cancer    placental site trophoblastic tumor    lymphoepithelioma-like carcinoma
    squamous cell carcinoma    silver-russell syndrome    ring chromosome 7    middle ear cholesteatoma
    ethmoid sinusitis    peutz-jeghers syndrome    doxorubicin induced cardiomyopathy    microglandular adenosis
    ring chromosomes    leukemia    drug-induced hepatitis    invasive bladder transitional cell carcinoma

    11 diseases from the University of Copenhagen DISEASES database for EGFR:
    Lung cancer     Carcinoma     Breast cancer     Malignant glioma
    Colorectal cancer     Ovarian cancer     Pancreatic cancer     Prostate cancer
    Diarrhea     Urinary bladder cancer     Brain cancer

    10/97 Novoseek disease relationships for EGFR gene (see all 97)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    nsclc 91.1 3311 18710625 (7), 16106023 (6), 15777970 (6), 18347146 (6) (see all 99)
    tumors 87.7 6585 14967457 (9), 11727256 (8), 8151316 (8), 18450321 (8) (see all 99)
    glioblastoma 85 799 11511795 (7), 15618223 (6), 10728703 (6), 10029453 (5) (see all 99)
    cancer 84.6 2745 11597399 (7), 1717146 (5), 16378905 (5), 17827454 (5) (see all 99)
    cancer lung 84.4 1481 12720099 (7), 19331130 (6), 16226114 (6), 17876048 (5) (see all 99)
    carcinoma squamous cell 83.6 957 9828815 (5), 16550055 (5), 9816015 (5), 7970803 (5) (see all 99)
    adenocarcinoma lung 83.3 453 16357156 (5), 18508816 (5), 19130320 (5), 7599067 (4) (see all 99)
    breast cancer 82.5 1846 15095477 (8), 11859875 (8), 9066618 (6), 8960138 (6) (see all 99)
    glioblastoma multiforme 79.6 193 15746047 (4), 17236582 (4), 11504770 (4), 17679463 (3) (see all 99)
    adenocarcinoma 78.4 750 16449241 (11), 17321325 (5), 15211117 (5), 16052218 (5) (see all 99)

    Genatlas disease: EGFR
    glioblastoma,multiform (amplification of deleted/rearranged EGFR)

    Genetic Association Database (GAD): EGFR
    Human Genome Epidemiology (HuGE) Navigator: EGFR (572 documents)
    Tumor Gene Database (TGDB): EGFR

    Export disorders for EGFR gene to outside databases

    Publications
    for EGFR gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for EGFR gene, integrated from 9 sources (see all 7768):
    (articles sorted by number of sources associating them with EGFR)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. EGFR and erbB2 mutation status in Japanese lung cancer patients. (PubMed id 16003726)1, 4, 9 Sasaki H....Fujii Y. (2006)
    2. Epidermal growth factor receptor mutations in needle biopsy/aspiration samples predict response to gefitinib therapy and survival of patients with advanced nonsmall cell lung cancer. (PubMed id 16152581)1, 4, 9 Shih J.Y....Yang P.C. (2006)
    3. Predictive and prognostic impact of epidermal growth factor receptor mutation in non-small-cell lung cancer patients treated with gefitinib. (PubMed id 15710947)1, 4, 9 Han S.W....Kim N.K. (2005)
    4. Mutations of the epidermal growth factor receptor gene predict prolonged survival after gefitinib treatment in patients with non-small-cell lung cancer with postoperative recurrence. (PubMed id 15738541)1, 4, 9 Mitsudomi T....Yatabe Y. (2005)
    5. Mutations of epidermal growth factor receptor of non-small cell lung cancer were associated with sensitivity to gefitinib in recurrence after surgery. (PubMed id 16140420)1, 4, 9 Kondo M....Sekido Y. (2005)
    6. Mutations in the epidermal growth factor receptor gene are linked to smoking-independent, lung adenocarcinoma. (PubMed id 16052218)1, 4, 9 Sonobe M....Tanaka F. (2005)
    7. Activated Cdc42-associated kinase 1 is a component of EGF receptor signaling complex and regulates EGF receptor degradation. (PubMed id 17182860)1, 2, 9 Shen F.... Yang W. (2007)
    8. Distinct epidermal growth factor receptor and KRAS mutation patterns in non-small cell lung cancer patients with different tobacco exposure and clinicopathologic features. (PubMed id 16533793)1, 2, 9 Tam I.Y.S.... Wong M.P. (2006)
    9. EGFR Mutation status in Japanese lung cancer patients: genotyping analysis using LightCycler. (PubMed id 15837743)1, 4, 9 Sasaki H....Fujii Y. (2005)
    10. Glutathione S-transferase M1 gene but not insulin-like growth factor-2 gene or epidermal growth factor gene is associated with prostate cancer. (PubMed id 16018936)1, 4, 9 Lai M.T....Chen W.C. (2005)

    External Searches for EGFR gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing EGFR gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 1956 HGNC: 3236 AceView: EGFR Ensembl:ENSG00000146648 euGenes: HUgn1956
    ECgene: EGFR Kegg: 1956 H-InvDB: EGFR

    Other Databases showing EGFR gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing EGFR gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for EGFR Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for EGFR Genetics and Cytogenetics in Oncology and Haematology
    GeneReviewshttp://www.ncbi.nlm.nih.gov/sites/GeneTests/lab/gene/EGFR
    NIEHS-SNPshttp://egp.gs.washington.edu/data/egfr/
    Wikipedia http://en.wikipedia.org/wiki/Epidermal_growth_factor_receptor

    Intellectual Property
    for EGFR gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for EGFR gene:
    Search GeneIP for patents involving EGFR

    Licensable Technologies for EGFR gene:
    Weizmann Institute:Combination of Antibodies to EGFR
    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    for EGFR gene

    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences),
    In Situ Hybridization Assays from
    Advanced Cell Diagnostics
    About This Section

     EMD Millipore Purified and/or Recombinant EGFR Protein
     Browse for Gene Knock-down Tools from EMD Millipore
     Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
     EMD Millipore small molecules (inhibitor) for EGFR
     EMD Millipore Mono- and Polyclonal Antibodies for the study of EGFR
     EMD Millipore Kits and Assays for the Analysis of EGFR
     
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     Antibodies for EGFR (EGF R/ErbB1)   Browse Cell Culture Products  
     ELISAs for EGFR (EGF R/ErbB1)   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Kinase Activity Assays/Reagents  
     Browse ELISpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
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     Cell Selection/Detection Kits/Reagents for EGFR (EGF R/ErbB1)   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Phosphatase Activity Assays/Reagents   Recombinant/Natural Proteins for EGFR (EGF R/ErbB1)  
     OriGene Antibodies for EGFR   OriGene shRNA RFP for EGFR  
     OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for EGFR   OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for EGFR  
     OriGene Protein Over-expression Lysate for EGFR   Browse OriGene Fluorogenic Cell Assay Kits  
     OriGene siRNA for EGFR   OriGene 3'-UTR Clone for EGFR  
     OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for EGFR   OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for EGFR  
     Browse OriGene GFP tagged cDNA clones in CMV expression vector   Browse OriGene MicroRNA Expression Plasmids  
     Browse OriGene basic RS shRNAs   Browse OriGene validated miRNA SYBR primer pairs  
     OriGene Purified Protein for EGFR   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
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     QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat EGFR
     QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing EGFR
     QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat EGFR
     QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat EGFR
     Search QIAGEN QuantiFast Probe-based Assays in human, mouse, rat EGFR
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     GenScript Custom Purified and Recombinant Proteins Services for EGFR GenScript cDNA clones with any tag delivered in your preferred vector for EGFR
     GenScript EGFR-Activity-based Kinase Assay for Compound Screening GenScript Superior Antibodies for EGFR
     GenScript Custom overexpressing Cell Line Services for EGFR CloneReady with Over 120,000 Genes
     Gene Synthesis: Any Gene in Any Vector Vector-based siRNA and miRNA, Ready for Transfection
     Gene Mutant Library, Variants up to 10^11 Plasmid Preparation
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     Antibodies & Assays for EGFR 

     Regulatory tfbs in EGFR promoter
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     Tocris compounds for EGFR
     Proteins and Antibodies for EGFR
     Browse Sino Biological cDNA Clones
     Antibodies/Proteins Production Services
     Rabbit Monoclonal Antibody Platform
     Bulk Purchasing
     Drugs/Proteins for EGFR
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
     Novus Tissue Slides
     EGFR antibodies
     EGFR proteins
     EGFR lysates
     Antibodies for EGFR
     See all of Abcam's Antibodies, Kits and Proteins for EGFR
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Recombinant Protein for EGFR




     EGFR Proteins, Antibodies, CLIAs, and ELISAs
     Search LifeMap BioReagents cell lines for EGFR
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for EGFR
     SwitchGear 3'UTR luciferase reporter plasmids for EGFR
     SwitchGear Promoter luciferase reporter plasmids for EGFR
     ThermoFisher Antibody for EGFR
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat EGFR
           
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