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Aliases for EGFR Gene

Aliases for EGFR Gene

  • Epidermal Growth Factor Receptor 2 3
  • Receptor Tyrosine-Protein Kinase ErbB-1 3 4
  • Erb-B2 Receptor Tyrosine Kinase 1 2 3
  • Proto-Oncogene C-ErbB-1 3 4
  • EC 2.7.10.1 4 64
  • ERBB1 3 4
  • ERBB 3 4
  • HER1 3 4
  • Epidermal Growth Factor Receptor (Avian Erythroblastic Leukemia Viral (V-Erb-B) Oncogene Homolog) 2
  • Erythroblastic Leukemia Viral (V-Erb-B) Oncogene Homolog (Avian) 2
  • Avian Erythroblastic Leukemia Viral (V-Erb-B) Oncogene Homolog 3
  • Cell Proliferation-Inducing Protein 61 3
  • Cell Growth Inhibiting Protein 40 3
  • EC 2.7.10 64
  • NISBD2 3
  • PIG61 3
  • MENA 3

External Ids for EGFR Gene

Previous Symbols for EGFR Gene

  • ERBB

Summaries for EGFR Gene

Entrez Gene Summary for EGFR Gene

  • The protein encoded by this gene is a transmembrane glycoprotein that is a member of the protein kinase superfamily. This protein is a receptor for members of the epidermal growth factor family. EGFR is a cell surface protein that binds to epidermal growth factor. Binding of the protein to a ligand induces receptor dimerization and tyrosine autophosphorylation and leads to cell proliferation. Mutations in this gene are associated with lung cancer. Multiple alternatively spliced transcript variants that encode different protein isoforms have been found for this gene. [provided by RefSeq, Jul 2010]

GeneCards Summary for EGFR Gene

EGFR (Epidermal Growth Factor Receptor) is a Protein Coding gene. Diseases associated with EGFR include brain ependymoma and esophageal basaloid squamous cell carcinoma. Among its related pathways are PI3K-Akt signaling pathway and PI-3K cascade. GO annotations related to this gene include identical protein binding and chromatin binding. An important paralog of this gene is TNK1.

UniProtKB/Swiss-Prot for EGFR Gene

  • Receptor tyrosine kinase binding ligands of the EGF family and activating several signaling cascades to convert extracellular cues into appropriate cellular responses. Known ligands include EGF, TGFA/TGF-alpha, amphiregulin, epigen/EPGN, BTC/betacellulin, epiregulin/EREG and HBEGF/heparin-binding EGF. Ligand binding triggers receptor homo- and/or heterodimerization and autophosphorylation on key cytoplasmic residues. The phosphorylated receptor recruits adapter proteins like GRB2 which in turn activates complex downstream signaling cascades. Activates at least 4 major downstream signaling cascades including the RAS-RAF-MEK-ERK, PI3 kinase-AKT, PLCgamma-PKC and STATs modules. May also activate the NF-kappa-B signaling cascade. Also directly phosphorylates other proteins like RGS16, activating its GTPase activity and probably coupling the EGF receptor signaling to the G protein-coupled receptor signaling. Also phosphorylates MUC1 and increases its interaction with SRC and CTNNB1/beta-catenin

  • Isoform 2 may act as an antagonist of EGF action

Tocris Summary for EGFR Gene

  • The epidermal growth factor receptor (EGFR) is a receptor tyrosine kinase of the ErbB family. Four members of the ErbB family have been identified; EGFR (ErbB1, HER1), ErbB2 (HER2), ErbB3 (HER3) and ErbB4 (HER4). EGFR signaling is initiated by ligand binding to the extracellular ligand binding domain. This initiates receptor homo-/hetero-dimerization and autophosphorylation by the intracellular kinase domain, resulting in receptor activation. Following activation, phosphorylation of cytoplasmic substrates occurs and a signaling cascade is initiated that drives many cellular responses, including changes in gene expression, cytoskeletal rearrangement, anti-apoptosis and increased cell proliferation.

Gene Wiki entry for EGFR Gene

PharmGKB "VIP" Summary for EGFR Gene

No data available for fRNAdb sequence ontologies and piRNA Summary for EGFR Gene

Genomics for EGFR Gene

Genomic Location for EGFR Gene

Start:
55,019,021 bp from pter
End:
55,256,620 bp from pter
Size:
237,600 bases
Orientation:
Plus strand

Genomic View for EGFR Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for EGFR Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for EGFR Gene

Regulatory Elements for EGFR Gene

Proteins for EGFR Gene

  • Protein details for EGFR Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P00533-EGFR_HUMAN
    Recommended name:
    Epidermal growth factor receptor
    Protein Accession:
    P00533
    Secondary Accessions:
    • O00688
    • O00732
    • P06268
    • Q14225
    • Q68GS5
    • Q92795
    • Q9BZS2
    • Q9GZX1
    • Q9H2C9
    • Q9H3C9
    • Q9UMD7
    • Q9UMD8
    • Q9UMG5

    Protein attributes for EGFR Gene

    Size:
    1210 amino acids
    Molecular mass:
    134277 Da
    Quaternary structure:
    • Binding of the ligand triggers homo- and/or heterodimerization of the receptor triggering its autophosphorylation. Heterodimer with ERBB2. Interacts with ERRFI1; inhibits dimerization of the kinase domain and autophosphorylation. Part of a complex with ERBB2 and either PIK3C2A or PIK3C2B. Interacts with GRB2; an adapter protein coupling the receptor to downstream signaling pathways. Interacts with GAB2; involved in signaling downstream of EGFR. Interacts with STAT3; mediates EGFR downstream signaling in cell proliferation. Interacts with RIPK1; involved in NF-kappa-B activation. Interacts (autophosphorylated) with CBL, CBLB and CBLC; involved in EGFR ubiquitination and regulation. Interacts with SOCS5; regulates EGFR degradation through TCEB1- and TCEB2-mediated ubiquitination and proteasomal degradation. Interacts with PRMT5; methylates EGFR and enhances interaction with PTPN6. Interacts (phosphorylated) with PTPN6; inhibits EGFR-dependent activation of MAPK/ERK. Interacts with COPG1; essential for regulation of EGF-dependent nuclear transport of EGFR by retrograde trafficking from the Golgi to the ER. Interacts with TNK2; this interaction is dependent on EGF stimulation and kinase activity of EGFR. Interacts with PCNA; positively regulates PCNA. Interacts with PELP1. Interacts with MUC1. Interacts with AP2M1. Interacts with FER. May interact with EPS8; mediates EPS8 phosphorylation. Interacts (via SH2 domains) with GRB2, NCK1 and NCK2. Interacts with ATX2. Interacts with GAREM. Interacts (ubiquitinated) with ANKRD13A/B/D; the interaction is direct and may regulate EGFR internalization after EGF stimulation. Interacts with GPER1; the interaction occurs in an estrogen-dependent manner. Interacts (via C-terminal cytoplasmic kinase domain) with ZPR1 (via zinc fingers). Interacts with RNF115 and RNF126.

    Three dimensional structures from OCA and Proteopedia for EGFR Gene

    Alternative splice isoforms for EGFR Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for EGFR Gene

Proteomics data for EGFR Gene at MOPED

Post-translational modifications for EGFR Gene

  • Methylated. Methylation at Arg-1199 by PRMT5 stimulates phosphorylation at Tyr-1197.
  • Monoubiquitinated and polyubiquitinated upon EGF stimulation; which does not affect tyrosine kinase activity or signaling capacity but may play a role in lysosomal targeting. Polyubiquitin linkage is mainly through Lys-63, but linkage through Lys-48, Lys-11 and Lys-29 also occurs. Deubiquitination by OTUD7B prevents degradation. Ubiquitinated by RNF115 and RNF126 (By similarity).
  • Phosphorylation at Ser-695 is partial and occurs only if Thr-693 is phosphorylated. Phosphorylation at Thr-678 and Thr-693 by PRKD1 inhibits EGF-induced MAPK8/JNK1 activation. Dephosphorylation by PTPRJ prevents endocytosis and stabilizes the receptor at the plasma membrane. Autophosphorylation at Tyr-1197 is stimulated by methylation at Arg-1199 and enhances interaction with PTPN6. Autophosphorylation at Tyr-1092 and/or Tyr-1110 recruits STAT3. Dephosphorylated by PTPN1 and PTPN2.
  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys716, Lys737, Lys754, Lys860, Lys867, Lys929, and Lys970
  • Glycosylation at Asn56, Asn73, Asn128, Asn175, Asn196, Asn352, Asn361, Asn413, Asn444, Asn528, Asn568, Asn603, and Asn623

Other Protein References for EGFR Gene

Domains for EGFR Gene

UniProtKB/Swiss-Prot:

EGFR_HUMAN
Domain:
  • Contains 1 protein kinase domain.:
    • P00533
Family:
  • Belongs to the protein kinase superfamily. Tyr protein kinase family. EGF receptor subfamily.:
    • P00533
genes like me logo Genes that share domains with EGFR: view

Function for EGFR Gene

Molecular function for EGFR Gene

GENATLAS Biochemistry: epidermal growth factor receptor,also binding transforming growth factor alpha (TGFA),involved in early craniofacial development and palate closure,phosphorylating GJB1,amplified in prostate carcinoma and in astrocytomas,deleted in glioblastomas and mutated in malignant oral keratinocytes
UniProtKB/Swiss-Prot CatalyticActivity: ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.
UniProtKB/Swiss-Prot EnzymeRegulation: Endocytosis and inhibition of the activated EGFR by phosphatases like PTPRJ and PTPRK constitute immediate regulatory mechanisms. Upon EGF-binding phosphorylates EPS15 that regulates EGFR endocytosis and activity. Moreover, inducible feedback inhibitors including LRIG1, SOCS4, SOCS5 and ERRFI1 constitute alternative regulatory mechanisms for the EGFR signaling.
UniProtKB/Swiss-Prot Function: Receptor tyrosine kinase binding ligands of the EGF family and activating several signaling cascades to convert extracellular cues into appropriate cellular responses. Known ligands include EGF, TGFA/TGF-alpha, amphiregulin, epigen/EPGN, BTC/betacellulin, epiregulin/EREG and HBEGF/heparin-binding EGF. Ligand binding triggers receptor homo- and/or heterodimerization and autophosphorylation on key cytoplasmic residues. The phosphorylated receptor recruits adapter proteins like GRB2 which in turn activates complex downstream signaling cascades. Activates at least 4 major downstream signaling cascades including the RAS-RAF-MEK-ERK, PI3 kinase-AKT, PLCgamma-PKC and STATs modules. May also activate the NF-kappa-B signaling cascade. Also directly phosphorylates other proteins like RGS16, activating its GTPase activity and probably coupling the EGF receptor signaling to the G protein-coupled receptor signaling. Also phosphorylates MUC1 and increases its interaction with SRC and CTNNB1/beta-catenin
UniProtKB/Swiss-Prot Function: Isoform 2 may act as an antagonist of EGF action

Enzyme Numbers (IUBMB) for EGFR Gene

Gene Ontology (GO) - Molecular Function for EGFR Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001948 glycoprotein binding IEA --
GO:0003682 chromatin binding IDA 20551055
GO:0003690 double-stranded DNA binding NAS 6325948
GO:0004672 protein kinase activity --
GO:0004709 MAP kinase kinase kinase activity NAS 15542601
genes like me logo Genes that share ontologies with EGFR: view
genes like me logo Genes that share phenotypes with EGFR: view

Animal Models for EGFR Gene

MGI Knock Outs for EGFR:

No data available for Transcription Factor Targeting and HOMER Transcription for EGFR Gene

Localization for EGFR Gene

Subcellular locations from UniProtKB/Swiss-Prot for EGFR Gene

Cell membrane; Single-pass type I membrane protein. Endoplasmic reticulum membrane; Single-pass type I membrane protein. Golgi apparatus membrane; Single-pass type I membrane protein. Nucleus membrane; Single-pass type I membrane protein. Endosome. Endosome membrane. Nucleus. Note=In response to EGF, translocated from the cell membrane to the nucleus via Golgi and ER. Endocytosed upon activation by ligand. Colocalized with GPER1 in the nucleus of estrogen agonist-induced cancer-associated fibroblasts (CAF).
Isoform 2: Secreted.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for EGFR Gene COMPARTMENTS Subcellular localization image for EGFR gene
Compartment Confidence
endoplasmic reticulum 5
endosome 5
extracellular 5
golgi apparatus 5
nucleus 5
plasma membrane 5
cytosol 4
cytoskeleton 3
lysosome 2
mitochondrion 2
vacuole 2
peroxisome 1

Gene Ontology (GO) - Cellular Components for EGFR Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000139 Golgi membrane IEA --
GO:0005615 extracellular space NAS 9103388
GO:0005622 intracellular --
GO:0005634 nucleus IDA 12828935
GO:0005737 cytoplasm IDA --
genes like me logo Genes that share ontologies with EGFR: view

Pathways for EGFR Gene

SuperPathways for EGFR Gene

Superpath Contained pathways
1 Signaling by FGFR
2 Apoptotic Pathways in Synovial Fibroblasts
3 PI-3K cascade
4 GPCR Pathway
5 Glioma
.51
.43
genes like me logo Genes that share pathways with EGFR: view

Interacting Proteins for EGFR Gene

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000275493%0d%0a9606.ENSP00000350941%0d%0a9606.ENSP00000269571%0d%0a9606.ENSP00000265171%0d%0a9606.ENSP00000344818%0d%0a9606.ENSP00000264657%0d%0a
Selected Interacting proteins: P00533-EGFR_HUMAN ENSP00000275493 for EGFR Gene via MINT STRING UniProtKB I2D

Symbol External ID(s) Details
GRB2
SHC1
CBL
EGF
ABL2

Gene Ontology (GO) - Biological Process for EGFR Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000165 MAPK cascade NAS 15542601
GO:0000186 activation of MAPKK activity IEA --
GO:0000902 cell morphogenesis --
GO:0001503 ossification NAS 12925580
GO:0001889 liver development IEA --
genes like me logo Genes that share ontologies with EGFR: view

Compounds for EGFR Gene

(31) ApexBio Compounds for EGFR Gene

Compound Action Cas Number
AC480 (BMS-599626) orally bioavailable inhibitor of the HER1, HER2 and HER4 [714971-09-2]
AEE788 (NVP-AEE788) novel multitargeted HER 1/2 and VEGFR 1/2 [497839-62-0]
Afatinib (BIBW2992) Irreversible EGFR and HER2 inhibitor [439081-18-2]
AG-18 Inhibits EGFR,PDGFR [118409-57-7]
AG-490 inhibitor of EGFR [133550-30-8]
AP26113 Dual inhibitor of anaplastic lymphoma kinase (ALK) and epidermal growth factor receptor (EGFR). [1197958-12-5]
ARRY-380 orally bioavailable inhibitor of the human EGFR tyrosine kinase ErbB-2. [937265-83-3]
AZD8931 (Sapitinib) ATP competitive and reversible inhibitor of EGFR (ErbB-1), Neu (ErbB-2) and ErbB-3. [848942-61-0]
BMS-690514 potent and selective inhibitor of epidermal growth factor receptor (EGFR), HER2, and HER4 [859853-30-8]
Butein a reversible, ATP-competitive, selective, and highly potent inhibitor of PI 3-kinase beta [487-52-5]
Canertinib (CI-1033) Potent and selective inhibitor of tyrosine residue phosphorylation of EGFR [267243-28-7]
CO-1686 novel, irreversible and orally delivered kinase inhibitor [1374640-70-6]
Compound 56 Cell-permeable, reversible, and ATP-competitive inhibitor of tyrosine kinase activity of EGFR [171745-13-4]
CP-724714 marked selectively against EGFR [537705-08-1]
CUDC-101 Multitargeted HDAC inhibitor [1012054-59-9]
Dacomitinib (PF299804, PF299) Highly selective and irreversible pan-EGFR family inhibitor [1110813-31-4]
Erlotinib potent and orally-bioavailable inhibitor of EGFR tyrosine kinase. [183321-74-6]
Gefitinib (ZD1839) Selective EGFR inhibitor [184475-35-2]
Gefitinib hydrochloride EGFR inhibitor [184475-55-6]
Icotinib Hydrochloride orally available quinazoline-based inhibitor of EGFR [1204313-51-8]
Lapatinib Dual inhibitor of EGFR and HER2 [231277-92-2]
Lapatinib Ditosylate Dual inhibitor of EGFR and HER2 [388082-78-8]
Neratinib (HKI-272) Potent HER2 and EGFR inhibitor [698387-09-6]
PD153035 HCl potent and specific inhibitor of EGFR [183322-45-4]
PD153035 hydrochloride Selective and extremely potent EGFR inhibitor, inhibits its tyrosine kinase activity, ATP competitive, reversible [153436-54-5]
PD168393 potent, irreversible, cell-permeable and selective inhibitor of EGFR [194423-15-9]
Pelitinib (EKB-569) Covalently binds to EGFR, inhibiting receptor phosphorylation and thus inhibiting signal transduction from EGFR. [257933-82-7]
Varlitinib (ARRY334543) orally bioavailable inhibitor of the EGFR family [845272-21-1]
WZ3146 Potent and mutant-selective EGFR phosphorylation inhibitor [1214265-56-1]
WZ4002 Mutant-selective EGFR inhibitor(L858R,T790M) [1213269-23-8]
WZ8040 Irreversible inhibitor of mutated EGFR T790M [1214265-57-2]

(5) Tocris Compounds for EGFR Gene

Compound Action Cas Number
AG 1478 hydrochloride Highly potent EGFR-kinase inhibitor [153436-53-4]
AG 490 EGFR-kinase inhibitor. Also JAK2, JAK3 inhibitor [133550-30-8]
Genistein EGFR kinase inhibitor. Also estrogen and PPARgamma ligand [446-72-0]
Iressa Orally active, selective EGFR inhibitor [184475-35-2]
JNJ 28871063 hydrochloride Potent ErbB receptor family inhibitor [944341-54-2]

(4) HMDB Compounds for EGFR Gene

Compound Synonyms Cas Number PubMed IDs
Adenosine triphosphate
  • 5'-(tetrahydrogen triphosphate) Adenosine
56-65-5
ADP
  • adenosindiphosphorsaeure
58-64-0
Aldosterone
  • (+)-Aldosterone
52-39-1
L-Tyrosine
  • (-)-a-Amino-p-hydroxyhydrocinnamate
60-18-4

(12) Drugbank Compounds for EGFR Gene

Compound Synonyms Cas Number Type Actions PubMed IDs
Afatinib
850140-72-6 target inhibitor
Cetuximab
  • Anti EGFR
205923-56-4 target antagonist
Erlotinib
  • CP358774
183321-74-6 target antagonist
Flavopiridol
  • Alvocidib
131740-09-5 target
Gefitinib
184475-35-2 target antagonist

(7) IUPHAR Ligand for EGFR Gene

Ligand Type Action Affinity Pubmed IDs
EGF None None
betacellulin None None
epiregulin None None
HB-EGF None None
amphiregulin None None
TGFalpha None None
epigen None None

(119) Novoseek inferred chemical compound relationships for EGFR Gene

Compound -log(P) Hits PubMed IDs
gefitinib 97.2 464
erlotinib 96.4 268
cetuximab 95.9 288
tyrosine 93.9 349
ag 1478 93.3 151

(14) PharmGKB related drug/compound annotations for EGFR Gene

genes like me logo Genes that share compounds with EGFR: view

Transcripts for EGFR Gene

Unigene Clusters for EGFR Gene

Epidermal growth factor receptor:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for EGFR Gene

No ASD Table

Relevant External Links for EGFR Gene

GeneLoc Exon Structure for
EGFR
ECgene alternative splicing isoforms for
EGFR

Expression for EGFR Gene

mRNA expression in normal human tissues for EGFR Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for EGFR Gene

SOURCE GeneReport for Unigene cluster for EGFR Gene Hs.488293

mRNA Expression by UniProt/SwissProt for EGFR Gene

P00533-EGFR_HUMAN
Tissue specificity: Ubiquitously expressed. Isoform 2 is also expressed in ovarian cancers.
genes like me logo Genes that share expressions with EGFR: view

Orthologs for EGFR Gene

This gene was present in the common ancestor of animals.

Orthologs for EGFR Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia EGFR 36
  • 99.26 (n)
  • 99.67 (a)
EGFR 37
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia EGFR 36
  • 85.62 (n)
  • 87.83 (a)
EGFR 37
  • 88 (a)
OneToOne
dog
(Canis familiaris)
Mammalia EGFR 36
  • 87.29 (n)
  • 91.68 (a)
EGFR 37
  • 92 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Egfr 36
  • 85.13 (n)
  • 90.65 (a)
Egfr 16
Egfr 37
  • 90 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia EGFR 37
  • 83 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia EGFR 37
  • 83 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Egfr 36
  • 84.88 (n)
  • 90.56 (a)
chicken
(Gallus gallus)
Aves EGFR 36
  • 73.92 (n)
  • 78.48 (a)
EGFR 37
  • 75 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia EGFR 37
  • 73 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia egfr 36
  • 65.85 (n)
  • 68.05 (a)
zebrafish
(Danio rerio)
Actinopterygii egfr 36
EGFR (2 of 5) 37
  • 50 (a)
OneToMany
EGFR (3 of 5) 37
  • 89 (a)
OneToMany
EGFR (4 of 5) 37
  • 53 (a)
OneToMany
EGFR (5 of 5) 37
  • 39 (a)
OneToMany
egfra 36
  • 64.59 (n)
  • 64.85 (a)
egfra 37
  • 61 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta Egfr 38
  • 40 (a)
worm
(Caenorhabditis elegans)
Secernentea let-23 38
  • 29 (a)
Species with no ortholog for EGFR:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for EGFR Gene

ENSEMBL:
Gene Tree for EGFR (if available)
TreeFam:
Gene Tree for EGFR (if available)

Paralogs for EGFR Gene

Paralogs for EGFR Gene

genes like me logo Genes that share paralogs with EGFR: view

Variants for EGFR Gene

Sequence variations from dbSNP and Humsavar for EGFR Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type MAF
rs712829 -- 55,019,062(+) CCTCC(G/T)CCCCC utr-variant-5-prime
rs712830 -- 55,019,087(+) GCCCG(A/C)CGCGG utr-variant-5-prime
rs712831 -- 55,175,089(+) CATGA(C/T)GAGTG intron-variant
rs718836 -- 55,174,611(+) CCCAG(A/T)GTCCC intron-variant
rs723526 -- 55,067,126(+) GGCGC(A/G)GTTTC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for EGFR Gene

Variant ID Type Subtype PubMed ID
esv2734425 CNV Deletion 23290073
nsv888055 CNV Loss 21882294
nsv5752 CNV Loss 18451855
nsv528853 CNV Loss 19592680
nsv5753 CNV Insertion 18451855
esv22171 CNV Loss 19812545
esv2660266 CNV Deletion 23128226
nsv888057 CNV Loss 21882294
nsv515544 CNV Loss 19592680
nsv888058 CNV Loss 21882294
nsv888059 CNV Loss 21882294
esv26220 CNV Loss 19812545
dgv1133e201 CNV Deletion 23290073
esv5645 CNV Loss 19470904
esv2734437 CNV Deletion 23290073
esv2734440 CNV Deletion 23290073
nsv366872 CNV Loss 16902084
esv2734441 CNV Deletion 23290073
esv2590945 CNV Insertion 19546169

Relevant External Links for EGFR Gene

HapMap Linkage Disequilibrium report
EGFR
Human Gene Mutation Database (HGMD)
EGFR

Disorders for EGFR Gene

(1) OMIM Diseases for EGFR Gene (131550)

UniProtKB/Swiss-Prot

EGFR_HUMAN
  • Lung cancer (LNCR) [MIM:211980]: A common malignancy affecting tissues of the lung. The most common form of lung cancer is non-small cell lung cancer (NSCLC) that can be divided into 3 major histologic subtypes: squamous cell carcinoma, adenocarcinoma, and large cell lung cancer. NSCLC is often diagnosed at an advanced stage and has a poor prognosis. {ECO:0000269 PubMed:15118125, ECO:0000269 PubMed:16533793, ECO:0000269 PubMed:16672372}. Note=The gene represented in this entry is involved in disease pathogenesis.
  • Inflammatory skin and bowel disease, neonatal, 2 (NISBD2) [MIM:616069]: A disorder characterized by inflammatory features with neonatal onset, involving the skin, hair, and gut. The skin lesions involve perioral and perianal erythema, psoriasiform erythroderma, with flares of erythema, scaling, and widespread pustules. Gastrointestinal symptoms include malabsorptive diarrhea that is exacerbated by intercurrent gastrointestinal infections. The hair is short or broken, and the eyelashes and eyebrows are wiry and disorganized. {ECO:0000269 PubMed:24691054}. Note=The disease is caused by mutations affecting the gene represented in this entry.

(97) Novoseek inferred disease relationships for EGFR Gene

Disease -log(P) Hits PubMed IDs
nsclc 91.1 438
tumors 87.7 479
glioblastoma 85 285
cancer 84.6 298
cancer lung 84.4 310

Genatlas disease for EGFR Gene

glioblastoma,multiform (amplification of deleted/rearranged EGFR)

Relevant External Links for EGFR

Genetic Association Database (GAD)
EGFR
Human Genome Epidemiology (HuGE) Navigator
EGFR
Tumor Gene Database (TGDB):
EGFR
genes like me logo Genes that share disorders with EGFR: view

Publications for EGFR Gene

  1. Expression of a truncated epidermal growth factor receptor-like protein (TEGFR) in ovarian cancer. (PMID: 9103388) Ilekis J.V. … Scoccia B. (Gynecol. Oncol. 1997) 3 4 23
  2. PTEN mutation, EGFR amplification, and outcome in patients with anaplastic astrocytoma and glioblastoma multiforme. (PMID: 11504770) Smith J.S. … Jenkins R.B. (J. Natl. Cancer Inst. 2001) 3 23 49
  3. High frequency of epidermal growth factor receptor mutations with complex patterns in non-small cell lung cancers related to gefitinib responsiveness in Taiwan. (PMID: 15623594) Huang S.F. … Tsai S.F. (Clin. Cancer Res. 2004) 3 4 23
  4. Predictive and prognostic impact of epidermal growth factor receptor mutation in non-small-cell lung cancer patients treated with gefitinib. (PMID: 15710947) Han S.W. … Kim N.K. (J. Clin. Oncol. 2005) 3 23 49
  5. Mutations of the epidermal growth factor receptor gene predict prolonged survival after gefitinib treatment in patients with non-small-cell lung cancer with postoperative recurrence. (PMID: 15738541) Mitsudomi T. … Yatabe Y. (J. Clin. Oncol. 2005) 3 23 49

Products for EGFR Gene

  • Addgene plasmids for EGFR

Sources for EGFR Gene

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