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EGFR Gene

protein-coding GIFtS: 78

GC07P055054

epidermal growth factor receptor (erythroblastic leukemia viral (v-erb-b) oncogene homolog, avian)
(Previous name: epidermal growth factor receptor (avian erythroblastic leukemia viral (v-erb-b) oncogene homolog) )
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
(Previous symbol: ERBB)

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
About This Section

Aliases
EC 2.7.10.1 ^³
ERBB ^²
ERBB1 ^¹, ², ³
HER1 ^²
PIG61 ^²
mENA ^²

Descriptions
Receptor tyrosine-protein kinase ErbB-1 ^³
avian erythroblastic leukemia viral (v-erb-b) oncogene homolog ^²
cell growth inhibiting protein 40 ^²
cell proliferation-inducing protein 61 ^²
epidermal growth factor receptor ^²
epidermal growth factor receptor (avian erythroblastic leukemia viral (v-erb-b) oncogene homolog) ^¹
epidermal growth factor receptor (erythroblastic leukemia viral (v-erb-b) oncogene homolog, avian) ^²

External Ids
HGNC: 3236¹
Entrez Gene: 1956²
UniProtKB: P00533³
Ensembl: ENSG00000146648⁷

Search outside databases for aliases for EGFR gene

Previous GC identifers: GC07P054550 GC07P054794 GC07P054828 GC07P054860

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

EntrezGene summary for EGFR:

The protein encoded by this gene is a transmembrane glycoprotein that is a member of the protein

kinase superfamily. This protein is a receptor for members of the epidermal growth factor family.

EGFR is a cell surface protein that binds to epidermal growth factor. Binding of the protein to a

ligand induces receptor dimerization and tyrosine autophosphorylation and leads to cell

proliferation. Mutations in this gene are associated with lung cancer. [provided by RefSeq]

UniProtKB/Swiss-Prot: EGFR_HUMAN, P00533

Function: Isoform 2/truncated isoform may act as an antagonist

Gene Wiki entry for EGFR (Epidermal_growth_factor_receptor)

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:

UCSC Golden Path with GeneCards custom track

Transcription factor binding sites upstream to the EGFR gene

Entrez Gene cytogenetic band: 7p12 Ensembl cytogenetic band: 7p11.2 HGNC cytogenetic band: 7p12

EGFR Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 7 GeneLoc Exon Structure

GeneLoc location for GC07P055054: (about GC identifiers)

Start:	55,054,219 bp from pter
End:	55,242,525 bp from pter
Size:	188,307 bases
Orientation:	plus strand

1 alternative location:

Chr7+,CRA_TCAG 55,092,507-55,280,831

RefSeq DNA sequence:

NC_000007.12 NT_033968.5 NT_079592.2

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
About This Section

UniProtKB/Swiss-Prot: EGFR_HUMAN, P00533 (See protein sequence)

Recommended Name: Epidermal growth factor receptor precursor

Size: 1210 amino acids; 134277 Da

Subunit: Binds RIPK1. CBL interacts with the autophosphorylated C-terminal tail of the EGF

receptor. Part of a complex with ERBB2 and either PIK3C2A or PIK3C2B. The autophosphorylated form

interacts with PIK3C2B, maybe indirectly. Interacts with PELP1. Binds MUC1

Subcellular location: Cell membrane; Single-pass type I membrane protein

Subcellular location: Isoform 2: Secreted

Miscellaneous: Binding of EGF to the receptor leads to dimerization, internalization of the

EGF-receptor complex, induction of the tyrosine kinase activity, stimulation of cell DNA

synthesis, and cell proliferation

PDB structures from and Proteopedia :

1DNQ (3D)

1DNR (3D)

1IVO (3D)

1M14 (3D)

1M17 (3D)

1MOX (3D)

1NQL (3D)

1XKK (3D)

1YY9 (3D)

1Z9I (3D)

2EB2 (3D)

2EB3 (3D)

2EXP (3D)

2EXQ (3D)

2GS2 (3D)

2GS6 (3D)

2GS7 (3D)

2ITN (3D)

2ITO (3D)

2ITP (3D)

2ITQ (3D)

2ITT (3D)

2ITU (3D)

2ITV (3D)

2ITW (3D)

2ITX (3D)

2ITY (3D)

2ITZ (3D)

2J5E (3D)

2J5F (3D)

2J6M (3D)

2JIT (3D)

2JIU (3D)

2JIV (3D)

2RF9 (3D)

2RFD (3D)

2RFE (3D)

2RGP (3D)

3B2U (3D)

3B2V (3D)

3BEL (3D)

3BUO (3D)

3C09 (3D)

Secondary accessions: O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7

Q9UMD8 Q9UMG5

Alternative splicing: 4 isoforms: P00533-1 P00533-2 P00533-3 P00533-4

Post-translational modifications:

Phosphorylation of Ser-695 is partial and occurs only if Thr-693 is phosphorylated¹

Monoubiquitinated and polyubiquitinated upon EGF stimulation; which does not affect tyrosine kinase

activity or signaling capacity but may play a role in lysosomal targeting. Polyubiquitin linkage

is mainly through 'Lys-63', but linkage through 'Lys-48', 'Lys-11' and 'Lys-29' also occur¹

View phosphorylation sites using PhosphoSite²

REFSEQ proteins (4 alternative transcripts):

NP_005219.2 NP_958439.1 NP_958440.1 NP_958441.1

ENSEMBL proteins:

ENSP00000378880 ENSP00000342376 ENSP00000345973 ENSP00000275493

Human Recombinant Proteins

	Invitrogen human recombinant proteins for EGFR
	Millipore Purified and/or Recombinant EGFR Protein
	Sigma-Aldrich Proteins and AQUA Peptides for EGFR
	R&D Systems Recombinant & Natural Proteins for EGFR (EGF R/ErbB1)
	Enzo Life Sciences proteins for EGFR
	Recombinant Proteins from Abcam (EGFR VIII, MAP Kinase Substrate, EGFR)
	Human Recombinant Proteins from Abnova (EGFR)

Browse Origene for full length recombinant human proteins expressed in human HEK293 cells

5/12 Gene Ontology (GO) cellular component terms (links to tree view) (see all 12 ):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005576	extracellular region	IEA	--
GO:0005615	extracellular space	NAS	9103388
GO:0005622	intracellular	IEA	--
GO:0005634	nucleus	IDA	12828935
GO:0005737	cytoplasm	IDA	12435727

About this table

Antibodies for EGFR:

	Invitrogen Antibodies for EGFR
	Millipore Mono- and Polyclonal Antibodies for the study of EGFR
	Sigma-Aldrich Antibody Arrays and Antibodies for EGFR
	R&D Systems Antibodies for EGFR (EGF R/ErbB1)
	Cell Signaling Technology (CST) Antibodies for EGFR
	Antibodies from Abcam (EGFR VIII, MAP Kinase Substrate, EGFR), each with their Abpromise^SM
	Monoclonal and Polyclonal Antibodies from Abnova (EGFR)
	Novus Biologicals Antibodies for EGFR

Assays for EGFR:

	Invitrogen Assays for EGFR
	Millipore Kits and Assays for the Analysis of EGFR
	R&D Systems ELISAs for EGFR (EGF R/ErbB1) (see all)
	Cell Signaling Technology (CST) Sandwich ELISA Kits for EGFR
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

Graphical View of Domain Structure for InterPro Entry P00533

ProtoNet protein and cluster: P00533

4 Blocks protein families:

IPB000494 Epidermal growth-factor receptor (EGFR)

IPB006211 Furin-like cysteine rich region

IPB006212 Furin-like repeat

IPB008266 Tyrosine protein kinase

UniProtKB/Swiss-Prot: EGFR_HUMAN, P00533

Similarity: Belongs to the protein kinase superfamily. Tyr protein kinase family. EGF receptor

subfamily

Similarity: Contains 1 protein kinase domain

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (EGFR)
		Millipore RNAi Products for the Analysis of EGFR Gene knock-down
		Abnova Chimera RNAi Products for Gene knock-down (EGFR)

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 4): NM_005228

Applied Biosystems Silencer® siRNAs for EGFR

Sigma-Aldrich siRNA and siRNA Panels for EGFR

Sigma-Aldrich shRNA Panels and shRNA for EGFR

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Invitrogen Clones for EGFR
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clones in CMV expression vector (see all 4): NM_005228
Myc/DDK tagged cDNA clones in CMV expression vector (see all 4): NM_005228
untagged cDNA clones in CMV expression vector (see all 4): NM_005228

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_005228

UniProtKB/Swiss-Prot: EGFR_HUMAN, P00533

Function: Receptor for EGF, but also for other members of the EGF family, as TGF-alpha,

amphiregulin, betacellulin, heparin-binding EGF-like growth factor, GP30 and vaccinia virus growth

factor. Is involved in the control of cell growth and differentiation. Phosphorylates MUC1 in

breast cancer cells and increases the interaction of MUC1 with C-SRC and CTNNB1/beta-catenin

Function: Isoform 2/truncated isoform may act as an antagonist

Catalytic activity: ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate

Enzyme Number (IUBMB): EC 2.7.10.1

Genatlas biochemistry entry for EGFR:

epidermal growth factor receptor,also binding transforming growth factor alpha (TGFA),involved in

early craniofacial development and palate closure,phosphorylating GJB1,amplified in prostate

carcinoma and in astrocytomas,deleted in glioblastomas and mutated in malignant oral keratinocytes

15/29 MGI mutant phenotypes (inferred from 13 alleles) (MGI details for Egfr) (see all 29 ):

	adipose tissue	cellular	craniofacial	digestive/alimentary
embryogenesis	endocrine/exocrine gland	growth/size	hearing/vestibular/ear	homeostasis/metabolism
immune system	lethality-postnatal	lethality-prenatal/perinatal	life span-post-weaning/aging	limbs/digits/tail

5/12 Gene Ontology (GO) molecular function terms (links to tree view) (see all 12 ):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0000166	nucleotide binding	IEA	--
GO:0003690	double-stranded DNA binding	NAS	6325948
GO:0004710	MAP/ERK kinase kinase activity	NAS	15542601
GO:0004888	transmembrane receptor activity	IDA	7736574
GO:0005006	epidermal growth factor receptor activity	NAS	2790960 6325948

About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

5/15 Sigma-Aldrich "Your Favorite Gene" Pathways for EGFR (Your Favorite Gene powered by Ingenuity) (see all 15 )

PTEN Signaling
Thrombin Signaling
Caveolar-mediated Endocytosis
Glioma Signaling
Agrin Interactions at Neuromuscular Junction

GeneDecks EGFR for the pathways selected above

About GeneDecksing

Gene Network Central^TM Interacting Genes and Proteins Network for EGFR

5/457 Interacting proteins for EGFR (P00533^{1, 2} ENSP00000275493³) via UniProtKB, MINT, and/or STRING (see all 457 )

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
SHC1	P29353², ENSP00000357432³	MINT-74727 MINT-74729 MINT-74731 MINT-1782377 MINT-61491 MINT-1782352 MINT-74732 MINT-61499 MINT-61501 MINT-74730 MINT-17353 MINT-61495 MINT-61482 MINT-74728 MINT-61503 MINT-61489 STRING (score=.999)
PTPN1	P18031², ENSP00000360683³	MINT-6762409 MINT-6762370 MINT-6793358 MINT-6793373 STRING (score=.999)
PTPN11	Q06124², ENSP00000340944³	MINT-61484 MINT-61492 MINT-61488 MINT-74689 STRING (score=.999)
PIK3R1	P27986², ENSP00000274335³	MINT-16351 MINT-74598 MINT-74595 MINT-74606 STRING (score=.995)
SH3KBP1	Q96B97², ENSP00000369049³	MINT-6170185 MINT-6170268 MINT-6170377 STRING (score=.997)

About this table

5/19 Gene Ontology (GO) biological process terms (links to tree view) (see all 19 ):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0001503	ossification	NAS	12925580
GO:0006950	response to stress	NAS	12828935
GO:0007166	cell surface receptor linked signal transduction	IDA	7736574
GO:0007173	epidermal growth factor receptor signaling pathway	IDA	12435727
GO:0007202	activation of phospholipase C activity	TAS	12435727

About this table

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Enzo Life Sciences drugs & compounds for EGFR

Sigma-Aldrich Small Molecules for EGFR:

Antagonist Inhibitor

Compounds for EGFR available from Tocris Bioscience

Compound	Action	CAS number
Iressa	Orally active, selective EGFR inhibitor	[184475-35-2]
JNJ 28871063 hydrochloride	Potent ErbB receptor family inhibitor	[944341-54-2]
PD 153035 hydrochloride	EGFR-kinase inhibitor	[153436-54-5]
AG 1478 hydrochloride	Highly potent EGFR-kinase inhibitor	[153436-53-4]

About this table

10/21 Novoseek chemical compound relationships for EGFR gene (see all 21 )

Compound	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
tyrosine	93.65	4459	16263724 (9), 16287490 (8), 12589790 (7), 10068444 (6) (see all 99)
zd6474	84.42	141	15604279 (8), 12684431 (5), 17145834 (4), 16688779 (3) (see all 54)
pki-166	80.41	36	12429651 (3), 18519677 (2), 10850439 (2), 15201994 (2) (see all 19)
quinazoline	76.53	37	12546563 (3), 17449254 (2), 18702009 (2), 12188892 (1) (see all 28)
bibx-1382bs	74.84	5	15199094 (2), 18644194 (1), 14530164 (1), 15734199 (1)
phosphotyrosine	72.49	132	18037521 (5), 17714814 (5), 8931669 (3), 7679612 (3) (see all 70)
pd158780	72.25	12	10341215 (2), 9774435 (1), 15615697 (1), 12838503 (1) (see all 7)
pertuzumab	72.18	15	17627612 (2), 15503865 (1), 18053062 (1), 17635517 (1) (see all 10)
phosphatidylinositol	70.49	128	8125197 (2), 9417065 (2), 17121914 (2), 11098053 (2) (see all 97)
ci1033	64.12	6	14763145 (1), 15688609 (1), 11212277 (1), 17035230 (1)

About this table

6 PharmGKB drug compound relationships for EGFR gene

Drug compound	PharmGKB Relations	PubMed IDs for articles supporting these relationships
EKB-569	FA	14749472
GW2016	FA	12467226
antineoplastic agents	GN	12631599
canertinib	FA	15158449
erlotinib	CO GN	15329413
gefitinib	CO PD GN	15118073 15118125 15329413

About this table

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (EGFR)
		Millipore RNAi Products for the Analysis of EGFR Gene knock-down
		Abnova Chimera RNAi Products for Gene knock-down (EGFR)

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 4): NM_005228

Sigma-Aldrich siRNA and siRNA Panels for EGFR

Sigma-Aldrich shRNA Panels and shRNA for EGFR

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_005228 NM_201282 NM_201283 NM_201284

REFSEQ mRNAs for EGFR gene (4 alternative transcripts):

NM_005228.3 NM_201282.1 NM_201283.1 NM_201284.1

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_005228 NM_201282 NM_201283 NM_201284

               OriGene GFP tagged cDNA clones in CMV expression vector (see all 4): NM_005228
                                 Myc/DDK tagged cDNA clones in CMV expression vector (see all 4): NM_005228
                                 untagged cDNA clones in CMV expression vector (see all 4): NM_005228

Additional cDNA sequence:

AB209442.1 AF125253.1 AF277897.1 AK225422.1 AK290352.1 AK294750.1 AY550966.1 AY698023.1

AY698024.1 BC070081.1 BC094761.1 BC118665.1 BC128419.1 BC134346.1 CR603510.1 DQ088980.1

EF210210.1 EF210211.1 K03193.1 U48722.1 U95089.1 X00588.1 X00663.1

22 DOTS entries:

DT.97784849 DT.453606 DT.121058602 DT.86855651 DT.95165593 DT.101978019 DT.92446350 DT.100752430

DT.91654361 DT.121058582 DT.121058480 DT.121058532 DT.121058546 DT.121058650 DT.418647 DT.95254161

DT.97822681 DT.91710263 DT.91963338 DT.95095929 DT.95165591 DT.95229256

24/484 AceView cDNA sequences (see all 484 ):

AW262127 BM742695 R79549 AW276185 BM746312 CB268886 AA463742 CB269761

H80439 AL598260 AI493193 AF125253 AA873091 CR603510 CA446153 NM_201284

CA432352 AL040990 BM715282 AA904331 BE745530 T82902 AA702764 BF727163

highest scoring ESTs for EGFR:

X00588 AA019588 AA026089 AA100216 AA112918 AA228011 AA228049 AA234715 AA236408 AA236409

Unigene Cluster for EGFR:

Epidermal growth factor receptor (erythroblastic leukemia viral (v-erb-b) oncogene homolog, avian)

Hs.488293 [show with all ESTs]

Unigene Representative Sequence: NM_005228

GeneLoc Exon Structure

4 Ensembl transcripts including schematic representations:

ENST00000395504 ENST00000342916 ENST00000344576 ENST00000275493

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
About This Section

EGFR expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for EGFR

¹ / ² / ³

16 probe-sets matching EGFR gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
1537_at²^{, 3}	U95-A	1	1.00	1.00	0.36	0.51	X00588	1.00	1.00	1.00	1
37327_at²^{, 3}	U95-A	1	0.81	1.00	1.00	1.00	X00588	1.00	1.00	1.00	1
211550_at²^{, 3}	U133-A	1	1.00	1.00	--	--	AF125253	0.60	1.00	0.82	1
210984_x_at²^{, 3}	U133-A	1	1.00	1.00	--	--	U95089	0.60	1.00	0.82	1
211551_at²^{, 3}	U133-A	1	1.00	1.00	--	--	K03193	0.80	1.00	0.91	1
211607_x_at²^{, 3}	U133-A	1	1.00	1.00	--	--	U48722	0.60	1.00	0.82	1
201984_s_at²^{, 3}	U133-A	1	1.00	1.00	--	--	NM_005228	0.60	1.00	0.82	1
201983_s_at²^{, 3}	U133-A	1	1.00	1.00	--	--	AW157070	0.80	1.00	0.91	1
211607_x_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
201984_s_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
201983_s_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
1565483_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
1565484_x_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
210984_x_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
211550_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
211551_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--

About this table

Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: CCCGCATTAG

SOURCE GeneReport for Unigene cluster: Hs.488293
Expression variation in blood from EXPOLDB for EGFR
UniProtKB/Swiss-Prot: EGFR_HUMAN, P00533
Tissue specificity: Ubiquitously expressed. Isoform 2 is also expressed in ovarian cancers

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for EGFR gene from 5/8 species (see all 8 )

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	EGFR¹	--	epidermal growth factor receptor (erythroblastic leukemia more	86.77(n) 90.94(a)	404306 XM_533073.2 XP_533073.2
chimpanzee (Pan troglodytes)	EGFR¹	--	epidermal growth factor receptor (erythroblastic leukemia more	98.57(n) 98.68(a)	463415 XM_001156495.1 XP_001156495.1
cow (Bos taurus)	EGFR¹	--	epidermal growth factor receptor (erythroblastic leukemia more	85.69(n) 88.3(a)	407217 XM_592211.3 XP_592211.3
rat (Rattus norvegicus)	Egfr¹	--	epidermal growth factor receptor	84.91(n) 90.56(a)	24329 NM_031507.1 NP_113695.1
mouse (Mus musculus)	Egfr^{1, 5}	11 (9.00 cM)⁵	epidermal growth factor receptor^{1, 5}	85.13(n)¹ 90.65(a)¹	13649¹ NM_207655.2¹ NP_997538.1¹ AF124513⁵ AF125256⁵ (see all 38)

About this table Species with no ortholog for EGFR

ENSEMBL Gene Tree for EGFR

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

Paralogs for EGFR gene

ERBB3² ERBB2² ERBB4²

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

10/1454 NCBI SNPs in EGFR are shown (see all 1454 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 402)

AB	SNP ID	Valid	Chr 7 pos	Sequence	Recs	AA Chg	Type	More	Recs	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--			--
--	rs10277413^1,2	A,C,F,H	55205958(+)	`GGGACT/GCCATG`	2	--	ut3¹ int¹		11	NS EU EA WA	1160
	rs884904^1,2	A,C,F,H	55242976(+)	`CAGGGG/AGATTT`	1	--	ng3¹		15	EA NA MN EU WA NS	2842
	rs6593197^1,2	A,C,F,H	55053218(+)	`GAGGGG/ATCTGG`	4	--	ng5¹ tfbs³ trp³		6	EU EA WA	672
	rs10228436^1,2	A,C,F,H	55205762(+)	`CCCCCG/ACTTTT`	2	--	int¹ ut3¹		3	NS EU WA	370
	rs845550^1,2	C,F,H	55204268(+)	`GGAGGG/AACCCT`	3	--	int¹ ng3¹ trp³		4	EU EA WA	394
	rs6965469^1,2	C,F,H	55052461(+)	`ATATAC/TAAGCC`	4	--	ng5¹		11	EU EA WA NS	1248
	rs884225^1,2	A,C,F	55241578(-)	`GGGGCA/GGCATA`	1	--	ut3¹		21	NA EA NS MN	1706
	rs13222549^1,2	C,F,H	55192634(+)	`GAATCG/CCAGCG`	4	--	int¹ ng3¹		9	NS EU EA WA	1000
	rs759171^1,2	C,F,H	55053706(+)	`CCCCGC/AGAGGG`	4	--	ng5¹		13	NS EU EA WA	1528
--	rs10258568^1,2	A,C,F	55205721(+)	`CTCCTC/TCTGCC`	2	S/F	mis¹ int¹		6	NS	366

About this table

HapMap Linkage Disequilibrium images for EGFR (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
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OMIM: 131550 disorders: 211980 211980 211980

UniProtKB/Swiss-Prot: EGFR_HUMAN, P00533

Defects in EGFR are associated with lung cancer [MIM:211980]

10/97 Novoseek disease relationships for EGFR gene (see all 97 )

Disease	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
nsclc	89.90	2731	18710625 (7), 16106023 (6), 15777970 (6), 16140912 (6) (see all 99)
tumors	86.70	5808	14967457 (9), 11727256 (8), 1313356 (8), 18450321 (8) (see all 99)
glioblastoma	84.32	709	11511795 (7), 15618223 (6), 10728703 (6), 10029453 (5) (see all 99)
cancer	83.30	2328	11597399 (7), 1717146 (5), 16378905 (5), 17827454 (5) (see all 99)
carcinoma squamous cell	83.00	836	9828815 (5), 16550055 (5), 7970803 (5), 9816015 (5) (see all 99)
cancer lung	82.72	1227	12720099 (7), 19331130 (6), 16226114 (6), 17876048 (5) (see all 99)
breast cancer	81.88	1614	15095477 (8), 11859875 (8), 9066618 (6), 11455588 (6) (see all 99)
adenocarcinoma lung	81.60	361	16357156 (5), 18508816 (5), 7599067 (4), 19138956 (4) (see all 99)
glioblastoma multiforme	78.94	184	15746047 (4), 17236582 (4), 11504770 (4), 17679463 (3) (see all 98)
glioma	77.36	657	9216693 (8), 10595738 (8), 10430083 (7), 7714612 (6) (see all 99)

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2 PharmGKB disease relationships for EGFR gene

Disease	PharmGKB Relations	PubMed IDs for articles supporting these relationships
Lung Neoplasms	CO PD GN	15118073 15118125
Neoplasms	CO FA GN	14749472 15329413 12467226 15158449

About this table

Genatlas disease: EGFR

glioblastoma,multiform (amplification of deleted/rearranged EGFR)

Human Gene Mutation Database: EGFR
Genetic Association Database: EGFR
Human Genome Epidemiology Navigator: EGFR (278 documents)
Tumor Gene Database: EGFR
Breast Cancer Gene Database: EGFR

(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
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10/5423 PubMed articles for EGFR gene (see all 5423 ):

EGFR mutations in lung cancer: correlation with clinical response to gefitinib therapy. (PubMed id 15118125)^{1, 3, 4, 7} Paez J.G.... Meyerson M. (2004)
Activating mutations in the epidermal growth factor receptor underlying responsiveness of non-small-cell lung cancer to gefitinib. (PubMed id 15118073)^{1, 3, 7} Lynch T.J....Haber D.A. (2004)
EGF receptor gene mutations are common in lung cancers from "never smokers" and are associated with sensitivity of tumors to gefitinib and erlotinib. (PubMed id 15329413)^{1, 3, 7} Pao W....Varmus H. (2004)
Interethnic difference in the allelic distribution of human epidermal growth factor receptor intron 1 polymorphism. (PubMed id 12631599)^{3, 6, 7} Liu W....Ratain M.J. (2003)
EGFR and erbB2 mutation status in Japanese lung cancer patients. (PubMed id 16003726)^{1, 3, 6} Sasaki H....Fujii Y. (2006)
Mutations in the epidermal growth factor receptor gene are linked to smoking-independent, lung adenocarcinoma. (PubMed id 16052218)^{1, 3, 6} Sonobe M....Tanaka F. (2005)
Analysis of the dinucleotide repeat polymorphism in the epidermal growth factor receptor (EGFR) gene in head and neck cancer patients. (PubMed id 15829495)^{1, 3, 6} Etienne-Grimaldi M.C....Milano G. (2005)
Distinct epidermal growth factor receptor and KRAS mutation patterns in non-small cell lung cancer patients with different tobacco exposure and clinicopathologic features. (PubMed id 16533793)^{1, 3, 4} Tam I.Y.S.... Wong M.P. (2006)
Epidermal growth factor receptor mutations in needle biopsy/aspiration samples predict response to gefitinib therapy and survival of patients with advanced nonsmall cell lung cancer. (PubMed id 16152581)^{1, 3, 6} Shih J.Y....Yang P.C. (2006)
EGFR Mutation status in Japanese lung cancer patients: genotyping analysis using LightCycler. (PubMed id 15837743)^{1, 3, 6} Sasaki H....Fujii Y. (2005)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
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Entrez Gene: 1956	HGNC: 3236	AceView: EGFR	Ensembl:ENSG00000146648	euGenes: HUgn1956
ECgene: EGFR	H-InvDB: EGFR

(According to HUGE)
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(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
ATLAS Chromosomes in Cancer entry for EGFR	Genetics and Cytogenetics in Oncology and Haematology
GeneReviews	http://www.genetests.org/query?gene=EGFR
NIEHS-SNPs	http://egp.gs.washington.edu/data/egfr/
Wikipedia	http://en.wikipedia.org/wiki/Epidermal_growth_factor_receptor

Licensable Technologies for EGFR
(Available from WIS Yeda, Salk, Tufts)

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Licensable Technologies for EGFR gene:

Weizmann Institute:

Combination of Antibodies to EGFR

(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
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Products for EGFR:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for EGFR-related products

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

	Predesigned and custom siRNAs for EGFR		Antibodies for EGFR
	Explore super-pooled esiRNAs		Proteins for EGFR
	Lentivirus-delivered shRNAs for EGFR		Small molecules for EGFR
	"Your Favorite Gene" Pathways		feedback

	Antibodies		Primer Pairs
	Cell Culture Products		ELISAs
	Flow Cytometry Kits		Protease Activity Assays & Reagents
	Cell Selection/Detection Kits & Reagents		ELISA/Assay Development Kits & Reagents
	Multiplex/Array Assay Kits & Reagents		ELISpot Kits & Development Modules
	Recombinant & Natural Proteins

	Recombinant Proteins (EGFR)
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	Custom Service for Rabbit Pab from Full-length Protein

Antibodies & Assays for EGFR

	Recombinant Proteins (EGFR VIII, MAP Kinase Substrate, EGFR)
	Antibodies (EGFR VIII, MAP Kinase Substrate, EGFR)

Search OriGene for EGFR

Tocris compounds for EGFR

	Drugs/Proteins for EGFR
	Search www.enzolifesicences.com for proteins, assays, substrates, inhibitors & antibodies

Antibodies for EGFR

GeneCards Homepage - Last full update: 2 Jul 2009 Incremental update: 13 Oct 2009

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EGFR Gene at Home site.
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EGFR Gene

protein-coding GIFtS: 78

Aliases &
Descriptions
for EGFR

Summaries
for EGFR

Genomic Location
for EGFR

Proteins
for EGFR

Protein Domains/
Families
for EGFR

Gene Function
for EGFR

Pathways & Interactions
for EGFR

Drugs & Compounds
for EGFR

Transcripts
for EGFR

Expression
for EGFR

Orthologs
for EGFR

Paralogs
for EGFR

SNPs/Variants
for EGFR

Disorders & Mutations
for EGFR

Medical News
for EGFR

Publications
for EGFR

Search for EGFR

Genome Databases showing EGFR

Other Databases showing EGFR

Specialized Databases showing EGFR

Licensable Technologies
for EGFR

Services
for EGFR

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

EGFR Gene

protein-coding GIFtS: 78

Aliases & Descriptionsfor EGFR

Summariesfor EGFR

Genomic Locationfor EGFR

Proteinsfor EGFR

Protein Domains/Familiesfor EGFR

Gene Functionfor EGFR

Pathways & Interactionsfor EGFR

Drugs & Compoundsfor EGFR

Transcriptsfor EGFR

Expression for EGFR

Orthologsfor EGFR

Paralogsfor EGFR

SNPs/Variantsfor EGFR

Disorders & Mutationsfor EGFR

Medical Newsfor EGFR

Publicationsfor EGFR

Search for EGFR

Genome Databases showing EGFR

Other Databases showing EGFR

Specialized Databases showing EGFR

Licensable Technologiesfor EGFR

Servicesfor EGFR

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for EGFR

Summaries
for EGFR

Genomic Location
for EGFR

Proteins
for EGFR

Protein Domains/
Families
for EGFR

Gene Function
for EGFR

Pathways & Interactions
for EGFR

Drugs & Compounds
for EGFR

Transcripts
for EGFR

Expression
for EGFR

Orthologs
for EGFR

Paralogs
for EGFR

SNPs/Variants
for EGFR

Disorders & Mutations
for EGFR

Medical News
for EGFR

Publications
for EGFR

Licensable Technologies
for EGFR

Services
for EGFR