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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

EGFR Gene

protein-coding   GIFtS: 80
GCID: GC07P055054

Epidermal Growth Factor Receptor

(Previous name: epidermal growth factor receptor (avian erythroblastic leukemia...)
(Previous symbol: ERBB)
Microbiology & Infectious Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Epidermal Growth Factor Receptor1 2     Erythroblastic Leukemia Viral (V-Erb-B) Oncogene Homolog (Avian)1
ERBB1 2 3     PIG612
Proto-Oncogene C-ErbB-12 3     Avian Erythroblastic Leukemia Viral (V-Erb-B) Oncogene Homolog2
Receptor Tyrosine-Protein Kinase ErbB-12 3     Cell Growth Inhibiting Protein 402
ERBB12 3     Cell Proliferation-Inducing Protein 612
HER12 3     mENA2
EC 2.7.10.13 8     EC 2.7.108
Epidermal Growth Factor Receptor (Avian Erythroblastic Leukemia Viral
(V-Erb-B) Oncogene Homolog)1
     

External Ids:    HGNC: 32361   Entrez Gene: 19562   Ensembl: ENSG000001466487   OMIM: 1315505   UniProtKB: P005333   

Export aliases for EGFR gene to outside databases

Previous GC identifers: GC07P054550 GC07P054794 GC07P054828 GC07P054860


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for EGFR Gene:
The protein encoded by this gene is a transmembrane glycoprotein that is a member of the protein kinase
superfamily. This protein is a receptor for members of the epidermal growth factor family. EGFR is a cell surface
protein that binds to epidermal growth factor. Binding of the protein to a ligand induces receptor dimerization
and tyrosine autophosphorylation and leads to cell proliferation. Mutations in this gene are associated with lung
cancer. Multiple alternatively spliced transcript variants that encode different protein isoforms have been found
for this gene. (provided by RefSeq, Jul 2010)

GeneCards Summary for EGFR Gene: 
EGFR (epidermal growth factor receptor) is a protein-coding gene. Diseases associated with EGFR include lung cancer, and paronychia, and among its related super-pathways are ErbB signaling pathway and Glioma. GO annotations related to this gene include enzyme binding and protein heterodimerization activity. An important paralog of this gene is SYK.

UniProtKB/Swiss-Prot: EGFR_HUMAN, P00533
Function: Receptor tyrosine kinase binding ligands of the EGF family and activating several signaling cascades to
convert extracellular cues into appropriate cellular responses. Known ligands include EGF, TGFA/TGF-alpha,
amphiregulin, epigen/EPGN, BTC/betacellulin, epiregulin/EREG and HBEGF/heparin-binding EGF. Ligand binding
triggers receptor homo- and/or heterodimerization and autophosphorylation on key cytoplasmic residues. The
phosphorylated receptor recruits adapter proteins like GRB2 which in turn activates complex downstream signaling
cascades. Activates at least 4 major downstream signaling cascades including the RAS-RAF-MEK-ERK, PI3 kinase-AKT,
PLCgamma-PKC and STATs modules. May also activate the NF-kappa-B signaling cascade. Also directly phosphorylates
other proteins like RGS16, activating its GTPase activity and probably coupling the EGF receptor signaling to the
G protein-coupled receptor signaling. Also phosphorylates MUC1 and increases its interaction with SRC and
CTNNB1/beta-catenin
Function: Isoform 2 may act as an antagonist of EGF action

summary for EGFR Gene:
The epidermal growth factor receptor (EGFR) is a receptor tyrosine kinase of the ErbB family. Four members
of the ErbB family have been identified; EGFR (ErbB1, HER1), ErbB2 (HER2), ErbB3 (HER3) and ErbB4 (HER4).
EGFR signaling is initiated by ligand binding to the extracellular ligand binding domain. This initiates
receptor homo-/hetero-dimerization and autophosphorylation by the intracellular kinase domain, resulting in
receptor activation. Following activation, phosphorylation of cytoplasmic substrates occurs and a signaling
cascade is initiated that drives many cellular responses, including changes in gene expression, cytoskeletal
rearrangement, anti-apoptosis and increased cell proliferation.

Gene Wiki entry for EGFR (Epidermal growth factor receptor) Gene

PharmGKB "VIP" summary for EGFR


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000007.13  NT_033968.6  NC_018918.2  NT_079592.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the EGFR gene promoter:
         Max1   p53   STAT3   c-Myc   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 6): EGFR promoter sequence
   Search SABiosciences Chromatin IP Primers for EGFR

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat EGFR


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 7p12   Ensembl cytogenetic band:  7p11.2   HGNC cytogenetic band: 7p12

EGFR Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
EGFR gene location

GeneLoc information about chromosome 7         GeneLoc Exon Structure

GeneLoc location for GC07P055054:  view genomic region     (about GC identifiers)

Start:
55,086,714 bp from pter      End:
55,324,313 bp from pter
Size:
237,600 bases      Orientation:
plus strand

1 alternative location:
Chr7+,CRA_TCAG 55,092,507-55,280,831     

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: EGFR_HUMAN, P00533 (See protein sequence)
Recommended Name: Epidermal growth factor receptor precursor  
Size: 1210 amino acids; 134277 Da
Subunit: Binding of the ligand triggers homo- and/or heterodimerization of the receptor triggering its
autophosphorylation. Heterodimer with ERBB2. Interacts with ERRFI1; inhibits dimerization of the kinase domain
and autophosphorylation. Part of a complex with ERBB2 and either PIK3C2A or PIK3C2B. Interacts with GRB2; an
adapter protein coupling the receptor to downstream signaling pathways. Interacts with GAB2; involved in
signaling downstream of EGFR. Interacts with STAT3; mediates EGFR downstream signaling in cell proliferation.
Interacts with RIPK1; involved in NF-kappa-B activation. Interacts (autophosphorylated) with CBL; involved in
EGFR ubiquitination and regulation. Interacts with SOCS5; regulates EGFR degradation through TCEB1- and
TCEB2-mediated ubiquitination and proteasomal degradation. Interacts with PRMT5; methylates EGFR and enhances
interaction with PTPN6. Interacts (phosphorylated) with PTPN6; inhibits EGFR-dependent activation of MAPK/ERK.
Interacts with COPG1; essential for regulation of EGF-dependent nuclear transport of EGFR by retrograde
trafficking from the Golgi to the ER. Interacts with TNK2; this interaction is dependent on EGF stimulation and
kinase activity of EGFR. Interacts with PCNA; positively regulates PCNA. Interacts with PELP1. Interacts with
MUC1. Interacts with AP2M1. Interacts with FER. May interact with EPS8; mediates EPS8 phosphorylation. Interacts
(via SH2 domains) with GRB2, NCK1 and NCK2. Interacts with ATX2. Interacts with GAREM
Subcellular location: Cell membrane; Single-pass type I membrane protein. Endoplasmic reticulum membrane;
Single-pass type I membrane protein. Golgi apparatus membrane; Single-pass type I membrane protein. Nucleus
membrane; Single-pass type I membrane protein. Endosome. Endosome membrane. Note=In response to EGF, translocated
from the cell membrane to the nucleus via Golgi and ER. Endocytosed upon activation by ligand
Subcellular location: Isoform 2: Secreted
6/80 PDB 3D structures from and Proteopedia for EGFR (see all 80):
1DNQ (3D)        1DNR (3D)        1IVO (3D)        1M14 (3D)        1M17 (3D)        1MOX (3D)    
Secondary accessions: O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9
Q9UMD7 Q9UMD8 Q9UMG5
Alternative splicing: 4 isoforms:  P00533-1   P00533-2   P00533-3   P00533-4   

Explore the universe of human proteins at neXtProt for EGFR: NX_P00533

Explore proteomics data for EGFR at MOPED 

Post-translational modifications:

  • UniProtKB: Phosphorylation at Ser-695 is partial and occurs only if Thr-693 is phosphorylated. Phosphorylation at Thr-678 and
    Thr-693 by PRKD1 inhibits EGF-induced MAPK8/JNK1 activation. Dephosphorylation by PTPRJ prevents endocytosis and
    stabilizes the receptor at the plasma membrane. Autophosphorylation at Tyr-1197 is stimulated by methylation at
    Arg-1199 and enhances interaction with PTPN6. Autophosphorylation at Tyr-1092 and/or Tyr-1110 recruits STAT3
  • UniProtKB: Monoubiquitinated and polyubiquitinated upon EGF stimulation; which does not affect tyrosine kinase activity or
    signaling capacity but may play a role in lysosomal targeting. Polyubiquitin linkage is mainly through 'Lys-63',
    but linkage through 'Lys-48', 'Lys-11' and 'Lys-29' also occurs. Deubiquitination by OTUD7B prevents degradation
  • UniProtKB: Methylated. Methylation at Arg-1199 by PRMT5 stimulates phosphorylation at Tyr-1197
  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_P00533

  • 4/27 DME Specific Peptides for EGFR (P00533) (see all 27)
     KPYDGIP  YGVTVWE  RDLAARN  RYLVIQG 

    EGFR Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    EGFR Protein Expression
    REFSEQ proteins (4 alternative transcripts): 
    NP_005219.2  NP_958439.1  NP_958440.1  NP_958441.1  

    ENSEMBL proteins: 
     ENSP00000415559   ENSP00000342376   ENSP00000345973   ENSP00000413843   ENSP00000275493  
     ENSP00000413354   ENSP00000410031   ENSP00000395243  
    Reactome Protein details: P00533
    Human Recombinant Protein Products for EGFR: 
    EMD Millipore Purified and/or Recombinant EGFR Protein
    R&D Systems Recombinant & Natural Proteins for EGFR (EGF R/ErbB1)
    Enzo Life Sciences proteins for EGFR
    OriGene Purified Proteins for EGFR
    OriGene Protein Over-expression Lysate for EGFR
    OriGene MassSpec for EGFR 
    OriGene Custom Protein Services for EGFR
    GenScript Custom Purified and Recombinant Proteins Services for EGFR
    Novus Biologicals EGFR Proteins
    Novus Biologicals EGFR Lysates
    Sino Biological Recombinant Protein for EGFR
    Sino Biological Cell Lysate for EGFR 
    ProSpec Recombinant Protein for EGFR
    Cloud-Clone Corp. Proteins for EGFR 

    Gene Ontology (GO): 5/18 cellular component terms (GO ID links to tree view) (see all 18):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000139Golgi membrane IEA--
    GO:0005615extracellular space NAS9103388
    GO:0005622intracellular ----
    GO:0005634nucleus IDA12828935
    GO:0005737cytoplasm IDA--

    EGFR for ontologies           About GeneDecksing



    EGFR Antibody Products: 
    EMD Millipore Mono- and Polyclonal Antibodies for the study of EGFR
    R&D Systems Antibodies for EGFR (EGF R/ErbB1)
    Cell Signaling Technology (CST) Antibodies for EGFR 
    OriGene Antibodies for EGFR
    OriGene Custom Antibody Services for EGFR
    GenScript Superior Antibodies for EGFR
    Novus Biologicals EGFR Antibodies
    Abcam antibodies for EGFR
    Cloud-Clone Corp. Antibodies for EGFR 
    ThermoFisher Antibody for EGFR
    LSBio Antibodies in human, mouse, rat for EGFR 

    Assay Products for EGFR: 
    EMD Millipore Kits and Assays for the Analysis of EGFR
    OriGene Custom Assay Services for EGFR
    R&D Systems ELISAs for EGFR (EGF R/ErbB1)         (see all)
    GenScript EGFR-Activity-based Kinase Assay for Compound Screening
    Cell Signaling Technology (CST) Sandwich ELISA Kits for EGFR
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for EGFR 
    Cloud-Clone Corp. CLIAs for EGFR


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    IUPHAR Guide to PHARMACOLOGY protein family classification: epidermal growth factor receptor 
    ErbB (epidermal growth factor) receptor family

    5/11 InterPro protein domains (see all 11):
     IPR017441 Protein_kinase_ATP_BS
     IPR006212 Furin_repeat
     IPR000494 EGF_rcpt_L
     IPR001245 Ser-Thr/Tyr_kinase_cat_dom
     IPR009030 Growth_fac_rcpt_N_dom

    Graphical View of Domain Structure for InterPro Entry P00533

    ProtoNet protein and cluster: P00533

    4 Blocks protein domains:
    IPB000494 Epidermal growth-factor receptor (EGFR)
    IPB006211 Furin-like cysteine rich region
    IPB006212 Furin-like repeat
    IPB008266 Tyrosine protein kinase


    UniProtKB/Swiss-Prot: EGFR_HUMAN, P00533
    Similarity: Belongs to the protein kinase superfamily. Tyr protein kinase family. EGF receptor subfamily
    Similarity: Contains 1 protein kinase domain


    EGFR for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: EGFR_HUMAN, P00533
    Function: Receptor tyrosine kinase binding ligands of the EGF family and activating several signaling cascades to
    convert extracellular cues into appropriate cellular responses. Known ligands include EGF, TGFA/TGF-alpha,
    amphiregulin, epigen/EPGN, BTC/betacellulin, epiregulin/EREG and HBEGF/heparin-binding EGF. Ligand binding
    triggers receptor homo- and/or heterodimerization and autophosphorylation on key cytoplasmic residues. The
    phosphorylated receptor recruits adapter proteins like GRB2 which in turn activates complex downstream signaling
    cascades. Activates at least 4 major downstream signaling cascades including the RAS-RAF-MEK-ERK, PI3 kinase-AKT,
    PLCgamma-PKC and STATs modules. May also activate the NF-kappa-B signaling cascade. Also directly phosphorylates
    other proteins like RGS16, activating its GTPase activity and probably coupling the EGF receptor signaling to the
    G protein-coupled receptor signaling. Also phosphorylates MUC1 and increases its interaction with SRC and
    CTNNB1/beta-catenin
    Function: Isoform 2 may act as an antagonist of EGF action
    Catalytic activity: ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate
    Enzyme regulation: Endocytosis and inhibition of the activated EGFR by phosphatases like PTPRJ and PTPRK
    constitute immediate regulatory mechanisms. Upon EGF-binding phosphorylates EPS15 that regulates EGFR endocytosis
    and activity. Moreover, inducible feedback inhibitors including LRIG1, SOCS4, SOCS5 and ERRFI1 constitute
    alternative regulatory mechanisms for the EGFR signaling

         Genatlas biochemistry entry for EGFR:
    epidermal growth factor receptor,also binding transforming growth factor alpha (TGFA),involved in early
    craniofacial development and palate closure,phosphorylating GJB1,amplified in prostate carcinoma and in
    astrocytomas,deleted in glioblastomas and mutated in malignant oral keratinocytes

         Enzyme Numbers (IUBMB): EC 2.7.10.11 2 EC 2.7.102

         Gene Ontology (GO): 5/20 molecular function terms (GO ID links to tree view) (see all 20):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003682chromatin binding IDA--
    GO:0003690double-stranded DNA binding NAS6325948
    GO:0004672protein kinase activity ----
    GO:0004709MAP kinase kinase kinase activity NAS15542601
    GO:0004713protein tyrosine kinase activity TAS16076471
         
    EGFR for ontologies           About GeneDecksing


    Phenotypes:
         6 GenomeRNAi human phenotypes for EGFR:
     Decreased focal adhesion (FA)   Decreased p24 protein expressi  Decreased substrate adherent c  Decreased viability with pacli 
     Increased S DNA content  Increased cell death HMECs cel 

         15/27 MGI mutant phenotypes (inferred from 14 alleles(MGI details for Egfr) (see all 27):
     adipose tissue  cardiovascular system  cellular  craniofacial  digestive/alimentary 
     embryogenesis  endocrine/exocrine gland  growth/size  hearing/vestibular/ear  hematopoietic system 
     homeostasis/metabolism  immune system  integument  limbs/digits/tail  liver/biliary system 

    EGFR for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-outs for EGFR: Egfrtm1Arge Egfrtm1Rdk Egfrtm1.1Dwt Egfrtm1Mag

       inGenious Targeting Laboratory - Custom generated mouse model solutions for EGFR 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for EGFR

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for EGFR 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for EGFR 

    miRNA
    Products:
        
    miRTarBase miRNAs that target EGFR:
    hsa-mir-146a (MIRT004730), hsa-mir-21 (MIRT005807), hsa-mir-7 (MIRT002289), hsa-mir-16 (MIRT001470), hsa-mir-128 (MIRT004353), hsa-mir-1 (MIRT001370)

    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat EGFR
    8/17 QIAGEN miScript miRNA Assays for microRNAs that regulate EGFR (see all 17):
    hsa-miR-579 hsa-miR-607 hsa-miR-186* hsa-miR-586 hsa-miR-875-5p hsa-miR-27a hsa-miR-548o hsa-miR-545
    SwitchGear 3'UTR luciferase reporter plasmidEGFR 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for EGFR
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat EGFR

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for EGFR
    Sirion Biotech Validated adenovirus to knockdown EGFR in human, mouse 
                         Customized adenovirus for overexpression of EGFR

    Clone
    Products:
         
    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene clones in human, mouse for EGFR (see all 25)
    OriGene ORF clones in mouse, rat for EGFR
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 4): EGFR (NM_201282)
    Sino Biological Human cDNA Clone for EGFR
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for EGFR
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat EGFR
    Sirion Biotech Customized lentivirus for stable overexpression of EGFR 
                         Customized lentivirus expression plasmids for stable overexpression of EGFR 

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for EGFR
    Search LifeMap BioReagents cell lines for EGFR
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for EGFR


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for EGFR About   (see all 106)                                                                                              See pathways by source

    SuperPathSelected contained pathways About (see all per SuperPath)
    1ErbB signaling pathway
    ErbB signaling pathway0.52
    EGFR Inhibitor Pathway, Pharmacodynamics0.49
    ErbB signaling pathway0.52
    2Glioma
    Glioma0.51
    Prostate cancer0.39
    Non-small cell lung cancer0.51
    Signaling Pathways in Glioblastoma0.36
    Melanoma0.43
    Bladder cancer0.31
    3SHC-mediated signalling
    GRB2 events in EGFR signaling0.93
    Signaling by constitutively active EGFR0.31
    SHC1 events in EGFR signaling0.93
    EGFR-dependent Endothelin signaling events0.31
    EGFR Transactivation by Gastrin0.35
    4Development Dopamine D2 receptor transactivation of EGFR
    Development Dopamine D2 receptor transactivation of EGFR0.66
    Apoptosis and survival BAD phosphorylation0.41
    Development Alpha-2 adrenergic receptor activation of ERK0.66
    BAD Phosphorylation0.41
    5SHC1 events in ERBB2 signaling
    SHC1 events in ERBB2 signaling0.92
    ErbB receptor signaling network0.34
    GRB2 events in ERBB2 signaling0.92

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    5/22 EMD Millipore Pathways for EGFR (see all 22)
        Transcription Androgen Receptor nuclear signaling
    Cell adhesion PLAU signaling
    Development Ligand-independent activation of ESR1 and ESR2
    Development EGFR signaling via PIP3
    Translation Regulation activity of EIF2

    1 R&D Systems Pathway for EGFR
        Akt Signaling Pathway

    5/78 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for EGFR (see all 78)
        Telomerase Components in Cell Signaling
    UVB-Induced MAPK Signaling
    Molecular Mechanisms of Cancer
    eIF2 Pathway
    Intracellular Calcium Signaling

    1 Cell Signaling Technology (CST) Pathway for EGFR
        Tyrosine Kinases / Adaptors

    4 Tocris Bioscience Pathways for EGFR
        Akt Pathway
    Apoptosis Pathway
    NF-kappaB Pathway
    MAPK Pathway

    5/24 GeneGo (Thomson Reuters) Pathways for EGFR (see all 24)
        Development Endothelin-1/EDNRA transactivation of EGFR
    Development EGFR signaling pathway
    Mucin expression in CF via TLRs, EGFR signaling pathways
    Development ERBB-family signaling
    Cell adhesion PLAU signaling

    5/31 BioSystems Pathways for EGFR (see all 31)
        MAPK signaling pathway
    Focal Adhesion
    EGFR1 Signaling Pathway
    ErbB signaling pathway
    Integrated Breast Cancer Pathway

    1 Sino Biological Pathway for EGFR 
        EGFR Signaling Pathway

    5/46        Reactome Pathways for EGFR (see all 46)
        L1CAM interactions
    Signaling by EGFR in Cancer
    EGFR Transactivation by Gastrin
    Signal transduction by L1
    Downstream signal transduction

    3 PharmGKB Pathways for EGFR
        EGFR Inhibitor Pathway, Pharmacodynamics
    Erlotinib Pathway, Pharmacokinetics
    Vemurafenib Pathway, Pharmacodynamics

    5/26         Kegg Pathways  (Kegg details for EGFR) (see all 26):
        MAPK signaling pathway
    ErbB signaling pathway
    Calcium signaling pathway
    Cytokine-cytokine receptor interaction
    HIF-1 signaling pathway


    EGFR for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for EGFR

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/725 Interacting proteins for EGFR (P005331, 2, 3 ENSP000002754934) via UniProtKB, MINT, STRING, and/or I2D (see all 725)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    GRB2P629931, 2, 3, ENSP000003390074EBI-297353,EBI-401755 MINT-8029342 MINT-8029357 MINT-74541 MINT-61494 MINT-8029326 MINT-58642 MINT-8029310 MINT-1793777 MINT-61502 MINT-8029261 MINT-61540 MINT-8038388 MINT-6169986 MINT-61498 MINT-8038373 MINT-8401377 MINT-61500 MINT-58641 MINT-61496 MINT-8029372 MINT-6805737 MINT-58640 MINT-61497 MINT-8029231 I2D: score=8 STRING: ENSP00000339007
    ENSG00000237724P081071, 3, ENSP000004063594EBI-297353,EBI-629985 I2D: score=3 STRING: ENSP00000406359
    HSPA1AP081071, 3, ENSP000003648024EBI-297353,EBI-629985 I2D: score=3 STRING: ENSP00000364802
    ENSG00000212866P081071, 3EBI-297353,EBI-629985 I2D: score=3 
    ENSG00000224501P081071, 3EBI-297353,EBI-629985 I2D: score=3 
    About this table

    Gene Ontology (GO): 5/52 biological process terms (GO ID links to tree view) (see all 52):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000165MAPK cascade NAS15542601
    GO:0000186activation of MAPKK activity NAS15542601
    GO:0000902cell morphogenesis ----
    GO:0001503ossification NAS12925580
    GO:0001892embryonic placenta development IEA--

    EGFR for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    EGFR for compounds           About GeneDecksing

    EMD Millipore small molecules for EGFR:
    Small Molecule - inhibitor
    Enzo Life Sciences drugs & compounds for EGFR

    Compounds for EGFR available from Tocris Bioscience    About this table
    CompoundAction CAS #
    Iressa Orally active, selective EGFR inhibitor [184475-35-2]
    AG 490 EGFR-kinase inhibitor. Also JAK2, JAK3 inhibitor [133550-30-8]
    JNJ 28871063 hydrochloridePotent ErbB receptor family inhibitor[944341-54-2]
    AG 1478 hydrochlorideHighly potent EGFR-kinase inhibitor[153436-53-4]
    GenisteinEGFR kinase inhibitor. Also estrogen and PPARgamma ligand[446-72-0]

    4 HMDB Compounds for EGFR    About this table
    CompoundSynonyms CAS #PubMed Ids
    Aldosterone(+)-Aldosterone (see all 22)52-39-117681751
    ADPadenosindiphosphorsaeure (see all 8)58-64-0--
    Adenosine triphosphate5'-(tetrahydrogen triphosphate) Adenosine (see all 24)56-65-5--
    L-Tyrosine(-)-a-Amino-p-hydroxyhydrocinnamate (see all 28)60-18-4--

    10/12 DrugBank Compounds for EGFR (see all 12)    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    LapatinibFMM (see all 5)388082-78-8targetantagonist15163842 14751502 16894399 20110044 12214266 18803986 14967461 14737100 11752352 20658522 15374980 14633707
    Panitumumab-- 339177-26-3targetsuppressor12620146 11894013 20481659 18343240 16012181 14967460 18503402 16857825 17355997 11752352 20623992 11255078
    CetuximabAnti EGFR (see all 2)205923-56-4targetantagonist10480573 11408594 11752352 11431346 10628369 10601294
    ErlotinibCP358774 (see all 2)183321-74-6targetantagonist12517254 12814826 12820772 11752352 12840797 12498017
    Gefitinib-- 184475-35-2targetantagonist11585753 11566608 11752352 11522647 10815932 11673690
    FlavopiridolAlvocidib (see all 5)131740-09-5target--11752352
    LidocaineDilocaine (see all 2)137-58-6targetantagonist16551906
    N-[4-(3-BROMO-PHENYLAMINO)-QUINAZOLIN-6-YL]-ACRYLAMIDE-- --target--10592235
    S-{3-[(4-ANILINOQUINAZOLIN-6-YL)AMINO]-3-OXOPROPYL}-L-CYSTEINE-- --target--10592235
    TrastuzumabAnti HER2 (see all 2)180288-69-1target--11752352

    7 IUPHAR Ligands for EGFR (epidermal growth factor receptor)    About this table 
    LigandTypeActionAffinityPubmed IDs
    EGF
    NoneNone--
    betacellulin
    NoneNone--
    epiregulin
    NoneNone--
    HB-EGF
    NoneNone--
    amphiregulin
    NoneNone--
    TGFα
    NoneNone--
    epigen
    NoneNone--

    10/119 Novoseek inferred chemical compound relationships for EGFR gene (see all 119)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    gefitinib 97.2 2922 17361439 (8), 16106023 (7), 16818686 (7), 16956694 (7) (see all 99)
    erlotinib 96.4 1156 16818686 (7), 17453292 (7), 16928826 (6), 19130057 (6) (see all 99)
    cetuximab 95.9 1196 12850474 (7), 16106023 (7), 20010090 (6), 17531336 (6) (see all 99)
    tyrosine 93.9 4999 16263724 (9), 16287490 (8), 12589790 (7), 10068444 (6) (see all 99)
    ag 1478 93.3 467 14676326 (5), 19947936 (5), 17092939 (4), 19816982 (4) (see all 99)
    panitumumab 92 186 17671148 (2), 18086972 (2), 20044619 (2), 18343240 (2) (see all 99)
    lapatinib 88.2 334 17635524 (6), 18644997 (5), 18199554 (5), 19529774 (4) (see all 99)
    pd153035 88 105 16211241 (2), 17934341 (2), 10473113 (2), 15562758 (2) (see all 60)
    zd6474 85.6 171 15604279 (8), 12684431 (5), 17145834 (4), 16688779 (3) (see all 67)
    trastuzumab 85.3 164 19188134 (5), 16161043 (4), 17622245 (4), 16163699 (2) (see all 95)

    10/11 PharmGKB related drug/compound annotations for EGFR gene (see all 11)    About this table
    Drug/compound PharmGKB Annotation
    Alkylating AgentsCA  
    carboplatinCA  
    cetuximab  CA  
    docetaxelCA  
    egfr inhibitorsCA  
    erlotinib  CA  
    gefitinib  CA  
    geldanamycinCA  
    gemcitabineCA  
    paclitaxelCA  

    Search CenterWatch for drugs/clinical trials and news about EGFR

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for EGFR gene (4 alternative transcripts): 
    NM_005228.3  NM_201282.1  NM_201283.1  NM_201284.1  

    Unigene Cluster for EGFR:

    Epidermal growth factor receptor
    Hs.488293  [show with all ESTs]
    Unigene Representative Sequence: NM_005228
    11 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000455089(uc022adm.1 uc010kzg.2 uc022ado.1) ENST00000342916(uc003tqi.3)
    ENST00000344576(uc003tqj.3) ENST00000420316(uc003tqh.3) ENST00000275493(uc003tqk.3 uc022adn.1 uc011kco.2)
    ENST00000459688 ENST00000463948 ENST00000450046 ENST00000485503 ENST00000442591(uc011kcq.1 uc011kcp.1)
    ENST00000454757
    Congresses - knowledge worth sharing:  
    European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

    miRNA
    Products:
         
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat EGFR
    8/17 QIAGEN miScript miRNA Assays for microRNAs that regulate EGFR (see all 17):
    hsa-miR-579 hsa-miR-607 hsa-miR-186* hsa-miR-586 hsa-miR-875-5p hsa-miR-27a hsa-miR-548o hsa-miR-545
    SwitchGear 3'UTR luciferase reporter plasmidEGFR 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for EGFR
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat EGFR
    Clone
    Products:
         
    OriGene clones in human, mouse for EGFR (see all 25)
    OriGene ORF clones in mouse, rat for EGFR
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 4): EGFR (NM_201282)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for EGFR
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat EGFR
    Sirion Biotech Customized lentivirus for stable overexpression of EGFR 
                         Customized lentivirus expression plasmids for stable overexpression of EGFR 
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for EGFR
    OriGene qSTAR qPCR primer pairs in human, mouse for EGFR
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat EGFR
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat EGFR
      Search QIAGEN QuantiFast Probe-based Assays in human, mouse, rat EGFR

    Additional mRNA sequence: 

    AB209442.1 AF125253.1 AF277897.1 AK225422.1 AK290352.1 AK294750.1 AY550966.1 AY698023.1 
    AY698024.1 BC070081.1 BC094761.1 BC118665.1 BC128419.1 BC134346.1 DQ088980.1 EF210210.1 
    EF210211.1 GU255993.1 HM437234.1 HM437235.1 HQ730875.1 HQ912715.1 HQ999997.1 K03193.1 
    U48722.1 U95089.1 X00588.1 X00663.1 

    21 DOTS entries:

    DT.97784849  DT.453606  DT.121058602  DT.86855651  DT.95165593  DT.101978019  DT.92446350  DT.100752430 
    DT.121058582  DT.91654361  DT.121058480  DT.121058532  DT.121058546  DT.121058650  DT.418647  DT.95254161 
    DT.97822681  DT.91963338  DT.95095929  DT.95165591  DT.95229256 

    24/484 AceView cDNA sequences (see all 484):

    AY698024 AI074153 BM768072 CA432352 BE745530 AA333063 BF432992 R79549 
    AI417511 CB268886 BQ575631 BQ637472 CR603510 AW261991 BM747582 AI950585 
    T39329 BX108964 AI278317 AA873091 AI301624 H80439 AU099322 X00663 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    EGFR expression in normal human tissues (normalized intensities)      EGFR embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CCCGCATTAG
    EGFR Expression
    About this image


    EGFR expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/23 selected tissues (see all 23) fully expand
     
     Neural Tube (Nervous System)    fully expand to see all 6 entries
             Metencephalon
             spinal cord/lateral wall/mantle layer   
     
     Brain (Nervous System)    fully expand to see all 4 entries
             Medulla Oblongata
             brain/midbrain/lateral wall   
     
     Heart (Cardiovascular System)    fully expand to see all 4 entries
             Semilunar Valve Cells Semilunar Valves
     
     Bone (Muscoskeletal System)    fully expand to see all 3 entries
             Mesenchymal Condensate Cells Zeugopod
             Thoracic Rib
             Bone marrow-derived mesenchymal stem cells
     
     Epidermis (Integumentary System)    fully expand to see all 3 entries
             Intermediate Keratinocytes Embryonic Epidermis
             Stratified Epidermis

    See EGFR Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for EGFR

    SOURCE GeneReport for Unigene cluster: Hs.488293

    UniProtKB/Swiss-Prot: EGFR_HUMAN, P00533
    Tissue specificity: Ubiquitously expressed. Isoform 2 is also expressed in ovarian cancers

        SABiosciences Expression via Pathway-Focused PCR Arrays including EGFR (see all 24): 
              Lung Cancer in human mouse rat
              Wound Healing in human mouse rat
              Nitric Oxide Signaling Pathway in human mouse rat
              Prostate Cancer in human mouse rat
              Cell Motility in human mouse rat

    Primer
    Products:
    OriGene qPCR primer pairs and template standards for EGFR
    OriGene qSTAR qPCR primer pairs in human, mouse for EGFR
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat EGFR
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat EGFR
    Search QIAGEN QuantiFast Probe-based Assays in human, mouse, rat EGFR
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for EGFR

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for EGFR gene from 5/13 species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Egfr1 , 5 epidermal growth factor receptor1, 5 85.13(n)1
    90.65(a)1
      11 (9.41 cM)5
    136491  NM_207655.21  NP_997538.11 
     167522035 
    chicken
    (Gallus gallus)
    Aves EGFR1 epidermal growth factor receptor 73.88(n)
    78.29(a)
      396494  NM_205497.2  NP_990828.2 
    lizard
    (Anolis carolinensis)
    Reptilia EGFR6
    Uncharacterized protein
    73(a)
    1 ↔ 1
    6(51109057-51161436)
    zebrafish
    (Danio rerio)
    Actinopterygii egfr2 epidermal growth factor receptor 75.84(n)   378478  AY154658.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Egfr3 eggshell pattern formation epidermal
    growth factor more
    40(a)     --


    ENSEMBL Gene Tree for EGFR (if available)
    TreeFam Gene Tree for EGFR (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for EGFR gene
    SYK2  TNK12  JAK32  JAK22  TNK22  TYK22  ERBB42  JAK12  
    ERBB32  PTK22  ERBB22  ZAP702  PTK2B2  
    18/64 SIMAP similar genes for EGFR using alignment to 29 protein entries:     EGFR_HUMAN (see all proteins) (see all similar genes):
    EPHA4    ERBB2    ERBB4    FLT4    MATK    ERBB3
    TXK    FGFR1    ABL1    RET/PTC2    DKFZp686M05208    c-erbB-3
    MAPK3    RPS6KA2    TNK2    HER-2    TYK2    JAK2

    EGFR for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/4546 SNPs in EGFR are shown (see all 4546)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 7 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs289294951,2,4
    Cpathogenic155247498(+) TGCTGA/G/TGCTCC 3 S G C mis1 ese30--------
    rs1219134281,2
    Cpathogenic155247499(+) GCTGGA/C/GCTCCG 3 D A G mis10--------
    rs1214345691,2
    Cpathogenic155254862(+) CATCAC/TGCAGC 2 T M mis10--------
    rs1048860121,2
    Cuntested155265277(+) ACACCA/G/TCAGCA 2 P syn11NA 4552
    rs1219134181,2
    Cunknown155248302(+) TCCTCA/G/TATGTG 3 N D Y mis10--------
    rs1214345681,2,4
    Cother155265306(+) TGGGCG/TGGCCA 2 R L mis10--------
    VAR_0260904
    ----see VAR_0260902 E K mis40--------
    VAR_0260854
    ----see VAR_0260852 E K mis40--------
    VAR_0260984
    ----see VAR_0260982 T M mis40--------
    VAR_0695054
    ----see VAR_0695052 L V mis40--------

    HapMap Linkage Disequilibrium report for EGFR (55086714 - 55324313 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 10/19 variations for EGFR (see all 19):    About this table     
    Variant IDTypeSubtypePubMed ID
    dgv1133e201CNV Deletion23290073
    esv2734425CNV Deletion23290073
    esv2734437CNV Deletion23290073
    esv2734441CNV Deletion23290073
    esv2734440CNV Deletion23290073
    esv2660266CNV Deletion23128226
    esv2590945CNV Insertion19546169
    nsv5753CNV Insertion18451855
    nsv515544CNV Loss19592680
    nsv5752CNV Loss18451855


    Human Gene Mutation Database (HGMD): EGFR
    5/56 SABiosciences Cancer Mutation PCR Assays for EGFR (see all 56):
    Cosmic IdAA Change
    13427p.E709A
    13551p.E746_T751>I
    6252p.G719S
    21687p.A289V
    21684p.T263P
    5/12 SABiosciences Cancer Mutation PCR Arrays containing EGFR (see all 12):
    Esophageal Cancer
    Cancer Comprehensive Panel 384HT
    Lung Cancer
    Oncogene Panel 384HT
    Receptor Tyrosine Kinase (RTK) (Panel I)
    4 SABiosciences qBiomarker Copy Number PCR Arrays containing EGFR:
    Oncogenes & Tumor Suppressor Genes 384HC
    Breast Cancer
    Lung Cancer
    Kinases & Phosphatases
    SeqTarget long-range PCR primers for resequencing EGFR
    DNA2.0 Custom Variant and Variant Library Synthesis for EGFR

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 131550   
    OMIM disorders: 211980  
    UniProtKB/Swiss-Prot: EGFR_HUMAN, P00533
  • Lung cancer (LNCR) [MIM:211980]: A common malignancy affecting tissues of the lung. The most common form
    of lung cancer is non-small cell lung cancer (NSCLC) that can be divided into 3 major histologic subtypes:
    squamous cell carcinoma, adenocarcinoma, and large cell lung cancer. NSCLC is often diagnosed at an advanced
    stage and has a poor prognosis. Note=The gene represented in this entry is involved in disease pathogenesis

  • 20/298 diseases for EGFR (see all 298):    About MalaCards
    lung cancer    paronychia    brain ependymoma    nonsmall cell lung cancer, response to tyrosine kinase inhibitor in
    lung cancer, egfr-related    adenocarcinoma of lung, response to tyrosine kinase inhibitor in    intraocular melanoma    troyer syndrome
    ring chromosome 7    lymphangitis    ethmoid sinusitis    ethmoid sinus adenocarcinoma
    lung adenocarcinoma    brain cancer    invasive bladder transitional cell carcinoma    hidradenocarcinoma
    lung cancer, somatic    bladder transitional cell carcinoma    transitional cell carcinoma    adenosquamous carcinoma

    20 diseases from the University of Copenhagen DISEASES database for EGFR:
    Lung cancer     Breast cancer     Carcinoma     Exanthem
    Colorectal cancer     Malignant glioma     Diarrhea     Pancreatic cancer
    Ovarian cancer     Urinary bladder cancer     Prostate cancer     Neutropenia
    Ductal carcinoma in situ     Lung disease     Folliculitis     Esophageal cancer
    Brain cancer     Cervical cancer     Laryngeal carcinoma     Renal cell carcinoma

    EGFR for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:  
    Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015

    10/97 Novoseek inferred disease relationships for EGFR gene (see all 97)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    nsclc 91.1 3311 18710625 (7), 16106023 (6), 15777970 (6), 18347146 (6) (see all 99)
    tumors 87.7 6585 14967457 (9), 11727256 (8), 8151316 (8), 18450321 (8) (see all 99)
    glioblastoma 85 799 11511795 (7), 15618223 (6), 10728703 (6), 10029453 (5) (see all 99)
    cancer 84.6 2745 11597399 (7), 1717146 (5), 16378905 (5), 17827454 (5) (see all 99)
    cancer lung 84.4 1481 12720099 (7), 19331130 (6), 16226114 (6), 17876048 (5) (see all 99)
    carcinoma squamous cell 83.6 957 9828815 (5), 16550055 (5), 9816015 (5), 7970803 (5) (see all 99)
    adenocarcinoma lung 83.3 453 16357156 (5), 18508816 (5), 19130320 (5), 7599067 (4) (see all 99)
    breast cancer 82.5 1846 15095477 (8), 11859875 (8), 9066618 (6), 8960138 (6) (see all 99)
    glioblastoma multiforme 79.6 193 15746047 (4), 17236582 (4), 11504770 (4), 17679463 (3) (see all 99)
    adenocarcinoma 78.4 750 16449241 (11), 17321325 (5), 15211117 (5), 16052218 (5) (see all 99)

    Genatlas disease: EGFR
    glioblastoma,multiform (amplification of deleted/rearranged EGFR)

    Genetic Association Database (GAD): EGFR
    Human Genome Epidemiology (HuGE) Navigator: EGFR (572 documents)
    Tumor Gene Database (TGDB): EGFR

    Export disorders for EGFR gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for EGFR gene, integrated from 9 sources (see all 8011):
    (articles sorted by number of sources associating them with EGFR)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Molecular changes of epidermal growth factor receptor (EGFR) and KRAS and their impact on the clinical outcomes in surgically resected adenocarcinoma of the lung. (PubMed id 17904685)1, 4, 9 Kim Y.T....Kim J.H. (2008)
    2. Epidermal growth factor receptor mutation, but not sex and smoking, is independently associated with favorable prognosis of gefitinib-treated patients with lung adenocarcinoma. (PubMed id 18271929)1, 4, 9 Toyooka S....Date H. (2008)
    3. Prognostic significance of epidermal growth factor re ceptor phosphorylation and mutation in head and neck squamous cell carcinoma. (PubMed id 19726454)1, 4, 9 Hama T....Urashima M. (2009)
    4. Correlation of EGFR mutations with chromosomal alterations and expression of EGFR, ErbB3 and VEGF in tumor samples of lung adenocarcinoma patients. (PubMed id 18450321)1, 4, 9 Reinmuth N....Meister M. (2008)
    5. Are there imaging characteristics associated with epi dermal growth factor receptor and KRAS mutations in patients with adenocarcinom a of the lung with bronchioloalveolar features? (PubMed id 20087229)1, 4, 9 Glynn C....Ginsberg M.S. (2010)
    6. Epidermal growth factor receptor mutations and their correlation with gefitinib therapy in patients with non-small cell lung cancer: a meta-analysis based on updated individual patient data from six medical centers in mainland China. (PubMed id 17473659)1, 4, 9 Wu Y.L....Mok T. (2007)
    7. Epidermal growth factor receptor mutation status and adjuvant chemotherapy with uracil-tegafur for adenocarcinoma of the lung. (PubMed id 17761979)1, 4, 9 Suehisa H....Date H. (2007)
    8. A correlation between EGFR gene mutation status and bronchioloalveolar carcinoma features in Japanese patients with adenocarcinoma. (PubMed id 16449241)1, 4, 9 Haneda H....Fujii Y. (2006)
    9. Epidermal growth factor receptor copy number alterations correlate with poor clinical outcome in patients with head and neck squamous cancer. (PubMed id 17538160)1, 4, 9 Temam S....Mao L. (2007)
    10. Pancreatic cancer epidermal growth factor receptor (EGFR) intron 1 polymorphism influences postoperative patient survival and in vitro erlotinib response. (PubMed id 17453292)1, 4, 9 Tzeng C.W....Arnoletti J.P. (2007)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 1956 HGNC: 3236 AceView: EGFR Ensembl:ENSG00000146648 euGenes: HUgn1956
    ECgene: EGFR Kegg: 1956 H-InvDB: EGFR

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for EGFR Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for EGFR Genetics and Cytogenetics in Oncology and Haematology
    GeneReviewshttp://www.ncbi.nlm.nih.gov/sites/GeneTests/lab/gene/EGFR
    NIEHS-SNPshttp://egp.gs.washington.edu/data/egfr/
    Wikipedia http://en.wikipedia.org/wiki/Epidermal_growth_factor_receptor

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for EGFR gene:
    Search GeneIP for patents involving EGFR

    Licensable Technologies for EGFR gene:
    Weizmann Institute:Combination of Antibodies to EGFR
    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

     Browse for Gene Knock-down Tools from EMD Millipore
     EMD Millipore small molecules (inhibitor) for EGFR
     Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
     EMD Millipore Purified and/or Recombinant EGFR Protein
     EMD Millipore Kits and Assays for the Analysis of EGFR
     EMD Millipore Mono- and Polyclonal Antibodies for the study of EGFR
     
     EMD Millipore Custom Antibody & Bulk Services
     EMD Millipore Preclinical / Clinical Development Services
     EMD Millipore Immunoassay Services
     EMD Millipore Target Screening & Profiling Services

      
     Antibodies for EGFR (EGF R/ErbB1)   Browse Cell Culture Products  
     ELISAs for EGFR (EGF R/ErbB1)   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Kinase Activity Assays/Reagents  
     Browse ELISpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Multiplex/Array Assay Kits/Reagents  
     Cell Selection/Detection Kits/Reagents for EGFR (EGF R/ErbB1)   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Protease Activity Assays and Reagents   Recombinant/Natural Proteins for EGFR (EGF R/ErbB1)  
     Browse Stem Cell Products   Browse Tocris Biochemicals & Compounds  
     Browse cDNA Clones   Proteome Profiler Antibody Arrays for EGFR (EGF R/ErbB1)  
     OriGene Antibodies for EGFR   OriGene RNAi products in human, mouse, rat for EGFR  
     OriGene qPCR primer pairs and template standards for EGFR   OriGene Protein Over-expression Lysate for EGFR  
     OriGene MassSpec something-or-other for EGFR   OriGene clones in human, mouse for EGFR  
     OriGene qSTAR qPCR primer pairs in human, mouse for EGFR   OriGene Purified Protein for EGFR  
     OriGene ORF clones in mouse, rat for EGFR   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for EGFR   OriGene Custom Protein Services for EGFR  

     
     
     QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat EGFR
     QIAGEN SeqTarget long-range PCR primers for resequencing EGFR
     QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat EGFR
     QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat EGFR
     Search QIAGEN QuantiFast Probe-based Assays in human, mouse, rat EGFR
     QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat EGFR
     GenScript Custom Purified and Recombinant Proteins Services for EGFR GenScript cDNA clones with any tag delivered in your preferred vector for EGFR
     GenScript EGFR-Activity-based Kinase Assay for Compound Screening GenScript Superior Antibodies for EGFR
     GenScript Custom overexpressing Cell Line Services for EGFR CloneReady with Over 120,000 Genes
     Gene Synthesis: Any Gene in Any Vector Vector-based siRNA and miRNA, Ready for Transfection
     Gene Mutant Library, Variants up to 10^11 Plasmid Preparation
     Custom Peptide Services
     Antibodies & Assays for EGFR 

     Regulatory tfbs in EGFR promoter
     Search Chromatin IP Primers for EGFR
     RT2 qPCR Primer Assay in human, mouse, rat EGFR
     GNC Network for EGFR
     SABiosciences PCR Arrays including human, mouse, rat EGFR
     Tocris compounds for EGFR
     Proteins and Antibodies for EGFR
     Cell Lysates for EGFR
     cDNA Clones for EGFR
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Drugs/Proteins for EGFR
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
     Novus Tissue Slides
     EGFR antibodies
     EGFR proteins
     EGFR lysates
     Antibodies for EGFR
     See all of Abcam's Antibodies, Kits and Proteins for EGFR
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Recombinant Protein for EGFR




     Proteins for EGFR
     Antibodies for EGFR
     ELISAs for EGFR
     CLIAs for EGFR
     Search LifeMap BioReagents cell lines for EGFR
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for EGFR
     SwitchGear 3'UTR luciferase reporter plasmids for EGFR
     SwitchGear Promoter luciferase reporter plasmids for EGFR
     ThermoFisher Antibody for EGFR
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat EGFR
     inGenious Targeting Laboratory - Custom generated mouse model solutions for EGFR
     inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for EGFR
     Validated adenovirus to knockdown EGFR in human, mouse

    Customized:
     lentivirus for stable overexpression of EGFR
     lentivirus expression plasmids for stable overexpression of EGFR
     adenovirus for overexpression of EGFR
     LSBio Antibodies in human, mouse, rat for EGFR
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
           
    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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    Category
    (GIFtS: 73)
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    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


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