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Aliases for EGFR Gene

Aliases for EGFR Gene

  • Epidermal Growth Factor Receptor 2 3 5
  • Receptor Tyrosine-Protein Kinase ErbB-1 3 4
  • Erb-B2 Receptor Tyrosine Kinase 1 2 3
  • Proto-Oncogene C-ErbB-1 3 4
  • EC 2.7.10.1 4 61
  • ERBB1 3 4
  • ERBB 3 4
  • HER1 3 4
  • Epidermal Growth Factor Receptor (Avian Erythroblastic Leukemia Viral (V-Erb-B) Oncogene Homolog) 2
  • Erythroblastic Leukemia Viral (V-Erb-B) Oncogene Homolog (Avian) 2
  • Avian Erythroblastic Leukemia Viral (V-Erb-B) Oncogene Homolog 3
  • Cell Proliferation-Inducing Protein 61 3
  • Cell Growth Inhibiting Protein 40 3
  • EC 2.7.10 61
  • NISBD2 3
  • PIG61 3
  • MENA 3

External Ids for EGFR Gene

Previous HGNC Symbols for EGFR Gene

  • ERBB

Previous GeneCards Identifiers for EGFR Gene

  • GC07P054550
  • GC07P054794
  • GC07P054828
  • GC07P054860
  • GC07P055054

Summaries for EGFR Gene

Entrez Gene Summary for EGFR Gene

  • The protein encoded by this gene is a transmembrane glycoprotein that is a member of the protein kinase superfamily. This protein is a receptor for members of the epidermal growth factor family. EGFR is a cell surface protein that binds to epidermal growth factor. Binding of the protein to a ligand induces receptor dimerization and tyrosine autophosphorylation and leads to cell proliferation. Mutations in this gene are associated with lung cancer. [provided by RefSeq, Jun 2016]

GeneCards Summary for EGFR Gene

EGFR (Epidermal Growth Factor Receptor) is a Protein Coding gene. Diseases associated with EGFR include Inflammatory Skin And Bowel Disease, Neonatal, 2 and Giant Cell Glioblastoma. Among its related pathways are RET signaling and Internalization of ErbB1. GO annotations related to this gene include identical protein binding and protein kinase activity. An important paralog of this gene is ERBB4.

UniProtKB/Swiss-Prot for EGFR Gene

  • Receptor tyrosine kinase binding ligands of the EGF family and activating several signaling cascades to convert extracellular cues into appropriate cellular responses. Known ligands include EGF, TGFA/TGF-alpha, amphiregulin, epigen/EPGN, BTC/betacellulin, epiregulin/EREG and HBEGF/heparin-binding EGF. Ligand binding triggers receptor homo- and/or heterodimerization and autophosphorylation on key cytoplasmic residues. The phosphorylated receptor recruits adapter proteins like GRB2 which in turn activates complex downstream signaling cascades. Activates at least 4 major downstream signaling cascades including the RAS-RAF-MEK-ERK, PI3 kinase-AKT, PLCgamma-PKC and STATs modules. May also activate the NF-kappa-B signaling cascade. Also directly phosphorylates other proteins like RGS16, activating its GTPase activity and probably coupling the EGF receptor signaling to the G protein-coupled receptor signaling. Also phosphorylates MUC1 and increases its interaction with SRC and CTNNB1/beta-catenin. Plays a role in enhancing learning and memory performance (By similarity).

  • Isoform 2 may act as an antagonist of EGF action.

Tocris Summary for EGFR Gene

  • The epidermal growth factor receptor (EGFR) is a receptor tyrosine kinase of the ErbB family. Four members of the ErbB family have been identified; EGFR (ErbB1, HER1), ErbB2 (HER2), ErbB3 (HER3) and ErbB4 (HER4). EGFR signaling drives many cellular responses.

Gene Wiki entry for EGFR Gene

PharmGKB "VIP" Summary for EGFR Gene

No data available for fRNAdb sequence ontologies and piRNA Summary for EGFR Gene

Genomics for EGFR Gene

Regulatory Elements for EGFR Gene

Enhancers for EGFR Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH07F055060 1.5 FANTOM5 Ensembl ENCODE 19.9 +51.2 51235 19.4 HDGF PKNOX1 MLX WRNIP1 ZFP64 ARID4B SIN3A YBX1 FEZF1 DMAP1 EGFR EGFR-AS1 SEC61G GC07P055075
GH07F055124 1.2 FANTOM5 Ensembl ENCODE 17.8 +111.1 111121 11.3 PKNOX1 ZFP64 ARID4B SIN3A FEZF1 DMAP1 YBX1 ZNF48 ZNF207 FOS EGFR EGFR-AS1 SEC61G GC07P055075
GH07F055139 1.1 Ensembl ENCODE 17 +121.5 121531 2.4 TFAP4 MAX CEBPG EBF1 RAD21 ZBTB40 YY1 RELA SCRT2 SCRT1 EGFR EGFR-AS1 GC07P055075
GH07F055048 1.1 Ensembl ENCODE 16.4 +34.0 34029 9.9 SIN3A RAD21 RARA YY1 FOS CEBPB ZEB2 PPARG NR2F2 ZSCAN16 EGFR GC07P055075
GH07F054994 1.2 FANTOM5 Ensembl ENCODE 15.8 -23.1 -23140 1.9 ELF3 TBP HDAC1 PKNOX1 TBL1XR1 RAD21 BRCA1 RARA RFX5 GATA2 EGFR EGFR-AS1 LOC105375284
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around EGFR on UCSC Golden Path with GeneCards custom track

Promoters for EGFR Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000626721 979 3601 MLX SIN3A YBX1 GLIS2 FOS ZNF263 SP3 SP5 JUNB TBX21

Genomic Location for EGFR Gene

Chromosome:
7
Start:
55,019,021 bp from pter
End:
55,211,628 bp from pter
Size:
192,608 bases
Orientation:
Plus strand

Genomic View for EGFR Gene

Genes around EGFR on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
EGFR Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for EGFR Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for EGFR Gene

Proteins for EGFR Gene

  • Protein details for EGFR Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P00533-EGFR_HUMAN
    Recommended name:
    Epidermal growth factor receptor
    Protein Accession:
    P00533
    Secondary Accessions:
    • O00688
    • O00732
    • P06268
    • Q14225
    • Q68GS5
    • Q92795
    • Q9BZS2
    • Q9GZX1
    • Q9H2C9
    • Q9H3C9
    • Q9UMD7
    • Q9UMD8
    • Q9UMG5

    Protein attributes for EGFR Gene

    Size:
    1210 amino acids
    Molecular mass:
    134277 Da
    Quaternary structure:
    • Binding of the ligand triggers homo- and/or heterodimerization of the receptor triggering its autophosphorylation. Heterodimer with ERBB2. Interacts with ERRFI1; inhibits dimerization of the kinase domain and autophosphorylation. Part of a complex with ERBB2 and either PIK3C2A or PIK3C2B. Interacts with GRB2; an adapter protein coupling the receptor to downstream signaling pathways. Interacts with GAB2; involved in signaling downstream of EGFR. Interacts with STAT3; mediates EGFR downstream signaling in cell proliferation. Interacts with RIPK1; involved in NF-kappa-B activation. Interacts (autophosphorylated) with CBL, CBLB and CBLC; involved in EGFR ubiquitination and regulation. Interacts with SOCS5; regulates EGFR degradation through TCEB1- and TCEB2-mediated ubiquitination and proteasomal degradation. Interacts with PRMT5; methylates EGFR and enhances interaction with PTPN6. Interacts (phosphorylated) with PTPN6; inhibits EGFR-dependent activation of MAPK/ERK. Interacts with COPG1; essential for regulation of EGF-dependent nuclear transport of EGFR by retrograde trafficking from the Golgi to the ER. Interacts with TNK2; this interaction is dependent on EGF stimulation and kinase activity of EGFR. Interacts with PCNA; positively regulates PCNA. Interacts with PELP1. Interacts with MUC1. Interacts with AP2M1. Interacts with FER. May interact with EPS8; mediates EPS8 phosphorylation. Interacts (via SH2 domains) with GRB2, NCK1 and NCK2. Interacts with ATX2. Interacts with GAREM1. Interacts (ubiquitinated) with ANKRD13A/B/D; the interaction is direct and may regulate EGFR internalization after EGF stimulation. Interacts with GPER1; the interaction occurs in an estrogen-dependent manner. Interacts (via C-terminal cytoplasmic kinase domain) with ZPR1 (via zinc fingers). Interacts with RNF115 and RNF126. Interacts with GPRC5A (via its transmembrane domain)(PubMed:25311788). Interacts with FAM83B; positively regulates EGFR inducing its autophospharylation in absence of stimulation by EGF (PubMed:23912460).

    Three dimensional structures from OCA and Proteopedia for EGFR Gene

    Alternative splice isoforms for EGFR Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for EGFR Gene

Selected DME Specific Peptides for EGFR Gene

P00533:
  • GGKVPIKW
  • KPYDGIP
  • GPGLEGCP
  • QCAAGCTGP
  • LGLRSLKE
  • RDLAARN
  • LDEAYVMA
  • RLLGICLTS
  • MVKCWMID
  • MARDPQR
  • VKIPVAIK
  • GERLPQP
  • VHRDLAARNVLVKTPQHVKITDFGLAK
  • SDVWSYGVT
  • YGVTVWE
  • LLNWCVQIAKGM
  • TLVWKYADA
  • LREATSPK
  • RYLVIQG
  • TCKDTCPP
  • YTHQSDVWS
  • GERLPQPPICTI
  • EHKDNIGSQ
  • SPSTSRTPLLSSLSATSNNS
  • IDGPHCVK
  • ELVEPLTPSG
  • AARNVLV

Post-translational modifications for EGFR Gene

  • Methylated. Methylation at Arg-1199 by PRMT5 stimulates phosphorylation at Tyr-1197.
  • Monoubiquitinated and polyubiquitinated upon EGF stimulation; which does not affect tyrosine kinase activity or signaling capacity but may play a role in lysosomal targeting. Polyubiquitin linkage is mainly through Lys-63, but linkage through Lys-48, Lys-11 and Lys-29 also occurs. Deubiquitination by OTUD7B prevents degradation. Ubiquitinated by RNF115 and RNF126 (By similarity).
  • Phosphorylation at Ser-695 is partial and occurs only if Thr-693 is phosphorylated. Phosphorylation at Thr-678 and Thr-693 by PRKD1 inhibits EGF-induced MAPK8/JNK1 activation. Dephosphorylation by PTPRJ prevents endocytosis and stabilizes the receptor at the plasma membrane. Autophosphorylation at Tyr-1197 is stimulated by methylation at Arg-1199 and enhances interaction with PTPN6. Autophosphorylation at Tyr-1092 and/or Tyr-1110 recruits STAT3. Dephosphorylated by PTPN1 and PTPN2.
  • Ubiquitination at Lys 716, Lys 737, Lys 754, Lys 860, Lys 867, Lys 929, and Lys 970
  • Glycosylation at Asn 56, Asn 73, Asn 128, Asn 175, Asn 196, Asn 352, Asn 361, Asn 413, Asn 444, Asn 528, Asn 568, Asn 603, and Asn 623
  • Modification sites at PhosphoSitePlus

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for EGFR (EGFR)

Domains & Families for EGFR Gene

Graphical View of Domain Structure for InterPro Entry

P00533

UniProtKB/Swiss-Prot:

EGFR_HUMAN :
  • Contains 1 protein kinase domain.
  • Belongs to the protein kinase superfamily. Tyr protein kinase family. EGF receptor subfamily.
Domain:
  • Contains 1 protein kinase domain.
Family:
  • Belongs to the protein kinase superfamily. Tyr protein kinase family. EGF receptor subfamily.
genes like me logo Genes that share domains with EGFR: view

Function for EGFR Gene

Molecular function for EGFR Gene

GENATLAS Biochemistry:
epidermal growth factor receptor,also binding transforming growth factor alpha (TGFA),involved in early craniofacial development and palate closure,phosphorylating GJB1,amplified in prostate carcinoma and in astrocytomas,deleted in glioblastomas and mutated in malignant oral keratinocytes
UniProtKB/Swiss-Prot CatalyticActivity:
ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.
UniProtKB/Swiss-Prot EnzymeRegulation:
Endocytosis and inhibition of the activated EGFR by phosphatases like PTPRJ and PTPRK constitute immediate regulatory mechanisms. Upon EGF-binding phosphorylates EPS15 that regulates EGFR endocytosis and activity. Moreover, inducible feedback inhibitors including LRIG1, SOCS4, SOCS5 and ERRFI1 constitute alternative regulatory mechanisms for the EGFR signaling.
UniProtKB/Swiss-Prot Function:
Receptor tyrosine kinase binding ligands of the EGF family and activating several signaling cascades to convert extracellular cues into appropriate cellular responses. Known ligands include EGF, TGFA/TGF-alpha, amphiregulin, epigen/EPGN, BTC/betacellulin, epiregulin/EREG and HBEGF/heparin-binding EGF. Ligand binding triggers receptor homo- and/or heterodimerization and autophosphorylation on key cytoplasmic residues. The phosphorylated receptor recruits adapter proteins like GRB2 which in turn activates complex downstream signaling cascades. Activates at least 4 major downstream signaling cascades including the RAS-RAF-MEK-ERK, PI3 kinase-AKT, PLCgamma-PKC and STATs modules. May also activate the NF-kappa-B signaling cascade. Also directly phosphorylates other proteins like RGS16, activating its GTPase activity and probably coupling the EGF receptor signaling to the G protein-coupled receptor signaling. Also phosphorylates MUC1 and increases its interaction with SRC and CTNNB1/beta-catenin. Plays a role in enhancing learning and memory performance (By similarity).
UniProtKB/Swiss-Prot Function:
Isoform 2 may act as an antagonist of EGF action.

Enzyme Numbers (IUBMB) for EGFR Gene

Gene Ontology (GO) - Molecular Function for EGFR Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000166 nucleotide binding IEA --
GO:0001948 glycoprotein binding IEA --
GO:0003682 chromatin binding IDA 20551055
GO:0003690 double-stranded DNA binding NAS 6325948
GO:0004672 protein kinase activity IEA --
genes like me logo Genes that share ontologies with EGFR: view

Phenotypes for EGFR Gene

MGI mutant phenotypes for EGFR:
inferred from 16 alleles
GenomeRNAi human phenotypes for EGFR:
genes like me logo Genes that share phenotypes with EGFR: view

Human Phenotype Ontology for EGFR Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Models for EGFR Gene

MGI Knock Outs for EGFR:

Animal Model Products

Clone Products

  • Addgene plasmids for EGFR

Flow Cytometry Products

No data available for Transcription Factor Targets and HOMER Transcription for EGFR Gene

Localization for EGFR Gene

Subcellular locations from UniProtKB/Swiss-Prot for EGFR Gene

Cell membrane; Single-pass type I membrane protein. Endoplasmic reticulum membrane; Single-pass type I membrane protein. Golgi apparatus membrane; Single-pass type I membrane protein. Nucleus membrane; Single-pass type I membrane protein. Endosome. Endosome membrane. Nucleus. Note=In response to EGF, translocated from the cell membrane to the nucleus via Golgi and ER. Endocytosed upon activation by ligand. Colocalized with GPER1 in the nucleus of estrogen agonist-induced cancer-associated fibroblasts (CAF).
Isoform 2: Secreted.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for EGFR Gene COMPARTMENTS Subcellular localization image for EGFR gene
Compartment Confidence
endoplasmic reticulum 5
endosome 5
extracellular 5
golgi apparatus 5
nucleus 5
plasma membrane 5
cytosol 4
cytoskeleton 3
lysosome 3
vacuole 3
mitochondrion 2
peroxisome 1

Gene Ontology (GO) - Cellular Components for EGFR Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000139 Golgi membrane IEA --
GO:0005576 extracellular region IEA --
GO:0005615 extracellular space NAS 9103388
GO:0005622 intracellular IEA --
GO:0005634 nucleus IDA 12828935
genes like me logo Genes that share ontologies with EGFR: view

Pathways & Interactions for EGFR Gene

SuperPathways for EGFR Gene

SuperPathway Contained pathways
1 RET signaling
2 Apoptotic Pathways in Synovial Fibroblasts
3 Glioma
.51
.43
4 GPCR Pathway
5 GAB1 signalosome
genes like me logo Genes that share pathways with EGFR: view

Pathways by source for EGFR Gene

Interacting Proteins for EGFR Gene

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000275493%0d%0a9606.ENSP00000350941%0d%0a9606.ENSP00000269571%0d%0a9606.ENSP00000265171%0d%0a9606.ENSP00000344818%0d%0a9606.ENSP00000264657%0d%0a
Selected Interacting proteins: P00533-EGFR_HUMAN ENSP00000275493 for EGFR Gene via MINT STRING UniProtKB IID

Symbol External ID(s) Details
GRB2
SHC1
CBL
EGF
ABL2

Gene Ontology (GO) - Biological Process for EGFR Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000165 MAPK cascade TAS --
GO:0000186 activation of MAPKK activity IEA --
GO:0000902 cell morphogenesis IEA --
GO:0001503 ossification NAS 12925580
GO:0001889 liver development IEA --
genes like me logo Genes that share ontologies with EGFR: view

Drugs & Compounds for EGFR Gene

(314) Drugs for EGFR Gene - From: DrugBank, PharmGKB, ClinicalTrials, ApexBio, DGIdb, FDA Approved Drugs, IUPHAR, HMDB, Tocris, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Lapatinib Approved March 2007, Investigational Pharma Inhibition, inhibitor, Biomarker, Target, antagonist EGFR/HER2 inhibitor,potent,selective and reversible, HER2 and EGFR kinase inhibitor, HER2 Inhibitors, Kinase Inhibitors, Epidermal growth factor receptor (EGFR) inhibitors 296
Gefitinib Approved, Investigational Pharma Inhibition, Biomarker, inhibitor, Target, antagonist EGFR Inhibitors, Kinase Inhibitors, Epidermal growth factor receptor (EGFR) inhibitors 351
Erlotinib Approved, Investigational Pharma Inhibition, inhibitor, Biomarker, Target, antagonist EGFR tyrosine kinase inhibitor, EGFR inhibitor, EGFR Inhibitors, Kinase Inhibitors, Epidermal growth factor receptor (EGFR) inhibitors 0
Cetuximab Approved Pharma Antibody, Biomarker, inhibitor, Target, antagonist EGFR Inhibitors, Therapeutic Antibodies, Epidermal growth factor receptor (EGFR) inhibitors 737
Panitumumab Approved, Investigational Pharma inhibitor, Biomarker, antibody, Target, suppressor EGFR inhibitor, EGFR Inhibitors, Therapeutic Antibodies, Epidermal growth factor receptor (EGFR) inhibitors 0

(55) Additional Compounds for EGFR Gene - From: Novoseek, IUPHAR, Tocris, and HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
TGFalpha
ADP
  • Adenosindiphosphorsaeure
  • Adenosine 5'-pyrophosphate
  • Adenosine diphosphate
  • Adenosine pyrophosphate
  • Adenosine-5'-diphosphate
Full agonist, Agonist 58-64-0
AG 490
133550-30-8
AV 412
451492-95-8
CP 724714
383432-38-0

(5) Tocris Compounds for EGFR Gene

Compound Action Cas Number
AG 490 EGFR-kinase inhibitor. Also JAK2, JAK3 inhibitor 133550-30-8
AV 412 Potent inhibitor of EGFR, ErbB2 and Abl receptor tyrosine kinases 451492-95-8
CP 724714 Potent and selective ErbB2 inhibitor 383432-38-0
Iressa Orally active, selective EGFR inhibitor 184475-35-2
PF 6274484 High affinity and potent covalent EGFR kinase inhibitor 1035638-91-5

(81) ApexBio Compounds for EGFR Gene

Compound Action Cas Number
AC480 (BMS-599626) HER1/2 inhibitor,selective and efficacious 714971-09-2
AEE788 (NVP-AEE788) EGFR/HER-2/VEGFR inhibitor 497839-62-0
Afatinib (BIBW2992) Irreversible EGFR/HER2 inhibitor 439081-18-2
AG 494 Potent EGFR-kinase inhibitor 133550-35-3
AG 555 Potent EGFR-kinase inhibitor 133550-34-2
AG 556 EGFR inhibitor 133550-41-1
AG 99 EGFR inhibitor 122520-85-8
AG-1478 EGFR inhibitor,potent and selective 153436-53-4
AG-18 EGFR/PDGFR inhibitor 118409-57-7
AG-490 JAK2/EGFR inhibitor 133550-30-8
AG-490 (Tyrphostin B42) EGFR/JAK2/JAK3 inhibitor 133550-30-8
AP26113 Anaplastic lymphoma kinase (ALK) inhibitor 1197958-12-5
ARRY-380 Tyrosine kinase HER2 and p95-HER2 inhibitor 937265-83-3
AST-1306 EGFR/HER2 inhibitor 897383-62-9
AST-1306 TsOH ErbB2 and EGFR inhibitor 1050500-29-2
AV-412 EGFR/ErbB2 kinase inhibitor 451493-31-5
AV-412 free base EGFR/ErbB2 kinase inhibitor 451492-95-8
AZ5104 EGFR inhibitor 1421373-98-9
AZD3759 EGFR inhibitor,oral active 1626387-80-1
AZD8931 (Sapitinib) ErbB inhibitor 848942-61-0
AZD-9291 Mutated forms EGFR inhibitor 1421373-65-0
AZD-9291 mesylate third generation EGFRm inhibitor, oral and irreversible 1421373-66-1
BIBU 1361 dihydrochloride EGFR inhibitor,potent and selective 793726-84-8
BIBX 1382 EGFR inhibitor,potent and selective 196612-93-8
BMS 599626 dihydrochloride EGFR and ErbB2 inhibitor,potent and selective
BMS-599626 Hydrochloride EGFR/HER2 inhibitor,potent and selective 873837-23-1
BMS-690514 HER/EGFR inhibitor 859853-30-8
Butein Protein kinase inhibitor 487-52-5
Canertinib (CI-1033) HER family tyrosine kinase inhibitor 267243-28-7
Canertinib dihydrochloride Pan-ErbB inhibitor, potent and selective 289499-45-2
CGP 52411 145915-58-8
Chrysophanol 481-74-3
CL-387785 (EKI-785) Irreversible inhibiter of EGFR 194423-06-8
CNX-2006 mutant-EGFR inhibitor, selective and irreversible 1375465-09-0
CO-1686 (AVL-301) EGFR inhibitor 1374640-70-6
Compound 56 REGFR inhibitor 171745-13-4
CP-724714 HER2 inhibitor,potent and selective 537705-08-1
Dacomitinib (PF299804, PF299) HER inhibitor 1110813-31-4
Daphnetin Protein kinases inhibitor for EGFR/PKA/PKC 486-35-1
EGF816 Novel covalent inhibitor of mutant-selective EGFR 1508250-71-2
Epidermal Growth Factor Receptor Peptide (985-996) EGFR Peptide (985-996) 96249-43-3
Erlotinib EGFR tyrosine kinase inhibitor 183321-74-6
Erlotinib Hydrochloride Selective EGFR inhibitor 183319-69-9
Erlotinib mesylate EGFR inhibitor 248594-19-6
FIIN-2 Irreversible inhibitor of FGFR 1633044-56-0
FIIN-3 Irreversible inhibitor of FGFR
Gefitinib (ZD1839) Selective EGFR inhibitor 184475-35-2
Gefitinib hydrochloride Potent EGFR inhibitor 184475-55-6
GW 583340 dihydrochloride 1173023-85-2
HDS 029 881001-19-0
HKI 357 848133-17-5
Icotinib EGFR tyrosine kinase inhibitor 610798-31-7
Icotinib Hydrochloride EGFR inhibitor,potent and specific 1204313-51-8
Ixabepilone Epothilone B analog;microtubule-stabilizing agent 219989-84-1
JNJ 28871063 hydrochloride 944342-90-9
Lapatinib EGFR/HER2 inhibitor,potent,selective and reversible 231277-92-2
Lapatinib Ditosylate EGFR/HER2 inhibitor,potent and selective 388082-78-8
Lavendustin A 125697-92-9
Methyl 2,5-dihydroxycinnamate 63177-57-1
Mutant EGFR inhibitor 1421373-62-7
Mutated EGFR-IN-1 1421372-66-8
Neratinib (HKI-272) HER2/EGFR inhibitor,potent and irreversible 698387-09-6
OSI-420 EGFR inhibitor 183320-51-6
PD 158780 171179-06-9
PD153035 hydrochloride Potent EGFR inhibitor 153436-54-5
PD168393 EGFR inhibitor 194423-15-9
Pelitinib (EKB-569) EGFR inhibitor,potent and irreversible 257933-82-7
SU 5402 VEGFR2/FGFR/PDGFR/EGFR inhibitor 215543-92-3
TAK-285 HER2/EGFR(HER1) inhibitor 871026-44-7
Tyrphostin 9 Selective EGFR/PDGFR inhibitor 10537-47-0
Tyrphostin B44, (-) enantiomer 133550-32-0
Tyrphostin B44, (+) enantiomer 133550-37-5
Vandetanib (ZD6474) VEGFR2/EGFR antagonist 443913-73-3
Vandetanib hydrochloride VEGFR/EGFR inhibitor 524722-52-9
Vandetanib trifluoroacetate VEGFR/EGFR inhibitor 338992-53-3
Varlitinib (ARRY334543) ErbB inhibitor 845272-21-1
WHI-P180 EGFR/Janus Kinase 3 inhibitor 211555-08-7
WHI-P180 hydrochloride inhibitor of Cdk2, EGFR and Janus Kinase 3 153437-55-9
WZ3146 Mutant EGFR inhibitor, potent and irreversible 1214265-56-1
WZ4002 Mutant-selective EGFR inhibitor(L858R,T790M), irreversible and potent 1213269-23-8
WZ8040 EGFR T790M inhibitor,irreversible amd potent 1214265-57-2
genes like me logo Genes that share compounds with EGFR: view

Drug Products

Transcripts for EGFR Gene

Unigene Clusters for EGFR Gene

Epidermal growth factor receptor:
Representative Sequences:

Clone Products

  • Addgene plasmids for EGFR

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for EGFR Gene

No ASD Table

Relevant External Links for EGFR Gene

GeneLoc Exon Structure for
EGFR
ECgene alternative splicing isoforms for
EGFR

Expression for EGFR Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for EGFR Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for EGFR Gene

This gene is overexpressed in Breast (39.8) and Nasal epithelium (18.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for EGFR Gene



NURSA nuclear receptor signaling pathways regulating expression of EGFR Gene:

EGFR

SOURCE GeneReport for Unigene cluster for EGFR Gene:

Hs.488293

mRNA Expression by UniProt/SwissProt for EGFR Gene:

P00533-EGFR_HUMAN
Tissue specificity: Ubiquitously expressed. Isoform 2 is also expressed in ovarian cancers.
genes like me logo Genes that share expression patterns with EGFR: view

Primer Products

No data ava