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Aliases for EGFL8 Gene

Aliases for EGFL8 Gene

  • EGF-Like-Domain, Multiple 8 2 3
  • Vascular Endothelial Statin-2 3 4
  • EGF-Like Protein 8 3 4
  • VE-Statin-2 3 4
  • C6orf8 3 4
  • NG3 3 4
  • Chromosome 6 Open Reading Frame 8 2

External Ids for EGFL8 Gene

Previous HGNC Symbols for EGFL8 Gene

  • C6orf8

Previous GeneCards Identifiers for EGFL8 Gene

  • GC06P031904
  • GC06P032192
  • GC06P032229
  • GC06P032241
  • GC06P031886

Summaries for EGFL8 Gene

GeneCards Summary for EGFL8 Gene

EGFL8 (EGF-Like-Domain, Multiple 8) is a Protein Coding gene. GO annotations related to this gene include calcium ion binding. An important paralog of this gene is EGFL7.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for EGFL8 Gene

Genomics for EGFL8 Gene

Regulatory Elements for EGFL8 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for EGFL8 Gene

Chromosome:
6
Start:
32,164,583 bp from pter
End:
32,168,285 bp from pter
Size:
3,703 bases
Orientation:
Plus strand

Genomic View for EGFL8 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for EGFL8 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

Proteins for EGFL8 Gene

  • Protein details for EGFL8 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q99944-EGFL8_HUMAN
    Recommended name:
    Epidermal growth factor-like protein 8
    Protein Accession:
    Q99944
    Secondary Accessions:
    • B0S884
    • G5E9Q0
    • Q5JP23
    • Q5SSX3
    • Q8IV30

    Protein attributes for EGFL8 Gene

    Size:
    293 amino acids
    Molecular mass:
    32262 Da
    Quaternary structure:
    No Data Available

neXtProt entry for EGFL8 Gene

Proteomics data for EGFL8 Gene at MOPED

Post-translational modifications for EGFL8 Gene

  • Glycosylation at Asn 50
  • Modification sites at PhosphoSitePlus

Other Protein References for EGFL8 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for EGFL8 Gene

Domains & Families for EGFL8 Gene

Suggested Antigen Peptide Sequences for EGFL8 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q99944

UniProtKB/Swiss-Prot:

EGFL8_HUMAN :
  • Contains 2 EGF-like domains.
Domain:
  • Contains 2 EGF-like domains.
  • Contains 1 EMI domain.
genes like me logo Genes that share domains with EGFL8: view

No data available for Gene Families for EGFL8 Gene

Function for EGFL8 Gene

Gene Ontology (GO) - Molecular Function for EGFL8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005509 calcium ion binding IEA --
GO:0005515 protein binding --
genes like me logo Genes that share ontologies with EGFL8: view
genes like me logo Genes that share phenotypes with EGFL8: view

Animal Model Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for EGFL8

In Situ Assay Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for EGFL8 Gene

Localization for EGFL8 Gene

Subcellular locations from UniProtKB/Swiss-Prot for EGFL8 Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for EGFL8 Gene COMPARTMENTS Subcellular localization image for EGFL8 gene
Compartment Confidence
endoplasmic reticulum 1
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for EGFL8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
genes like me logo Genes that share ontologies with EGFL8: view

Pathways & Interactions for EGFL8 Gene

SuperPathways for EGFL8 Gene

No Data Available

Interacting Proteins for EGFL8 Gene

Gene Ontology (GO) - Biological Process for EGFL8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001701 NOT in utero embryonic development ISS --
genes like me logo Genes that share ontologies with EGFL8: view

No data available for Pathways by source and SIGNOR curated interactions for EGFL8 Gene

Drugs & Compounds for EGFL8 Gene

No Compound Related Data Available

Transcripts for EGFL8 Gene

Unigene Clusters for EGFL8 Gene

EGF-like-domain, multiple 8:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for EGFL8

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for EGFL8 Gene

No ASD Table

Relevant External Links for EGFL8 Gene

GeneLoc Exon Structure for
EGFL8
ECgene alternative splicing isoforms for
EGFL8

Expression for EGFL8 Gene

mRNA expression in normal human tissues for EGFL8 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for EGFL8 Gene

This gene is overexpressed in Spinal cord (56.2) and Urinary Bladder (12.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for EGFL8 Gene



SOURCE GeneReport for Unigene cluster for EGFL8 Gene Hs.731888

genes like me logo Genes that share expression patterns with EGFL8: view

Protein tissue co-expression partners for EGFL8 Gene

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for EGFL8 Gene

Orthologs for EGFL8 Gene

This gene was present in the common ancestor of animals.

Orthologs for EGFL8 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia EGFL8 35
  • 86.46 (n)
  • 87.03 (a)
EGFL8 36
  • 86 (a)
OneToOne
dog
(Canis familiaris)
Mammalia EGFL8 35
  • 85.44 (n)
  • 83.96 (a)
EGFL8 36
  • 80 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Egfl8 35
  • 80.14 (n)
  • 81.88 (a)
Egfl8 16
Egfl8 36
  • 79 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia EGFL8 35
  • 99.31 (n)
  • 98.28 (a)
EGFL8 36
  • 98 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Egfl8 35
  • 80.6 (n)
  • 82.84 (a)
oppossum
(Monodelphis domestica)
Mammalia EGFL8 36
  • 74 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia EGFL8 36
  • 66 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia EGFL8 36
  • 44 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia egfl8 35
  • 52.5 (n)
  • 43.5 (a)
fruit fly
(Drosophila melanogaster)
Insecta slow 36
  • 13 (a)
OneToMany
Species with no ortholog for EGFL8:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for EGFL8 Gene

ENSEMBL:
Gene Tree for EGFL8 (if available)
TreeFam:
Gene Tree for EGFL8 (if available)

Paralogs for EGFL8 Gene

Paralogs for EGFL8 Gene

genes like me logo Genes that share paralogs with EGFL8: view

Variants for EGFL8 Gene

Sequence variations from dbSNP and Humsavar for EGFL8 Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type MAF
VAR_048983 -
VAR_019793 -
VAR_019792 -

Structural Variations from Database of Genomic Variants (DGV) for EGFL8 Gene

Variant ID Type Subtype PubMed ID
dgv1929e1 CNV Complex 17122850
nsv830629 CNV Loss 17160897
nsv884706 CNV Loss 21882294
nsv884707 CNV Loss 21882294

Variation tolerance for EGFL8 Gene

Residual Variation Intolerance Score: 52.47% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.43; 77.25% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for EGFL8 Gene

HapMap Linkage Disequilibrium report
EGFL8

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for EGFL8 Gene

Disorders for EGFL8 Gene

Relevant External Links for EGFL8

Genetic Association Database (GAD)
EGFL8
Human Genome Epidemiology (HuGE) Navigator
EGFL8
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
EGFL8
genes like me logo Genes that share disorders with EGFL8: view

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for EGFL8 Gene

Publications for EGFL8 Gene

  1. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 67
  2. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 67
  3. Genome-wide association study identifies novel loci associated with concentrations of four plasma phospholipid fatty acids in the de novo lipogenesis pathway: results from the Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) consortium. (PMID: 23362303) Wu J.H. … Mozaffarian D. (Circ Cardiovasc Genet 2013) 67
  4. Genome-wide association study identifies novel loci associated with circulating phospho- and sphingolipid concentrations. (PMID: 22359512) Demirkan A. … Schmitz G. (PLoS Genet. 2012) 67
  5. Toward an understanding of the protein interaction network of the human liver. (PMID: 21988832) Wang J. … Yang X. (Mol. Syst. Biol. 2011) 67

Products for EGFL8 Gene

Sources for EGFL8 Gene

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