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EGFL7 Gene

protein-coding   GIFtS: 57
GCID: GC09P139553

EGF-Like-Domain, Multiple 7

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
EGF-Like-Domain, Multiple 71 2     VE-STATIN2
Multiple EGF-Like Domains Protein 72 3     ZNEU12
Multiple Epidermal Growth Factor-Like Domains Protein 72 3     Epidermal Growth Factor-Like Protein 72
Vascular Endothelial Statin2 3     MEGF73
EGF-Like Protein 72 3     VE-statin3
NOTCH4-Like Protein2 3     Zneu13
NEU12     

External Ids:    HGNC: 205941   Entrez Gene: 511622   Ensembl: ENSG000001728897   OMIM: 6085825   UniProtKB: Q9UHF13   

Export aliases for EGFL7 gene to outside databases

Previous GC identifers: GC09P132994 GC09P134914 GC09P136829 GC09P138673 GC09P109017


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for EGFL7 Gene:
This gene encodes a secreted endothelial cell protein that contains two epidermal growth factor-like domains. The
encoded protein may play a role in regulating vasculogenesis. This protein may be involved in the growth and
proliferation of tumor cells. Alternate splicing results in multiple transcript variants. (provided by RefSeq,
Feb 2012)

GeneCards Summary for EGFL7 Gene:
EGFL7 (EGF-like-domain, multiple 7) is a protein-coding gene. Diseases associated with EGFL7 include endotheliitis, and eclampsia. GO annotations related to this gene include calcium ion binding. An important paralog of this gene is EGFL8.

UniProtKB/Swiss-Prot: EGFL7_HUMAN, Q9UHF1
Function: Regulates vascular tubulogenesis in vivo. Inhibits platelet-derived growth factor (PDGF)-BB-induced
smooth muscle cell migration and promotes endothelial cells adhesion to the substrate in vitro (By similarity)

Gene Wiki entry for EGFL7 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000009.12  NT_008470.20  NC_018920.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the EGFL7 gene promoter:
         CREB   HSF2   deltaCREB   ARP-1   Pax-2a   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidEGFL7 promoter sequence
   Search Chromatin IP Primers for EGFL7

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat EGFL7


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 9q34.3   Ensembl cytogenetic band:  9q34.3   HGNC cytogenetic band: 9q34.3

EGFL7 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
EGFL7 gene location

GeneLoc information about chromosome 9         GeneLoc Exon Structure

GeneLoc location for GC09P139553:  view genomic region     (about GC identifiers)

Start:
139,553,308 bp from pter      End:
139,567,130 bp from pter
Size:
13,823 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: EGFL7_HUMAN, Q9UHF1 (See protein sequence)
Recommended Name: Epidermal growth factor-like protein 7 precursor  
Size: 273 amino acids; 29618 Da
Secondary accessions: B3KRP0 Q5M7Y5 Q5VUD5 Q96EG0

Explore the universe of human proteins at neXtProt for EGFL7: NX_Q9UHF1

Explore proteomics data for EGFL7 at MOPED

Post-translational modifications: 

  • Glycosylation2 at Thr54, Thr55, Thr190
  • Modification sites at PhosphoSitePlus

  • See EGFL7 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_057299.1  NP_958854.1  

    ENSEMBL proteins: 
     ENSP00000360764   ENSP00000385639   ENSP00000473338   ENSP00000360763   ENSP00000307843  

    EGFL7 Human Recombinant Protein Products:

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    Cloud-Clone Corp. CLIAs for EGFL7


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    Selected InterPro protein domains (see all 7):
     IPR001881 EGF-like_Ca-bd_dom
     IPR000742 EG-like_dom
     IPR009030 Growth_fac_rcpt_N_dom
     IPR013032 EGF-like_CS
     IPR011489 EMI_domain

    Graphical View of Domain Structure for InterPro Entry Q9UHF1

    ProtoNet protein and cluster: Q9UHF1

    4 Blocks protein domains:
    IPB000152 Aspartic acid and asparagine hydroxylation site
    IPB001881 EGF-like calcium-binding
    IPB006210 Type I EGF
    IPB011489 EMI


    UniProtKB/Swiss-Prot: EGFL7_HUMAN, Q9UHF1
    Similarity: Contains 2 EGF-like domains
    Similarity: Contains 1 EMI domain


    EGFL7 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: EGFL7_HUMAN, Q9UHF1
    Function: Regulates vascular tubulogenesis in vivo. Inhibits platelet-derived growth factor (PDGF)-BB-induced
    smooth muscle cell migration and promotes endothelial cells adhesion to the substrate in vitro (By similarity)

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005112Notch binding IEA--
    GO:0005509calcium ion binding IEA--
    GO:0005515protein binding ----
         
    EGFL7 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for EGFL7:
     Decreased Wnt reporter activit 

         6 MGI mutant phenotypes (inferred from 5 alleles(MGI details for Egfl7):
     cardiovascular system  homeostasis/metabolism  mortality/aging  no phenotypic analysis  normal 
     vision/eye 

    EGFL7 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Egfl7tm1.1Cjku for EGFL7

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for EGFL7
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for EGFL7

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for EGFL7
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for EGFL7

    miRNA
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    miRTarBase miRNAs that target EGFL7:
    hsa-mir-361-5p (MIRT044066), hsa-mir-133a-3p (MIRT021710), hsa-mir-126-3p (MIRT006558)

    Block miRNA regulation of human, mouse, rat EGFL7 using miScript Target Protectors
    1 qRT-PCR Assays for microRNA that regulate EGFL7:
    hsa-miR-126
    SwitchGear 3'UTR luciferase reporter plasmidEGFL7 3' UTR sequence
    Inhib. RNA
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    OriGene RNAi products in human, mouse, rat for EGFL7
    Predesigned siRNA for gene silencing in human, mouse, rat EGFL7

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    GenScript: all cDNA clones in your preferred vector (see all 2): EGFL7 (NM_016215)
    Sino Biological Human cDNA Clone for EGFL7
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for EGFL7
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat EGFL7

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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for EGFL7


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    EGFL7_HUMAN, Q9UHF1: Secreted (By similarity)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    extracellular4
    plasma membrane2
    nucleus1

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region ISS--
    GO:0005615extracellular space IEA--

    EGFL7 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for EGFL7
    Interactions:

        Search GeneGlobe Interaction Network for EGFL7

    STRING Interaction Network Preview (showing 5 interactants - click image to see 8)

    Selected Interacting proteins for EGFL7 (Q9UHF12, 3 ENSP000003078434) via UniProtKB, MINT, STRING, and/or I2D (see all 12)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    GFI1BQ5VTD92, 3, ENSP000003447824MINT-2872973 I2D: score=3 STRING: ENSP00000344782
    LOXL2Q9Y4K02, 3, ENSP000003737834MINT-6743620 I2D: score=1 STRING: ENSP00000373783
    LOXL1Q083973, ENSP000002619214I2D: score=1 STRING: ENSP00000261921
    LOXL3P582153, ENSP000002640944I2D: score=1 STRING: ENSP00000264094
    LOXL4Q96JB63, ENSP000002607024I2D: score=1 STRING: ENSP00000260702
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001525angiogenesis IEA--
    GO:0001568blood vessel development ISS--
    GO:0001570vasculogenesis ISS--
    GO:0001938positive regulation of endothelial cell proliferation IMP--
    GO:0030336negative regulation of cell migration IEA--

    EGFL7 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for EGFL7



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for EGFL7 gene (2 alternative transcripts): 
    NM_016215.4  NM_201446.2  

    Unigene Cluster for EGFL7:

    EGF-like-domain, multiple 7
    Hs.91481  [show with all ESTs]
    Unigene Representative Sequence: NR_046367
    7 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000371699(uc004cid.3) ENST00000406555(uc010nbp.3 uc004cie.3)
    ENST00000492862 ENST00000490469 ENST00000492002 ENST00000371698(uc004cih.3)
    ENST00000308874(uc004cif.3)
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat EGFL7 using miScript Target Protectors
    1 qRT-PCR Assays for microRNA that regulate EGFL7:
    hsa-miR-126
    SwitchGear 3'UTR luciferase reporter plasmidEGFL7 3' UTR sequence
    Inhib. RNA
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    OriGene RNAi products in human, mouse, rat for EGFL7
    Predesigned siRNA for gene silencing in human, mouse, rat EGFL7
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    OriGene ORF clones in mouse, rat for EGFL7
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): EGFL7 (NM_016215)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for EGFL7
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat EGFL7
    Primer
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    OriGene qPCR primer pairs and template standards for EGFL7
    OriGene qSTAR qPCR primer pairs in human, mouse for EGFL7
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat EGFL7
      QuantiTect SYBR Green Assays in human, mouse, rat EGFL7
      QuantiFast Probe-based Assays in human, mouse, rat EGFL7

    Additional mRNA sequence: 

    AB125649.1 AF186111.1 AK091964.1 AL512735.1 AY358902.1 AY358903.1 BC012377.1 BC088371.1 
    BC114447.1 BX647866.1 NR_045110.1 NR_045111.1 NR_046367.1 

    18 DOTS entries:

    DT.213306  DT.101984144  DT.442817  DT.100767699  DT.97771027  DT.100757498  DT.100823870  DT.121198540 
    DT.95317895  DT.95084723  DT.100774099  DT.100823876  DT.100823881  DT.100719265  DT.100722850  DT.100764633 
    DT.100823873  DT.95359462 

    Selected AceView cDNA sequences (see all 256):

    CR593160 BM984290 NM_201446 CR611472 BM851585 CR594154 BM974280 AI355851 
    BM988218 BQ962580 BI770233 CA389606 BU160975 AW206481 BX380872 CR616630 
    CD519130 AI634964 AI095704 CR609845 CR615335 BX397391 BI818991 BM677795 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for EGFL7 (see all 14)    About this scheme

    ExUns: 1 ^ 2a · 2b · 2c ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9a · 9b ^ 10 ^ 11 ^ 12a · 12b ^ 13 ^ 14 ^ 15a · 15b ^ 16
    SP1:                                      -     -                 -     -                       -     -                           
    SP2:                          -           -     -                 -     -                       -     -                           
    SP3:                          -           -     -                 -     -                       -     -                           
    SP4:                                                              -     -                       -     -                           
    SP5:                          -           -     -                 -     -                                                         


    ECgene alternative splicing isoforms for EGFL7

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    EGFL7 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GCACAGGCCA
    EGFL7 Expression
    About this image


    EGFL7 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 9) fully expand
     
     Endothelium (Cardiovascular System)    fully expand to see all 2 entries
             Angioblasts Embryonic Blood Islands
     
     Lateral Plate Mesoderm (Gastrulation Derivatives)    fully expand to see all 2 entries
             Angioblasts Embryonic Blood Islands
     
     Adipose (Muscoskeletal System)
             Interscapular Brown Adipose Depot
     
     Head Mesenchyme (Muscoskeletal System)
             Head Mesenchyme
     
     Fibroblasts
             Dermal Fibroblasts Dorsal Dermis
    EGFL7 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    EGFL7 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.91481
        Custom PCR Arrays for EGFL7
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    QuantiFast Probe-based Assays in human, mouse, rat EGFL7
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for EGFL7

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for EGFL7 gene from Selected species (see all 11)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Egfl71 , 5 EGF-like domain 71, 5 78.43(n)1
    78.68(a)1
      2 (18.95 cM)5
    3531561  NM_001164564.11  NP_001158036.11 
     265800145 
    chicken
    (Gallus gallus)
    Aves EGFL71 EGF-like-domain, multiple 7 61.78(n)
    53.28(a)
      417137  XM_415421.4  XP_415421.4 
    lizard
    (Anolis carolinensis)
    Reptilia EGFL76
    EGF-like-domain, multiple 7
    35(a)
    1 ↔ 1
    GL344924.1(21-12348)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia egfl71 EGF-like-domain, multiple 7 60.34(n)
    52.71(a)
      780371  NM_001079441.1  NP_001072909.1 
    zebrafish
    (Danio rerio)
    Actinopterygii egfl71 EGF-like-domain, multiple 7 52.2(n)
    45.74(a)
      678640  NM_001040385.1  NP_001035475.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta slow1 slowdown 45.72(n)
    34.55(a)
      38540  NM_139641.3  NP_647898.3 


    ENSEMBL Gene Tree for EGFL7 (if available)
    TreeFam Gene Tree for EGFL7 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for EGFL7 gene
    EGFL82  
    3 SIMAP similar genes for EGFL7 using alignment to 3 protein entries:     EGFL7_HUMAN (see all proteins):
    F7    PROS1    FBN3

    EGFL7 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for EGFL7 (see all 275)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 9 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs785495821,2
    C,F--139551343(+) CTCCCC/AACACG 1 -- us2k12Minor allele frequency- A:0.09CSA WA 120
    rs1383832861,2
    --139551393(+) CAGGCA/GGGCAG 1 -- us2k10--------
    rs1868861581,2
    C--139551416(+) CAGGGC/TGGCTC 1 -- us2k10--------
    rs1932093971,2
    --139551417(+) AGGGCA/GGCTCC 1 -- us2k10--------
    rs796874851,2
    C,F--139551493(+) GGGAAC/TTTCTC 1 -- us2k13Minor allele frequency- T:0.06WA NA EA 358
    rs1119286241,2
    C,F--139551568(+) CTGGGT/CAAATC 1 -- us2k12Minor allele frequency- C:0.33CSA 3
    rs1438276841,2
    C--139551584(+) CCACCA/GAGTGG 1 -- us2k10--------
    rs747856621,2
    C,F--139551706(+) GGCCTG/ACAGGA 1 -- us2k11Minor allele frequency- A:0.07EA 120
    rs1383916901,2
    C--139551778(+) GGACAC/TGCGAG 1 -- us2k10--------
    rs1429837431,2
    C--139551824(+) CACTCA/GAGGGT 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for EGFL7 (139553308 - 139567130 bp)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for EGFL7 (see all 27):    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2422220CNV Deletion17116639
    nsv509334CNV Insertion20534489
    dgv8401n71CNV Loss21882294
    dgv8407n71CNV Loss21882294
    nsv894386CNV Loss21882294
    nsv894434CNV Loss21882294
    dgv8400n71CNV Loss21882294
    dgv955n27CNV Loss19166990
    dgv8396n71CNV Loss21882294
    dgv8411n71CNV Loss21882294

    Site Specific Mutation Identification with PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 608582    OMIM disorders: --

    11 diseases for EGFL7:    
    About MalaCards
    endotheliitis    eclampsia    pre-eclampsia    hypoxia
    malignant glioma    lung cancer    ataxia    hepatocellular carcinoma
    prostate cancer    prostatitis    breast cancer


    EGFL7 for disorders           About GeneDecksing

    Genetic Association Database (GAD): EGFL7
    Human Genome Epidemiology (HuGE) Navigator: EGFL7 (3 documents)

    Export disorders for EGFL7 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for EGFL7 gene, integrated from 10 sources (see all 39):
    (articles sorted by number of sources associating them with EGFL7)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1, 4 Bailey S.D....Anand S. (Diabetes Care 2010)
    2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    3. DNA sequence and analysis of human chromosome 9. (PubMed id 15164053)1, 2 Humphray S.J.... Dunham I. (Nature 2004)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    5. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PubMed id 12975309)1, 2 Clark H.F.... Gray A.M. (Genome Res. 2003)
    6. Novel role for epidermal growth factor-like domain 7 in metastasis of human hepatocellular carcinoma. (PubMed id 19824075)1, 9 Wu F....Fan C. (Hepatology 2009)
    7. miR-126 inhibits non-small cell lung cancer cells proliferation by targeting EGFL7. (PubMed id 20034472)1, 9 Sun Y....Guo L. (Biochem. Biophys. Res. Commun. 2010)
    8. Epidermal growth factor-like domain 7 (EGFL7) modulates Notch signalling and affects neural stem cell renewal. (PubMed id 19503073)1, 9 Schmidt M.H....Dikic I. (Nat. Cell Biol. 2009)
    9. VE-statin, an endothelial repressor of smooth muscle cell migration. (PubMed id 14592969)1, 9 Soncin F....Stehelin D. (EMBO J. 2003)
    10. [miR-126 modulates the expression of epidermal growth factor-like domain 7 in human umbilical vein endothelial cells in vitro]. (PubMed id 20423846)1, 9 Sun Y.Q....Guo L.L. (Nan Fang Yi Ke Da Xue Xue Bao 2010)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 51162 HGNC: 20594 AceView: EGFL7 Ensembl:ENSG00000172889 euGenes: HUgn51162
    ECgene: EGFL7 H-InvDB: EGFL7

    (According to HUGE)
    About This Section

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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for EGFL7 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for EGFL7 gene:
    Search GeneIP for patents involving EGFL7

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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