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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

EGFL7 Gene

protein-coding   GIFtS: 57
GCID: GC09P139553

EGF-Like-Domain, Multiple 7

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

This gene clusters with an RNA gene
Subcategory (RNA class): lncRNA

Quality score for the ORGUL clustered with this gene is 3

Aliases
EGF-Like-Domain, Multiple 71 2     RP11-251M1.22
Multiple EGF-Like Domains Protein 72 3     VE-STATIN2
Multiple Epidermal Growth Factor-Like Domains Protein 72 3     ZNEU12
Vascular Endothelial Statin2 3     Epidermal Growth Factor-Like Protein 72
EGF-Like Protein 72 3     MEGF73
NOTCH4-Like Protein2 3     VE-statin3
NEU12     Zneu13

External Ids:    HGNC: 205941   Entrez Gene: 511622   Ensembl: ENSG000001728897   OMIM: 6085825   UniProtKB: Q9UHF13   
ORGUL members:         
NONCODE14:n411761      

Export aliases for EGFL7 gene to outside databases

Previous GC identifers: GC09P132994 GC09P134914 GC09P136829 GC09P138673 GC09P109017


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for EGFL7 Gene:
This gene encodes a secreted endothelial cell protein that contains two epidermal growth factor-like domains. The
encoded protein may play a role in regulating vasculogenesis. This protein may be involved in the growth and
proliferation of tumor cells. Alternate splicing results in multiple transcript variants. (provided by RefSeq,
Feb 2012)

GeneCards Summary for EGFL7 Gene: 
EGFL7 (EGF-like-domain, multiple 7) is a protein-coding gene, and is affiliated with the lncRNA class. Diseases associated with EGFL7 include endotheliitis, and pre-eclampsia. GO annotations related to this gene include calcium ion binding. An important paralog of this gene is EGFL8.

UniProtKB/Swiss-Prot: EGFL7_HUMAN, Q9UHF1
Function: Regulates vascular tubulogenesis in vivo. Inhibits platelet-derived growth factor (PDGF)-BB-induced
smooth muscle cell migration and promotes endothelial cells adhesion to the substrate in vitro (By similarity)

Gene Wiki entry for EGFL7 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000009.11  NC_018920.2  NT_024000.16  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the EGFL7 gene promoter:
         CREB   HSF2   deltaCREB   ARP-1   Pax-2a   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidEGFL7 promoter sequence
   Search SABiosciences Chromatin IP Primers for EGFL7

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat EGFL7


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 9q34.3   Ensembl cytogenetic band:  9q34.3   HGNC cytogenetic band: 9q34.3

EGFL7 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
EGFL7 gene location

GeneLoc information about chromosome 9         GeneLoc Exon Structure

GeneLoc location for GC09P139553:  view genomic region     (about GC identifiers)

Start:
139,553,308 bp from pter      End:
139,567,130 bp from pter
Size:
13,823 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: EGFL7_HUMAN, Q9UHF1 (See protein sequence)
Recommended Name: Epidermal growth factor-like protein 7 precursor  
Size: 273 amino acids; 29618 Da
Subcellular location: Secreted (By similarity)
Secondary accessions: B3KRP0 Q5M7Y5 Q5VUD5 Q96EG0

Explore the universe of human proteins at neXtProt for EGFL7: NX_Q9UHF1

Explore proteomics data for EGFL7 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q9UHF1

  • EGFL7 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    EGFL7 Protein Expression
    REFSEQ proteins (2 alternative transcripts): 
    NP_057299.1  NP_958854.1  

    ENSEMBL proteins: 
     ENSP00000360764   ENSP00000385639   ENSP00000473338   ENSP00000360763   ENSP00000307843  

    Human Recombinant Protein Products for EGFL7: 
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    Novus Biologicals EGFL7 Lysates
    Sino Biological Recombinant Protein for EGFL7
    Sino Biological Cell Lysate for EGFL7 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for EGFL7 

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region ISS--
    GO:0005615extracellular space IEA--

    EGFL7 for ontologies           About GeneDecksing



    EGFL7 Antibody Products: 
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    LSBio Antibodies in human, mouse, rat for EGFL7 

    Assay Products for EGFL7: 
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    Cloud-Clone Corp. ELISAs for EGFL7 
    Cloud-Clone Corp. CLIAs for EGFL7


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    5/6 InterPro protein domains (see all 6):
     IPR001881 EGF-like_Ca-bd
     IPR000742 EG-like_dom
     IPR013032 EGF-like_CS
     IPR011489 EMI_domain
     IPR013111 EGF_extracell

    Graphical View of Domain Structure for InterPro Entry Q9UHF1

    ProtoNet protein and cluster: Q9UHF1

    4 Blocks protein domains:
    IPB000152 Aspartic acid and asparagine hydroxylation site
    IPB001881 EGF-like calcium-binding
    IPB006210 Type I EGF
    IPB011489 EMI


    UniProtKB/Swiss-Prot: EGFL7_HUMAN, Q9UHF1
    Similarity: Contains 2 EGF-like domains
    Similarity: Contains 1 EMI domain


    EGFL7 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: EGFL7_HUMAN, Q9UHF1
    Function: Regulates vascular tubulogenesis in vivo. Inhibits platelet-derived growth factor (PDGF)-BB-induced
    smooth muscle cell migration and promotes endothelial cells adhesion to the substrate in vitro (By similarity)

         Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005509calcium ion binding IEA--
    GO:0005515protein binding ----
         
    EGFL7 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for EGFL7:
     Decreased Wnt reporter activit 

         6 MGI mutant phenotypes (inferred from 5 alleles(MGI details for Egfl7):
     cardiovascular system  homeostasis/metabolism  mortality/aging  no phenotypic analysis  normal 
     vision/eye 

    EGFL7 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Egfl7tm1.1Cjku for EGFL7

       inGenious Targeting Laboratory - Custom generated mouse model solutions for EGFL7 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for EGFL7

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for EGFL7 
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    miRNA
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    1 QIAGEN miScript miRNA Assays for microRNA that regulate EGFL7:
    hsa-miR-126
    SwitchGear 3'UTR luciferase reporter plasmidEGFL7 3' UTR sequence
    Inhib. RNA
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    Gene Editing
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    Sirion Biotech Customized adenovirus for overexpression of EGFL7

    Clone
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                         Customized lentivirus expression plasmids for stable overexpression of EGFL7 

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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for EGFL7


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section




    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for EGFL7

    STRING Interaction Network Preview (showing 4 interactants - click image to see more details)

    5/11 Interacting proteins for EGFL7 (Q9UHF12, 3 ENSP000003078434) via UniProtKB, MINT, STRING, and/or I2D (see all 11)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    GFI1BQ5VTD92, 3, ENSP000003447824MINT-2872973 I2D: score=3 STRING: ENSP00000344782
    LOXL2Q9Y4K02, 3, ENSP000003737834MINT-6743620 I2D: score=1 STRING: ENSP00000373783
    LOXL3P582153, ENSP000002640944I2D: score=1 STRING: ENSP00000264094
    DVL2O146413I2D: score=1 
    LOXP283003I2D: score=1 
    About this table

    Gene Ontology (GO): 5/6 biological process terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001525angiogenesis IEA--
    GO:0001568blood vessel development ISS--
    GO:0001570vasculogenesis ISS--
    GO:0001938positive regulation of endothelial cell proliferation IMP--
    GO:0030336negative regulation of cell migration IEA--

    EGFL7 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for EGFL7

    Search CenterWatch for drugs/clinical trials and news about EGFL7

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for EGFL7 gene (2 alternative transcripts): 
    NM_016215.4  NM_201446.2  

    Unigene Cluster for EGFL7:

    EGF-like-domain, multiple 7
    Hs.91481  [show with all ESTs]
    Unigene Representative Sequence: NR_046367
    7 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000371699(uc004cid.3) ENST00000406555(uc010nbp.3 uc004cie.3)
    ENST00000492862 ENST00000490469 ENST00000492002 ENST00000371698(uc004cih.3)
    ENST00000308874(uc004cif.3)
    miRNA
    Products:
         
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat EGFL7
    1 QIAGEN miScript miRNA Assays for microRNA that regulate EGFL7:
    hsa-miR-126
    SwitchGear 3'UTR luciferase reporter plasmidEGFL7 3' UTR sequence
    Inhib. RNA
    Products:
         
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    Sirion Biotech Customized lentivirus for stable overexpression of EGFL7 
                         Customized lentivirus expression plasmids for stable overexpression of EGFL7 
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat EGFL7
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat EGFL7

    Additional mRNA sequence: 

    AB125649.1 AF186111.1 AK091964.1 AL512735.1 AY358902.1 AY358903.1 BC012377.1 BC088371.1 
    BC114447.1 BX647866.1 NR_045110.1 NR_045111.1 NR_046367.1 

    18 DOTS entries:

    DT.213306  DT.101984144  DT.442817  DT.100767699  DT.97771027  DT.100757498  DT.100823870  DT.121198540 
    DT.95317895  DT.95084723  DT.100774099  DT.100823876  DT.100823881  DT.100719265  DT.100722850  DT.100764633 
    DT.100823873  DT.95359462 

    24/256 AceView cDNA sequences (see all 256):

    BX380872 CR593184 BM984290 CR609845 CR616630 BM677795 BM974280 CR593160 
    CR600602 BM919940 BQ962580 BQ278612 AA358091 CR611472 BM988218 BI766061 
    CD519130 CA389606 BP347840 NM_016215 AW206481 CR594154 BM851585 CR615335 

    GeneLoc Exon Structure

    5/14 Alternative Splicing Database (ASD) splice patterns (SP) for EGFL7 (see all 14)    About this scheme

    ExUns: 1 ^ 2a · 2b · 2c ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9a · 9b ^ 10 ^ 11 ^ 12a · 12b ^ 13 ^ 14 ^ 15a · 15b ^ 16
    SP1:                                      -     -                 -     -                       -     -                           
    SP2:                          -           -     -                 -     -                       -     -                           
    SP3:                          -           -     -                 -     -                       -     -                           
    SP4:                                                              -     -                       -     -                           
    SP5:                          -           -     -                 -     -                                                         


    ECgene alternative splicing isoforms for EGFL7

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    EGFL7 expression in normal human tissues (normalized intensities)      EGFL7 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GCACAGGCCA
    EGFL7 Expression
    About this image


    EGFL7 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/15 selected tissues (see all 15) fully expand
     
     Endothelium (Cardiovascular System)    fully expand to see all 17 entries
             Angioblasts Embryonic Capillary Plexus
             Human Cardiac Microvascular Endothelial Cells (HCMEC)   
             blood outgrowth endothelial cell   
     
     Dermis (Integumentary System)    fully expand to see all 3 entries
             Dermal Fibroblasts Dorsal Dermis
             Human Dermal Microvascular Endothelial Cells (HDMEC)   
     
     Umbilical Cord (Extraembryonic Tissues)    fully expand to see all 3 entries
             Human Umbilical Vein Endothelial Cells (HUVEC) (BioTime)   
     
     Heart (Cardiovascular System)    fully expand to see all 2 entries
             Human Cardiac Microvascular Endothelial Cells (HCMEC)   
     
     Lymph (Cardiovascular System)    fully expand to see all 2 entries
             Human Lymphatic Endothelial Cells (HLEC)   

    See EGFL7 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for EGFL7

    SOURCE GeneReport for Unigene cluster: Hs.91481
        SABiosciences Custom PCR Arrays for EGFL7
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    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat EGFL7
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for EGFL7

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for EGFL7 gene from 5/10 species (see all 10)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Egfl71 , 5 EGF-like domain 71, 5 78.43(n)1
    78.68(a)1
      2 (18.95 cM)5
    3531561  NM_198724.21  NP_942017.21 
     265800145 
    chicken
    (Gallus gallus)
    Aves EGFL71 EGF-like-domain, multiple 7 61.89(n)
    53.49(a)
      417137  XM_415421.3  XP_415421.3 
    lizard
    (Anolis carolinensis)
    Reptilia --
    --
    22(a)
    possible ortholog
    GL344924.1(21-12348)
    zebrafish
    (Danio rerio)
    Actinopterygii egfl71 EGF-like-domain, multiple 7 52.2(n)
    45.74(a)
      678640  NM_001040385.1  NP_001035475.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta slow6
    slowdown
    10(a)
    1 → many
    3L(4384442-4403181)


    ENSEMBL Gene Tree for EGFL7 (if available)
    TreeFam Gene Tree for EGFL7 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for EGFL7 gene
    EGFL82  
    4 SIMAP similar genes for EGFL7 using alignment to 3 protein entries:     EGFL7_HUMAN (see all proteins):
    F7    PROS1    FBN3    EGFL8

    EGFL7 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/275 SNPs in EGFL7 are shown (see all 275)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 9 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0489814
    ----see VAR_0489812 P S mis40--------
    VAR_0489824
    ----see VAR_0489822 A G mis40--------
    VAR_0197914
    ----see VAR_0197912 V I mis40--------
    rs785495821,2
    C,F--139551343(+) CTCCCC/AACACG 1 -- us2k12Minor allele frequency- A:0.09CSA WA 120
    rs1383832861,2
    --139551393(+) CAGGCA/GGGCAG 1 -- us2k10--------
    rs1868861581,2
    C--139551416(+) CAGGGC/TGGCTC 1 -- us2k10--------
    rs1932093971,2
    --139551417(+) AGGGCA/GGCTCC 1 -- us2k10--------
    rs796874851,2
    C,F--139551493(+) GGGAAC/TTTCTC 1 -- us2k13Minor allele frequency- T:0.06WA NA EA 358
    rs1119286241,2
    C,F--139551568(+) CTGGGT/CAAATC 1 -- us2k12Minor allele frequency- C:0.33CSA 3
    rs1438276841,2
    C--139551584(+) CCACCA/GAGTGG 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for EGFL7 (139553308 - 139567130 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 10/27 variations for EGFL7 (see all 27):    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2422220CNV Deletion17116639
    nsv509334CNV Insertion20534489
    dgv8401n71CNV Loss21882294
    dgv8407n71CNV Loss21882294
    nsv894386CNV Loss21882294
    nsv894434CNV Loss21882294
    dgv8400n71CNV Loss21882294
    dgv955n27CNV Loss19166990
    dgv8396n71CNV Loss21882294
    dgv8411n71CNV Loss21882294

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 608582    OMIM disorders: --

    9 diseases for EGFL7:    About MalaCards
    endotheliitis    pre-eclampsia    hypoxia    eclampsia
    lung cancer    colon cancer    hepatocellular carcinoma    prostate cancer
    prostatitis


    EGFL7 for disorders           About GeneDecksing

    Genetic Association Database (GAD): EGFL7
    Human Genome Epidemiology (HuGE) Navigator: EGFL7 (3 documents)

    Export disorders for EGFL7 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for EGFL7 gene, integrated from 9 sources (see all 37):
    (articles sorted by number of sources associating them with EGFL7)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Variation at the NFATC2 locus increases the risk of t hiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipr il and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1, 4 Bailey S.D....Anand S. (2010)
    2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    3. DNA sequence and analysis of human chromosome 9. (PubMed id 15164053)1, 2 Humphray S.J.... Dunham I. (2004)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    5. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PubMed id 12975309)1, 2 Clark H.F.... Gray A.M. (2003)
    6. Novel role for epidermal growth factor-like domain 7 in metastasis of human hepatocellular carcinoma. (PubMed id 19824075)1, 9 Wu F....Fan C. (2009)
    7. miR-126 inhibits non-small cell lung cancer cells pro liferation by targeting EGFL7. (PubMed id 20034472)1, 9 Sun Y....Guo L. (2010)
    8. VE-statin, an endothelial repressor of smooth muscle cell migration. (PubMed id 14592969)1, 9 Soncin F....Stehelin D. (2003)
    9. [miR-126 modulates the expression of epidermal growth factor-like domain 7 in human umbilical vein endothelial cells in vitro] (PubMed id 20423846)1, 9 Sun Y.Q....Guo L.L. (2010)
    10. Epidermal growth factor-like domain 7 protects endothelial cells from hyperoxia-induced cell death. (PubMed id 17934064)1, 9 Xu D....Truog W.E. (2008)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 51162 HGNC: 20594 AceView: EGFL7 Ensembl:ENSG00000172889 euGenes: HUgn51162
    ECgene: EGFL7 H-InvDB: EGFL7

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for EGFL7 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for EGFL7 gene:
    Search GeneIP for patents involving EGFL7

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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