Home
GeneCards Guide
Suite
- MalaCards
- GeneALaCart
- GeneDecks
- GeneIP
- GeneLoc
Terms and Conditions
- Terms of Use
- 3rd Party Notice
About Us
User Feedback
Mirror sites

Set Analyses:

Generates a file of GeneCards annotations for your list of genes

Advanced Search

Search By

Section (entire)

for

All GeneCards Within gene subset (to enable gene prioritization):
or upload a file of gene symbols

Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

EGF Gene

protein-coding GIFtS: 73
GCID: GC04P110834

epidermal growth factor

(Previous name: epidermal growth factor (beta-urogastrone) )

Explore 282 diseases affiliated with
EGF via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Epidermal Growth Factor¹ ²
HOMG4² ⁵
URG² ⁵
Epidermal Growth Factor (Beta-Urogastrone)¹
Beta-Urogastrone¹
Pro-Epidermal Growth Factor²

External Ids:	HGNC: 3229¹	Entrez Gene: 1950²	Ensembl: ENSG00000138798⁷	OMIM: 131530⁵	UniProtKB: P01133³

Export aliases for EGF gene to outside databases

Previous GC identifers: GC04P111240 GC04P111104 GC04P111292 GC04P111191 GC04P106566

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for EGF:

This gene encodes a member of the epidermal growth factor superfamily. The encoded protein is synthesized as a large

precursor molecule that is proteolytically cleaved to generate the 53-amino acid epidermal growth factor peptide. This

protein acts a potent mitogenic factor that plays an important role in the growth, proliferation and differentiation

of numerous cell types. This protein acts by binding the high affinity cell surface receptor, epidermal growth factor

receptor. Defects in this gene are the cause of hypomagnesemia type 4. Dysregulation of this gene has been associated

with the growth and progression of certain cancers. Alternate splicing results in multiple transcript

variants.(provided by RefSeq, May 2010)

UniProtKB/Swiss-Prot: EGF_HUMAN, P01133

Function: EGF stimulates the growth of various epidermal and epithelial tissues in vivo and in vitro and of some

fibroblasts in cell culture. Magnesiotropic hormone that stimulates magnesium reabsorption in the renal distal

convoluted tubule via engagement of EGFR and activation of the magnesium channel TRPM6

summary for EGF:

The epidermal growth factor receptor (EGFR) is a receptor tyrosine kinase of the ErbB family. Four members

of the ErbB family have been identified; EGFR (ErbB1, HER1), ErbB2 (HER2), ErbB3 (HER3) and ErbB4 (HER4).

EGFR signaling is initiated by ligand binding to the extracellular ligand binding domain. This initiates

receptor homo-/hetero-dimerization and autophosphorylation by the intracellular kinase domain, resulting in

receptor activation. Following activation, phosphorylation of cytoplasmic substrates occurs and a signaling

cascade is initiated that drives many cellular responses, including changes in gene expression, cytoskeletal

rearrangement, anti-apoptosis and increased cell proliferation.

Gene Wiki entry for EGF (Epidermal growth factor)

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000004.11 NC_018915.1 NT_016354.19

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the EGF gene promoter:
STAT5B STAT1 AP-1 ATF-2 STAT5A CREB deltaCREB c-Jun
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: EGF promoter sequence

Search SABiosciences Chromatin IP Primers for EGF

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat EGF

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 4q25 Ensembl cytogenetic band: 4q25 HGNC cytogenetic band: 4q25

EGF Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
EGF gene location

GeneLoc information about chromosome 4 GeneLoc Exon Structure

GeneLoc location for GC04P110834: view genomic region (about GC identifiers)

Start:	110,834,040 bp from pter	End:	110,934,118 bp from pter
Size:	100,079 bases	Orientation:	plus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: EGF_HUMAN, P01133 (See protein sequence)

Recommended Name: Pro-epidermal growth factor precursor

Size: 1207 amino acids; 133994 Da

Subunit: Interacts with EGFR and promotes EGFR dimerization. Interacts with RHBDF2 (By similarity). Interacts with

RHBDF1; may retain EGF in the endoplasmic reticulum and regulates its degradation through the endoplasmic

reticulum-associated degradation (ERAD)

Subcellular location: Membrane; Single-pass type I membrane protein

Sequence caution: Sequence=AAR84237.1; Type=Erroneous gene model prediction;

6 PDB 3D structures from and Proteopedia for EGF:

1IVO (3D)

1JL9 (3D)

1NQL (3D)

1P9J (3D)

2KV4 (3D)

3NJP (3D)

Secondary accessions: B4DRK7 E9PBF0 Q52LZ6

Alternative splicing: 2 isoforms: P01133-1 P01133-2

Explore the universe of human proteins at neXtProt for EGF: NX_P01133

Post-translational modifications:

O-glycosylated with core 1-like and core 2-like glycans. It is uncertain if Ser-954 or Thr-955 is O-glycosylated. The

modification here shows glycan heterogeneity: HexHexNAc (major) and Hex2HexNAc2 (minor)¹

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_P01133

EGF Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins (3 alternative transcripts):

NP_001171601.1 NP_001171602.1 NP_001954.2

ENSEMBL proteins:

ENSP00000424316 ENSP00000265171 ENSP00000421384

Reactome Protein details: P01133
Human Recombinant Protein Products:

	EMD Millipore Purified and/or Recombinant EGF Protein
	R&D Systems Recombinant & Natural Proteins for EGF
	Enzo Life Sciences proteins for EGF
	OriGene Purified Protein: EGF OriGene Protein Over-expression Lysate: EGF OriGene Custom Protein Services for EGF
	GenScript Purified and Recombinant Proteins for EGF
	Novus Biologicals EGF Proteins Novus Biologicals EGF Lysate
	Sino Biological Recombinant Protein for EGF
	ProSpec Recombinant Protein for EGF
	Uscn Proteins for EGF

Gene Ontology (GO): 5/6 cellular component terms (GO ID links to tree view) (see all 6): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005576	extracellular region	TAS	--
GO:0005615	extracellular space	IEA	--
GO:0005625	soluble fraction	--	--
GO:0005886	plasma membrane	IEA	--
GO:0016021	integral to membrane	IEA	--

EGF for ontologies About GeneDecksing

EGF Antibody Products:

	EMD Millipore Mono- and Polyclonal Antibodies for the study of EGF
	R&D Systems Antibodies for EGF
	Cell Signaling Technology (CST) Antibodies for EGF
	Browse OriGene Antibodies OriGene Custom Antibody Services for EGF
	GenScript Superior Antibodies for EGF
	Novus Biologicals EGF Antibodies
	Search for Antibodies for EGF at Abcam
	Uscn Antibodies for EGF
	ThermoFisher Antibody for EGF

Assay Products for EGF:

	Browse Kits and Assays available from EMD Millipore
	OriGene Custom Immunoassay Development Browse OriGene Fluorogenic Cell Assay Kits
	R&D Systems Flow Cytometry Kits for EGF (see all)
	GenScript Custom Assay Services for EGF
	Cell Signaling Technology (CST) Sandwich ELISA Kits for EGF
	Browse Enzo Life Sciences for kits & assays
	Uscn ELISAs and CLIAs for EGF

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

EGF for domains About GeneDecksing

5/9 InterPro domains/families (see all 9):

IPR000033 LDLR_classB_rpt

IPR016317 Pro-epidermal_GF

IPR001881 EGF-like_Ca-bd

IPR000742 EG-like_dom

IPR011042 6-blade_b-propeller_TolB-like

Graphical View of Domain Structure for InterPro Entry P01133

ProtoNet protein and cluster: P01133

4 Blocks protein families:

IPB000033 Low-density lipoprotein receptor

IPB000152 Aspartic acid and asparagine hydroxylation site

IPB001336 Type I EGF signature

IPB001881 EGF-like calcium-binding

UniProtKB/Swiss-Prot: EGF_HUMAN, P01133

Similarity: Contains 9 EGF-like domains

Similarity: Contains 9 LDL-receptor class B repeats

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

UniProtKB/Swiss-Prot: EGF_HUMAN, P01133

Function: EGF stimulates the growth of various epidermal and epithelial tissues in vivo and in vitro and of some

fibroblasts in cell culture. Magnesiotropic hormone that stimulates magnesium reabsorption in the renal distal

convoluted tubule via engagement of EGFR and activation of the magnesium channel TRPM6

Genatlas biochemistry entry for EGF:

epidermal growth factor,6kDa,synthesized as a large preprotein,EGF membrane glycoprotein also containing nine EGF

repeats and urogastrone

Summary:

During embryonic development, EGF as signaling molecule

affects the following cells: Column Cytotrophoblast Cells in Column Cytotrophoblast Layer, Late Retinal Progenitor Cells in Neuroblastic Layer (see all 4).

EGF as growth factor is involved in stem cell differentiation protocols towards the derivation of the following cells: Hepatocyte-like cells, Nkx2-1 induced endoderm (see all 17).

miRNA Products:		OriGene 3'-UTR Clone: EGF Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat EGF
		6 QIAGEN miScript miRNA Assays for microRNAs that regulate EGF:
		hsa-miR-33a* hsa-miR-3163 hsa-miR-576-5p hsa-miR-145 hsa-miR-590-3p hsa-miR-3182
		SwitchGear 3'UTR luciferase reporter plasmid: EGF 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for EGF (see all 7) OriGene shRNA RFP: EGF OriGene siRNA: EGF
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat EGF

Gene Editing
Products:

DNA2.0 Custom Protein Engineering Service for EGF

Clone Products:		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for EGF (see all 6) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for EGF (see all 3) OriGene custom cloning services � gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: EGF (NM_001945)
		Browse Sino Biological Human cDNA Clones
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for EGF
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat EGF

Cell Line Products:		GenScript Custom overexpressing Cell Line Services for EGF
		Search LifeMap BioReagents cell lines for EGF

In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for EGF

Gene Ontology (GO): 5 molecular function terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005154	epidermal growth factor receptor binding	TAS	15611079
GO:0005509	calcium ion binding	IEA	--
GO:0005515	protein binding	IPI	12620237
GO:0008083	growth factor activity	IDA	15611079
GO:0030297	transmembrane receptor protein tyrosine kinase activator activity	TAS	9712850

EGF for ontologies About GeneDecksing

2 GenomeRNAi human phenotypes for EGF:

Decreased p24 protein expressi

Increased Salmonella enterica

Animal Models:
Mouse knock-out Egf^tm1Dle for EGF
8 MGI mutant phenotypes (inferred from 1 allele) (MGI details for Egf):

digestive/alimentary	endocrine/exocrine gland	growth/size	immune system	integument
normal	reproductive system	vision/eye

EGF for phenotypes About GeneDecksing

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways - 5/75 super-pathways (see all 75) About this table

See pathways by source

Super-pathway

contained gene-specific pathways

Apoptotic Pathways in Synovial Fibroblasts

8/13 pathways (see all 13)
Apoptotic Pathways in Synovial Fibroblasts	1.00	eIF2 Pathway	0.60
p53 Mediated Apoptosis	0.84	Rac1 Pathway	0.58
Mitochondrial Apoptosis	0.73	Nuclear Receptor Activation by Vitamin-A	0.57
DHA Signaling	0.70	Glioma Invasiveness	0.54

Signaling by FGFR

8/12 pathways (see all 12)
Signaling by FGFR	1.00	DAP12 signaling	0.83
Downstream signaling of activated FGFR	0.92	Signaling by EGFR in Cancer	0.83
Signaling by FGFR in disease	0.91	DAP12 interactions	0.76
Signaling by ERBB2	0.89	Signaling by PDGF	0.72

PIP3 activates AKT signaling

8/10 pathways (see all 10)
PI-3K cascade	1.00	PI3K/AKT activation	0.97
PIP3 activates AKT signaling	1.00	GAB1 signalosome	0.96
PI3K/AKT Signaling in Cancer	1.00	Constitutive PI3K/AKT Signaling in Cancer	0.88
PI3K events in ERBB2 signaling	1.00	Signaling by SCF-KIT	0.72

GPCR Pathway

GPCR Pathway	1.00	Estrogen Pathway	0.55
Ras Pathway	0.62	Pancreatic Adenocarcinoma	0.55
Breast Cancer Regulation by Stathmin1	0.58	Paxillin Interactions	0.53
NFAT in Immune Response	0.58	P2Y Receptor Signaling	0.38

TGF-Beta Pathway

TGF-Beta Pathway	1.00	JNK Pathway	0.50
MAPK Family Pathway	0.60	Regulation of eIF4 and p70S6K	0.43
JAK-STAT Pathway	0.57	SOCS Pathway	0.29

Pathway sources
See GeneCards unified pathways
Show all pathways

5/13 EMD Millipore Pathways for EGF (see all 13)

	Transcription Androgen Receptor nuclear signaling
	Signal transduction PTEN pathway
	Cell adhesion PLAU signaling
	Development EGFR signaling pathway
	Translation Non-genomic (rapid) action of Androgen Receptor

5/67 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for EGF (see all 67)

	Molecular Mechanisms of Cancer
	eIF2 Pathway
	Intracellular Calcium Signaling
	JNK Pathway
	ERK5 Signaling

1 Cell Signaling Technology (CST) Pathway for EGF

Tyrosine Kinases / Adaptors

5/14 GeneGo (Thomson Reuters) Pathways for EGF (see all 14)

	Transcription Androgen Receptor nuclear signaling
	Development EGFR signaling pathway
	Development EGFR signaling via small GTPases
	Translation Regulation of EIF2 activity
	Signal transduction PTEN pathway

5/24 BioSystems Pathways for EGF (see all 24)

	Focal Adhesion
	ErbB signaling pathway
	TGF Beta Signaling Pathway
	MAPK signaling pathway
	EGFR1 Signaling Pathway

5/41 Reactome Pathways for EGF (see all 41)

	Signaling by EGFR in Cancer
	Downstream signal transduction
	Signal Transduction
	Signaling by PDGF
	Downstream Signaling Events Of B Cell Receptor (BCR)

1 PharmGKB Pathway for EGF

EGFR Inhibitor Pathway, Pharmacodynamics

5/16 Kegg Pathways (Kegg details for EGF) (see all 16):

	MAPK signaling pathway
	ErbB signaling pathway
	Cytokine-cytokine receptor interaction
	Endocytosis
	Focal adhesion

EGF for pathways About GeneDecksing

Interactions:

SABiosciences Gene Network Central^TM Interacting Genes and Proteins Network for EGF

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

5/154 Interacting proteins for EGF (P01133^{1, 2, 3} ENSP00000265171⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 154)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
EGFR	P00533¹^,²^,³, ENSP00000275493⁴	EBI-640857,EBI-297353 MINT-8146350 MINT-8146425 MINT-25095 MINT-8146487 MINT-8146461 MINT-8146623 MINT-8146300 MINT-8146514 MINT-8146500 MINT-8146380 MINT-8146287 MINT-6169912 I2D: score=6 STRING: ENSP00000275493
S100A4	P26447²^,³, ENSP00000346294⁴	MINT-7256556 I2D: score=1 STRING: ENSP00000346294
ERBB2	P04626³, ENSP00000269571⁴	I2D: score=3 STRING: ENSP00000269571
LMNA	P02545³, ENSP00000357283⁴	I2D: score=2 STRING: ENSP00000357283
MAPKAPK2	P49137³, ENSP00000356070⁴	I2D: score=1 STRING: ENSP00000356070

About this table

Gene Ontology (GO): 5/34 biological process terms (GO ID links to tree view) (see all 34): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0000186	activation of MAPKK activity	IEA	--
GO:0001525	angiogenesis	IDA	15611079
GO:0002576	platelet degranulation	TAS	--
GO:0006260	DNA replication	TAS	9482941
GO:0007165	signal transduction	TAS	--

EGF for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

EGF for compounds About GeneDecksing

Browse Small Molecules at EMD Millipore

Enzo Life Sciences drugs & compounds for EGF

Compounds for EGF available from Tocris Bioscience About this table

Compound	Action	CAS #
Iressa	Orally active, selective EGFR inhibitor	[184475-35-2]
GW 583340 dihydrochloride	Potent dual EGFR/ErbB2 inhibitor; orally active	[388082-81-3]
PD 153035 hydrochloride	EGFR-kinase inhibitor	[153436-54-5]
AG 494	Potent EGFR-kinase inhibitor	[133550-35-3]
AG 1478 hydrochloride	Highly potent EGFR-kinase inhibitor	[153436-53-4]

2 HMDB Compounds for EGF About this table

Compound	Synonyms	CAS #	PubMed Ids
Calcium	Ca (see all 2)	7440-70-2	--
Magnesium	Magnesium (see all 2)	7439-95-4	--

2 DrugBank Compounds for EGF About this table

Compound	Synonyms	CAS #	Type	Actions	PubMed Ids
Alpha-Aminobutyric Acid	--	--	target	--	17139284 17016423 10592235
Sucralfate	--	54182-58-0	target	inducer	1957124 1970337 8578218

10/133 Novoseek chemical compound relationships for EGF gene (see all 133) About this table

Compound	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
tyrosine	89.9	1884	1689318 (6), 14642088 (6), 1801683 (6), 11459228 (5) (see all 99)
ag 1478	89.1	95	10579343 (2), 12580917 (2), 12141529 (2), 10766877 (2) (see all 77)
pd153035	81.2	16	9815602 (2), 11169460 (2), 11792073 (1), 19423651 (1) (see all 14)
gefitinib	78.8	158	15083203 (6), 17311025 (4), 18691415 (4), 19380191 (4) (see all 74)
thymidine	74.8	290	7507605 (6), 1311246 (4), 8687119 (3), 8319182 (3) (see all 99)
cetuximab	74.6	79	18691415 (5), 19380191 (4), 17707800 (3), 12850474 (2) (see all 51)
phosphatidylinositol	73.6	219	7515147 (5), 9886492 (4), 10801833 (4), 16728406 (3) (see all 99)
phosphotyrosine	73.3	57	10634619 (2), 1693615 (1), 7661200 (1), 8081876 (1) (see all 48)
pd 98,059	70.1	84	11277615 (2), 17107667 (2), 10395291 (2), 17283879 (2) (see all 63)
vegf	69.9	648	15690202 (10), 12667326 (7), 15250102 (7), 9626350 (5) (see all 99)

1 PharmGKB related drug/compound annotation for EGF gene

Drug/compound	PharmGKB Annotation
cetuximab	CA

About this table

Search CenterWatch for drugs/clinical trials and news about EGF

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for EGF gene (3 alternative transcripts):

NM_001178130.1 NM_001178131.1 NM_001963.4

Unigene Cluster for EGF:

Epidermal growth factor

Hs.419815 [show with all ESTs]

Unigene Representative Sequence: NM_001963

12 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000509793 ENST00000265171(uc003hzy.4 uc011cfu.2 uc011cfv.2 uc010imk.3)

ENST00000503392 ENST00000502723 ENST00000504633 ENST00000502579 ENST00000541061

ENST00000511228 ENST00000509996 ENST00000544918 ENST00000537316 ENST00000540840

miRNA Products:		OriGene 3'-UTR Clone: EGF Browse OriGene MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat EGF
		6 QIAGEN miScript miRNA Assays for microRNAs that regulate EGF:
		hsa-miR-33a* hsa-miR-3163 hsa-miR-576-5p hsa-miR-145 hsa-miR-590-3p hsa-miR-3182
		SwitchGear 3'UTR luciferase reporter plasmid: EGF 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for EGF (see all 7) OriGene shRNA RFP: EGF OriGene siRNA: EGF
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat EGF

Clone Products:		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for EGF (see all 6) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for EGF (see all 3) OriGene custom cloning services � gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: EGF (NM_001945)
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for EGF
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat EGF

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for EGF Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay in human, mouse, rat EGF
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat EGF
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat EGF

Additional cDNA sequence:

AK299306.1 AK307734.1 AY548762.1 BC093731.1 BC113461.1 BC143357.1 JQ346088.1 X04571.1

8 DOTS entries:

DT.303224 DT.95252684 DT.100018040 DT.100751605 DT.91987341 DT.92032313 DT.95158066 DT.92051525

24/65 AceView cDNA sequences (see all 65):

AY548762 AA954947 AI381567 AW772286 BE501422 AU129376 BG427221 BF104993

BM090637 BG459974 BG460186 BG460092 BX280823 NM_001963 BX485552 BM090870

AI651044 AW300103 BG461255 BQ010822 CD679255 X04571 BG459705 BG460854

GeneLoc Exon Structure

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

EGF expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GAGGCAGGAG

About this image

EGF expression in embryonic tissues and stem cells

Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

4 LifeMap In Vivo Development Anatomical Compartments/Cells

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Early Embryo (Zygote)

Morula

8-Cell Embryo

Early Embryo

Early Embryo (Zygote)

Early Embryo

Alveolar Epithelial Type 2 Cells

Lung

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

Stem Cell Differentiation: 4 LifeMap Cells

Name

Category

Anterior neural specified EBs (Differentiation of h...)

Photoreceptor-like cells (Differentiation of h...)

Definitive endoderm-like cells (A scalable, suspensi...)

Cardiomyocyte-like cells (Spontaneous differen...)

See EGF Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for EGF

SOURCE GeneReport for Unigene cluster: Hs.419815

UniProtKB/Swiss-Prot: EGF_HUMAN, P01133

Tissue specificity: Expressed in kidney, salivary gland, cerebrum and prostate

SABiosciences Expression via Pathway-Focused PCR Arrays including EGF (see all 14):

Osteogenesis in human mouse rat

Oncogenes & Tumor Suppressor Genes in human mouse rat

Neurogenesis in human mouse rat

Nephrotoxicity in human mouse rat

Growth Factors in human mouse rat

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for EGF Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay in human, mouse, rat EGF
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat EGF
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat EGF

In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for EGF

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of animals.

Orthologs for EGF gene from 5/15 species (see all 15) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
chicken (Gallus gallus)	Aves	EGF¹	epidermal growth factor	65.36(n) 55.25(a)		408035 NM_001001292.1 NP_001001292.1
lizard (Anolis carolinensis)	Reptilia	EGF⁶	--	47(a)	1 ↔ 1	5(144304260-144337195)
zebrafish (Danio rerio)	Actinopterygii	Dr.27130²	Danio rerio epidermal growth factor precursor (egf) mRNA, complete cds less	76.93(n)		AY332224.1
honey bee (Apis mellifera)	Insecta	--	--	5(a)	1 ↔ 1	Group9.2(367282-376566)
worm (Caenorhabditis elegans)	Secernentea	F14B4.1⁶	--	18(a)	1 ↔ 1	I(9265944-9270912)

ENSEMBL Gene Tree for EGF (if available)
TreeFam Gene Tree for EGF (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for EGF gene

LRP5² LRP6² LRP2² SORL1² LRP1B² LDLR² LRP5L² LRP4²

VLDLR² NID2² NID1² LRP8² LRP1²

12 SIMAP similar genes for EGF using alignment to 4 protein entries: EGF_HUMAN (see all proteins):

NRG2 EPGN PAMR1 LDLR LRP1B TGFA

AREG LRP5L NPNT SNED1 DKFZp667O055 NRG4

EGF for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 5 variations for EGF
3 CNVs: 92300 63926 6305
2 Indels: 59161 98842
Human Gene Mutation Database (HGMD): EGF

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing EGF

DNA2.0 Custom Variant and Variant Library Synthesis for EGF

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

EGF for disorders           About GeneDecksing

OMIM gene information: 131530
OMIM disorders: 611718
UniProtKB/Swiss-Prot: EGF_HUMAN, P01133

Defects in EGF are the cause of hypomagnesemia type 4 (HOMG4) [MIM:611718]; also known as renal hypomagnesemia

normocalciuric. HOMG4 is a disorder characterized by massive renal hypomagnesemia and normal levels of serum calcium

and calcium excretion. Clinical features include seizures, mild-to mederate psychomotor retardation, and brisk tendon

reflexes

20/282 diseases for EGF (see all 282): About MalaCards

hypomagnesemia acid-labile subunit factor vii deficiency contractural arachnodactyly

perinatal necrotizing enterocolitis microvillus inclusion disease estrogen-receptor negative breast cancer zollinger-ellison syndrome

bronchiolo-alveolar adenocarcinoma malignant peripheral nerve sheath tumor congenital contractural arachnodactyly middle ear cholesteatoma

squamous cell carcinoma atrioventricular septal defect age related macular degeneration xanthogranulomatous pyelonephritis

graft versus host disease non-small cell lung carcinoma sweat gland carcinoma glanzmann's thrombasthenia

20/21 diseases from the University of Copenhagen DISEASES database for EGF (see all 21):

Carcinoma Breast cancer Cholera Malignant glioma

Lung cancer Prostate cancer Gastrointestinal system disease Colorectal cancer

Pancreatic cancer Diphtheria Vascular disease Ovarian cancer

Kidney disease Hepatocellular carcinoma Polycystic kidney disease Urinary bladder cancer

Eye disease Meningioma Endometrial cancer Psoriasis

10/97 Novoseek disease relationships for EGF gene (see all 97) About this table

Disease	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
tumors	73.5	1513	2364377 (7), 2380332 (7), 1709063 (7), 2155590 (6) (see all 99)
breast cancer	69.4	539	17940864 (6), 7749149 (4), 2032259 (4), 10554021 (4) (see all 99)
carcinoma squamous cell	69.1	272	8137238 (3), 2346491 (3), 8638090 (3), 7529189 (3) (see all 99)
cancer	64.3	494	7697894 (5), 2038286 (5), 1473218 (4), 16815674 (3) (see all 99)
carcinoma	60.5	255	11288982 (3), 8321742 (3), 1528299 (3), 15958574 (3) (see all 99)
glioma	58.9	211	10595738 (7), 19634110 (5), 17219981 (4), 12825816 (4) (see all 94)
breast cysts	58.3	33	2249889 (3), 2141515 (3), 12779078 (2), 8368433 (2) (see all 17)
pancreatic cancer	57.6	110	10360220 (7), 16340751 (4), 10050105 (4), 9816541 (4) (see all 57)
glioblastoma	56.7	56	19148517 (3), 17575160 (2), 9440140 (2), 7714611 (2) (see all 33)
prostate cancer	55.9	226	18511414 (4), 9892211 (4), 19356736 (4), 2330326 (3) (see all 99)

Genetic Association Database (GAD): EGF
Human Genome Epidemiology (HuGE) Navigator: EGF (130 documents)
Tumor Gene Database (TGDB): EGF

Export disorders for EGF gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for EGF gene, integrated from 9 sources (see all 5600):
(articles sorted by number of sources associating them with EGF)

Utopia: connect your pdf to the dynamic
world of online information

No association between EGF gene polymorphism and gastric cancer. (PubMed id 16214932)^{1, 4, 9} Goto Y....Hamajima N. (2005)
A single nucleotide polymorphism in the 5' untranslated region of the EGF gene is associated with occurrence and malignant progression of gastric cancer. (PubMed id 15860930)^{1, 4, 9} Hamai Y....Yasui W. (2005)
Epidermal growth factor gene polymorphism is different between schizophrenia and lung cancer patients in Korean population. (PubMed id 15663953)^{1, 4, 9} Lim Y.J....Park Y.H. (2005)
A study of five human cytokine genes in human essential hypertension. (PubMed id 12009575)^{1, 4, 9} Frossard P.M....Lukic M.L. (2002)
EGF activates its receptor by removing interactions that autoinhibit ectodomain dimerization. (PubMed id 12620237)^{1, 2, 9} Ferguson K.M....Lemmon M.A. (2003)
The NMR solution structure of human epidermal growth factor (hEGF) at physiological pH and its interactions with suramin. (PubMed id 21029725)^{1, 2} Huang H.W....Yu C. (2010)
Epidermal growth factor a61g polymorphism is associated with the age of onset of schizophrenia in male patients. (PubMed id 16115648)^{1, 4} Hanninen K....Lehtimaki T. (2007)
No association of EGF polymorphism with schizophrenia in a Japanese population. (PubMed id 15729146)^{1, 4} Watanabe Y....Someya T. (2005)
Epidermal growth factor A61G polymorphism and cardiac autonomic control in adults. (PubMed id 15913871)^{1, 4} Puttonen S....Lehtimaki T. (2005)
Single nucleotide polymorphisms associated with aggressive periodontitis and severe chronic periodontitis in Japanese. (PubMed id 15081423)^{1, 4} Suzuki A....Kamoi K. (2004)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Disorders
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 1950	HGNC: 3229	AceView: EGF	Ensembl:ENSG00000138798	euGenes: HUgn1950
ECgene: EGF	Kegg: 1950	H-InvDB: EGF

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for EGF	Pharmacogenomics, SNPs, Pathways
ATLAS Chromosomes in Cancer entry for EGF	Genetics and Cytogenetics in Oncology and Haematology
NIEHS-SNPs	http://egp.gs.washington.edu/data/egf/
Wikipedia	http://en.wikipedia.org/wiki/Epidermal_growth_factor

Intellectual Property for EGF gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

About This Section

Patent Information for EGF gene:
Search GeneIP for patents involving EGF

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section

	Browse Small Molecules at EMD Millipore
	Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
	EMD Millipore Purified and/or Recombinant EGF Protein
	Browse for Gene Knock-down Tools from EMD Millipore
	EMD Millipore Mono- and Polyclonal Antibodies for the study of EGF
	Browse Kits and Assays available from EMD Millipore

	EMD Millipore Custom Antibody & Bulk Services
	EMD Millipore Preclinical / Clinical Development Services
	EMD Millipore Immunoassay Services
	EMD Millipore Target Screening & Profiling Services

	Antibodies for EGF (EGF)		Browse Cell Culture Products
	ELISAs for EGF (EGF)		Flow Cytometry Kits for EGF (EGF)
	Browse Primer Pairs		Browse Kinase Activity Assays/Reagents
	Browse ELISpot Kits/Development Modules		Browse TFB/Immunoprecipitation Assays
	Browse Apoptosis Detection Kits/Reagents		Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents
	Browse DNA Damage/Repair Kits/Reagents		Multiplex/Array Assay Kits/Reagents for EGF (EGF)
	Browse Cell Selection/Detection Kits/Reagents		Browse Secondary Antibodies/Controls/Staining Reagents
	Browse Phosphatase Activity Assays/Reagents		Recombinant/Natural Proteins for EGF (EGF)

	Browse OriGene Antibodies		OriGene shRNA RFP for EGF
	OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for EGF		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for EGF
	OriGene Protein Over-expression Lysate for EGF		Browse OriGene Fluorogenic Cell Assay Kits
	OriGene siRNA for EGF		OriGene 3'-UTR Clone for EGF
	OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for EGF		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for EGF
	Browse OriGene GFP tagged cDNA clones in CMV expression vector		Browse OriGene MicroRNA Expression Plasmids
	Browse OriGene basic RS shRNAs		Browse OriGene validated miRNA SYBR primer pairs
	OriGene Purified Protein for EGF		OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
	OriGene Custom Antibody Services for EGF		OriGene Custom Protein Services for EGF
	OriGene Custom Immunoassay Development

	QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat EGF
	QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing EGF
	QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat EGF
	QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat EGF
	QIAGEN QuantiFast Probe-based Assays in human, mouse, rat EGF
	QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat EGF

	GenScript Purified and Recombinant Proteins for EGF		GenScript cDNA clones with any tag delivered in your preferred vector for EGF
	GenScript Custom Assay Services for EGF		GenScript Superior Antibodies for EGF
	GenScript Custom overexpressing Cell Line Services for EGF		CloneReady with Over 120,000 Genes
	Gene Synthesis: Any Gene in Any Vector		Vector-based siRNA and miRNA, Ready for Transfection
	Gene Mutant Library, Variants up to 10^11		Plasmid Preparation
	Custom Peptide Services

Antibodies & Assays for EGF

	Regulatory tfbs in EGF promoter
	Search Chromatin IP Primers for EGF
	RT² qPCR Primer Assay in human, mouse, rat EGF
	GNC Network for EGF
	SABiosciences PCR Arrays including human, mouse, rat EGF

Tocris compounds for EGF

	Proteins and Antibodies for EGF
	Browse Sino Biological cDNA Clones
	Antibodies/Proteins Production Services
	Rabbit Monoclonal Antibody Platform
	Bulk Purchasing

	Drugs/Proteins for EGF
	Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

	Novus Tissue Slides
	EGF antibodies
	EGF proteins
	EGF lysates

	Search for Antibodies for EGF at Abcam
	See all of Abcam's Antibodies, Kits and Proteins for EGF
	Custom Antibody / Protein Production Service
	Bulk Purchasing
	Advantages of Rabbit Monoclonal antibodies
	Abcam protocols and scientific support

Recombinant Protein for EGF

EGF Proteins, Antibodies, CLIAs, and ELISAs

Search LifeMap BioReagents cell lines for EGF

	Gene Synthesis
	Protein Engineering
	Variant Library Synthesis
	Codon Optimization
	Protein Production and Purification

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for EGF

	SwitchGear 3'UTR luciferase reporter plasmids for EGF
	SwitchGear Promoter luciferase reporter plasmids for EGF

ThermoFisher Antibody for EGF

Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat EGF

GeneCards Homepage - Last full update: 18 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013

View Random Gene

Category			VWF (GIFTS: 73) von Willebrand factor
GIFtS Group

The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

The GeneCards Human Gene Database

Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

Hot genes Disease genes EGF gene at Home site.

hostname: 356980-web2.xennexinc.com index build: 100 solr: 1.4

Advanced Search

Export list of displayed genes

EGF Gene

epidermal growth factor

Aliases
for EGF gene

Summaries
for EGF gene

Genomic Views
for EGF gene

Proteins
for EGF gene

Protein Domains /
Families
for EGF gene

Function
for EGF gene

Pathways & Interactions
for EGF gene

Drugs & Compounds
for EGF gene

Transcripts
for EGF gene

Expression
for EGF gene

Orthologs
for EGF gene

Paralogs
for EGF gene

Genomic Variants
for EGF gene

Disorders / Diseases
for EGF gene

Publications
for EGF gene

External Searches for EGF gene

Genome Databases showing EGF gene

Other Databases showing EGF gene

Specialized Databases showing EGF gene

Intellectual Property
for EGF gene

Products
for EGF gene

View Random Gene

Brain Tumor Primary
Rieger syndrome
Retinoblastoma
Acneiform Eruptions
THYROID CARCINOMA ANAPLASTIC
aggressiveness
ADENOCARCINOMA LUNG
COLON CARCINOMA
LUNG CARCINOMA
Factor VII Deficiency
Metaplasia
Breast Cancer
Neovascularization
cystitis bacterial
primary tumor
NSCLC
Adenocarcinoma
Neck Cancer
Cancer
NEPHROPATHY OBSTRUCTIVE
premalignant
Colorectal Carcinoma
follicular thyroid cancer
Carcinoma Non-Small Cell Lung
mammary tumor
GASTRIC CARCINOMA
COLON ADENOCARCINOMA
Ovarian Cancer
Cerebral meningioma
Ulcer
Leiomyoma
Colorectal Cancer
ADPKD
HNSCC
Enterocolitis Necrotizing
cervical squamous cell carcinoma
Uterine leiomyoma
Psoriasis
ENDOMETRIAL CARCINOMA
prostate cancer
Tumors
RENAL CYST
Metastasis
Pheochromocytoma
prostatic adenocarcinoma
Necrosis
Glioblastoma
Malignant Glioma
neoplastic transformation
Gastric Cancer
Glioblastoma Multiforme
BREAST CARCINOMA
Chronic ulcer
Brain Tumors
CADASIL
Colon Cancer
bladder cancer
Glioma
Hyperplasia
ARPKD
Squamous Cell Cancer
Carcinoma
Astrocytoma
Polycystic Kidney Diseases
MICROVILLUS INCLUSION DISEASE
salivary gland adenocarcinoma
epithelial tumor
PROSTATE CARCINOMA
Leukemia
Thyroid Cancer
Tympanic Membrane Perforation
Short Bowel Syndrome
Breast Cysts
CERVICAL CARCINOMA
LEPRECHAUNISM
Carcinoma Renal Cell
Pancreatic Cancer
Brain Stem Tumors
Cancer Lung
gastric ulcer
Meningioma
Diphtheria
benign prostatic hyperplasia
OVARIAN CARCINOMA
solid tumor
Carcinoma Squamous Cell
Colorectal Tumors
papillary thyroid cancer
BLADDER CARCINOMA
PANCREATIC CARCINOMA
Cholesteatoma Middle Ear
Gastrointestinal carcinoma
Cholera
Hypercholesterolemia Familial
THYROID CARCINOMA
Endometrial Cancer
Choriocarcinoma

Advanced Search

Export list of displayed genes

EGF Gene

epidermal growth factor

Aliasesfor EGF gene

Summariesfor EGF gene

Genomic Viewsfor EGF gene

Proteinsfor EGF gene

Protein Domains /Familiesfor EGF gene

Functionfor EGF gene

Pathways & Interactionsfor EGF gene

Drugs & Compoundsfor EGF gene

Transcriptsfor EGF gene

Expression for EGF gene

Orthologsfor EGF gene

Paralogsfor EGF gene

Genomic Variantsfor EGF gene

Disorders / Diseasesfor EGF gene

Publicationsfor EGF gene

External Searches for EGF gene

Genome Databases showing EGF gene

Other Databases showing EGF gene

Specialized Databases showing EGF gene

Intellectual Propertyfor EGF gene

Productsfor EGF gene

View Random Gene

Aliases
for EGF gene

Summaries
for EGF gene

Genomic Views
for EGF gene

Proteins
for EGF gene

Protein Domains /
Families
for EGF gene

Function
for EGF gene

Pathways & Interactions
for EGF gene

Drugs & Compounds
for EGF gene

Transcripts
for EGF gene

Expression
for EGF gene

Orthologs
for EGF gene

Paralogs
for EGF gene

Genomic Variants
for EGF gene

Disorders / Diseases
for EGF gene

Publications
for EGF gene

Intellectual Property
for EGF gene

Products
for EGF gene